CN104399129B - One prepares joint prosthesis material and preparation method thereof - Google Patents

One prepares joint prosthesis material and preparation method thereof Download PDF

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Publication number
CN104399129B
CN104399129B CN201410626137.8A CN201410626137A CN104399129B CN 104399129 B CN104399129 B CN 104399129B CN 201410626137 A CN201410626137 A CN 201410626137A CN 104399129 B CN104399129 B CN 104399129B
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China
Prior art keywords
parts
joint prosthesis
silicon rubber
prosthesis material
collagen
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CN201410626137.8A
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Chinese (zh)
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CN104399129A (en
Inventor
涂敏
梁军
周峰
王开秀
李玲玲
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Jingmen Second Peoples Hospital
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Jingmen Second Peoples Hospital
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Publication date
Priority to CN201610259463.9A priority Critical patent/CN105802232B/en
Priority to CN201610259376.3A priority patent/CN105833347B/en
Priority to CN201610269088.6A priority patent/CN105833352B/en
Priority to CN201610259319.5A priority patent/CN105833351B/en
Priority to CN201610262347.2A priority patent/CN105854086B/en
Application filed by Jingmen Second Peoples Hospital filed Critical Jingmen Second Peoples Hospital
Priority to CN201610259318.0A priority patent/CN105749344B/en
Priority to CN201410626137.8A priority patent/CN104399129B/en
Publication of CN104399129A publication Critical patent/CN104399129A/en
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Publication of CN104399129B publication Critical patent/CN104399129B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/08—Carbon ; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend

Abstract

The present invention provides one to prepare joint prosthesis material and preparation method thereof, this material includes the following raw material according to mass fraction meter: silicon rubber 40～60 parts, collagen 10～20 parts, vinyl silicone oil 1.5～4 parts, Meteorological Act white carbon 20～32 parts, calcium hydroxide 0.8～3 parts.The material that the present invention provides has biologically active, biocompatibility and the osteoconductive of excellence, is superior to medical titanium and silicon rubber, and its intensity is high, good mechanical property.

Description

One prepares joint prosthesis material and preparation method thereof
Technical field
The present invention relates to medical applications field, particularly relate to one and prepare joint prosthesis material and preparation method thereof.
Background technology
Joint prosthesis is people for saving the joint having lost function and a kind of artificial organs designed, and it belongs to the one that curative effect is best in artificial organs.In general, its service life was up to more than 20 years.Along with scientific and technological progress; joint prosthesis operation has been the most successful and safe operation of one: it can at once eliminate arthralgia, recover the normal activity function in joint; the people tormented by joint slight illness for a long time are made again to obtain new life; Post operation can walk as normal person, climb building, travel outdoors, work of going out, shopping and physical training etc..
The metal parts of joint prosthesis once used stainless steel to manufacture, and had developed the most again cobalt-alloy material, and the corrosion resistance of cobalt alloy, wearability and mechanical performance are preferable.Recently having developed again titanium or titanium alloy material, titanium-containing materials is the most corrosion-resistant, and proportion is little, is more easy to the bone autologous with people and grows together, and is preferable material.Typically high density Polyethylene with Ultra High Molecular Weight all it is lined with between joint prosthesis metal parts.
People just use various joint prosthesis treatment arthrocleisis, joint deformity and various destructive bone and joint diseases for many years, try hard to these ill joint correction, and recover function, make stable, do not ache, and have the joint of certain function.It is made that huge effort for these many scholars.Have been developed that so far knee, hip, elbow, take on, refer to, toe joint prosthese, for clinic.
Prosthetic replacement's operation of annual 200000 examples of China.Over nearly 20 years, the number of the infected of China's joint disease constantly rises, and wherein Senior osteoarthritis is a kind of joint disease that morbidity is most.At present in more than 60 years old old man of China, having the people of 55% to suffer from osteoarthritis, the whole nation there are about 1.2 hundred million people and suffers from this disease.Joint replacement quantity increases with the speed more than 30% every year.China has the number of Osteoarthritis to account for the 3% of total population, rheumatoid patient accounts for 0.3%, tetanic patient accounts for 0.3%, although these several million people not necessarily will be performed an operation, but needs minimum be to implement operation number more than 10 times of the number performed an operation.Namely needing the number making joint prosthesis more than 2,000,000, calculate by every example artificial joint material expense 4-6 ten thousand, market desirability is more than 80,000,000,000, but the ratio performing an operation and implement perform the operation is presently required and constitutes about 10%-20%.Namely existing market scale is about 80 hundred million to 160 hundred million, improves along with life and medical reform is goed deep into, and medical condition is improved, and current China artificial joint replacement surgery speedup is 30%.
The most existing prepare that the brittleness of joint prosthesis material own is high, rupture strength is low, and not there is good biologically active and biocompatibility.
Summary of the invention
Solve the technical problem that:Preparing, for existing, the shortcoming that joint prosthesis material exists, the present invention provides one to prepare joint prosthesis material and preparation method thereof, and this material has biologically active, biocompatibility and the osteoconductive of excellence, and its intensity is high, good mechanical property.
Technical scheme:One prepares joint prosthesis material, the following raw material including according to mass fraction meter: silicon rubber 40～60 parts, collagen 10～20 parts, vinyl silicone oil 1.5～4 parts, fume colloidal silica 20～32 parts, calcium hydroxide 0.8～3 parts.
One described above prepares joint prosthesis material, the following raw material including according to mass fraction meter: silicon rubber 45～55 parts, collagen 12～18 parts, vinyl silicone oil 2～3 parts, fume colloidal silica 24～30 parts, calcium hydroxide 1.3～2.3 parts.
One described above prepares joint prosthesis material, the following raw material including according to mass fraction meter: 48 parts of silicon rubber, collagen 14 parts, vinyl silicone oil 2.2 parts, fume colloidal silica 25 parts, 1.5 parts of calcium hydroxide.
One described above prepares joint prosthesis material, the following raw material including according to mass fraction meter: 50 parts of silicon rubber, collagen 15 parts, vinyl silicone oil 2.5 parts, fume colloidal silica 27 parts, 1.8 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material described above, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 10～20min in extruder, extrude at temperature is 180～200 DEG C, joint prosthesis material must be prepared.
Melt blending 15min described above, extrudes at temperature is 190 DEG C.
Beneficial effect:Compared with prior art, the one that the present invention provides prepares joint prosthesis material and preparation method thereof, and this material has biologically active, biocompatibility and the osteoconductive of excellence, is superior to medical titanium and silicon rubber, and its intensity is high, good mechanical property.
Detailed description of the invention
Embodiment 1
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 40 parts of silicon rubber, collagen 10 parts, vinyl silicone oil 1.5 parts, fume colloidal silica 20 parts, 0.8 part of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 10min in extruder, extrude at temperature is 180 DEG C, joint prosthesis material must be prepared.
Embodiment 2
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 60 parts of silicon rubber, collagen 20 parts, vinyl silicone oil 4 parts, fume colloidal silica 32 parts, 3 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 20min in extruder, extrude at temperature is 200 DEG C, joint prosthesis material must be prepared.
Embodiment 3
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 45 parts of silicon rubber, collagen 12 parts, vinyl silicone oil 2 parts, fume colloidal silica 24 parts, 1.3 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 10min in extruder, extrude at temperature is 180 DEG C, joint prosthesis material must be prepared.
Embodiment 4
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 55 parts of silicon rubber, collagen 18 parts, vinyl silicone oil 3 parts, fume colloidal silica 30 parts, 2.3 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 20min in extruder, extrude at temperature is 200 DEG C, joint prosthesis material must be prepared.
Embodiment 5
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 52 parts of silicon rubber, collagen 17 parts, vinyl silicone oil 2.8 parts, fume colloidal silica 28 parts, 2 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 20min in extruder, extrude at temperature is 200 DEG C, joint prosthesis material must be prepared.
Embodiment 6
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 48 parts of silicon rubber, collagen 14 parts, vinyl silicone oil 2.2 parts, fume colloidal silica 25 parts, 1.5 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 15min in extruder, extrude at temperature is 190 DEG C, joint prosthesis material must be prepared.
Embodiment 7
One prepares joint prosthesis material, the following raw material including according to mass fraction meter: 50 parts of silicon rubber, collagen 15 parts, vinyl silicone oil 2.5 parts, fume colloidal silica 27 parts, 1.8 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, comprise the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 15min in extruder, extrude at temperature is 190 DEG C, joint prosthesis material must be prepared.
Performance test
Testing the performance of the embodiment of the present invention 1 ~ 7 product, test result is shown in Table 1.
Table 1 properties of product test data
Above the present invention is described in detail, for one of ordinary skill in the art, according to the thought of the embodiment of the present invention, the most all will change, in sum, this specification content should not be construed as limitation of the present invention.

