CN103556239B - Batch prepares collection device and the collection method of electrostatic spinning tubular fiber support - Google Patents
Batch prepares collection device and the collection method of electrostatic spinning tubular fiber support Download PDFInfo
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- CN103556239B CN103556239B CN201310597148.3A CN201310597148A CN103556239B CN 103556239 B CN103556239 B CN 103556239B CN 201310597148 A CN201310597148 A CN 201310597148A CN 103556239 B CN103556239 B CN 103556239B
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Abstract
The invention discloses a kind of batch and prepare collection device and the collection method of electrostatic spinning tubular fiber support, this collection device includes chassis and the collection bar being uniformly distributed on chassis, driven by the rotation on chassis and collect bar rotation and revolution, identical spinning fibre can be collected at same environment of same time, reduce the diversity between single tubular fiber support.Many collection bars complete to collect simultaneously, it is achieved the mass production of tubular fiber support.The receiving area of collection device is bigger, it is to avoid cellosilk wafts everywhere, reduces waste, improves production efficiency.Additionally, collect bar be mounted on chassis, collections bar is arranged to sizes and shape simultaneously, according to use needs be replaced, the most also can sheathed collection shell to collect difform tubular fiber support, the scope of application is wider.
Description
Technical field
The invention belongs to micro-nano-scale electricity spinning fibre preparing technical field, be specifically related to a kind of batch system
The collection device of standby electrostatic spinning tubular fiber support and collection method.
Background technology
Electrostatic spinning is a kind of method simply and effectively preparing Nano/micron yardstick fiber aggregate, its system
It is high, fine that the nonwoven tubular bracket of standby micro/nano fiber structure has junction seamless, tube wall porosity
The advantages such as dimension fine degree is high, specific surface area is big, homogeneity is good, bio-medical material, organizational project,
The aspects such as photoelectric material, filtering material, nano composite material and sensor have been obtained for being widely applied.
Comparing tubular bracket prepared by other technology, electrostatic spinning tubular bracket has following several feature:
(1) tube wall is micro nanometer fiber composition, has high gas and liquid permeability.
(2), there is not breach in porous turning slitless connection.
(3) one-shot forming was reprocessed without the later stage.
(4) pipe thickness homogeneity is high.
(5) motility of tubular shape refitting is big.
Such as can produce ganoid artificial blood vessel, surface has the artificial trachea etc. of helicitic texture,
And can in fiber medicine carrying so that electrostatic spinning tubular fiber support has in terms of bio-medical material
Have broad application prospects.
Prepare tubular fiber support and mainly control the collection device of electric spinning device.At present, tubular fiber
The collection device form of support is more single, and the metal bar rotated mainly by an axle center is placed in injection
Front or the lower section of device are collected.As: a kind of circular tube shaped in electrospinning device is collected
Device (Chinese Patent Application No.: 200620132496.9), internal use stainless steel bar is inner core, polytetrafluoro
Ethylene is as cladding material, although meet conduction needs, but collection efficiency is relatively low and can only single receive
Collection, additionally collects diameter unadjustable, and the scope of application is less.A kind of fine electrostatic spins fiber receiving device
(Chinese Patent Application No.: 200720070955.X), employs screw mandrel to control the translation of receiving station left and right
Direction and speed, but still can not overcome can only the shortcoming of single collection.A kind of electrostatic spinning apparatus and
Its commercial Application (China Patent Publication No.: CN1715463A), with the addition of fiber and turns to and lead Kun and fiber
Finished product leads Kun, improves the mechanical property of fiber, but there is no in terms of the batch preparation of product and carry
High.One common point of these collection devices is to collect bar to only have single, and this results in and has the disadvantage that: (1)
Receiving area is little, and acquisition time is long；(2) cellosilk wafts everywhere, has both consumed waste, again inefficiency；
(3) different due to each sample collection time and surrounding, cause single diversity big.Why have
The main cause of disadvantage mentioned above is exactly effectively to collect the shortcomings such as area is little, collection device is single, therefore, needs
Want further Optimal improvements.
In view of problem above, it is necessary to propose the collection device of a kind of tubular fiber support, it is achieved batch is received
The purpose of collection electrostatic spinning, improves collection efficiency, and can collect difform tubular fiber as required
Support, the scope of application is wider.
