CN104127233A - Nerve regulation apparatus - Google Patents
Nerve regulation apparatus Download PDFInfo
- Publication number
- CN104127233A CN104127233A CN201310161218.0A CN201310161218A CN104127233A CN 104127233 A CN104127233 A CN 104127233A CN 201310161218 A CN201310161218 A CN 201310161218A CN 104127233 A CN104127233 A CN 104127233A
- Authority
- CN
- China
- Prior art keywords
- nerve
- blood vessel
- electrode
- shape
- load bearing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention provides a nerve regulation apparatus which comprises a regulation component and a control component. The regulation component used for regulating the nerve comprises one or multiple electrodes used for transmitting regulation energy to the nerve and an electrode carrying component used for carrying the electrodes. The electrode carrying component is of a first shape and a second shape. When the electrode carrying component is in the first shape, the regulation component is adaptable to moving in blood vessels; when the electrode carrying component is in the second shape, at least one electrode of the regulation component stays at a position suitable for transmitting the regulation energy to the nerve. The control component is used for conveying the regulation component to the position near the nerve and realizing switching between the first shape and the second shape of the electrode carrying component. The nerve regulation apparatus is convenient to operate and capable of regulating multiple nerve points simultaneously, thus work efficiency is improved.
Description
Technical field
The present invention relates to electrosurgery, relate in particular to a kind of for regulating neural device.
Background technology
Intractable hypertension, use still unmanageable hypertension (sBP >=160mmHg) of more than 3 kinds medicine (all having used a diuretic), more common clinically, its paathogenic factor is numerous, pathogenesis is indefinite, medication effect is very poor, and diagnosis and treatment technology are still not mature enough, become one of great difficult problem of hypertension therapeutic.
Up-to-date animal and the clinical experiment digital proof adjusting (for example removing sympathetic nerve) to kidney nerve can be lowered intractable hypertension, the renal artery radiofrequency ablation art that for example latest developments go out significantly enduringly.Renal artery radiofrequency ablation art is a kind of by electrode catheter intravascular is sent into specific part in renal artery, discharges radio-frequency current and causes the necrosis of renal artery sympathetic nerve local solidification, reaches denervated Interventional technology.Radio-frequency current damage range is little, can not cause body harm, and therefore renal artery radiofrequency ablation art has become a kind of orthosympathetic method of renal artery of effectively removing.
In addition, the adjusting of kidney nerve is proved to be the multiple disease relevant to kidney had to certain effect, the relevant disease that particularly kidney sympathetic nerve overactivity causes.For example, congestive heart failure (CHF) can cause abnormal high kidney sympathetic nerve activation, thereby causes the water removed from health and the minimizing of sodium, and increases the secretion of feritin.The renin secretion increasing causes kidney vasoconstriction, causes the reduction of renal blood flow.Thereby kidney can make the spiral decline of heart failure condition extend for the reaction of heart failure.
Although have report in pertinent literature or patent for regulating the orthosympathetic related equipment of renal artery, current existing apparatus has the defects such as the high or inefficiency of operation inconvenience, cost of manufacture.
Given this, the invention provides a kind of new for regulating neural device.
Summary of the invention
The object of this invention is to provide a kind of operation and treat easily the device of relevant disease for regulating nerve.
Provided by the present invention for regulating neural device, comprise the adjusting part for regulating described nerve, described adjusting part comprises one or more electrodes for adjusting energy being delivered to described nerve and for carrying the electrode load bearing component of described electrode, it is characterized in that, described electrode load bearing component has the first shape and the second shape, under described the first shape, described adjusting part moves in being adapted at blood vessel, and under described the second shape, at least one electrode of described adjusting part is in being applicable to described adjusting energy to be delivered to the position of described nerve; Described device also comprises for described adjusting part being transported near the position of described nerve the Control Component that described electrode load bearing component is converted between the first shape and the second shape.
Preferably, described nerve is the kidney nerve being positioned on people's renal artery, and described " near the position of described nerve " refers to and be positioned at described renal artery.
Preferably, described adjusting refers to the activation of being removed or reduced described nerve by damage or non-invasive mode.
Preferably, described energy is one or more in heat, cooling, electromagnetic energy, radio frequency, ultrasound wave, microwave or luminous energy.
Preferably, described blood vessel behaviour renal artery.
