CN104204863B - Contact lens - Google Patents

Contact lens Download PDF

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Publication number
CN104204863B
CN104204863B CN201380018315.2A CN201380018315A CN104204863B CN 104204863 B CN104204863 B CN 104204863B CN 201380018315 A CN201380018315 A CN 201380018315A CN 104204863 B CN104204863 B CN 104204863B
Authority
CN
China
Prior art keywords
contact lens
liquid
silicones
described contact
combination type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380018315.2A
Other languages
Chinese (zh)
Other versions
CN104204863A (en
Inventor
马丁·哥尔勒
托马斯·廓尔迪克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LENSWISTA AG
Original Assignee
LENSWISTA AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LENSWISTA AG filed Critical LENSWISTA AG
Publication of CN104204863A publication Critical patent/CN104204863A/en
Application granted granted Critical
Publication of CN104204863B publication Critical patent/CN104204863B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/00038—Production of contact lenses
    • B29D11/00057—Production of contact lenses characterised by the shape or surface condition of the edge, e.g. flashless, burrless, smooth
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses

Abstract

A kind of silicones contact lens carrying out coating in hydrophiling mode, it has the radial cross-section of inner surface (1) of this contact lens, and described cross section marginal area profile between flex point (6) and outer ledge is convex surface (7).In order to manufacture contact lens, silicones precursor material is incorporated between female molds and male mold and is polymerized there, by the liquid that described contact lens can be made to expand, the contact lens of polymerization is departed from from mould, and complete contact lens without cutting process after PECVD/CVD coats.

Description

Contact lens
Technical field
The application relates to a kind of having excellent " soft " contact lens wearing performance.
Background technology
Conventional contact lens, such as from German Utility Model publication G 87 10 765 U1 known that hidden Shape eyeglass, has the inner radial being made up of relatively hard materials and the radially outer being made up of softer material.In it The most concavely and outer surface protrudes completely on surface, say, that two surfaces are respectively provided with positive gauss curvature.This Kind of known eyeglass is for its wearing comfort and unsatisfactory.
It is also known that can make by polymethyl methacrylate (methyl methacrylate) PMMA Contact lens applies hydrophilic coating (US 5,080,924).But, the wearing comfort of this eyeglass is not There is the satisfactory of anticipation.
Summary of the invention
It is an object of the invention to provide a kind of contact lens with well the most excellent wearing comfort and Its manufacture method.
This problem is solved by the contact lens being made up of silicones, wherein the radial cross-section on inner surface There is between flex point and outer ledge periphery (rim) region (wherein cross-sectional profiles is convex surface), specifically It it is the peripheral edge margin with the radius between 0.1 and 10mm.Due to this periphery contour so that eyeglass is special The most easily it is slid onto on tear film.
In an embodiment, contact lens has the surface layer being made up of hydrophilic material, which further improves pendant Wear comfortableness.
According on the other hand, described problem can solve by the following method, is wherein drawn by silicones precursor material Enter between female molds, male mold and be polymerized, and will be poly-by the liquid that contact lens can be made to expand The contact lens closed removes from mould and just can complete contact lens without edge cuts.Thus, it is to avoid It is considered the appearance with cut edge excitatory.
In an embodiment, to thus obtained crude eyeglass in combination type PECVD/CVD processes Carry out hydrophiling, thus realize coating thick especially.
Accompanying drawing explanation
Other features of the present invention can obtain from the subsequent descriptions of embodiment in conjunction with claims and accompanying drawing Know.The present invention is not limited to described embodiment, but is limited by the scope of appended claim.Special Not, each feature of embodiments of the invention can be implemented as the number different from embodiment set forth below Or combination.Below, with reference to accompanying drawing, embodiment is illustrated, there is shown:
The schematic cross sectional views of the contact lens that Fig. 1 a is located on cornea；
Fig. 1 b is the schematic close up view of the peripheral part of the contact lens of Fig. 1 a；
Fig. 2 is the electron microscope image of the peripheral part of contact lens；
Fig. 3 is showing the fluorogram of face coat；
Fig. 4 is the flow chart of the manufacture method for the contact lens according to the present invention；And
Fig. 5 applies to the sectional view of the shaped device of the manufacture method according to Fig. 4.
Detailed description of the invention
Fig. 1 a and Fig. 1 b shows the general shape of contact lens: the inner surface 1 of positive corneal is (in use This inner surface 1 is floating to be attached on tear film) (that is, circular cone coefficient is about-0.1 to present concavity in part Z at its center Rotationally symmetrical formula aspheric surface to-0.5), the most somewhat present elliptic sharp-pointed (elliptically pointed). In principle, if physiological condition needs, then this inner surface can also deviate from rotationally symmetrical.The outer surface of eyeglass 2 is the natural convex surface that radius amplitude is somewhat different than the radius of inner surface, in order to the diopter needed for offer.? In outboard peripheries part R, curvature or radius value deviation from middle part the most in the following manner: on the outer surface, Ring part 4 contiguous center part diametrically, wherein said ring part (inside) curvature is relatively big, therefore partly Footpath is less.Going up in this section, the another part being adjacent to this part in outside is to bend less cone again The sweep 5 of (not bending) or slightly outwards (that is, hogging bending).For amplitude, herein Curvature always less than (that is, radius always greater than) referring initially to transitional region 4, say, that eyeglass Smoothly finish up.
Inner surface 1 also has the annular region of the adjacent middle section with ellipsoid diametrically, but, Corresponding with radius of curvature bigger in this region, the bending of described annular region is less, thus more flattens out Smooth.This refers to the radius of curvature in cutting plane, described cutting plane i.e. comprises that plane of the optical axis of eyeglass. The line formed by inner surface and cutting plane forms flex point 6, i.e. the first vanishing of this curvature of a curve, is then Just.For Gaussian surface curvature, it means that to the transition of negative value.This region adjacent is region 7, In this region, the inner surface of contact lens is close to overall incisal plane；Here, the main portion of radially cutting plane it is perpendicular to The curvature divided is zero, so that Gaussian surface curvature vanishing, more outwards, i.e. at marginal area immediately In be again transformed on the occasion of.
(it is positioned at surface between this 2 point (being positioned in cutting plane) of curvature flex point 6 and 7 or in this two lines On) between, when radially observing to perimeter from interior zone, there is contact lens gradually from angle The region that film raises.This region is the key of wearing comfort.It has been recognised by the inventors that neither should shape in this region (it may hinder the tear film being positioned on cornea, is even also possible to cut cornea to become to have the sharpest edge In)；Peripheral edge margin the most should not made to have outside edge sharp-pointed, prominent, extremely bending, and (" ski trail is taken turns Wide (Skispitzen-Profil) "), during nictation, this edge can stimulate and moves on to this edge from outside slip Eyelid.On the contrary, according to the present invention without the ring that seamlessly transits towards outer ledge of any sharp edges ground Shape region (seeing Fig. 2) achieves the floating patch of contact lens unperturbed on tear film, and enables eyelid simultaneously Unperturbed is slid onto on contact lens.It was found that along the inner surface radius (i.e. curvature is reciprocal) of radial direction cutting plane Such as between 0.1 and 4mm, or on the one hand it is higher than 0.5mm or/and be on the other hand less than 2mm.Negative Bending area radially extend can be 1 μm to 1mm, such as on the one hand, higher than 10 μm or/and the opposing party Face is less than 100 μm.Replacing an acute angle 8, outward flange itself can include two obtuse angles, wherein as from Fig. 2 Visible, roughly cylindrical outboard peripheries region 9 extends such as 10-30 μm between described obtuse angle.
Fig. 3 shows the fluorogram of face coat, face coat can be used for by the basic material of contact lens, From as hydrophobic silicones hydrophiling.The core of eyeglass is by the poly-diformazan that Shore A hardness is 25 Radical siloxane (dimethyl siloxane) is constituted.In this example, for analysis purpose, the PAA layer applied (polypropylene acid layer) is dyeed by fluorescent dyes rhodamine 6G, and the diffusion depth of fluorescent agent is Determined by Laser Scanning Confocal Microscope.As can be seen, the whole thickness (line width) of PAA coating is several Ten microns (μm).Lens thickness (line interval) in measurement position is 118 μm.This coating passes through PECVD, Prepared by CVD the most again.In the plasma coating stage, pressure ratio is from initial significantly argon excess (> 10:1) Lacking (< 1:10) change towards the same significantly argon drawn to an end, gross pressure reduces.At this regulating step Afterwards, from the vapor-gas phase (Damfphase) under regular vapor pressure anhydrous acrylic acid without wait from Daughter effect, without carrying out top polymerization in the presence of noble gas.Initial plasma enhancing sets The thickness of given layer is 20-30nm, i.e. be about the millesimal magnitude of whole layer thickness.Due to strong hydrophilicity Property, this layer has optics and physiological excellent properties.The layer applied contact angle in water is less than 10 °, it is typically 2 °-5 °.Useful shape effects according to the present invention is processed by this material and is supported.
Fig. 4 shows the flow chart of the method according to the invention.Initially, female mold, positive mold are set, and And the precursor material that will be used for polydimethylsiloxane (dimethyl siloxane) introduces in female molds, and with positive Property mold component close, and between 15 DEG C to 160 DEG C at a temperature of be polymerized 12 to 720 minutes.Step S1 (molding).After closing, mold component is rotated relative to one another 180 ° or another sufficiently large angle (> 20 °), As long as reactant mixture is the most tacky (more than 1000cP；Typically about 4000cP) so that excess Silicones is by reliable separation and is displaced in the annular space between mold component.In separating at this, due to surface Energy effect and produce above-mentioned periphery contour, this allows to avoid edge cuts operation or other can produce cut edge Edge treated (such as punching press).For the demoulding, with alkane or the another kind of nonpolar or little pole of such as hexane Property solvent makes contact lens demi-inflation (step S3), thus makes contact lens from mould without mechanical action (step S5) is departed from tool and manufacture parts.To this end, the dipole moment of solvent for use should not be more than 0.2 debye. As support, it is also possible to use ultra sonic bath.Original material can be that the DK value manufactured by NuSil is higher than 700 The liquid bi-component silicon resin of Barrer.If it is required, then after solvent is evaporated in vacuo in coating room Transmit eyeglass, and first pass through argon ion and eyeglass is carried out (about 1 minute) clean and prepare.Then, rank Section S7 presents the slight excess of 1:1 to 2:1 (intrinsic standoff ratio), latter of which along with argon relative to acrylic acid steam Obtain from anhydrous acrylic acid.The exemplary pressure of argon is 0.03 torr and acrylic acid exemplary pressure is for for 0.015 Torr.This stage needs 10 to 90 minutes, and about 10 minute stage after which is then in airtight argon supply Descend and reduce acrylate pressure (about 0.1 millitorr) further.Then, closedown plasma generator, and Eyeglass is exposed under acrylic acid saturation pressure under room temperature, until turbidity indicates this process and completes (about 5 points Clock).Contact lens is immersed in hydrophilic liquid (in the most isotonic saline solution) 24 hours potential to remove Residual coating agent, and with the temperature higher than 120 DEG C to its steam sterilization.
Showing double part mold in Fig. 5, it is adapted for carrying out said method.The female part 10 of lower section is initial Accommodate reactant mixture, and male part 12 with top closes subsequently, is wherein filled with reactant mixture Space 11 is maintained at therebetween.Lower component 10 have can promote mold component 10 and 12 be entrenched togather with And the inclined-plane 13 ' separated, 13 ".Annular space is denoted as reference 14.
Starting from method, the scrambling in outside result in outside and deviates within certain limits and justify accurately Shape line rather than as known, deviates from punching press eyeglass profile.Similarly, since cornea never has The profile of precise specifications, is therefore not only not harmful with the deviation of ideal form, has wearing comfort on the contrary There is beneficial effect.Add the standard of sum according to minimum deflection square, be computed, divided by the projection of periphery laterally Join preferable sub-circular line to quantify the amount of scrambling.Mean square deviation is as the tolerance of scrambling, and extremely It is 5000 μm less2(be converted into amplitude: about the 1% of optic diameter half), but may be greater than in an embodiment 1000μm2Or more than 10000 μm2。
The contact lens formed according to the present invention can serve as cover type eyeglass, i.e. with or without being used for Physical protection cornea avoids the cover type eyeglass of the refracting power stimulated.This is as Drug therapy formula eye The auxiliary (flanking) (itself being non-therapeutic measure) for the treatment of is useful.
In accompanying claims, " main component " is interpreted as mass ratio more than 50%, particularly relates to 90% Above or even all.In each case, " curvature " is falling of radius of curvature (that is, the radius of approximate circle) Number, wherein the symbol of convex surface be just concave surface be then negative.Gaussian surface curvature is the product of two principal curvatures, Thus, when two principal curvatures have distinct symbols (saddle surface), then Gaussian surface curvature is negative, and when one Individual or two principal curvatures be zero (such as, cylinder and conical surface) Shi Zeqi be zero.
It would be recognized by those skilled in the art that in the case of without departing substantially from the protection domain of claims, can So that above-described embodiment is converted.