Summary of the invention
In view of this, the invention provides a kind of batch and prepare the collection dress of electrostatic spinning tubular fiber support
Put and collection method.This collection device receiving area is relatively big, can realize the purpose of batch collection electrostatic spinning,
Improve collection efficiency, and difform collection bar or sheathed collection shell can be changed as required to collect not
The tubular fiber support of similar shape, the scope of application is wider.
A kind of batch proposed according to the purpose of the present invention prepares the collection dress of electrostatic spinning tubular fiber support
Putting, described collection device includes chassis and many collection bars, and described collection bar rotates and is arranged at described chassis
On；Described chassis includes runner and card, and described card is provided with rotation mouth, described many collection bars
Correspondence is installed in described rotation mouth, and can rotation；
Described runner is arranged at described card center position, and described runner is driving gear, described collection
Being fixedly installed driven gear on bar, described driving gear engages each other with described driven gear；
Runner drives card synchronous axial system under the effect of power, it is achieved collects bar and revolves round the sun around runner, with
This simultaneously, driven by rotating wheel driven gear operates, it is achieved collect the spinning motion of bar.
Preferably, described collection bar is be uniformly distributed in described card multiple, the plurality of collection bar
It is positioned on same circumference, and the center that the center of circle is described card.
Preferably, described collection device also includes collecting shell, described collection shell is dismountable be sheathed on described
Collect on bar.
Preferably, the radius of gyration of described collection shell is 1mm-10cm.
A kind of batch prepares the method for electrostatic spinning tubular fiber support, and the batch described in employing prepares electrostatic
The collection device of spinning tubulose fibrous framework, specifically comprises the following steps that
(1), choosing the collection bar of required form, surface is uniformly coated with polymeric coating layer, by multiple receipts
Collection pole pair should be installed in rotation mouth, by the chassis earth of collection device, opens rotation power supply, collects bar
There is revolution and rotation simultaneously；
(2), the electrostatic spinning ejector filling polymer electrostatic spinning solution is ready to, opens electricity
Source, carries out electrostatic spinning；
(3), electrostatic spinning ejector alignment collection device, the velocity of rotation of regulating collecting device and quiet
Electrospun parameter, collects difform tubular fiber support collecting on bar；
(4), collected after, take off collection bar, use the mode soaking the demoulding, will collect on bar
Polymeric coating layer dissolve as synovial fluid, take off electrostatic spinning tubular fiber support, be vacuum dried further.
Preferably, described collection bar is also arranged with collection shell, in order to collect difform tubular fiber
Support, described collection shell scribbles polymeric coating layer uniformly.
Preferably, when electrostatic spinning solution is fat-soluble macromolecule, then polymeric coating layer is that water solublity is high
Molecule, when electrostatic spinning solution is water soluble polymer, then polymeric coating layer is fat-soluble macromolecule.
Preferably, described water soluble polymer is polyvinylpyrrolidone, polyvinyl alcohol, chitosan, bright
One in glue, hyaluronate sodium, starch, Polyethylene Glycol, polymaleic anhydride, polyethylene glycol oxide etc. or
Several mixture.
Preferably, described fat-soluble macromolecule be polylactic acid, polylactic-co-glycolic acid, polylactic acid-
Ethylene glycol copolymer, polylactic acid-polycaprolactone co-polymer, polycaprolactone, poly phosphate, Merlon
With the mixture of one or more in condensing model etc..
Preferably, described water soluble polymer is polyvinylpyrrolidone analog copolymer, described fat-soluble height
Molecule is polylactic acid-based copolymer.
Compared with prior art, batch disclosed by the invention prepares the collection of electrostatic spinning tubular fiber support
The advantage of device and collection method is: this collection device includes chassis and the collection being uniformly distributed on chassis
Bar, is driven by the rotation on chassis and collects bar rotation and revolution, can collect at same environment of same time
Identical spinning fibre, reduces the diversity between single tubular fiber support.Many collection bars complete simultaneously
Collect, it is achieved the mass production of tubular fiber support.The receiving area of collection device is bigger, it is to avoid fine
Dimension silk wafts everywhere, reduces waste, improves production efficiency.Additionally, collect bar to be mounted at chassis
On, collection bar is arranged to sizes and shape, according to using needs to be replaced, additionally also simultaneously
Can sheathed collection shell to collect difform tubular fiber support, the scope of application is wider.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to reality
Execute the required accompanying drawing used in example or description of the prior art to be briefly described, it should be apparent that below,
Accompanying drawing in description is only some embodiments of the present invention, for those of ordinary skill in the art,
On the premise of not paying creative work, it is also possible to obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the collection device that a kind of batch disclosed by the invention prepares electrostatic spinning tubular fiber support
Structural representation Fig. 1.
