CN103704684A - Bone health product - Google Patents
Bone health product Download PDFInfo
- Publication number
- CN103704684A CN103704684A CN201210376544.9A CN201210376544A CN103704684A CN 103704684 A CN103704684 A CN 103704684A CN 201210376544 A CN201210376544 A CN 201210376544A CN 103704684 A CN103704684 A CN 103704684A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- care product
- health
- collagen
- skeleton
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000037180 bone health Effects 0.000 title abstract description 7
- 102000008186 Collagen Human genes 0.000 claims abstract description 36
- 108010035532 Collagen Proteins 0.000 claims abstract description 36
- 229920001436 collagen Polymers 0.000 claims abstract description 36
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011701 zinc Substances 0.000 claims abstract description 15
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 15
- 229940088594 vitamin Drugs 0.000 claims abstract description 12
- 229930003231 vitamin Natural products 0.000 claims abstract description 12
- 235000013343 vitamin Nutrition 0.000 claims abstract description 12
- 239000011782 vitamin Substances 0.000 claims abstract description 12
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 24
- 229930003316 Vitamin D Natural products 0.000 claims description 20
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 20
- 235000019166 vitamin D Nutrition 0.000 claims description 20
- 239000011710 vitamin D Substances 0.000 claims description 20
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 20
- 229940046008 vitamin d Drugs 0.000 claims description 18
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 12
- 229930003268 Vitamin C Natural products 0.000 claims description 12
- 235000019154 vitamin C Nutrition 0.000 claims description 12
- 239000011718 vitamin C Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 11
- 239000000470 constituent Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 6
- -1 licorzinc Chemical compound 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011746 zinc citrate Substances 0.000 claims description 4
- 235000006076 zinc citrate Nutrition 0.000 claims description 4
- 229940068475 zinc citrate Drugs 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- 239000011670 zinc gluconate Substances 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 108010058643 Fungal Proteins Proteins 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 239000000905 isomalt Substances 0.000 claims description 2
- 235000010439 isomalt Nutrition 0.000 claims description 2
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- GAMIYQSIKAOVTG-UHFFFAOYSA-L zinc;2-aminopentanedioate Chemical compound [Zn+2].[O-]C(=O)C(N)CCC([O-])=O GAMIYQSIKAOVTG-UHFFFAOYSA-L 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 230000036541 health Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract description 3
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 229960002442 glucosamine Drugs 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 210000000845 cartilage Anatomy 0.000 abstract description 2
- 230000001502 supplementing effect Effects 0.000 abstract description 2
- 229960005188 collagen Drugs 0.000 abstract 2
- 210000001179 synovial fluid Anatomy 0.000 abstract 1
- 239000000047 product Substances 0.000 description 27
- 239000002245 particle Substances 0.000 description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 8
- 239000011575 calcium Substances 0.000 description 8
- 229910052791 calcium Inorganic materials 0.000 description 8
- 238000005469 granulation Methods 0.000 description 7
- 230000003179 granulation Effects 0.000 description 7
- 230000037182 bone density Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 4
- 210000000689 upper leg Anatomy 0.000 description 4
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 3
- 210000002808 connective tissue Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000011576 zinc lactate Substances 0.000 description 3
- 229940050168 zinc lactate Drugs 0.000 description 3
- 235000000193 zinc lactate Nutrition 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 210000003321 cartilage cell Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical group 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010039984 Senile osteoporosis Diseases 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 235000020964 calcitriol Nutrition 0.000 description 1
- 239000011612 calcitriol Substances 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 229960005084 calcitriol Drugs 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a bone health product, which comprises collagen, glucosamine, vitamin and zinc source. The provided bone health product organically combines the collagen, glucosamine, vitamin and zinc source together, thereby the absorption is easy; the production of proteoglycan and collagen in human body can be promoted for supplementing the joint synovial fluid, and the necessary material of cartilage tissue for recovering the health after the joint is injured can be provided, the collagen formation is promoted, calcareous absorption and production can be promoted, and the bone health product is helpful for health care effect to human bone.