Preferably, described " being adapted at moving in blood vessel " refers in the time that described adjusting part moves in blood vessel, and described adjusting part is injured blood vessel wall not.
Preferably, described " being adapted at moving in blood vessel " refers to described adjusting part full-size is upwards not more than the internal diameter of described blood vessel in the footpath of described blood vessel.
Preferably, described " being adapted at moving in blood vessel " refers to described adjusting part full-size is upwards not more than 4mm in the footpath of described blood vessel.
Preferably, described " being applicable to described adjusting energy to be delivered to the position of described kidney nerve " refers in the time that described adjustment member is in blood vessel, the position of at least one electrode in contact blood vessel wall.
Preferably, described " being applicable to described adjusting energy to be delivered to the position of described kidney nerve " refers to described adjusting part full-size is upwards 4-8mm in the footpath of described blood vessel, and at least one electrode is in full-size place.
Preferably, described adjusting part comprises multiple electrodes, and under described the second shape, multiple electrodes of described adjusting part are all in being applicable to described adjusting energy to be delivered to the position of described nerve.
Preferably, the inside of described electrode load bearing component is provided with the wire for described electrode being connected to energy generation apparatus.
Preferably, described electrode is ring-type or tubulose, is socketed on the outside of described electrode load bearing component.
Preferably, described second be shaped as described electrode load bearing component in self shape not being subject under External Force Acting.
Preferably, near the far-end of described electrode load bearing component or far-end, be provided with the flag member for show electrode load bearing component position under X-ray.
Preferably, the far-end of described electrode load bearing component is provided with the guard block for reducing or avoid vascular damaged.More preferably, the material of described guard block is softer than the material of electrode load bearing component.
Preferably, first of described electrode load bearing component be shaped as elongate, bar shaped, thread or fibrous one.
Preferably, second of described electrode load bearing component be shaped as spiral type.More preferably, described spiral diameter is 4-8mm.
Preferably, the number of described electrode is 2-6, and when described electrode load bearing component is during in the second shape, the distance of adjacent electrode in the axial direction of described blood vessel is 4-6mm.More preferably, the number of described electrode is 4.
Preferably, described Control Component comprises for described adjusting part being transported to the transfer unit near the position of described nerve, described transfer unit be shaped as elongate, bar shaped, thread or fibrous one, the far-end of described transfer unit is connected with the near-end of described electrode load bearing component.Preferred, the material of described transfer unit and described electrode load bearing component is identical and be connected as a single entity.In addition, described transfer unit preferably has and described adjusting part can be transported to the arteriorenal length of people from human radial artery.Preferred, the length of described transfer unit is 130cm-160cm.
Preferably, described Control Component comprises the shape control unit part for described electrode load bearing component is converted between the first shape and the second shape.
Preferably, the inside of described electrode load bearing component and described transfer unit has the shape control channel for holding described shape control unit part, described shape control unit part is arranged in the shape control channel of described transfer unit, and described electrode load bearing component and described shape control unit part are configured to utilize described shape control unit part in the turnover of the shape control channel of described electrode load bearing component, described electrode load bearing component to be changed between the first shape and the second shape.More preferably, affiliated Control Component comprises the handle gripping for user, described transfer unit is installed on described handle, described handle has the shape control channel of holding described shape control unit part, and described shape control unit part extends to the outside of described handle by the shape control channel of described handle.
Preferably, described shape control unit part is coated at described transfer unit and can slides along described transfer unit, described electrode load bearing component and described shape control unit part are configured: in the time that described shape control unit part is coated at described electrode load bearing component and electrode, described electrode load bearing component is in the first shape, in the time that described shape control unit part departs from described electrode load bearing component and electrode, described electrode load bearing component is in the second shape.More preferably, described Control Component comprises the handle gripping for user, and described transfer unit is installed on described handle.Or, near the far-end of described shape control unit part or far-end, be provided for the flag member of display shape control assembly position under X-ray.
Provided by the present invention for regulating neural device operation convenient, and can regulate to multiple neural sites, thereby increase work efficiency. simultaneously
Below with reference to accompanying drawing, the technique effect of design of the present invention, concrete structure and generation is described further, to understand fully object of the present invention, feature and effect.
Brief description of the drawings
Fig. 1 is the structural representation of people's kidney and linked groups.
Fig. 2 is the arteriorenal structural representation of people.