Fig. 2 is the collection device that a kind of batch disclosed by the invention prepares electrostatic spinning tubular fiber support
Structural representation Fig. 2.
Fig. 3 is the sectional view collecting bar.
Fig. 4 is the collection bar for collecting smooth electrostatic spinning tubular fiber support.
Fig. 5 is the collection bar for collecting cross connection tubulose fibrous framework.
Fig. 6 is the collection bar of the tubular fiber support for collecting thread surface shape.
Fig. 7 is the collection bar of the fibrous framework for collecting fluffy stereochemical structure.
Numeral in figure or the title of the corresponding component representated by letter:
1, runner 2, card 3, collection bar 4, driven gear 5, collection shell 6, rotation mouth
Detailed description of the invention
Electrostatic spinning collection device of the prior art is only limited to single collection bar and collects, and there is receiving area
Little, acquisition time is long；The problems such as cellosilk wafts everywhere, had both consumed waste, again inefficiency；And by
Different in each sample collection time and surrounding, cause single sample diversity big.
The present invention is directed to deficiency of the prior art, it is provided that a kind of batch prepares electrostatic spinning tubular fiber
The collection device of support and collection method.This collection device receiving area is relatively big, can realize batch collection quiet
The purpose of Electrospun, improve collection efficiency, and can change as required difformity size collection bar or
Sheathed collection shell is to collect difform tubular fiber support, and the scope of application is wider.
By detailed description of the invention, technical scheme will be clearly and completely described below.
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.
Based on the embodiment in the present invention, those of ordinary skill in the art are not under making creative work premise
The every other embodiment obtained, broadly falls into the scope of protection of the invention.
As Figure 1-3, a kind of batch prepares the collection device of electrostatic spinning tubular fiber support, this collection
Device includes chassis and many collection bars 3, collects bar 3 rotation and is arranged on chassis；Chassis includes runner 1
With card 2, card 2 being provided with rotation mouth 6, many collection bar 3 correspondences are installed in rotation mouth 6,
And can rotation；Identical spinning can be collected at same environment of same time by arranging many collection bars
Fiber, it is achieved thereby that the mass production of tubular fiber support, improves production efficiency.
Wherein, chassis realizes operating by driven by rotating wheel card, and rotating speed can regulate the most voluntarily, turns
Speed is 0～1000rpm.The diameter range of card is 5cm～50cm.The quantity rotating mouth is 0-100,
Collect bar to need to be installed on one by one in rotation mouth according to use.Collect bar and can realize rotation in rotating mouth,
Its rotational velocity is 0-3000rpm.The diameter collecting bar in rotation mouth is generally 1mm-10cm, a length of
1mm-50cm.Depending on concrete size is according to using needs.
The size wherein rotating mouth can be fixed, and the two ends of various sizes of collection bar all can be set to and rotate
Mouth size matches, and to realize the standardization on chassis, can change different collection bars during use as required,
The scope of application is wider.
Runner 1 is arranged at card 2 center position, and runner 1 is driving gear, collects on bar 3 fixing
Being provided with driven gear 4, driving gear engages each other with driven gear 4.Runner 1 is under the effect of power
Drive card 2 synchronous axial system, it is achieved collecting bar 3 and revolve round the sun around runner 1, meanwhile, runner 1 carries
Dynamic driven gear 4 operates, it is achieved collect the spinning motion of bar 3.
Collecting bar 3 multiple for be uniformly distributed in card, multiple collection bars are positioned on same circumference, and
The center of circle is the center of described card.
This collection device achieves revolution, rotation by using the design of planetary gear system.Planetary gear
Except can as fixed axis gear round oneself rotary shaft rotate in addition to, their rotary shaft also as
Planet carrier rotates around the axis of other gear.Rotation around oneself axis is referred to as rotation, around other gear shaft
The rotation of line is referred to as revolution.In collection device, driven gear is planetary gear, and driving gear is sun gear, dish
Face is then planet carrier, and collecting bar can be with certain speed rotation under machine drives, simultaneously can be at driving tooth
Wheel revolves round the sun along driving gear under driving；Collection bar is off-loadable, change different-diameter.
