CN104523748A - Compound iodine disinfectant and preparation method and application thereof - Google Patents
Compound iodine disinfectant and preparation method and application thereof Download PDFInfo
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- CN104523748A CN104523748A CN201510002882.XA CN201510002882A CN104523748A CN 104523748 A CN104523748 A CN 104523748A CN 201510002882 A CN201510002882 A CN 201510002882A CN 104523748 A CN104523748 A CN 104523748A
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- iodine
- disinfectant solution
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- hibitane
- disinfectant
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention provides compound iodine disinfectant. The active constituent of the compound iodine disinfectant comprises iodine and chlorhexidine, a solvent is water, and the solubilizer of the compound iodine disinfectant at least comprises polyoxyethylated castor oil. The solubilizer is additionally used in a current known iodine and chlorhexidine compound disinfection solution product. According to the compound iodine disinfectant, different solubilizers are utilized at the experiment initial stage, although all the solubilizers are commonly used in the field, it is found in the experiment that when the polyoxyethylated castor oil is selected as the solubilizer, the antibacterial ability of the iodine-chlorhexidine compound iodine disinfectant can be obviously improved, and the improvement effect on the antibacterial ability to certain specific bacteria like salmonella is even beyond the expect.
Description
Technical field
The present invention relates to a kind of compound iodine disinfectant solution and its production and use.
Background technology
Infect, refer to that the pathogen such as antibacterial, virus, fungus, parasite invades local organization caused by human body or systemic inflammatory reaction, especially bacteriological infection is comparatively common.Sterilization is the important means of effectively preventing bacteriological infection.
Common sterile products has ethanol, povidone iodine, hibitane iodine composite disinfecting product.Wherein, hibitane iodine composite disinfecting product is mixed with by iodine and hibitane to form, its bactericidal effect compared with hibitane or iodine more powerful, there is broad-spectrum bactericidal action well.
Number of patent application: 00111557.x discloses a kind of disinfectant solution, and be made up of available iodine, hibitane, polyvinyl chloride nonylphenolether and distilled water, sterilizing rate reaches as high as 99.32%.On the basis of above-mentioned patent, number of patent application: in 201310658586.6, adds alkylphenol polyoxyethylene and Tx-10 alkyl acid, improves broad-spectrum sterilization effect, also add the aquatic defoamer of MDZ0, to reach the effect of hydrotropy and raising active component simultaneously.
Summary of the invention
Compound iodine disinfectant solution that the object of the present invention is to provide a kind of antibacterial effect more good and preparation method thereof.
The invention provides a kind of compound iodine disinfectant solution, its active component comprises iodine and hibitane, and solvent is water, at least containing polyoxyethylene castor oil (CAS:61791-12-6, CremophorEL) in its solubilizing agent.
Further, described active component is iodine and hibitane.
Further, solubilizing agent is selected from polyoxyethylene castor oil.
Wherein, in every 100ml disinfectant solution, amount of iodine counts 0.10 ~ 0.7gg with available iodine, and hibitane content is 0.10 ~ 0.25g, polyoxyethylene castor oil content is 1 ~ 6g.
Further, in every 100ml disinfectant solution, amount of iodine counts 6g with available iodine, and hibitane content is 0.15g, polyoxyethylene castor oil content is 3g.
Wherein, described iodine adds with povidone iodine, iodo-polyalcohol ether form; Described hibitane adds with chlorhexidine acetate, chlorhexidine hydrochloride, citric acid hibitane or chlorhexidine gluconate form.
Further, described iodine adds fashionable with povidone iodine, described hibitane with chlorhexidine acetate form, and in every 100ml disinfectant solution, povidone iodine is 6g, chlorhexidine acetate is 0.15g.
Wherein, also glycerol, PEG-1000 (effect of agent of can playing stably) is contained in described solvent.
Further, also 1 ~ 6g glycerol, 1 ~ 6g PEG-1000 is contained in every 100ml disinfectant solution.
Further, also 3g glycerol, 3g PEG-1000 is contained in every 100ml disinfectant solution.
Present invention also offers the preparation method of above-mentioned compound iodine disinfectant solution, it comprises following operating procedure:
(1) iodine is dissolved in part water, obtains solution I;
(2) hibitane, solubilizing agent, PEG-1000 and glycerol are dissolved in part water, obtain solution II;
(3) solution II mixed homogeneously with I, add water standardize solution, to obtain final product.
Present invention also offers the purposes of skin disinfectant for external use of above-mentioned compound iodine disinfectant solution preparation antibacterium or fungus.
Wherein, described antibacterial is escherichia coli, staphylococcus aureus, Salmonella, shigella or bacillus subtilis; Described fungus is Candida albicans.
Further, described antibacterial is Salmonella or shigella.
Present invention also offers a kind of sterile products, it is prepared from by above-mentioned compound iodine disinfectant solution and disinfectant solution carrier combinations.
Further, described disinfectant solution carrier is selected from cotton balls, gauze etc.