Fig. 3 is provided by the invention for regulating a kind of ingredient schematic diagram of detailed description of the invention of neural device, the figure shows the first shape of electrode load bearing component.
Fig. 4 be shown in Fig. 3 for regulating the schematic diagram of another kind of state of neural device, the figure shows the second shape of electrode load bearing component.
Fig. 5 be shown in Fig. 3 for regulating the structural representation of neural device.
Fig. 6 is provided by the invention for regulating the structural representation of another kind of detailed description of the invention of neural device.
Detailed description of the invention
Below with the drawings and specific embodiments, the present invention will be further described.For convenience of explanation, the one end in the neural site regulating by the close user (or handle) of device or parts or away from needs in the present invention is called " near-end ", and one end away from user (or handle) or the close neural site that need to regulate of device or parts is called to " far-end ".
Fig. 1-Fig. 5 shows provided by the present invention for regulating the preferred detailed description of the invention of one of neural device and using method thereof.This detailed description of the invention is example for the device of mediator's kidney nerve.
Fig. 1-Fig. 2 shows linked groups and the structure of people's kidney.As shown in Figure 1, Ren Shen linked groups comprises kidney K anatomically, and kidney K is supplied to oxygen containing blood by renal artery RA.Renal artery RA is connected to heart via the aortic artery AA of abdominal part.The blood of deoxidation flows to heart via renal veins RV and postcava IVC from kidney.Fig. 2 is the anatomical part of diagram kidney in more detail.More specifically, kidney anatomy also comprises along the neural RN of kidney of the axial L longitudinal extension of renal artery RA.The neural RN of kidney is generally in the adventitia of described tremulous pulse.In this detailed description of the invention, the device providing is for regulating the neural RN of the kidney being positioned on renal artery RA, and described adjusting refers to the activation of being removed or reduced the neural RN of kidney by damage or non-invasive mode.As the variation of this detailed description of the invention, for example, if (need to regulate the nerve at other position, heart related neural), or (for example need other regulative mode, need to further improve neural activation), those skilled in the art can make according to the present invention can adjustment rational expectation, that do not need to be put to creative work.
Fig. 3 and Fig. 4 show in this detailed description of the invention for regulating the ingredient of neural device.As shown in Figure 3 and Figure 4, first this device comprises adjusting part 100; Adjusting part 100 comprises electrode 101 and electrode load bearing component 102.When electrode near need to regulate neural site time, electrode discharges certain energy and acts on this nerve site, thereby plays the effect that regulates this nerve site (for example, reduce or eliminate orthosympathetic activation).
Electrode can be realized this object by heat being delivered to this nerve site.For example, heat transfer heating mechanism for neuroregulation can comprise heating ablation and the non-thermal change melting or damage, for example, the temperature of target nerve fiber can be raise exceed required threshold value and move and realize the non-thermal change melting, or exceedes higher temperature to realize the thermal change melting.For example, target temperature can be in about 37 DEG C-45 DEG C (for the thermal change temperature of non-heating ablation), or described target temperature can be at about 45 DEG C or higher, for the thermal change melting.
Electrode also can be by realizing this object by cooling this nerve site that is delivered to.For example, the temperature of target nerve fiber is reduced to approximately 20 DEG C below to realize non-freezing thermal change, or the temperature of target nerve fiber is reduced to approximately 0 DEG C below to realize freezing thermal change.
Electrode also can be realized by energy field being applied to target nerve fiber.This energy field can comprise: electromagnetic energy, radio frequency, ultrasound wave (comprising high-intensity focusing ultrasonic wave), microwave, luminous energy (comprising laser, infrared ray and near infrared ray) etc.For example, thermoinducible neuroregulation can realize by pulse or continuous heat energy field is delivered to target nerve fiber.Wherein, a kind of energy mode of comparative optimization is the pulse heat energy of pulse radiation frequency electric field or other type.The pulse heat energy of pulse radiation frequency electric field or other type can facilitate larger heat rank, longer total duration and/or the interior kidney neuroregulation of better controlled blood vessel to treat.
No matter by which kind of energy mode realized and regulated neural object, in the time that user uses device provided by the present invention to carry out work, electrode need to for example, be electrically connected with the equipment that produces this energy (radiofrequency generator) or make electrode itself produce this energy.These equipment and electrode and these equipment be connected to prior art well-known to those skilled in the art (for example, be provided for connecting the interface of these equipment in apparatus of the present invention, can realize plug and play when use), no longer describe in detail here.
