CN104125817A - 用于置换或修复心脏瓣膜的锚定装置和方法 - Google Patents

用于置换或修复心脏瓣膜的锚定装置和方法 Download PDF

Info

Publication number
CN104125817A
CN104125817A CN201280070351.9A CN201280070351A CN104125817A CN 104125817 A CN104125817 A CN 104125817A CN 201280070351 A CN201280070351 A CN 201280070351A CN 104125817 A CN104125817 A CN 104125817A
Authority
CN
China
Prior art keywords
valve
anchor
ring
middle body
lobule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201280070351.9A
Other languages
English (en)
Other versions
CN104125817B (zh
Inventor
B·S·康克林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Edwards Lifesciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp
Publication of CN104125817A publication Critical patent/CN104125817A/zh
Application granted granted Critical
Publication of CN104125817B publication Critical patent/CN104125817B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2463—Implants forming part of the valve leaflets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457—Chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility

Abstract

公开了一种用于在心脏中锚定人工心脏瓣膜或瓣环成形环到瓣膜环的装置和将其植入的方法。该装置可以包括人工瓣膜或瓣环成形环，其中一个或多个锚经配置以便在原生小叶和/或瓣下组织下面穿过或以其他方式通过，以固定该装置在原生环处。

Description

用于置换或修复心脏瓣膜的锚定装置和方法
相关申请
本申请要求2011年12月21提交的美国临时申请No.61/578,758的优先权，其全部公开内容通过引用并入本文。
技术领域
本发明一般地涉及心脏瓣膜修复和置换。更具体地，本发明涉及经配置用于迅速植入的人工心脏瓣膜和瓣环成形环的锚定装置和方法，以及用于植入其的方法。
背景技术
心脏是一种略呈锥形的中空的肌肉器官；其位于中纵隔中的肺之间并且包封在心包中。心脏倾斜地靠在胸骨体后并且邻接肋软骨各部分的胸中，并且通常伸入胸腔左半中比伸入胸腔右半中更远，使得约三分之一位于正中平面的右侧上并且三分之二位于正中平面的左侧上。心脏由隔片细分成左右两半，并且结(constriction)将该歧管的每一半细分成两个腔，即称为心房的上腔和称为心室的下腔。因此，心脏由四个腔室组成：右和左心房以及右和左心室，单向流动瓣膜在各个心房和心室之间并且在来自心室的出口处。
房室心脏瓣膜(即三尖瓣和二尖瓣)位于心脏的心房和心室之间的心脏中心中，并且在维持血液的向前流动中起重要作用。房室瓣功能失调通常也称为“反流”并且在全球影响超过一百万人。二尖瓣和三尖瓣由每个都称为环的胶原蛋白的纤维环限定，这形成心脏的纤维骨架的一部分。该环提供用于二尖瓣的两个尖或小叶(称为前和后尖)和三尖瓣的三个尖或小叶的外周附接。小叶的自由边缘从一个以上的乳头肌连接到腱索。在健康的心脏中，这些肌肉及其腱索支持二尖瓣和三尖瓣，允许小叶抵抗在左和右心室的收缩(泵出)过程中产生的高压。
虽然瓣膜反流通常由于瓣膜环的膨胀而发生，但是二尖瓣和三尖瓣功能和能力常常取决于瓣膜的支撑结构——如关联的瓣下结构(subvalvular apparatus)——的精细几何和功能完整性。除其他外，这些心脏瓣膜的瓣下结构包括关联的腱索和乳头肌。
如图1和图2中看到的，二尖瓣(MV)是分离左心房(LA)和左心室(LV)的结缔组织的两小叶(或二尖)结构。二尖瓣作用是维持血液流动在一个方向上，即在心室放松或者舒张过程中从左心房朝向左心室，同时在心室挤压或者收缩过程中防止在相反方向上回流。前叶(AL)和后叶(PL)由前连合处(AC)和后连合处(PC)分离。两个瓣膜小叶的基部被附接到称为二尖瓣环(AN)的心脏的圆形纤维结构，并且小叶自由边缘附接到从左心室的乳头肌产生的腱索。前叶(AL)比较大并且附接到环的前段，而后叶(PL)较小但进一步周向地延伸并且附接到环的后段。该后叶呈现标识为P1、P2、P3的三个扇形，而前叶的相应非扇形部分根据卡彭铁尔的分段法(Carpentier’ssegmentation)标识为A1、A2、A3。
三尖瓣也具有瓣下结构，但是是与二尖瓣的二尖结构相对的三尖(即三个尖或小叶)结构。一些二尖瓣和三尖瓣置换过程包括除去这些瓣下结构。然而，瓣下结构可在维持心室的适当形状中发挥作用，并且因此其保存可以是期望的，这取决于特定情况。
当左心室在填充有来自左心房的血液后收缩时，该心室的壁向内移动并且释放一些来自乳头肌和腱索的张力。贴着二尖瓣小叶的下表面向上推动的血液引起其朝向二尖瓣的环面上升。随着后叶和前叶的前缘朝向所述环前进，后叶和前叶的前缘聚集在一起形成密封并且关闭该瓣膜。在健康的心脏中，小叶接合发生在二尖瓣环的平面附近。血液继续在左心室中被增压，直到其喷入主动脉中。乳头肌的收缩与该心室的收缩是同时发生的，并且用于保持健康的瓣膜小叶在由该心室施加的最高收缩压力下紧闭。
原生心脏瓣膜(如主动脉瓣、肺动脉瓣、三尖瓣和二尖瓣)在确保充足血液供应穿过心血管系统的向前流动中发挥关键作用。这些心脏瓣膜可以由于先天状况、发炎状况、感染状况或其他疾病被呈现效果较差。对瓣膜的这种损害可以导致严重的心血管损害。心脏瓣膜疾病是一种普遍状况，在这种普遍状况中，心脏的一个或多个瓣膜无法正常起作用。患病的心脏瓣膜可归类为狭窄的，其中该瓣膜不充分打开来允许血液穿过瓣膜的充分向前流动，和/或机能不全的，其中当小叶应该接合在一起来防止反流时，该瓣膜不完全关闭，造成穿过该瓣膜的血液的过多向后流动或反流。如果不及时治疗，瓣膜疾病可以严重地使人衰弱，并且甚至致命。多年来，此类病症的确定性治疗是在例如心脏直视手术(open heart surgery)过程中该瓣膜的手术修复或置换。
各种手术技术可用于修复患病或受损瓣膜，这通常用在最小钙化瓣膜上。原生瓣膜的手术修复通常使用所谓的瓣环成形环进行。瓣环成形环的示例，包括用于修复原生瓣膜的使用方法公开于1976年4月9日提交的题为“Support for a Natural Heart Valve”的美国专利号4,055,861；1989年11月30日提交的题为“Flexible Annuloplasty Ringand Holder”的美国专利号5,041,130；2001年3月6日提交的题为“Annuloplasty Ring Delivery Method”的美国专利号6,558,416；和2011年2月2日提交的题为“Devices and Methods for Treating a Heart”的共同未决的美国专利申请序列号13/019,506，其中每一个的全部内容通过引用并入本文。
有时心脏瓣膜的实际置换是优选的选择。当原生心脏瓣膜变窄，通常称为狭窄时，或者当原生瓣膜泄漏或反流时，如当小叶被钙化时，可指示进行心脏瓣膜置换。由于主动脉狭窄和其他心脏瓣膜疾病，数千名患者每年接受手术治疗，其中有缺陷的原生心脏瓣膜由人工生物的或机械的人工瓣膜置换。多年来使用人工心脏瓣膜治疗心脏瓣膜病症。
当置换瓣膜时，人工瓣膜的手术植入通常要求开胸手术，在开胸手术过程中，心脏停止并且将患者放置在心肺旁路(所谓的“心脏-肺机器”)上。在一个普通的外科手术过程中，切除患病的原生瓣膜小叶，并且缝合人工瓣膜到瓣膜环处的周围组织。由于与该过程相关联的创伤和伴随的体外血液循环的持续时间，一些患者未渡过该手术过程或在手术后不久死亡。众所周知的是，患者的风险随对体外循环要求的时间量增加。由于这些风险，相当数量的带有缺陷瓣膜的患者被视为是不能手术的，因为他们的状况太脆弱而不能承受该手术过程。通过一些估计，遭受主动脉狭窄的约30％至50％的80岁以上对象不可以进行主动脉瓣膜置换手术。
由于与常规心脏直视手术相关联的缺点，经皮和微创手术方法正引起强烈关注。在一种技术中，人工瓣膜配置为通过导管插入术的方式在更少侵入性手术过程中被植入。例如，安德森(Andersen)等人的美国专利号5,411,552描述了一种可折叠瓣膜，该可折叠瓣膜穿过导管在压缩状态下经皮引入并且通过球囊膨胀在期望位置膨胀。虽然这些远程植入技术已经示出对于治疗某些患者的很大承诺，但是经由手术介入置换瓣膜仍然是优选的治疗方法。接受远程植入的一个障碍是来自医生的抵抗，这些医生可理解地对从有效——如有疏漏——方法转换成有望有很好的结果但比较外来的新颖方法存在担忧。连同由外科医生在切换到新的心脏瓣膜置换技术时具有的可理解的谨慎，世界各地的监管机构也动作缓慢。许多成功临床试验和后续研究正在进行之中，但是在其被完全接受之前需要关于这些新技术的更多经验。
在一些情况下，原生心脏瓣膜与人工心脏瓣膜的置换可以是期望的治疗。每年有大约60,000次二尖瓣置换(MVR)，并且据估计由于增加的手术的风险和年龄，另外60,000名患者应该接受MVR。大部分的这些置换是通过心脏直视手术完成的，其中人工心脏瓣膜通过手术在肺旁路上与患者进行植入。此类手术植入的人工瓣膜有一个长期的和可靠的记录，具有在此类瓣膜置换之后记下的高成功率和临床改善。然而，保持患者花费在肺旁路上的时间为最小可以是可取的。
外科医生叙述到，当在心脏直视手术或微创心脏瓣膜植入(例如，穿过小切口)中尝试瓣膜修复或置换时的最困难任务之一是系保持该瓣膜或修复环在适当位置的缝线结。典型的人工二尖瓣植入物利用均匀分布在缝合环周围且在该缝合环一侧上手动打结的12-24条缝线(通常约15条)。当瓣膜坐落(parachute)到位置上时，由于许多对需要精确放置在环中的缝线以及通常用于固定缝线的结，植入过程可以非常耗时并且难以执行，特别是穿过最小尺寸切口。类似地，在瓣膜修复过程中，许多对缝线必须精确地放置在原生环周围，以附接修复装置。最小化或者甚至消除使用缝线(和/或系缝线结)用于人工瓣膜或修复装置附接的需要将极大地减少该手术过程的时间和/或促进使用较小切口，从而降低感染风险，减少输血的需要，减少在旁路上花费的时间，并且允许更快速的恢复。
因此，需要一种改进的装置和相关使用方法，其中人工瓣膜或瓣膜修复装置可以以在减少体外循环和/或导管插入上所需时间的更有效手术过程中植入。此类装置和方法能够帮助被视为不可手术的有缺陷瓣膜的患者是可取的，因为它们的状况太脆弱而不能承受长时间的常规手术过程。本发明解决了这些需要以及其他需要。
发明内容
公开了用于在原生瓣膜环处植入的瓣膜修复或置换装置以及植入其的方法。该装置可以是人工瓣膜、瓣环成形环或用于在原生瓣膜环处植入的其他装置。该装置具有中央部分，一个或多个锚从固定到该中央部分的固定端从其延伸，锚在自由端处终止。锚以弯曲的方式基本上平行于中央部分的周缘定位(run)，在锚和中央部分之间形成小叶接收槽。该装置配置为布置在原生瓣膜环处，并且然后被旋转(扭转)以便放置锚在原有瓣膜小叶下面，原有瓣膜小叶滑入小叶接收槽中，直到装置完全就位。然后将小叶保持在槽内，这可包括来自在锚臂和装置的中央部分之间按压小叶的锚臂的向内压力。
锚可以从中央部分延伸，并且可包括横截面，该横截面配置为具有与平面外刚性不同的平面内刚性。可以存在从中央部分延伸的一个、两个、三个、四个或更多锚。锚可以在围绕其周缘的不同位置处从中央部分延伸，并且可以大体上等距地围绕周缘布置。锚可以由金属或聚合物或其他合适的材料形成，并且装置可包括布覆盖物。该装置可包括不透射线标记(radiopaque marker)和其他结构，以增强在植入过程中的可视性。例如，锚构件可具有一个或多个布置在其上的不透射线标记，如在自由端的尖端处和/或在固定端处。
组件可形成由支撑架和瓣膜小叶形成的人工瓣膜，支撑架具有中央部分和一个或多个从其延伸的弯曲锚，以在锚(一个或多个)和中央部分之间形成至少一个槽，其中至少一个槽具有合适尺寸，以滑动地在其中接收心脏瓣膜小叶的近端部分。锚和槽可优选地具有合适尺寸并且配置为接合原有小叶。例如，至少一个槽可具有的宽度尺寸与原生瓣膜小叶的厚度类似。
根据本发明实施方式的用于治疗心脏的装置包括人工瓣膜，其具有支撑架和瓣膜部分。瓣膜部分可包括多个小叶，该多个小叶固定到支撑架并且配置为接合以允许血液以第一方向流经瓣膜部分并且防止血液以第二方向流经瓣膜部分，其中第一方向与第二方向相反，其中支撑架包括一个或多个附接结构，其配置为附接到处于或邻近原生心脏瓣膜的环的组织，和/或以其他方式促进该装置附接到处于或邻近原生心脏瓣膜的环的组织。
人工瓣膜可通过传统心脏直视技术或微创技术、和/或通过导管插入被配置用于外科手术植入。支撑架可具有补充附接结构(即，除锚以外)，用于固定人工瓣膜在原生心脏瓣膜环处的期望位置处。例如，支撑架可包括配置为缝合到原生心脏瓣膜的环的组织的缝合环，和/或可包括配置为不使用(或使用最少)缝线固定支撑架在瓣膜环处的其他附接结构，比如可膨胀支架结构、夹具、裙部或其他配置为接合原生环的组织或邻近原生环的组织以便固定人工瓣膜在期望位置处的元件。无缝合固定装置的示例和与本发明一起使用的方法公开在2010年6月23日提交的题为“Unitary Quick-Connect Prosthetic Heart Valve andDeployment System and Methods”的美国专利申请序列号12/821,628中，并且还公开在2011年6月23日提交的题为“Systems and Methods forRapidly Deploying Surgical Heart Valves”的美国专利申请序列号13/167,639中，其中每一个的全部内容通过引用明确地并入本文。
本发明的实施方式是用于置换原有心脏瓣膜的人工心脏瓣膜组件，其包括人工瓣膜和从其延伸的锚。人工瓣膜可具有支撑架和瓣膜部分。瓣膜部分是单向瓣膜，其可具有多个小叶，该多个小叶绕人工瓣膜到内部流动腔的中心轴固定到支撑架，并且配置为接合以允许血液以第一方向流经内部流动腔并且防止血液以第二方向流经内部流动腔。人工瓣膜具有外表面，其可配置为接合心脏的组织。至少一个锚构件从支撑架延伸，锚构件包括固定到支撑架的近端固定端以及远端自由端。锚构件至少部分地围绕人工瓣膜的周缘(绕其中心轴径向地)延伸，并且基本上平行于人工瓣膜外部，以限定小叶接收槽，该小叶接收槽配置为滑动地接收心脏瓣膜的小叶。小叶接收槽以连续的不间断的方式从锚构件的近端固定端延伸到锚构件的远端自由端。该槽具有合适尺寸并且配置为滑动地接收并且保持原有瓣膜的期望瓣膜小叶，其中原有瓣膜是原生心脏瓣膜或者先前植入的人工瓣膜。根据特定应用，槽可具有0.25至3.5英寸的长度和0.005至0.25英寸的宽度。
人工瓣膜可以基本上是管状的，外表面绕其周缘形成基本上连续的弯曲表面，锚构件形成曲线，该曲线平行于瓣膜的外表面的弯曲表面。
根据本发明的瓣膜组件可形成具有第一和第二锚构件的人工二尖瓣组件，该第一和第二锚构件限定第一和第二小叶接收槽并且分别具有第一和第二固定端以及第一和第二自由端。每个槽以连续的不间断的方式从锚固定端延伸到锚自由端。锚可以具有合适尺寸并且被布置以接合原生二尖瓣的前叶和后叶，使得槽具有合适尺寸以接收这些小叶。第一和第二锚可具有固定端，其绕装置的周缘被间隔开至少90度，并且更具体地约100度至140度并且更具体地120度，其中锚绕装置的周缘以相同的旋转方向(例如，顺时针方向)延伸。第一锚构件可围绕人工瓣膜的周缘穿过至少90度的角度，第二锚围绕人工瓣膜的周缘穿过至少120度的角度。
根据本发明的组件可形成瓣环成形环，其具有带有周缘的支撑环并且包括中心开口、围绕支撑环的覆盖物和第一锚构件，所述中心开口限定流体可流经其的流动轴，所述覆盖物包括外表面，所述第一锚构件从支撑架延伸。第一锚可具有固定到支撑环的第一近端固定端以及第一远端自由端，其中第一锚构件至少部分地围绕支撑环的周缘延伸并且基本上平行于覆盖物的外表面，以限定第一小叶接收槽，其配置为接收心脏瓣膜的小叶。第一小叶接收槽可优选地以连续的不间断的方式从第一近端固定端延伸到第一远端自由端。第一锚构件可围绕人工瓣膜的周缘延伸穿过至少90度的角度。
