CN103536355A - Tumor targeted non-destructive low-power laser multi-functional scalpel system - Google Patents
Tumor targeted non-destructive low-power laser multi-functional scalpel system Download PDFInfo
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- CN103536355A CN103536355A CN201310364286.7A CN201310364286A CN103536355A CN 103536355 A CN103536355 A CN 103536355A CN 201310364286 A CN201310364286 A CN 201310364286A CN 103536355 A CN103536355 A CN 103536355A
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Abstract
The invention discloses a tumor targeted non-destructive low-power laser multi-functional scalpel system and relates to the technical field of medical instruments. The tumor targeted non-destructive low-power laser multi-functional scalpel system comprises a photodynamic therapy system and a multi-scalpel system, wherein the photodynamic therapy system is combined with the multi-scalpel system, and the photodynamic therapy system and the multi-scalpel system are connected with a host machine of the multi-scalpel system through active wires. According to the tumor targeted non-destructive low-power laser multi-functional scalpel system, the microcosmic cancer cell killing function of photodynamic therapy is added to current scalpels; due to the adoption of invisible low-power laser, the visual field of an operation is not influenced; by means of the dual-targeting property of the photodynamic therapy, cancer cells are killed selectively, normal tissue of a patient is not injured, a doctor conducting the operation is not influenced, and perfect combination of macroscopic tumor excision and microscopic tumor cell dissection is achieved for the first time.
Description
Technical field:
The present invention relates to technical field of medical instruments, especially a kind of scalpel system, is specifically related to the harmless weak laser Multifunctional bistoury system of a kind of cancer target.
Background technology:
The China Health statistical yearbook demonstration of announcing for 2012, tumor is the primary cause of disease of resident's top ten causes of death reason, crude death rate reaches 172.33/10 ten thousand, far above the heart disease being number two.2004-2005 top ten mortality of malignant tumors is followed successively by pulmonary carcinoma, hepatocarcinoma, gastric cancer, the esophageal carcinoma, colorectal cancer, leukemia, cerebroma, breast carcinoma, cancer of pancreas, osteocarcinoma, and except leukemia, other are all solid tumors, namely the observable tumor of naked eyes.Wherein, total although the resection rate of hepatocarcinoma is being improved but still less than 30% in recent years, more regrettably, even excision, had postoperative recurrent tumor rate is also very high, the relapse rate of 5 years can be up to 70% or higher, and 5 years overall survivals are difficult to surpass 50%; Postoperative 5 years survival rates of advanced gastric carcinoma are between 40%～50% at present; How the postoperative local recurrence of colorectal cancer occurs in 6 months after surgery to 2 years, and colorectal cancer patients postoperative recurrence person is 7 months mean survival time (MST); During after first operation treatment 8～9 months of cerebral glioma, tumor easily recurs.As can be seen here, had postoperative recurrent tumor is the main cause of death.
Therefore, think that at present reasonably take performs the operation is that main comprehensive therapeutic plan is the major measure of prevention of recurrence.But the recurrence of tumor and transfer and cancerous cell are not eliminated clean direct and great relation again.Operation is the primary treatment means of tumor, although postoperative chemicotherapy can be killed the cancerous cell that operation cannot be removed, yet side effect is also very large, a lot of doctors even think that the very large treatment of these side effect has directly caused the antineoplastic immune Disability of body and the cancer stem cell that common cancerous cell has become drug resistance, and accelerate that sb.'s illness took a turn for the worse, so oppose chemicotherapy.
In sum, if there is a kind of operating theater instruments can improve the efficiency of operation, do not damage doctor again, destroy patient's immunity, and the sightless tumor cell of naked eyes is just removed totally when patient performs the operation for the first time, the probability of patient tumors recurrence will reduce greatly, significant.