In this detailed description of the invention, electrode 101 near the mode in the neural site of kidney that needs to regulate is: enter human body via blood vessel, by renal artery inwall near neural site.Therefore, in the time that the device that uses this detailed description of the invention to provide carries out work, technical issues that need to address are: thus should realize the nerve that electrode can be close to internal blood vessel effect relevant position, need again electrode can move easily in blood vessel, and injured blood vessel wall not.This detailed description of the invention adopts following technical scheme to solve this technical problem: configured electrodes load bearing component 102 makes it to have the first shape (as shown in Figure 3) and the second shape (as shown in Figure 4).As shown in Figure 3, first is shaped as straight or approaches straight bar shaped (or elongate is fibrous or thread), and the cross section of this bar shaped is preferably circle or sub-circular, and the widest part of cross section is less than the interior diameter of blood vessel.Like this, under the first shape, in the time that adjusting part 100 moves in blood vessel, adjusting part 100 can injured blood vessel wall.In the time need to regulating the nerve on renal artery, because the arteriorenal interior diameter of people is generally 4-7mm, therefore, adjusting part 100 is not more than 4mm in arteriorenal footpath full-size upwards, preferably be set to 1-2mm, both can meet convenient movement in blood vessel, and there is again enough rigidity and be convenient to and make, and can reduce the size of patient's wound.As the variation of this detailed description of the invention, the first shape also can allow certain bending or corrugated bending, and its cross section can be also other shape, needs only its smooth surface, can be easily injured blood vessel wall at blood in-pipe and not.
Under the second shape of electrode load bearing component, the electrode of adjusting part 100 is in being applicable to adjusting energy to be delivered to the position of kidney nerve.As shown in Figure 4, in this detailed description of the invention, the second shape entirety of electrode load bearing component 102 is spiral type.In the time that electrode load bearing component 102 entirety be spiral type, in the footpath of blood vessel upwards (perpendicular to blood vessel axially), the widest part of adjusting part 100 is large than the first shape, the electrode that so just can make it to carry comes close to or in contact with blood vessel wall, thereby close kidney nerve.Through groping, consider that blood vessel has certain elasticity, it is more suitable that the diameter of spiral is set to 4-8mm.For example, for example, for the less individuality of renal artery internal diameter (internal diameter be about 4mm), diameter that can spiral is set to 5mm left and right; For example, for the larger individuality of renal artery internal diameter (internal diameter be about 7mm), diameter that can spiral is set to 8mm left and right.As the variation of this detailed description of the invention, the second shape can be also other shape, for example, has round and smooth bending irregular shape, as long as in the time that described electrode load bearing component is in blood vessel, and the position of electrode in contact blood vessel wall.
In this detailed description of the invention, electrode 101 is ring-type, and is socketed in the outer surface of electrode load bearing component 102.Like this, in the time that electrode load bearing component 102 is spiral type (in renal artery), the position (near kidney nerve) of the electrode 101 on electrode load bearing component 102 in contact renal artery inwall, so just can carry out adjusting work.For electrode 101 is firmly arranged on electrode load bearing component 102, and reduce the damage to blood vessel wall as far as possible, can the ring-shaped depression that shape is mated with electrode 101 be set at the outer surface of electrode load bearing component 102, electrode 101 is fixed on to corresponding position.In addition, the outer surface of electrode 101 forms relative smooth curved surface with the outer surface in the region of adjacent electrode load bearing component 102, to reduce the damage to blood vessel wall.As the variation of this detailed description of the invention, electrode 101 also can be arranged on electrode load bearing component 102 by alternate manner, and for example, electrode 101 is block, the outer surface of intercalation electrode load bearing component 102.In addition, the inside of electrode load bearing component 102 is provided with for example, wire (not shown) for electrode 101 being connected to energy generation apparatus (radiofrequency generator), in the time thering is multiple electrode, the many wires that respectively multiple electrodes are connected to energy generation apparatus need to be set.Element (for example, thermocouple) and the corresponding wire that on electrode load bearing component 102, can also be provided for measuring temperature, the routine setting that is arranged as this area of wire and thermocouple, no longer describes in detail here.