By the application of planetary gear system, planetary gear can enter around sun gear again while rotation
Row revolution, many collection bars in same card work simultaneously, can collect phase by same environment of same time
Same spinning fibre, it is achieved thereby that the mass production of tubular fiber support.
Collect bar to need to be arranged to multiple shape according to use, can come by changing the diameter collecting bar
Prepare the electrostatic spinning tubular fiber support of different-diameter, it is also possible to receive by changing the pattern collecting bar
Collect the fibrous framework of various pattern.As shown in figs. 4-7, the smooth Static Spinning fiber tube of different-diameter can be collected
Shape fiber, shape the most criss-cross connection tubulose fibrous framework, the tubular fiber support of thread surface shape, with
And fluffy stereochemical structure fibrous framework etc..The collection bar planform of shape such as example is the most a variety of, can
Collect the electrospun fibrous scaffolds of various pattern preparing different bars of collecting according to different demands, and
And manufacturing process is simple, with low cost.
Collection device also includes collecting shell 5, collects dismountable being sheathed on of shell 5 and collects on bar.By arranging
Collect shell and can collect the fibrous framework of various special shape.Collect shape can be smooth, screw thread, concavo-convex,
The various special shapes such as groove, right angle, spherical, oval, triangle, collect the shell radius of gyration general
For 1mm～10cm.Wherein, collecting shell is metallic conduction substrate.
A kind of batch prepares the method for electrostatic spinning tubular fiber support, uses batch to prepare Static Spinning fiber tube
The collection device of shape fibrous framework, specifically comprises the following steps that
S1, choosing the collection bar 3 of required form, surface is uniformly coated with polymeric coating layer, by multiple collection bars
Corresponding is installed in rotation mouth 6, by the chassis earth of collection device, opens rotation power supply, collects bar 3
There is revolution and rotation simultaneously.Polymeric coating layer is water soluble polymer or fat-soluble macromolecule, mainly
Being changed for electrostatic spinning solution, if electrostatic spinning solution is fat-soluble macromolecule, then macromolecule is coated with
Layer is water soluble polymer, otherwise or.
Water soluble polymer is polyvinylpyrrolidone, polyvinyl alcohol, chitosan, gelatin, hyaluronic acid
The mixture of one or more in sodium, starch, Polyethylene Glycol, polymaleic anhydride, polyethylene glycol oxide etc..
Wherein, water soluble polymer is preferably polyvinylpyrrolidone analog copolymer.
Fat-soluble macromolecule be polylactic acid, polylactic-co-glycolic acid, PLA-PEG copolymer,
In polylactic acid-polycaprolactone co-polymer, polycaprolactone, poly phosphate, Merlon and condensing model etc. one
Kind or several mixture,
Wherein, fat-soluble macromolecule is preferably polylactic acid-based copolymer.
S2, the electrostatic spinning ejector filling polymer electrostatic spinning solution is ready to, turns on the power,
Carry out electrostatic spinning.
S3, electrostatic spinning ejector alignment collection device, the velocity of rotation of regulating collecting device and Static Spinning
Silk parameter, collects difform tubular fiber support collecting on bar 3.
S4, collected after, take off collection bar 3, use the mode soaking the demoulding, will collect on bar 3
Polymeric coating layer dissolves as synovial fluid, takes off electrostatic spinning tubular fiber support, is vacuum dried further.
Electrostatic spinning solution is any material carrying out electrostatic spinning.Soak the mode of the demoulding for collecting
Bar is immersed in the solvent of solubilized polymeric coating layer, is dissolved by polymeric coating layer, thus forms synovial fluid,
Fibrous framework is disengaged with collecting bar.The fibrous framework of different-shape can be collected, as collected by which
The smooth electrostatic spinning tubular fiber support of different-diameter, can be used for the materials such as manufacture of intraocular blood vessel.Permissible
Collect shape the most criss-cross connection tubulose fibrous framework.The tubular fiber support of thread surface shape can be collected,
Can be used for the preparation of the materials such as artificial esophagus.May be used for collecting fluffy stereochemical structure fibrous framework.