瓣环成形环可进一步包括额外的锚构件。例如，其可包括具有固定到支撑环的第二近端固定端和第二远端自由端的第二锚构件，其中第二锚构件至少部分地围绕瓣环成形环的周缘延伸并且基本上平行于其外部以限定第二小叶接收槽，其配置为接收心脏瓣膜的第二小叶。第二小叶接收槽可以以连续的不间断的方式从第二近端固定端延伸到第二远端自由端。第二近端固定端可以周向地从第一锚近端固定端位移至少90度的角度、100和140度之间的角度或约120度的角度。第一锚可围绕瓣环成形环的周缘延伸穿过90和120度之间的角度，并且第二锚可围绕瓣环成形环的周缘延伸穿过150和240度之间的角度。支撑环可以基本上是圆形的、基本上是D形的和/或基本上是鞍形的。
在原生瓣膜环处植入装置(例如，瓣环成形环、人工瓣膜等)的方法可以包括提供包括中央部分、第一弯曲锚、第二弯曲锚的装置，所述第一弯曲锚从固定到中央部分的第一固定端延伸并且大体上平行于其外表面穿过到第一弯曲锚的第一自由端，以形成第一小叶接收槽，所述第二弯曲锚从固定到中央部分的第二固定端延伸并且大体上平行于其外表面穿过到第二自由端，以形成第二小叶接收槽，其中中央部分限定流动轴穿过其中的流动孔口。方法可包括：用第一弯曲锚和第二弯曲锚布置装置邻近原生瓣膜环，装置的流体流动轴大体上平行于穿过原生瓣膜环的流体流动路径，并且将第一自由端布置邻近原生瓣膜环处的原有瓣膜的第一连合处；放置第一自由端在第一原有瓣膜小叶下面；基本上绕其流体流动轴旋转装置以推进第一自由端在第一原有瓣膜小叶下面并且从而滑动地推进第一原有瓣膜小叶进入第一小叶接收槽中；监视第二自由端相对于原有瓣膜的第二连合处的位置；以及一旦第二自由端邻近原有瓣膜的第二连合处，停止装置绕流体流动轴的旋转。一旦第二自由端邻近第二连合处，外科医生或其他使用者可以放置第二自由端在第二原有瓣膜小叶下面；重新开始基本上绕其流体流动轴旋转装置，以推进第二自由端在第二原有瓣膜小叶下面并且从而滑动地推进第二原有瓣膜小叶进入第二小叶接收槽中，同时也进一步推进第一自由端在第一原有瓣膜小叶下面并且进一步滑动地推进第一原有瓣膜小叶进入第一小叶接收槽中；以及当第一原有瓣膜小叶在邻近第一固定端的位置处滑动地推进进入第一小叶接收槽中时，停止旋转装置，由此完成装置的部署。
原生瓣膜环可以是二尖瓣环或三尖瓣环。如果原生环是三尖瓣环，装置可包括三个围绕装置的周长隔开的锚，每个锚配置为滑动地接收原有三尖瓣的三个瓣膜小叶中的一个。在原生瓣膜环是带有完整的原生二尖瓣小叶的二尖瓣环的情况中，第一连合处可以是原生二尖瓣的PC连合处，第一小叶可以是原生二尖瓣的前叶，第二连合处可以是原生二尖瓣的AC连合处，并且第二小叶可以是原生二尖瓣的后叶。
植入装置的方法包括心脏直视手术，包括其中在布置装置邻近原生瓣膜环之前的手术，外科医生或其他使用者暂时地停止心脏的心脏功能并且将患者放置在心肺旁路上。在完成装置的部署之后可以恢复心脏的心脏功能，并且然后从心肺旁路移走患者。
本发明的方法包括提供瓣膜修复或置换装置。装置可包括瓣环成形环，一个或多个锚从其延伸，或者可包括人工瓣膜，其具有支撑架和小叶，小叶固定到支撑架以形成单向瓣膜结构，并且一个或多个锚从支撑架延伸。每个锚具有固定到支撑架的近端和自由远端，槽被限定在支撑架和锚之间。锚邻近原生瓣膜的连合点布置，并且自由端被布置在瓣膜的原生小叶下面(并且在原生心脏瓣膜环下面)。装置(例如，瓣环成形环或人工心脏瓣膜)绕其中心轴旋转以推进锚在原生小叶下面，使得原生小叶被滑动地推进进入槽中。推进和固定可以在心脏直视或微创手术过程中执行。中央部分(例如，环部分或支撑架)可包括缝合环，并且固定支撑架到原生心脏瓣膜环的组织可包括将缝合环缝合到原生心脏瓣膜环的组织。装置可包括支架，在锚(一个或者多个)在原有小叶下面旋转之前、之中或之后，支架被膨胀以便与原生组织接触。原生瓣膜环可以是任何心脏瓣膜的原生瓣膜环，具体应用于二尖瓣和三尖瓣。
在将中央部分固定到原生瓣膜环之后，外科医生或其他使用者可添加一根或多根缝线或者其他固定装置/方法以固定装置到局部组织，以便防止装置向后旋转离开其部署的位置。在这样的部署中，锚保持装置以防止向上运动、向下运动、侧向运动等，而缝线或其他组织连接器用于防止装置旋转，使得小叶旋转地滑动离开槽以从锚释放。
方法可包括暂时地停止心脏的心脏功能和将患者放置在心肺旁路上，执行各种步骤(比如推进和固定人工瓣膜到原生环)，并且然后恢复心脏的心脏功能并且从心肺旁路移走患者。装置的部署可以随旁路上的患者进行，或者可以随患者的心脏跳动(例如，在从旁路移走患者之后，随重新开始的心脏功能)进行，并且随外科医生或其他使用者当进行长度调整时监测心脏功能和/或心室形状而进行。
本发明的方法可包括在固定支撑架到原生心脏瓣膜环的组织之前从心脏除去一些原生瓣膜小叶和/或瓣下结构(例如，腱索)。
本发明的前述和其他目的、特征和优点将由下列详细描述变得更显而易见，这参照附图进行。
附图说明
图1是人心脏的左侧的横截面图，其示出通过二尖瓣与左心室分开的左心房；
图2是处于闭合位置的二尖瓣的外科医生的视图或平面图，其图解了附接到环(AN)的前叶(AL)和后叶(PL)，并且指示可识别的小叶段；
图3是根据本发明实施方式的装置的实施方式的底视图；
图4和图5是根据本发明实施方式的部署在心脏中的装置的实施方式的透视图(以局部横截面)和顶视图；
图6A-6C是根据本发明的部署在二尖瓣环中的装置的顶视图；
图7A-7D分别是根据本发明实施方式的人工心脏瓣膜的侧视图、底视图、透视图和顶视图；
图8A和图8B是根据本发明实施方式的装置的侧视图；
图9A和图9B是根据本发明实施方式的装置的透视图和特写横截面图；
图10是根据本发明实施方式的装置的透视图；
图11是根据本发明实施方式的装置的顶视图；
图12是根据本发明实施方式的装置的顶视图；
图13是根据本发明实施方式的装置的透视图；
图14A-14B是根据本发明实施方式的装置的透视图；以及
图15是根据本发明实施方式的装置的顶视图。
具体实施方式
本发明是锚定装置，其包括人工心脏瓣膜和瓣环成形环以及使用该锚定装置用于固定在患者体内——比如在人心脏中的原生心脏瓣膜环——中的其他装置。该装置对固定在瓣膜(如二尖瓣和三尖瓣)的环处的装置具有特定适用性，该瓣膜具有瓣下结构比如腱索。二尖瓣及其瓣下结构描绘在图1和图2中。
图3描绘了用于锚定人工心脏瓣膜或修复环到心脏的二尖瓣环的装置10。虽然其他材料(金属或非金属的)可以是合适的，但是装置10可以由金属，比如不锈钢制成。装置10由中心环12组成，该中心环12具有两个半圆形锚，即前锚14a和后锚14p，该两个半圆形锚在围绕环的周缘间隔开大约120度的角度16的位置处附接到中心环12并且从中心环12延伸。该角度和间距将装置10分成大约1/3和2/3部分，从而接近原生二尖瓣的前叶和后叶的比例。锚14a、14p被间隔稍微远离中心环12的外周缘并且基本上平行于中心环12的外周缘定位，并且分别限定前小叶接收槽18a和后小叶接收槽18p。小叶接收槽18a、18p具有大体上相当于二尖瓣的前叶和后叶的厚度的宽度20a、20p，即槽18a、18p具有约0.005至0.25英寸的宽度。这些槽宽度20a、20p足以允许二尖瓣的前叶和后叶滑动地进入槽18a、18p。槽18a、18p具有长度22a、22p，足以接收各自二尖瓣小叶的大部分。前叶接收槽18a的长度22a可以在约0.25至3.5英寸之间，而后叶接收槽18p的长度22p可以在约0.25和3.5英寸之间。中心环12限定具有内径26的内开口24。如果装置10是人工心脏瓣膜的一部分(例如，人工心脏瓣膜的支撑支架的一部分)，内径20可以在0.75至1.5英寸之间。如果装置10是瓣膜修复装置诸如瓣环成形环的一部分，内径可以在0.75至1.5英寸之间。
图4和图5描绘了锚定在二尖瓣环AN中的装置10。前叶AL被布置在前叶槽18a内，使得槽18a保持前叶AL的近端部分(小叶的近端部分邻近环AN，与邻近小叶边缘的远端部分相对)。类似地，后叶PL被布置在后叶槽18p内，使得槽18p接收后叶PL的近端部分(小叶的近端部分邻近环AN，与邻近小叶边缘的远端部分相对)。因此，前锚14a和后锚14p被布置在其各自的小叶AL、PL和心室壁之间，而中心环12被布置在二尖瓣环AN内。因此，锚14a、14p和槽18a、18p防止装置的移动，例如在心脏收缩过程中移动到心房中或者在心脏舒张过程中移动到心室中。小叶槽18a、18p用于夹紧小叶AL、PL，以锚定装置10在环AN中的期望位置。
图6A-6C示意性地描绘了装置10的安装，如从左心房观察的(即穿过二尖瓣向左心室中看)。在图6A中，布置装置10，中心环12大体上居中布置在二尖瓣环AN中，并且后锚自由端28p邻近AC连合处。将后锚自由端28p插在前叶和后叶之间(例如，通过整体地操纵装置10和/或通过弯曲后锚自由端28p远离邻近中心环12的其正常位置/从邻近中心环12的其正常位置向下)，这样其布置在后叶PL下面，并且然后逆时针方向旋转装置10，后叶PL滑入后锚槽18p中，到其中前锚自由端28a邻近PC连合处的点，如图6B中所示。然后，将前锚自由端28a插在前叶和后叶之间(例如，通过整体地操纵装置10和/或通过弯曲前锚自由端28a远离邻近中心环12的其正常位置/从邻近中心环12的其正常位置向下)，这样其布置在前叶AL下面，并且进一步顺时针方向旋转装置10，前叶AL滑入前锚槽18a中(并且后叶PL进一步滑入后锚槽18p中)，直到该装置完全就位。当完全就位时，如图6C中所描绘的，锚14a、14p均在其各自的小叶AL、PL以下，前叶锚14a的附接杆30a被布置在PC连合处，并且后叶锚14p的附接杆30p被布置在AC连合处。
图7A-7D描绘了利用本发明的锚定组件的人工二尖瓣组件40。瓣膜组件40具有固定到支撑结构44的三叶瓣膜部分42。支撑结构44包括锚定装置46，其自身具有带有后锚50a和前锚50p的中心环48，后锚50a和前锚50p限定后槽52a和前槽52p，后槽52a和前槽52p配置为滑动地接收二尖瓣的后叶和前叶。组件40进一步包括上游支架结构54，其配置为被膨胀到与周围组织接合，如与心房壁接合。该支架可以是自膨胀的或球囊膨胀的。支架54优选被卷曲(在球囊膨胀的情况下)或受限制的(在自膨胀的情况下)为相对小的输送直径用于输送，如图8A中所描绘的。一旦锚部分与原生瓣叶完全接合(即被旋转至接合)，支架可以被部署到其膨胀状态，如图8B中所描绘的。如果支架部分54是自膨胀的，输送导管将需要护套来限制支架为其压缩输送配置。如果支架是球囊膨胀的，输送导管将需要球囊或类似径向膨胀的装置，以径向膨胀支架。
各种元件的配置可以在组件上的不同位置处变化。例如，锚和/或中心环的横截面形状可以不同于矩形，和/或可以沿其长度改变。例如，如图9A和图9B中所描绘的，锚组件60可以具有中心环62，锚部分64a、64p具有“C”形的通道横截面。横截面形状可以被设计使得锚的平面内刚性基本上小于其平面外刚性，或者反之亦然。这种差异的刚性可以帮助锚在插入过程中贴合原生环，同时仍然提供轴向方向上的高保持力。
图10描绘了该装置的进一步实施方式，其中锚组件70具有后锚72p和前锚72a，但是锚72a、72p被固定至单独的组件环部分74a、74p。这些单独的环部分74a、74p可以相对于彼此旋转，从而允许锚72a、72p相对于彼此单独(独立)旋转。锚72a、72p的这种独立旋转可以使该装置的安装对于外科医生或其他使用者更容易。
可以作出各种修改以促进易用性。例如，锚装置80部分可以具有锚84a、84p，其具有圆端或其他的钝端，比如图11中所描绘的球形尖的端86a、86p，以便当小叶滑入槽88a、88p时降低尖端阻碍或损伤小叶组织、心室壁、索等的可能性。此类结构可以使锚84a、84p更容易在瓣膜小叶之后穿过。圆形结构可以与锚(即，同时，由相同材料形成等)形成为一体化部分，或者可以是在制造过程中附接到锚的单独部件。例如，圆形部分可以由压装和/或粘接到锚的PTFE形成。
根据本发明的锚定装置可以使用各种材料，并且可以包括覆盖物等。例如，锚定装置(例如由金属形成)的结构可以包括布覆盖物。这种覆盖物可以用于多种目的。例如，用促进组织向内生长的生物相容覆盖物，如PTFE布覆盖装置将促进患者的原生组织随时间附接到装置，可能地减少组织刺激和来自金属对组织接触的潜在损害。组织向内生长也可以帮助通过提供机械稳定性改进装置的锚定并且由此降低移动和栓塞的机会。该覆盖物，尤其是布覆盖物也可以为外科医生或其他使用者提供使用缝线来进一步固定装置在适当位置的能力。柔性/弹性覆盖物，如布也可以提供表面，该表面将“让路”(例如，被压缩)以允许小叶滑入槽中，但也将推回(即弹回)到槽中，以便一次接合小叶在适当位置并且帮助保持装置在适当位置。覆盖物也可以用于保持润滑涂层，如甘油，这可以促进锚在小叶和心室之间穿过。
如果存在，覆盖物可以配置为随时间生物再吸收(bioresorb)或以其他方式降解，或者可以由不会随时间生物降解/生物再吸收的材料(一种或多种)形成。潜在用于本发明的此类材料的示例包括PTFE、聚酯、尼龙和其他。
根据本发明的装置的结构支撑部分可以由金属或非金属形成，包括不锈钢、镍钛诺、钛、CoCr、合金、聚合材料和其他生物相容材料。结构支撑部分(即中心环和锚)可优选地由具有最小弹性的基本上刚性的并且不容易塑性变形的材料形成。根据本发明的装置可包括不透射线标记和其他结构，以在植入过程中增强可视性。例如，锚构件可具有一个或多个布置在其上的不透射线标记，如在自由端的尖端处和/或在固定端处。这样的不透射线标记可由高度不透射线材料(例如，金、铂)形成，该材料安装在装置的结构支撑件和/或其他部分上、嵌入装置的结构支撑件和/或其他部分中、与装置的结构支撑件和/或其他部分一起形成或者以其他方式固定到装置的结构支撑件和/或其他部分。
图12描绘了锚组件90的进一步实施方式，其中中心环92具有三个围绕装置的周长布置的锚94a、94b、94c。在所描绘的具体实施方式中，虽然其他间距在本发明的范围内，但是锚94a、94b、94c以约120度与彼此间隔。三锚设计可以适用于非二尖瓣位置处的部署，如在三尖瓣位置处(即在右心室和右心房之间的瓣膜和环)。可替代地，这种组件可以用于锚定在二尖瓣处，其中臂之一(例如，臂94a)用于固定到前叶，并且其他两个臂(例如，臂94a、94c)用于固定到后叶。为了适当地穿过装置到合适位置，外科医生或其他使用者可能需要在后叶中形成切口，比如在接近小叶/环接合处的连合点AC和PC之间的中间位置处，以便推进“额外的”臂(即，臂94c)在后叶下面。然后，后叶将具有两个锚，一个在AC连合处开始，一个在后叶的中间处(即，在所谓的“P2”部分中)开始。这样的配置可提供改进的部署和锚定能力。
本发明的进一步实施方式描绘在图13中，其中锚组件100具有中央部分102，锚104a、104p布置在中央部分102下面(例如，下游)。该配置提供对于给定原生瓣膜环尺寸在中央部分102上具有较大中心开口106的可能性，因此这可以容纳较大的人工瓣膜孔口(其中锚组件是人工瓣膜组件的一部分)或较大的原生瓣膜孔口(其中锚组件是修复装置，比如瓣环成形环的一部分)。
图14A和图14B描绘了锚组件110的进一步实施方式，其中锚112、112p以支架结构114的形式直接固定到中央部分。因此，支架结构114是代替如图3中所描绘的中心环部分的中央部分。图14B添加有与组件110一起形成或以其他方式附接到组件110的瓣膜支撑组件(即，连合支撑件116)。此类锚组件可用作人工瓣膜组件的一部分，如先前在图7A-7D中所描绘的。图14A-14B的实施方式具有额外的优势，即整个锚组件可以被径向地压缩，使得假体(例如，瓣环成形环和/或人工心脏瓣膜)可以被卷曲或以其他方式径向压缩为较小输送轮廓用于经由导管插入(例如，经皮/MIS)潜在输送到原生环并且部署在原生环处。如图14中所示的装置可以在经皮或微创式介入中或者经由心脏直视被输送通过导管。
虽然上面大体上描绘的实施方式具有基本上圆形的配置，这在一些应用——比如人工心脏瓣膜和瓣环成形环——中可以是优选的，但是本发明并不因此受限制。例如，也可以使用非圆形配置，如在图15中所描绘的大体D形配置。锚组件120具有基本上D形的中央部分122，锚124a、124p从其延伸并且弯曲以便配合中央部分122的基本D形状。这样的非圆形配置可以是特别有用的，其中锚组件120用作瓣环成形环或类似修复装置的一部分，如用于二尖瓣的瓣环成形环。注意根据本发明的锚组件——是否是圆形或非圆形，都不必是平面的。例如，三维形式，如在2004年10月19日授权的题为“Mitral ValveAnnuloplasty Ring for Molding Left Ventricle Geometry”的美国专利号6,805,710(其全部内容通过引用并入本文)中公开的所谓“3D鞍形状”也可以与本发明一起使用，以便形成贴合原生解剖结构或者使原生解剖结构变形/再成形的装置。
鉴于许多其中可以应用公开的发明的原则的可能的实施方式，应该认识到所阐述的实施方式仅是本发明的优选示例并且不应该视为限制本发明的范围。相反，本发明的范围由权利要求限定。