Claims (7)

1. the method manufacturing silicones contact lens, wherein, it is provided that female molds parts and male mold Parts, and silicones precursor material is incorporated between described mold component and is polymerized wherein,
It is characterized in that,
The liquid that use can make described contact lens expand makes the contact lens being polymerized from described mould Depart from, and complete described contact lens with not producing cut edge, and subsequently by combination type PECVD/CVD Process makes its hydrophiling.
Method the most according to claim 1, wherein, described contact lens is coated with the (first of crosslinking Base) acrylic acid units.
Method the most according to claim 1 and 2, wherein, described combination type PECVD/CVD process The first coating step occurred by low pressure plasma.
Method the most according to claim 3, wherein, after described combination type PECVD/CVD processes Continuous coating step occurs under conditions of without action of plasma in the gas phase.
5. according to the method according to any one of claim 1,2,4, wherein, use dipole moment less than 0.2 The nonpolar liquid of debye makes described contact lens depart from from described mould.
6. according to the method according to any one of claim 1,2,4, wherein, applicatory being applied with After coating, process, by the polar liquid of dipole moment especially greater than 1 debye, the contact lens detached.
7., according to the method according to any one of claim 1,2,4, wherein, at reactant mixture it is still While liquid, said two mold component is relative to each other rotated, thus reactant mixture is used for shape The part becoming described contact lens separates from the material of excess.
CN201380018315.2A 2012-02-01 2013-02-01 Contact lens Expired - Fee Related CN104204863B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12000649.9 2012-02-01
EP12000649.9A EP2613180B1 (en) 2012-02-01 2012-02-01 Silicon contact lens
PCT/EP2013/000323 WO2013083855A1 (en) 2012-02-01 2013-02-01 Contact lens

Publications (2)

Publication Number Publication Date
CN104204863A CN104204863A (en) 2014-12-10
CN104204863B true CN104204863B (en) 2016-08-17

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CN201380018315.2A Expired - Fee Related CN104204863B (en) 2012-02-01 2013-02-01 Contact lens

Country Status (13)

Country Link
US (1) US20150036100A1 (en)
EP (3) EP2613180B1 (en)
JP (2) JP2014510946A (en)
KR (1) KR20140133830A (en)
CN (1) CN104204863B (en)
AU (1) AU2013206388B2 (en)
BR (1) BR112013022754A2 (en)
ES (2) ES2474572T3 (en)
IN (1) IN2014DN07222A (en)
PL (1) PL2613180T3 (en)
RU (1) RU2014135280A (en)
SG (1) SG11201404482PA (en)
WO (1) WO2013083855A1 (en)

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WO2015096875A1 (en) 2013-12-27 2015-07-02 Lenswista Ag Method of coating lens surfaces
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CA3019627C (en) 2016-04-20 2019-12-31 Coopervision International Holding Company, Lp Silicone elastomer-silicone hydrogel hybrid contact lenses
WO2022224717A1 (en) * 2021-04-19 2022-10-27 国立研究開発法人物質・材料研究機構 Soft ophthalmic lens and method for manufacturing same

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IN2014DN07222A (en) 2015-04-24
JP5913430B2 (en) 2016-04-27
SG11201404482PA (en) 2014-10-30
PL2613180T3 (en) 2014-11-28
EP2810107A1 (en) 2014-12-10
RU2014135280A (en) 2016-03-20
JP2014186340A (en) 2014-10-02
AU2013206388B2 (en) 2015-08-27
ES2474572T3 (en) 2014-07-09
WO2013083855A1 (en) 2013-06-13
EP2613180B1 (en) 2014-03-26
EP2985638A1 (en) 2016-02-17
CN104204863A (en) 2014-12-10
KR20140133830A (en) 2014-11-20
AU2013206388A1 (en) 2014-09-04
BR112013022754A2 (en) 2020-08-04
ES2659021T3 (en) 2018-03-13
EP2985638B1 (en) 2018-01-10
US20150036100A1 (en) 2015-02-05
JP2014510946A (en) 2014-05-01
EP2613180A1 (en) 2013-07-10

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