CN104360495B - The photochromic ophthalmic system of the specific blue light wavelength of selective filter - Google Patents

Abstract

The present invention relates to the photochromic ophthalmic system of the specific blue light wavelength of a kind of selective filter.Providing ophthalmic system, it includes photochromic parts and blue light stop member.

Description

The photochromic ophthalmic system of the specific blue light wavelength of selective filter

Division is stated

The application is filing date on March 25th, 2010, invention entitled " selective filter is specific The photochromic ophthalmic system of blue light wavelength ", the middle promulgated by the State Council of Application No.: 201080022639.X The divisional application of bright patent application.

To Cross-Reference to Related Applications

This application claims in the power of U.S. Provisional Application 61/163,227 that on March 25th, 2009 submits to Benefit.The application is also the portion of the U.S. Patent application 11/933,069 in submission on October 31st, 2007 Tap is continuous, and this U.S. Patent application 11/933,069 is special in the U.S. of submission on June 12nd, 2007 The part of profit application 11/761,892 continues, and this U.S. Patent application 11/761,892 is at 2006 3 The part of the U.S. Patent application 11/378,317 that the moon 20 was submitted to continues, and requires in 2006 The priority of the U.S. Provisional Application 60/812,628 that June 12 submitted to.U.S. Patent application 11/933,069 is also the portion of the U.S. Patent application 11/892,460 in submission on August 23rd, 2007 Tap is continuous, and this U.S. Patent application 11/933,069 requires in the U.S. that on August 23rd, 2006 submits to Provisional application 60/839,432, the U.S. Provisional Application 60/841,502 submitted to for 1st JIUYUE in 2006 Priority with the U.S. Provisional Application 60/861,247 submitted on November 28th, 2006.The U.S. is special Profit application 11/933,069 also requires that at the U.S. Provisional Application that on October 8th, 2007 submits to The priority of 60/978,175.All these applications are incorporated herein by reference in.

Background technology

The air of the earth is bombarded in electromagnetic radiation from the sun constantly.Light is by the electricity propagated with ripple Magnetic radiation is constituted.Electromagnetic spectrum includes radio wave, millimeter wave, microwave, infrared ray, visible Light, ultraviolet (UVA and UVB), x-ray and gamma ray.Visible light spectrum includes about The longest visible wavelength of 700nm and about 400nm (nanometer or 10^-9Rice) the shortest visible ray Wavelength.Blue light wavelength falls in the range of about 400nm to 500nm.For ultraviolet frequency band, UVB wavelength is from 290nm to 320nm, and UVA wavelength is from 320nm to 400nm. Gamma and x-ray constitute the upper frequency of this frequency spectrum, and by Atmospheric Absorption.Ultraviolet radiation (UVR) wavelength spectrum is 100-400nm.Most of UVR wavelength by Atmospheric Absorption, except There is the place in the region in stratospheric ozone cavity.In past 20 years, have recorded main Cavity due to the ozone layer that industrial pollution causes.It is exposed to UVR more and more to have extensively Publilc health impact, as it is expected that have increasing UVR eyes and the burden of dermatosis.

Ozone layer absorbs the wavelength of up to 286nm, and therefore avoiding biology to be exposed to, have can The radiation of amount.But, we are exposed to the wavelength more than 286nm, mostly scolding of this wavelength In the visible spectrum (400-700nm) of people.The retina of people only in response to electromagnetic spectrum can See light part.Shorter wavelength causes the danger of maximum, because they comprise more energy on the contrary Amount.Blue light has shown that it is retinal pigment epithelium (the retinal pigment for animal Epithelium) (RPE) cell produces the part of the visible spectrum that maximum photochemistry is damaged. Exposure for these wavelength has been referred to as blue light harm, because these wavelength are perceived by the human eye For blueness.

Cataract and degeneration of macula are widely believed that to be originated from for intraocular lens and retina Photochemistry infringement.Have shown that blue light exposes and accelerate uveal (uveal Melanoma) propagation of cell.The photon of energy maximum in the visible spectrum has 380 Hes Wavelength between 500nm, and it is perceived as purple or blueness.All mechanism amount to The wavelength dependency of phototoxicity (phototoxicity) is often denoted as action spectrum, such as exists Described below: Mainster and Sparrow was at the Br.J.Ophthalmol volume 87 of 2003 1523-29 page " IOL should transmission how many blue lights？(How Much Blue Light Should an IOL Transmit？) " and Fig. 6.There is no artificial lenticular eyes (aphakia (aphakic) eyes) in, the light with the wavelength shorter than 400nm can cause infringement.? In Phakic (phakic) eyes, this light is absorbed by intraocular lens, does not the most promote Retinal phototoxicity；But, it can cause lenticular optical degeneration or cataract.

The pupil of eyes in response to the suitable light retinal illuminance measured with troland (torland), It is the amphiblestroid incident flux with the relevant sensitivity of wavelength and the projected area of pupil Product.Describe hereinafter this sensitivity: the Wiley company nineteen eighty-two in New York publishes 《Color Science:Concepts and Methods.Quantitative Data and Formulae》 (Wyszecki and Stiles work) 102-107 page.

Following premise is supported in current research forcefully: have about 400nm 500nm's The short-wavelength visible light (blue light) of wavelength can be AMD (age-related macular degeneration) The cause worked.Think the region that the top level of blue light absorption occurs in around 430nm, Such as 400nm 460nm.Research display further, blue light is degrading other in AMD Paathogenic factor, such as heredity, tobacco smoke and excessive consumption of alcohol.

The retina of people includes multilamellar.To be exposed to the light of any entrance eyes the earliest to the deepest These layers that order is listed include:

1) nerve fibre layer

2) ganglionic cell

3) inner plexiform layer (Inner Plexiform Layer)

4) bipolar and horizontal cell

5) outer plexiform layer (Outer Plexiform Layer)

6) photoreceptors (retinal rod (Rod) and the cone (Cone))

7) retinal pigment epithelium (RPE)

8) Bruch's membrane (Bruch's Membrane)

9) choroid (Choroid)

When light by eyes photoreceptor cell，photosensory cell (retinal rod and the cone) absorb time, this cell bleaching and Become to react unhappy until they recover.This recovery process is metabolic processes, and quilt It is referred to as " visual cycle (visual cycle) ".The absorption of blue light has shown that and has reversed this prematurely Individual process.This reverses too early the risk adding oxidative damage, and thinks and cause at view Chromogenesis lipofuscin (lipofuscin) in film.This produces present retinal pigment epithelium (RPE) in layer.Think and be referred to as drusen (drusen) owing to excessive amounts of lipofuscin results in The gathering of extracellular matrix.

Current research instruction, in the life process of the people started with the process of baby, Due to light with amphiblestroid alternately, metabolic waste by-product accumulate at amphiblestroid pigment epithelium layer In.This metabolic waste product is characterized by specific fluorogen, and one of the most significant is lipofuscin Component A2E.The in vitro study that Sparrow is carried out indicates the lipofuscin chromophore found in RPE (chromophore) A2E is by maximum the stimulating of light of 430nm.In theory, when following Time reaches critical point: the combination of the accumulation of this metabolic waste (particularly lipofuscin fluorogen) Reached specific accumulation level, when a people reaches specific age threshold human body The physiological potency of the specific this refuse of retina intracellular metabolite has weakened, and suitable wavelength Blue light stimulates and causes formation drusen in RPE layer.Think that then drusen disturbs permission suitable Nutrient arrives the normal physiological/metabolism behavior of photoreceptors, therefore facilitates age-related macula lutea Degeneration (AMD).It is irreversible serious visual sensitivity in the U.S. and the Western countries AMD The main cause lost.AMD bears it is contemplated that greatly increase in later 20 years, because Design population is flowed and in aged individual quantitative overall increase.

Drusen hinders or stops that RPE layer provides suitable nutrient to photoreceptors, and this causes this The infringement or even dead of a little cells.Seeming when lipofuscin absorbs blue light in large quantities, it becomes Obtain poisonous, cause the further infringement of RPE cell or even dead so that this process enters one Step complicates.Think that lipofuscin component A2E is responsible for the short wavelength sensitive of RPE cell at least in part Degree.A2E has shown that maximally to be stimulated by blue light；The photochemistry event caused from such stimulation Can result in cell death.For example, see in the J.Cataract Refract.Surg of 2004 the 30th Roll up written " the external blue light absorption intraocular implants of Janet R, Sparrow et al. in the 873-78 page Body and retinal pigment epithelium protection (Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro)》。

From the point of view of theory, lower part may appear to occur:

1) start to run through life from baby, Waste buildup occurs in pigment epithelial level.

2) the retinal metabolism behavior of this refuse and ability are processed generally along with the age weakens.

3) speckle pigment generally reduces with people's age, therefore filters less blue light.

4) blue light makes lipofuscin become poisonous.The toxicity damage pigment epithelium cell that result causes.

Illumination and vision care industry are related to people's vision and are exposed to the mark of UVA and UVB radiation Accurate.It is surprising that there is not the such standard about blue light.Such as, now may be used In the Common fluorescent fluorescent tube obtained, glass shell blocks most of ultraviolet, but blue light with Little decay transmission.In some cases, shell is designed in the blue region of frequency spectrum There is the absorbance of enhancing.The harm of such artificial light source is likely to cause eye damage.

The Laboratory evidence that Sparrow obtains in Columbia University has shown that if be blocked in About 50% of blue light in the wave-length coverage of 430 ± 30nm, then the RPE cell caused by blue light The dead height that may reduce is to 80%.Such as, United States Patent (USP) No.6 of Pratt is being authorized, in 955,430 Disclose block blue light to attempt to improve the outside eye wear product of eye health, such as sunglasses, Glasses (spectacles), protective eye lens and contact lens.Purpose is that protection retina is from this Other Ophthalmoligic instruments of phototoxicity light include intra-ocular lens and contact lens.These Ophthalmoligic instruments It is located in the light path between ambient light and retina, and generally comprises or coated selectivity Ground absorbs blue light and the dyestuff of purple light.

The other lenses attempting to be reduced aberration by block blue light is known.Aberration is by eye The optical dispersion of medium causes, and this medium includes cornea, intra-ocular lens, aqueous humour and glass Glass shape liquid.Blue light is focused on the plane of delineation different from the light with longer wavelength by this dispersion Place, causes defocusing of full-colour image.Authorizing United States Patent (USP) No.6,158,862 of Patel etc., awarding Give United States Patent (USP) No.5,662,707 of Jinkerson, authorize United States Patent (USP) No. of Johansen 5,400,175 and authorize in United States Patent (USP) No.4,878,748 of Johansen and describe traditional resistance The lens of gear blue light.

The traditional method exposed for reducing the blue light of a medium is normally completely blocked at threshold value ripple Light under length, also reduces the light in longer wavelength simultaneously and exposes.Such as, U.S. of Partt is being authorized Lens transmission described in state's patent No.6,955,430 less than 40% at the ripple up to 650nm Long incident illumination, as shown in the Fig. 6 in the 430 of Partt.In United States Patent (USP) No.5,400,175 By blue-light blocking lens disclosed in Johansen and Diffendaffer (blue-blocking lens) class As decay light more than 60% in the visible spectrum, as shown in Fig. 3 of 175 patents.

It is likely difficult to balance scope and the quantity of the blue light being blocked, because stopping and/or suppression indigo plant Light affects color balance, people is watched by Optical devices colour vision and the optics dress perceived Color in putting.Such as, shooting glasses looks like jonquilleous, and block blue light.Penetrate Hit glasses often such that some color becomes more apparent upon when a people watches blue sky, it is allowed to shooting Person sees the object that will aim at more accurately.Although this is for shooting glasses function well, but Be it for many ophthalmic applications it is unacceptable.Specifically, such ophthalmic system (ophthalmic system) probably due to due to blue light stop cause in lens produce Huang Color or amber and be aesthetically unappealing.More specifically, stop for blue light one Plant common technique and be directed to use with such as BPI Filter Vision 450 or BPI Diamond Dye The blue light of 500 stops that color (blue blocking tint) is by lens coloring or dyeing.Can such as pass through Lens are immersed in comprise blue light stop dye solution heating color tank in continue that certain is predetermined Time period completes this coloring.Generally, dye solution has yellow or amber, therefore to thoroughly Mirror applies yellow or amber.For many people, this yellow or amber outward appearance can Can be aesthetically less desirable.And, this color may interfere with the normal color sense of lens user Know so that be such as difficult to correctly perception traffic lights or the color of labelling.

Carry out making great efforts to compensate conventional blu-ray and stopped the flavescence effect of filter lens.Such as, Through using such as blue, red or green colouring material other dyestuff to process blue-light blocking lens, To offset flavescence effect.This process makes this other dyestuff become and the stop of original blue light Dyestuff mixes.But, although this technology is likely to reduced the yellow in blue-light blocking lens, But the mixing of dyestuff may by allow more blue spectrum by and reduce blue light stop effect Really.And, these conventional arts reduce the optical wavelength in addition to blue light wavelength undesirably Overall absorbance.This less desirable reduction may cause the vision reducing lens user then Sensitivity.

Having been found that traditional blue light stops and reduce transmission of visible light, this stimulates pupil then The expansion in hole.The expansion of pupil adds and includes intra-ocular lens and amphiblestroid internal eyes The luminous flux of structure.Because for these structures radiant flux with pupil diameter square and increase Greatly, so stopping that the lens of half blue light have the transmission of visible light of reduction, on the contrary by pupil Diameter relax to 3mm from 2mm, actually blue photons is added for amphiblestroid dosage 12.5%.This light that protection retina depends on from phototoxic light clashing on the retina Amount, this amount depends on the transmission properties of a medium and also depends on the dynamic aperture of pupil.So far Modern Previous work is sluggish in the pupil contribution for the prevention of phototoxic blue light.

