CN104491986A - Polarity selection circuit applied to cardiac pacemaker - Google Patents
Polarity selection circuit applied to cardiac pacemaker Download PDFInfo
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- CN104491986A CN104491986A CN201410783277.6A CN201410783277A CN104491986A CN 104491986 A CN104491986 A CN 104491986A CN 201410783277 A CN201410783277 A CN 201410783277A CN 104491986 A CN104491986 A CN 104491986A
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Abstract
The invention relates to a polarity selection circuit applied to a cardiac pacemaker. The polarity selection circuit comprises a two-polarity selection circuit and a three-polarity selection circuit. Two-polarity and three-polarity selection is correctly performed through pace making, electrocardiograph signal collecting and cardiac impedance measuring which are realized by the same electrode lead. The circuit has the characteristics of one-way conduction and multiple channels, each functional signal can only be transmitted in a corresponding fixed channel, each function is implemented in a corresponding independent channel during a correct polarity selection, and each functional signal can be effectively isolated on the circuit. Moreover, a core circuit is constructed by a switching type MOS (Metal Oxide Semiconductor) tube, small signal loss, high isolating degree and high security are achieved. Therefore, the polarity selection circuit is suitable for large-area popularization and wide use.
Description
Technical field
The invention belongs to technical field of integrated circuits, be specifically related to a kind of polarity selecting circuit being applied to cardiac pacemaker.
Background technology
Cardiac pacemaker can be used for treating some due to diseases such as some arrhythmia caused heart dysfunctioies, and it is formed primarily of pacemaker and electrode cable two parts, after Pacemaker implantation human body, is connected with heart by electrode cable.Pacemaker impulse is sent to heart by the inner wires of electrode cable, is the anode of pacemaker; Another wires passes electrocardiosignal back pacemaker, is pacemaker negative electrode; Pacemaker impulse is also sent to heart by tissue by the shell of simultaneous pacing device.Increasing clinical data shows, by changing polarity of electrode, to produce the depolarization pacemaker impulse closest to heart intrinsic pacemaker impulse signal, more contribute to stable heart-rate, improves the therapeutic effect of cardiac pacemaker.Polarity selecting circuit can make cardiac pacemaker complete from pacemaker anode to pacemaker negative electrode, from pacemaker shell to pacemaker negative electrode, from pacemaker negative electrode to the function such as pace-making, heart impedance measurement the Different electrodes of pacemaker anode.More and more perfect along with cardiac pacemaker function, safe and reliable polarity selecting circuit is more and more important.
The selection of various polarity when patent U.S.No.4628934 achieves the pacemaker pace-making with multi-cavity electrode cable by a kind of circuit structure, but not there is ecg signal acquiring, polarity selection function that heart impedance is measured.
Patent U.S.No.6477417B1 achieves the selection with the pacemaker pace-making of multi-cavity electrode cable, the various polarity of ecg signal acquiring by a kind of circuit structure, but its pace-making and ecg signal acquiring function all need respective electrode cable.
Summary of the invention
The object of the invention is to overcome the shortcoming existed in above-mentioned prior art, a kind of polarity selecting circuit being applied to cardiac pacemaker is provided, there is the advantage that isolation is high, capacity of resisting disturbance is strong.
For achieving the above object, the present invention by the following technical solutions: comprise the circuit of bipolarity selection and the circuit of three polarity selection;
Described bipolarity selection circuit comprises: the first metal-oxide-semiconductor that source links together and the second metal-oxide-semiconductor, and the grid end of the first metal-oxide-semiconductor and the second metal-oxide-semiconductor is connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the first metal-oxide-semiconductor and the 3rd metal-oxide-semiconductor is all connected to the anode of pacing circuitry output; 3rd metal-oxide-semiconductor is connected with the source of the 4th metal-oxide-semiconductor, and the 3rd metal-oxide-semiconductor and the 4th metal-oxide-semiconductor grid end are connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the 2nd MOS is connected with pacemaker shell; The drain terminal of the 4th metal-oxide-semiconductor is connected with pacemaker anode; 5th is connected with the anode that the source of the 6th metal-oxide-semiconductor all exports with electrocardiogram acquisition circuit, and the 5th is connected the outfan of the control decoding circuit of its correspondence respectively with the 6th metal-oxide-semiconductor grid end; 5th metal-oxide-semiconductor drain terminal is connected with pacemaker shell, and the 6th metal-oxide-semiconductor drain terminal is connected with