CN104414826B - Brain injury in rats sensation-balance-motion integrated training devices - Google Patents

Brain injury in rats sensation-balance-motion integrated training devices Download PDF

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Publication number
CN104414826B
CN104414826B CN201310413625.6A CN201310413625A CN104414826B CN 104414826 B CN104414826 B CN 104414826B CN 201310413625 A CN201310413625 A CN 201310413625A CN 104414826 B CN104414826 B CN 104414826B
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China
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training
balance
cage
treadmill
outer gimbal
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CN201310413625.6A
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Chinese (zh)
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CN104414826A (en
Inventor
胡秀枋
徐秀林
安美君
赵展
马关坡
徐奚娇
赵俊
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University of Shanghai for Science and Technology
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University of Shanghai for Science and Technology
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Abstract

A kind of brain injury in rats sensation balance exercise integrated training device, including outer gimbal support, control station and multiple training cage, control station is connected to the outside of outer gimbal support, multiple training cages are mounted side by side in outer gimbal support, multiple training cages include that at least one anterior-posterior balance training cage and at least one left-right balance train cage, are respectively equipped with treadmill in each training cage;It is provided with swing governor motion in the lower section of anterior-posterior balance training cage, is provided with, in the lower section of left-right balance training cage, the governor motion that swings.Control station telecom-connects with each treadmill, swing governor motion, the governor motion that swings.Assembly of the invention both can carry out single treadmill training, can implement again to feel the Multifunctional rehabilitation exercise pattern of balance one motion, meet the experiment demand of researcher, for the zoopery means that the neuromechanism rehabilitation research offer of brain injury disease is advanced.

Description

Brain injury in rats sensation-balance-motion integrated training devices
Technical field
The present invention relates to a kind of medical simulation experimental provision, particularly to a kind of brain injury in rats sensation-balance-motion Integrated training device.
Background technology
Brain injury includes apoplexy, is common clinical disease, and sickness rate is high, mortality rate is high, disability rate is high and controls More rate is low, and its high disability rate causes great burden to patient, family and society.Clinical experiment confirms, feels one Balance the rehabilitation therapies such as a motion and can improve brain injury sequela patient's locomotor activity, but its neuromechanism is the most not clear Really, this hinders the development of rehabilitation medicine to a certain extent.Human experimentation is limited by methodology and morals aspect System, is had bigger limitation, is highly desirable to be studied by zoopery.The gene phase of rat and the mankind Seemingly, use rat to be simulated the experiment of physiological pathology of human body state, study various intervention or the one-tenth of rehabilitation means Effect and mechanism, essence and rehabilitation to understanding disease have extremely important effect, are to promote clinic to break through Important means.
Domestic and international existing many runways laboratory animal treadmill, U.S.'s Exer-3/6 animal testing running platform etc., but its function list One, motor function training can only be carried out, and post-stroke early stage i.e. carries out Aerobic Exercise Training and is not inconsistent clinical status. In clinical rehabilitation treatment, apoplexy early stage patient cannot complete active exercise, and therapist gives outside passive manipulation, The most often allow limbs of patient friction, touch, experience different feel and the material of quality, train it to distinguish object ability, To promote that its sensory function is recovered.Treat that patient's muscular strength and sensory function have been recovered, after independently standing, due to it Muscular strength still can not meet motion needs, therefore first gives balance function training, including balance plate training etc..At patient's flesh After power is recovered further, patient is just allowed to carry out active exercise training.Rehabilitation of stroke patients is treated, modern rehabilitation Theory, not only for the improvement of motor function, also needs the improvement including sense of touch with static sense.Impercipience is fed back, and suffers from Person is difficult to normally regulation and controls motion, maintain posture and keep balance.Feel in the training process, balance and transport Dynamic training can not be well-separated, it is necessary to sets up the concept of sensation one balance one training integration.
Therefore, research and develop a kind of novel multi-functional rat device for healing and training meeting modern rehabilitation medicine theory, use Significant in the training such as rat or the sense culture of other animals, balance function training, motor function.Multi-functional Rat device for healing and training both can carry out single treadmill training, can implement again to feel balance one exercise rehabilitation training Method combines, and simulates the multifunction rehabilitation training pattern of sensation one balance one motion clinically truly, moreover it is possible to Select velocity, sway velocity, training time etc. according to requirement of experiment flexibly, quantify training burden, meet research The experiment demand of person, the neuromechanism rehabilitation balancing a motion and combinations thereof therapy for the sensation one of brain injury disease is ground Study carefully the zoopery means providing advanced.