Another problem that conventional blu-ray stops is that it can reduce Infravision.Blue light is for micro- Lighting level or scotopic vision (scotopic vision) are compared to light or vision improvement (photopic vision) More important, this is to express quantitatively in for the luminous sensitivity spectrum of scotopic vision or vision improvement Result.Photochemistry and oxidation reaction cause IOL soma for the light of 400 to 450nm Absorb along with the age increases naturally.Although the retinal rod being responsible for scotopic vision on the retina is photosensitive The quantity of device reduced also with the age, but the absorption of the increase of intra-ocular lens is for reducing night It is important depending on ability.Such as, scotopic vision sensitivity reduces in the intra-ocular lens of 53 years old 33%, and at 75 years old, crystalline lens reduces 75%.Discussed further below at view Contradiction between film protection and scotopic vision sensitivity: Mainster and Sparrow was at the Br.J. of 2003 Ophthalmol volume 87 1523-29 page " IOL should transmission how many blue lights？(How Much Blue Light Should an IOL Transmit？)》.

The traditional means that blue light stops can also include cut-off or high pass filter lens, for will be for The blue light specified or the absorbance of violet wavelength are reduced to 0.For example, it is possible to completely or almost completely Ground stops all light under threshold wave-length.Such as, U.S. published patent application No. 2005/0243272 to Mainster and Mainster in the Arch.Ophthal of 2005 volume 123 Page 550 " intraocular lens should stop UV radiation and purple light rather than blue light (Intraocular Lenses Should Block UV Radiation and Violet but not Blue Light) " describe Light under stop all threshold wave-length between 400 and 450nm.Such stop may It is less desirable, because when longer wavelength is shifted at the edge of long pass filter mirror, the expansion of pupil The effect of opening increases total flux.As it has been described above, this so that scotopic vision deterioration of sensitivity also And increase cross-color.

Recently, the field of crystalline lens (IOL) the most within the eye exists about keeping acceptable Vision improvement, scotopic vision, colour vision and physiological rhythm while begging for of stopping of suitable UV and blue light Opinion.

In view of the foregoing, need to provide one or more ophthalmic system of following part:

1) blue light with acceptable blue light level of protection stops

2) acceptable color aesthetic feeling, i.e. ophthalmic system is observed eye when being worn by wearer Someone of section's system is perceived as substantially muted color.

3) color-aware acceptable for user.In particular, it may be desired to a kind of ophthalmic system, It does not damage the colour vision of wearer, and further from the eyes of the rear surface of system to wearer Interior reflection is in the level do not disliked by wearer.

4) for the acceptable level of light transmission of wavelength in addition to blue light wavelength.Tool Saying, needing a kind of ophthalmic system, it allows the wavelength of optionally block blue light body, and The visible ray more than 80% of the transmission simultaneously.

5) acceptable vision improvement, scotopic vision, colour vision and/or physiological rhythm (circadian rhythms)。

This needs exists because increasing data pointing to as degeneration of macula ( Blind main cause in industrialised world) and other retinal diseasess in may cause a disease because of The blue light of one of element.

Summary of the invention

Provide ophthalmic system, it include photochromic parts (photochromic component) and Blue light stop member.

In one embodiment, a kind of ophthalmic system includes at least one blue light stop member (blue-blocking component) and at least one photochromic parts (photochromic Component), wherein, described blue light stop member filters continuously and optionally and is included in greatly The blue light wavelength range of choice of the wavelength of about 430nm, and wherein, described photochromic parts work as quilt During activation, filtration is included in the visible ray of the wavelength outside the described blue light wavelength range of choice.

In one embodiment, at visible ray in the system (activated system) of described activation Ratio is or not average transmittance (average transmission across the visible spectrum) in spectrum Average transmittance little at least 20% on visible spectrum in active system (inactive system).

In another embodiment, the blue light wavelength range of choice flat described in the system activated All absorbance is less than the average transmittance of the blue light wavelength range of choice described in sluggish system.

In another embodiment, the blue light wavelength range of choice flat described in the system activated All absorbancies are the average transmittance of the blue light wavelength range of choice described in sluggish system In 20% or in 5%.

In one embodiment, described blue light stop member is not photochromic.

In one embodiment, described blue light stop member optionally filters at described blue light ripple At least 20% or at least 50% of light in the long range of choice.

In one embodiment, the described blue light wavelength range of choice includes from about 420nm to greatly About 440nm, from about 410nm to about 450nm or from about 400nm to about 460nm Wavelength.

In another embodiment, described system farther includes the most extra blue light stop part Part, its optionally wavelength-filtered range of choice, this wavelength range of choice includes in addition to A2E Chromophore.

In yet another embodiment, described system by contrast sensitivity at sinusoidal wave grating test (sine wave grating test) (such as, FACT^TM1 point is increased at least 1 on).

In another embodiment, system that is described inactive and/or that activate has less than 8 or little Yellow colour index (yellowness index) in 5.

In one embodiment, white light has when being transmitted through the system of inactive and/or activation CIE (x, y) coordinate of (0.33 ± 0.05,0.33 ± 0.05).

In one embodiment, described blue light stop member include perylene (perylene), Porphyrin (porphyrin), coumarin (coumarin), acridine (acridine) and spread out Biological.In certain embodiments, described blue light stop member include perylene or derivatives thereof, Porphyrin or derivatives thereof or fourBase porphyrin magnesium (magnesium tetramesitylporphyrin).

In another embodiment, described blue light stop member includes that concentration is of about 1ppm to greatly About 50ppm or about 2ppm stop dyestuff to the blue light of about 10ppm.

In one embodiment, described photochromic parts by UVB, UVA, blue light, visible ray and At least one of Infrared wavelength activates.In another embodiment, by UVB, UVA and At least one of Infrared wavelength activates described photochromic parts.In yet another embodiment, institute State photochromic parts and be there is the about 380nm photoactivation to the wavelength of about 410nm.

In one embodiment, described system farther includes UV filter lens.An embodiment In, after described UV filter lens is positioned at described photochromic parts.In another embodiment, described The wavelength activating described photochromic parts is not filled into and stops the degree activated by UV filter mirror.

In one embodiment, described system is ophthalmic lens (ophthalmic lens), glasses Lens (spectacle lens), contact lens (contact lens), intraocular lens (intra-ocular Lens), corneal inlay (corneal inlay), cornea cover (corneal onlay), cornea Graft (corneal graft), electro-active lens (electro-active lens), windscreen Or window (window) (windshield).In one embodiment, described system is that glasses are saturating Mirror.

In one embodiment, at least one of described photochromic parts and described blue light stop member It is present in described system.In another embodiment, described photochromic parts and described blue light At least one of stop member is positioned at the local in described system.

In one embodiment, described blue light stop member includes blue light barrier layer, and/or Described photochromic parts include light chromatograph.

In one embodiment, described blue light stop member is before described photochromic parts.Separately In one embodiment, described blue light stop member is after described photochromic parts.An enforcement In example, described blue light stop member not with described photochromic component physical contact.Real at another Execute in example, described blue light stop member and the mixing of described photochromic parts.

Accompanying drawing explanation

Figure 1A and 1B illustrates and includes posterior blue light stop member and preceding color balance parts The example of ophthalmic system.

Fig. 2 is shown with resistant (dye resist) and forms the example of ophthalmic system.

Fig. 3 illustrates blue light stop member and color balance parts are incorporated into transparent (clear) or substantially The transparent example system in ophthalmic lens.

Fig. 4 illustrates the exemplary ophthalmic system using in-mold coating (in-mold coating) to be formed.

Fig. 5 illustrates the combination (bonding) of two ophthalmic components.

Fig. 6 illustrates the exemplary ophthalmic system using anti-reflection coating.

Fig. 7 A-7C diagram blue light stop member, color balance parts and the various examples of photochromic parts Property combination.

Fig. 8 A and 8B illustrates and includes that multi-functional blue light stops and the ophthalmic system of color balance parts Example.

Fig. 9 illustrates the reference of the color of the observation corresponding with various CIE coordinates.

Figure 10 illustrates that GENTEX E465 absorbs the absorbance of dyestuff.

Figure 11 illustrates that GENTEX E465 absorbs the absorbance of dyestuff.

Figure 12 illustrates the Merlon with the dye strength being suitable in 430nm scope absorption The absorbance of substrate.

Figure 13 is shown as having the saturating of the function of the wavelength of the polycarbonate substrate of anti-reflection coating Penetrate rate.

Figure 14 illustrates the color diagram of the polycarbonate substrate with anti-reflection coating.

Figure 15 is shown as Merlon (polycarbonate) substrate of uncoated and at two tables There is on face the absorbance of the function of the wavelength of the polycarbonate substrate of anti-reflection coating.

The spectral-transmission favtor of the TiO2 layer of the 106nm that Figure 16 is shown on polycarbonate substrate.

The color diagram of the TiO2 layer of the 106nm that Figure 17 is shown on polycarbonate substrate.

The spectral-transmission favtor of the TiO2 layer of the 134nm that Figure 18 is shown on polycarbonate substrate.

The color diagram of the TiO2 layer of the 134nm that Figure 19 is shown on polycarbonate substrate.

Figure 20 illustrates the amendment that is suitable for the substrate color balance with blue-absorbing dye The spectral-transmission favtor of AR coating.

Figure 21 illustrates the amendment that is suitable for the substrate color balance with blue-absorbing dye The color diagram of AR coating.

Figure 22 illustrates the spectral-transmission favtor of the substrate with blue light absorption dyestuff.

Figure 23 illustrates the color diagram of the substrate with blue light absorption dyestuff.

Figure 24 illustrates the spectral-transmission favtor of the substrate with blue light absorption dyestuff and rear AR coating.

Figure 25 illustrates the color diagram of the substrate with blue light absorption dyestuff and rear AR coating.

Figure 26 illustrates the substrate with blue light absorption dyestuff and the AR coating in front and rear surfaces Spectral-transmission favtor.

Figure 27 illustrates the substrate with blue light absorption dyestuff and the AR coating in front and rear surfaces Color diagram.

Figure 28 illustrates that the spectrum of the substrate with blue light absorption dyestuff and color balance AR coating is saturating Penetrate rate.

Figure 29 illustrates the color diagram of the substrate with blue light absorption dyestuff and color balance AR coating.

Figure 30 illustrates the exemplary ophthalmic device including film.

Figure 31 illustrates the optical transmittance characteristic of exemplary film.

Figure 32 illustrates the exemplary ophthalmic system including film.

Figure 33 illustrates the example system including film.

Figure 34 A and B is shown respectively pupil diameter and the pupil area of the function as field illumination.

Figure 35 illustrates the transmission spectrum of the film of doping perylene dyes, wherein, concentration and path length The product of degree obtains the absorbance of about 33% at about 437nm.

Figure 36 illustrates the transmission spectrum of the film according to the present invention, and wherein, Perylene concentrations is previous About 2.27 times illustrated in individual figure.

Figure 37 illustrates for SiO₂And ZrO₂The folded exemplary transmission spectrum of six layer stack.

Figure 38 illustrates and the Meng Saier illuminated by the luminous body of regulation in (L*, a*, b*) color space The reference color coordinates that tile (Munsell tiles) is corresponding.

Figure 39 A illustrates the rectangular histogram of the gamut of the Meng Saier color tile for relevant filter mirror. Figure 39 B illustrates and is stopped, by the blue light being correlated with, the gamut that filter mirror causes.

Figure 40 illustrates the rectangular histogram of the gamut for perylene dyes substrate according to the present invention.

Figure 41 illustrates the transmission spectrum of the system according to the present invention.

Figure 42 illustrates and collects for Meng Saier tile in the sunlight according to the face of assembly of the invention The rectangular histogram of colour distortion.

Figure 43 A and B illustrates representational a series of skin reflexs of the object from different nationalities Spectrum.

Figure 44 illustrates the exemplary skin reflectance spectrum of Caucasia object.

Figure 45 illustrates the transmission spectrum for various lens.

Figure 46 illustrates exemplary dyes.

Figure 47 illustrates the ophthalmic system with hard conating.

Figure 48 is shown as the wavelength selecting filter lens with the strong absorption band around 430nm The absorbance of function.

Detailed description of the invention

Embodiments of the invention relate to a kind of ophthalmic system, and it performs effective blue light and stops, and And it is simultaneously provided in the most attractive product, color normal or acceptable for user Perception and the high-caliber transmission light for good visual sensitivity.Provide a kind of ophthalmology system System, it can provide the average transmittance of 80% of visible ray or more preferable absorbance, selectively Suppression blue light wavelength (" blue light stops (blue blocking) "), it is allowed to wearer's is correct Colour vision shows, and wears the observer of the wearer of such lens or lens combination to viewing The outward appearance of muted color the most is provided.As used herein, the " average transmittance (average of system Transmission) average transmittance of wavelength in the scope of such as visible spectrum " is referred to. System can also be characterized by " luminous transmittance (the luminous transmission) " of system, system " luminous transmittance " refer to the meansigma methods in wave-length coverage, its according to eyes at each ripple The sensitivity of strong point is weighted.System described herein can use various optical coating, Film, material and absorption dyestuff produce intended effect.

More specifically, embodiments of the invention can provide the effective indigo plant with color balance combination Light blocking." color balance (Color balancing) " as used herein or " color is balanced (color Balanced) " represent yellow or amber or other blue lights are stopped that unwanted effect drops Low, skew, neutralization or compensation, to produce in the most acceptable result, are not dropped simultaneously The effect that low blue light stops.Such as, at 400nm 460nm or near wavelength permissible It is blocked or reduces intensity.Especially, such as, at 420 440nm or near wavelength Can be blocked or reduce intensity.And, the absorbance of the wavelength not stopped may remain in height Level, such as at least 80%.It addition, for outside spectators, ophthalmic system is it may appear that thoroughly Bright or substantial transparent.For system user, color-aware can be normal or acceptable.