pacemaker anode; 7th metal-oxide-semiconductor is connected with the 8th metal-oxide-semiconductor source, and the 7th metal-oxide-semiconductor, the 8th metal-oxide-semiconductor grid end are connected on the control decoding circuit outfan of its correspondence altogether; The anode that 7th metal-oxide-semiconductor all exports with pacing circuitry with the 9th metal-oxide-semiconductor drain terminal is connected; 9th is connected with the tenth metal-oxide-semiconductor source; The grid end of the 9th metal-oxide-semiconductor and the tenth metal-oxide-semiconductor is connected on the control decoding circuit outfan of its correspondence altogether; The drain terminal of the 8th metal-oxide-semiconductor is connected with pacemaker shell; The drain terminal of the tenth metal-oxide-semiconductor is connected with pacemaker anode;
Three described polarity selecting circuits comprise: the 11 metal-oxide-semiconductor, the 13 metal-oxide-semiconductor and the 15 metal-oxide-semiconductor that drain terminal is all connected with pacing circuitry output plus terminal; 11 metal-oxide-semiconductor and the 12 metal-oxide-semiconductor grid end are connected on the high-voltage driving circuit outfan of its correspondence altogether; 12 metal-oxide-semiconductor source is connected with the 11 metal-oxide-semiconductor drain terminal, and the 12 metal-oxide-semiconductor drain terminal is connected with pacemaker shell; 13 metal-oxide-semiconductor source is connected with the 14 metal-oxide-semiconductor source, and two mos gate ends are connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the 14 metal-oxide-semiconductor is connected with the drain terminal of pacemaker anode with the 23 metal-oxide-semiconductor; The control decoding circuit outfan that the grid end of the 23 metal-oxide-semiconductor is corresponding with it is connected, and the negative terminal of the negative terminal that source and pacing circuitry export and impedance measuring circuit is connected; 15 metal-oxide-semiconductor source is connected with the 16 metal-oxide-semiconductor source, and two mos gate ends are connected on the high-voltage driving circuit outfan of its correspondence altogether, and the drain terminal of the 16 metal-oxide-semiconductor is connected with the 24 metal-oxide-semiconductor drain terminal with pacemaker negative electrode; The control decoding circuit that the grid end of the 24 metal-oxide-semiconductor is corresponding with it exports and is connected, and the negative terminal of the negative terminal that source and pacing circuitry export and impedance measuring circuit is connected; 17 metal-oxide-semiconductor, the 19 metal-oxide-semiconductor, the 21 metal-oxide-semiconductor drain terminal are all connected with impedance measuring circuit output plus terminal; 17 metal-oxide-semiconductor source is connected with the 18 metal-oxide-semiconductor source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 18 metal-oxide-semiconductor drain terminal is connected with pacemaker shell; 19 metal-oxide-semiconductor source is connected with the 20 metal-oxide-semiconductor source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 20 metal-oxide-semiconductor drain terminal is connected with pacemaker anode; 210 metal-oxide-semiconductor source is connected with the 22 metal-oxide-semiconductor source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 22 metal-oxide-semiconductor drain terminal is connected with pacemaker negative electrode.
The first described metal-oxide-semiconductor, the second metal-oxide-semiconductor, the 3rd metal-oxide-semiconductor, the 4th metal-oxide-semiconductor, the 11 metal-oxide-semiconductor, the 12 metal-oxide-semiconductor, the 13 metal-oxide-semiconductor, the 14 metal-oxide-semiconductor, the 15 metal-oxide-semiconductor and the 16 metal-oxide-semiconductor are the high voltage bearing switch type MOS of grid.
The 5th described metal-oxide-semiconductor, the 6th metal-oxide-semiconductor, the 7th metal-oxide-semiconductor, the 8th metal-oxide-semiconductor, the 9th metal-oxide-semiconductor, the tenth metal-oxide-semiconductor, the 17 metal-oxide-semiconductor, the 18 metal-oxide-semiconductor, the 19 metal-oxide-semiconductor, the 20 metal-oxide-semiconductor, the 21 metal-oxide-semiconductor, the 22 metal-oxide-semiconductor, the 23 metal-oxide-semiconductor and the 24 metal-oxide-semiconductor are the high voltage bearing switch type MOS of drain terminal.
The present invention has following beneficial effect: prior art of comparing, the present invention by sharing the pace-making of an electrode cable, ecg signal acquiring, heart impedance measure and correctly carry out bipolar, three grades of Sexual behavior mode; This circuit has the feature of one-way conduction multi-path, can ensure that each function signal is only transmitted in its fixing path, while correct polarity is selected, each function is completed in its independent path, effectively can isolate each function signal on circuit; And be made up of switching mode metal-oxide-semiconductor due to core circuit, the loss of signal is less, and isolation is high, and safety is good.Thus this device is applicable to spread and widely uses.
