CN104376659A - 多模式通信可摄取事件标记和系统,及使用其的方法 - Google Patents

多模式通信可摄取事件标记和系统,及使用其的方法 Download PDF

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CN104376659A
CN104376659A CN201410482175.0A CN201410482175A CN104376659A CN 104376659 A CN104376659 A CN 104376659A CN 201410482175 A CN201410482175 A CN 201410482175A CN 104376659 A CN104376659 A CN 104376659A
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CN104376659B (zh
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T.罗伯森
M.J.兹德布利克
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Otsuka Pharmaceutical Co Ltd
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Proteus Biomedical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00011—Operational features of endoscopes characterised by signal transmission
    • A61B1/00016—Operational features of endoscopes characterised by signal transmission using wireless means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
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    • A61B5/4833—Assessment of subject's compliance to treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861—Capsules, e.g. for swallowing or implanting
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
    • G06K7/10—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
    • G06K7/10009—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves
    • G06K7/10297—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves arrangements for handling protocols designed for non-contact record carriers such as RFIDs NFCs, e.g. ISO/IEC 14443 and 18092
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/162—Capsule shaped sensor housings, e.g. for swallowing or implantation

Abstract

本发明的各方面包括多模式通信可摄取事件标记设备。本发明的可摄取事件标记设备包括含导电通信模块和至少一个附加的非导电通信模块的可摄取的部件。非导电通信模块可以被与可摄取的部件集成，或者至少一部分或全部非导电通信模块可以被与可摄取事件标记设备的封装部件相关联。本发明的附加方面包括系统及使用该系统的方法，该系统包括该设备和一个或多个接收器。

Description

多模式通信可摄取事件标记和系统,及使用其的方法
本申请是申请日为2009年3月5日、申请号为200980116739.6、发明名称为“多模式通信可摄取事件标记和系统、及使用其的方法”的专利申请的分案申请。
相关申请的交叉引用
依照35 U.S.C.§119(e)，本申请主张2008年3月25日提交的申请号为61/034,085的美国临时专利申请的优先权；该临时专利申请的公开通过引用合并在此用于所有的目的。
简介
涉及药学产品的健康护理事务包括供应链问题、药房误差及效率差、涉及患者和/或药品的信息的无意识公开、及患者错用或滥用药物。仍然存在对安全、经济有效、复杂的解决方法的长期需要，以维护药品并保护患者免受这些围绕药品问题的后果。
发明内容
本发明的多个方面包括多模式通信可摄取事件标记(ingestibleevent marker)设备。多模式通信可摄取事件标记设备包括可摄取的部件(ingestible component)以及至少第二非导电(non-conductive)通信模块；该可摄取的部件包括包含导电(conductive)通信模块的集成电路，该第二非导电通信模块可以与可摄取的部件或其封装部件相关联。通信模块可以在不同的组合和配置中包括天线、集成电路、和/或相关部件。通信单元的各种配置组合或分离部件构成通信模块，例如天线，电源，或者集成电路，以达到设计目标的范围。此外，设备可以与各种其它设备进行通信，包括与存货清单(inventory)控制，药房控制，和体内和体间设备相关联的发送器/接收器。
本发明的其它方面包括可以横跨多个和各种应用被使用的系统，以在可摄取事件标记的存在的整个时期提供各种好处。例如，本发明的系统可以提供关于药物生产和封装管理操作以及供应链控制的存货清单控制信息。本发明的系统还可以提供关于药房的质量控制措施和有关药品、药品封装和患者历史的个性化应用。本发明的系统还可以提供患者安全信息以及安全控制措施。本发明的一些系统可以依照预设或动态可更新的控制功能，提供和/或隐瞒与系统相关联的数据。