" ophthalmic system (ophthalmic system) " as used herein include such as transparent or The eyeglass (or glasses) of coloring, sunglasses, with and without visual and/or aesthetic feeling coloring Contact lens, intraocular lens (IOL), corneal graft, corneal inlay, cornea cover and The prescription of electrical activation Ophthalmoligic instrument or the ophthalmic lens of OTC (over-the-counter), and can processed or process Or combine with miscellaneous part, the desired function further described at this with offer.The present invention Can be formed to allow to be applied directly in cornea tissue.

As used herein, " ophthalmic materials (ophthalmic material) " is typically used for Manufacture the material of the ophthalmic system such as correcting lens (corrective lens).Exemplary ophthalmic material Material includes the plastics of glass, such as CR-39, Trivex and makrolon material, although can also Use other materials, and these other materials are known for various ophthalmic systems.

Ophthalmic system can include one or more blue light stop member.In one embodiment, Blue light stop member is after color balance parts.Blue light stop member or color balance parts can To be the ophthalmic components of such as lens or to form one part.Blue light stop member below and front The color balance parts in face can be on one or more surfaces of ophthalmic lens or adjacent or Neighbouring different layers.There is provided one or more color balance parts to reduce or neutralization below The yellow of blue light stop member or amber colouration, to produce in the most acceptable outward appearance. Such as, for outside spectators, ophthalmic system can seem transparent or substantial transparent.For System user, color-aware can be normal or acceptable.And, because blue light stops Do not mix, so the wavelength in blue spectrum can be blocked or reduce by force with color balance coloring Degree, and the intensity in transmission of the incident illumination in ophthalmic system for the wavelength not stopped can be to Few 80%.

As it has been described above, the technology for blue light stop is known.For block blue light wavelength Known technology includes absorbing, reflects, interferes or its combination in any.As it has been described above, according to one Technology, can in the proper ratio or concentration uses such as BPI Filter Vision 450 or BPI The blue light of Diamond Dye 500 stops that color colours/tinted lenses.Can such as pass through following side Formula completes this coloring: lens are immersed in the color tank comprising the heating that blue light stops dye solution In certain predetermined time period.According to another kind of technology, filter lens is used for blue light and stops.Should Filter lens can include such as presenting and absorbs and/or reflection and/or interference with blue light wavelengths organic Or inorganic compound.Filter lens can include organic and/or multiple thin layers of inorganic substances or coating. Every layer can have individually or absorb in combination with other layers, reflect or interfere and has blue light ripple The attribute of long light.Pectination notch filtering light mirror (Rugate notch filter) is that blue light stops optical filtering One example of mirror.Pectination filter lens is the single thin film of inorganic dielectric, wherein, refractive index Vibrate continuously between height and low value.By bi-material (such as, the SiO of different refractivity₂ And TiO₂) co-deposition and manufacture, pectination filter lens is known have for wavelength blocking good The stopband of definition, and outside this band, have the least decay.The constructing variable of filter lens (shakes Swing the quantity of cycle, index modulation, refractive index oscillation) determine that the performance parameter of filter lens (hinders Band center, the width of stopband, band in absorbance).Such as in United States Patent (USP) No. 6,984,038 and 7, disclose in more detail pectination filter lens in 066,596, each is special to quote this The entirety of profit.The another kind of technology stopped for blue light is the use that multi-layer dielectric stacks.Logical Cross the stratum disjunctum of the staggered high index of refraction of deposition and low-index material to manufacture multi-layer dielectric heap Folded.It is similar to pectination filter lens, the thickness of such as each layer, the refractive index of each layer and layer weight The design parameter of multiple quantity determines the performance parameter that multi-layer dielectric stacks.

Color balance may include that and applies the suitable of the most blue-colored/dyestuff to color balance parts Appropriately combined when ratio or concentration or red and green coloring/dyestuff so that when by external observation When person watches, ophthalmic system entirety has the most acceptable outward appearance.Such as, ophthalmic system Entirety can seem transparent or substantial transparent.

Figure 1A illustrates and includes posterior blue light stop member 101 and preceding color balance parts 102 Ophthalmic system.Each parts includes recessed rear side or surface 110,115 and convex front side or surface 120、125.Within system 100, posterior blue light stop member 101 can be or include ophthalmology Parts, such as single vision lens (single vision lens), wafer or optical preform.Should Single vision lens, wafer or optical preform can be colored or dyed to perform blue light to be stopped. Preceding color balance parts 102 can include surface cast layer (surface cast layer), according to Known technology applies it to single vision lens, wafer or optical preform.For example, it is possible to Use visible ray or UV light or a combination of both to be pasted by this surface cast layer or to be attached to monochromatic light saturating Mirror, wafer or optical preform.

Surface cast layer can be formed on the convex side of single vision lens, wafer or optical preform. Because the coloring of single vision lens, wafer or optical preform or dyeing being hindered to perform blue light Gear, so it is likely to be of in the most less desirable yellow or amber.It is therefoie, for example, The proper proportion of blue-colored/dyeing or red and suitable group of green coloring/dyeing can be used Incompatible colored surface cast layer.

Can be applied to treated make the single vision lens of block blue light, crystalline substance at surface cast layer After sheet or optical preform, it is possible to use color balance additive processes surface cast layer. Such as, have single vision lens that cast layer blue light on their convex surfaces in surface stops, wafer or Optical preform can be immersed in the color tank of heating, and the color tank of this heating has proper proportion With the color balancing dye of concentration in the solution.This surface cast layer absorbs color balance from solution Dyestuff.In order to the single vision lens preventing blue light from stopping, wafer or optical preform absorb color Any one of balancing dye, it is possible to use such as band (tape) or wax or the resist printing of other coatings Its concave surface is sheltered or closed to material.Illustrating this point in fig. 2, Fig. 2 illustrates ophthalmology System 100, within the system, at the recessed table of single vision lens, wafer or optical preform 101 There is on face resistant 201.The edge of single vision lens, wafer or optical preform can stay Under do not apply, to allow them to become in aesthetically adjustable color.This is possibly for having thickness The negative focal length lens (negative focal lenses) at edge is important.

Figure 1B illustrates another kind of ophthalmic system 150, and wherein, preceding color balance parts 104 can To be or to include ophthalmic components, such as single vision lens or multi-focus lens (multi-focal lens), Wafer or optical preform.Posterior blue light stop member 103 can be surface cast layer.For Set up this combination, it is possible to use resistant as above shelters the list of color balance The nonreentrant surface of optical lens, wafer or optical preform, to prevent it to be immersed in bag in this combination Stop that containing blue light the blue light that absorbs when adding in thermocolour tank of dye solution stops dyestuff.Meanwhile, expose Surface cast layer will absorb blue light and stop dyestuff.

It should be understood that surface cast layer can with multi-focus lens (rather than single vision lens), Wafer or optical preform are applied in combination.It addition, surface cast layer may be used for monochromatic light saturating Mirror, wafer or optical preform increase multiplying power (power), including multifocal multiplying power, because of Single vision lens, wafer or optical preform are converted to have what linear or progression type was added by this Multi-focus lens.Certainly, surface cast layer can also be designed to single vision lens, wafer or Optical preform is plus little multiplying power or does not increase multiplying power.

Fig. 3 illustrates that blue light stops and color balance is functionally incorporated in ophthalmic components.More specifically Ground, in ophthalmic lens 300, with region, portion behind at color penetration to transparent or the most saturating The corresponding part 303 of the bright degree of depth in ophthalmic components 301 can be that blue light stops.And, With the color penetration at region, portion before or after it to the transparent or ophthalmic components of substantial transparent Part 302 corresponding to the degree of depth in 301 can be color balance.System shown in figure 3 can With produced by below.Ophthalmic components 301 can be the most initially transparent or the monochromatic light of substantial transparent or Multi-focus lens, wafer or optical preform.Blue light can be used to stop, and color dyes is transparent Or the monochromatic light of substantial transparent or multi-focus lens, wafer or optical preform, simultaneously before it Nonreentrant surface is such as sheltered as described above by use resistant or is applied and is rendered as non-absorbing 's.As a result, it is possible to created at the transparent or monochromatic light of substantial transparent or many by color penetration Start at the thick concave surface of punktal lens, wafer or optical preform 301 and extend internally also And there is the part 303 of blue light barrier functionality.It is then possible to the anti-absorption removing convex front face is coated with Layer.It is then possible to anti-absorber coatings to be applied to concave surface, and monochromatic light or many can be coloured The convex front face of punktal lens, wafer or optical preform and periphery (such as, pass through submergence In the color tank of heating) for color balance.Color balancing dye is by this periphery and part 302 Absorb, part 302 starts in convex front face and extends internally, and due to the initial stage coating and It is left and does not colours.The order of aforementioned processing can invert, i.e. can first shelter concave surface, Remainder is coloured for color balance simultaneously.It is then possible to remove removing coating, and can The degree of depth at uncoloured concave region or thickness will stayed to colour for indigo plant by sheltering Light blocking.

Referring now to Fig. 4, it is possible to use in-mold coating forms ophthalmic system 400.More specifically, The in-mold coating 403 that can use coloring carrys out color balance via surface casting and has used Suitable blue light stops that color, dyestuff or the monochromatic light of other additive dye/tint or multifocal are saturating The ophthalmic components 401 of mirror, wafer or optical preform.Suitable water including color balancing dye Flat and/or mixture in-mold coating 403 can be applied to nonreentrant surface mould (that is, for ophthalmology The nonreentrant surface of parts 401 applies the mould (not shown) of coating 403).Can be at coating 403 and eye Fill between section's parts 401 and solidify colorless monomer (monomer) 402.Curing monomer 402 Process the nonreentrant surface making the in-mold coating of color balance that itself transfer to ophthalmic components 401. Result is that the blue light with color balance face coat stops ophthalmic system.In-mold coating can be with example Anti-reflection coating or traditional hard conating in this way.

Referring now to Fig. 5, ophthalmic system 500 can include two ophthalmic components, and one is blue light Stop member, another is color balance parts.Such as, the first ophthalmic components 501 can be to make Rear monochromatic light or concave surface multi-focus lens, the wafer of colors staining/coloring is stopped with suitable blue light Or optical preform, to realize desired blue light barrier level.Second ophthalmic components 503 is permissible It is such as to use the binding agent 502 of UV or visible light curable to combine or be bonded to rear monochromatic light or recessed The front monochromatic light of surface multi-focus lens, wafer or optical preform or nonreentrant surface multi-focus lens, Wafer or optical preform.Front single vision lens or nonreentrant surface multi-focus lens, wafer or optics Preformed member at it with rear single vision lens or concave surface multi-focus lens, wafer or optics preforming Part can present color balance before or after combining.If afterwards, the most such as by as above Described technology is so that front single vision lens or nonreentrant surface multi-focus lens, wafer or optics are pre- Profiled member is color balance.It is, for example possible to use resistant shelter or apply after monochromatic light Lens or concave surface multifocal lens, wafer or optical preform, to prevent it from absorbing color Balancing dye.It is then possible to combining rear section be placed in together with forward part comprise color put down Weighing apparatus dyestuff suitable solution add in thermocolour tank, with allow forward part absorb color balancing dye.

Any one of above-described embodiment system can be with one or more antireflections (AR) parts Combination.For the ophthalmic lens 100 and 150 shown in Figure 1A and 1B, such as, figure 6 illustrates This point.In figure 6, AR parts 601 of such as coating be applied to rear blue light stop unit The concave surface of part 101, and the 2nd AR parts 602 are applied to the convex table of color balance parts 102 Face.Similarly, AR parts 601 are applied to the concave surface of rear blue light stop member 103, And the 2nd AR parts 602 are applied to the nonreentrant surface of color balance parts 104.

Fig. 7 A-7C illustrates the further example including blue light stop member and color balance parts Sexual system.In fig. 7, ophthalmic system 700 includes blue light stop member 703 and color balance portion Part 704, they are formed on the front surface of the ophthalmic lens 702 of transparent or substantial transparent Or neighbouring adjacent but the coating that is to discriminate between or layer.Blue light stop member 703 is at color balance parts After 704.The rear surface of the ophthalmic lens of transparent or substantial transparent on or near, permissible Form AR coating or other layers 701.Can be on or near the front surface of color balance layer 704 Form another AR coating or layer 705.

In figure 7b, blue light stop member 703 and color balance parts 704 are arranged in transparent or base On or near the rear surface of ophthalmic lens 702 transparent in basis.Again, blue light stop member 703 after color balance parts 704.AR parts 701 can be formed at blue light stop member 703 Rear surface on or near.Another AR parts 705 can be formed at transparent or substantial transparent Ophthalmic lens 702 front surface on or near.

In fig. 7 c, blue light stop member 703 and color balance parts 704 are arranged in transparent On or near the rear surface of ophthalmic lens 702 and front surface.Again, blue light stop member 703 After color balance parts 704.After AR parts 701 can be formed at blue light stop member 703 On or near surface, and another AR parts 705 can be formed at color balance parts 704 Front surface on or near.

Fig. 8 A and 8B illustrates ophthalmic system 800, wherein for block blue light wavelength and execution color The function of balance can combine in single parts 803.Such as, this combined functionality component can hinder Gear blue light wavelength, and also it is reflected back some green and red wavelengths, therefore by blueness neutralization, And eliminate and mass-tone occurs in lens.Combined functionality component 803 can be arranged in transparent eye On or near the front surface of section's lens 802 or rear surface.Ophthalmic lens 800 can wrap further Include the AR parts 801 on or near the front surface or rear surface of transparent ophthalmic lens 802.