In current known iodine, hibitane composite disinfecting liquid product, employ solubilizing agent more.The present invention also using different solubilizing agents at the experiment initial stage, although various solubilizing agent is all the kind that this area is commonly used, but, but find unexpectedly in experiment, when selecting polyoxyethylene castor oil to be solubilizing agent, the antibacterial ability of iodo-hibitane composite disinfectant can be significantly improved, especially to the antibacterial ability castering action of some specific bacteria especially beyond expection, as Salmonella.
Salmonellosis refers to the general name multi-form to the mankind, domestic animal and wild birds and beasts caused by all kinds Salmonella.Infect the people of Salmonella or the fecal pollution food of bacillicarrier, Crinis Carbonisatus uncooked food can be made poisoning.According to statistics in the bacterial species alimentary toxicosis of countries in the world, the normal row umber one of salmonellal alimentary toxicosis.China hinterland is also first place with Salmonella, and the Salmonella poisoning lethal main cause that is U.S. Food.Obviously, compound iodine disinfectant solution of the present invention, to the special antibacterial activity of Salmonella, more effectively can being avoided the mankind or zoogenetic infection Salmonella, providing possibility for effectively preventing salmonellosis.
Detailed description of the invention
The preparation of embodiment 1 compound iodine disinfectant solution
Prescription:
PVP-I 6g, chlorhexidine acetate 0.15g, polyoxyethylene castor oil 3g, PEG-1000 3g, glycerol 3g, water add to 100ml.
Preparation method:
(1) iodine is dissolved in 60ml water, obtains solution I;
(2) hibitane, solubilizing agent, PEG-1000 and glycerol are dissolved in 30ml water, obtain solution II;
(3) solution II is mixed homogeneously with I, add water to 100ml, to obtain final product.
The preparation of embodiment 2 compound iodine disinfectant solution
Prescription:
PVP-I 4g, chlorhexidine acetate 0.20g, polyoxyethylene castor oil 2g, PEG-1000 2g, glycerol 4g, water add to 100ml.
Preparation method:
(1) iodine is dissolved in 60ml water, obtains solution I;
(2) hibitane, solubilizing agent, PEG-1000 and glycerol are dissolved in 30ml water, obtain solution II;
(3) solution II is mixed homogeneously with I, add water to 100ml, to obtain final product.
The preparation of embodiment 3 compound iodine disinfectant solution
Prescription:
PVP-I 3g, chlorhexidine acetate 0.25g, polyoxyethylene castor oil 5g, PEG-1000 4g, glycerol 3g, water add to 100ml.
Preparation method:
(1) iodine is dissolved in 60ml water, obtains solution I;
(2) hibitane, solubilizing agent, PEG-1000 and glycerol are dissolved in 30ml water, obtain solution II;
(3) solution II is mixed homogeneously with I, add water to 100ml, to obtain final product.
Situation is investigated in solubilizing agent in embodiment 4 compound iodine disinfectant solution
In early-stage Study process, employ different solubilizing agent kinds, concrete solubilizing agent kind is as follows:
1) Tween 80
2) SDS (dodecyl sodium sulfate)
3) AES (AES)
4) AEO-9 (alkyl alcohol ethoxylates)
5) polyoxyethylene castor oil
6) add without solubilizing agent
The experiment that the product mentioned in the compound iodine disinfectant solution different solubilizing agent prepared and prior art carries out under equal conditions is compared, its result following (disinfectant solution experimental concentration: 1%):
Bacteriostatic experiment result table under the compound iodine disinfectant solution of the different solubilizing agent of table 1 and commercially available prod equal conditions
Note: it is all people's pathogenic strain that the present invention tests antibacterial used
As can be seen from above-mentioned experiment:
(1), after adding solubilizing agent, the fungistatic effect of compound iodine disinfectant solution can be improved.
(2) disinfectant solution adding different solubilizing agent is compared, found that, after different solubilizing agent adds, also larger difference be there occurs to the inhibitory action of different microorganisms, particularly very big on the inhibitory action impact of gram negative bacteria (as escherichia coli, Salmonella, shigella) and fungus (as Candida albicans).
(3) the present invention in an experiment, and have selected commercially available compound iodine disinfecting cotton swab and iodine liquid in contrast, found that, commercially available compound iodine sterile products is also fainter to the inhibitory action of Salmonella.Same, during solubilizing agent in the present invention beyond choice for use polyoxyethylene castor oil, also effectively cannot suppress Salmonella.When only only having selection polyoxyethylene castor oil to be solubilizing agent, can significantly improve the inhibitory action of compound disinfectant to Salmonella, this result is significantly better than using the solubilizing agent of other kinds and commercially available sterile products.
Claims (10)
1. a compound iodine disinfectant solution, is characterized in that: active component comprises iodine and hibitane, and solvent is water, at least containing polyoxyethylene castor oil in its solubilizing agent.
2. compound iodine disinfectant solution according to claim 1, is characterized in that: described solubilizing agent is selected from polyoxyethylene castor oil.
3. compound iodine disinfectant solution according to claim 1, is characterized in that: in every 100ml disinfectant solution, amount of iodine counts 0.10 ~ 0.7g with available iodine, and hibitane content is 0.10 ~ 0.25g, polyoxyethylene castor oil content is 1 ~ 6g; Further, in every 100ml disinfectant solution, amount of iodine counts 0.20g with available iodine, and hibitane content is 0.15g, polyoxyethylene castor oil content is 3g.