Claims (20)

1.一种设计用于在原生心脏瓣膜环处植入的装置的锚定装置，所述锚定装置包括：
中央部分，其具有一个或多个从其延伸的锚，所述一个或多个锚的每一个都具有固定到所述中央部分的近端固定端并且终止于自由端，所述一个或多个锚被间隔稍微远离以弯曲方式的所述中央部分的周缘并且基本上平行于以弯曲方式的所述中央部分的周缘定位，在所述锚和所述中央部分之间形成瓣膜小叶接收槽。
2.根据权利要求1所述的锚定装置，其中所述锚包括横截面，该横截面配置为具有与平面外刚性不同的平面内刚性。
3.根据权利要求1所述的锚定装置，其中所述锚大体上等距离地围绕所述锚定装置的所述中央部分的周缘布置。
4.根据权利要求1所述的锚定装置，其中所述锚由金属或聚合物形成。
5.根据权利要求1所述的锚定装置，其进一步包括一个或多个布置在其上的不透射线标记。
6.根据权利要求1所述的锚定装置，其中所述装置具有两个锚，并且所述锚的所述固定端被间隔开至少90度。
7.根据权利要求1所述的锚定装置，其中所述装置具有两个锚，并且所述锚的所述固定端被间隔开约120度。
8.根据权利要求1所述的锚定装置，其中所述装置具有两个锚，其中一个锚长于另一个锚。
9.根据权利要求1所述的锚定装置，其中所述装置具有三个锚。
10.根据权利要求1所述的锚定装置，其中所述槽具有约0.25至3.5英寸的长度。
11.根据权利要求1所述的锚定装置，其进一步包括布覆盖物。
12.根据权利要求1所述的锚定装置，其中所述中央部分基本上是圆形的。
13.根据权利要求1所述的锚定装置，其中所述中央部分是大体上D形的。
14.根据权利要求1所述的锚定装置，其进一步包括人工瓣膜，所述人工瓣膜包括支撑架和瓣膜部分，其中所述锚定装置被固定到所述人工瓣膜的所述支撑架。
15.根据权利要求14所述的锚定装置，其中所述人工瓣膜的至少一部分基本上是管状的并且具有形成连续弯曲表面的外表面，并且所述一个或多个锚形成曲线，所述曲线与所述人工瓣膜的外表面的弯曲表面平行。
16.根据权利要求1所述的锚定装置，其进一步包括瓣环成形环，其中所述锚定装置被固定到所述环，使得所述一个或多个锚至少部分地围绕所述环的周缘延伸并且基本上平行于所述环的外表面。
17.一种在原生瓣膜环处植入装置的方法，其包括：
提供包括中央部分、第一弯曲锚、第二弯曲锚的装置，所述第一弯曲锚从固定到所述中央部分的第一固定端延伸并且大体上平行于其外表面穿过到所述第一弯曲锚的第一自由端，以形成第一小叶接收槽，所述第二弯曲锚从固定到所述中央部分的第二固定端延伸并且大体上平行于其外表面穿过到第二自由端，以形成第二小叶接收槽，其中所述中央部分限定具有流体流动轴穿过其中的流动孔口；
用邻近所述原生瓣膜环的所述第一弯曲锚和第二弯曲锚布置所述装置，所述装置的流体流动轴大体上平行于穿过所述原生瓣膜环的流体流动路径，并且所述第一自由端邻近所述原生瓣膜环处的原有心脏瓣膜的第一连合处布置；
放置所述第一自由端在第一原有瓣膜小叶下面；
基本上绕其流体流动轴旋转所述装置，以推进所述第一自由端在所述第一原有瓣膜小叶下面并且由此滑动地推进所述第一原有瓣膜小叶进入所述第一小叶接收槽中；
监视所述第二自由端相对于所述原有心脏瓣膜的第二连合处的位置；
一旦所述第二自由端邻近所述原有心脏瓣膜的所述第二连合处，停止绕所述流体流动轴旋转所述装置；
放置所述第二自由端在第二原有瓣膜小叶下面；
重新开始基本上绕其流体流动轴旋转所述装置，以推进所述第二自由端在所述第二原有瓣膜小叶下面并且由此滑动地推进所述第二原有瓣膜小叶进入所述第二小叶接收槽中，同时也进一步推进所述第一自由端在所述第一原有瓣膜小叶下面并且进一步滑动地推进所述第一原有瓣膜小叶进入所述第一小叶接收槽中；以及
当所述第一原有瓣膜小叶在邻近所述第一固定端的位置处被滑动地推进到所述第一小叶接收槽中时，停止旋转所述装置，由此完成所述装置的部署。
18.根据权利要求17所述的方法，其中所述装置包括人工瓣膜，其中所述人工瓣膜包括支撑架和小叶，所述小叶固定到所述支撑架，以形成控制沿所述流动轴的流体流动的单向瓣膜结构。
19.根据权利要求17所述的方法，其中所述原有瓣膜环是原生二尖瓣环，所述第一连合处是原生二尖瓣的PC连合处，所述第一小叶是所述原生二尖瓣的前叶；所述第二连合处是所述原生二尖瓣的AC连合处，并且所述第二小叶是所述原生二尖瓣的后叶。
20.根据权利要求17所述的方法，其中所述装置包括瓣环成形环，所述中央部分形成所述瓣环成形环的环部分。
CN201280070351.9A 2011-12-21 2012-11-15 用于置换或修复心脏瓣膜的锚定装置 Active CN104125817B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161578758P 2011-12-21 2011-12-21
US61/578,758 2011-12-21
US13/675,801 2012-11-13
US13/675,801 US9078747B2 (en) 2011-12-21 2012-11-13 Anchoring device for replacing or repairing a heart valve
PCT/US2012/065312 WO2013095816A1 (en) 2011-12-21 2012-11-15 Anchoring device and method for replacing or repairing a heart valve

Publications (2)

Publication Number Publication Date
CN104125817A true CN104125817A (zh) 2014-10-29
CN104125817B CN104125817B (zh) 2017-03-22

Family

ID=48655329

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280070351.9A Active CN104125817B (zh) 2011-12-21 2012-11-15 用于置换或修复心脏瓣膜的锚定装置

Country Status (5)

Country Link
US (5) US9078747B2 (zh)
EP (1) EP2793752B1 (zh)
CN (1) CN104125817B (zh)
CA (1) CA2859666C (zh)
WO (1) WO2013095816A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472142A (zh) * 2015-11-17 2018-08-31 爱德华兹生命科学公司 用于设置锚定器的系统和装置
CN112754732A (zh) * 2021-01-20 2021-05-07 上海纽脉医疗科技有限公司 一种介入式人工心脏瓣膜及医用装置