Although Fig. 7 and 8 depicts the structure of specific embodiment, but the ordinary skill in this area Personnel are it will be appreciated that the location of blue light stop member and color balance parts can be with material, system Make process and application and different.Such as, blue light stop member can be at such as ophthalmic lens or light Before one or more ophthalmic components of color parts, afterwards with its one or sandwiched therebetween.Class As, color balance parts can before one or more ophthalmic components, afterwards and one Body or sandwiched therebetween.And, blue light stop member can relative to color balance parts changeably Location (although some embodiments specify blue light stop member after color balance parts).

For the effect of quantized color equalizing feature, observe the substrate reflection by ophthalmic materials and/or The light of transmission is probably useful.Observed light can (x, y) coordinate characterizes, to refer to by its CIE Show the color of the light of observation；By these coordinates are made comparisons with the CIE coordinate of incident illumination, permissible Determine owing to reflection/transmission causes offset by the color of how much light.White light is defined as CIE Coordinate (0.33,0.33).Therefore, the CIE coordinate of observed light is closer to (0.33,0.33), then It seems " the whitest " for observer.In order to characterize the gamut or balance performed by lens, By the white light of (0.33,0.33) towards lens, and the CIE of the light of reflection and transmission can be observed. If the light of institute's transmission has about the CIE of (0.33,0.33), then there is no gamut, and by thoroughly The object of mirror viewing has natural outward appearance, i.e. observe relative in the case of not having lens Object, color will not offset.Similarly, if reflection light has about the CIE of (0.33,0.33), Then lens will have natural aesthetic appearance, i.e. it is for viewing lens or the use of ophthalmic system Seem not colour for the observer at family.Therefore, it is desirable to transmission and reflection light have as far as possible CIE close to (0.33,0.33).

Fig. 9 illustrates the CIE diagram for indicating the observation color corresponding with various CIE coordinates.Reference point 900 instructions coordinate (0.33,0.33).Although the middle section of this figure is designated as " white ", but It is that some light with the CIE coordinate in this region may appear to slightly for the audience Color.Such as, the light for observer with CIE coordinate (0.4,0.4) will appear to be yellow 's.Therefore, in order to realize the muted color outward appearance in ophthalmic system, it is desirable to by system transmittance and/ Or reflection (0.33,0.33) light (that is, white light) have after transmission/reflection/angle as close possible to (0.33, 0.33) CIE coordinate.CIE diagram shown in Fig. 9 will be used herein as with reference to be shown with each germline The gamut that overall view observes, but tab area is had been omitted for clarity.

Can be by wrapping in the substrate material of ophthalmic lens in dyestuff is molded into substrate material Include absorption dyestuff, to produce, there are specific light transmission and the lens of absorption properties.Due to generally Finding to there is Soret band (Soret band) in porphyrin material, these dye materials can be inhaled Receive the resonance wavelength of the basic peak wavelength or shorter of dyestuff.Exemplary ophthalmic material includes various Glass and polymer, such asMerlon, poly-methyl methacrylate Ester (polymethylmethacrylate), silicone (silicone) and fluoropolymer (fluoropolymers), but other materials can also be used and for various ophthalmology systems System is known.

The most for example, in the material E465 transmission of GENTEX day shown in Figure 10-11 and absorption. Absorbance (A) is relevant to absorbance (T) by equation A=logio (l/T).In this case, Absorbance (0 < T < 1) between zero and one.Absorbance is usually expressed as percentage ratio, i.e. 0% < T < 100%.E465 dyestuff stop less than 465 those wavelength, and be normally provided for High light intensity (OD > 4) stops these wavelength.Similar product can be obtained to stop other Wavelength.Such as, the E420 from GENTEX stops the wavelength lower than 420nm.Other examples Property dyestuff includes porphyrin, perylene and the similar dyestuff that can absorb blue light wavelength.

The absorbance at shorter wavelength can be reduced by reducing dye strength.This and its He can realize～the absorbance of 50% by dye materials in the region of 430nm.Figure 12 illustrates poly-carbon The absorbance of acid esters substrate, this polycarbonate substrate have be suitable in 430nm region absorb Dye strength and have some to absorb in the scope of 420nm-440nm.By reducing the dense of dyestuff Spend and include that the effect of polycarbonate substrate is to realize this point.Rear surface is not entered at this point Row antireflection applies.

The concentration of dyestuff can affect outward appearance and the gamut of ophthalmic system.By reducing concentration, can To obtain the system of the gamut degree with change." gamut (color shift) " as used herein refers to Be reference light CIE coordinate ophthalmic system transmission and/or reflection after change amount.Can also It is advantageous that due to be generally perceived as white various types of light (such as, sunlight, Incandescent light and fluorescent light) in difference, the gamut caused by system characterizes system. Therefore, it can it is advantageous that based on when system transmittance and/or reflection light time incident illumination CIE coordinate The amount of displacement characterizes system.Such as, wherein there is the light of CIE coordinate of (0.33,0.33) thoroughly The system becoming having the light of the CIE of (0.30,0.30) after penetrating can be described as causing (-.03 ,-.03) Gamut, or more generally, cause the gamut of (± 0.03, ± 0.03).Therefore, by system The gamut instruction light that causes and the object watched for the wearer of system how seem " from So ".As further described below, have been realized in causing less than (± 0.05, ± 0.05) to (± 0.02, ± 0.02) system of gamut.

Minimizing at the short-and-medium wavelength transmission of ophthalmic system can be of value to minimizing due to such as A2E's The cell death that the photoelectric effect in eyes of excitation causes.It has been shown that will be 430 ± 30 The incident illumination of nm reduces about 50% can reduce about 80% by cell death.See, for example 2004 Year J.Cataract Refract.Surg in Janet R, Sparrow etc. in volume 30 the 873-78 page People written " external blue light absorption intraocular lens and retinal pigment epithelium protection (Blue light-absorbing intraocular lens and retinal pigment epithelium protection In vitro) ", comprise the disclosure of which by quoting its entirety.It is further believed that reduce indigo plant The amount 5% of light (the such as light in 430-460nm scope) is so many can be similarly reduced carefully Born of the same parents are dead and/or degeneration, therefore prevent or reduce the situation of senile degeneration of macula of such as atrophy Harmful effect.

Although absorbing dyestuff to may be used for stopping the light of less desirable wavelength, but this dyestuff may In lens, coloring is produced as side effect.Such as, the ophthalmic lens that many blue lights stop has Yellow, this is often less desirable and/or the most beastly.This in order to compensate Color, can include wherein absorbing and apply color on one or two surface of the substrate of dyestuff Balance coating.

Antireflection (AR) coating (they are interference filter) in business ophthalmology coating is in the industry Ripe.Which floor this coating is typically, and often less than 10 layers, and is generally used for autohemagglutination in the future The reflection on carbonic ester surface is reduced to less than 1%.Figure 13 illustrates this at polycarbonate surface On the example of coating.Figure 14 illustrates the color diagram of this coating, and observe, should Color is the most neutral.Observe that total reflectance is 0.21%.Observe that reflection light has CIE and sits Mark (0.234,0.075)；Transmission light has CIE coordinate (0.334,0.336).

AR coating can be applied to two surfaces of lens or other Ophthalmoligic instruments, to obtain more High absorbance.Figure 15 illustrates such structure, wherein, thicker line 1510 is that AR is coated with The Merlon of layer, and thinner line 1520 is the polycarbonate substrate of uncoated.This AR Coating provides the raising of 10% in total transmission light.Due to the suction in polycarbonate substrate Receive, there are some natural loss of light.Specific polycarbonate substrate for this example has The transmission losses of about 3%.At ophthalmology in the industry, AR coating is generally applied to two surfaces, To improve the absorbance of lens.

In a system in accordance with the invention, AR coating or other color balance films can contaminate with absorbing Material combination is to allow to absorb the generally blue wavelength light in 430nm region and raising thoroughly simultaneously Penetrate rate.As it has been described above, the only light in 430nm region eliminates and typically results in that to have some remaining The lens of colour cast (residual color cast).In order to spectrally customize light to realize Color Neutral Transmission, can revise AR coating at least one with adjust light overall transmitted colors.At root According in the ophthalmic system of the present invention, can be performed this for the front surface of lens and adjust, to build Make the lens arrangement in face:

Air (farthest with the eyes of user)/lordosis lens coating/absorptive ophthalmic substrates of lenses/after Recessed anti-reflection coating/air (closest to eyes of user).

In such structure, in addition to the anti-reflective function generally performed in conventional lenses, Front-coating mirror can further provide for the colour cast that spectrum customization causes with the absorption compensated in the substrate. Therefore, lens can be transmission and reflect the color balance that light provides suitable.Feelings at transmission light Under condition, color balance allows correct colour vision；In the case of reflection light, color balance is permissible The lens providing suitable are attractive in appearance.

In some cases, color balance film can be arranged between the two-layer of other ophthalmic materials. For example, it is possible to arrange filter lens, AR film or other films in ophthalmic materials.For example, it is possible to make Configuration with following:

Air (farthest with the eyes of user)/ophthalmic materials/thin film/ophthalmic materials/air (connects most Nearly eyes of user).

Color balance film can also be outer surface and/or the interior surface being applied to lens Coating, such as hard conating.Can also be other structures.Such as, with reference to Fig. 3, ophthalmic system can With the ophthalmic materials 301 including being doped with blue light absorption dyestuff and one or more color balance layer 302、303.In another kind constructs, internal layer 301 can be by being doped with blue light absorption dyestuff Ophthalmic materials 302,303 around color balance layer.Can be at one or more tables of this system Other layer and/or the coating of such as AR coating is arranged on face.It will be appreciated that how can be in example Similar material and structure is used in reference to the system as described in Fig. 4-8B.

Therefore, blooming and/or the coating of such as AR coating may be used for fine tuning and have absorption dyestuff The overall spectrum response of lens.Absorbance change on visible spectrum is known, and makees Change for the thickness of the layer in optical coating and the function of quantity.In the present invention, can make The required adjustment of spectrum attribute is provided with one or more layers.

In example system, by the TiO of monolayer₂(common AR coating material) produces Color changes.Figure 16 illustrates the monolayer TiO that 106nm is thick₂Spectrum absorbance.Figure 17 illustrates The color diagram of this same layer.For shown in transmission light CIE color coordinates (x, y) 1710 be (0.331, 0.345).Reflection light has CIE coordinate (0.353,0.251) 1720, causes opera pink.

Change TiO₂The thickness of layer changes the color of transmission light, as shown the most in figs. 18 and 19 Shown in the transmission spectrum for 134nm layer gone out and color diagram.In this system, transmission light Present CIE coordinate (0.362,0.368) 1910, and reflect light there is CIE coordinate (0.209,0.229) 1920.The transmission properties of various AR coatings and prediction or estimation thereof are as known in the art.Example As, it is possible to use various computer programs calculate and predict and formed by the AR material of known thickness The transmission effects of AR coating.The program of exemplary, non-limitative includes can be from Thin Film Center company obtain Essential Macleod Thin Films Software, can be from Software TFCaIc that Spectra company obtains and can obtain from FTG Software Associates FilmStar Optical Thin Film Software.Additive method can be used to predict AR coating Or other similar coatings or the performance of film.

In a system in accordance with the invention, can be by blue light absorption dyestuff and coating or other film groups Close to provide the blue light barrier system of color balance.This coating can be that AR on the front surface is coated with Layer, this AR coating is modified to correct transmission and/or the color of reflection light.Respectively at Figure 20 and 21 Shown in the absorbance of exemplary AR coating and color diagram.Figure 22 and 23 is shown respectively for having Blue light absorption dyestuff and there is no absorbance and the color diagram of the polycarbonate substrate of AR coating.Dyeing Substrate absorb the strongest in 430nm region, some being included in 420-440nm region are inhaled Receive.Dyeing substrate can as shown in Figure 20-21 with suitable AR coatings combine, to improve system The overall absorbance of system.Respectively for the dyeing base of AR coating after having shown in Figure 24 and 25 The absorbance of sheet and color diagram.

AR coating can also be applied to front portion (that is, the wearer of system of distance of ophthalmic system The farthest surface of eyes), cause the absorbance shown in Figure 26 and 27 and color diagram respectively. Although the light that this system presents high-transmission rate and institute's transmission is the most neutral, but reflection light has (0.249,0.090) CIE.Therefore, the effect of dyestuff is stopped for color balance blue light more up hill and dale Really, front AR coating can be revised and realize the color balance of necessity, to produce muted color structure. The absorbance of this structure and color diagram shown in Figure 28 and 29 respectively.In such configuration, Transmission and reflection light can be optimized to realize muted color.It may be preferred that internal reflection is wide It is about 6%.If reflection levels is annoying for the wearer of system, then can be by following Mode reduces reflectance further: add the most different absorption dyestuffs in substrates of lenses, This absorption dyestuff will absorb the different wave length of visible ray.But, the design of this structure achieves Significantly performance, and meet the need of the blue light stop ophthalmic system of color balance described herein Want.Total absorbance is more than 90%, and the color of transmission and reflection closely muted color white Point.As shown in Figure 27, reflection light has the CIE of (0.334,0.334), and transmission light has The CIE of (0.341,0.345), this indicates little or no gamut.

In some constructions, the anti-reflection coating of front amendment can be designed to stop to be suppressed The 100% of blue light wavelength.But, this may cause for wearer about 9% to 10% the back of the body Reflection.This reflection levels can be annoying for wearer.Therefore, by dyestuff will be absorbed It is combined in substrates of lenses, this reflection of the anti-reflection coating of amendment before using, it is possible to achieve The level that reflectance reduction to wearer is gladly accepted by intended effect simultaneously.By including one Or the reflection light observed of the wearer of the system of multiple AR coating can be reduced to 8% or more Few, or more preferably it is reduced to 3% or less.