Summary of the invention
The purpose of the present invention, in that solve the problems referred to above, it is provided that a kind of brain injury in rats sensation-balance-motion one Body training devices.
The object of the present invention is achieved like this: a kind of brain injury in rats sensation-balance-motion integrated training cartridge Putting, including outer gimbal support, control station and multiple training cage, control station is connected to the outside of outer gimbal support, Duo Gexun Practice cage be mounted side by side in outer gimbal support, multiple training cages include at least one anterior-posterior balance training cage and at least one Left-right balance training cage, is respectively equipped with treadmill: before and after the lower section of anterior-posterior balance training cage is provided with in each training cage Swing regulation mechanism can drive described treadmill swing;It is provided with in the lower section of left-right balance training cage and swings Governor motion can drive described treadmill to swing;Described control station and each treadmill, swing governor motion, The governor motion that swings telecom-connects and controls its kinestate.
Described each training cage includes base and case respectively;The base of described anterior-posterior balance training cage and outer gimbal support Base plate is rotatably connected, and described swing governor motion is arranged on the base plate of outer gimbal support and instructs with anterior-posterior balance The base drive of white silk cage is connected and can drive base swing: the base of described left-right balance training cage and outer gimbal support Two end plates be rotatably connected, described in swing governor motion be arranged on the base plate of outer gimbal support and with left and right put down The base drive of weighing apparatus training cage is connected and base can be driven to swing;The case of described anterior-posterior balance training cage is with corresponding Base is fixedly linked, and the case of described left-right balance training cage is fixedly linked with outer gimbal support by support bar;Described Treadmill is separately mounted on the base of each training cage.
Described case is formed by enclosing transparent with machine glass, and has smooth inner surface, sets above case Air-vent, case is had to be respectively arranged at two ends with removable top cover.
Described treadmill is by the crawler type treadmill of driven by motor.
With sticking double faced adhesive tape, there is the fur of different coefficients of friction, canvas, yarn on the crawler belt of described crawler type treadmill Cloth or bristle.
The case of described anterior-posterior balance training cage is square case, and respective activity top cover is flat cover;Described left-right balance The case of training cage is circular arc case, and respective activity top cover is circular arc lid: the end of described left-right balance training cage Seat both sides are connected to circular arc side plate, in two circular arc side plates are sleeved on described circular arc case and can be along circle Arc cap swings.
The afterbody of each training cage is respectively equipped with electricity irritation mechanism, and this electricity irritation mechanism includes back plate and multiple electricity irritation Bar, back plate is arranged on the tail end of training cage, and multiple electricity irritation bar equidistant arrangement are inclined and mounted in back plate, electricity irritation Bar is horizontal U-shaped structure, and each electricity irritation mechanism electrically connects with control station respectively and controlled it by control station and use electricity condition.
Also including night soil-treatment mechanism, this night soil-treatment mechanism includes drawing and pulling type feces box, hangs tilting feces gear Plate and push-down feces scraper plate, drawing and pulling type feces box is horizontally installed on through outer gimbal support all trains under cage one end Fang Bingke extracts out from outer gimbal support, hangs under the treadmill outlet that tilting feces baffle plate is separately mounted to each training cage Side is also inclined to set, and its upper end is close with the crawler belt of treadmill, and lower end is connected with drawing and pulling type feces box, push-down Feces scraper plate is adnexa, for periodically manually being scraped in drawing and pulling type feces box by a small amount of feces fallen on base.
Bottom described outer gimbal support, corner is separately installed with universal wheel, each universal wheel equal belt lock catch fixed mechanism.
Described anterior-posterior balance training cage and left-right balance training cage are respectively two, and two left-right balance training cages are arranged In the side of outer gimbal support, two anterior-posterior balance training cages are arranged on the opposite side of outer gimbal support.