In this detailed description of the invention, the number of electrode 101 is four.When electrode load bearing component 102 is when the second shape (helical form), the distance B of adjacent electrode in the axial direction of blood vessel is that 4-6mm is more suitable.In general, while carrying out the neural ablative surgery of kidney, the 5-8 of a kidney nerve site is melted.Therefore, while utilizing device in this detailed description of the invention to carry out work, the location (making electrode contact blood vessel) of Primary regulation assembly can complete melting of four sites, can and complete the positioning instant that whole ablative surgery only need to carry out twice adjusting part.As the variation of this detailed description of the invention, the number of electrode also can be set to 2-6, if but number is more, can increase the cost of manufacture of whole device; If number is less, can reduce the work efficiency of ablative surgery.The material of electrode can adopt the better or more stable metal or metal alloy of biocompatibility, for example platinum group metal (as platinumiridio).
In this detailed description of the invention, the far-end of electrode load bearing component 102 is also provided with flag member 103 and guard block 104.The effect of flag member 103 is show electrode load bearing component positions under X-ray, and its material can be selected the better or more stable metal or metal alloy of biocompatibility, for example platinum group metal (as platinumiridio).Flag member 103 can be also ring-type, is socketed in the outer surface of the far-end of electrode load bearing component 102.The effect of guard block 104 is minimizings or avoids vascular damaged; guard block 104 can be one section of relatively soft (for example relatively soft high molecule plastic of material of material; as Pebax2533, Pebax3533, TPU etc.) object; be connected in the far-end of electrode load bearing component 102, avoid the far-end injured blood vessel of electrode load bearing component 102.
Device in this detailed description of the invention also comprises Control Component 200, and Control Component 200 comprises for adjusting part 100 being transported near the transfer unit 201 of the position of kidney nerve (being transported in renal artery) and making shape control unit part 202(that electrode load bearing component 102 converts between the first shape and the second shape as shown in Figure 3 and Figure 4).Fig. 5 shows the structure of transfer unit 201 and shape control unit part 202.As shown in Figure 5, the far-end of transfer unit 201 is connected with the near-end of electrode load bearing component 102, if they adopt same material, and also can be one-body molded.Transfer unit 201 be shaped as bar shaped (or elongate is fibrous or thread), have and be adapted at rigidity and flexible mobile in blood vessel, its length can arrange as required.For example, if user need to be by being transported to adjusting part 100 in renal artery through femoral artery place, the length that can configure transfer unit 201 is the most suitable to 130cm(105cm left and right at 80cm); If user need to be transported to adjusting part 100 in renal artery by trans-radial place, the length that can configure transfer unit 201 is the most suitable to 160cm(155cm left and right at 130cm).The cross section of transfer unit 201 is preferably circle, its diameter is not more than the internal diameter of the blood vessel that needs process, and diameter is preferably 1-2mm left and right, both can meet in blood vessel convenient mobile, there is again enough rigidity and be convenient to and make, and can reduce the size of patient's wound.
In this detailed description of the invention, electrode load bearing component 102 and transfer unit 201 inside are provided with the shape control channel for holding shape control unit part 202, shape control unit part 202 be shaped as bar shaped (or elongate is fibrous or thread), be straight or approach straight bar shaped near position far away, shape control unit part 202 is through the whole shape control channel of transfer unit 201 and extend beyond the near-end of transfer unit 201.In addition, self shape that second of electrode load bearing component 102 is shaped as electrode load bearing component while not being subject to External Force Acting, and electrode load bearing component 102 adopts elastic memory material to be made.That is to say, electrode load bearing component 102 entirety in the situation that not being subject to External Force Acting is spiral type.This detailed description of the invention adopts following technical scheme control electrode load bearing component 102 to change between the first shape and the second shape: shape control unit part 202 adopts the material harder than the material of electrode load bearing component to make, for example, the material of electrode load bearing component 102 is high molecule plastic (as Pebax3533, Pebax4033, TPU etc.), high molecule plastic inside or inwall arrange elastic memory material titanium-nickel wire (ensureing that electrode load bearing component 102 returns to the second shape in the situation that is not subject to External Force Acting), and the material of shape control unit part 202 is rustless steel; Like this, user just can pinch the operation that the near-end (being exposed at the outside of transfer unit 201) of shape control unit part 202 pushes and retracts, and shape control unit part 202 is entered and depart from the shape control channel of electrode load bearing component 102; In the time that shape control unit part 202 enters the shape control channel of electrode load bearing component 102, because the hardness ratio electrode load bearing component 102 of the material of shape control unit part 202 is large, shape control unit part 202 can present the first shape (straight or approach straight bar shaped); In the time that shape control unit part 202 departs from the shape control channel of electrode load bearing component 102, due to the elastic acting force of electrode load bearing component 102 self, electrode load bearing component 102 returns to the second shape (helical form); Realize therefrom electrode load bearing component 102 changes between the first shape and the second shape.