In conjunction with several frequently seen tumor, analyze: recurrence breast cancer is not all the patient that first visit is advanced carcinoma, this explanation be mainly strict without tumor art operation in art due to, there is residual cancerous cell plantation through cloning propagation, in about half a year, form the large lesser tubercle of diameter 0.3～0.5cm, constantly breed, form cancer ulcer, and infiltrate costicartilage downwards, by subcutaneous lymph chain, reach offside mammary gland, postoperative chemicotherapy can not be avoided cancerous protuberance recurrence, further illustrate in the treatment of breast carcinoma, the radical-ability of operation remains primary.So be not only must strictly grasp without tumor art rule in radical mastectomy in tumor radical cure art, avoid causing local recurrence.In addition, when processing flap, prevent blocked uply, cause cancer embolus residual in subcutaneous lymph pipe network, microvascular cancer embolus is also another major reason of recurrence.In addition the lymph node number removed due to patient's technical factor or the inconsistent ALND art causing of operating difficulty, is less is also the reason of recurrence.Residual cancerous cell is invisible to the naked eye, but the light wave that can be illuminated finds and kills, the penetrance of light wave itself can be treated lymphatic vessel and the microvascular cancer embolus of subcutaneous table superficial part position, this penetration capacity has more advantage than the radical operation of so-called " digging to a depth of three feet " formula, because penetrating of light is not need to carry out ultra-large damage operation just can carry out.And such irradiation time and irradiating machine can only just can provide in operation process.
The position of postoperative recurrence of colorectal cancer can be divided into anastomotic stoma recurrence, intraperitoneal recurrence, nodositas recurrence, mixed type recurrence.Anastomotic stoma recurrence refers to that recurrent tumor is positioned at anastomotic stoma and contiguous intestinal tube around thereof, can be to intracavity or chamber outgrowth, and companion or infiltrate without surrounding tissue; Intraperitoneal recurrence refers to the recurrent tumor on intraperitoneal placenta percreta surface, is multiple or diffusivity; Nodositas recurrence refers to the nodal-like recurrent tumor that intraperitoneal is isolated.As can be seen here, be that the tumor cell all omitted when performing the operation for the first time of which kind of recurrence or the tumor cell that comes off are relevant, that is to say and fail to reach " pulling the grass up by its roots ".Mixed type recurrence refers to that part and liver, lung etc. organize recurrence simultaneously, and the extruding during with operation is relevant, and at this moment the insurmountable problem of scalpel, can only drop to degree minimum by light and handy operation technique.The universality of light-wave irradiation and the penetration power itself having, make it in whole visual area, just to realize the transfer of controlling cancerous cell, comprises that extruding waits the transfer causing.
It is generally acknowledged, liver cancer patient recurs in early days, usually occurs in postoperative 1 year or 2 years, mainly by cancerous cell residual in liver (Ji Dan center origin), is caused.By analyzing, we have listed the clinically hepatocarcinoma excision rear common high-risk Recurrence relevant to optical dynamic therapy characteristic: the edge of excision (incisxal edge) positive, be that tumor at margins of excision is residual, tumor number more (3 of >), or with stellate ganglion; Trunk or Microvascular invasion in liver; Bile duct cancer embolus; Have lymphatic metastasis, these can exhaustively illuminate characteristic and penetration power characteristic by light wave realizes as much as possible and removes clean tumor cell.
Photodynamic therapy claims again photochemotherapy, is a kind of novel therapies for the treatment of tumor, has dual-target, can reach the microscopic scale of killing cancerous cell.Its treatment basis is a kind of cold light chemical reaction, utilize photosensitizer (photosens it izer) optionally by tumor tissues, to be absorbed, then a series of biology-physical chemical process that produce under the exciting light of the respective wavelength matching with it, also referred to as photodynamic reaction, and produce take reactive oxygen species (reactive oxygen species, ROS) thus be the Therapeutic Method of main middle active substance killing tumor cell.Its main principle is to utilize tumor cell and normal structure to have different affinitys to photosensitizer: tumor tissues picked-up and the photosensitizer retaining are more than normal structure.Photosensitizer is through specific wavelength illumination, simultaneously in biological tissue, the participation of oxygen issues third contact of a total solar or lunar eclipse chemical reaction, produce singlet oxygen and (or) free radical, thereby the multiple biomacromolecule in disorganize and cell, finally cause death of neoplastic cells, reach the object for the treatment of.
