CN104399129A - Material for preparing artificial joints and preparation method thereof - Google Patents

Material for preparing artificial joints and preparation method thereof Download PDF

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Publication number
CN104399129A
CN104399129A CN201410626137.8A CN201410626137A CN104399129A CN 104399129 A CN104399129 A CN 104399129A CN 201410626137 A CN201410626137 A CN 201410626137A CN 104399129 A CN104399129 A CN 104399129A
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Prior art keywords
parts
artificial joint
joint material
silicone rubber
calcium hydroxide
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CN201410626137.8A
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CN104399129B (en
Inventor
潘林根
邱东成
刘乐峰
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SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
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SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
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Priority to CN201610269088.6A priority Critical patent/CN105833352B/en
Priority to CN201610262347.2A priority patent/CN105854086B/en
Priority to CN201610259463.9A priority patent/CN105802232B/en
Priority to CN201610259319.5A priority patent/CN105833351B/en
Priority to CN201610259376.3A priority patent/CN105833347B/en
Application filed by SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd filed Critical SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
Priority to CN201610259318.0A priority patent/CN105749344B/en
Priority to CN201410626137.8A priority patent/CN104399129B/en
Publication of CN104399129A publication Critical patent/CN104399129A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/08—Carbon ; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a material for preparing artificial joints and a preparation method thereof. The material is composed of the following raw materials in parts by weight: 40 to 60 parts of silicone rubber, 10 to 20 parts of collagen, 1.5 to 4 parts of vinyl silicone oil, 20 to 32 parts of fume silica, and 0.8 to 3 parts of calcium hydroxide. The provided material has the advantages of excellent bioactivity, biocompatibility, and bone conductive performance. The performances of the material are better than those of the medical titanium and silicone rubber. The material also has the advantages of high strength and good mechanical properties.