Additionally, also sheathed different size and the collection shell of shape on bar can be being collected, in order to collect not similar shape
The tubular fiber support of shape, collects and scribbles polymeric coating layer uniformly on shell.
Use collect the tubular fiber support that shell collects can be lead directly to, bending, manifold, spherical, groove,
The various special tubular form such as screw thread, concavo-convex, right angle, spherical, oval, triangle.Pipe diameter size
For 1mm～10cm, tube length is 1mm～50cm, and pipe thickness is 10 μm～10mm, and porosity is
20.0%～95.0%, individual fiber diameter is 50nm～10 μm, the material of tubular bracket can be various can
The materials such as organic and inorganic, the metal of electrostatic spinning.
Wherein, the electrospinning device in the method is conventional and unconventional any equipment, electrostatic spinning
Solution is any material carrying out Static Spinning.
By the improvement of above-mentioned technology, also have and avoid that acquisition time is long, collection efficiency low, reduce
The advantages such as the diversity of sample room: it is possible, firstly, to many tubular fiber supports of disposable collecting, more single
It is big that the device collected receives the gross area, and the scope receiving spray webbing is big, thus improves fiber collection efficiency,
Improve general electrostatic spinning apparatus collection efficiency this deficiency low；Secondly as each sample collection
Time and surrounding are identical, it is possible to well reduce the diversity of sample room；Finally, single receipts are used
The time collecting one during acquisition means uses this collection device can collect many, greatly reduces acquisition time,
Avoid acquisition time long, improve production efficiency.
The each parameter of this electrostatic spinning apparatus is as follows: high-voltage power voltage scope 0-20KV；Puopulsion equipment speed
Scope 0-10ml/h, motor speed 0-3000rpm.
The mode of production of fibrous framework is as follows:
Embodiment 1
Weigh 1gPCL and be dissolved in 2g CH2Cl2Magnetic stirring apparatus stirs to polymer and be completely dissolved, then
Add 1g dehydrated alcohol, continue stirring to fully dissolving.Choosing No. 7 syringe needles, internal diameter is 0.5mm, logical
Crossing micro-injection pump, coutroi velocity is 1ml/h, and voltage is controlled to be 2kV by electrostatic generator.Positive source
Connecing at the syringe needle of syringe, negative pole is connected with the metal of collecting terminal.Base diameter is 5cm, chooses diameter
For 3, the pole of 1cm length 5cm, in PVP solution, steeped (for gathering the rear demoulding) in advance,
Inserted base rotates in mouth.Regulation revolution rotational speed regulation syringe needle is 10cm to the distance of collecting terminal support.Temperature
Spend 25 DEG C, relative humidity 50%.Start after switching on power to collect fiber.
Embodiment 2
Weigh 1gPCL and be dissolved in 2g CH2Cl2Magnetic stirring apparatus stirs to polymer and be completely dissolved, then
Add 1g dehydrated alcohol, continue stirring to fully dissolving.5,10 and are weighed respectively with analytical precision balances
20mg paclitaxel powder, loads in little plastic containers, add the HFIP dissolving of 0.5ml with pipet after,
The drug solution prepared is dropped in polymer solution, is sufficiently mixed uniformly.By micro-injection pump,
Coutroi velocity is 2ml/h, and voltage is controlled to be 4kV by electrostatic generator.Positive source connects the syringe needle of syringe
Place, negative pole is connected with the metal of collecting terminal.Base diameter is 10cm, chooses a diameter of 4mm length 10cm
6, pole, steeped in PVP solution in advance, inserted base rotates in mouth.Regulation revolution rotating speed is adjusted
Markingoff pin head is 10cm to the distance of collecting terminal support.Temperature 25 DEG C, relative humidity 50%.Switch on power
After start to collect fiber.
Embodiment 3
Weigh 1gPCL and be dissolved in 2.5g CH2Cl2Magnetic stirring apparatus stirs to polymer and be completely dissolved, then
Add 1g dehydrated alcohol, continue stirring to fully dissolving.By micro-injection pump, coutroi velocity is 3ml/h,
Voltage is controlled to be 8kV by electrostatic generator.Positive source connects at the syringe needle of syringe, negative pole and collecting terminal
Metal be connected.Base diameter is 50cm, chooses 20, the pole of a diameter of 4mm length 10cm,
Steeping in PVP solution in advance, inserted base rotates in mouth.Regulation revolution rotational speed regulation syringe needle is to collecting
The distance of end support is 15cm.Temperature 15 DEG C, relative humidity is 35%.Start after switching on power to collect
Fiber.