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE530568C2 (sv) * 2006-11-13 2008-07-08 Medtentia Ab Anordning och metod för förbättring av funktionen hos en hjärtklaff
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2010117680A1 (en) 2009-03-30 2010-10-14 Cardiovantage Medical, Inc. Sutureless valve prostheses and devices and methods for delivery
WO2011072084A2 (en) 2009-12-08 2011-06-16 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US9307980B2 (en) * 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US9241702B2 (en) * 2010-01-22 2016-01-26 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
WO2011109813A2 (en) 2010-03-05 2011-09-09 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
WO2011111047A2 (en) 2010-03-10 2011-09-15 Mitraltech Ltd. Prosthetic mitral valve with tissue anchors
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US8657872B2 (en) 2010-07-19 2014-02-25 Jacques Seguin Cardiac valve repair system and methods of use
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2012012761A2 (en) 2010-07-23 2012-01-26 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9005279B2 (en) * 2010-11-12 2015-04-14 Shlomo Gabbay Beating heart buttress and implantation method to prevent prolapse of a heart valve
EP2688516B1 (en) 2011-03-21 2022-08-17 Cephea Valve Technologies, Inc. Disk-based valve apparatus
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP4289398A3 (en) * 2011-08-11 2024-03-13 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US9387075B2 (en) * 2011-09-12 2016-07-12 Highlife Sas Transcatheter valve prosthesis
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
JP6049761B2 (ja) 2012-01-31 2016-12-21 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 僧帽弁ドッキングデバイス、システム、および方法
US9180008B2 (en) 2012-02-29 2015-11-10 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
US9839519B2 (en) 2012-02-29 2017-12-12 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
WO2013175468A2 (en) 2012-05-20 2013-11-28 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US8961594B2 (en) 2012-05-31 2015-02-24 4Tech Inc. Heart valve repair system
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US8628571B1 (en) 2012-11-13 2014-01-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
EP2943132B1 (en) 2013-01-09 2018-03-28 4Tech Inc. Soft tissue anchors
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
CA2905422A1 (en) 2013-03-14 2014-10-02 Cardiovantage Medical, Inc. Embolic protection devices and methods of use
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
WO2014141239A1 (en) 2013-03-14 2014-09-18 4Tech Inc. Stent with tether interface
EP3804646A1 (en) 2013-03-15 2021-04-14 Valcare, Inc. Systems for delivery of annuloplasty rings
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US11224510B2 (en) 2013-04-02 2022-01-18 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US20160089235A1 (en) * 2013-05-22 2016-03-31 Valcare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
US10813751B2 (en) 2013-05-22 2020-10-27 Valcare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
US20160120642A1 (en) 2013-05-24 2016-05-05 Valcare, Inc. Heart and peripheral vascular valve replacement in conjunction with a support ring
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
AU2014282817B2 (en) * 2013-06-17 2018-08-16 Alan HELDMAN Prosthetic heart valve with linking element and methods for implanting same
JP6461122B2 (ja) 2013-06-25 2019-01-30 テンダイン ホールディングス，インコーポレイテッド 人工心臓弁の血栓管理及び構造コンプライアンス特徴
EP3013253B1 (en) 2013-06-28 2021-01-06 ValCare, Inc. Device for securing an article to a tissue
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
EP3027144B1 (en) 2013-08-01 2017-11-08 Tendyne Holdings, Inc. Epicardial anchor devices
SG10202103500PA (en) 2013-08-12 2021-05-28 Mitral Valve Tech Sarl Apparatus and methods for implanting a replacement heart valve
US10052198B2 (en) 2013-08-14 2018-08-21 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
JP6328242B2 (ja) 2013-08-14 2018-05-23 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 心臓弁置換のためのシステム
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
WO2015058039A1 (en) 2013-10-17 2015-04-23 Robert Vidlund Apparatus and methods for alignment and deployment of intracardiac devices
CN108635083B (zh) * 2013-10-25 2021-04-20 科法利欧斯有限公司 可调节的瓣环成形术环圈及系统
EP3656353A1 (en) 2013-10-28 2020-05-27 Tendyne Holdings, Inc. Prosthetic heart valve and systems for delivering the same
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US10039643B2 (en) 2013-10-30 2018-08-07 4Tech Inc. Multiple anchoring-point tension system
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
PL3102152T3 (pl) 2014-02-04 2020-02-28 Innovheart S.R.L. Urządzenie protetyczne dla zastawki serca
WO2015120122A2 (en) 2014-02-05 2015-08-13 Robert Vidlund Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
EP3107498B1 (en) 2014-02-21 2020-09-30 Mitral Valve Technologies Sàrl Prosthetic mitral valve with anchoring device
AU2015229708B2 (en) 2014-03-10 2019-08-15 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
CN106573129B (zh) 2014-06-19 2019-09-24 4科技有限公司 心脏组织束紧
US10195026B2 (en) * 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
EP4066786A1 (en) 2014-07-30 2022-10-05 Cardiovalve Ltd. Articulatable prosthetic valve
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US9907547B2 (en) 2014-12-02 2018-03-06 4Tech Inc. Off-center tissue anchors
US9439757B2 (en) 2014-12-09 2016-09-13 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
EP3242630A2 (en) 2015-01-07 2017-11-15 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
EP3253333B1 (en) 2015-02-05 2024-04-03 Cardiovalve Ltd Prosthetic valve with axially-sliding frames
CA2975294A1 (en) 2015-02-05 2016-08-11 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US10231827B2 (en) 2015-03-18 2019-03-19 Medtronic Vascular, Inc. Valve prostheses having an integral centering mechanism and methods of use thereof
CA2983002C (en) 2015-04-16 2023-07-04 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
EP3294220B1 (en) 2015-05-14 2023-12-06 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
WO2016183526A1 (en) * 2015-05-14 2016-11-17 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2017004369A1 (en) * 2015-07-02 2017-01-05 Edwards Lifesciences Corporation Hybrid heart valves adapted for post-implant expansion
US10034747B2 (en) 2015-08-27 2018-07-31 Medtronic Vascular, Inc. Prosthetic valve system having a docking component and a prosthetic valve component
US10080653B2 (en) * 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
CN111329541B (zh) * 2015-11-17 2023-09-19 波士顿科学国际有限公司 用于使心脏瓣环重新定形的可植入装置和输送系统
ES2777609T3 (es) 2015-12-03 2020-08-05 Tendyne Holdings Inc Características del marco para válvulas mitrales protésicas
CN108366859B (zh) 2015-12-28 2021-02-05 坦迪尼控股股份有限公司 用于假体心脏瓣膜的心房囊袋闭合件
US11833034B2 (en) 2016-01-13 2023-12-05 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US10433952B2 (en) 2016-01-29 2019-10-08 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
EP3468480B1 (en) 2016-06-13 2023-01-11 Tendyne Holdings, Inc. Sequential delivery of two-part prosthetic mitral valve
US11331187B2 (en) 2016-06-17 2022-05-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US10588745B2 (en) 2016-06-20 2020-03-17 Medtronic Vascular, Inc. Modular valve prosthesis, delivery system, and method of delivering and deploying a modular valve prosthesis
WO2018005779A1 (en) 2016-06-30 2018-01-04 Tegels Zachary J Prosthetic heart valves and apparatus and methods for delivery of same
US10828150B2 (en) 2016-07-08 2020-11-10 Edwards Lifesciences Corporation Docking station for heart valve prosthesis
US11065116B2 (en) 2016-07-12 2021-07-20 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
CN114587712A (zh) 2016-08-10 2022-06-07 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
CN107753153B (zh) 2016-08-15 2022-05-31 沃卡尔有限公司 用于治疗心脏瓣膜关闭不全的装置和方法
US10722359B2 (en) 2016-08-26 2020-07-28 Edwards Lifesciences Corporation Heart valve docking devices and systems
CR20190069A (es) 2016-08-26 2019-05-14 Edwards Lifesciences Corp Valvulas y sistemas de acoplamiento de valvulas corazon
US10357361B2 (en) 2016-09-15 2019-07-23 Edwards Lifesciences Corporation Heart valve pinch devices and delivery systems
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
HUE061376T2 (hu) 2016-12-16 2023-06-28 Edwards Lifesciences Corp Behelyezõ rendszerek és mûszerek rögzítõeszköz bejuttatására egy billentyûprotézishez
EP3906893A1 (en) 2016-12-20 2021-11-10 Edwards Lifesciences Corporation Systems and mechanisms for deploying a docking device for a replacement heart valve
US10813749B2 (en) 2016-12-20 2020-10-27 Edwards Lifesciences Corporation Docking device made with 3D woven fabric
US11654023B2 (en) 2017-01-23 2023-05-23 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11013600B2 (en) 2017-01-23 2021-05-25 Edwards Lifesciences Corporation Covered prosthetic heart valve
CR20190381A (es) 2017-01-23 2019-09-27 Cephea Valve Tech Inc Valvulas mitrales de reemplazo
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
AU2018203053B2 (en) 2017-01-23 2020-03-05 Cephea Valve Technologies, Inc. Replacement mitral valves
US10561495B2 (en) 2017-01-24 2020-02-18 4C Medical Technologies, Inc. Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve
USD867595S1 (en) 2017-02-01 2019-11-19 Edwards Lifesciences Corporation Stent
CN108618871A (zh) 2017-03-17 2018-10-09 沃卡尔有限公司 具有多方向锚部的二尖瓣或三尖瓣修复系统
CN110678149B (zh) 2017-03-27 2021-12-21 楚利福医疗有限公司 包括对接元件的用于治疗病变二尖瓣的设备
US10842619B2 (en) 2017-05-12 2020-11-24 Edwards Lifesciences Corporation Prosthetic heart valve docking assembly
CN110891526A (zh) 2017-06-30 2020-03-17 爱德华兹生命科学公司 用于经导管植入式设备的锁定和释放机构
CA3068313A1 (en) 2017-06-30 2019-01-03 Edwards Lifesciences Corporation Docking stations for transcatheter valves
WO2019014473A1 (en) 2017-07-13 2019-01-17 Tendyne Holdings, Inc. PROSTHETIC CARDIAC VALVES AND ASSOCIATED APPARATUS AND METHODS FOR IMPLEMENTING THE SAME
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
USD890333S1 (en) 2017-08-21 2020-07-14 Edwards Lifesciences Corporation Heart valve docking coil
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
JP7291124B2 (ja) 2017-08-28 2023-06-14 テンダイン ホールディングス，インコーポレイテッド テザー連結部を有する人工心臓弁
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
CA3081357A1 (en) 2018-01-07 2019-07-11 Suzhou Jiecheng Medical Technology Co., Ltd. Prosthetic heart valve delivery system
CN117796968A (zh) 2018-01-07 2024-04-02 苏州杰成医疗科技有限公司 瓣膜假体
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
US11517435B2 (en) * 2018-05-04 2022-12-06 Edwards Lifesciences Corporation Ring-based prosthetic cardiac valve
US20200069426A1 (en) * 2018-08-28 2020-03-05 Edwards Lifesciences Corporation Methods and devices for ventricular reshaping and heart valve reshaping
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
US11395738B2 (en) 2018-09-25 2022-07-26 Truleaf Medical Ltd. Docking elements
CA3115270A1 (en) 2018-10-05 2020-04-09 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
CA3118599A1 (en) 2018-11-08 2020-05-14 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
WO2020117842A1 (en) 2018-12-03 2020-06-11 Valcare, Inc. Stabilizing and adjusting tool for controlling a minimally invasive mitral / tricuspid valve repair system
EP3941391A4 (en) 2019-03-19 2022-11-23 Shifamed Holdings, LLC HEART VALVE PROSTHESIS, SYSTEMS AND PROCEDURES
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
WO2021011702A1 (en) 2019-07-15 2021-01-21 Valcare, Inc. Transcatheter bio-prosthesis member and support structure
EP3831343B1 (en) 2019-12-05 2024-01-31 Tendyne Holdings, Inc. Braided anchor for mitral valve
US11382741B2 (en) * 2019-12-18 2022-07-12 St. Jude Medical, Cardiology Division, Inc. Devices and methods for surgical valve expansion
US11648114B2 (en) 2019-12-20 2023-05-16 Tendyne Holdings, Inc. Distally loaded sheath and loading funnel
US11931253B2 (en) 2020-01-31 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
US11951002B2 (en) 2020-03-30 2024-04-09 Tendyne Holdings, Inc. Apparatus and methods for valve and tether fixation
US11707355B2 (en) 2020-05-28 2023-07-25 Medtronic, Inc. Modular heart valve prosthesis
WO2022039853A1 (en) 2020-08-19 2022-02-24 Tendyne Holdings, Inc. Fully-transseptal apical pad with pulley for tensioning
CA3221422A1 (en) * 2021-06-17 2022-12-22 Sheba Impact Ltd. Valve frame for prosthetic tricuspid valve

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127982A1 (en) * 2002-10-01 2004-07-01 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US20050203617A1 (en) * 2004-02-27 2005-09-15 Cardiacmd, Inc. Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
CN1714766A (zh) * 2000-07-06 2006-01-04 梅德坦蒂亚公司 瓣环成形设备
US7377941B2 (en) * 2004-06-29 2008-05-27 Micardia Corporation Adjustable cardiac valve implant with selective dimensional adjustment
US20090043381A1 (en) * 2004-10-05 2009-02-12 Macoviak John A Atrioventricular valve annulus repair systems and methods including retro-chordal anchors
CN101588771A (zh) * 2006-11-13 2009-11-25 梅德坦蒂亚公司 用于改善心脏瓣膜功能的装置和方法
US20100204785A1 (en) * 2007-09-28 2010-08-12 Alkhatib Yousef F Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
CN103517688A (zh) * 2011-01-11 2014-01-15 汉斯·赖纳·菲古拉 用来替代心脏房室瓣的瓣膜假体