相应的，本发明的各方面包括包含可摄取的部件的设备，该可摄取的部件包括包含导电通信模块的集成电路；和第二非导电通信模块。在某些示例中，第二非导电通信模块包含至少选自由无线射频模块、磁感应模块、光学模块、听觉模块和有线模块构成的组的模块。在某些示例中，非导电通信模块是包括无线射频识别模块的无线射频模块。有其它示例中，非导电通信模块可以是红外线频率模块。可摄取的部件可以包括电源，比如由一对用不同材料制作的电极构成的电源。可摄取事件标记设备还可以包括电性耦合到非导电通信模块的第二电源，比如线圈，例如RFID线圈。在某些示例中，可摄取的部件包括非导电通信模块。在这种示例中，非导电通信模块可以电性耦合到可摄取的部件的集成电路，即可摄取的部件集成电路。在这种示例中，可摄取的部件集成电路、导电通信模块和至少非导电通信模块的一部分可以集成到可摄取事件标记识别器部件中。在某些示例中，非导电通信模块包括非导电发送器，比如RF天线，例如RF天线线圈，其可以与可摄取的部件相关联，比如与套筒部件，或者可以与设备的封装部件相关联。在某些示例中，非导电通信模块被电性耦合到不同于可摄取的部件集成电路的第二集成电路。在存在时，该第二集成电路和可摄取的部件集成电路可以被配置为相互通信。在某些示例中，至少非导电通信设备的一部分被配置为以不损害导电通信模块的功能的方式从可摄取的部件分离。可摄取的部件可以包含活性药学物质，其物质可以出现在生理可接受的载体中和/或可摄取事件标记的套筒部件中。在某些示例中，生理可接受的载体可以被配置为药片或胶囊。
本发明的其它方面包含多个系统，该系统包括：包括包含被配置为发出第一信号的导电通信模块的集成电路的可摄取的部件；配置为发出第二信号的第二非导电通信模块；和接收器。在这些系统中，接收器、导电通信模块和非导电通信模块可以被配置为提供在接收器和导电通信模块与非导电通信模块中至少一个之间的信息传输。在某些示例中，接收器被配置为接收第一信号和第二信号中的至少一个。第一和第二信号中的任何一个都可以按照所期望的来加密，例如，通过使用任何方便的加密协议。在接收器被配置为接收第二信号的地方，在某些示例中，接收器包括射频阅读器。如期望的，接收器可以被配置为向非导电通信模块传送信息。在系统的一些示例中，接收器是选择自从由生产系统、供应链管理系统和健康护理管理(例如药房)系统构成的组所选择的系统的部件。可包括在此描述的接收器的生产系统部件包括分类器、编程器、编码器等。可包括此描述的接收器的供应链管理系统部件包括跟踪器和编程器。可包括在此描述的接收器的健康护理管理系统包括扫描器、编码器等等。在某些示例中，系统的接收器被配置为第一信号，该第一信号可包含非生理性数据。接收器可以被配置为例如通过粘合部件可移动地附接到生物。可替代地，接收器可以是可植入接收器。在期望的地方，可植入接收器可以包括附加的功能，例如电性刺激功能、生理数据测量功能等。
本发明的各方面进一步包括不同的方法，比如检测来自设备的第一信号和第二信号中的至少一个，其中所述设备包括含包括被配置为发出第一信号的导电通信模块的集成电路的可摄取的部件；以及被配置为发出第二信号的第二非导电通信模块的至少一部分。该方法可以包括只检测第一或第二信号，或者第一和第二信号两者。附加的方法包括发出来自设备的第一信号或第二信号中的至少一个，所述设备包括包含包括被配置为发出第一信号的导电通信模块的集成电路的可摄取的部件；及被配置为发出第二信号的第二非导电通信模块的至少一部分。该方法可以包括只发出第一或第二信号，或者第一和第二信号两者。
本发明附加的方法包括在非导电通信模块和接收器之间传送信号，其中非导电通信模块是设备的部件，所述设备包括包含包括导电通信模块的集成电路的可摄取的部件；以及第二个非导电通信模块。在这样的方法中，接收器可以是选自于系统的部件，所述系统是从由生产系统、供应链管理系统和健康护理管理系统构成的组中所选择的。在接收器是生产系统的一个部件的地方，生产系统可以是一个高吞吐量生产系统。不管接收器是否是生产系统、供应链管理系统或健康管理系统的一个部件，该信号可以从设备被传送到接收器和/或从接收器传送到该设备。
本发明的附加方法包括将设备给与对象的方法，所述设备包括含包括被配置为发送第一信号的导电通信模块的集成电路的可摄取的部件；及被配置为发出第二信号的第二非导电通信模块的至少一部分。这些方法可以包括在接收器上接收第一信号，并且还可以进一步包括根据接收到的第一信号确定可摄取的部件的历史信息(例如谱系信息)。
在某些示例中，术语“生命周期(lifecycle)”被用来指本发明的设备和系统。“生命周期”包含了药学产品存在的时间，从生产延伸到消亡。这个时期包括，例如药品生产、供应链管理、药房管理、及患者拥有。生命周期还可以指药学产品存在的一个阶段，或者选择它的存在的多个阶段。
“医药(pharma)信息”和“药品数据”指的是关于药品及其使用的信息，包括与生产、供应链、药房存货清单和分发、患者识别数据、剂量指导及消费数据相关的信息。例如，由系统所使用的信息可以包括生产的日期、时间和地点，批量号，批号，药品名称，药品类型，制造商名称，药房名称，从药房出售给患者的日期和时间，摄取时间，排出时间。
如在公开的号为2007/0008112，2006/0061472和2005/0285732的美国专利申请中所讨论的用于药学跟踪的RFID系统的各方面，也可以被用在所述系统中并且据此以引用的方式将它们整体并入。
附图说明
图1A到1B示出了根据一个实施方式的可摄取事件标记识别器。
图2示出了根据一个实施方式的通信环境。
图3示出了根据一个实施方式的图2的系统。
图4示出了根据另一个实施方式的系统的剖面视图。
图5示出了根据一个实施方式的第一药丸通信系统的示意图。
图6示出了根据一个实施方式的第二药丸通信系统的示意图。
图7示出了根据一个实施方式的第三药丸通信系统的示意图。
图8A到8B示出了根据一个实施方式的第一RFID模块和第二RFID模块。
图9示出了根据一个实施方式的可摄取事件标记识别器，其包括导电通信模块和RFID通信模块。
图10示出了根据一个实施方式的IEM产品生命期流程图。