The present invention has the following advantages and feature:
(1) device includes the two training cages to different training functions, can be compared to each other;
(2) each runway speed independently controls, rat self-movement in each passage, will not be interfered, that Limiting factor between this is less;
(3) material of the different coefficients of friction such as Pasting fur, canvas, emery cloth or bristle on crawler belt, improves big Mus sense of touch and static sense, can meet different sensory function experiment demands, meet post-stroke and carry out after selecting to use The clinical status of early exercise;
(4) owing to being provided with swing governor motion and swinging governor motion, by reasonable set and control The amplitude swung around system and speed, can simulate balance plate training clinically more accurately, the most maximum Ensure that to limit effectiveness and the safety of training.
(5) the electricity irritation mechanism of training cage end prevents rat tail and head by card, and effectively prevents urine from making Become electricity irritation short-circuit failure phenomenon.
(6) the tilting feces baffle plate that hangs processed in real time all makes feces with the push-down feces scraper plate periodically processed Drop in drawing and pulling type feces box and focus on.
(7) treadmill have employed computer control system completely, can control balance and the motion of runway exactly Various parameters, obtain experimental data in real time, improve the analysis efficiency of experimental data, meet animal physiological function quantitative The development trend analyzed.
Accompanying drawing explanation
Fig. 1 is the population structure schematic diagram of brain injury in rats of the present invention sensation-balance-motion integrated training devices;
Fig. 2 be in the present invention before and after the population structure schematic diagram of balance training cage;
Fig. 3 be in the present invention before and after the drive mechanism schematic diagram of balance training cage;
Fig. 4 is the population structure schematic diagram of the left-right balance training cage in the present invention;
Fig. 5 is the drive mechanism schematic diagram of the left-right balance training cage in the present invention;
Fig. 6 is the left-right balance training cage cage body internal structure schematic diagram in the present invention;
Fig. 7 is the structural representation of the electricity irritation mechanism in the present invention.
Detailed description of the invention
See Fig. 1, coordinate and see Fig. 2, Fig. 4, the brain injury in rats sensation-balance-motion integrated instruction of the present invention Practicing device, including outer gimbal support 1, control station 2 and multiple training cage, control station 2 is connected to outer gimbal support 1 Outside, multiple training cages are mounted side by side in outer gimbal support, and multiple training cages include that at least one anterior-posterior balance is trained Cage 4 and at least one left-right balance train cage 5, are respectively equipped with treadmill 41,51 in each training cage;Put down front and back The lower section of weighing apparatus training cage 4 is provided with swing governor motion 6 and can drive treadmill 41 swing;Flat in left and right The lower section of weighing apparatus training cage 5 is provided with the governor motion 7 that swings and treadmill 51 can be driven to swing;Control station 2 With each treadmill 41,51, swing governor motion 6, the governor motion 7 that swings telecom-connect and control it Kinestate.
Control station 2 can do corresponding operation as requested on panel, in order to reaches desired result.First Row's knob is for controlling the rotating speed of each treadmill, and the rotating speed of each treadmill of centralized numerical display, accumulative operation The parameters such as time, distance travelled number;Second row knob is used for controlling electricity irritation voltage, and centralized numerical display electricity thorn Swash the parameter such as voltage, number of shocks;3rd row's knob swings speed for control, swing speed;And Centralized numerical display swings the parameters such as speed, swing speed;By all above instruction of USB port unloading Practice parameter.
Each training cage includes base and case respectively.The base 42 of anterior-posterior balance training cage 4 and outer gimbal support 1 Base plate 11 is rotatably connected, swing governor motion 6 be arranged on the base plate 11 of outer gimbal support and with front and back put down Base 42 transmission of weighing apparatus training cage is connected and can drive base swing;The base 52 of left-right balance training cage 5 Rotatably being connected with the two end plates of outer gimbal support 1, the governor motion 7 that swings is arranged on the base plate of outer gimbal support 1 Being connected on 11 and with base 52 transmission of left-right balance training cage to drive base to swing;Anterior-posterior balance is trained The case 43 of cage is fixedly linked with respective seat, and the case 53 of left-right balance training cage 5 is by support bar 532 It is fixedly linked with outer gimbal support;Each treadmill is separately mounted on the base of each training cage.
Each case is formed by enclosing transparent with machine glass, and has smooth inner surface, and case is arranged over Air-vent 431,531, case is respectively arranged at two ends with removable top cover 44,54.