Family Cites Families (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3143742A (en) 1963-03-19 1964-08-11 Surgitool Inc Prosthetic sutureless heart valve
US3320972A (en) 1964-04-16 1967-05-23 Roy F High Prosthetic tricuspid valve and method of and device for fabricating same
US3371352A (en) 1965-01-19 1968-03-05 Edwards Lab Inc Heart valve for quick implantation having provision for ingrowth of tissue
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
GB1172990A (en) 1965-12-11 1969-12-03 Valery Ivanovich Shumakov Cardiac Valve Prosthesis and Instrument for Mounting and Fixing it in Position
GB1180396A (en) 1966-08-08 1970-02-04 Lucas Industries Ltd Dynamo Electric Machines
US3574865A (en) 1968-08-08 1971-04-13 Michigan Instr Inc Prosthetic sutureless heart valve
USRE30912E (en) 1968-09-16 1982-04-27 Hancock Laboratories, Inc. Stent for heart valve
US3628535A (en) 1969-11-12 1971-12-21 Nibot Corp Surgical instrument for implanting a prosthetic heart valve or the like
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3686740A (en) 1970-06-19 1972-08-29 Donald P Shiley Method of assemblying a sutureless heart valve
US3755823A (en) 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US3839741A (en) 1972-11-17 1974-10-08 J Haller Heart valve and retaining means therefor
FR2306671A1 (fr) 1975-04-11 1976-11-05 Rhone Poulenc Ind Implant valvulaire
US3997923A (en) 1975-04-28 1976-12-21 St. Jude Medical, Inc. Heart valve prosthesis and suturing assembly and method of implanting a heart valve prosthesis in a heart
US4340091A (en) 1975-05-07 1982-07-20 Albany International Corp. Elastomeric sheet materials for heart valve and other prosthetic implants
FR2298313A1 (fr) 1975-06-23 1976-08-20 Usifroid Reducteur lineaire pour valvuloplastie
US4035849A (en) 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
AR206762A1 (es) 1976-01-01 1976-08-13 Pisanu A Bioprotesis de bajo perfil derivada de la valvula aortica heterologa de porcino
CA1069652A (en) 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4084268A (en) 1976-04-22 1978-04-18 Shiley Laboratories, Incorporated Prosthetic tissue heart valve
US4078468A (en) 1976-10-21 1978-03-14 Simon Civitello Apparatus for extending a lower range of a stringed musical instrument
DK229077A (da) 1977-05-25 1978-11-26 Biocoating Aps Hjerteklapprotese samt fremgangsmaade til fremstilling heraf
US4172295A (en) 1978-01-27 1979-10-30 Shiley Scientific, Inc. Tri-cuspid three-tissue prosthetic heart valve
AR221872A1 (es) 1979-03-16 1981-03-31 Liotta Domingo S Mejoras en valvulas cardiacas impantables
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4388735A (en) 1980-11-03 1983-06-21 Shiley Inc. Low profile prosthetic xenograft heart valve
EP0125393B1 (en) 1980-11-03 1987-12-09 Shiley Incorporated Prosthetic heart valve
US4470157A (en) 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4364126A (en) 1981-07-28 1982-12-21 Vascor, Inc. Heart valve with removable cusp protector band
US4501030A (en) 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4865600A (en) 1981-08-25 1989-09-12 Baxter International Inc. Mitral valve holder
US4451936A (en) 1981-12-21 1984-06-05 American Hospital Supply Corporation Supra-annular aortic valve
EP0084395B1 (en) 1982-01-20 1986-08-13 Martin Morris Black Artificial heart valves
US4680031A (en) 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
SU1116573A1 (ru) 1983-01-07 1985-07-15 Предприятие П/Я А-1619 Биопротез сердечного клапана
GB8300636D0 (en) 1983-01-11 1983-02-09 Black M M Heart valve replacements
US4506394A (en) 1983-01-13 1985-03-26 Molrose Management, Ltd. Cardiac valve prosthesis holder
US4535483A (en) 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
AR229309A1 (es) 1983-04-20 1983-07-15 Barone Hector Daniel Montura para valvulas cardiacas
IL74460A (en) 1983-09-02 1990-01-18 Istec Ind & Technologies Ltd Surgical implement particularly useful for suturing prosthetic valves
US4626255A (en) 1983-09-23 1986-12-02 Christian Weinhold Heart valve bioprothesis
DE8327414U1 (de) 1983-09-23 1984-02-02 Reichart, Bruno, Prof. Dr. Herzklappenprothese
US4629459A (en) 1983-12-28 1986-12-16 Shiley Inc. Alternate stent covering for tissue valves
GB8424582D0 (en) 1984-09-28 1984-11-07 Univ Glasgow Heart valve prosthesis
NL8500538A (nl) 1985-02-26 1986-09-16 Stichting Tech Wetenschapp Hartklepprothese, werkwijze voor het vervaardigen van een hartklepprothese en daarbij toegepaste mal.
US4888009A (en) 1985-04-05 1989-12-19 Abiomed, Inc. Prosthetic heart valve
DE3541478A1 (de) 1985-11-23 1987-05-27 Beiersdorf Ag Herzklappenprothese und verfahren zu deren herstellung
US4790843A (en) 1986-06-16 1988-12-13 Baxter Travenol Laboratories, Inc. Prosthetic heart valve assembly
US4725274A (en) 1986-10-24 1988-02-16 Baxter Travenol Laboratories, Inc. Prosthetic heart valve
US4914097A (en) 1987-02-25 1990-04-03 Mitsubishi Kasei Corporation N-indanyl carboxamide derivative and agricultural/horticultural fungicide containing the derivative as active ingredient
SU1697790A1 (ru) 1987-03-02 1991-12-15 Сибирский физико-технический институт им.В.Д.Кузнецова при Томском государственном университете им.В.В.Куйбышева Протез клапана сердца с механической фиксацией
US4851000A (en) 1987-07-31 1989-07-25 Pacific Biomedical Holdings, Ltd. Bioprosthetic valve stent
US5010892A (en) 1988-05-04 1991-04-30 Triangle Research And Development Corp. Body lumen measuring instrument
US4960424A (en) 1988-06-30 1990-10-02 Grooters Ronald K Method of replacing a defective atrio-ventricular valve with a total atrio-ventricular valve bioprosthesis
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US5041130A (en) 1989-07-31 1991-08-20 Baxter International Inc. Flexible annuloplasty ring and holder
US5290300A (en) 1989-07-31 1994-03-01 Baxter International Inc. Flexible suture guide and holder
US5697375A (en) 1989-09-18 1997-12-16 The Research Foundation Of State University Of New York Method and apparatus utilizing heart sounds for determining pressures associated with the left atrium
US4993428A (en) 1990-02-12 1991-02-19 Microstrain Company Method of and means for implanting a pressure and force sensing apparatus
US5147391A (en) 1990-04-11 1992-09-15 Carbomedics, Inc. Bioprosthetic heart valve with semi-permeable commissure posts and deformable leaflets
US5037434A (en) 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5059177A (en) 1990-04-19 1991-10-22 Cordis Corporation Triple lumen balloon catheter
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (da) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
US5489298A (en) 1991-01-24 1996-02-06 Autogenics Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure
US5163955A (en) 1991-01-24 1992-11-17 Autogenics Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment
US5755782A (en) 1991-01-24 1998-05-26 Autogenics Stents for autologous tissue heart valve
ES2028611A6 (es) 1991-02-07 1992-07-01 Garcia Gonzalez Moro Jose Beni Valvula cardiaca artificial.
JPH05184611A (ja) 1991-03-19 1993-07-27 Kenji Kusuhara 弁輪支持器具及びその取り付け方法
PL167854B1 (en) 1991-05-08 1995-11-30 Nika Health Products Ltd Method of covering valvule prosthesis base with textile material and apparatus therefor
EP0583341B1 (en) 1991-05-08 1996-04-17 Nika Health Products Limited Support for a heart valve prosthesis
US5397351A (en) 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5584803A (en) 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5571215A (en) 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5704361A (en) 1991-11-08 1998-01-06 Mayo Foundation For Medical Education And Research Volumetric image ultrasound transducer underfluid catheter system
US5258021A (en) 1992-01-27 1993-11-02 Duran Carlos G Sigmoid valve annuloplasty ring
US5489297A (en) 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5258023A (en) 1992-02-12 1993-11-02 Reger Medical Development, Inc. Prosthetic heart valve
GB9206449D0 (en) 1992-03-25 1992-05-06 Univ Leeds Artificial heart valve
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5316016A (en) 1992-07-07 1994-05-31 Scimed Life Systems, Inc. Imaging balloon catheter and methods for use and manufacture
DE4222610A1 (de) 1992-07-10 1994-01-13 Jansen Josef Dr Ing Stützgehäuse für Klappen- und Schließorgane
US5314582A (en) 1992-07-22 1994-05-24 Chicopee Cellulosic fiber of improved wettability
US5449384A (en) 1992-09-28 1995-09-12 Medtronic, Inc. Dynamic annulus heart valve employing preserved porcine valve leaflets
US5336178A (en) 1992-11-02 1994-08-09 Localmed, Inc. Intravascular catheter with infusion array
US6283127B1 (en) 1992-12-03 2001-09-04 Wesley D. Sterman Devices and methods for intracardiac procedures
US5814097A (en) 1992-12-03 1998-09-29 Heartport, Inc. Devices and methods for intracardiac procedures
US5522884A (en) 1993-02-19 1996-06-04 Medtronic, Inc. Holder for adjustable mitral & tricuspid annuloplasty rings
US5682906A (en) 1993-02-22 1997-11-04 Heartport, Inc. Methods of performing intracardiac procedures on an arrested heart
US6010531A (en) 1993-02-22 2000-01-04 Heartport, Inc. Less-invasive devices and methods for cardiac valve surgery
US5431676A (en) 1993-03-05 1995-07-11 Innerdyne Medical, Inc. Trocar system having expandable port
GB9312666D0 (en) 1993-06-18 1993-08-04 Vesely Ivan Bioprostetic heart valve
US5411522A (en) 1993-08-25 1995-05-02 Linvatec Corporation Unitary anchor for soft tissue fixation
US5396887A (en) 1993-09-23 1995-03-14 Cardiac Pathways Corporation Apparatus and method for detecting contact pressure
US5713950A (en) 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
US5425741A (en) 1993-12-17 1995-06-20 Autogenics Tissue cutting die
DE69431122T2 (de) 1993-12-22 2003-03-27 St Jude Medical Herzklappenhalter
US5476510A (en) 1994-04-21 1995-12-19 Medtronic, Inc. Holder for heart valve
DE69523251T2 (de) 1994-04-22 2002-07-25 Medtronic Inc Gestützte herzklappenprothese
GB9408314D0 (en) 1994-04-27 1994-06-15 Cardio Carbon Co Ltd Heart valve prosthesis
US5531785A (en) 1994-05-06 1996-07-02 Autogenics, Inc. Prosthetic heart valve holder
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5573007A (en) 1994-08-08 1996-11-12 Innerspace, Inc. Gas column pressure monitoring catheters
US5533515A (en) 1994-08-11 1996-07-09 Foster-Miller Solid state sphincter myometers
US5545133A (en) 1994-09-16 1996-08-13 Scimed Life Systems, Inc. Balloon catheter with improved pressure source
US5562729A (en) 1994-11-01 1996-10-08 Biocontrol Technology, Inc. Heart valve
US5776187A (en) 1995-02-09 1998-07-07 St. Jude Medical, Inc. Combined holder tool and rotator for a prosthetic heart valve
US5626607A (en) 1995-04-03 1997-05-06 Heartport, Inc. Clamp assembly and method of use
US5618307A (en) 1995-04-03 1997-04-08 Heartport, Inc. Clamp assembly and method of use
US5752522A (en) 1995-05-04 1998-05-19 Cardiovascular Concepts, Inc. Lesion diameter measurement catheter and method
US5824064A (en) 1995-05-05 1998-10-20 Taheri; Syde A. Technique for aortic valve replacement with simultaneous aortic arch graft insertion and apparatus therefor
US5578076A (en) 1995-05-24 1996-11-26 St. Jude Medical, Inc. Low profile holder for heart valve prosthesis
US5728152A (en) 1995-06-07 1998-03-17 St. Jude Medical, Inc. Bioresorbable heart valve support
US5716417A (en) 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
ZA964885B (en) 1995-06-07 1997-02-06 St Jude Medical Direct suture orifice for mechanical heart valve.
AU6029696A (en) 1995-06-07 1996-12-30 St. Jude Medical Inc. Adjustable sizing apparatus for heart annulus
US5865801A (en) 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
DE19532846A1 (de) 1995-09-06 1997-03-13 Georg Dr Berg Ventileinrichtung
US5713952A (en) 1995-09-11 1998-02-03 St. Jude Medical, Inc. Apparatus for attachment of heart valve holder to heart valve prosthesis
US5628789A (en) 1995-09-11 1997-05-13 St. Jude Medical, Inc. Apparatus for attachment of heart valve holder to heart valve prosthesis
US5695503A (en) 1995-09-14 1997-12-09 St. Jude Medical, Inc. Apparatus for attachment of heart valve holder to heart valve prosthesis
GB9519194D0 (en) 1995-09-20 1995-11-22 Univ Wales Medicine Anorectal angle measurement
US6162233A (en) 1996-02-23 2000-12-19 Cardiovascular Technologies, Llc Wire fasteners for use in minimally invasive surgery and means and methods for handling those fasteners
US5716370A (en) 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US5891160A (en) 1996-02-23 1999-04-06 Cardiovascular Technologies, Llc Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery
US5972004A (en) 1996-02-23 1999-10-26 Cardiovascular Technologies, Llc. Wire fasteners for use in minimally invasive surgery and apparatus and methods for handling those fasteners
US6402780B2 (en) 1996-02-23 2002-06-11 Cardiovascular Technologies, L.L.C. Means and method of replacing a heart valve in a minimally invasive manner
US20020068949A1 (en) 1996-02-23 2002-06-06 Williamson Warren P. Extremely long wire fasteners for use in minimally invasive surgery and means and method for handling those fasteners
US5885228A (en) 1996-05-08 1999-03-23 Heartport, Inc. Valve sizer and method of use
WO1997042871A1 (en) 1996-05-10 1997-11-20 Cardiovascular Concepts, Inc. Lesion diameter measurement catheter and method
SE506299C2 (sv) 1996-05-20 1997-12-01 Bertil Oredsson Givare för att detektera ändringar i tvärsnitt hos en långsträckt kroppshålighet
US5855601A (en) 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
GB9614950D0 (en) 1996-07-16 1996-09-04 Anson Medical Ltd A ductus stent and delivery catheter
DE19632263C1 (de) 1996-08-09 1998-01-08 Domed Medizintechnik Gmbh Verfahren und Vorrichtung zur venösen Kompressionsplethysmographie
US5848969A (en) 1996-10-28 1998-12-15 Ep Technologies, Inc. Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5766240A (en) 1996-10-28 1998-06-16 Medtronic, Inc. Rotatable suturing ring for prosthetic heart valve
US5919147A (en) 1996-11-01 1999-07-06 Jain; Krishna M. Method and apparatus for measuring the vascular diameter of a vessel
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US5924984A (en) 1997-01-30 1999-07-20 University Of Iowa Research Foundation Anorectal probe apparatus having at least one muscular activity sensor
US5908450A (en) 1997-02-28 1999-06-01 Medtronic, Inc. Physiologic mitral valve implantation holding system
US5928281A (en) 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves
US5833605A (en) 1997-03-28 1998-11-10 Shah; Ajit Apparatus for vascular mapping and methods of use
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
AU9225598A (en) 1997-09-04 1999-03-22 Endocore, Inc. Artificial chordae replacement
US5984959A (en) 1997-09-19 1999-11-16 United States Surgical Heart valve replacement tools and procedures
US5921934A (en) 1997-11-25 1999-07-13 Scimed Life Systems, Inc. Methods and apparatus for non-uniform rotation distortion detection in an intravascular ultrasound imaging system
US6254642B1 (en) 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
EP1049425B1 (en) 1997-12-29 2009-11-25 Cleveland Clinic Foundation The System for minimally invasive insertion of a bioprosthetic heart valve
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
FR2776912B1 (fr) 1998-04-06 2000-08-04 Houari Lofti DISPOSITIF D'EXPLOITATION PER OPERATOIRE DE l'APPAREIL CARDIO-CIRCULATOIRE DU CORPS HUMAIN OU ANIMAL
US6074418A (en) 1998-04-20 2000-06-13 St. Jude Medical, Inc. Driver tool for heart valve prosthesis fasteners
US6176877B1 (en) 1998-04-20 2001-01-23 St. Jude Medical, Inc. Two piece prosthetic heart valve
US6059827A (en) 1998-05-04 2000-05-09 Axya Medical, Inc. Sutureless cardiac valve prosthesis, and devices and methods for implanting them
US6106550A (en) 1998-07-10 2000-08-22 Sulzer Carbomedics Inc. Implantable attaching ring
US6527979B2 (en) 1999-08-27 2003-03-04 Corazon Technologies, Inc. Catheter systems and methods for their use in the treatment of calcified vascular occlusions
US6197054B1 (en) 1998-09-01 2001-03-06 Sulzer Carbomedics Inc. Sutureless cuff for heart valves
US6334873B1 (en) 1998-09-28 2002-01-01 Autogenics Heart valve having tissue retention with anchors and an outer sheath
US6371963B1 (en) 1998-11-17 2002-04-16 Scimed Life Systems, Inc. Device for controlled endoscopic penetration of injection needle
US6066160A (en) 1998-11-23 2000-05-23 Quickie Llc Passive knotless suture terminator for use in minimally invasive surgery and to facilitate standard tissue securing
US6264611B1 (en) 1998-11-25 2001-07-24 Ball Semiconductor, Inc. Monitor for interventional procedures
US6126007A (en) 1998-12-30 2000-10-03 St. Jude Medical, Inc. Tissue valve holder
CN2356656Y (zh) 1999-01-11 2000-01-05 北京思达医用装置有限公司 双叶式人工心脏瓣膜
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
DE19907646A1 (de) 1999-02-23 2000-08-24 Georg Berg Ventileinrichtung zum Einsetzen in ein Hohlorgan
CA2620783C (en) 1999-04-09 2011-04-05 Evalve, Inc. Methods and apparatus for cardiac valve repair
WO2000064380A1 (en) 1999-04-23 2000-11-02 St. Jude Medical Cardiovascular Group, Inc. Artificial heart valve attachment apparatus
US7147663B1 (en) 1999-04-23 2006-12-12 St. Jude Medical Atg, Inc. Artificial heart valve attachment apparatus and methods