The combination of front AR coating and rear AR coating can be referred to as dielectric stack, and permissible Various material and thickness is used to change transmission and the reflection characteristic of ophthalmic system further.Such as, Front AR coating and/or rear AR coating can be made up of different-thickness and/or material, specific to realize Color balance effect.In some cases, the material being used for setting up dielectric stack can not It is conventionally used for setting up the material of anti-reflection coating.That is, color balance coating can correct by The gamut that blue-absorbing dye in substrate causes, and do not perform anti-reflective function.

As it has been described above, filter lens is the another kind of technology stopped for blue light.Therefore, described Any one of blue light stop member can be or include that blue light stops filter lens, or hinders with blue light Gear filter lens combination.Such filter lens can include pectination filter lens (rugate filter), do Relate to filter lens (interference filter), bandpass filter mirror, band resistance filter lens, notch filtering light Mirror (notch filter) or dichroic filter (dichroic filter).

In an embodiment of the present invention, can be used in conjunction with other blue light barrier technique State the one or more of blue light barrier technique.The most for example, lens or lenticular unit can be in order to Block blue light effectively is carried out with dyestuff/coloring and pectination notch filtering light mirror.

Can be according to the ophthalmic system of the present invention uses appointing of configuration disclosed above and technology What is a kind of, to perform the stop of the blue light wavelength to 400-460nm or neighbouring.Such as, implementing In example, the wavelength of the blue light of stop can be in preset range.In an embodiment, this scope can To be 430nm ± 30nm.In other embodiments, this scope can be 430nm ± 20 nm.In other embodiments, this scope can be 430nm ± 10nm.In an embodiment, The absorbance of blue light wavelength within the above range can be restricted to incident wavelength by ophthalmic system Substantially 90%.In other embodiments, ophthalmic system can be by blue light ripple within the above range Long absorbance is limited to generally the 80% of incident wavelength.In other embodiments, ophthalmic system The absorbance of blue light wavelength within the above range can be limited to incident wavelength generally 70%.In other embodiments, ophthalmic system can saturating by blue light wavelength within the above range The rate of penetrating is limited to generally the 60% of incident wavelength.In other embodiments, ophthalmic system can be by The absorbance of blue light wavelength within the above range is limited to generally the 50% of incident wavelength.At it In his embodiment, the absorbance of blue light wavelength within the above range can be limited by ophthalmic system For incident wavelength generally 40%.In other embodiments, ophthalmic system can be by above-mentioned model The absorbance enclosing interior blue light wavelength is limited to generally the 30% of incident wavelength.In other embodiments In, the absorbance of blue light wavelength within the above range can be limited to incidence wave by ophthalmic system Long generally 20%.In other embodiments, ophthalmic system can be by indigo plant within the above range The absorbance of optical wavelength is limited to generally the 10% of incident wavelength.In other embodiments, ophthalmology The absorbance of blue light wavelength within the above range can be limited to incident wavelength substantially by system Upper 5%.In other embodiments, ophthalmic system can be by blue light wavelength within the above range Absorbance is limited to generally the 1% of incident wavelength.In other embodiments, ophthalmic system is permissible The absorbance of blue light wavelength within the above range is limited to generally the 0% of incident wavelength.Change Sentence is talked about, and ophthalmic system can be at least for the decay of the electromagnetic spectrum of wavelength within the above range It is 10% or at least 20% or at least 30% or at least 40% or at least 50% or at least 60% or at least 70% or at least 80% or at least 90% or at least 95% or at least 99% or be generally 100%

In some cases, it can be possible to be especially desired to the relative small portion of filter blue light spectrum, such as 400nm-460nm region.For example, it has been found that stop that too many blue spectrum can interfere with scotopia And physiological rhythm.Traditional blue light stops that ophthalmic lens generally stops the big of the blue spectrum of wide scope Amount much, " biological clock " of wearer can be had undesirable effect and have other by this Harmful effect.Accordingly, it may be desirable to stop the narrower scope of blue spectrum as described herein. Can filter the example system of the relatively small amounts of light in relatively small scope include stopping or Absorb the light with 400nm-460nm, 410nm-450nm and 420nm-440nm wavelength 5-50%, 5-20% and 5-10%.

Property selected as described above stop blue light wavelength while, can by ophthalmic system come Transmission visible ray electromagnetic spectrum at least the 80% of other parts, at least 85%, at least 90% or at least 95%.In other words, ophthalmic system for the wavelength outside blue spectrum (such as except at 430nm Wavelength outside those in scope around) decay of electromagnetic spectrum at place can be 20% or more Little, 15% or less, 10% or less, and be 5% or less in other embodiments.

It addition, embodiments of the invention can be composed by shielding of ultraviolet radiation UVA and UVB further Carry and have the infrared radiation of the wavelength more than 700nm.

Any one of ophthalmic system disclosed above can cover eye wear product (eyewear) in, including the eye wear product of external wear, such as glasses, sunglasses, protect Eyepiece or contact lens.In such eye wear product, because the blue light stop member of system After color balance parts, thus when wearing eye wear product blue light stop member always than Color balance parts are closer to eyes.Ophthalmic system can also be used in as operation implantable manually In the such goods of crystalline lens.

As used herein, if parts suppression at least some transmission in wave-length coverage and The slight influence that is transmitted with for visible wavelength outside this range does not affect, then portion Part " optionally suppression " or " optionally filtering " this wave-length coverage.Such as, if selected Selecting property filter lens filters the wavelength of 400-460nm, then it is only decayed these wavelength, and unattenuated Other visible wavelengths.Even if the wavelength outside the unattenuated described range of choice of selectivity filter lens, This filter lens can also in systems with such as UV filter lens, infrared ray filter lens or be directed to not The another kind of selectivity filter lens of the range of choice of (although may be overlapping) is one or more together Other filters combines.US 2008/0291392 provides an embodiment of double filter lens system, It is incorporated into herein by the entirety quoting US 2008/0291392.At described chosen wavelength range Interior decay can be the most substantially consistent (as in pectination filter lens), Or can within the range on Reduction Level change (as in the dyestuff have absorption peak that Sample).Similarly, " range of choice (selected range) " instruction is decayed by selectivity filter lens Wave-length coverage." the blue light wavelength range of choice (selected range of blue light Wavelength) " referring to the scope of blue light wavelength in 400-500nm, it does not comprises The gamut of 400-500nm.Therefore, the decay of selectivity filter lens is less than the whole spectrum of visible ray, And the preferably less than whole spectrum (400-500nm) of blue light wavelength.

Some embodiments use film to carry out block blue light.Film in ophthalmology or other system can select Suppress to selecting property at least the 5% of blue light in the range of 400nm-460nm, at least 10%, at least 20%, at least 30%, at least 40% and/or at least 50%.Film and/or to comprise the system of this film permissible It is that color balance is so that observer and/or user are perceived as colourless.Comprising according to the present invention The system of film can have 85% or more preferable scotopia luminous transmittance (scotopic of visible ray Luminous transmission), and further such that the people through film or system viewing has Substantially normal colour vision.

Figure 30 illustrates one exemplary embodiment of the present invention.Film 3002 can be arranged in one or Between two-layer or the region of multiple base materials 3001,3003.As described further at this, Film can comprise the dyestuff of the light optionally suppressing specific wavelength.This base material can be suitable Any material of the other system of film maybe can be arranged together in lens, ophthalmic system, window.

Figure 31 illustrates the optical transmittance characteristic of the exemplary film according to the present invention, wherein, Block about 50% of blue light in 430nm ± 10nm scope, simultaneously in visible spectrum Other wavelength cause the loss of minimum.Absorbance shown in Figure 31 is exemplary, and can To understand, for many is applied, it may be desirable to the optionally suppression blue light less than 50%, And/or, the specific wavelength suppressed can change.It is believed that in numerous applications, permissible By stopping that the blue light less than 50% reduces or prevents cell death.It may be preferred, for example, that Optionally suppress about 40% of light in 400-460nm scope, the most about 30%, the most about 20%, the most about 10%, and the most about 5%. Optionally suppress light in a small amount can allow the infringement preventing causing due to high energy light, the least Enough to make this suppression scotopia and/or physiological rhythm not to system user produce harmful effect.

Figure 32 illustrates the film 3201 covered in ophthalmic lens 3200 according to the present invention, wherein, Film 3201 is sandwiched between the layer of ophthalmic materials 3202,3203.The most for example, ophthalmic materials The thickness of front layer in the range of 200 microns to 1,000 microns.

Similarly, Figure 33 illustrates the example system 3300 according to the present invention, such as automotive windshield. Film 3301 can cover in system 3300, and wherein it is sandwiched in basic material 3302,3303 Between Ceng.Such as, it is the situation of automotive windshield in system 3300, basic material 3302,3303 It can be normally used windshield.It will be appreciated that include vision, display, ophthalmology and In the various other systems of other system, can make in the case of without departing from the scope of the present invention With different basic materials.

In one embodiment, can have, at the visible ray of associated transmissions, the ring the most specifically composed Border operates the system according to the present invention.In such a situation, it may be desirable to the mistake of customization film Filter effect, with the light optimizing this object transmission, reflect or launch.This be probably such as institute's transmission, The color of the light of reflection or transmitting is the situation of the problem of major concern.Such as, when according to this Bright thin film is used in camera flash-light or flash lamp filter mirror, or when using together with which, can Can expect that the color of the image of institute's perception or leaflet is as close possible to true colors.The most such as, In the instrument of the back conditions that the film according to the present invention can be used in the glasses observing patient.At this In the system of sample, this film does not disturb color that is amphiblestroid real and that observe to be probably important. The most such as, the artificial light source of particular form may benefit from the wavelength customization of the film using the present invention Filter lens.

In one embodiment, the film of the present invention can be used in maybe can changing of photochromic, electricity color In ophthalmic lens, window or the automotive windshield of coloring.Such system can allow not swash in coloring The environment lived prevents from UV optical wavelength, direct sunlight intensity and blue light wavelength.At this In embodiment, the blue light wavelength protection attribute of film can work, and whether activates nothing with coloring Close.

In one embodiment, film can allow optionally to suppress blue while color balance Light, and by there is visible ray 85% or bigger scotopia luminous transmittance.Such film may Use for the relatively poor light transmission of such as driving glasses or Sports spectacles is useful, and The visual performance of raising can be provided owing to improve contrast sensitivity.

For some applications, it may be desirable to the system according to the present invention optionally suppresses as at this The blue light described, and have less than about 85% on visible spectrum, it is common that about 80-85% Luminous transmittance.This can be following situation: such as, the basic material used in systems The refractive index higher due to it and suppress the more light crossing on whole visible wavelength.As Concrete example, the more light that high index of refraction (such as, 1.7) lens can be reflected on wavelength, Cause the luminous transmittance less than 85%.

In order to avoid, traditional blue light barrier system present in problem is reduced or eliminated, can Expectation can reduce the transmission still not eliminating phototoxic blue light.The pupil of eyes is in response to special sieve The photopic vision retinal illuminance of blue metering, it is amphiblestroid to have entering of the relevant sensitivity of wavelength Penetrate the product of the projected area of flux and pupil.It is positioned at the filter lens before retina, whether No as in intraocular lens in eyes, in replacing at contact lens or cornea Attach to eyes or as in eye-use lens in the light path of eyes, can reduce for The luminous flux that retina is total, and stimulate pupil dilation, thus compensate subtracting in illumination at the scene Few.When being exposed to lightness stabilized (luminance) in the field, pupil diameter generally around with Luminance-reduction and increase value fluctuation.

Under being used by Moon and the Spencer J.Opt.Soc.Am. volume 33 page 260 in nineteen forty-four The functional relationships between pupil area and field illumination that the equation for pupil diameter in face describes System:

D=4.9-3tanh (Log (L)+1) (0.1)

Wherein, d measures with millimeter, and L is with cd/m²The illumination of metering.Figure 34 A illustrates work For field illumination (cd/m²) the pupil diameter (mm) of function.Figure 34 B is shown as scene Pupil area (the mm of the function of illumination²)。

By international CIE standards, illumination is defined as the visual sensitivity for wavelength spectrally Weighted integral:

Wherein, dark (night) is regarded, K_m' equal to 1700.06lm/W, bright (daytime) is regarded, K_m=683.2lm/W and spectral luminous efficiency function V_λAnd V_λ' define standard photopic vision and Scotopic observers.Such as can access on August 8th, 2007 from finally Http:// webvision.med.utah.edu/Phychl.html obtain Michael Kalloniatis and The Fig. 9 of " psychophysics (Psychophysics of Vision) of vision " of Charles Luu In illustrate luminous efficiency function V_λAnd V_λ', it is herein incorporated by quoting this article.

The intervention of the absorbability ophthalmic devices of intraocular lens, contact lens or glasses form according to Equation below reduces illumination:

Wherein, T_λIt it is the absorbance that the wavelength of optical element is relevant.Show in tablei for existing Have technology blue-light blocking lens each for principal value of integral in equation 1.3, this value quilt It is normalized to the brightness value not filtered calculated from equation 1.2.

Table I

Reference table I, decreases its value of optical filtering according to the ophthalmology filter lens of Pratt by scotopia sensitivity 83.6%, according to this decay of equation 1.1 will make night vision be deteriorated and stimulate pupil dilation.By Scotopia flux is decreased 22.5% by the device that Mainster describes, and this is serious not as Pratt device, But it is the biggest.