Further, because the first metal-oxide-semiconductor, the second metal-oxide-semiconductor, the 3rd metal-oxide-semiconductor, the 4th metal-oxide-semiconductor, the 11 metal-oxide-semiconductor, the 12 metal-oxide-semiconductor, the 13 metal-oxide-semiconductor, the 14 metal-oxide-semiconductor, the 15 metal-oxide-semiconductor and the 16 metal-oxide-semiconductor are the high voltage bearing switch type MOS of grid, thus there is low on-resistance
Further, because the 5th metal-oxide-semiconductor, the 6th metal-oxide-semiconductor, the 7th metal-oxide-semiconductor, the 8th metal-oxide-semiconductor, the 9th metal-oxide-semiconductor, the tenth metal-oxide-semiconductor, the 17 metal-oxide-semiconductor, the 18 metal-oxide-semiconductor, the 19 metal-oxide-semiconductor, the 20 metal-oxide-semiconductor, the 21 metal-oxide-semiconductor, the 22 metal-oxide-semiconductor, the 23 metal-oxide-semiconductor and the 24 metal-oxide-semiconductor are the high voltage bearing switch type MOS of drain terminal, thus there is low conducting resistance, supply voltage can drive.
Accompanying drawing explanation
Fig. 1 is the polarity choosing principles figure of cardiac pacemaker;
Fig. 2 is the circuit theory diagrams that the invention provides bipolarity selection;
Fig. 3 is the circuit theory diagrams that the invention provides three polarity selections;
Fig. 4 is the simulation result figure of circuit when STI=0, SEN=0 shown in Fig. 2;
Fig. 5 is the simulation result figure of circuit when STI=1, SEN=1 shown in Fig. 2;
Fig. 6 is the simulation result figure of circuit when STI=0, SEN=1 shown in Fig. 2;
Fig. 7 is the simulation result figure of circuit when STI=1, SEN=0 shown in Fig. 2;
Fig. 8 is the simulation result figure of circuit during the highest amplitude 6.2V of pacemaker impulse shown in Fig. 3;
Fig. 9 is the simulation result figure of circuit during the highest amplitude 6.75V of pacemaker impulse shown in Fig. 3;
Figure 10 is the simulation result figure of circuit during the highest amplitude 6.76V of pacemaker impulse shown in Fig. 3.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in further detail.
See Fig. 2,3, the present invention includes the circuit of bipolarity selection and the circuit of three polarity selection; Bipolarity selection circuit comprises: the first metal-oxide-semiconductor M1 that source links together and the second metal-oxide-semiconductor M2, and the grid end of the first metal-oxide-semiconductor M1 and the second metal-oxide-semiconductor M2 is connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the first metal-oxide-semiconductor M1 and the 3rd metal-oxide-semiconductor M3 is all connected to the anode of pacing circuitry output; 3rd metal-oxide-semiconductor M3 is connected with the source of the 4th metal-oxide-semiconductor M4, and the 3rd metal-oxide-semiconductor M3 and the 4th metal-oxide-semiconductor M4 grid end are connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the 2nd MOS is connected with pacemaker shell; The drain terminal of the 4th metal-oxide-semiconductor M4 is connected with pacemaker anode; 5th is connected with the anode that the source of the 6th metal-oxide-semiconductor M6 all exports with electrocardiogram acquisition circuit, and the 5th is connected the outfan of the control decoding circuit of its correspondence respectively with the 6th metal-oxide-semiconductor M6 grid end; 5th metal-oxide-semiconductor M5 drain terminal is connected with pacemaker shell, and the 6th metal-oxide-semiconductor M6 drain terminal is connected with pacemaker anode; 7th metal-oxide-semiconductor M7 is connected with the 8th metal-oxide-semiconductor M8 source, and the 7th metal-oxide-semiconductor M7, the 8th metal-oxide-semiconductor M8 grid end are connected on the control decoding circuit outfan of its correspondence altogether; The anode that 7th metal-oxide-semiconductor M7 all exports with pacing circuitry with the 9th metal-oxide-semiconductor M9 drain terminal is connected; 9th is connected with the tenth metal-oxide-semiconductor M10 source; The grid end of the 9th metal-oxide-semiconductor M9 and the tenth metal-oxide-semiconductor M10 is connected on the control decoding circuit outfan of its correspondence altogether; The drain terminal of the 8th metal-oxide-semiconductor M8 is connected with pacemaker shell; The drain terminal of the tenth metal-oxide-semiconductor M10 is connected with pacemaker anode;
Three polarity selecting circuits comprise: the 11 metal-oxide-semiconductor M11, the 13 metal-oxide-semiconductor M13 and the 15 metal-oxide-semiconductor M15 that drain terminal is all connected with pacing circuitry output plus terminal; 11 metal-oxide-semiconductor M11 and the 12 metal-oxide-semiconductor M12 grid end are connected on the high-voltage driving circuit outfan of its correspondence altogether; 12 metal-oxide-semiconductor M12 source is connected with the 11 metal-oxide-semiconductor M11 drain terminal, and the 12 metal-oxide-semiconductor M12 drain terminal is connected with pacemaker shell; 13 metal-oxide-semiconductor M13 source is connected with the 14 metal-oxide-semiconductor M14 source, and two mos gate ends are connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the 14 metal-oxide-semiconductor M14 is connected with the drain terminal of pacemaker anode with the 23 metal-oxide-semiconductor M23; The control