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
US6217611B1 (en) 1999-05-26 2001-04-17 Sulzer Carbomedics Inc. Modular heart valve prothesis
US6287339B1 (en) 1999-05-27 2001-09-11 Sulzer Carbomedics Inc. Sutureless heart valve prosthesis
US6241765B1 (en) 1999-07-15 2001-06-05 Sulzer Carbomedics Inc. Stapled heart prosthesis and method of installing same
US6312465B1 (en) 1999-07-23 2001-11-06 Sulzer Carbomedics Inc. Heart valve prosthesis with a resiliently deformable retaining member
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
DE19945587A1 (de) 1999-09-23 2001-05-10 Co Don Ag Verfahren zum Einsetzen von Implantaten in menschliche Organe
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US20070043435A1 (en) 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US20010041914A1 (en) 1999-11-22 2001-11-15 Frazier Andrew G.C. Tissue patch deployment catheter
NZ520462A (en) 2000-01-27 2004-08-27 3F Therapeutics Inc Prosthetic heart valve
PL211860B1 (pl) 2000-01-31 2012-07-31 Cook Biotech Inc Zespół zastawki stentu
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US20050070999A1 (en) 2000-02-02 2005-03-31 Spence Paul A. Heart valve repair apparatus and methods
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US6468305B1 (en) 2000-05-16 2002-10-22 St. Jude Medical, Inc. Two piece valve
US6805711B2 (en) 2000-06-02 2004-10-19 3F Therapeutics, Inc. Expandable medical implant and percutaneous delivery
US20050043757A1 (en) 2000-06-12 2005-02-24 Michael Arad Medical devices formed from shape memory alloys displaying a stress-retained martensitic state and method for use thereof
US7077861B2 (en) 2000-07-06 2006-07-18 Medtentia Ab Annuloplasty instrument
AU2001287144A1 (en) 2000-09-07 2002-03-22 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
WO2002022054A1 (en) 2000-09-12 2002-03-21 Gabbay S Valvular prosthesis and method of using same
US7510572B2 (en) 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6893459B1 (en) 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
ES2253325T3 (es) 2000-12-15 2006-06-01 ANGIOMED GMBH & CO. MEDIZINTECHNIK KG Protesis endovascular con valvula.
US6966925B2 (en) 2000-12-21 2005-11-22 Edwards Lifesciences Corporation Heart valve holder and method for resisting suture looping
US6964682B2 (en) 2000-12-21 2005-11-15 Edwards Lifesciences Corporation Heart valve holder that resist suture looping
US20050182483A1 (en) 2004-02-11 2005-08-18 Cook Incorporated Percutaneously placed prosthesis with thromboresistant valve portion
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
ATE272369T1 (de) 2001-03-27 2004-08-15 Cook William Europ Gefässtransplantat für die aorta
US7037334B1 (en) 2001-04-24 2006-05-02 Mitralign, Inc. Method and apparatus for catheter-based annuloplasty using local plications
DE10121210B4 (de) 2001-04-30 2005-11-17 Universitätsklinikum Freiburg Verankerungselement zur intraluminalen Verankerung eines Herzklappenersatzes und Verfahren zu seiner Herstellung
US6936067B2 (en) 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US7377938B2 (en) 2001-07-19 2008-05-27 The Cleveland Clinic Foundation Prosthetic cardiac value and method for making same
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US7125421B2 (en) 2001-08-31 2006-10-24 Mitral Interventions, Inc. Method and apparatus for valve repair
US7025760B2 (en) 2001-09-07 2006-04-11 Medtronic Minimed, Inc. Method and system for non-vascular sensor implantation
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US6790237B2 (en) 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6978176B2 (en) 2001-12-08 2005-12-20 Lattouf Omar M Treatment for patient with congestive heart failure
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US20030130729A1 (en) 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
US7018404B2 (en) 2002-01-24 2006-03-28 St. Jude Medical, Inc. Conduit for aorta or pulmonary artery replacement
US20030225420A1 (en) 2002-03-11 2003-12-04 Wardle John L. Surgical coils and methods of deploying
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US7160320B2 (en) 2002-04-16 2007-01-09 The International Heart Institute Of Montana Foundation Reed valve for implantation into mammalian blood vessels and heart with optional temporary or permanent support
WO2003094795A1 (en) 2002-05-10 2003-11-20 Cordis Corporation Method of making a medical device having a thin wall tubular membrane over a structural frame
US7101395B2 (en) 2002-06-12 2006-09-05 Mitral Interventions, Inc. Method and apparatus for tissue connection
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
US7172625B2 (en) 2002-07-16 2007-02-06 Medtronic, Inc. Suturing rings for implantable heart valve prostheses
US7041132B2 (en) 2002-08-16 2006-05-09 3F Therapeutics, Inc, Percutaneously delivered heart valve and delivery means thereof
US6875231B2 (en) 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
US20050119735A1 (en) 2002-10-21 2005-06-02 Spence Paul A. Tissue fastening systems and methods utilizing magnetic guidance
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
US7159593B2 (en) 2003-04-17 2007-01-09 3F Therapeutics, Inc. Methods for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7175656B2 (en) 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
EP1615595B1 (en) 2003-04-24 2009-10-21 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
RU2006103367A (ru) 2003-07-08 2006-06-27 Вентор Текнолоджиз Лтд. (Il) Имплантируемые протезные устройства, в частности, для трансартериальной доставки при лечении аортального стеноза и способы имплантации таких устройств
WO2005009285A2 (en) 2003-07-21 2005-02-03 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
DE10334868B4 (de) 2003-07-29 2013-10-17 Pfm Medical Ag Implantierbare Einrichtung als Organklappenersatz, dessen Herstellungsverfahren sowie Grundkörper und Membranelement dafür
EP1659992B1 (en) 2003-07-31 2013-03-27 Cook Medical Technologies LLC Prosthetic valve devices and methods of making such devices
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
EG24012A (en) 2003-09-24 2008-03-23 Wael Mohamed Nabil Lotfy Valved balloon stent
US20050075713A1 (en) 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
US7186265B2 (en) 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
CN100589779C (zh) 2003-12-23 2010-02-17 萨德拉医学公司 可再定位的心脏瓣膜
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
WO2005070343A1 (fr) 2003-12-23 2005-08-04 Laboratoires Perouse Necessaire destine a etre implante dans un conduit
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137691A1 (en) 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7099009B2 (en) 2004-01-08 2006-08-29 International Business Machines Corporation Automated material handling laser alignment tool
US7862610B2 (en) 2004-01-23 2011-01-04 James Quintessenza Bicuspid vascular valve and methods for making and implanting same
US7597711B2 (en) 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
ATE455520T1 (de) 2004-01-27 2010-02-15 Med Inst Inc Widerhaken zur befestigung an einer medizinischen prothese
US7470285B2 (en) 2004-02-05 2008-12-30 Children's Medical Center Corp. Transcatheter delivery of a replacement heart valve
US7311730B2 (en) 2004-02-13 2007-12-25 Shlomo Gabbay Support apparatus and heart valve prosthesis for sutureless implantation
NL1025830C2 (nl) 2004-03-26 2005-02-22 Eric Berreklouw Samenstel omvattende een ring voor bevestiging in een door lichaamsweefsel omgeven doorgang alsmede een applicator voor het in de doorgang plaatsen van de ring.
WO2005096993A1 (en) 2004-03-31 2005-10-20 Med Institute, Inc. Endoluminal graft with a prosthetic valve
CN101052359A (zh) 2004-04-23 2007-10-10 3F医疗有限公司 可植入的人工瓣膜
US8377118B2 (en) 2004-05-05 2013-02-19 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
US20060122692A1 (en) 2004-05-10 2006-06-08 Ran Gilad Stent valve and method of using same
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
US7704277B2 (en) 2004-09-14 2010-04-27 Edwards Lifesciences Ag Device and method for treatment of heart valve regurgitation
AU2004324043A1 (en) 2004-10-02 2006-04-20 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
US20060085060A1 (en) 2004-10-15 2006-04-20 Campbell Louis A Methods and apparatus for coupling an allograft tissue valve and graft
US7641687B2 (en) 2004-11-02 2010-01-05 Carbomedics Inc. Attachment of a sewing cuff to a heart valve
US20060161249A1 (en) 2004-11-22 2006-07-20 Fidel Realyvasquez Ring-shaped valve prosthesis attachment device
US20060122634A1 (en) 2004-12-03 2006-06-08 Ino Takashi H Apparatus and method for delivering fasteners during valve replacement
US7989157B2 (en) 2005-01-11 2011-08-02 Medtronic, Inc. Solution for storing bioprosthetic tissue used in a biological prosthesis
EP1838247A4 (en) 2005-01-21 2009-06-10 Innovia Llc VALVULE-STENT AND DEPLOYMENT CATHETER
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
WO2006089236A1 (en) 2005-02-18 2006-08-24 The Cleveland Clinic Foundation Apparatus and methods for replacing a cardiac valve
JP4740963B2 (ja) * 2005-02-28 2011-08-03 メドテンティア インターナショナル リミテッド オイ 心臓弁の機能改善装置
US8083793B2 (en) 2005-02-28 2011-12-27 Medtronic, Inc. Two piece heart valves including multiple lobe valves and methods for implanting them
US20060195186A1 (en) 2005-02-28 2006-08-31 Drews Michael J Connectors for two piece heart valves and methods for implanting such heart valves
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
JP4819880B2 (ja) 2005-04-19 2011-11-24 クゥアルコム・インコーポレイテッド 無線通信システムにおける接続故障報告
US20060259135A1 (en) 2005-04-20 2006-11-16 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
US20060271172A1 (en) 2005-05-16 2006-11-30 Hassan Tehrani Minimally Invasive Aortic Valve Replacement
EP2901967B1 (en) 2005-05-24 2019-10-02 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
WO2006130505A2 (en) 2005-05-27 2006-12-07 Arbor Surgical Technologies, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US7238200B2 (en) 2005-06-03 2007-07-03 Arbor Surgical Technologies, Inc. Apparatus and methods for making leaflets and valve prostheses including such leaflets
WO2007006057A1 (en) 2005-07-06 2007-01-11 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
WO2007009117A1 (en) 2005-07-13 2007-01-18 Arbor Surgical Technologies, Inc. Two-piece percutaneous prosthetic heart valves and methods for making and using them
WO2007025028A1 (en) 2005-08-25 2007-03-01 The Cleveland Clinic Foundation Percutaneous atrioventricular valve and method of use
CN102113922B (zh) 2005-09-07 2013-03-27 梅德坦提亚国际有限公司 用于改善心脏瓣膜功能的装置
US20070078510A1 (en) 2005-09-26 2007-04-05 Ryan Timothy R Prosthetic cardiac and venous valves
US20070129794A1 (en) 2005-10-05 2007-06-07 Fidel Realyvasquez Method and apparatus for prosthesis attachment using discrete elements
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US7785366B2 (en) 2005-10-26 2010-08-31 Maurer Christopher W Mitral spacer
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
CA2631662C (en) 2005-12-07 2014-08-05 Arbor Surgical Technologies, Inc. Connection systems for two piece prosthetic heart valve assemblies
US20070142907A1 (en) 2005-12-16 2007-06-21 Micardia Corporation Adjustable prosthetic valve implant
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
EP1998719A1 (en) 2006-03-10 2008-12-10 Arbor Surgical Technologies, Inc. Valve introducers and methods for making and using them
US7737060B2 (en) 2006-03-31 2010-06-15 Boston Scientific Scimed, Inc. Medical devices containing multi-component fibers
US7625403B2 (en) 2006-04-04 2009-12-01 Medtronic Vascular, Inc. Valved conduit designed for subsequent catheter delivered valve therapy
US7740655B2 (en) 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US7591848B2 (en) 2006-04-06 2009-09-22 Medtronic Vascular, Inc. Riveted stent valve for percutaneous use
US20070239269A1 (en) 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
US7727276B2 (en) 2006-04-14 2010-06-01 Machiraju Venkat R System and method for heart valve replacement
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
JP5016667B2 (ja) 2006-04-29 2012-09-05 メドトロニック，インコーポレイテッド 複数部材の人工心臓弁アセンブリ並びにそれを用いた装置及びその使用方法
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US20080021546A1 (en) 2006-07-18 2008-01-24 Tim Patz System for deploying balloon-expandable heart valves
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US7575592B2 (en) 2006-10-03 2009-08-18 St. Jude Medical, Inc. Synthetic blood vessel grafts
US20080208327A1 (en) 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
FR2915087B1 (fr) 2007-04-20 2021-11-26 Corevalve Inc Implant de traitement d'une valve cardiaque, en particulier d'une valve mitrale, materiel inculant cet implant et materiel de mise en place de cet implant.
US8147504B2 (en) 2007-05-05 2012-04-03 Medtronic, Inc. Apparatus and methods for delivering fasteners during valve replacement
US8784483B2 (en) 2007-11-19 2014-07-22 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
US20090192604A1 (en) 2008-01-25 2009-07-30 Medtronic, Inc. Sizer, Holder and Delivery Devices for Minimally Invasive Cardiac Surgery
US7993395B2 (en) 2008-01-25 2011-08-09 Medtronic, Inc. Set of annuloplasty devices with varying anterior-posterior ratios and related methods
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US9314335B2 (en) * 2008-09-19 2016-04-19 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
SE534156C2 (sv) 2009-03-11 2011-05-17 Tetra Laval Holdings & Finance Förfarande för montering av ett fönster för utgående elektroner och en fönsterenhet för utgående elektroner
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
KR20110138289A (ko) 2009-04-22 2011-12-26 미쓰비시 타나베 파마 코퍼레이션 염기 변이 판별용 프로브 세트 및 염기 변이의 판별 방법
WO2010127041A1 (en) 2009-04-29 2010-11-04 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US8353953B2 (en) 2009-05-13 2013-01-15 Sorin Biomedica Cardio, S.R.L. Device for the in situ delivery of heart valves
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
WO2011035154A1 (en) 2009-09-18 2011-03-24 The Regents Of The University Of California Endovascular prosthetic heart valve replacement
US8377115B2 (en) 2009-11-16 2013-02-19 Medtronic Vascular, Inc. Implantable valve prosthesis for treating venous valve insufficiency
US8449599B2 (en) * 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) * 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US8869982B2 (en) 2009-12-18 2014-10-28 Edwards Lifesciences Corporation Prosthetic heart valve packaging and deployment system
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
WO2011109813A2 (en) 2010-03-05 2011-09-09 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
WO2011111047A2 (en) * 2010-03-10 2011-09-15 Mitraltech Ltd. Prosthetic mitral valve with tissue anchors
US8657872B2 (en) 2010-07-19 2014-02-25 Jacques Seguin Cardiac valve repair system and methods of use
EP2611391B1 (en) 2010-09-01 2017-11-22 Mvalve Technologies Ltd. Cardiac valve support structure
EP2613821B1 (en) 2010-09-07 2023-02-15 Paul A. Spence Cannula systems
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
JP5690106B2 (ja) 2010-09-24 2015-03-25 Ｄｏｗａエコシステム株式会社 鉄粒子を含む有機ハロゲン化合物の分解剤及びその製造方法
US8845720B2 (en) * 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
US8445308B2 (en) 2010-10-15 2013-05-21 Cooledge Lighting Inc. Fabrication of phosphor dots and application of phosphor dots to arrays of lighting elements
CA2822381C (en) * 2010-12-23 2019-04-02 Foundry Newco Xii, Inc. System for mitral valve repair and replacement
EP2663258B1 (de) 2011-01-11 2018-11-21 Hans Reiner Figulla Klappenprothese zum ersatz einer artrioventrikularklappe des herzens
US9364326B2 (en) 2011-06-29 2016-06-14 Mitralix Ltd. Heart valve repair devices and methods
US9078747B2 (en) * 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
EP2620125B1 (en) 2012-01-24 2017-10-11 Medtentia International Ltd Oy An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve
JP6049761B2 (ja) 2012-01-31 2016-12-21 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 僧帽弁ドッキングデバイス、システム、および方法
WO2013175468A2 (en) 2012-05-20 2013-11-28 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve
JP5607695B2 (ja) 2012-09-13 2014-10-15 ファナック株式会社 工作機械の熱変位補正装置
ES2931210T3 (es) 2012-11-21 2022-12-27 Edwards Lifesciences Corp Mecanismos de retención para válvulas cardiacas protésicas
EP2805695A1 (en) 2013-05-21 2014-11-26 Medtentia International Ltd Oy Medical system for annuloplasty
SG10202103500PA (en) 2013-08-12 2021-05-28 Mitral Valve Tech Sarl Apparatus and methods for implanting a replacement heart valve
US10052198B2 (en) 2013-08-14 2018-08-21 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
JP6328242B2 (ja) 2013-08-14 2018-05-23 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 心臓弁置換のためのシステム
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
WO2015124631A2 (en) 2014-02-18 2015-08-27 Medtentia International Ltd Oy Medical device for a cardiac valve implant
US9700412B2 (en) 2014-06-26 2017-07-11 Mitralix Ltd. Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices
CN106714732A (zh) 2014-09-08 2017-05-24 梅德坦提亚国际有限公司 瓣环成形术植入体
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
DE102016001196B4 (de) 2016-02-03 2018-05-30 Audi Ag Schaltungsanordnung und Bordnetz für ein Kraftfahrzeug