Description

One prepares artificial joint material and preparation method thereof
Technical field
The present invention relates to medical applications field, particularly relate to one and prepare artificial joint material and preparation method thereof.
Background technology
Artificial joint is people for saving the joint having lost function and a kind of artificial organ designed, and it belongs to the best one of curative effect in artificial organ.In general, its service life can reach more than 20 years.Along with scientific and technological progress; artificial joint operation has been the very successful and safe operation of one: it can eliminate the normal activity function in arthralgia, recovery joint at once; the people tormented by joint slight illness are for a long time made again to obtain new life; Post operation can be walked, climb building, travel outdoors as normal person, work of going out, shopping and physical training etc.
The metal parts of artificial joint once adopted rustless steel to manufacture, and had developed again cobalt-alloy material afterwards, and the corrosion resistance of cobalt alloy, wearability and mechanical performance are all better.Recently developed again titanium or titanium alloy material, titanium-containing materials is not only corrosion-resistant, and proportion is little, and easier and that people is autologous bone grows together, and is desirable material.Generally high density Polyethylene with Ultra High Molecular Weight is all lined with between artificial joint metal parts.
People just adopt various artificial joint to treat ankylosis, joint deformity and various destructive joint disease for many years, try hard to these ill joint correction, and restore funcitons, make it to become stable, do not ache, and have the joint of certain function.Many scholars have made huge effort for this reason.Developed knee joint, hip, elbow so far, takeed on, referred to, toe joint prosthese, for clinical.
Prosthetic replacement's operation of annual 200000 examples of China.Over nearly 20 years, the number of the infected of China's joint disease constantly rises, and wherein Senior osteoarthritis is maximum a kind of joint disease of falling ill.In current China more than 60 years old old man, have the people of 55% to suffer from osteoarthritis, the whole nation about has 1.2 hundred million people to suffer from this disease.Joint replacement quantity increases with the speed more than 30% every year.China have the number of osteoarthritis account for total population 3%, rheumatoid patient accounts for 0.3%, tetanic patient accounts for 0.3%, establishes a capital will perform an operation although this several ten million people differs, needing the number of performing an operation minimum is more than 10 times that implement operation number.Namely need the number making artificial joint more than 2,000,000, calculate by every routine artificial joint material expense 4-6 ten thousand, market desirability more than 80,000,000,000, but needs to perform an operation and the ratio implementing operation accounts for 10%-20% greatly at present.Namely existing market scale is approximately 80 hundred million to 160 hundred million, and along with life raising and medical reform are goed deep into, medical condition is improved, and the artificial joint replacement surgery speedup of current China is 30%.
Existingly in the market prepare that the brittleness of artificial joint material own is high, rupture strength is low, and not there is good biological activity and biocompatibility.
Summary of the invention
the technical problem solved:for the existing shortcoming prepared artificial joint material and exist, the invention provides one and prepare artificial joint material and preparation method thereof, this material has excellent biological activity, biocompatibility and bone conductibility, and its intensity is high, good mechanical property.
technical scheme:one prepares artificial joint material, comprises the following raw material according to mass fraction meter: 40 ~ 60 parts, silicone rubber, collagen protein 10 ~ 20 parts, vinyl silicone oil 1.5 ~ 4 parts, Meteorological Act white carbon 20 ~ 32 parts, calcium hydroxide 0.8 ~ 3 part.
One described above prepares artificial joint material, comprises the following raw material according to mass fraction meter: 45 ~ 55 parts, silicone rubber, collagen protein 12 ~ 18 parts, vinyl silicone oil 2 ~ 3 parts, Meteorological Act white carbon 24 ~ 30 parts, calcium hydroxide 1.3 ~ 2.3 parts.
One described above prepares artificial joint material, comprises the following raw material according to mass fraction meter: 48 parts, silicone rubber, collagen protein 14 parts, vinyl silicone oil 2.2 parts, Meteorological Act white carbon 25 parts, calcium hydroxide 1.5 parts.
One described above prepares artificial joint material, comprises the following raw material according to mass fraction meter: 50 parts, silicone rubber, collagen protein 15 parts, vinyl silicone oil 2.5 parts, Meteorological Act white carbon 27 parts, calcium hydroxide 1.8 parts.
A kind of preparation method preparing artificial joint material described above, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 10 ~ 20min in extruder, extrude at temperature is 180 ~ 200 DEG C, artificial joint material must be prepared.
Melt blending 15min described above, extrudes at temperature is 190 DEG C.
beneficial effect:compared with prior art, one provided by the invention prepares artificial joint material and preparation method thereof, and this material has excellent biological activity, biocompatibility and bone conductibility, be all better than medical titanium and silicone rubber, and its intensity is high, good mechanical property.
Detailed description of the invention
embodiment 1
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 40 parts, silicone rubber, collagen protein 10 parts, vinyl silicone oil 1.5 parts, Meteorological Act white carbon 20 parts, calcium hydroxide 0.8 part.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 10min in extruder, extrude at temperature is 180 DEG C, artificial joint material must be prepared.
embodiment 2
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 60 parts, silicone rubber, collagen protein 20 parts, vinyl silicone oil 4 parts, Meteorological Act white carbon 32 parts, calcium hydroxide 3 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 20min in extruder, extrude at temperature is 200 DEG C, artificial joint material must be prepared.
embodiment 3
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 45 parts, silicone rubber, collagen protein 12 parts, vinyl silicone oil 2 parts, Meteorological Act white carbon 24 parts, calcium hydroxide 1.3 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 10min in extruder, extrude at temperature is 180 DEG C, artificial joint material must be prepared.
embodiment 4
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 55 parts, silicone rubber, collagen protein 18 parts, vinyl silicone oil 3 parts, Meteorological Act white carbon 30 parts, calcium hydroxide 2.3 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 20min in extruder, extrude at temperature is 200 DEG C, artificial joint material must be prepared.
embodiment 5
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 52 parts, silicone rubber, collagen protein 17 parts, vinyl silicone oil 2.8 parts, Meteorological Act white carbon 28 parts, calcium hydroxide 2 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 20min in extruder, extrude at temperature is 200 DEG C, artificial joint material must be prepared.
embodiment 6
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 48 parts, silicone rubber, collagen protein 14 parts, vinyl silicone oil 2.2 parts, Meteorological Act white carbon 25 parts, calcium hydroxide 1.5 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 15min in extruder, extrude at temperature is 190 DEG C, artificial joint material must be prepared.
embodiment 7
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 50 parts, silicone rubber, collagen protein 15 parts, vinyl silicone oil 2.5 parts, Meteorological Act white carbon 27 parts, calcium hydroxide 1.8 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 15min in extruder, extrude at temperature is 190 DEG C, artificial joint material must be prepared.
performance test
Test the performance of the embodiment of the present invention 1 ~ 7 product, test result is in table 1.
Table 1 properties of product test data
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Embodiment 6 Embodiment 7
Bending strength/MPa 176 173 178 182 183 186 190
Hot strength/MPa 51 54 56 55 57 58 60
Above to invention has been detailed introduction, for one of ordinary skill in the art, according to the thought of the embodiment of the present invention, all will change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.