decoding circuit outfan that the grid end of the 23 metal-oxide-semiconductor M23 is corresponding with it is connected, and the negative terminal of the negative terminal that source and pacing circuitry export and impedance measuring circuit is connected; 15 metal-oxide-semiconductor M15 source is connected with the 16 metal-oxide-semiconductor M16 source, and two mos gate ends are connected on the high-voltage driving circuit outfan of its correspondence altogether, and the drain terminal of the 16 metal-oxide-semiconductor M16 is connected with the 24 metal-oxide-semiconductor M24 drain terminal with pacemaker negative electrode; The control decoding circuit that the grid end of the 24 metal-oxide-semiconductor M24 is corresponding with it exports and is connected, and the negative terminal of the negative terminal that source and pacing circuitry export and impedance measuring circuit is connected; 17 metal-oxide-semiconductor M17, the 19 metal-oxide-semiconductor M19, the 21 metal-oxide-semiconductor M21 drain terminal are all connected with impedance measuring circuit output plus terminal; 17 metal-oxide-semiconductor M17 source is connected with the 18 metal-oxide-semiconductor M18 source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 18 metal-oxide-semiconductor M18 drain terminal is connected with pacemaker shell; 19 metal-oxide-semiconductor M19 source is connected with the 20 metal-oxide-semiconductor M20 source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 20 metal-oxide-semiconductor M20 drain terminal is connected with pacemaker anode; 210 metal-oxide-semiconductor M21 source is connected with the 22 metal-oxide-semiconductor M22 source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 22 metal-oxide-semiconductor M22 drain terminal is connected with pacemaker negative electrode.
First metal-oxide-semiconductor M1, the second metal-oxide-semiconductor M2, the 3rd metal-oxide-semiconductor M3, the 4th metal-oxide-semiconductor M4, the 11 metal-oxide-semiconductor M11, the 12 metal-oxide-semiconductor M12, the 13 metal-oxide-semiconductor M13, the 14 metal-oxide-semiconductor M14, the 15 metal-oxide-semiconductor M15 and the 16 metal-oxide-semiconductor M16 are the high voltage bearing switch type MOS of grid.5th metal-oxide-semiconductor M5, the 6th metal-oxide-semiconductor M6, the 7th metal-oxide-semiconductor M7, the 8th metal-oxide-semiconductor M8, the 9th metal-oxide-semiconductor M9, the tenth metal-oxide-semiconductor M10, the 17 metal-oxide-semiconductor M17, the 18 metal-oxide-semiconductor M18, the 19 metal-oxide-semiconductor M19, the 20 metal-oxide-semiconductor M20, the 21 metal-oxide-semiconductor M21, the 22 metal-oxide-semiconductor M22, the 23 metal-oxide-semiconductor M23 and the 24 metal-oxide-semiconductor M24 are the high voltage bearing switch type MOS of drain terminal.
This example circuit-level emulation adopt be HHNEC 0.35um BCD technique, and use the Spectre of Cadence company to emulate under ADE (DA for analog IC simulation software) environment to obtain, the supply voltage of circuit working is 2.8V.
24 LDNMOS pipes are comprised altogether referring to figs. 2 and 3 the present invention.Notice that the scope that the present invention protects is not limited to example described herein.In these examples, the LDNMOS that metal-oxide-semiconductor is all, can use LDPMOS, general switching mode metal-oxide-semiconductor etc. to replace LDNMOS certainly.
Fig. 2 is for being applicable to the circuit providing cardiac pacemaker bipolarity to select, and its work process comprises: the ambipolar selection of pacing circuitry; The bipolarity of heart impedance measuring circuit is selected; The bipolarity of ecg signal acquiring circuit is selected.Bipolarity for pacing circuitry is selected: first receive STI_L signal and make STI Polarity Control effective; As STI=0, P1 port input high pressure, the NMOS first metal-oxide-semiconductor M1 conducting that drain terminal is connected with pacing circuitry output plus terminal, source is connected with the first metal-oxide-semiconductor M1 source, the NMOS second metal-oxide-semiconductor M2 conducting that drain terminal is connected with pacemaker metal shell, all the other each metal-oxide-semiconductor grid all connect 0 level, are off state, so just obtain the pacemaker shell-pacemaker negative electrode polarity of pace-making; As STI=1, P2 port input high pressure, NMOS the 3rd metal-oxide-semiconductor M3 conducting that drain terminal is connected with pacing circuitry output plus terminal, source is connected with the 3rd metal-oxide-semiconductor M3 source, NMOS the 4th metal-oxide-semiconductor M4 conducting that drain terminal is connected with heart anode, all the other each metal-oxide-semiconductor grid all connect 0 level, are off state, so just obtain the anode-negative electrode polarity of pace-making; Select polarity chron at pace-making simultaneously, ecg signal acquiring path and heart impedance Measure Channel all turn off, because pacemaker impulse highest amplitude is within 8V, and the LDNMOS drain terminal all high pressure of resistance to 30V adopted, ensure that pacemaker impulse can not pass back in ecg signal acquiring circuit and heart impedance measuring circuit completely, there is isolation well.The bipolarity of pacing circuitry selects truth table as shown in table 1.