As can be seen here, it is killing off tumor cells optionally, is particularly useful for killing the tumor cell of the infiltration that cannot find and excise.At different diseased regions, have different meanings, for example tumor cell invasion, to the functional areas of cerebral tissue, if excision by force will cause nervous function infringement, seriously reduces patient's quality of life.A large amount of clinical reports show, PDT can extend malignant brain tumor patient's mean survival time (MST), and improves its quality of life.
Because operative doctor excision carcinoma is the prerequisite that can see based on naked eyes.But in sightless microscopic scale, therefore, operative doctor cannot be realized the carcinoma cell of removing microscopic scale in operation to the sightless carcinoma cell of sending out in Rhizoma Atractylodis Macrocephalae, coming off or having shifted, because it is the category of macroscopic view excision.These carcinoma cells are also the bases of carcinoma recurrence, conventionally just in carcinoma periphery and corresponding lymph vessels tissue, are included in the process that tumor resection touches and drop to the cancerous cell in operating field.In operation process, doctor can in-plant contact these hidden carcinoma cells usually, the macroscopic view excision of carrying out OPK microcosmic treatment and operation in this process combines, the effect of generation is that 1+1 is far longer than 2.This will improve the radical cure effect of operation greatly, reduces the probability of carcinoma recurrence.
Medical worker has obtained the result conforming to other researcher reports in experimentation: mtt assay result display light dynamic action has obvious lethal effect to various cancerous cell, and zooperal result is also consistent with it.The effect that light power is killed tumor had obtained global generally acknowledged already.But, be all that light power is used separately all the time, make its curative effect limited.The deficiency on the other hand existing smooth power technology being applied in tumor operation is that it adopts visible ray treatment, is generally HONGGUANG.Disturb the visual field, be unfavorable for operation technique.In addition, OPK excitation wavelength is shorter, is applicable to show shallow pathological changes, run into deeply the pathological changes method such as need to puncture import optical fiber.
Summary of the invention:
The object of this invention is to provide the harmless weak laser Multifunctional bistoury system of a kind of cancer target, it is integrated on function that OPK microcosmic kills cancerous cell multiple scalpel up till now, and be different from existing optical dynamic therapy technology, select sightless weak laser light wave as excitation source, do not affect surgical field of view, utilize OPK dual-target optionally to kill cancerous cell and do not damage patient's normal structure, operative doctor impacted, having realized the perfect adaptation first of macroscopical tumor resection and microcosmic cleaning tumor cell.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions: it comprises photodynamic therapy system and multiple scalpel system, photodynamic therapy system and multiple scalpel system combine, and photodynamic therapy system is together with multiple scalpel system in combination, and photodynamic therapy system is connected with multiple scalpel system host by active wire with multiple scalpel system.
Multiple scalpel in described multiple scalpel system comprises the various scalpels that only can realize cutting, Blood clotting such as high frequency electric knife, ultrasound knife, argon-gas knife, water cutter, peritoneoscope.
Light power optical fiber in described photodynamic therapy system, the multiple scalpel in multiple scalpel system can link together by adapter, and light power optical fiber also can be built on multiple scalpel utensil.
When the present invention uses, described multiple scalpel system is connected with Multifunctional bistoury system host by active wire, photodynamic therapy system is connected with Multifunctional bistoury system host, and the loop electrode at patient's back place is connected with Multifunctional bistoury system host by loop electrode wire.
Principle of the present invention is: photodynamic therapy system and multiple scalpel system are combined, carry out optical dynamic therapy when performing an operation.Utilize optical dynamic therapy to patient and the radiationless damage of patient, chemical damage and have advantages of targeting, on the basis of not disturbing operation to implement, the carcinoma that scalpel cannot be able to be removed is again organized particularly carcinoma cell clearance.Doctor remains at the tumor resection of performing an operation outwardly, but has in fact comprised the process of light power removing oncocyte, has greatly improved efficiency and the radical rate of operation.In conjunction with operation, by this synchronization scenario, removed virtually the tumor cell that in the past cannot closely touch, comprise the tumor cell coming off in surrounding wetting, that shift in blood vessel lymphoid tissue, art.