Claims (6)

1. prepare an artificial joint material, it is characterized in that comprising the following raw material according to mass fraction meter: 40 ~ 60 parts, silicone rubber, collagen protein 10 ~ 20 parts, vinyl silicone oil 1.5 ~ 4 parts, Meteorological Act white carbon 20 ~ 32 parts, calcium hydroxide 0.8 ~ 3 part.
2. one according to claim 1 prepares artificial joint material, it is characterized in that comprising the following raw material according to mass fraction meter: 45 ~ 55 parts, silicone rubber, collagen protein 12 ~ 18 parts, vinyl silicone oil 2 ~ 3 parts, Meteorological Act white carbon 24 ~ 30 parts, calcium hydroxide 1.3 ~ 2.3 parts.
3. one according to claim 1 prepares artificial joint material, it is characterized in that comprising the following raw material according to mass fraction meter: 48 parts, silicone rubber, collagen protein 14 parts, vinyl silicone oil 2.2 parts, Meteorological Act white carbon 25 parts, calcium hydroxide 1.5 parts.
4. one according to claim 1 prepares artificial joint material, it is characterized in that comprising the following raw material according to mass fraction meter: 50 parts, silicone rubber, collagen protein 15 parts, vinyl silicone oil 2.5 parts, Meteorological Act white carbon 27 parts, calcium hydroxide 1.8 parts.
5. a kind of preparation method preparing artificial joint material as claimed in claim 1, it is characterized in that comprising the steps: silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide to add melt blending 10 ~ 20min in extruder, extrude at temperature is 180 ~ 200 DEG C, artificial joint material must be prepared.
6. a kind of preparation method preparing artificial joint material according to claim 5, is characterized in that: described melt blending 15min, extrudes at temperature is 190 DEG C.
CN201410626137.8A 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof Active CN104399129B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201610262347.2A CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610259463.9A CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof
CN201610259319.5A CN105833351B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio is active
CN201610259376.3A CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610269088.6A CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201610259318.0A CN105749344B (en) 2014-11-10 2014-11-10 Material with excellent biological activity for preparing artificial joint
CN201410626137.8A CN104399129B (en) 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410626137.8A CN104399129B (en) 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof

Related Child Applications (6)

Application Number Title Priority Date Filing Date
CN201610262347.2A Division CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610259318.0A Division CN105749344B (en) 2014-11-10 2014-11-10 Material with excellent biological activity for preparing artificial joint
CN201610259376.3A Division CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610269088.6A Division CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201610259319.5A Division CN105833351B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio is active
CN201610259463.9A Division CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof

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CN104399129A true CN104399129A (en) 2015-03-11
CN104399129B CN104399129B (en) 2016-08-24

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CN201610259319.5A Expired - Fee Related CN105833351B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio is active
CN201410626137.8A Active CN104399129B (en) 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof
CN201610269088.6A Active CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201610259376.3A Active CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610262347.2A Active CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610259463.9A Expired - Fee Related CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof

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CN201610269088.6A Active CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201610259376.3A Active CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610262347.2A Active CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610259463.9A Expired - Fee Related CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof

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CN102580583A (en) * 2012-03-30 2012-07-18 中蓝晨光化工研究设计院有限公司 Preparation method for silicon rubber ultrathin pemeable membranes

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CN105802232B (en) 2018-06-15
CN105833351A (en) 2016-08-10
CN105833347B (en) 2019-06-04
CN105833352B (en) 2019-03-08
CN105833352A (en) 2016-08-10
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