4. compound iodine disinfectant solution according to claims 1 to 3, is characterized in that: described iodine adds with povidone iodine, iodo-polyalcohol ether form; Described hibitane adds with chlorhexidine acetate, chlorhexidine hydrochloride, citric acid hibitane or chlorhexidine gluconate form.
5. compound iodine disinfectant solution according to claim 4, is characterized in that: described iodine adds fashionable with povidone iodine, described hibitane with chlorhexidine acetate form, and in every 100ml disinfectant solution, povidone iodine is 6g, chlorhexidine acetate is 0.15g.
6. compound iodine disinfectant solution according to claim 1 and 2, is characterized in that: also containing glycerol, PEG-1000 in described solvent; Further, also 1-6g glycerol, 1-6g PEG-1000 is contained in every 100ml disinfectant solution; Preferably, also 3g glycerol, 3g PEG-1000 is contained in every 100ml disinfectant solution.
7. the preparation method of compound iodine disinfectant solution described in claim 6, is characterized in that: it comprises following operating procedure:
(1) iodine is dissolved in part water, obtains solution I;
(2) hibitane, solubilizing agent, PEG-1000 and glycerol are dissolved in part water, obtain solution II;
(3) solution II mixed homogeneously with I, add water standardize solution, to obtain final product.
8. compound iodine disinfectant solution described in claim 1 ~ 6 any one is in the purposes of skin disinfectant for external use of preparation antibacterium or fungus; Further, described antibacterial is escherichia coli, staphylococcus aureus, Salmonella, shigella or bacillus subtilis; Described fungus is Candida albicans.
9. purposes according to claim 8, is characterized in that: described antibacterial is Salmonella or shigella.
10. a sterile products, is characterized in that: it is prepared from by compound iodine disinfectant solution described in claim 1 ~ 6 any one and disinfectant solution carrier combinations; Further, described disinfectant solution carrier is selected from cotton balls, gauze etc.
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| CN201510002882.XA CN104523748A (en) | 2015-01-05 | 2015-01-05 | Compound iodine disinfectant and preparation method and application thereof |
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| CN201510002882.XA CN104523748A (en) | 2015-01-05 | 2015-01-05 | Compound iodine disinfectant and preparation method and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362287A (en) * | 2015-12-17 | 2016-03-02 | 山东省农业科学院畜牧兽医研究所 | Disinfecting shower cream for pigs |
| CN106389466A (en) * | 2016-11-15 | 2017-02-15 | 贵州碘雅医疗器械有限公司 | 98-compound iodine disinfection solution and preparation method thereof |
| CN115844967A (en) * | 2022-09-06 | 2023-03-28 | 贵州碘雅医疗器械有限公司 | Compound iodine disinfectant and preparation method and application thereof |
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| US20050255048A1 (en) * | 2004-05-15 | 2005-11-17 | Collegium Pharmaceutical, Inc. | Sprayable formulations for the treatment of acute inflammatory skin conditions |
| CN102727435A (en) * | 2012-07-06 | 2012-10-17 | 中国人民解放军广州军区武汉总医院 | Aqueous chlorhexidine iodine sterilizing spray and preparation method thereof |
| CN103735568A (en) * | 2013-12-19 | 2014-04-23 | 江西草珊瑚消毒用品有限公司 | Compound guanidine complex iodine skin mucosa disinfectant and preparation method thereof |
| CN103816179A (en) * | 2013-12-09 | 2014-05-28 | 樊建胜 | Disinfecting liquid, medical compound iodine sterile cotton ball prepared from disinfecting liquid, and corresponding preparation method |
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2015
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| US20050255048A1 (en) * | 2004-05-15 | 2005-11-17 | Collegium Pharmaceutical, Inc. | Sprayable formulations for the treatment of acute inflammatory skin conditions |
| CN102727435A (en) * | 2012-07-06 | 2012-10-17 | 中国人民解放军广州军区武汉总医院 | Aqueous chlorhexidine iodine sterilizing spray and preparation method thereof |
| CN103816179A (en) * | 2013-12-09 | 2014-05-28 | 樊建胜 | Disinfecting liquid, medical compound iodine sterile cotton ball prepared from disinfecting liquid, and corresponding preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362287A (en) * | 2015-12-17 | 2016-03-02 | 山东省农业科学院畜牧兽医研究所 | Disinfecting shower cream for pigs |
| CN105362287B (en) * | 2015-12-17 | 2017-12-29 | 山东省农业科学院畜牧兽医研究所 | One boar sterilization bath oil |
| CN106389466A (en) * | 2016-11-15 | 2017-02-15 | 贵州碘雅医疗器械有限公司 | 98-compound iodine disinfection solution and preparation method thereof |
| CN115844967A (en) * | 2022-09-06 | 2023-03-28 | 贵州碘雅医疗器械有限公司 | Compound iodine disinfectant and preparation method and application thereof |
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Application publication date: 20150422 |