In addition, in this detailed description of the invention, for user grips conveniently, Control Component 200 also comprises the handle 203 that is suitable for user gripping, transfer unit 201 is installed on handle 203, in handle 203, also have the shape control channel of holding shape control unit part 202, shape control unit part 202 extends to the outside of handle 203 by the shape control channel of handle 203, pushes and the operation of the shape control unit part 202 of pulling back for user.
When the inside of electrode load bearing component 102 and transfer unit 201 need to hold shape control unit part 202 and multiple conducting wires simultaneously, (example is as described above, when carrying multiple electrodes on electrode load bearing component 102, and while being also provided with the elements such as thermocouple, need to respectively electrode and these elements be connected to corresponding equipment with multiple conducting wires) time, a kind of preferred mode is at electrode load bearing component 102 and transfer unit 201 is interior arranges two or more separate passages, shape control unit part 202 uses one of them autonomous channel, wire uses other one or more passages (as long as wire can insulate each other).
A kind of detailed description of the invention of shape control unit part 202 has more than been described.As the variation of this detailed description of the invention, shape control unit part 202 can also be realized electrode load bearing component 102 by another kind of mode and change between the first shape and the second shape.As shown in Figure 6, the body that shape control unit part 202 is bar shaped (or elongate is fibrous or thread), is straight or approaches straight bar shaped body, also can slide along transfer unit 201 in the outside that is coated at transfer unit 201 near the part of far-end.Shape control unit part 202 adopts the material harder than the material of electrode load bearing component 102 to make, for example, the material of electrode load bearing component 102 is relatively soft high molecule plastic (as Pebax3533, Pebax4033, TPU etc.), and the material of shape control unit part 202 is relatively hard high molecule plastic (as ABS, PC etc.); Like this, user just can grip the operation that the near-end of shape control unit part 202 pushes and retracts, and makes shape control unit part 202 be coated at electrode load bearing component 102 and departs from electrode load bearing component 102; In the time that shape control unit part 202 is coated at electrode load bearing component 102, because the hardness ratio electrode load bearing component 102 of the material of shape control unit part 202 is large, shape control unit part 202 can present the first shape (straight or approach straight bar shaped); In the time that shape control unit part 202 departs from electrode load bearing component 102, due to the elastic acting force of electrode load bearing component 102 self, electrode load bearing component 102 returns to the second shape (helical form); Realize therefrom electrode load bearing component 102 changes between the first shape and the second shape.In addition, near the far-end of shape control unit part 202 or far-end, can also be provided for the flag member of display shape control assembly 202 positions under X-ray, in order to avoid in the time of operation, shape control unit part 202 stretches out outside electrode load bearing component 102 too much, thus damage nephridial tissue.
More than describe provided by the invention for regulating the detailed description of the invention of neural device.Be to be understood that, those of ordinary skill in the art just can design according to the present invention make many modifications and variations without creative work, as long as this adjusting part can be transported to the neural site regulating near needing via blood vessel, and operational shape control assembly changes electrode load bearing component between the first shape and the second shape, just can realize the object of neuroregulation and treatment.For example, can use for reference application number and be some disclosed schemes of Chinese patent application of 200780031879.4 and 200980157662.7 and realize this object, specifically can adopt provided device to drive the motion of shape control unit part.Therefore, all those skilled in the art, all should be in by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
Claims (10)
1. one kind for regulating neural device, comprise the adjusting part for regulating described nerve, described adjusting part comprises one or more electrodes for adjusting energy being delivered to described nerve and for carrying the electrode load bearing component of described electrode, it is characterized in that, described electrode load bearing component has the first shape and the second shape, under described the first shape, described adjusting part moves in being adapted at blood vessel, and under described the second shape, at least one electrode of described adjusting part is in being applicable to described adjusting energy to be delivered to the position of described nerve; Described device also comprises for described adjusting part being transported near the position of described nerve the Control Component that described electrode load bearing component is converted between the first shape and the second shape.