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1714766A (zh) * 2000-07-06 2006-01-04 梅德坦蒂亚公司 瓣环成形设备
US20040127982A1 (en) * 2002-10-01 2004-07-01 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US20050203617A1 (en) * 2004-02-27 2005-09-15 Cardiacmd, Inc. Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US7377941B2 (en) * 2004-06-29 2008-05-27 Micardia Corporation Adjustable cardiac valve implant with selective dimensional adjustment
US20090043381A1 (en) * 2004-10-05 2009-02-12 Macoviak John A Atrioventricular valve annulus repair systems and methods including retro-chordal anchors
CN101588771A (zh) * 2006-11-13 2009-11-25 梅德坦蒂亚公司 用于改善心脏瓣膜功能的装置和方法
US20100204785A1 (en) * 2007-09-28 2010-08-12 Alkhatib Yousef F Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
CN103517688A (zh) * 2011-01-11 2014-01-15 汉斯·赖纳·菲古拉 用来替代心脏房室瓣的瓣膜假体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472142A (zh) * 2015-11-17 2018-08-31 爱德华兹生命科学公司 用于设置锚定器的系统和装置
CN108472142B (zh) * 2015-11-17 2020-09-11 爱德华兹生命科学公司 用于设置锚定器的系统和装置
CN112754732A (zh) * 2021-01-20 2021-05-07 上海纽脉医疗科技有限公司 一种介入式人工心脏瓣膜及医用装置
CN112754732B (zh) * 2021-01-20 2024-03-26 上海纽脉医疗科技有限公司 一种介入式人工心脏瓣膜及医用装置