On the contrary, absorbability or reflexive ophthalmic devices is used partly to decline according to the film of the present invention Subtract purple and blue light, scotopia illumination is reduced 15% less than its value not filtered simultaneously.Order People surprisingly, finds that the system according to the present invention optionally suppresses desired blue region, with Time have slight influence or not impact for photopic vision and scotopia.

In one embodiment, perylene (C20H12, CAS#198-55-0) is be enough to Its concentration absorbing the light absorbing about 2/3rds at maximum 437nm and thickness cover eye In section's device.Figure 35 illustrates the transmission spectrum of this device.The photograph caused by this filter lens It is only about 3.2% that degree changes for scotopic viewing conditions (scotopic viewing condition), and And be about 0.4% under photopic vision viewing condition (photopic viewing condition), in Table I Display.According to Baeyer (Beer) law, the concentration of the perylene in aggrandizement apparatus or thickness fall Absorbance at each wavelength low.Figure 36 illustrates that Perylene concentrations is 2.27 times of Fig. 6 The transmission spectrum of device.Although this device optionally stops the phototoxicity more than the device in Fig. 6 Blue light, but it by scotopia luminance reduction less than 6%, and by photopic vision illumination (scotopic Illuminance) reduce less than 0.7%.Note, eliminate from the spectrum of Figure 35 and 36 Reflection, only to illustrate the assimilation effect of dyestuff.

Dyestuff in addition to perylene can have in blue wavelength range at blue light or substantially Strong absorbance, and there is in other regions of visible spectrum the least absorbance or do not have Absorbance.The example of such dyestuff shown in figures 4-6 can include based on porphyrin, coumarin and The molecule of acridine, this molecule can be used separately or in combination to be provided at 400nm 460 Reduce at nm but the transmission not eliminated.Method and system the most described herein can use base In the similar dyestuff of other molecular structures, have imitation (mimic) perylene, porphyrin, fourBase The concentration of the transmission spectrum of porphyrin magnesium (MgTMP), coumarin and acridine or derivatives thereof.

In one embodiment, selectivity filter lens imitates the most one or more examples The transmission spectrum of property dyestuff.Dyestuff is used as with reference to filter lens to design use the most provided herein The similar filter lens of substitution material.Filter lens can imitate by filtering roughly the same wavelength Transmission spectrum with reference to filter lens.Such as, imitate filter lens (mimic filter) can filter and reference The wave-length coverage that filter lens is roughly the same, in one or both ends ± 1 of this scope, 2,3,4,5, 6,7,8,9,10,15,20,25 or 30 wavelength.In another embodiment, filter Mirror can imitate with reference to filtering by selected wavelength filters about the same suppression level The transmission spectrum of mirror.Such as, with reference to maximum suppression (or minimum transmission) and the imitation filter of filter lens The maximum suppression (or minimum transmission) of light microscopic can in about 1 each other, 3,5,7,10, 15, in 20,25 or 30%.In another embodiment, imitate filter lens to imitate with reference to filter lens Wave-length coverage and suppression level.

Can be completed root by the distinct methods that the people of practice in optics manufacture field is familiar with It is inserted in light path according to the dyestuff of embodiments of the invention.This dyestuff can be directly contained in substrate In, it is added on polymer coating, absorbs in lens, covers the layer including dye-impregnated layer In laminated structure or as the composite of the microgranule with dye-impregnated.

According to another embodiment of the invention, can apply in the middle part of purple and blue chromatographic regions Point ground reflection and at longer wavelength the dielectric coating of antireflection.In such as New York The textbook " Thin Film Optical Filters " that mcgraw-hill, inc publishes for 1989 (Angus McLeod work) summarizes the side for designing suitable dielectric optical filter lens Method.Figure 37 illustrates according to the present invention for SiO₂And ZrO₂Folded exemplary of six layer stack Penetrate spectrum.Referring again to Table I, it can be seen that this optical light filter blocks phototoxic indigo plant Light and purple light, simultaneously by scotopia luminance reduction less than 5% and photopic vision luminance reduction is little In 3%.

Although many traditional blue light barrier technique attempt to suppress blue light as much as possible, but work as Front research shows, in numerous applications, it may be desirable to suppress relatively small amounts of blue light.Example As, in order to prevent the less desirable impact for scotopia, it may be desirable to according to the ophthalmology of the present invention System only suppresses about the 30% of blue light (that is, 380-500nm) wavelength light, or the most only About the 20% of blue light, the most about 10%, and the most about 5%.It is believed that By suppression blue light 5% is so much, it is possible to reduce cell death, the simultaneously blue light of this degree Reduce for using the scotopia of those people of this system and/or physiological rhythm behavior to have the least shadow Ring or not impact.

As used herein, it is described as pressing down according to the film optionally suppressing blue light of the present invention Make the light quantity measured relative to the fundamental system comprising this film.Such as, ophthalmic system can use Merlon or other similar substrates for lens.It is generally used for the material of such substrate The different amounts of light in visible light wave strong point can be suppressed.If the blue light according to the present invention stops Film is added to this system, then it can optionally suppress relative in the case of there is no film The 5% of all blue light wavelengths of the light measurement of transmission at identical wavelength, 10%, 20%, 30%, 40% and/or 50%.

Method and apparatus disclosed herein can minimize and preferably eliminate blue light stop to be caused Color-aware on skew.It is derived from by the color of the visual system perception of people and there is difference The neural process of the optical signal on the retinal pigment of spectral response characteristic.In order to mathematically describe Color-aware, by product and the spectral irradiance of the color matching functions that three wavelength are relevant (spectral irradiance) integrates and constructs color space.Result is the face for characterizing perception Three numbers of color.Pass through International Commission on Illumination (Commission Internationale de L'eclairage) uniform (L*, a*, b*) color space that (CIE) sets up may be used for characterizing sense The color known, although similar being calculated as in color science field based on the color standard substituted In technical staff be familiar with, and can also be used.(L*, a*, b*) color space defines Brightness (brightness) on L* axle and the color in the plane defined by a* and b* axle.Such as The homogeneous color space defined by this CIE standard is probably preferably for calculating and comparing application , because the color distinction of the cartesian distance in this space and the perception between two objects Amplitude is proportional.The most generally approve the use of homogeneous color space, such as in New York Wiley company nineteen eighty-two publish " Color Science:Concepts and Methods. Quantitative Data and Formulae " described in (Wyszecki and Stiles work).

A kind of optical design according to method and system described herein can use description vision ring The palette of the spectrum in border.Its indefiniteness example is Meng Saier colour atla (Munsell matte) toning Plate, it is by the most dramatically different 1,269 set up by psychophysics experiments Colored tile is constituted.The spectral irradiance of these tiles is measured under standard illumination conditions.With by Each of these tiles that D65 daylight luminous body in (L*, a*, b*) color space irradiates The array of corresponding color coordinates is the reference for cross-color, and is shown in Figure 38. Then by blue light, the spectral irradiance of color tile is stopped that filter lens is modulated, and calculates new one Group color coordinates.It is corresponding that each tile has the geometric displacement that offset by with (L*, a*, b*) coordinate The perception color of amount.This calculating have been applied to Pratt blue light stop filter lens, wherein, Average color distortion is 41 just noticeable difference (JND) units in (L*, a*, b*) space. The minimum distortion caused by Pratt filter lens is 19 JND, and maximum is 66, and standard deviation is 7 Individual JND.The Nogata of gamut for whole 1,269 color tiles is shown at Figure 39 A (top) Figure.

With reference now to Figure 39 B, Mainster blue light stop that the gamut that filter lens causes has minimum It is worth 6 JND, 19 JND of meansigma methods, 34 JND of maximum and 6 JND of standard deviation.

Use described above has the perylene dyes of two concentration or the basis of reflecting filters Inventive embodiment can have the gamut more much smaller than conventional apparatus, is whether measured as putting down All, minimum or maximum distortion, as shown in Table II.Figure 40 illustrates for the dinaphthyl according to the present invention The rectangular histogram of the gamut of embedding benzene dyestuff substrate, the transmission spectrum of this substrate is shown in Figure 35.It is worth It is to be noted that, it was observed that the deviation ratio on all colored tiles is for by Mainster and Pratt etc. Those of the conventional apparatus described are much lower and much narrower.Such as, simulation result shows, for For the film of the present invention, (L*, a*, b*) offset by as little as 12 and 20 JND, all As little as 7-12 JND of mean deviation on tile.

Table II

In one embodiment, reflection and absorber element combination can with filtering noxious blue photons, Keep of a relatively high luminous transmittance (luminous transmission) simultaneously.This can allow root Avoid or reduce pupil dilation according to the system of the present invention, protect night vision or prevent night vision undermined, And reduce cross-color.One example of this means is by the electrolyte heap shown in Figure 37 The folded perylene dyes combination with Figure 35, produces the transmission spectrum shown in Figure 41.Observe This device has photopic vision transmission, the scotopic luminous transmission of 93.2% and the average color of 11 JND of 97.5% Move.Figure 42 illustrates cross-color Meng Saier tile being collected in the sunlight to this device Rectangular histogram.

In another embodiment, ophthalmology filter lens outside eyes, such as eyeglass lens (spectacle lens), protective eye lens (goggle) or eyeshield (visor) etc..When using traditional filter lens Time, when being watched by external observer, wearer face color may by lens coloring, That is, when being watched by another person, face color or skin color are generally by blue-light blocking lens Skew.It is frequently not the most desired with the yellowish discoloration of blue light absorption.For Identical, with wearer with above for described by Meng Saier tile of the process of this gamut of littleization Skin reflectance replace Meng Saier colour tile those.The color of skin is pigment, blood Stream and the function of lighting condition.Shown in Figure 43 A-B, the skin from the most agnate object is anti- Penetrate the representative series of spectrum.Figure 44 illustrates the exemplary skin reflectance for Caucasia object Spectrum.(L*, a*, b*) color coordinates of this skin in daylight (D65) illuminates be (67.1,18.9, 13.7).Pratt blue light stop filter lens insertion these color coordinates are changed into (38.9,17.2, 44.0), the i.e. skew of 69 JND units.Mainster blue light stops that filter lens is inclined by color coordinates Move 17 JND units and arrived (62.9,13.1,29.3).In contrast, dinaphthyl as described herein Embedding benzene filter lens causes the gamut or 1/3rd of Mainster filter lens of only 6 JND.In Table III Shown in use various blue light to stop the filter lens exemplary Caucasia skin under daylighting Collecting of aesthetic feeling gamut.Data shown in tablei are normalized and are caused by basic material to remove Any effect.

Table III

In one embodiment, luminous body can be filtered and not eliminated retina to reduce The flux of blue light.Principle described herein can be used to use suction between visual field and light source Receive or reflecting element realizes this point.Perylene is comprised for example, it is possible to covered by framework window Film so that the transmission spectrum of window and mating shown in Figure 35.Compare with the window of uncoated, this The filter lens of sample does not the most cause pupil dilation, and it does not draws when external sunlight is by it Play appreciable gamut.Blue light filter lens according to the present invention can be used on artificial luminous body, Such as fluorescent lamp, electric filament lamp, arc lamp, flash lamp and diode lights and display etc..

Various material can be used to manufacture the film according to the present invention.Two kinds of such exemplary materials Material is polyvinyl alcohol (Poly Vinyl Alcohol) (PVA) and polyvinyl butyral resin (Poly Vinyl Butyral)(PVB).In the case of PVA film, can be by partially or completely Hydrolyzed poly vinyl acetate (polyvinyl acetate) is to remove aceticoceptor (acetate groups) Prepare.Because useful thin film formation, emulsifying and adhesion properties, PVA film is probably expectation 's.It addition, PVA film has high-tensile, elasticity, high-temperature stability, and provide good Good oxygen obstruction.

PVB film can be prepared by polyvinyl alcohol reaction in hutanal.PVB may fit Together in the application requiring high intensity, optical clarity, elasticity and toughness.PVB also has good Film is formed and adhesion properties.

PVA, PVB and other suitable films can be extruded, from solution-cast, spin coating and Then solidify, or dip-coating and then solidifying.Its that be known in the art can also be used His manufacture method.There is multiple integration and set up the mode expecting to compose the dyestuff needed for attribute of film. Exemplary dyes integration method include vapor deposition, chemical crosslinking in film, at little polymer Then dissolving in microsphere is integrated in film.Can be from including Keystone, BPI & Phantom Company buy suitable dyestuff.

The dyeing of most of eyeglass lens completes after manufacturer transports at lens.Therefore, It may be desirable to merge blue light absorption dyestuff during the manufacture of lens itself.Do so, can be by Filter and color balancing dye is incorporated to hard conating and/or the primer coating (primer being associated Coating), in, this primer coating being associated contributes to the bonding of hard conating and lens material.Example As, it is saturating that the ending that primer coating and the hard conating being associated often process in manufacture is added to glasses Mirror or the top of other ophthalmic systems, to provide other durability and scratch-resistant for final products Wound property.Hard conating is typically the outermost layer of system, and can be placed in system front surface, On both rear surface or front and rear surface.

Figure 47 illustrates have hard conating 4703 and the bonding that is associated promotes primer coating 4702 Example system.Can be from such as Tokuyama, UltraOptics, SDC, PPG and LTI Manufacturer obtains exemplary hard conating and bonding promotes primer coating.

In a system in accordance with the invention, blue light stops that dyestuff and color balancing dye can include In primer coating 1802.Blue light stops and color balancing dye can also be included in hard conating In 1803.This dyestuff is not necessarily comprised in same coating.Such as, blue light stops that dyestuff can wrap Include in hard conating 1803, and color balancing dye can be included in primer coating 1802. Color balancing dye can be included in hard conating 1803, and blue light stops that dyestuff can include In primer coating 1802.

The method being known in the art can be used to deposit the priming paint according to the present invention and hard painting Layer, the method includes spin coating, dip-coating, sprays, evaporates, sputters and chemical vapor deposition.Want The blue light included in each layer stops and/or color balancing dye can deposit with this layer simultaneously, all As dyestuff is dissolved in liquid coating material, and result produce mixture be applied to be System.This dyestuff can also be deposited, such as in solidification or dry in independent process or son process Or splash dyestuff from the teeth outwards before application coating.

Hard conating and/or primer coating can perform function, and realize at this about film description Benefit.Specifically, this coating can optionally suppress blue light, keeps desired bright simultaneously Depending on, scotopia, physiological rhythm and phototoxicity levels.Can also be with arbitrary and different combinations The ophthalmic system comprising film as described herein uses hard conating as described herein and/ Or primer coating.As a specific example, ophthalmic system can include optionally suppressing blue light Film and the hard conating of offer color correction.

The selectivity filter lens of the present invention can also provide the contrast sensitivity of raising.Such system System for optionally filtering harmful black light and visible ray, simultaneously for photopic vision, scotopia, Colour vision and/or physiological rhythm have the impact of minimum, keep acceptable simultaneously or even improve Contrast sensitivity.The present invention can be built so that in a particular embodiment, selectivity filter lens The final residual color of the device being applied to is the most colourless, and need not substantially In other embodiments of transparent residual color, residual color can be yellowish.Preferably It is that the yellow of selectivity filter lens is not disgusting for subjective individual wearer.Permissible The yellow colour index using such as ASTM E313-05 measures yellow quantitatively.Preferably, choosing Selecting property filter lens has no more than 50,40,35,30,25,23,20,15,10,9,7 Or the yellow colour index of 5.

The present invention can include selective light wavelength optical filtering embodiment, such as: window, automotive windshield, Bulb, flashbulb, fluorescent lamp, LED illumination, television set, computer monitor etc..Impact Amphiblestroid any light optionally can be filtered by the present invention.The most for example, can pass through Film implements the present invention, and this film includes: selectivity filter dye or pigment；After manufacturing substrate The dyestuff increased or pigment composition；The dye component manufacturing or being formed integration with substrate material； Synthesis and non-synthetic pigment, such as melanin (melanin), phylloxanthin (lutein) or Semen Maydis Xanthin (zeaxanthin)；As in contact lens, (there is one as visual coloring Or multiple color) the selectivity filter dye that provides or pigment；(hard in ophthalmology scratch resistance coating Coating) in provide selectivity filter dye or pigment；Ophthalmology anti-reflection coating provides Selectivity filter dye or pigment；The selective light wavelength filter dye provided in hydrophobic coating Or pigment；Interference filter；Selective light wavelength filter lens；The choosing provided in light color lens Selecting property optical wavelength filter dye or pigment；Or, the choosing provided in the matrix of bulb or fluorescent tube Selecting property optical wavelength filter dye or pigment.It should be pointed out that, that the present invention considers for being selectively over The wavelength of one particular range of filter or the wavelength of multiple particular range, and not on visible spectrum all The selective light wavelength filter lens of even ground wavelength-filtered.

Those skilled in the art readily know how to provide selective light wavelength to substrate material Filter lens.The most for example, this selectivity filter lens can: be drawn, inject, impregnate, Add the raw material of substrate to；Add resin before the polymerization to；By including that selectivity filters The film of mirror dyestuff or pigment to be layered in optical lens.

The present invention can utilize dyestuff and/or the pigment of debita spissitudo, the most for example, this dyestuff And/or pigment e.g. perylene, porphyrin or their derivant.Dinaphthyl is observed with reference to Figure 48 The variable concentrations of embedding benzene and the ability of the function of the wavelength of light being blocked in around 430nm.Permissible Transmission level is controlled by dye strength.Other dyestuff chemistry character allows to adjust absorption peak Position.

There is the perylene of suitable concentration level while remaining substantially without the outward appearance of color Photopic vision, scotopia, physiological rhythm and phototoxicity ratio provide balance.

Table IV

Perylene for debita spissitudo, it was observed that contrast sensitivity increases.See example 2, table VI.It should be pointed out that, that dyestuff based on perylene or pigment race are only used as example for implementing this Invention.When using such dyestuff, according to embodiment or application, dyestuff can be formed and make It is on molecule or is chemically bonded to substrate or is attached to put on the coating of substrate so that dye Material does not filters.The most for example, its application will be for contact lens, IOL, corneal inlay, Cornea covering etc..

Can be with combination selection filter lens to hinder when other visible wavelengths of scientific discovery are harmful to Other target wavelengths.For example, it is possible to combination selection filter lens is with when identifying other harm Hinder more than one target wavelength range.In one embodiment, system includes: 1) selectivity Filter lens, it reduces the harm being associated with A2E chromophore；And, 2) one or more separately Outer filter lens, it reduces the harm that another kind is identified, such as, it is seen that optical wavelength endangers.

In one embodiment of the invention, contact lens is made up of perylene dyes, and these are two years old Naphthalene embedding benzene dyestuff is configured to so that it does not filters from contact lens material.This dyestuff is entered one Step is formulated so that it provides the coloring with yellow colour cast.This yellow colour cast allows stealthy eye Mirror have be referred to as wearer process colour.Perylene dyes or pigment carry further Selective property filters, as shown in figure 48.This optical filtering provide retina protection and strengthen right Specific sensitivity, and compromise the most in any effective manner photopic vision of people, scotopia, colour vision or physiology The rhythm and pace of moving things.

In the case of the embodiments of the invention of contact lens, the most for example, can pass through Draw in contact lens, apply dyestuff or pigment so that it is positioned at the center 10 of contact lens In the circle of mm diameter or less, preferably at the contact lens overlapped with the pupil of wearer In the 6 8mm diameters at center.In this embodiment, it is provided that selective light wavelength filters Dyestuff or pigment concentration be raised to wearer provide increase contrast sensitivity (with do not wear Contact lenses is compared) and compromise the most in any effective manner photopic vision of wearer, scotopia, color Feel or the level of physiological rhythm (one or more or whole).

Preferably, (Functional Acuity is tested by the contrast sensitivity user Contrast Test)(FACT^TMSinusoidal wave grating test) on mark at least about 0.1,0.25, 0.3, the increase in contrast sensitivity is demonstrated in the increase of 0.5,0.7, I, 1.25,1.4 or 1.5. Relative to photopic vision, scotopia, colour vision and/or the physiological rhythm of wearer, ophthalmic system preferably will One of these characteristics or the characteristic levels in the case of being all held at not this ophthalmic system 15%, in 10%, 5% or 1%.

In another embodiments of the invention utilizing contact lens, it is provided that cause slightly yellow The dyestuff of coloring or pigment, it is positioned at center 5 7mm of contact lens diametrically, and Wherein in periphery, to center, coloring adds the second color dyes.In this embodiment, it is provided that choosing The dye strength that selecting property optical wavelength filters is raised to provide good contrast sensitivity to wearer And the photopic vision of wearer of compromising the most in any effective manner, scotopia, colour vision or The level of physiological rhythm (one or more or whole).

In another embodiments of the invention utilizing contact lens, it is provided that dyestuff or pigment, Make it be positioned at contact lens from substantially while to another side complete the most diametrically.Implement at this In example, it is provided that the dye strength that selective light wavelength filters is raised to provide fine to wearer Contrast sensitivity and the photopic vision of the wearer that compromises the most in any effective manner, Scotopia, colour vision or the level of physiological rhythm (one or more or whole).

When within human or animal tissues or on use various embodiments of the invention time, below Mode of stating is to prepare dyestuff: be chemically bound to the substrate material embedded, thereby ensure that it does not exists Cornea tissue around filters.For providing the chemical hook (chemical allowing this combination Hook) method is known in the industry at chemistry and polymer row.

In another embodiments of the invention, intraocular lens includes that selective light wavelength filters Mirror, it has a yellow coloring, and provides the contrast sensitivity of improvement further to wearer, And compromise the most in any effective manner photopic vision of wearer, scotopia, colour vision or physiological rhythm (one or more or whole).When on intraocular lens or within use selectivity filter During light microscopic, the level of dyestuff or pigment can be increased to exceed eyeglass, because manually brilliant The aesthetic feeling of shape body is sightless for the people of viewing wearer.This allows to increase dyestuff or face The ability of the concentration of material, and provide the contrast sensitivity of the improvement of the most higher level, And compromise the most in any effective manner photopic vision of wearer, scotopia, colour vision or physiological rhythm (one or more or whole).

In another embodiment of the present invention, a kind of eyeglass lens includes that selective light wavelength is filtered Light microscopic, this filter lens includes the dyestuff with perylene, and wherein, the preparation of this dyestuff provides There is the eyeglass lens substantially free of colored appearance.And, it provides the right of improvement to wearer Specific sensitivity, and compromise the most in any effective manner photopic vision of wearer, scotopia, colour vision Or physiological rhythm (one or more or whole).In this specific embodiment of the present invention, Within the surface being positioned at eyeglass lens or on film apply dyestuff or pigment.

In one embodiment, system includes blue light stop member and photochromic parts.More specifically, Ophthalmic system may include that blue light stop member, and it optionally filters and is included in about 430nm The blue light wavelength range of choice of the wavelength at place；And photochromic parts, this photochromic portion when activated Part filtration includes the visible ray of the wavelength outside the described blue light wavelength range of choice.

Component representation symbol " photochromic (photochromic) " and " blue light stops (blue-blocking) " Need not be mutually exclusive.Such as, photochromic dyes is permissible, but need not, stop at least some blue light Wavelength.Equally, blue light stop member can be photochromic or non-photochromic.An embodiment In, blue light stop member is non-photochromic, in order to provide continuous print blue light barrier functionality, i.e. Blue light under completely or generally whole lighting conditions stops.Even if can at blue light stop member Can be in photochromic embodiment, remain on preferably, blue light be blocked in the most complete Work continuously under portion's lighting condition.Therefore, blue light stop acts as independently with photochromic parts With.

Photochromic blue light barrier system e.g. (can include that prescription or OTC (over-the-counter) are saturating by ophthalmic lens Mirror), eyeglass, contact lens, intraocular lens, corneal inlay, cornea cover, angle Film graft, electro-active lens, windscreen or window.

Blue light stop member can be any one that blue light described herein stops embodiment.Cause This, in one embodiment, blue light stop member is perylene, porphyrin, coumarin, a word used for translation At least one of pyridine and derivant thereof.In one embodiment, this blue light stop member includes two Naphthalene embedding benzene or derivatives thereof.In another embodiment, this blue light stop member include porphyrin or Its derivant, such as fourBase porphyrin magnesium (MgTMP).Blue light stop member can also include The mixture of dyestuff.

In one embodiment, blue light stop member optionally filters and selects at described blue light wavelength Select at least the 10% of light in scope, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or about 100%.The described blue light wavelength range of choice can be included in about Wavelength at 430nm, such as 430nm ± 10,20 or 30nm.In another embodiment, The described blue light wavelength range of choice includes from about 420nm to about 440nm, from about 410 Nm to about 450nm or from about 400nm to the wavelength of about 460nm.

The light color lens of those such as manufactured by Transitions Optical is known in the art 's.Photochromic parts are activated by having the activation of the light of specific wavelength.That activates is photochromic Parts decrease the transmission by system.In other words, the photochromic parts of activation make system become Secretly.When removing activation stimulation (such as, activate wavelength), photochromic parts may return to not Active state, feature is the absorbance improved.

In one embodiment, the average transmittance ratio on the visible spectrum in the system activated Average transmittance little at least 20% on visible spectrum in inactive system.In other embodiments In, activate by visible spectrum average transmittance reduce at least about 10%, 20%, 25%, 30%, 40%, 50%, 60% or 70%.

In one embodiment, photochromic parts quickly respond in the change at external lighting conditions, It is typically to activate the change of stimulus.Therefore, in one embodiment, by inactive photochromic Parts carry out activate stimulate after, photochromic parts will less than 10,7,5,4,3,2 or 1 minutes Internal conversion is state of activation.Similarly, in another embodiment, after removing activation stimulation, Activate photochromic parts will less than 10, internal conversion in 7,5,4,3,2 or 1 minutes be inactive State.

Exemplary photochromic dyes includes, but are not limited to: triarylmethane (triarylmethanes), Stilbene (stilbenes), azepine stilbene (azastilbenes), nitrone (nitrones), prisoner Essence anhydride (fulgides), spiro-pyrans (spiropyrans), aphthopyrans (naphthopyrans), Spiral-oxazines (spiro-oxazines) and quinone (quinones).

The selection of photochromic parts can rely partially on desired activation to stimulate.An enforcement In example, photochromic parts are by UVB, UVA, blue light, visible ray and at least the one of Infrared wavelength Plant and activate.In another embodiment, photochromic parts are swashed by UVB, UVA or Infrared wavelength Live.By selecting UVB or UVA wavelength to stimulate as activating, photochromic parts are valuably in outdoor It is activated and is suppressed in indoor.Although activating stimulation can be blue light or other visible light waves Long, but these embodiments may be dimmed in indoor environment, and this is not phase for some application Hope.Alternatively, if blue light stop member is also photochromic, then it can be desirable to have permissible The activation thorn that the activation keeping these parts the retina therefore keeping indoor and outdoors are protected Swash.

In yet another embodiment, photochromic parts are had about 380nm to about 410nm's The photoactivation of wavelength.As at US 7, described in 166,357, this activates to stimulate and allows photochromic parts It is activated after the UV filter lens of such as automotive windshield.This advantageously provides can be in automobile User keep the ophthalmic lens of optical Response when wearing.

System may further include UV filter lens, such as UVA and/or UVB filter lens.? In one embodiment, UV filter lens does not stop the activation of any photochromic parts.Can such as pass through Following manner realizes this point: after UV filter lens is positioned at photochromic parts (below), First UV light is incident on photochromic parts, but then by UV before arriving wearer Filter lens filters.In another example, UV filter lens does not filter the wavelength activating photochromic parts, Or the most they are not filled into the degree stoping activation.

By including photochromic parts and blue light stop member, system is the most always to provide blue light ripple Long retina protection, adjusts the absorbance of visible ray simultaneously also according to external lighting conditions.

In one embodiment, the blue light wavelength range of choice average described in the system activated Absorbance is less than the average transmittance of the blue light wavelength range of choice described in inactive system.No Be bound by theory, it is believed that when activation system, the described blue light wavelength range of choice average thoroughly Rate of penetrating reduces, because blue light stop member and photochromic parts filter the described blue light wavelength range of choice, Produce additive effect.This embodiment is characterised by the retina protection strengthened, and is particularly swashing In the state of living.Bright conditions may make platycoria, adds the chance of retinal damage. For example is implemented, bright conditions is likely to the blue light protection that activation system increases with offer, Therefore protection wearer is from the exposure increased.

Such as variations in temperature, other environmental conditions of the most relatively low temperature may weaken photochromic The ability of lens filter blue light wavelength.Therefore, also include that the photochromic system of blue light stop member can To compensate weakening in retina protection under certain environmental conditions.

In another embodiment, the blue light wavelength range of choice flat described in the system activated Equal absorbance is average with the blue light wavelength range of choice described in the same system in disabled state Absorbance is substantially the same.In one embodiment, blue light wavelength described in the system activated The average transmittance of the range of choice is the average of the blue light wavelength range of choice described in inactive system In the 50% of absorbance, 40%, 30%, 25%, 20%, 15%, 10%, 5%, 3% or 1%. In yet another embodiment, the average transmission of the blue light wavelength range of choice described in the system of activation Rate be activate system in visible spectrum on the 50% of average transmittance, 40%, 30%, 25%, in 20%, 15%, 10%, 5%, 3% or 1% so that the system of activation is at visible ray Substantially uniform optical filtering is provided in spectrum.It is not bound by theory, it is believed that the color of light color lens is put down Weighing apparatus (such as, white light transmittant and/or the CIE of yellow colour index) may be by filtering extra blue light Substantially interfere with.By the average transmittance of the described blue light wavelength range of choice is remained substantially Constant, it is believed that color balance can be kept substantially.This embodiment is characterised by the face strengthened Color balance, the most still provides retina protection, and unrelated with external lighting conditions.

In one embodiment, in order to provide the photochromic blue light of the color balance with brilliance to stop System, selects photochromic parts and blue light stop member to come in the described blue light wavelength range of choice real The most substantially non additivity effect.This can be such as by selecting photochromic parts to make when activated Main filtration wavelength outside the described blue light wavelength range of choice realizes.By this way, The photochromic parts activated affect the average transmittance of the described blue light wavelength range of choice indistinctively. It is suitable for the exemplary photochromic dyes of this purpose to include stopping when activated and exceed about 400 Those of nm, 410nm, 420nm, 430nm, 440nm, 450nm or 460nm.? In another embodiment, photochromic dyes optionally stop than about 430nm, 440nm, 450 The wavelength that nm or 460nm is bigger.

Photochromic blue light barrier system can be used for realizing beneficial characteristics as above, including right Specific sensitivity, color balance, colour vision, photopic vision, scotopia and physiological rhythm.Therefore, at one In embodiment, photochromic blue light barrier system tests (FACT in contrast sensitivity^TMSinusoidal wave grating Test) in by contrast sensitivity improve at least about 0.1,0.25,0.3,0.5,0.7,1,1.25, 1.4, or1.5 point.In another embodiment, photochromic blue light barrier system have less than 50, 40, the Huang of 35,30,25,23,20,15,10,9,8,7,6,5,4,3,2 or 1 Colour index.In yet another embodiment, photochromic blue light barrier system by inactive system, When activation system or inactive and activation system transmission, there is (0.33 ± 0.05,0.33 ± 0.05) Or the CIE of (0.33 ± 0.02,0.33 ± 0.02).

Blue light stop member and photochromic can be prepared according to any method being known in the art Parts, the method includes such as being applied by dyestuff or being impregnated in polymer matrix film.Blue light stops Each of parts and photochromic parts can have an independent existence in system or system local, example As, in annular or periphery.Each parts can exist as independent layer.Blue light Stop member can with light chromatograph physical contact or isolation (such as, by barrier layer or other Between ophthalmic components separate).Blue light stop member can be as the same after photochromic parts or vice versa. In another embodiment, blue light stop member and the mixing of photochromic parts, and cover single In substrate or coating.

Blue light stop member can exist with following concentration: about 1ppm to about 50ppm, big About 1ppm is to about 20ppm, about 1ppm to about 10ppm, about 1ppm to about 5 Ppm, about 2ppm to about 10ppm or about 1ppm, 2ppm, 3ppm, 4ppm, 5 ppm、6ppm、7ppm、8ppm、9ppm、10ppm、12ppm、15ppm、17ppm、 The concentration of 20ppm, 25ppm, 30ppm, 35ppm or 50ppm.These concentration are for two The embedding benzene and its derivative of naphthalene is effective especially, but one of ordinary skilled in the art can be by suitable When concentration be applicable to different blue light and stop dyestuff.

The disclosure of all lists of references as above and announcement is overall and clear and definite by quoting it It is incorporated to, reaches as being incorporated to each identical degree by being individually recited.

One of ordinary skilled in the art is it will be appreciated that according to the various modifications and changes of the disclosure It is apparent from, and is intended to fall under in scope of the following claims and spirit.Under by The indefiniteness example in face further describes specific embodiment.

Example

Example 1: manufacture the polycarbonate lens with the film integrated, film has the blue light resistance of change Gear dye strength, and measure the transmission spectrum of each lens, as shown in Figure 45.Use 2.2 The perylene of 35,15,7.6 and 3.8ppm (by weight) at the lens thickness of mm is dense Degree.The various tolerance calculated for each lens are shown in table iv, wherein, with reference to corresponding Reference in Figure 45.Because of according to Baeyer (Beer) law, the selective absorbing rate of light Depend primarily on the product of dye strength and coating layer thickness, it is believed that can use hard conating and/ Or primer coating combines with film or alternative membrane is to realize suitable result.

Table V

In addition to the lens of 35ppm dyeing, at all lens bags described in Table IV and Figure 45 Include the UV dyestuff generally used in ophthalmic lens system, so that UV wavelength is limited in 380nm Under.Photopic vision ratio describes normal vision, and is calculated as filter lens transmission spectrum and V λ The integration of (photopic vision sensitivity) is divided by the integration of unfiltered light He this same sensitivity curve. Scotopia ratio describes the vision under the conditions of poorly lit, and is calculated as filter lens transmission spectrum And long-pending divided by unfiltered light and this same sensitivity curve of the integration of V ' λ (scotopia sensitivity) Point.Physiological rhythm ratio describes the light impact for physiological rhythm, and is calculated as filtering The integration of mirror transmission spectrum and M ' λ (melatonin suppression sensitivity) divided by unfiltered light and this The integration of same sensitivity curve.Phototoxicity ratio describes by being exposed to what high-energy light caused For the infringement of glasses, and it is calculated as filter lens transmission spectrum and B λ (Phakic UV indigo plant Phototoxicity) integration divided by the integration of unfiltered light He this same sensitivity curve.Based on by Calculate the receptance function of these values corresponding to be disclosed below those: Mainster and Sparrow The Br.J.Ophthalmol of 2003 volume 87 1523-29 page " IOL should transmission the most blue Light？(How Much Blue Light Should an IOL Transmit？)》；Mainster exists In the Arch.Ophthal of 2005 volume 123 page 550 " intraocular lens should stop UV Radiation and purple light rather than blue light (Intraocular Lenses Should Block UV Radiation and Violet but not Blue Light)》；And Mainster was at the Br.J. of 2006 " purple light and the blue light stop intraocular lens: illumination is protected of Ophthalmol volume 90 784-9 page Method and photoreception (Violet and Blue Light Blocking Intraocular Lenses: Photoprotection vs.Photoreception)》.Applying for some, different light poison is bent Line is suitable, but computational methods are identical.Such as, for intraocular lens (IOL) Application, it should use aphakia light poison curve.And, when the understanding to phototoxicity light mechanism During raising, new light poison curve can be suitable for.

As described above shown in example data, the system according to the present invention can be optionally Suppression blue light, the specifically light in 400nm 460nm region, still carry simultaneously For the photopic vision luminous transmittance (photopic luminous transmission) of at least about 85% and little In the light poison ratio of about 80%, this light poison ratio is preferably less than about 70%, more preferably Less than about 60%, and preferably less than about 50%.As mentioned above, it is also possible to use This described technology realizes the photopic vision luminous transmittance of up to 95% or bigger.

Principle described herein can be applied to different luminous body, filter lens and skin colors, Target be filter poison blue light certain part, reduce simultaneously pupil dilation, scotopia sensitivity, By the cross-color of Ophthalmoligic instrument and the sight of the people wearing this device from viewing at their face The aesthetic feeling color of the outside Ophthalmoligic instrument from the point of view of the person of examining.

It is specifically illustrating at this and/or describes several embodiments of the present invention.It is understood, however, that In the case of without departing from the spirit of the present invention and the scope of intention, at the model of claims In enclosing, the modifications and changes of the present invention are contained in teaching above.Such as, although used spy The example determining dyestuff, dielectric optical filter lens, skin color and luminous body describes in this institute The method and system stated, it can be seen that the dyestuff that can make to be replaced with, filter lens, skin Skin color and luminous body.And, term as used herein " a " or " an " represent one or many Individual, it is odd number unless specified.

Example 2: use the dyestuff of 1X and 2X for as the transparent filter mirror of tester Concentration is come 9 patient's test comparison sensitivity.(FACT is tested according to contrast sensitivity^TMJust String ripple grating test), the contrast sensitivity that 7 display entirety in 9 patients is improved.It is shown in Table VI:

Claims (24)

1. an ophthalmic system, including:

At least one blue light stop member and at least one photochromic parts, described photochromic parts have State of activation and disabled state,

Wherein, described ophthalmic system includes ophthalmic lens；

Wherein, when described photochromic parts are in disabled state, described blue light stop member is even The 5% to 50% of the light of continuous ground and optionally filtration 420nm to 440nm wave-length coverage, and

Described ophthalmic system has at least 80% visible ray average transmittance；

Wherein, described photochromic parts are activated by least one in visible ray and infrared wavelength；

Wherein, described photochromic parts filter when being activated and include described 420nm to 440nm wavelength The visible ray of the wavelength outside scope；And

Wherein said blue light stop member and described photochromic parts are configured to, when described photochromic portion When part is active, the described range of choice realizes non additivity effect.

System the most according to claim 1, wherein, described blue light stop member is following One of: pectination filter lens, interference filter, bandpass filter mirror, band resistance filter lens, trap filter Light microscopic or dichroic filter or dielectric stack.

System the most according to claim 1, wherein, described blue light stop member is to present Go out and absorb and/or reflect and/or the organic or inorganic compound of interference with blue light wavelengths.

System the most according to claim 1, wherein, described blue light stop member is counnter attack Penetrate (AR) coating.

System the most according to claim 1, wherein, described blue light stop member is a kind of Or multiple porphyrin dye or derivatives of porphyrin.

System the most according to claim 1, wherein, described blue light stop member is integrated In PVA or PVB film.

System the most according to claim 1, wherein, in disabled state, described system System has the yellow colour index of no more than 10.

System the most according to claim 1, wherein, in disabled state, described system System has the yellow colour index of no more than 7.

System the most according to claim 1, wherein, in disabled state, described system System has the yellow colour index of no more than 5.

System the most according to claim 1, wherein, can in the system of described activation See that average transmittance spectrally is than the average transmittance on visible spectrum in sluggish system Little at least 20%.

11. systems according to claim 1, farther include UV filter lens.

12. systems according to claim 1, wherein, described system is ophthalmic lens, eye Mirror lens, contact lens, intraocular lens, corneal inlay, cornea cover or electrically activate thoroughly Mirror.

13. systems according to claim 1, wherein, described photochromic parts and described blue light At least one stopped is present in described system.

14. systems according to claim 1, wherein, described blue light stop member not with institute State the contact of photochromic component physical.

15. systems according to claim 1, wherein, described blue light stop member and institute State the mixing of photochromic parts.

16. systems according to claim 1, wherein, in disabled state, described System has the yellow colour index of no more than 15.

17. systems according to claim 1, wherein, described blue light stop member selects Property ground filter at least 10% of light in described 420nm to 440nm wave-length coverage.

18. systems according to claim 1, wherein said photochromic parts are activated by blue light.

19. systems according to claim 1, wherein said photochromic parts are swashed by visible ray Live.

20. systems according to claim 1, wherein said photochromic parts are swashed by infrared light Live.

21. systems according to claim 1, described in wherein in described state of activation The average transmittance of the light of 420nm to 440nm wave-length coverage is less than in described disabled state The average transmittance of light of described 420nm to 440nm wave-length coverage.

22. systems according to claim 1, wherein said blue light stop member is described Before photochromic parts.

23. systems according to claim 15, wherein said ophthalmic system includes coating, And wherein, described blue light stop member and described photochromic parts mix in described coating.

24. systems according to claim 15, wherein said ophthalmic system includes substrate, And wherein, described blue light stop member and described photochromic parts mix in described substrate.