Claims (6)

1. prepare joint prosthesis material for one kind, it is characterised in that include the following raw material according to mass fraction meter: silicon rubber 40～60 parts, collagen 10～20 parts, vinyl silicone oil 1.5～4 parts, fume colloidal silica 20～32 parts, calcium hydroxide 0.8～3 parts.
One the most according to claim 1 prepares joint prosthesis material, it is characterized in that including the following raw material according to mass fraction meter: silicon rubber 45～55 parts, collagen 12～18 parts, vinyl silicone oil 2～3 parts, fume colloidal silica 24～30 parts, calcium hydroxide 1.3～2.3 parts.
One the most according to claim 1 prepares joint prosthesis material, it is characterised in that include the following raw material according to mass fraction meter: 48 parts of silicon rubber, collagen 14 parts, vinyl silicone oil 2.2 parts, fume colloidal silica 25 parts, 1.5 parts of calcium hydroxide.
One the most according to claim 1 prepares joint prosthesis material, it is characterised in that include the following raw material according to mass fraction meter: 50 parts of silicon rubber, collagen 15 parts, vinyl silicone oil 2.5 parts, fume colloidal silica 27 parts, 1.8 parts of calcium hydroxide.
A kind of preparation method preparing joint prosthesis material, it is characterized in that comprising the steps: silicon rubber, collagen, vinyl silicone oil, fume colloidal silica and calcium hydroxide are added melt blending 10～20min in extruder, extrude at temperature is 180～200 DEG C, joint prosthesis material must be prepared.
A kind of preparation method preparing joint prosthesis material the most according to claim 5, it is characterised in that: described melt blending 15min, extrudes at temperature is 190 DEG C.
CN201410626137.8A 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof Active CN104399129B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201610259376.3A CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610269088.6A CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201610259319.5A CN105833351B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio is active
CN201610262347.2A CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610259463.9A CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof
CN201610259318.0A CN105749344B (en) 2014-11-10 2014-11-10 Material with excellent biological activity for preparing artificial joint
CN201410626137.8A CN104399129B (en) 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410626137.8A CN104399129B (en) 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof

Related Child Applications (6)

Application Number Title Priority Date Filing Date
CN201610262347.2A Division CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610259319.5A Division CN105833351B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio is active
CN201610259318.0A Division CN105749344B (en) 2014-11-10 2014-11-10 Material with excellent biological activity for preparing artificial joint
CN201610269088.6A Division CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201610259376.3A Division CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610259463.9A Division CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof

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CN104399129A CN104399129A (en) 2015-03-11
CN104399129B true CN104399129B (en) 2016-08-24

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CN201610259463.9A Expired - Fee Related CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof
CN201610259376.3A Active CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610262347.2A Active CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610269088.6A Active CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility
CN201410626137.8A Active CN104399129B (en) 2014-11-10 2014-11-10 One prepares joint prosthesis material and preparation method thereof
CN201610259319.5A Expired - Fee Related CN105833351B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio is active

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CN201610259463.9A Expired - Fee Related CN105802232B (en) 2014-11-10 2014-11-10 It is a kind of to prepare joint prosthesis material and preparation method thereof
CN201610259376.3A Active CN105833347B (en) 2014-11-10 2014-11-10 Joint prosthesis material and preparation method thereof is prepared with superior bio compatibility
CN201610262347.2A Active CN105854086B (en) 2014-11-10 2014-11-10 With the active preparation method for preparing joint prosthesis material of superior bio
CN201610269088.6A Active CN105833352B (en) 2014-11-10 2014-11-10 Joint prosthesis material is prepared with superior bio compatibility

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CN107868303A (en) * 2017-11-21 2018-04-03 安徽北马科技有限公司 A kind of preparation method of modified collagen albumen rubber composite

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CN102363050A (en) * 2011-06-29 2012-02-29 大连林桥科技有限公司 Medical biological material and preparation method thereof
CN102580583A (en) * 2012-03-30 2012-07-18 中蓝晨光化工研究设计院有限公司 Preparation method for silicon rubber ultrathin pemeable membranes

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CN105802232B (en) 2018-06-15
CN105802232A (en) 2016-07-27
CN105833347A (en) 2016-08-10
CN105833352B (en) 2019-03-08
CN105854086B (en) 2019-06-04
CN105833351B (en) 2019-03-22
CN104399129A (en) 2015-03-11
CN105833352A (en) 2016-08-10
CN105833351A (en) 2016-08-10
CN105854086A (en) 2016-08-17
CN105833347B (en) 2019-06-04

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