2. device according to claim 1, is characterized in that, described nerve is the kidney nerve being positioned on people's renal artery, and described " near the position of described nerve " refers to and be positioned at described renal artery.
3. device according to claim 1, is characterized in that, described adjusting refers to the activation of being removed or reduced described nerve by damage or non-invasive mode.
4. device according to claim 1, is characterized in that, described energy is one or more in heat, cooling, electromagnetic energy, radio frequency, ultrasound wave, microwave or luminous energy.
5. device according to claim 1, is characterized in that, described blood vessel behaviour renal artery.
6. device according to claim 1, is characterized in that, described " being adapted at moving in blood vessel " refers in the time that described adjusting part moves in blood vessel, and described adjusting part is injured blood vessel wall not.
7. device according to claim 1, is characterized in that, described " being adapted at moving in blood vessel " refers to described adjusting part, and in the footpath of described blood vessel, full-size is upwards not more than the internal diameter of described blood vessel.
8. device according to claim 1, is characterized in that, described " being adapted at moving in blood vessel " refers to described adjusting part, and in the footpath of described blood vessel, full-size is upwards not more than 4mm.
9. device according to claim 1, is characterized in that, described " being applicable to described adjusting energy to be delivered to the position of described kidney nerve " refers in the time that described adjustment member is in blood vessel, the position of at least one electrode in contact blood vessel wall.
10. device according to claim 1, it is characterized in that, described " being applicable to described adjusting energy to be delivered to the position of described kidney nerve " refers to described adjusting part full-size is upwards 4-8mm in the footpath of described blood vessel, and at least one electrode is in full-size place.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310161218.0A CN104127233B (en) | 2013-05-03 | 2013-05-03 | It is a kind of for adjust nerve device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310161218.0A CN104127233B (en) | 2013-05-03 | 2013-05-03 | It is a kind of for adjust nerve device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104127233A true CN104127233A (en) | 2014-11-05 |
| CN104127233B CN104127233B (en) | 2019-02-22 |
Family
ID=51800269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310161218.0A Active CN104127233B (en) | 2013-05-03 | 2013-05-03 | It is a kind of for adjust nerve device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104127233B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106852703A (en) * | 2015-12-08 | 2017-06-16 | 上海安通医疗科技有限公司 | A kind of radio frequency ablation catheter for renal artery |
| WO2017132935A1 (en) * | 2016-02-04 | 2017-08-10 | 上海安通医疗科技有限公司 | Multi-electrode renal artery ablation catheter |
| JP2018515226A (en) * | 2015-05-13 | 2018-06-14 | 上▲海▼魅▲麗▼▲緯▼叶医▲療▼科技有限公司 | Ripple type high frequency ablation catheter having adhesion adjusting wire and apparatus therefor |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375654B1 (en) * | 2000-05-19 | 2002-04-23 | Cardiofocus, Inc. | Catheter system with working portion radially expandable upon rotation |
| US6485487B1 (en) * | 1998-05-05 | 2002-11-26 | Cardiac Pacemakers, Inc. | RF ablation apparatus having high output impedance drivers |
| CN1549694A (en) * | 2001-05-01 | 2004-11-24 | �����ɷ� | Helically shaped electrophysiology catheter |
| CN102198015A (en) * | 2011-05-03 | 2011-09-28 | 上海微创电生理医疗科技有限公司 | Retractable spiral laminar ring type electrode catheter |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202437329U (en) * | 2012-01-10 | 2012-09-19 | 上海安通医疗科技有限公司 | Manipulative radiofrequency catheter electrode device |
| CN102688090A (en) * | 2012-04-29 | 2012-09-26 | 殷跃辉 | Bidirectionally controllable saline-perfusion renal artery radiofrequency ablation catheter |
| CN102846374A (en) * | 2011-06-30 | 2013-01-02 | 韦伯斯特生物官能(以色列)有限公司 | Catheter with variable arcuate distal section |