The bipolarity of table 1 pacing circuitry selects truth table
Bipolarity for ecg signal acquiring circuit is selected: first receive SEN_L signal and make SEN Polarity Control effective; As SEN=0, P3 port input supply voltage, source is connected with ecg signal acquiring circuit output plus terminal, NMOS the 5th metal-oxide-semiconductor M5 conducting that drain terminal is connected with pacemaker shell CAN, all the other each metal-oxide-semiconductor grid all connect 0 level, be off state, so just obtain the pacemaker shell-pacemaker negative electrode polarity of ecg signal acquiring; As SEN=1, P4 port input supply voltage, source is connected with ecg signal acquiring circuit output plus terminal, NMOS the 6th metal-oxide-semiconductor M6 conducting that drain terminal is connected with heart anode, all the other each metal-oxide-semiconductor grid all connect 0 level, be off state, so just obtain the pacemaker anode-negative electrode polarity of ecg signal acquiring; Select polarity chron at ecg signal acquiring circuit, pace-making path and heart impedance Measure Channel all turn off, and electrocardiosignal is the highest only has tens millivolts, does not almost affect other circuit simultaneously.Ecg signal acquiring polarity selects truth table as shown in table 2.
Table 2 ecg signal acquiring bipolarity selects truth table
Bipolarity for heart impedance measuring circuit is selected: first receive RM_L signal and make RM Polarity Control effective; As RM=0, P5 port input supply voltage, NMOS the 7th metal-oxide-semiconductor M7 conducting that drain terminal is connected with heart impedance measuring circuit output plus terminal, source is connected with the 7th metal-oxide-semiconductor M7 source, NMOS the 8th metal-oxide-semiconductor M8 conducting that drain terminal is connected with pacemaker metal shell, all the other each metal-oxide-semiconductor grid all connect 0 level, are off state, so just obtain pacemaker shell-pacemaker negative electrode polarity that heart impedance is measured; As RM=1, P6 port input supply voltage, NMOS the 9th metal-oxide-semiconductor M9 conducting that drain terminal is connected with heart impedance measuring circuit output plus terminal, source is connected with the 9th metal-oxide-semiconductor M9 source, NMOS the tenth metal-oxide-semiconductor M10 conducting that drain terminal is connected with heart anode, all the other each metal-oxide-semiconductor grid all connect 0 level, are off state, so just obtain pacemaker anode-pacemaker negative electrode polarity that heart impedance is measured; Heart impedance is measured and is selected polarity chron simultaneously, and all the other two paths all turn off, and have isolation well.The bipolarity that heart impedance is measured selects truth table as shown in table 3.
The bipolarity of table 3 heart impedance measuring circuit selects truth table
Fig. 3 is for being applicable to the circuit providing cardiac pacemaker three polarity to select, and its work process comprises: the selection of three polarity of pacing circuitry; The selection of three polarity of heart impedance measuring circuit.Three polarity for pacing circuitry are selected: first receive STI_L and make STI Polarity Control effective; As STI=00, P7 port input high pressure, NMOS the 11 metal-oxide-semiconductor M11 conducting that drain terminal is connected with pacing circuitry output plus terminal, source is connected with M11 source, NMOS the 12 metal-oxide-semiconductor M12 conducting that drain terminal is connected with pacemaker metal shell; P14 port input high pressure, source is connected with pacing circuitry negative terminal, the 24 metal-oxide-semiconductor M24 conducting that drain terminal is connected with heart negative terminal, and all the other each metal-oxide-semiconductor grid all connect 0 level, be off state, so just obtain the shell-pacemaker negative electrode polarity of pace-making; As STI=01, P8 port input high pressure, NMOS the 13 metal-oxide-semiconductor M13 conducting that drain terminal is connected with pacing circuitry output plus terminal, source is connected with the 13 metal-oxide-semiconductor M13 source, NMOS the 14 metal-oxide-semiconductor M14 conducting that drain terminal is connected with heart anode; P14 port input high pressure, source is connected with pacing circuitry negative terminal, the 24 metal-oxide-semiconductor M24 conducting that drain terminal is connected with heart negative terminal, and all the other each metal-oxide-semiconductor grid all connect 0 level, are off state, so just obtain the anode-negative electrode polarity of pace-making; As STI=10, P9 port input high pressure, NMOS the 15 metal-oxide-semiconductor M15 conducting that drain terminal is connected with pacing circuitry output plus terminal, source is connected with M15 source, NMOS the 16 metal-oxide-semiconductor M16 conducting that drain terminal is connected with heart negative terminal; P13 port input high pressure, source is connected with pacing circuitry negative terminal, the 23 metal-oxide-semiconductor M23 conducting that drain terminal is connected with heart anode, and all the other each metal-oxide-semiconductor grid all connect 0 level, are off state, so just obtain the negative electrode-anode polarity of pace-making.The truth table that pacing circuitry three polarity is selected is as shown in table 4.
Table 4 pacing circuitry three polarity selects truth table
Three polarity for heart impedance measuring circuit are selected: first receive RM_L and make RM Polarity Control effective; As RM=00, P10 port input high pressure, NMOS the 17 metal-oxide-semiconductor M17 conducting that drain terminal is connected with heart impedance measuring circuit output plus terminal, source is connected with the 17 metal-oxide-semiconductor M17 source, NMOS the 18 metal-oxide-semiconductor M18 conducting that drain terminal is connected with pacemaker metal shell; P14 port input high pressure, source and heart impedance measuring circuit export negative terminal and are connected, the 24 metal-oxide-semiconductor M24 conducting that drain terminal is connected with heart negative terminal, all the other each metal-oxide-semiconductor grid all connect 0 level, be off state, so just obtain pacemaker shell-pacemaker negative electrode polarity that heart impedance is measured; As RM=01, P11 port input high pressure, NMOS the 19 metal-oxide-semiconductor M19 conducting that drain terminal is connected with heart impedance measuring circuit output plus terminal, source is connected with the 19 metal-oxide-semiconductor M19 source, NMOS the 20 metal-oxide-semiconductor M20 conducting that drain terminal is connected with heart anode; P14 port input high pressure, source and heart impedance measuring circuit export negative terminal and are connected, the 24 metal-oxide-semiconductor M24 conducting that drain terminal is connected with heart negative terminal, all the other each metal-oxide-semiconductor grid all connect 0 level, be off state, so just obtain pacemaker anode-negative electrode polarity that heart impedance is measured; As RM=10, P12 port input high pressure, NMOS the 21 metal-oxide-semiconductor M21 conducting that drain terminal is connected with impedance measuring circuit output plus terminal, source is connected with the 21 metal-oxide-semiconductor M21 source, NMOS the 22 metal-oxide-semiconductor M22 conducting that drain terminal is connected with heart negative terminal; P13 port input high pressure, source is connected with heart impedance measuring circuit negative terminal, the 23 metal-oxide-semiconductor M23 conducting that drain terminal is connected with heart anode, all the other each metal-oxide-semiconductor grid all connect 0 level, be off state, so just obtain pacemaker negative electrode-pacemaker anode polarity that heart impedance is measured.The truth table that heart impedance measuring circuit three polarity is selected is as shown in table 5.
Table 5 heart impedance measuring circuit three polarity selects truth table
The simulation result figure that Fig. 4, Fig. 5, Fig. 6, Fig. 7 are circuit shown in Fig. 2, this figure are included in the pace-making of four kinds of various combination polarity, the simulation result of ecg signal acquiring under 2.8V supply voltage.In the diagram, STI=0, when SEN=0 institute diagram is pace-making, ecg signal acquiring is pacemaker shell-pacemaker negative electrode, can find out that pace-making only had faint crosstalk before ecg signal acquiring starts, be reflected in this crosstalk highest amplitude of ecg signal acquiring outfan only 56.09uV normally export 996.6mV compared to it, interference ratio only 0.0056%; The crosstalk highest amplitude only 36.03uV of pace-making to ecg signal acquiring can be found out, interference ratio only 0.0036% in Fig. 5, STI=1, SEN=1 institute diagram; Simultaneously under these four kinds of combinations of polarities modes pacemaker impulse and ecg signal acquiring result waveform all correct; The crosstalk highest amplitude only 49.2uV of pace-making to ecg signal acquiring can be found out, interference ratio only 0.0049% in Fig. 6, STI=0, SEN=1 institute diagram; The crosstalk highest amplitude only 43.4uV of pace-making to ecg signal acquiring can be found out, interference ratio only 0.0044% in Fig. 7, STI=1, SEN=0 institute diagram.