Embodiment 4
1g Merlon (Mw=90KDa) is dissolved in 6g dichloromethane and 1gN, N-dimethyl methyl
In the mixed solvent of amide, magnetic agitation, the electrostatic solution of the Merlon fully dissolved.Logical
Crossing micro-injection pump, coutroi velocity is 3.6ml/h, and voltage is controlled to be 10kV by electrostatic generator.Power supply
Positive pole connects at the syringe needle of syringe, and negative pole is connected with the metal of collecting terminal.Base diameter is 30cm, chooses
12, the pole of a diameter of 1cm length 10cm, steeped in advance in releasing agent, and inserted base rotates mouth
In.Regulation syringe needle is 15cm to the distance of collecting terminal support.Start after switching on power to collect fiber.
Embodiment 5
0.8g polylactic-co-glycolic acid (PLGA, Mw=90KDa) is dissolved in 3g dichloromethane
And 1gN, in the mixed solvent of dinethylformamide, magnetic agitation, the PLGA fully dissolved
Electrostatic solution.By micro-injection pump, coutroi velocity is 4ml/h, and voltage by electrostatic generator control is
12kV.Positive source connects at the syringe needle of syringe, and negative pole is connected with the metal of collecting terminal.Base diameter is
30cm, chooses 20, the pole of a diameter of 8mm length 20cm, steeped in advance in releasing agent, inserts
Enter base to rotate in mouth.Regulation syringe needle is 15cm to the distance of collecting terminal support.Start after switching on power to receive
Collection fiber.
Embodiment 6
Polyvinyl alcohol 0.87g is added in 10ml deionized water, magnetic agitation, add appropriate sodium chloride and
Citric acid, makes the transparent without precipitation PVA spinning liquid of concentration 8%.By micro-injection pump, control stream
Speed is 5ml/h, and voltage is controlled to be 14kV by electrostatic generator.Positive source connects at the syringe needle of syringe,
Negative pole is connected with the metal of collecting terminal.Base diameter is 40cm, chooses a diameter of 2cm length 20cm
20, pole, steeped in advance in releasing agent, and inserted base rotates in mouth.Regulation syringe needle props up to collecting terminal
The distance of frame is 20cm.Start after switching on power to collect fiber.
Embodiment 7
Poly(ethylene oxide) 0.526g is added in 10ml deionized water, magnetic agitation, adds appropriate sodium chloride,
Make the transparent without precipitation PEO spinning liquid of concentration 5%.By micro-injection pump, coutroi velocity is 6ml/h,
Voltage is controlled to be 14kV by electrostatic generator.Positive source connects at the syringe needle of syringe, negative pole and collecting terminal
Metal be connected.Base diameter is 50cm, chooses 80, the pole of a diameter of 2mm length 10cm,
Steeping in releasing agent in advance, inserted base rotates in mouth.Regulation syringe needle to the distance of collecting terminal support is
15cm.Start after switching on power to collect fiber.
Embodiment 8
Taking 0.18gP (LLA-CL) to be dissolved in 3ml acetone, magnetic agitation is to being completely dissolved, and obtaining concentration is
The blend spinning solution 3ml of 6%.By micro-injection pump, coutroi velocity is 8ml/h, and voltage is sent out by electrostatic
Raw device controls as 15kV.Positive source connects at the syringe needle of syringe, and negative pole is connected with the metal of collecting terminal.
Base diameter is 50cm, chooses 4, the pole of a diameter of 10cm length 50cm, in advance at releasing agent
In steeped, inserted base rotates in mouth.Regulation syringe needle is 20cm to the distance of collecting terminal support.Connect electricity
Start behind source to collect fiber.