Description
Technical field
The invention belongs to nutriment field, be specially a kind of skeleton health-care product.
Background technology
Maintaining of bone health is sizable associated because have with dietetic nutrition picked-up and lifestyle.For arthritis and patients with osteoporosis, be often engaged in bone and the joint care aspects such as physical labourer, sportsman or the elderly; bone health is had to higher demand; people often can take some skeleton health-care product, to delaying the degeneration in bone or joint.
Recently the relation of vitamin D and bone health also often comes into question.Vitamin D has the effect of promotion enteron aisle to calcareous absorption; And vitamin D is also relevant with the eubolism function of bone cells.But, take separately the medicines such as gucosamine, vitamin D, can not make each active ingredient work in coordination with and play a role, and dosage is restive.Current existing skeleton health-care product have the products such as glucose osamine, calcium, and liquid state, powder or chalybeate product are made with folk prescription or compound form by aforementioned gucosamine, the general system of calcium.When people are oral, a part for aforementioned liquid state, powder or chalybeate skeleton health-care product is easily for saliva is decomposed, and affect human body for the composition assimilation effect of skeleton health-care product, as for liquid and Powdered skeleton health-care product, be not easy to user and carry the defects such as oral.
Summary of the invention
The present invention's main purpose is to provide a kind of structure of skeleton health-care product, wishes therefore to solve existing skeleton health-care product and is not easy to carry oral, and easily for saliva dissolves, affects the problems such as absorption when oral.
The technical scheme that realizes above-mentioned purpose of the present invention is:
Skeleton health-care product, it comprises: collagen (Collagen), gucosamine (Glucosamine), vitamin and zinc source.
Preferably, described skeleton health-care product comprise the constituent of weight portion: the zinc source of the gucosamine of the collagen of 40-80 part, 10-20 part, the vitamin of 0.1-0.5 part and 0.05-0.5 part.
More preferably, described skeleton health-care product comprise the constituent of weight portion: the zinc source of the gucosamine of the collagen of 50-90 part, 5-10 part, the vitamin of 0.2-1 part and 0.01-0.5 part.
The formed network structure of described collagen, can be coated wherein by its cartilage cell's glucoprotein and albumen candy, and moisture is retained in network structure.The conversion of the complete and natural composition of collagen by coenzyme in body just can post-equalization, thereby Articular Cartilage and connective tissue improve the pain in joint, osteoporotic situation.
Described gucosamine is a kind of amido sugar in human body, is that the glutinous polysaccharide component (being a kind of constituent of polysaccharide body) with viscosity is present in cartilage and connective tissue everywhere, is also to form one of most important nutrient of cartilage cell.In mankind's body, can synthesize voluntarily grape amine, just, along with the increase at age, synthetic speed is unable to catch up with the speed of decomposing, then there is the phenomenon of body endoskeleton and joint shortage grape amine, and then affect the metabolism of joint inner cell.The gucosamine of selecting during skeleton health-care product composition of the present invention divides can be decomposed into amino acid in human body, can convert galactolipin to, also can convert chondroitin to, by supplementing of gucosamine, can promote the manufacture of the interior proteoglycan of body and collagen, supplement knuckle synovia, and can provide injured posterior joint to recover the necessary material of its healthy cartilaginous tissue.
Collagen can make calcareous and osteocyte combine closely can not run off, therefore can contribute to human body to delay the degeneration in bone or joint; Vitamin D can be through the further conversion calcitriol of liver and kidney, as a kind of hormone, reenter circulation, regulate the absorption of calcium and phosphorus, promote growth and the reconstruct of bone, vitamin D can be used for preventing child rickets and adult bone malacosis, and vitamin D and calcium share and can prevent senile osteoporosis; Vitamin C can promote the formation of collagen, and promotes that calcareous absorption, aforementioned collagenic protein are between the tissue and dentin cell of the connective tissue, blood vessel and the bone that are present in human body; Zinc is one of important component in the blood of human body and bone.
Wherein, described vitamin is vitamin C (Vitamin-C) and vitamin D (Vitamin-D), and the part by weight of the two is 3000-15000:1.
Preferably, the part by weight of described vitamin C and vitamin D is 5000-25000:1.
Wherein, described zinc source is one or more in zinc citrate, zinc gluconate, licorzinc, zinc glutamate, Yeast protein zinc.
Wherein, described skeleton health-care product are comprised of described active ingredient and pharmaceutically acceptable carrier or diluent solid pharmaceutical preparation or liquid preparation.
Wherein, described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, D-sorbite, isomalt, isomaltoketose, starch, dextrin, water, microcrystalline cellulose, lactose, sucrose, gelatin, HPMC, soybean oil, phosphatide, dolomol.
Wherein, described solid pharmaceutical preparation is selected from tablet, capsule, granule or pulvis, is preferably granule; Described liquid preparation is oral liquid.
A method of preparing the skeleton health-care product that the present invention proposes, it is to take in proportion collagen, gucosamine, vitamin and zinc source granulation, after the molten film of coated stomach granule.
The application of the skeleton health-care product that the present invention proposes in body-care.
Beneficial effect of the present invention is:
The skeleton health-care product that the present invention proposes are organically combined collagen, gucosamine, vitamin and zinc source, are easy to absorb; Not only can promote the manufacture of the interior proteoglycan of body and collagen, supplement knuckle synovia, can also provide injured posterior joint to recover the necessary material of its healthy cartilaginous tissue, promote the formation of collagen, and promote calcareous absorption to produce, contribute to the health care effectiveness of skeleton.
The specific embodiment
Now with following most preferred embodiment, the present invention is described, but is not used for limiting the scope of the invention.In embodiment, if no special instructions, equipment and the method for field routine under the equipment using and method are.
The gucosamine using in example of the present invention is purchased from Zhejiang Tianyi Food Additives Co., Ltd., collagen is purchased from osmanthus, Xiamen Yu Shi commerce and trade Co., Ltd, vitamin C is purchased from Xiamen Zhen Xuan trade Co., Ltd, vitamin D is purchased from Xiamen Zhen Xuan trade Co., Ltd, and zinc citrate and zinc gluconate are purchased from Xiamen Zhen Xuan trade Co., Ltd.
Embodiment 1:
Take the constituent of weight portion: 40 parts of collagens, 10 parts of gucosamines, 0.1 part vitamin C and D, wherein vitamin D accounts for 0.02wt%, the zinc citrate of 0.05 part; Stir, with granulator granulation, the particle of screening particle diameter 0.02-0.05mm, is granule.
The present invention's skeleton health-care product, it is utilization granulator granulation, the particle that sieves out particle diameter 0.4-0.8mm contains the particle that skeleton health-care becomes minute so that oral these skeleton health-care product of people, when oral by this granule mixing in water for oral taking.Until skeleton health-care product, reach after human stomach, can be gastric juice and dissolve fast, make to contain the particle that skeleton health-care becomes minute and disperse, and absorbed by human body for gastric juice dissolves, make skeleton health-care composition in particle can bring into play the health care effectiveness of its useful skeleton.
Embodiment 2:
Take the constituent of weight portion: 60 parts of collagens, 15 parts of gucosamines, vitamin C and the D of 0.3 part, wherein vitamin D accounts for 0.02wt%, the zinc lactate of 0.275 part; Stir, with granulator granulation, sieve out the particle of particle diameter 0.3-0.5mm, obtain granule.
Embodiment 3:
Take the constituent of weight portion: 80 parts of collagens, 20 parts of gucosamines, 0.5 part vitamin C and D, wherein vitamin D accounts for 0.008wt%, and the zinc acetate of 0.5 part; Stir, with granulator granulation, sieve out the particle of particle diameter 0.5-0.8mm, obtain granule.
Embodiment 4:
Take the constituent of weight portion: 70 parts of collagens, 7.5 parts of gucosamines, the vitamin C of 0.6 part and D, wherein vitamin D accounts for the zinc lactate of 0.02wt% and 0.255 part; Stir, with granulator granulation, sieve out the particle of particle diameter 0.8-0.9mm, obtain granule.
Embodiment 5
Take the constituent of weight portion: 90 parts of collagens, 10 parts of gucosamines, vitamin C and the D of 1 part; wherein vitamin D accounts for the zinc lactate of 0.005wt% and 0.5 part; add cane sugar powder to mix, granulation, dry, whole grain mix, pack, pack, and obtain granule.
Experimental example 1
For inquiring into the increase bone density effect of skeleton health-care product, basic, normal, high three dosage groups are established in experiment, separately establish a low amount collagen control group and a high collagen control group, basic, normal, high three dosage groups are respectively with 200,400,122mg/kg ﹒ bw(is equivalent to 5,10,30 times of human body RDs) the collagen compound (embodiment 1 product) of dosage.Give rat oral gavage 13WK, drink deionized water and ingest containing the feed of collagen (this skeleton health-care product), measure rat height, femur calcium content and bone density apparent absorption rate etc. and see mutually index.Result experiment high dose group animal femur mid point and distal bone density, calcium content of bone, femur weight are higher than the collagen control group of low dosage collagen control group and corresponding dosage.Conclusion: after two months, the absorptivity of calcium of taking these collagen skeleton health-care product is higher, has the effect that increases rat bone density.
Table 1: on the impact of femur weight, calcium content of bone, bone density (n=10, x ± s)
Note: △ △ represents low dosage collagen control group and the collagen control group P < 0.01 that relatively declines; *, * * represents that respectively dosage group and collagen control group relatively increase P < 0.05, P < 0.01.
Results of animal shows, health products of the present invention have obvious enhancing effect to bone.
Above embodiment is described the preferred embodiment of the present invention; not scope of the present invention is limited; design under the prerequisite of spirit not departing from the present invention; various modification and improvement that the common engineers and technicians in this area make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (10)
1. skeleton health-care product, is characterized in that, the active ingredient of these skeleton health-care product comprises: collagen, gucosamine, vitamin and zinc source.
2. skeleton health-care product as claimed in claim 1, is characterized in that, described active ingredient comprises the constituent of weight portion: the zinc source of the gucosamine of the collagen of 40-80 part, 10-20 part, the vitamin of 0.1-0.5 part and 0.05-0.5 part.
3. skeleton health-care product as claimed in claim 2, is characterized in that, described active ingredient comprises the constituent of weight portion: the zinc source of the gucosamine of the collagen of 50-90 part, 5-10 part, the vitamin of 0.2-1 part and 0.01-0.5 part.
4. skeleton health-care product as claimed in claim 1, is characterized in that, described vitamin is vitamin C and vitamin D, and the part by weight of the two is 3000-15000:1.
5. skeleton health-care product as claimed in claim 3, is characterized in that, the part by weight of described vitamin C and vitamin D is 5000-250000:1.
6. skeleton health-care product as claimed in claim 1, is characterized in that, described zinc source is one or more in zinc citrate, zinc gluconate, licorzinc, zinc glutamate, Yeast protein zinc.
7. skeleton health-care product as claimed in claim 1, is characterized in that, solid pharmaceutical preparation or liquid preparation that described skeleton health-care product are comprised of described active ingredient and pharmaceutically acceptable carrier or diluent.
8. skeleton health-care product as claimed in claim 7, it is characterized in that, described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, D-sorbite, isomalt, isomaltoketose, starch, dextrin, water, microcrystalline cellulose, lactose, sucrose, gelatin, HPMC, soybean oil, phosphatide, dolomol.
9. skeleton health-care product as claimed in claim 7, is characterized in that, described solid pharmaceutical preparation is selected from tablet, capsule, granule or pulvis, is preferably granule; Described liquid preparation is oral liquid.
10. the application of the arbitrary described skeleton health-care product of claim 1-7 in body-care.
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| CN201210376544.9A CN103704684A (en) | 2012-09-29 | 2012-09-29 | Bone health product |
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