The present invention has following beneficial effect:
Integrate in function that OPK microcosmic kills cancerous cell multiple scalpel system up till now, owing to using sightless weak laser, do not affect surgical field of view, utilize OPK dual-target optionally to kill cancerous cell and do not damage patient's normal structure, operative doctor impacted, having realized the perfect adaptation first of macroscopical tumor resection and microcosmic cleaning tumor cell.The Postoperative recurrent rate of tumor will decline more than 50%, because this Multifunctional bistoury system has improved at least 50% the efficiency of operation.
Accompanying drawing explanation:
Fig. 1 be the specific embodiment one photodynamic therapy system and multiple scalpel system by the structural representation of adapter combination,
Fig. 2 is the using state structural representation of the specific embodiment one,
Fig. 3 is that the specific embodiment two photodynamic therapy systems are built in the structural representation in multiple scalpel system.
The specific embodiment:
The specific embodiment one: with reference to Fig. 1, this specific embodiment by the following technical solutions: it comprises light power optical fiber 1, adapter 2, multiple scalpel 3, and light power optical fiber 1 links together by adapter 2 with multiple scalpel 3.
With reference to Fig. 2, in this specific embodiment, light power optical fiber 1, multiple scalpel 3 link together by adapter 2, multiple scalpel 3 is connected with Multifunctional bistoury system host 6 by active wire 4, light power optical fiber 1 is connected with Multifunctional bistoury system host 6, and the loop electrode 7 at patient's back place is connected with Multifunctional bistoury system host 6 by loop electrode wire 5.
The principle of this specific embodiment is: light power optical fiber 1 and multiple scalpel 3 are combined, carry out optical dynamic therapy when performing an operation.Utilize optical dynamic therapy to patient and the radiationless damage of patient, chemical damage and have advantages of targeting, on the basis of not disturbing operation to implement, the carcinoma that multiple scalpel 3 cannot be able to be removed is again organized particularly carcinoma cell clearance.Doctor remains at the tumor resection of performing an operation outwardly, but has in fact comprised the process of light power removing oncocyte, has greatly improved efficiency and the radical rate of operation.In conjunction with operation, by this synchronization scenario, removed virtually the tumor cell that in the past cannot closely touch, comprise the tumor cell coming off in surrounding wetting, that shift in blood vessel lymphoid tissue, art.
This specific embodiment has following beneficial effect:
Integrate in function that OPK microcosmic kills cancerous cell multiple scalpel system up till now, owing to using sightless weak laser, do not affect surgical field of view, utilize OPK dual-target optionally to kill cancerous cell and do not damage patient's normal structure, operative doctor impacted, having realized the perfect adaptation first of macroscopical tumor resection and microcosmic cleaning tumor cell.The Postoperative recurrent rate of tumor will decline more than 50%, because this Multifunctional bistoury system has improved at least 50% the efficiency of tumor operation.
The specific embodiment two: with reference to Fig. 3, this specific embodiment is with the difference of the specific embodiment one: it comprises multiple scalpel blade 8, light power truncation optical fiber lamp hole 9, multiple scalpel operating means 10, light power switch 11 and multiple scalpel switch 12, light power optical fiber built-in is in multiple scalpel operating means 2, multiple scalpel operating means 2 front ends are provided with several smooth power truncation optical fiber lamp holes 9 and multiple scalpel blade 8, are provided with light power switch 11 and multiple scalpel switch 12 on multiple scalpel operating means 2.
Claims (5)
1. cancer target can't harm weak laser Multifunctional bistoury system, it is characterized in that it comprises photodynamic therapy system and multiple scalpel system, photodynamic therapy system and multiple scalpel system combine, and photodynamic therapy system is together with multiple scalpel system in combination, and photodynamic therapy system is connected with multiple scalpel system host by active wire with multiple scalpel system.
2. the harmless weak laser Multifunctional bistoury system of cancer target, is characterized in that the photodynamic therapy system that it comprises is used sightless weak laser, does not affect surgical field of view, operative doctor is not impacted.
3. cancer target can't harm weak laser Multifunctional bistoury system, the principle that it is characterized in that it is: photodynamic therapy system and multiple scalpel system are combined, when performing an operation, carry out optical dynamic therapy, utilize optical dynamic therapy to patient and the radiationless damage of patient, chemical damage and there is targeting, on the basis of not disturbing operation to implement, the carcinoma that scalpel cannot be able to be removed is again organized particularly carcinoma cell clearance, doctor remains at the tumor resection of performing an operation outwardly, but the process that has in fact comprised light power removing oncocyte, efficiency and the radical rate of operation have greatly been improved, in conjunction with hands art, by this synchronization scenario, removed virtually the tumor cell that in the past cannot closely touch.
4. the harmless weak laser Multifunctional bistoury system of cancer target according to claim 1, is characterized in that the multiple scalpel in described multiple scalpel system comprises the various scalpels that only can realize cutting, Blood clotting.
5. cancer target according to claim 1 can't harm weak laser Multifunctional bistoury system, it is characterized in that the light power optical fiber in described photodynamic therapy system, the multiple scalpel in multiple scalpel system can link together by adapter, light power optical fiber also can be built on multiple scalpel utensil.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815964A (en) * | 2014-03-20 | 2014-05-28 | 熊力 | Multi-functional operating knife |
| CN104814789A (en) * | 2015-05-27 | 2015-08-05 | 珠海康弘发展有限公司 | Integrated therapeutic electrode used under endoscope |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070816A (en) * | 1992-07-15 | 1993-04-14 | 浙江大学 | Operation method that laser combines with blade and laser and combined scalpel of blade |
| US5318023A (en) * | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
| US5429635A (en) * | 1994-07-13 | 1995-07-04 | Pioneer Optics Company | Fiberoptic spherical diffuser |
| CN1136815C (en) * | 1993-08-24 | 2004-02-04 | 松下电器产业株式会社 | Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus |
| US6863650B1 (en) * | 1997-07-24 | 2005-03-08 | Karl Storz Gmbh & Co. Kg | Endoscopic instrument for performing endoscopic procedures or examinations |
| CN101176677A (en) * | 2006-11-10 | 2008-05-14 | 上海市卢湾区东南医院 | Operating knife with novel optic fiber |
| CN101579256A (en) * | 2008-05-13 | 2009-11-18 | 上海导向医疗系统有限公司 | Concentric, detachable and replaceable multifunctional targeted tumor scalpel |
| CN101920072A (en) * | 2010-09-08 | 2010-12-22 | 中南大学 | Intracavitary visible photodynamic therapeutic instrument |
-
2013
- 2013-08-21 CN CN201310364286.7A patent/CN103536355A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5318023A (en) * | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
| CN1070816A (en) * | 1992-07-15 | 1993-04-14 | 浙江大学 | Operation method that laser combines with blade and laser and combined scalpel of blade |
| CN1136815C (en) * | 1993-08-24 | 2004-02-04 | 松下电器产业株式会社 | Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus |
| US5429635A (en) * | 1994-07-13 | 1995-07-04 | Pioneer Optics Company | Fiberoptic spherical diffuser |
| US6863650B1 (en) * | 1997-07-24 | 2005-03-08 | Karl Storz Gmbh & Co. Kg | Endoscopic instrument for performing endoscopic procedures or examinations |
| CN101176677A (en) * | 2006-11-10 | 2008-05-14 | 上海市卢湾区东南医院 | Operating knife with novel optic fiber |
| CN101579256A (en) * | 2008-05-13 | 2009-11-18 | 上海导向医疗系统有限公司 | Concentric, detachable and replaceable multifunctional targeted tumor scalpel |
| CN101920072A (en) * | 2010-09-08 | 2010-12-22 | 中南大学 | Intracavitary visible photodynamic therapeutic instrument |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815964A (en) * | 2014-03-20 | 2014-05-28 | 熊力 | Multi-functional operating knife |
| CN104814789A (en) * | 2015-05-27 | 2015-08-05 | 珠海康弘发展有限公司 | Integrated therapeutic electrode used under endoscope |
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Application publication date: 20140129 |