| CN104095679A (en) * | 2013-04-12 | 2014-10-15 | 上海微创电生理医疗科技有限公司 | Multiple-electrode ablation catheter |
-
2013
- 2013-05-03 CN CN201310161218.0A patent/CN104127233B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6485487B1 (en) * | 1998-05-05 | 2002-11-26 | Cardiac Pacemakers, Inc. | RF ablation apparatus having high output impedance drivers |
| US6375654B1 (en) * | 2000-05-19 | 2002-04-23 | Cardiofocus, Inc. | Catheter system with working portion radially expandable upon rotation |
| CN1549694A (en) * | 2001-05-01 | 2004-11-24 | �����ɷ� | Helically shaped electrophysiology catheter |
| CN102198015A (en) * | 2011-05-03 | 2011-09-28 | 上海微创电生理医疗科技有限公司 | Retractable spiral laminar ring type electrode catheter |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN102846374A (en) * | 2011-06-30 | 2013-01-02 | 韦伯斯特生物官能(以色列)有限公司 | Catheter with variable arcuate distal section |
| CN202437329U (en) * | 2012-01-10 | 2012-09-19 | 上海安通医疗科技有限公司 | Manipulative radiofrequency catheter electrode device |
| CN102688090A (en) * | 2012-04-29 | 2012-09-26 | 殷跃辉 | Bidirectionally controllable saline-perfusion renal artery radiofrequency ablation catheter |
| CN104095679A (en) * | 2013-04-12 | 2014-10-15 | 上海微创电生理医疗科技有限公司 | Multiple-electrode ablation catheter |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018515226A (en) * | 2015-05-13 | 2018-06-14 | 上▲海▼魅▲麗▼▲緯▼叶医▲療▼科技有限公司 | Ripple type high frequency ablation catheter having adhesion adjusting wire and apparatus therefor |
| EP3295885A4 (en) * | 2015-05-13 | 2019-02-06 | Shanghai Golden Leaf Med Tec Co., Ltd | Corrugated radiofrequency ablation catheter having wall-attaching adjustment wires and apparatus thereof |
| CN106852703A (en) * | 2015-12-08 | 2017-06-16 | 上海安通医疗科技有限公司 | A kind of radio frequency ablation catheter for renal artery |
| WO2017132935A1 (en) * | 2016-02-04 | 2017-08-10 | 上海安通医疗科技有限公司 | Multi-electrode renal artery ablation catheter |
| CN107028651A (en) * | 2016-02-04 | 2017-08-11 | 上海安通医疗科技有限公司 | A kind of multi-electrode radio frequency ablation catheter for renal artery |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104127233B (en) | 2019-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102551874B (en) | Renal artery radiofrequency ablation catheter | |
| CN106420045B (en) | Catheter apparatus, systems, and methods for renal neuromodulation | |
| JP4916629B2 (en) | Catheter with cooled linear electrodes | |
| CN103027745B (en) | Have for the pipe guide of the multiple electrode array of kidney neuroregulation and related system and method | |
| US9333113B2 (en) | System and method for denervation | |
| US9737361B2 (en) | System and method for a catheter | |
| CN205433879U (en) | Radiofrequency ablation catheter for renal arteries | |
| EP2890321B1 (en) | Renal rf ablation system with a movable virtual electrode | |
| CN205433878U (en) | Radiofrequency ablation catheter for renal arteries | |
| CN105555348B (en) | With the nerve modulation conduit device of energy delivery thermocouple assembly and system and associated method | |
| CN102198015B (en) | Retractable spiral laminar ring type electrode catheter | |
| CN205814415U (en) | A kind of multi-electrode radio frequency ablation catheter for renal artery | |
| CN103442659A (en) | Ablation catheter equipped with shape memory material | |
| CN105326562A (en) | Catheter device for regulating renal nerves | |
| CN105167840A (en) | Multi-electrode renal artery radiofrequency ablation catheter | |
| CN203042429U (en) | Controllable type radio frequency catheter electrode device | |
| CN103750898A (en) | Intraluminal ablation catheter | |
| CN203970538U (en) | A kind of multi-electrode radio frequency ablation catheter for renal artery | |
| CN203935269U (en) | A kind of for regulating the pipe guide of kidney nerve | |
| CN113939241A (en) | Mapping and ablation catheter with multiple ring segments | |
| CN112741684A (en) | Pulse ablation electrode assembly and pulse ablation catheter | |
| CN104127233A (en) | Nerve regulation apparatus | |
| CN115517759A (en) | Medical ablation catheter, ablation system and use method | |
| CN203790028U (en) | Catheter device used for regulating nerves | |
| CN204072314U (en) | A kind of for regulating neural pipe guide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |