CN103949012A - Multiple-address controllable miniature neuromuscular blockade electrical stimulation system - Google Patents
Multiple-address controllable miniature neuromuscular blockade electrical stimulation system Download PDFInfo
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- CN103949012A CN103949012A CN201410216340.8A CN201410216340A CN103949012A CN 103949012 A CN103949012 A CN 103949012A CN 201410216340 A CN201410216340 A CN 201410216340A CN 103949012 A CN103949012 A CN 103949012A
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Abstract
The invention discloses a multiple-address controllable miniature neuromuscular blockade electrical stimulation system and belongs to the field of medical apparatuses and instruments. The multiple-address controllable miniature neuromuscular blockade electrical stimulation system comprises an in-vitro controller and multiple in-vivo miniature electrical stimulators, each in-vivo miniature electrical stimulator is provided with a fixed address, the in-vitro controller controls synchronous working of each miniature electrical stimulator through an instrument and provides energy required by electrical stimulation through wireless radio frequency and transmits an electrical stimulation command. The system multiple-address controllable miniature neuromuscular blockade electrical stimulation system sends the instrument to control the synchronous working of each miniature electrical stimulator through one in-vitro controller, achieves multiple-muscle-group coordinated exercise, perfects basic exercise of a human body, effectively solves the multiple-muscle-group coordinated shrinkage problem, and solves the problem that a traditional implanted product can only simulate muscle groups and the problem of replacement operation caused by battery service life.
Description
Technical field
The invention belongs to medical instruments field, relate to the controlled miniature neuromuscular electric stimulation of a kind of multiaddress.
Background technology
Neuromuscular electricity irritation is to use low-frequency current to make the rehabilitation technique of muscle contraction, from the sixties in 20th century, be widely used in upper limb, lower limb, breathing, the motor function recovery of bladder and rectum acts on the neuromuscular function of the direct substitution human bodies of nerve prosthesis such as vision, audition simultaneously.Neuromuscular electricity irritation by the relative position difference of placing be divided into surface system, through dermal system and embedded system.Surface system is placed in electrode on skin, it is a kind of non-intrusion type, conveniently wear and win, therefore be widely used in recovering physiotherapy, and successfully for standing, mark time and hand grasp motion, but be difficult to location fritter or deep part muscle, even because repeatedly wear and win, being difficult to repeat stimulates.Through dermal system, use implant electrode, can be placed on exactly near target muscle or nerve, but percutaneous formula electrode may cause potential complication, such as residual electrode fragment causes granuloma.Embedded system is that stimulator and electrode are all injected in body, by external controller, by radio-frequency technique firing order and energy is provided, compares more convenient, more attractive in appearance, more reliably with other system, and the repeatability that applies stimulation is also better.
In recent years, embedded system is used widely aspect clinical treatment.1994, Medtronic (Medtronic) company starts development and is used for the treatment of the property stopped up sleep apnea (OSA) stimulator for implantation (Inspire II System), the pressure that this implanting device is breathed chest by monitoring sleep changes, once respiratory movement stops, manager just gives hypoglossal nerve stimulation by stimulating electrode, thereby opens upper respiratory tract.Calendar year 2001, the Loeb of American South University of California research group has been reported the neural interface-BION of reparation of single channel cylinder
tMsystem, can be used for treating dyskinesia.2008, the Li Luming of space flight and aviation institute of Tsing-Hua University developed a implanted stimulator for brain and nerve stimulation, is used for the treatment of parkinsonism.Meanwhile, U.S. Xi Chu university has developed IST12 hand system, the CWRU embedded systems such as system, VA running gear of standing.These systems have all obtained relevant food and drug administration and have authenticated, and have carried out a large amount of clinical experiments.These system embedded systems are all single channel electric stimulations, can only complete single muscle or neural stimulation.
Recently, the implanted multi-section IST12 of the patient system of C1 level paralysis, produces hand, elbow, head movement, to help patient to complete such as the daily basic task such as having a meal and clean.The coordination of many muscle groups, is the basis of human body basic motion, so multichannel implantation type electric stimulation system is the only way which must be passed of embedded system development.
Summary of the invention
In view of this, the object of the present invention is to provide the controlled miniature neuromuscular electric stimulation of a kind of multiaddress, this system is controlled a plurality of electrostimulators by a peripheral control unit by instruction and is worked asynchronously, and realizes polymyarian group coordination exercise, reaches and improves human body basic motion.
For achieving the above object, the invention provides following technical scheme:
The controlled miniature neuromuscular electric stimulation of a kind of multiaddress, comprise miniature electrical stimulator in external controller and a plurality of body, the distinguishing fixed address of miniature electrical stimulator band in every individuality wherein, external controller is controlled each miniature electrical stimulator by instruction and is worked asynchronously, and described external controller provides the needed energy of electricity irritation and transmitting electricity irritation order by less radio-frequency to miniature electrical stimulator in every one.
Further, described external controller comprises human-computer interaction module, signal projector, E class power amplification circuit and radio-frequency sending coil, and described human-computer interaction module is used for receiving extraneous function command, and is transferred to signal projector; Described signal projector produces the control instruction of function command mapping and is modulated to carrier signal, generating digital modulation signal; Described E class power amplification circuit is used for digital modulation signals to carry out power amplification, and is transferred to radio-frequency sending coil by shielding line; Described radio-frequency sending coil is for passing through near field electromagnetic field transferring energy and information towards periphery.
Further, in described body, miniature electrical stimulator comprises induction coil, power supervisor, demodulation controller, on-off circuit and Biocompatible electrodes, wherein said induction coil divides two groups, one group is energy receiving coil, for institute's induced signal is passed to power supervisor, one group is signal receiving coil, for institute's induced signal is passed to demodulation controller; Described power supervisor has been used for radiofrequency signal rectification, energy storage, filtering and voltage stabilizing, for demodulation controller, on-off circuit provide stable operating voltage; Described demodulation controller, for decoding the modulation signal receiving, generates command control word, and judges that whether this order is effective to this stimulator, if invalid, do not change existing output state, if effectively,, according to control word particular content, shine upon, export corresponding signal; Described on-off circuit is comprised of H bridge, according to the output state of demodulation controller, realizes the left and right arms conducting of H bridge, and left and right arms output is directly connected with the second electrode with the first electrode of both sides.
Further, in described body, miniature electrical stimulator is shaped as cylinder, length 10mm-15mm, diameter of 1 mm-3 mm; The first electrode of miniature electrical stimulator and the two ends that the second electrode is placed on respectively cylinder in body, the material of electrode is that miniature electrical stimulator is implanted to inside of human body in biocompatible material body, and the first electrode and the second electrode directly act on target muscle or target nerve around.
Further, the antenna of described radio-frequency sending coil be for can effectively reduce the shielding specified impedance cable of extraneous magnetisable material to the change of impedance operator own,
Further, described induction coil is the multiturn coil with magnetic core, and the material of magnetic core is ferrite.
Further, the frequency of carrier signal of system is 6.78MHz; The energy receiving coil of induction coil and the resonant frequency of signal receiving coil are all frequency of carrier signal.
Further, the control instruction that external controller sends is to consist of three bytes, comprises address code, order code and identifying code.
Beneficial effect of the present invention is: the controlled miniature neuromuscular electric stimulation of multiaddress described in the embodiment of the present invention is to adopt the networking type multi-channel synchronous of energy together with signal wireless transmission collection to implant electricity irritation, compared with prior art, the embodiment of the present invention has effectively solved a plurality of muscle groups and has coordinated contraction problem, having overcome traditional implantable products can only stimulate the problem of single muscle group, and conventional bulk internal stimulus device is because the replacing Operation that battery life causes.The present invention is suitable for motor function recovery, is also suitable for substituting the nerve prosthesis of some neuromuscular function, has better safety and practicality, can bring good practical value, social value and economic worth.
Accompanying drawing explanation
In order to make object of the present invention, technical scheme and beneficial effect clearer, the invention provides following accompanying drawing and describe:
Fig. 1 is the overall structure schematic diagram of the controlled miniature neuromuscular electric stimulation of the multiaddress of the embodiment of the present invention;
Fig. 2 is that theory diagram and the signal energy of the controlled miniature neuromuscular electric stimulation of the multiaddress of the embodiment of the present invention moved towards figure;
Fig. 3 is the power supervisor theory diagram of the interior miniature electrical stimulator of body of the controlled miniature neuromuscular electric stimulation of the multiaddress of the embodiment of the present invention;
Fig. 4 is the demodulation controller theory diagram of the interior miniature electrical stimulator of body of the controlled miniature neuromuscular electric stimulation of the multiaddress of the embodiment of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
The controlled miniature neuromuscular electric stimulation of multiaddress that the present invention proposes, controls a plurality of electrostimulators by a peripheral control unit by instruction and works asynchronously, and realizes polymyarian group coordination exercise, reaches and improves human body basic motion.Fig. 1 is the overall structure schematic diagram of the controlled miniature neuromuscular electric stimulation of the multiaddress of the embodiment of the present invention, comprise a plurality of miniature electrical stimulators 20 in external controller 10 and a plurality of body, in every individuality, miniature electrical stimulator 20 is with distinguishing fixed address, external controller is controlled each miniature electrical stimulator by instruction and is worked asynchronously, and external controller 10 provides the needed energy of electricity irritation and transmitting electricity irritation order by less radio-frequency to miniature electrical stimulator 20 in every one.
Fig. 2 is that theory diagram internal structure and the signal energy of the controlled miniature neuromuscular electric stimulation of the multiaddress of the embodiment of the present invention moved towards figure; The left side is the theory diagram of external controller, comprise human-computer interaction module 101, signal projector 102 and E class power amplification circuit 103 and radio-frequency sending coil 104, human-computer interaction module is used for receiving extraneous function command, and is transferred to signal projector 102; Signal projector 102 produces the control instruction of function command mapping and is modulated to carrier signal, generating digital modulation signal; E class power amplification circuit 103 is for digital modulation signals is carried out to power amplification, and is transferred to radio-frequency sending coil 104 by shielding line; Radio-frequency sending coil 104 is for passing through near field electromagnetic field transferring energy and information towards periphery.Wherein E power-like amplifier 103 is core circuits of peripheral control unit 10, this circuit adopts single tube fet power pipe as switching device, realize radio frequency low-loss digital signal to the transformation of analogue signal, then through resonance matching network sine wave output, be carried in radio-frequency sending coil.Radio-frequency sending coil 104, for shielding specified impedance cable, can reduce the change of extraneous magnetisable material to impedance operator own effectively.
The right of Fig. 2 is the internal structure theory diagram of miniature electrical stimulator in body.In every one, the structure of miniature electrical stimulator is identical, is all by induction coil 201, and power supervisor 202, demodulation controller 203, on-off circuit 204 and Biocompatible electrodes form.In body, the encapsulating structure of miniature electrical stimulator is cylinder, and cylindrical length is at 10mm-15mm, and diameter is at 1mm-3mm, as shown in Fig. 1 dotted line frame.The first electrode 206 and the second electrode 207 are placed respectively at the two ends of cylinder, and the material of electrode is biocompatible material, can be specifically titanium alloy, or titanium; Miniature electrical stimulator is implanted to inside of human body in body, and the first electrode 206 and the second electrode 207 directly act on target muscle or target nerve around.
Wherein induction coil 201 is the multiturn coil with magnetic core, and the material of magnetic core is ferrite, the network of formation 6.78MHz resonant frequency in parallel with low loss capacitance.Multiturn coil divides two groups, and one group is energy receiving coil, and institute's induced signal passes to power supervisor 202, and the enamel-covered wire diameter being wound on above it wants thick.Another group is signal receiving coil, and institute's induced signal passes to demodulation controller 203, and the enamel-covered wire diameter outline being wound on above it is thin.
On-off circuit 204 is comprised of H bridge, according to the output state of demodulation controller, realizes the left and right arms conducting of H bridge, and left and right arms output is directly connected with the second electrode 207 with the first electrode 206 of both sides.
Power supervisor 202 completes radiofrequency signal rectification, energy storage, filtering and voltage stabilizing, and for demodulation controller 203, on-off circuit 204 provide stable operating voltage, theory diagram as shown in Figure 3.Power supervisor 202 is high-frequency electrical pressure reduction diode rectification for coil-induced radio frequency sinusoidal signal, production burst d. c. voltage signal; Pulse direct current signal carries out filtering again through high frequency capacitance, obtains the direct current signal that ripple is larger, and this direct current signal has two paths, and one is to energy-storage travelling wave tube storage of electrical energy, and one is to make mu balanced circuit obtain burning voltage.When body inner inductive coil does not provide the voltage of high-frequency electrical pressure reduction diode current flow, energy-storage travelling wave tube directly provides energy to mu balanced circuit through filtering.
Demodulation controller 203 is decoded the modulation signal receiving, and generates command control word, and judges that whether this order is effective to this stimulator, if invalid, do not change existing output state, if effectively,, according to control word particular content, shine upon, export corresponding signal, theory diagram as shown in Figure 4.Demodulation controller 203 gets coil signal from induction coil 201, through demodulator circuit, obtain perfect information analogue signal, after signal transformation circuit, obtain the digital signal of external controller transmitting, utilize address recognition circuit and fixed address contrast, obtain command signal, again through command mapping, controlled signal.In this concrete application example, demodulation controller is to realize with the commercial single-chip microcomputer nude film that is loaded with firmware.
Improvement as the embodiment of the present invention, the power supervisor of miniature electrical stimulator in body 202, demodulation controller 203 and on-off circuit 204 all can be integrated into ASIC (Application Specific Integrated Circuit, integrated circuit) above, reach a nearly step and reduce miniature electrical stimulator size and the object that reduces power consumption in body.
Finally explanation is, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can to it, make various changes in the form and details, and not depart from the claims in the present invention book limited range.
Claims (9)
1. the controlled miniature neuromuscular electric stimulation of multiaddress, it is characterized in that, comprise miniature electrical stimulator in external controller and a plurality of body, the distinguishing fixed address of miniature electrical stimulator band in every individuality wherein, external controller is controlled each miniature electrical stimulator by instruction and is worked asynchronously, and described external controller provides the needed energy of electricity irritation and transmitting electricity irritation order by less radio-frequency to miniature electrical stimulator in every one.
2. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 1, it is characterized in that, described external controller comprises human-computer interaction module, signal projector, E class power amplification circuit and radio-frequency sending coil, described human-computer interaction module is used for receiving extraneous function command, and is transferred to signal projector; Described signal projector produces the control instruction of function command mapping and is modulated to carrier signal, generating digital modulation signal; Described E class power amplification circuit is used for digital modulation signals to carry out power amplification, and is transferred to radio-frequency sending coil by shielding line; Described radio-frequency sending coil is for passing through near field electromagnetic field transferring energy and information towards periphery.
3. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 1 and 2, it is characterized in that, in described body, miniature electrical stimulator comprises induction coil, power supervisor, demodulation controller, on-off circuit and Biocompatible electrodes, wherein said induction coil divides two groups, and one group is energy receiving coil, for institute's induced signal is passed to power supervisor, one group is signal receiving coil, for institute's induced signal is passed to demodulation controller; Described power supervisor has been used for radiofrequency signal rectification, energy storage, filtering and voltage stabilizing, for demodulation controller, on-off circuit provide stable operating voltage; Described demodulation controller, for decoding the modulation signal receiving, generates command control word, and judges that whether this order is effective to this stimulator, if invalid, do not change existing output state, if effectively,, according to control word particular content, shine upon, export corresponding signal; Described on-off circuit is comprised of H bridge, according to the output state of demodulation controller, realizes the left and right arms conducting of H bridge, and left and right arms output is directly connected with the second electrode with the first electrode of both sides.
4. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 1 and 2, is characterized in that, in described body, miniature electrical stimulator is shaped as cylinder, length 10mm-15mm, diameter of 1 mm-3 mm; The first electrode of miniature electrical stimulator and the two ends that the second electrode is placed on respectively cylinder in body, the material of electrode is that miniature electrical stimulator is implanted to inside of human body in biocompatible material body, and the first electrode and the second electrode directly act on target muscle or target nerve around.
5. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 3, is characterized in that, in described body, miniature electrical stimulator is shaped as cylinder, length 10mm-15mm, diameter of 1 mm-3 mm; The first electrode of miniature electrical stimulator and the two ends that the second motor is placed on respectively cylinder in body, the material of electrode is that miniature electrical stimulator is implanted to inside of human body in biocompatible material body, and the first electrode and the second electrode directly act on target muscle or target nerve around.
6. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 2, is characterized in that, the antenna of described radio-frequency sending coil be for can effectively reduce the shielding specified impedance cable of extraneous magnetisable material to the change of impedance operator own,
7. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 3, is characterized in that, described induction coil is the multiturn coil with magnetic core, and the material of magnetic core is ferrite.
8. according to the controlled miniature neuromuscular electric stimulation of the multiaddress described in claim 3 or 7, it is characterized in that, the frequency of carrier signal of system is 6.78MHz; The energy receiving coil of induction coil and the resonant frequency of signal receiving coil are all frequency of carrier signal.
9. the controlled miniature neuromuscular electric stimulation of multiaddress according to claim 1, is characterized in that, the control instruction that described external controller sends is to consist of three bytes, comprises address code, order code and identifying code.
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| CN201410216340.8A CN103949012A (en) | 2014-05-21 | 2014-05-21 | Multiple-address controllable miniature neuromuscular blockade electrical stimulation system |
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Cited By (4)
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| CN105488987A (en) * | 2016-01-19 | 2016-04-13 | 东南大学 | Source-free wireless micromechanical switch array control system |
| CN105899029A (en) * | 2014-08-27 | 2016-08-24 | 杭州承诺医疗科技有限公司 | Packaging structure and method of injectable nerve stimulator |
| CN105879216A (en) * | 2014-08-27 | 2016-08-24 | 杭州承诺医疗科技有限公司 | Wireless charge controllable nerve stimulator and device |
| CN109818487A (en) * | 2019-02-03 | 2019-05-28 | 大悦创新（苏州）医疗科技股份有限公司 | H-bridge circuit and neuromuscular electric stimulation device with it |
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