Treadmill in the present invention is by the crawler type treadmill of driven by motor, with double on the crawler belt of crawler type treadmill Face glue has the fur of different coefficients of friction, canvas, gauze or bristle.
The case of anterior-posterior balance training cage 4 is square case, and respective activity top cover is flat cover;Left-right balance training cage The case of 5 is circular arc case, and respective activity top cover is circular arc lid;The base 52 of left-right balance training cage 5 Both sides are connected to circular arc side plate 521 (seeing Fig. 6), and two circular arc side plates 521 are sleeved on circular arc cover Shell 53 is interior and can swing along circular arc case.
Coordinating and see Fig. 7, the afterbody of each training cage is respectively equipped with electricity irritation mechanism 8, after this electricity irritation mechanism includes Plate 81 and multiple electricity irritation bar 82, back plate is arranged on the tail end of training cage, and multiple electricity irritation bar equidistant arrangement tilt Being arranged in back plate, electricity irritation bar 82 is in horizontal U-shaped structure, and each electricity irritation mechanism electrically connects with control station 1 respectively Controlled it by control station and use electricity condition.
Present invention additionally comprises night soil-treatment mechanism 9, this night soil-treatment mechanism 9 includes drawing and pulling type feces box 91, hangs Tilting feces baffle plate 92 and push-down feces scraper plate 93, drawing and pulling type feces box 91 is horizontal through outer gimbal support 1 It is arranged on the lower section of all training cage one end and can extract out from outer gimbal support, hanging tilting feces baffle plate 92 respectively Being arranged on below the treadmill outlet of each training cage and be inclined to set, its upper end is close with the crawler belt of treadmill, under End is connected with drawing and pulling type feces box, and push-down feces scraper plate 93 is adnexa, for periodically manually falling at base A small amount of feces scrape in drawing and pulling type feces box.
Bottom outer gimbal support 1 in the present invention, corner is separately installed with universal wheel (not shown out), each universal wheel All belt lock catch fixed mechanisms.
Before and after in the present invention, the concrete structure of balance training cage is as shown in Figures 2 and 3, its case 43 and base 42 are fixedly linked, and base 42 is rotatably connected with the base plate 11 of outer gimbal support 1, and treadmill 41 is arranged on base On 42, treadmill 41 is by crawler speed-regulating mechanism controls, and this crawler speed-regulating mechanism is driven big band by buncher 411 Wheel 412, drives to small pulley 414 by Timing Belt 413, and small pulley 414 is connected with the axis of crawler belt rod, real Existing crawler speed-regulating.Having round air-vent 431 above square case 43, two ends set removable top cover 44, and top cover has bar Shape air-vent 431, keeping rat can not escape at the volley simultaneously has again enough air.Train at anterior-posterior balance The lower section of cage 4 is provided with swing governor motion 6, and swing governor motion 6 is arranged on the base plate of outer gimbal support It is connected on 11 and with base 42 transmission of anterior-posterior balance training cage and can drive base swing.This swing is adjusted The implementation method of joint mechanism 6 is: motor 61 driving pulley 62, by Timing Belt 63 transmission, Timing Belt 63 drive power transmission shaft 65 to rotate, and power transmission shaft 65 drives double eccentric wheel 64 to rotate, and is driven by double-eccentric shaft 66 Being synchronized with the movement of double link 67;Double link 67 is connected with double-locking mechanism 68 transmission, and tow-locking structure 68 welds On base 42, it is connected with the combination of outer gimbal support base plate 11 circular arc by central shaft 69 below base 42, makes the end Seat 42 is with central shaft 69 for center of rotation swing.The swing feature of anterior-posterior balance training cage is: use double inclined Heart wheel+double-arm linkage is synchronized with the movement, and overcomes arm of force when anterior-posterior balance swings long, the difficult point that moment is bigger, Make treadmill swing the most steady.Electricity irritation mechanism 8 is positioned at the end of treadmill.Hang tilting feces baffle plate Feces on crawler belt 415 is fallen in drawing and pulling type feces box by 92 in real time, and adnexa push-down feces scraper plate 93 periodically will The feces on base 42 that falls pushes in drawing and pulling type feces box 91.
In the present invention left-right balance training cage 5 concrete structure as shown in Fig. 4, Fig. 5, Fig. 6, its case 53 Being fixedly linked with outer gimbal support by support bar 532, its base 52 is rotatable phase with the two end plates of outer gimbal support 1 Even, base 52 both sides are connected to circular arc side plate 521, and two circular arc side plates 521 are sleeved on circular arc Case 53 is interior and can swing along circular arc case.The governor motion 7 that swings is arranged on outer gimbal support 1 Being connected on base plate 11 and with base 52 transmission of left-right balance training cage to drive base to swing.Treadmill 51 are arranged on base 52, and treadmill 51 is by crawler speed-regulating mechanism controls, and this crawler speed-regulating mechanism is by speed governing electricity Machine 511 drives big belt wheel 512, drives to small pulley 514, small pulley 514 and crawler belt rod by Timing Belt 513 Axis be connected, it is achieved crawler belt 515 speed governing.Owing to the circular arc case 53 of left-right balance training cage 5 is by propping up Strut 532 is fixed together with the base plate 11 of outer gimbal support 1, when treadmill moves, and circular arc case 53 It is motionless.Having venthole 531 above circular arc case 53, two ends are equipped with the circular arc of with handles 541 Shape removable top cover 54, catches handle 541 can mention removable top cover 54, facilitates the operation of operator, front and back Also having venthole on cover, keeping rat can not escape at the volley simultaneously has again enough air.Swing regulation The implementation method of mechanism 7 is: taken turns by synchronization by being arranged on the motor 71 above outer gimbal support base plate 11 Drive mechanism 72 band dynamic bearing rotates, and utilizes two bearings 73 and an axle 74 to be fixed eccentric 75 position, Driving eccentric 75 drive link 76 of side, connecting rod 76 is flexibly connected with bar 77, drives bar 77 to transport Dynamic, bar 77 is directly fixed with base 52, makes treadmill realize swinging.The swing of left-right balance training cage is special Point is: uses single eccentric+single double connecting rod, it is achieved multiple degrees of freedom changes the direction of motion, drives treadmill Realization swings.Electricity irritation mechanism 8 is positioned at treadmill end, hangs tilting feces baffle plate 92 in real time by crawler belt Feces on 12 falls in drawing and pulling type feces box.Push-down feces scraper plate 93 the most manually cleaning drops down onto base 52 On feces.
One most preferred embodiment of the present invention is, anterior-posterior balance training cage 4 and left-right balance training cage 5 are respectively two Individual, two left-right balance training cages 5 are arranged on the side of outer gimbal support, and two anterior-posterior balance training cages 4 are arranged on The opposite side of outer gimbal support.
The present invention can realize the running training to rat, or the combined training that electricity irritation is combined with running training.Three To in training cage, big to experiment by the difference of the difference of jog mode, the difference of runway track material or angle Mus is trained and compares.In bascule, by rocking treadmill, rat is gone back while running training To be rocked by both sides and to be affected, the balanced capacity of observable rat.
The present invention is a kind of novel multi-functional rat device for healing and training meeting modern rehabilitation medicine theory, is used for Rat or the training of other animals, balance function training, sensory function training etc., not only can quantify accurately Training burden, and multifunction can be realized.Both can carry out the research of single recovery training method, can simulate really again The rehabilitation training pattern of sensation one balance one motion, reaches the purpose for the treatment of clinically.

Claims (10)

1. a brain injury in rats sensation-balance-motion integrated training devices, it is characterized in that: include outer gimbal support, control station and multiple training cage, control station is connected to the outside of outer gimbal support, multiple training cages are mounted side by side in outer gimbal support, multiple training cages include that at least one anterior-posterior balance training cage and at least one left-right balance train cage, are respectively equipped with treadmill in each training cage;It is provided with swing governor motion in the lower section of anterior-posterior balance training cage and can drive described treadmill swing;Being provided with, in the lower section of left-right balance training cage, the governor motion that swings can drive described treadmill to swing;Described control station and each treadmill, swing governor motion, the governor motion that swings telecom-connect and control its kinestate.
Brain injury in rats the most according to claim 1 sensation-balance-motion integrated training devices, it is characterised in that: described each training cage includes base and case respectively;The base of described anterior-posterior balance training cage is rotatably connected with the base plate of outer gimbal support, and described swing governor motion is arranged on the base plate of outer gimbal support and is connected with the base drive of anterior-posterior balance training cage and can drive base swing;The base of described left-right balance training cage is rotatably connected with the two end plates of outer gimbal support, described in the governor motion that swings be arranged on the base plate of outer gimbal support and be connected base can be driven to swing with the base drive of left-right balance training cage;The case of described anterior-posterior balance training cage is fixedly linked with respective seat, and the case of described left-right balance training cage is fixedly linked with outer gimbal support by support bar;Described treadmill is separately mounted on the base of each training cage.
Brain injury in rats the most according to claim 2 sensation-balance-motion integrated training devices, it is characterized in that: described case is formed by enclosing transparent with machine glass, and having smooth inner surface, case is arranged over air-vent, and case is respectively arranged at two ends with removable top cover.
Brain injury in rats the most according to claim 1 sensation-balance-motion integrated training devices, it is characterised in that: described treadmill is by the crawler type treadmill of driven by motor.
Brain injury in rats the most according to claim 4 sensation-balance-motion integrated training devices, it is characterised in that: with sticking double faced adhesive tape, there is the fur of different coefficients of friction, canvas, gauze or bristle on the crawler belt of described crawler type treadmill.
6. according to the brain injury in rats sensation-balance-motion integrated training devices described in Claims 2 or 3, it is characterised in that: the case of described anterior-posterior balance training cage is square case, and respective activity top cover is flat cover;The case of described left-right balance training cage is circular arc case, and respective activity top cover is circular arc lid;The base both sides of described left-right balance training cage are connected to circular arc side plate, in two circular arc side plates are sleeved on described circular arc case and can swing along circular arc case.
Brain injury in rats the most according to claim 1 sensation-balance-motion integrated training devices, it is characterized in that: the afterbody of each training cage is respectively equipped with electricity irritation mechanism, this electricity irritation mechanism includes back plate and multiple electricity irritation bar, back plate is arranged on the tail end of training cage, multiple electricity irritation bar equidistant arrangement are inclined and mounted in back plate, electricity irritation bar is horizontal U-shaped structure, and each electricity irritation mechanism electrically connects with control station respectively and controlled it by control station and use electricity condition.
Brain injury in rats the most according to claim 1 sensation-balance-motion integrated training devices, it is characterized in that: also include night soil-treatment mechanism, this night soil-treatment mechanism includes drawing and pulling type feces box, hang tilting feces baffle plate and push-down feces scraper plate, drawing and pulling type feces box is horizontally installed on the lower section of all training cage one end through outer gimbal support and can extract out from outer gimbal support, hang tilting feces baffle plate be separately mounted to below the treadmill outlet of each training cage and be inclined to set, its upper end is close with the crawler belt of treadmill, lower end is connected with drawing and pulling type feces box, push-down feces scraper plate is adnexa, manually a small amount of feces fallen on base is scraped in drawing and pulling type feces box for periodically.
Brain injury in rats the most according to claim 1 sensation-balance-motion integrated training devices, it is characterised in that: bottom described outer gimbal support, corner is separately installed with universal wheel, each universal wheel equal belt lock catch fixed mechanism.
Brain injury in rats the most according to claim 1 sensation-balance-motion integrated training devices, it is characterized in that: described anterior-posterior balance training cage and left-right balance training cage are respectively two, two left-right balance training cages are arranged on the side of outer gimbal support, and two anterior-posterior balance training cages are arranged on the opposite side of outer gimbal support.
CN201310413625.6A 2013-09-11 2013-09-11 Brain injury in rats sensation-balance-motion integrated training devices Expired - Fee Related CN104414826B (en)

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CN112957690B (en) * 2021-02-03 2021-12-14 台州职业技术学院 Multifunctional rehabilitation training device for rats with brain injury

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CN203279635U (en) * 2013-05-03 2013-11-13 同济大学 Self-induction multi-track animal experiment treadmill
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US5054427A (en) * 1989-09-21 1991-10-08 Hoover Judith L Insertable stacking pet toy maze
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CN201315789Y (en) * 2008-10-20 2009-09-30 淮北正华生物仪器设备有限公司 Multi-track animal testing running platform
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CN203507056U (en) * 2013-09-11 2014-04-02 上海理工大学 Device for feeling-balance-motion integration training of brain injury rats

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