Embodiment 9
Weigh 1gPCL and be dissolved in 2.5g CH2Cl2Magnetic stirring apparatus stirs to polymer and be completely dissolved, then
Add 1g dehydrated alcohol, continue stirring to fully dissolving.By micro-injection pump, coutroi velocity is 10ml/h,
Voltage is controlled to be 20kV by electrostatic generator.Positive source connects at the syringe needle of syringe, negative pole and collecting terminal
Metal be connected.Base diameter is 30cm, chooses 12, the pole of a diameter of 4mm length 10cm,
And such as the collection shell of Fig. 7 is added above, and to collect shell and steeped in releasing agent in advance, inserted base rotates
In mouthful.Regulation revolution rotational speed regulation syringe needle is 15cm to the distance of collecting terminal support.Temperature 15 DEG C, phase
It is 35% to humidity.Start after switching on power to collect fiber.Fluffy stereochemical structure fiber can be obtained prop up
Frame.
Embodiment 10
0.275g polylactic acid (PDLLA, Mw=45KDa) is dissolved in 8mlN, N-mono-dimethyl methyl
In amide (DMF) and 2ml oxolane (THF), under room temperature, magnetic agitation forms stable homogeneous
Solution.By micro-injection pump, coutroi velocity is 0.2ml/h, and voltage is controlled to be 5kV by electrostatic generator.
Positive source connects at the syringe needle of syringe, and negative pole is connected with the metal of collecting terminal.Base diameter is 30cm,
Choosing such as Fig. 6 thread surface shape, 6, the pole of a diameter of 4mm length 20cm, in advance at releasing agent
In steeped, inserted base rotates in mouth.Regulation syringe needle is 15cm to the distance of collecting terminal support.Connect electricity
Start behind source to collect fiber.The tubular fiber support of thread surface shape can be obtained.
The invention discloses a kind of batch and prepare collection device and the collection side of electrostatic spinning tubular fiber support
Method, this collection device includes chassis and the collection bar being uniformly distributed on chassis, by the rotational band on chassis
Dynamic collection bar rotation and revolution, can collect identical spinning fibre at same environment of same time, reduce
Diversity between single tubular fiber support.Many collection bars complete to collect simultaneously, it is achieved tubular fiber props up
The mass production of frame.The receiving area of collection device is bigger, it is to avoid cellosilk wafts everywhere, reduces waste,
Improve production efficiency.It is mounted on chassis additionally, collect bar, collection bar is arranged to simultaneously
Sizes and shape, according to use needs be replaced, the most also can sheathed collection shell to collect difference
The tubular fiber support of shape, the scope of application is wider.
Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses
The present invention.Multiple amendment to these embodiments will be aobvious and easy for those skilled in the art
See, generic principles defined herein can without departing from the spirit or scope of the present invention,
Realize in other embodiments.Therefore, the present invention is not intended to be limited to the embodiments shown herein,
And it is to fit to the widest scope consistent with principles disclosed herein and features of novelty.
Claims (9)
1. the method that a batch prepares electrostatic spinning tubular fiber support, it is characterised in that use batch
Preparing the collection device of electrostatic spinning tubular fiber support, described collection device includes chassis and many collections
Bar, described collection bar rotates and is arranged on described chassis；Described chassis includes runner and card, described dish
Being provided with rotation mouth on face, described many collection pole pairs should be installed in described rotation mouth, and can rotation；
Described runner is arranged at described card center position, and described runner is driving gear, described collection
Being fixedly installed driven gear on bar, described driving gear engages each other with described driven gear；
Runner drives card synchronous axial system under the effect of power, it is achieved collects bar and revolves round the sun around runner, with
This simultaneously, driven by rotating wheel driven gear operates, it is achieved collect the spinning motion of bar；
Method specifically comprises the following steps that
(1), choosing the collection bar of required form, surface is uniformly coated with polymeric coating layer, by multiple receipts
Collection pole pair should be installed in rotation mouth, by the chassis earth of collection device, opens rotation power supply, collects bar
There is revolution and rotation simultaneously；
(2), the electrostatic spinning ejector filling polymer electrostatic spinning solution is ready to, opens electricity
Source, carries out electrostatic spinning；
(3), electrostatic spinning ejector alignment collection device, the velocity of rotation of regulating collecting device and quiet
Electrospun parameter, collects difform tubular fiber support collecting on bar；
(4), collected after, take off collection bar, use the mode soaking the demoulding, will collect on bar
Polymeric coating layer dissolve as synovial fluid, take off electrostatic spinning tubular fiber support, be vacuum dried further.
2. the method that batch as claimed in claim 1 prepares electrostatic spinning tubular fiber support, its feature
Being, described collection bar is be uniformly distributed in described card multiple, the plurality of collection bar be positioned at
On one circumference, and the center that the center of circle is described card.
3. the method that batch as claimed in claim 1 prepares electrostatic spinning tubular fiber support, its feature
Being, described collection device also includes collecting shell, and described collection shell is dismountable is sheathed on described collection bar
On.
4. the method that batch as claimed in claim 3 prepares electrostatic spinning tubular fiber support, its feature
Being, the radius of gyration of described collection shell is 1mm-10cm.
5. the method that batch as claimed in claim 1 prepares electrostatic spinning tubular fiber support, its feature
It is, described collection bar is also arranged with collection shell, in order to collect difform tubular fiber support,
Polymeric coating layer is scribbled uniformly on described collection shell.
6. the method that batch as claimed in claim 1 prepares electrostatic spinning tubular fiber support, its feature
Being, when electrostatic spinning solution is fat-soluble macromolecule, then polymeric coating layer is water soluble polymer,
When electrostatic spinning solution is water soluble polymer, then polymeric coating layer is fat-soluble macromolecule.
7. the method that batch as claimed in claim 6 prepares electrostatic spinning tubular fiber support, its feature
Being, described water soluble polymer is polyvinylpyrrolidone, polyvinyl alcohol, chitosan, gelatin, thoroughly
Mixing of one or more in bright matter acid sodium, starch, Polyethylene Glycol, polymaleic anhydride, polyethylene glycol oxide
Compound.
8. the method that batch as claimed in claim 6 prepares electrostatic spinning tubular fiber support, its feature
Being, described fat-soluble macromolecule is polylactic acid, polylactic-co-glycolic acid, polylactic acid-polyglycol
Copolymer, polylactic acid-polycaprolactone co-polymer, polycaprolactone, poly phosphate, Merlon and condensing model
In the mixture of one or more.
9. the method that batch as claimed in claim 6 prepares electrostatic spinning tubular fiber support, its feature
Being, described water soluble polymer is polyvinylpyrrolidone analog copolymer, and described fat-soluble macromolecule is
Polylactic acid-based copolymer.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4738740A (en) * | 1985-11-21 | 1988-04-19 | Corvita Corporation | Method of forming implantable vascular grafts |
| CN101532183A (en) * | 2009-04-22 | 2009-09-16 | 南开大学 | Receiving device for bilaterally collecting electric spinning polymer fiber tubes |
| CN101994090A (en) * | 2009-08-14 | 2011-03-30 | 鸿富锦精密工业（深圳）有限公司 | Sputtering carrier and sputtering device comprising sputtering carrier |
| CN201793727U (en) * | 2010-08-03 | 2011-04-13 | 深圳市振恒昌实业有限公司 | Planet gear mouse cage type work rest |
| CN103320877A (en) * | 2013-07-09 | 2013-09-25 | 苏州大学 | Method for preparing degradable tissue engineering three-dimensional support and device for machining degradable tissue engineering three-dimensional support |
| CN103343393A (en) * | 2013-07-24 | 2013-10-09 | 苏州大学 | Electrostatic spinning device and method for three-dimensional nanofiber assembly |
-
2013
- 2013-11-22 CN CN201310597148.3A patent/CN103556239B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4738740A (en) * | 1985-11-21 | 1988-04-19 | Corvita Corporation | Method of forming implantable vascular grafts |
| CN101532183A (en) * | 2009-04-22 | 2009-09-16 | 南开大学 | Receiving device for bilaterally collecting electric spinning polymer fiber tubes |
| CN101994090A (en) * | 2009-08-14 | 2011-03-30 | 鸿富锦精密工业（深圳）有限公司 | Sputtering carrier and sputtering device comprising sputtering carrier |
| CN201793727U (en) * | 2010-08-03 | 2011-04-13 | 深圳市振恒昌实业有限公司 | Planet gear mouse cage type work rest |
| CN103320877A (en) * | 2013-07-09 | 2013-09-25 | 苏州大学 | Method for preparing degradable tissue engineering three-dimensional support and device for machining degradable tissue engineering three-dimensional support |
| CN103343393A (en) * | 2013-07-24 | 2013-10-09 | 苏州大学 | Electrostatic spinning device and method for three-dimensional nanofiber assembly |
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