图11示出了根据一个实施方式的可被用在生产系统中的投放器(dispenser)。
图12示出了根据一个实施方式可使用图11的生产系统生产的容器。
图13提供了根据一个实施方式的IEM产品生命期流程图，并示意了可获得的信息的类型。
具体实施方式
如以上所概括的，本发明的多个方面包括多模式通信可摄取事件标记设备。本发明的可摄取事件标记设备包括可摄取的部件，该部件包括导电通信模块和至少一个附加的非导电通信模块。非导电通信模块可以与可摄取的部件集成，或者非导电通信模块的至少一部分或全部可以与可摄取事件标记设备的封装部件相关联。包括可摄取事件标记设备和接收器的本发明的系统可以被配置为横跨可摄取事件标记的整个生命周期提供药品信息和控制措施。生命周期例如包括药品生产、供应链管理、药房管理、和患者使用管理。
某些实施方式的可摄取事件标记设备可以包括可摄取的部件，该可摄取的部件包括包含导电通信模块(例如以被集成的识别器(identifier)形式出现)和至少第二非导电通信模块的集成电路部件，其中附加的非导电通信模块的数量可以是变化的，例如一个或更多、两个或更多、三个或更多、等等。相应地，本发明的可摄取事件标记设备可以被看作多模式通信可摄取事件标记设备，因为它们包括至少两个不同的通信模块，其中一个是导电通信模块。如上文所指出的，至少第二非导电通信模块可以与可摄取的部件相关联，或部分地或全部地与该设备的封装部件相关联，如果存在的话。如此，本发明的可摄取事件标记设备可以包括或不包括与可摄取的部件相关联的封装，其中封装可以被以诸如泡罩包装(blister pack)、多剂量容器等各种不同的形式配置。在某些示例中，通信模块与药品部件(当存在时)动态地相结合，从而获得高效且精确的信息以及从而以可行的、经济的方式来控制解决方案。例如，在一个实施方式中，通信模块被实现为药丸和/或药品封装的必需(integral)部分。进一步，系统可与各种其它设备通信，其包括与存货清单控制、药房控制、及体内和体间设备相关联的发送器/接收器。
如以上所概括的，本发明的设备和系统包括至少一个非导电通信模块。通过非导电通信模块意味着使用除使用体液作为导电的媒介的导电的通信协议以外的通信协议来进行通信的通信模块(例如，如在PCT所公开的公开号WO 2006/116718；WO 2008/008281；WO 2008/095183和WO 2008/063626的申请中所进一步描述的；在此将这些申请的公开通过引用并入)。关注的非导电通信协议(即模式)包括但不限于：无线射频模式；磁感应模式；光学模式，比如红外线频率光学模式；听觉模式；以及有线(wired)模式，即直接模式。相应的，在某些示例中，非导电通信模块可以至少是一个从由无线射频模块、磁感应模块、光学模块、听觉模块和有线模块所构成的组中所选择的模块。
在一些关注的实施方式中，非导电通信模块是无线射频模块。尽管无线射频通信模块可以变化，在某些示例中，这个模块是射频识别(RFID)模块。仅仅为了便于描述的目的，本发明的实施方式现在将进一步按照在其中非导电通信模块是RFID通信模块的实施方式来描述。然而，如上文所提到的，非导电通信模块可以广泛地变化。
在某些示例中，RFID模块合并了例如集成电路和RF天线。RFID模块可以与合并了例如集成电路和导电的天线的导电模块通信地相关联。RFID模块或导电模块，或两者，可以与药品和/或药品封装共同工作，以接收、处理、存储、和/或传送涉及药品或与药品相关联的信息。如上文所指出的，设备和系统可以被横跨多个和各种各样的应用来使用，从而以可行的、经济的实施方式来提供安全的，受控的和准确的通信。
广义地讲，设备和系统有助于信息通信和控制措施直到可摄取事件标记的整个生命周期。系统能够在各种通信环境中应用，尤其是在无线通信优先的环境中。例如，通信环境包括存货清单(inventory)控制环境以及体间和体内通信。
体间和体内通信包括例如与来自可植入、可摄取的、可插入、和可附接的医疗设备及与人体或其它生物体相关联的药品的数据传输和接收相关联的主动、被动及半被动系统。医疗设备能够与本发明的系统通信和/或集成。
如上所述，本发明的可摄取事件标记设备包括可摄取的部件，该可摄取的部件至少包括集成电路和导电通信模块。这种结构在此被共同称为可摄取事件标记，而可摄取事件标记可以也可以不包括附加的部件，比如生理可接受的载体(vehicle)和/或药学活性物质。相应的，在此所描述的、在本文中有时称为“IEM”的可摄取事件标记，至少包括可摄取的部件，该可摄取的部件包括包含导电通信模块的集成电路，其中该导电通信模块包括导电的发送器。集成电路和导电通信模块可以共同称为识别器。所关注的识别器是当可摄取事件标记识别器与目标生理位置(或多个位置)接触时，产生(例如发出)可检测的信号的结构。可摄取事件标记识别器可以根据特殊的实施方式和组成的预期应用发生变化，只要在接触比如腹部或小肠等目标生理位置时，将它们激活(打开)。如此，可摄取事件标记识别器可以是当其在一个目标地点被激活时(例如，当它与目标身体地点接触时)，发出信号的结构。可摄取事件标记识别器可以是能够随着激活提供可检测信号的任何部件或设备。根据本发明的实施方式，可摄取事件标记识别器包括信号生成部件。可摄取事件标记识别器可以被配置为，一旦该组成进入与生理目标地点接触，即发出信号。根据该实施方式，目标生理地点或位置可以变化，其中关注的具有代表性的目标生理地点包括但不限于：胃肠道中的位置，比如口、食管、胃、小肠、大肠等。可摄取事件标记识别器可以被配置为在目标地点与流体(例如胃液)相接触时，便被激活，而不管目标地点的特定组成。在期望的地方，可摄取事件标记识别器可以被配置为在组成与目标生理地点接触后，被询问(interrogation)激活。可摄取事件标记识别器可以被配置为在目标地点被激活，其中目标地点是在指定的时段之后到达的。
根据具体应用的需求，从可摄取事件标记识别器获得的信号可以是通用(generic)信号，使得该信号为仅识别出该组成已经与目标地点接触的信号。可替代地，信号也可以是唯一信号，比如以某种方式唯一地识别来自一组或多个不同的可摄取事件标记(例如一批可摄取事件标记)的特殊的可摄取事件标记，已经与目标生理地点接触。如此，可摄取事件标记识别器可以是这样的识别器，所发出的信号不能被与从中获得可摄取事件标记的一批中的任何其他可摄取事件标记成员的可摄取事件标记识别器所发出的信号区别开。可替代地，一批可摄取事件标记中的每个可摄取事件标记成员都可以具有发出唯一信号的可摄取事件标记识别器，至少相对于该批中的可摄取事件标记成员的所有其它可摄取事件标记识别器。可摄取事件标记识别器可以发出为全局唯一信号的唯一信号(其中这样的信号可以类似于人类指纹，其不同于任何其它个体的任何其它指纹，并且因此在全局的级别上唯一地识别出一个个体)。信号可以或直接传递关于给定事件的信息，或提供识别码，该识别被用来从数据库(比如将识别码与组成链接的数据库)中取回关于事件的信息。在需要的地方，信号可以以在对信号和其信息内容的访问上提供控制的方式被加密。
可摄取事件标记识别器至少生成导电(近场)信号，该信号通过使用体液作为导电的介质的导电通信协议被传送(例如，如在PCT所公开的公开号为WO2006/116718；WO2008/008281；WO2008/095183及WO2008/063626的申请中所进一步描述的那样；这些申请的公开在此以引用的方式并入)。根据给定的实施方式，可摄取事件标记识别器可以一次传送一个给定的信号。可替代地，可摄取事件标记识别器可以被配置为两次或更多次传送具有相同信息的信号(相同的多个信号)，其中该批不连续的相同的多个信号可以共同被称为冗余信号。
可摄取事件标记识别器可以根据具体实施方式和组成部分的预期应用而发生变化，只要它们在与比如腹部或小肠等目标生理位置接触时被激活(打开)。可摄取事件标记识别器可以包括激活部件和传送元件，该激活部件比如是由胃酸完成(complete)的电池。在这些实施方式中，识别器可以被看作包括“湿电池”电源，该电源至少为导电通信模块供电，以及可以给也可以不给非导电通信模块供电，正如以下进一步展开的一样。关注的不同类型的可摄取事件标记识别器的例子包括但不限于在以WO/2006/116718所公布的序列号为PCT/US2006/016370的PCT申请；以WO/2008/052136所公布的序列号PCT/US2007/082563的PCT申请；以WO/2008/063626所公布的序列号为PCT/US2007/024225的PCT申请；以WO/2008/066617所公布的序列号为PCT/US2007/022257的PCT申请；以WO/2008/095183所公布的序列号为PCT/US2008/052845的PCT申请；以WO/2008/101107所公布的序列号为PCT/US2008/053999的PCT申请；以WO/2008/112577所公布的序列号为PCT/US2008/056296的PCT申请；以WO/2008/112578所公布的序列号为PCT/US2008/056299的PCT申请；以及序列号为PCT/US2008/077753的PCT申请中所描述的那些可摄取事件标记识别器；在此通过引用的方式将这些PCT申请的公开并入。
关注的可摄取事件标记的例子被示意在图1A和1B中。图1A和1B中示出的可摄取事件标记10包括集成电路部件20(在此也被称为识别器)以及上部电极22和下部电极24，其中该上部和下部电极是由不同的材料制造的，并且被配置为使得在与胃液接触时，电流通过该集成电路，从而导致电路中一个或多个功能块发出可检测信号。图1A和1B中所示出的标记包括虚拟(virtual)偶极信号放大元件30(有时被称为“套筒(skirt)”)，如在序列号PCT/US20008/077753的PCT申请中所更详细描述的那样，该PCT申请的公开通过引用在此被并入。
在一个例子中，IEM包括导电的天线，导电的调制器和湿电池。消化系统液体例如激活用作各种可摄取事件标记部件的电源的电池。检测事件通过液体接触发生。数据被通过导电的天线传送到接收设备。
可摄取事件标记设备可以与被配置以接收由可摄取事件标记的导电通信模块所发出的导电信号的接收器共同使用。可附接的医疗设备的一个例子是发送器/接收器(其在此可以被称为Raisin接收器)永久地与身体相关联(例如植入身体中)或者可移动地附接到身体的外部。关注的接收器包括，但不限于，在PCT所公开的公开号为WO2006/116718；WO 2008/008281；WO 2008/095183和WO 2008/063626的申请中所描述的被配置以检测导电地传送的信号的那些接收器；这些PCT申请的公开在此通过引用的方式并入。照此，IEM可以与发送和/或接收设备(比如，前文提到的Raisin)通信地相关联。该发送/接收设备包括体内设备，可移除地或永久地附接到身体的外部设备，及远程设备、即未与身体物理地相关联但能够与可摄取事件标记通信的设备。
所述设备和系统的不同实施方式，包括实现通信的(communication-enabled)药丸和封装，实现了对IEM和其任何药品的识别(如果存在的话)。下文所用的“药丸”是任何实现通信的药品的代表。IEM封装包括，例如能够容纳单个IEM(例如药丸或有限数量的药丸或胶囊)的“泡罩”包装。IEM封装进一步包括与药品相关联的容器，盒子，包装纸(wrapping)，IV包，等等。
在不同的实施方式中，通信部件可以是独立于(sovereign)药丸的。在其它实施方式中，通信部件可以是分布式的，例如RF模块或其部分与封装物理地相关联，而导电通信模块与可摄取的部件(比如药丸或胶囊)物理地相关联。例如，当药丸由于RFID模块部件与设备的其余部分的物理分离而被从封装中移除时，RFID通信可被中断。在一个实施方式中，RFID天线被置于药品封装上，并通过“阶跃(snap-off)”机制与设备的其余部分分开，由此一旦已经将它从封装上移除，就可以阻止RF与可摄取的部件通信。在另一个实施方式中，在药房将IEM交付给患者时，RFID天线被移除。在以上例子中，其它的RFID模块部件，比如数据存储部件，可以以这样的方式与RF天线相关联，即它们随天线一起与系统的其余部分分离。可替代地，当RFID模块的另一部分与药丸分离时，RF天线可能保持与药丸附接。如此，在某些示例中，非导电通信模块的至少一部分被配置为，以不损害导电通信模块的功能的方式，从可摄取的部件分离。以这样的方式将RFID模块的部分或者全部从导电通信模块分离的一个优点是，由RFID通信的中断所给予的患者隐私的保护。
在一些实施方式中，在RFID系统上或被写入到RFID系统的可读数据的一些或全部，将是通过将RFID模块从导电模块的切断而可移除的，以此来保护患者隐私。然而，在其它的实施方式中，鉴于长期跟踪和/或识别的目的，这样的数据的保留在分开之后可能是所期望的。
RFID部件可以被用来通过比如药品识别信息、剂量信息、批号和批量号、及过期日期等各种数据来编码药丸或者药品封装。这些数据可以以任何方式被处理从而优化功能。例如，质量控制过程可以读取每一个IEM的信息，并聚集与最佳存货清单、运输跟踪和财政过程相一致的信息。自动分类器能够与每一个IEM通信，以高效地处理、分类、及封装药品。
类似地，运输操作可以被跟踪和控制，以确保肯定的(positive)药品识别、药品位置等等。在一个例子中，一旦药品分发开始，所述设备和系统可以被用来检查仿冒的药品，比如从国际点(international point)或从其它缺少好的监察实践的地方所收到的药品。
药房操作可以因使用该设备和系统而被优化。例如，在将药品收到药房内后，药房工作人员即可以扫描药品封装和药品，以确保收到期望的产品及确保药品的认证。在将药品分发给患者之前，药房可以根据关于患者的信息对药品封装、容器、和单个药品进行编码。例如，这些信息包括患者身份证明、药品身份证明和特定患者的剂量和过期信息。进一步的信息包括禁忌药品、警告等等。如此，药品的历史、可追溯性、效能和安全性被解决。
此外，该设备的不同实施方式可以与关注的系统中的分发设备配合动作。例如，一旦药品信息被读入到系统中，分发设备将各种药品收集到一个容器或甚至单个IEM或剂型(formulation)中，用于特定患者。
在不同的实施方式中，所述设备可以是很小的，小范围单元。单个药丸通过的非常大的比如RFID棒或门等RF检测器，例如在某些图中描述的漏斗，可以被用来与体外的设备通信，例如在100μm到10米的范围内，如3μm到3厘米，例如近似1厘米。然而一旦被摄取之后，RFID通信模块的小范围不便于与随机设备进行通信，即那些非预期或授权与IEM进行通信的设备。如此，与IEM相关联的关于非授权或无意识的信息的通信的隐私担忧被最小化。较大范围RFID设备，即，作用范围1米到20米，比如1米到3米，例如2米，可以用于一些跟踪应用。在这种应用中，隐私保护可以通过如上面所描述的RFID和导电通信模块的分离来提供。可替代地，可以通过使用适当的加密技术，在这种及任何特殊的通信中提供隐私，使得在隐私考虑是所担心的地方的关注的任何信号都被加密。任何方便的加密协议都可以使用。
还可以选择RFID模块工作的频率范围，以实现不同的设计目标。当设备被患者使用时，低频RF(即Hz/kHz范围内的无线电波)，例如5kHz到500kHz之间(如125kHz)，可以优选用于通信。然而，MHz/GHz范围的RF，例如1MHz到1GHz范围内(如13.56MHz)，在患者使用之前，可有助于系统的跟踪。多个RFID模块能被组合在一个系统中从而有助于这些不同的需求。
一旦IEM到达患者环境，与IEM相关联的信息可以被用于不同目的。例如，IEM可以与IEM容器和与接收器(比如在前的Raisin)相互协作，以确保试图打开IEM容器的人确实是被指定的人。进一步的通信活动包括信息控制系统，其中与IEM设备相关联的药品信息和从一个或多个源所接收到的患者数据进行比较，以确定例如药品是否是禁止的，是否服从剂量和时间、或其它事件和/或条件。
当患者摄取之后，由IEM所保存的信息可以从一个或更多的通信模块中重新获得(recover)。例如，通信功能可在摄取之后通过导电通信部件执行，例如使用可摄取事件标记和Raisin接收器。在一些实施方式中，具有有限的RF范围的设备维护关于由系统所保存的信息的患者隐私。系统的其它实施方式提供RFID模块部件的分离，以防止对设备的RF访问。
数据可以被存储在设备中，并在每次交易中用安全数字签名重新编程。
当患者排出IEM发生时，各种实施方式允许与比如传感器等设备的通信，以确定例如，与患者或药品相关的数据、或者通过身体的传送时间。可替代地，在不同的实施方式中，数据在排出之后被擦除(或者各种与数据相关联的部件/子部件被破坏或从系统中分离)以保护隐私担忧。
图2中示出了根据一个实施方式的包括可摄取事件标记设备102的通信环境100，其包括导电通信模块和RFID模块两者。设备102的RFID模块通过通信链路104，与被配置为接收来自所述设备的导电通信模块或RFID通信模块中的至少一个的信号的接收器互相配合。例如，接收器106可以是RFID棒106。在通信环境100中，设备102与RFID棒106互相配合，例如，从RFID棒106引进电源。RFID棒106例如以射频工作，并发送数据到设备102和/或从设备102接收数据。如此，可以实现通信而不依赖液体接触来激活电源。此外，在某些实施方式中，设备102由相关联的通信设备(例如RFID棒106)的射频信号供电。如此，设备102有总体相对小的尺寸，从而有助于缓解与身体有关的摄取、植入、维护、及往返移动动作(traversal activity)。
更具体地，图3示出了根据一种实施方式的图1的可摄取事件标记设备102。设备102包括药丸202和通信模块204。该通信模块包括集成电路(“芯片”)206，RF天线208，导线(一个或更多)210，和天线套筒212。药丸202可以有不同的药学配置(pharmaceutical configuration)，如胶囊、胶囊药片(caplet)、软胶囊(gel caps)、固体药丸、药片和其它类型的药丸药品。药丸202可以包括生理可接收的载体，并且可以进一步包括也可以不包括药学活性物质。芯片206是永久或可移动地粘贴到药丸202的至少一部分，或者与药丸202的至少一部分集成。芯片206包括各种部件/子部件(未示出)的组合。例如，芯片206可以包括或者否则与存储器、处理器、存储单元、发送器和/或接收器，或与数据处理、存储器、传输和接收相关联的其它部件相关联。
RF天线208经由导线210永久或可移动地附接到芯片206，或者反之经由导线210与芯片206通信。在不同的实施方式中，天线210被与天线套筒212(在上文中也称为虚拟偶极信号放大器)集成，或相反与天线套筒212相关联。在不同的实施方式中，天线套筒212可以是挠性的、非挠性的、可折叠的、不可折叠的、可卷绕的、不可卷绕的、可伸展的或反之受控的。如此，被折叠的天线套筒212有助于摄取/植入，然而在身体中伸展以促进通信传输和接收。天线套筒能被实现在不同的材料或材料组合中，只要在此所描述的功能能够被执行。
图4示出了根据另一实施方式的可摄取事件标记设备300的截面视图。可摄取事件标记300包括封装302，如“泡罩”包装。设备300的芯片206包括RFID通信模块，该RFID通信模块通过导线210电耦合到RF天线208。RF天线208可以被集成到封装302内，或者以任何与封装302相关联的形式形成。芯片206可以被放置在泡罩包装，或者与任一泡罩包装相关联，例如，其中独立的通信地相关联的芯片可被附接到泡罩包装及药丸。可替代地，芯片206可以是比如药丸等可摄取的部件(未示出)的一部分，比如其中芯片206进一步包括导电通信模块。与泡罩包装相关联的通信可以实现，而不需要使所有的板载RFID部件为可摄取的部件，这样为整个RFID通信的摄取提供了替代方案。因此，RFID板外部件，即没有与可摄取的部件物理地相关联的部件，不必由可食用材料组成。
如以下所解释的，RFID通信部件204可能不同程度地与IEM的导电部件相关联。例如，图5示出了第一药丸通信系统400的示意图，有时也被称为“发送器”，包括由感应电源402供电的RF天线208。感应电源402包括例如RFID棒106(在图2中示出)。RF天线208与第一调制器404通信地相关联，其调制与数据406相关的信号，所述数据可以被存储在例如存储器(未示出)或者其它媒介中。
药丸通信系统400进一步包括由湿电池410供电的导电的天线408。湿电池410被例如消化液激活。导电的天线408与第二调制器412通信地相关联，第二调制器412调制与导电的天线408相关联的信号。第二调制器412与数据406通信地相关联，所述数据406可以被关联到例如存储器(未示出)或其它媒介。如此，一般数据例如数据406可以由两种不同的链路传送，这取决于所期望的功能。
例如，数据在生产、运输、药房、和家庭操作过程中，可以通过RF天线208被调制并发送。在摄取药丸之后，相同的(或不同的)数据能通过导电的天线408被发送。在不同的实施方式中，在从身体排出之后，排出的时间可以被确定并被用来例如计算通过身体的总的传送时间。
在一些实施方式中，在系统中所存储的数据的一些或全部可以被擦除、破坏等。例如，药丸包括可熔断链接(未示出)，并将一部分电力用来从存储器完全地擦除数据，或物理地破坏存储器。例如，当导电通信模块电源(例如湿电池)被激活时，所提供的电力触发数据删除。如此，如果药丸被回收，没有可以通过未被授权的源取回的数据，而患者的隐私权益受到保护。将数据分离到独立的模块中(未示出)还允许一部分存储的数据被删除，例如患者或剂量信息，同时允许一部分数据保留下来，例如药品识别信息。
由RFID通信模块的部分和导电通信模块之间的分离所提供的另外的优点是获得存储在药丸上的数据的故障保险机制。也就是，如果一个通信模块出现故障，其它模块保持可用，从而有助于通信。例如，如果一个或多个导电通信模块部件停止工作，RFID棒106(示意在图2中)可以用于感应地给药丸通信系统400供电，以从数据406获得信息。
此外，将导电通信模块从RFID通信模块部件分离，有助于通过如在前所描述的“阶跃”机制，将系统的一部分物理禁用。
图6示出了根据一个实施方式，第二药丸通信系统500的示意图。第二药丸通信系统包括螺旋导电的RF天线502，RF调制器404，导电的调制器412和数据406。天线与由感应电源供电的RF调制器404通信地相关联。RF调制器404调制与天线相关联的信号。RF调制器404与数据406通信地相关联，数据406可以例如关联到存储器(未示出)或其它媒介。天线502进一步与由例如湿电池供电的导电的调制器412通信地相关联。导电的调制器调制与天线相关联的信号。导电的调制器与数据406通信地相关联，数据406可以被关联到例如存储器(未示出)或其它媒介。如此，第二药丸通信系统容纳与单个天线相关联的信号的RF调制和导电。以有助于导电和RF通信两者的单个天线为特征的IEM设备，将潜在地减少与整个系统相关联的部件、设计、和测试费用。此外，故障模式因部件从系统中被移除而减少。当系统包括一个天线而不是两个时，天线故障的可能性也被减少。
图7示出了根据一个实施方式，第三药丸通信系统600的示意图。第三药丸通信系统600包括天线502，调制器602和数据406。调制器602调制来自天线502的信号，并且可由一个或多个源(例如湿电池和/或感应电源)供电。在一个实施方式中，例如，调制器504是125千赫兹(KHz)的调制器。在其它例子中，调制器是13兆赫兹(KHz)或其它频率波段的调制器。如此，第二药丸通信系统500在单个调制器/天线设计中容纳感应和导电电源两者，这允许在多个通信环境中的多种类型通信。因系统中部件数量的进一步减少而进一步实现了如在上文的图5中所示意的部件集成的优点。
图8A和8B示出了根据一个实施方式的第一RFID模块602和第二RFID模块604。第一RFID模块602被配置与小芯片606(集成电路或挠性电极)有关。小芯片606，例如，在一侧上是在10微米和10毫米之间，如100微米到5毫米，例如在一侧为1毫米，其在第一侧(未示出)上具有阴极而在第二侧(未示出)上具有阳极。芯片606被嵌在套筒608中，由调制电流通过套筒608产生导电传输。天线504沿着芯片606的边沿延伸(run)，即被关联到芯片606的边沿。天线504包括，例如，用作用于RFID链接的天线的多圈/多层天线。在一个实施方式中，天线相对小。在不同的实施方式中，在天线504上引入了绝缘层(未示出)以扩展范围。例如，该绝缘层包括天线504上的数百微米塑料。如此，药学RFID单元602是紧凑的，因此在可接受的通信范围内仍然可操作的同时，易于摄取/植入。在不同的其它实施方式中，天线504匹配身体的折射率。如此，RFID天线有助于体内、体间和体外通信。
第二RFID模块604被配置为与小芯片606有关，在芯片606的顶部具有阴极层(未示出)。金属层被以天线504图案化，例如，以具有多圈的、螺旋形设计的天线504密集地图案化。金属层在那里有切口(slit cut)，如单个螺旋切口。当阴极材料被沉积时，天线504用作导体，其提供基底以附接阴极的并且还提供电流收集器以便从它提取电能。如此，天线504在湿时变短，从而允许RFID模块在干燥的环境(生产，药房等)中但非液体环境中(例如在体内)工作。这样通过使RFID在其处于体内时与生命周期医药(pharma)信息系统的通信禁用来促进隐私保护。
在各种实施方式中，根据与生命周期医药信息系统相应的任何图案(pattern)和/或位置来配置天线504。该图案包括，例如，螺旋、波形曲线、曲线、多圈的、直的、曲线的、单层、多层和其它设计及设计的组合。
图9给出了根据实施方式的包括RFID通信模块的可摄取事件标记识别器。在图9中，IEM识别器900包括集成电路部件910和套筒920。集成电路部件910包括导电通信模块和RFID通信模块。识别器910还包括RFID天线930。
包括导电通信模块和非导电通信模块两者的IEM识别器，比如RFID通信模块，发现用在各种不同的应用中，其可长达(span)可摄取事件标记的产品生命期(lifetime)。由这样的识别器提供的能力和功能包括，但不限于：在IEM生产阶段、供应链阶段、药房管理阶段、和患者使用阶段的一个或多个处，读取IEM识别器信息并存储谱系信息。给定IEM的完整谱系，从生产商到使用和/或处理(disposal)，可以很容易地获得。可以在供应链中的每一个点提供审核(audit)能力。根据需要，可以采用自动分类门和加密签名来验证产品的真实性。
使用任何方便的生产协议可以制造包括导电通信和非导电通信模块两者的IEM设备。在某些示例中，所采用的生产协议是高吞吐量(high-throughput)生产协议。这种高吞吐量生产协议包括，但不限于，在序列号为61/142,849的美国临时申请中所描述的那些，在此将该申请的公开以引用的形式并入。一种高吞吐量生产协议以示意图的形式示意在图10中，在该高吞吐量生产协议中，IEM包括具有导电和RFID通信模块两者的识别器以及包括活性药学物质的药片生理可接受载体。图10中所示意的过程1000始于包括导电和RFID通信模块(如图中9示意的识别器)的IEM识别器1010正被与活性药学物质(API)和生理可接受载体1020结合到在阶段1030的药片IEM中。在药片压缩后，产生的药片可在阶段1040被涂层并且任何打印或贴标签可以被应用在阶段1050，以产生最终的IEM。接下来，IEM被送到成批封装(bulk package)阶段1060，其中IEM的最终成批包装在阶段1070被运送到药房1080，以便最终出售给顾客。框1090示意了该过程中RFID通信模块在其处可被用于发送信息到IEM和/或从IEM接收信息的点的例子。例如，编程信息可以在1092、1094、1096和1098中的任何点，通过RFID通信模块，被传送给IEM。可替代地和/或除了通过RFID通信模块在1092、1094、1096和1098中的任何点处传送编程信息到IEM之外，还可以在这些点的任何一个处从IEM取回识别信息，从而例如，有助于封装、分类、处理等。
图11提供了包括RFID接收器/发送器的分类器设备的视图，其中该分类器设备可以被用在生产、和供应链和/或药房系统(例如在1092，1094，1096和1098中的任何一点处)。在图11中，给料斗1100包括大量的IEM 1110，其中IEM包括导电和RFID通信模块，比如图9中所示的IEM。漏斗1120分发IEM到药剂师柜台1130内。药剂师柜台1130包括用于RFID通信的1个、2个或3个线圈1135(其中图中给出了3个)。药剂师柜台包括管1137，其确保一次分发单个IEM到容器1140中。容器1140充满了已识别和已分类的IEM。
图12中示出了容器1140的实施方式的例子。图12中的容器1140包括许多已经被系统1110识别过的IEM 1110。容器还包括RFID标签，1150和条码1160。同样被示出的是盖1170。系统1100和容器1140可以与信息系统一起被使用，以便容易地知道容器的确切内容，其包括在容器中出现的每一个IEM的谱系信息。
图13提供了IEM产品生命期的流程图并提供了由包括导电和非导电通信模块两者的IEM设备所产生的多类信息的例子。在图13中，来自原料供应商1300的原料被送到工厂1310，用于IEM的生产。分配器1315和1320将IEM从工厂转到药房，比如医院药房1330或零售药房1335，并最终到患者1340。非导电通信信息在患者摄取之前可以被用于，连同其它动作一起，提供制造厂1310和第一分配器1315产品认证，提供第一分配器1315和第二分配器1320之间已验证的产品，在药房1330或1335处以更少的填写错误执行处方填写。导电地获得的信息可以被用于从健康护理医师1350以及药剂师(管理药方)和制造厂1310(为了市场情报，例如销售预测等)所服务(employ)的患者1340获得剂量信息。对导电地获得的IEM信息的使用被进一步描述在PCT公开的公开号为WO 2006/116718；WO2008/008281；WO2008/095183和WO2008/063626的申请中；在此将其这些申请的公开以引用的形式并入。
需要理解的是，本发明不限于所描述的具体实施方式，因为这可以变化。还需要理解的是，在此使用的术语只是为了描述具体实施方式的目的，并非旨在限制，因为本发明的范围将只由所附的权利要求限定。
在提供数值范围的地方，应理解到，每一个在该范围的上限和下限之间、除非文中明确的指出否则到下限单位的十分之一的中间值，以及任何其它陈述的或在该所陈述的范围内的中间值，都被包含在本发明中。这些较小范围的上限和下限可以被独立地包括在较小的范围中并且也被包括在本发明中，服从于在所陈述的范围内任何被特别地排除的限值。在所陈述的范围包括限值中的一个或两个的地方，排除了那些被包括的限值中的任一个或两个的范围同样被包括在本发明中。
除非另外定义，所有在此使用的技术和科学术语，具有与本发明所属的技术领域中普通技术人员所一般理解的同样的含义。尽管类似于或等同于在此描述的那些任何方法和材料，也可以被用于本发明的实施或测试中，现在描述代表性的示意性的方法和材料。
在本说明书中引用的所有公开和专利如同每一个独立的公开或专利被特别并单独地指示通过引用的方式并入一样，在此以参考的形式并入，并且在此以引用的方式被并入从而公开及描述与该所引用的公开相关的方法和/或材料。对任何公开的引用都是因为在申请日之前的它的公开，并且不能被解释为承认本发明由于之前的发明而没有资格早于这种公开。此外，所提供公开日可以与实际公开日期不同，这需要单独确认。
注意到，如在此和在所附的权利要求中所使用的一样，单数形式“一个”“该”及“所述”包括复数参考，除非上下文另外明确指出。进一步注意到，权利要求可以被撰写为排除任何可选的元件。因此，这种描述旨在用作使用这种像“惟一的”、“只”等与所主张的元件的陈述有关的排它性术语，或者使用“否定”限制的在先基础。
某些范围在此已经用在前面加了术语“大约”的数值所描述。术语“大约”在此用于提供对其引导的确切数字的字面支持，以及接近或近似该术语引导的数字的数字。在确定数字是否接近或近似所特别列举的数字时，未被列举的接近或近似的数字可能是在其出现的上下文中，提供所特别列举的数字的大体等效的数字。
如在阅读本公开时对本领域技术人员而言将显而易见的那样，在此描述和说明性示意的每一个单独的实施方式具有分立的部件和特征，在不脱离本发明的精神和范围的情况下，这些部件和特征易于与任何其它若干实施方式的多个特征中分离或组合。任何所列举的方法可以按照所列举的事件的顺序或以任何其它逻辑上可能的顺序来执行。
尽管为了理解的清楚性，前述发明已经通过示意和举例的方式进行了详细的描述，但按照本发明的讨论，对本领域的技术人员而言显而易见的是，在不脱离所附的专利要求的精神或范围的情况下，可以另外进行某些变化和修改。
相应的，上文只说明了本发明的原理。将被理解的是，本领域的技术员将能够设计出实现本发明的原理并被包括在其精神和范围内的不同的布置，尽管在此没有明确的描述或示出。此外，在此列举的所有例子和条件性语言主要旨在帮助读者理解本发明的原理以及发明人所提供的深化本技术的概念，并且将被解释为无需受到这样特别地所陈述的例子和条件的限制。并且，在此所列举本发明的原理、各方面和各实施方式及其特定例子的所有陈述，旨在包含其结构的和功能的等同物。另外，这种等同物包括当前已知的等同物和未来开发的等同物，即所开发的执行相同功能的任何元件，而不管结构。因此，本发明的范围并非限制在此所给出及描述的示范性实施方式。相反，本发明的范围和精神由所附的专利要求来体现。

Claims (23)

1.一种系统，其包括：
包括集成电路的可摄取的部件，所述集成电路包括被配置以发出第一信号的导电通信模块；
第二非导电通信模块，被配置以发出第二信号；以及
接收器，其中所述接收器、导电通信模块和非导电通信模块被配置以在导电通信模块与非导电通信模块中的至少一个和接收器之间，提供信息的传输；
其中所述接收器被配置以接收所述第一信号和所述第二信号中的至少一个；
其中所述接收器被配置以接收所述第二信号；
其中所述接收器是制造系统的部件。
2.根据权利要求1所述的系统，其中所述接收器包括射频阅读器。
3.根据权利要求1所述的系统，其中所述接收器被配置以向所述非导电通信模块传送信息。
4.根据权利要求1所述的系统，其中所述接收器与分类器相关联。
5.根据权利要求1所述的系统，其中所述接收器与编码器相关联。
6.根据权利要求1所述的系统，其中所述第一信号包括非生理学数据。
7.根据权利要求6所述的系统，其中所述接收器被配置为可移除地附接到生物。
8.根据权利要求7所述的系统，其中所述接收器包括粘合部件。
9.根据权利要求1所述的系统，其中所述接收器是可植入接收器。
10.根据权利要求1所述的系统，其中所述接收器被配置为电激发设备。
11.一种设备，其包括：
包括集成电路的可摄取的部件，所述集成电路包括导电通信模块；和
第二非导电通信模块；
其中可摄取的部件包括电源；以及
其中所述电源包括由不同材料制作的电极对。
12.根据权利要求11所述的设备，其中所述第二非导电通信模块包括从由无线射频模块、磁感应模块、光学模块、听觉模块、和有线模块构成的组中选择的至少一个模块。
13.根据权利要求12所述的设备，其中所述无线射频模块包括射频识别模块。
14.根据权利要求11所述的设备，其中所述设备包括电性耦合到所述非导电通信模块的第二电源。
15.一种系统，其包括：
包括集成电路的可摄取的部件，所述集成电路包括被配置以发出第一信号的导电通信模块；
第二非导电通信模块，被配置以发出第二信号；以及
接收器，其中所述接收器、导电通信模块和非导电通信模块被配置以在导电通信模块与非导电通信模块中的至少一个和接收器之间，提供信息的传输；
其中所述接收器被配置以接收所述第一信号和所述第二信号中的至少一个；以及
其中所述接收器是供应链管理系统的部件。
16.根据权利要求15所述的系统，其中所述接收器包括射频阅读器。
17.根据权利要求15所述的系统，其中所述接收器被配置以向非导电通信模块传送信息。
18.根据权利要求17所述的系统，其中所述第一信号包括非生理学数据。
19.根据权利要求18所述的系统，其中所述接收器被配置为可移除地附接到生物。
20.根据权利要求19所述的系统，其中所述接收器包括粘合部件。
21.根据权利要求17所述的系统，其中所述接收器是可植入接收器。
22.一种系统，其包括：
包括集成电路的可摄取的部件，所述集成电路包括被配置以发出第一信号的导电通信模块；
第二非导电通信模块，被配置以发出第二信号；以及
接收器，其中所述接收器、导电通信模块和非导电通信模块被配置以在导电通信模块与非导电通信模块中的至少一个和接收器之间，提供信息的传输；
其中所述接收器被配置以接收所述第一信号和所述第二信号中的至少一个；
其中所述第一信号包括非生理学数据；以及
其中所述接收器被配置为可移除地附接到生物。
23.一种系统，其包括：
包括集成电路的可摄取的部件，所述集成电路包括被配置以发出第一信号的导电通信模块；
第二非导电通信模块，被配置以发出第二信号；以及
接收器，其中所述接收器、导电通信模块和非导电通信模块被配置以在导电通信模块与非导电通信模块中的至少一个和接收器之间，提供信息的传输；
其中所述接收器被配置以接收所述第一信号和所述第二信号中的至少一个；以及
其中所述接收器是可植入接收器。
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