The simulation result figure that Fig. 8, Fig. 9, Figure 10 are circuit shown in Fig. 3, be under 2.8V supply voltage, pace-making, heart impedance measure the emulation between two kinds of functions, comprise the simulation result under three kinds of polarity: from Fig. 8 to Figure 10, be followed successively by pacemaker shell-pacemaker negative electrode, pacemaker anode-negative electrode, pacemaker negative electrode-anode.At 1K cardiac workload resistance, from the shell of pacemaker shown in Fig. 8-pacemaker negative electrode polarity, pacemaker impulse highest amplitude 6.2V, during pace-making, heart impedance measurement output waveform still keeps stable does not have disturbance, and when heart impedance is measured, Output rusults is 1.05V; From the anode of pacemaker shown in Fig. 9-negative electrode polarity, pacemaker impulse highest amplitude 6.75V, during pace-making, heart impedance measurement output waveform still keeps stable does not have disturbance, and when heart impedance is measured, Output rusults is 1.05V; From the negative electrode-anode polarity of pacemaker shown in Figure 10, pacemaker impulse highest amplitude 6.76V, during pace-making, heart impedance measurement output waveform still keeps stable does not have disturbance, and when heart impedance is measured, Output rusults is 1.05V; Can find out that three kinds of polarity impedance measurements keep identical, there is good concordance, show that three kinds of heart impedances measure polarity correct, meet the demands for the pacemaker impulse difference of three kinds of polarity is less simultaneously.
In sum, the selecting properly that the present invention can realize that two-chamber is bipolar, three poles etc. have the polarity of the functions such as pace-making in the pacemaker of various polarity, heart impedance measurement, ecg signal acquiring, make the signal of each function transmit in passage special separately simultaneously, circuit achieves the separation of each function signal, each function isolation is high, the advantages such as crosstalk is little.The present invention is applicable to the cardiac pacemaker with various polarity.
Claims (3)
1. be applied to a polarity selecting circuit for cardiac pacemaker, it is characterized in that: comprise the circuit of bipolarity selection and the circuit of three polarity selection;
Described bipolarity selection circuit comprises: the first metal-oxide-semiconductor (M1) that source links together and the second metal-oxide-semiconductor (M2), and the grid end of the first metal-oxide-semiconductor (M1) and the second metal-oxide-semiconductor (M2) is connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the first metal-oxide-semiconductor (M1) and the 3rd metal-oxide-semiconductor (M3) is all connected to the anode of pacing circuitry output; 3rd metal-oxide-semiconductor (M3) is connected with the source of the 4th metal-oxide-semiconductor (M4), and the 3rd metal-oxide-semiconductor (M3) and the 4th metal-oxide-semiconductor (M4) grid end are connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the 2nd MOS is connected with pacemaker shell; The drain terminal of the 4th metal-oxide-semiconductor (M4) is connected with pacemaker anode; 5th is connected with the anode that the source of the 6th metal-oxide-semiconductor (M6) all exports with electrocardiogram acquisition circuit, and the 5th is connected the outfan of the control decoding circuit of its correspondence respectively with the 6th metal-oxide-semiconductor (M6) grid end; 5th metal-oxide-semiconductor (M5) drain terminal is connected with pacemaker shell, and the 6th metal-oxide-semiconductor (M6) drain terminal is connected with pacemaker anode; 7th metal-oxide-semiconductor (M7) is connected with the 8th metal-oxide-semiconductor (M8) source, and the 7th metal-oxide-semiconductor (M7), the 8th metal-oxide-semiconductor (M8) grid end are connected on the control decoding circuit outfan of its correspondence altogether; The anode that 7th metal-oxide-semiconductor (M7) all exports with pacing circuitry with the 9th metal-oxide-semiconductor (M9) drain terminal is connected; 9th is connected with the tenth metal-oxide-semiconductor (M10) source; The grid end of the 9th metal-oxide-semiconductor (M9) and the tenth metal-oxide-semiconductor (M10) is connected on the control decoding circuit outfan of its correspondence altogether; The drain terminal of the 8th metal-oxide-semiconductor (M8) is connected with pacemaker shell; The drain terminal of the tenth metal-oxide-semiconductor (M10) is connected with pacemaker anode;
Three described polarity selecting circuits comprise: the 11 metal-oxide-semiconductor (M11), the 13 metal-oxide-semiconductor (M13) and the 15 metal-oxide-semiconductor (M15) that drain terminal is all connected with pacing circuitry output plus terminal; 11 metal-oxide-semiconductor (M11) and the 12 metal-oxide-semiconductor (M12) grid end are connected on the high-voltage driving circuit outfan of its correspondence altogether; 12 metal-oxide-semiconductor (M12) source is connected with the 11 metal-oxide-semiconductor (M11) drain terminal, and the 12 metal-oxide-semiconductor (M12) drain terminal is connected with pacemaker shell; 13 metal-oxide-semiconductor (M13) source is connected with the 14 metal-oxide-semiconductor (M14) source, and two mos gate ends are connected on the high-voltage driving circuit outfan of its correspondence altogether; The drain terminal of the 14 metal-oxide-semiconductor (M14) is connected with the drain terminal of pacemaker anode with the 23 metal-oxide-semiconductor (M23); The control decoding circuit outfan that the grid end of the 23 metal-oxide-semiconductor (M23) is corresponding with it is connected, and the negative terminal of the negative terminal that source and pacing circuitry export and impedance measuring circuit is connected; 15 metal-oxide-semiconductor (M15) source is connected with the 16 metal-oxide-semiconductor (M16) source, two mos gate ends are connected on the high-voltage driving circuit outfan of its correspondence altogether, and the drain terminal of the 16 metal-oxide-semiconductor (M16) is connected with the 24 metal-oxide-semiconductor (M24) drain terminal with pacemaker negative electrode; The control decoding circuit that the grid end of the 24 metal-oxide-semiconductor (M24) is corresponding with it exports and is connected, and the negative terminal of the negative terminal that source and pacing circuitry export and impedance measuring circuit is connected; 17 metal-oxide-semiconductor (M17), the 19 metal-oxide-semiconductor (M19), the 21 metal-oxide-semiconductor (M21) drain terminal are all connected with impedance measuring circuit output plus terminal; 17 metal-oxide-semiconductor (M17) source is connected with the 18 metal-oxide-semiconductor (M18) source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 18 metal-oxide-semiconductor (M18) drain terminal is connected with pacemaker shell; 19 metal-oxide-semiconductor (M19) source is connected with the 20 metal-oxide-semiconductor (M20) source, and grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 20 metal-oxide-semiconductor (M20) drain terminal is connected with pacemaker anode; 210 metal-oxide-semiconductor (M21) source is connected with the 22 metal-oxide-semiconductor (M22) source, grid end is connected on the outfan of the control decoding circuit of its correspondence altogether, and the 22 metal-oxide-semiconductor (M22) drain terminal is connected with pacemaker negative electrode.
2. a kind of polarity selecting circuit being applied to cardiac pacemaker according to claim 1, is characterized in that: described the first metal-oxide-semiconductor (M1), the second metal-oxide-semiconductor (M2), the 3rd metal-oxide-semiconductor (M3), the 4th metal-oxide-semiconductor (M4), the 11 metal-oxide-semiconductor (M11), the 12 metal-oxide-semiconductor (M12), the 13 metal-oxide-semiconductor (M13), the 14 metal-oxide-semiconductor (M14), the 15 metal-oxide-semiconductor (M15) and the 16 metal-oxide-semiconductor (M16) are the high voltage bearing switch type MOS of grid.
3. a kind of polarity selecting circuit being applied to cardiac pacemaker according to claim 1, it is characterized in that: the 5th described metal-oxide-semiconductor (M5), 6th metal-oxide-semiconductor (M6), 7th metal-oxide-semiconductor (M7), 8th metal-oxide-semiconductor (M8), 9th metal-oxide-semiconductor (M9), tenth metal-oxide-semiconductor (M10), 17 metal-oxide-semiconductor (M17), 18 metal-oxide-semiconductor (M18), 19 metal-oxide-semiconductor (M19), 20 metal-oxide-semiconductor (M20), 21 metal-oxide-semiconductor (M21), 22 metal-oxide-semiconductor (M22), 23 metal-oxide-semiconductor (M23) and the 24 metal-oxide-semiconductor (M24) are the high voltage bearing switch type MOS of drain terminal.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107485784A (en) * | 2017-06-19 | 2017-12-19 | 西安交通大学 | A kind of anti-crosstalk potential circuit applied to Implanted cardiac pacemaker |
| CN111093761A (en) * | 2017-09-15 | 2020-05-01 | 美敦力公司 | Electrode for intracardiac pacemaker |
| WO2021232788A1 (en) * | 2020-05-21 | 2021-11-25 | 中国科学院深圳先进技术研究院 | Pacemaking switching circuit, pacemaking switching apparatus, and implantable cardiac pacemaker |
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| US4628934A (en) * | 1984-08-07 | 1986-12-16 | Cordis Corporation | Method and means of electrode selection for pacemaker with multielectrode leads |
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| CN107485784A (en) * | 2017-06-19 | 2017-12-19 | 西安交通大学 | A kind of anti-crosstalk potential circuit applied to Implanted cardiac pacemaker |
| CN107485784B (en) * | 2017-06-19 | 2020-10-27 | 西安交通大学 | Anti-crosstalk voltage circuit applied to implantable cardiac pacemaker |
| CN111093761A (en) * | 2017-09-15 | 2020-05-01 | 美敦力公司 | Electrode for intracardiac pacemaker |
| CN111093761B (en) * | 2017-09-15 | 2023-10-13 | 美敦力公司 | Electrode for intracardiac pacemaker |
| WO2021232788A1 (en) * | 2020-05-21 | 2021-11-25 | 中国科学院深圳先进技术研究院 | Pacemaking switching circuit, pacemaking switching apparatus, and implantable cardiac pacemaker |
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| CN104491986B (en) | 2016-08-17 |
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