Also Published As

Publication number Publication date
US20130166022A1 (en) 2013-06-27
US10849752B2 (en) 2020-12-01
EP2793752A1 (en) 2014-10-29
CA2859666C (en) 2021-02-09
US20210077259A1 (en) 2021-03-18
US20190201200A1 (en) 2019-07-04
US20170209269A1 (en) 2017-07-27
CA2859666A1 (en) 2013-06-27
US11452602B2 (en) 2022-09-27
US9078747B2 (en) 2015-07-14
WO2013095816A1 (en) 2013-06-27
US10238489B2 (en) 2019-03-26
EP2793752B1 (en) 2021-04-21
US9737401B2 (en) 2017-08-22
US20160367365A1 (en) 2016-12-22
EP2793752A4 (en) 2015-06-03
CN104125817B (zh) 2017-03-22

Similar Documents

Publication Publication Date Title
CN104125817B (zh) 用于置换或修复心脏瓣膜的锚定装置
US20190060070A1 (en) Systems and methods for treating lumenal valves
US8926694B2 (en) Dual valve prosthesis for transcatheter valve implantation
US9295547B2 (en) Prosthesis for transcatheter valve implantation
US8696743B2 (en) Tissue attachment devices and methods for prosthetic heart valves
EP2621408B1 (en) Aortic valve devices
US7815677B2 (en) Reinforcement device for a biological valve and reinforced biological valve
US9814574B2 (en) Non-axisymmetric aortic valve devices
US20160278916A1 (en) Multiple Orifice Implantable Heart Valve and Methods of Implantation
CN108156805A (zh) 二尖瓣瓣膜组件
EP3294214A1 (en) Apparatus and methods for treating cardiac valve regurgitation
JP2002541914A (ja) 大動脈環状形成リング
US20210015615A1 (en) Systems and methods for treating luminal valves

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant