CN104605960A - Experimental apparatus for studying cardiovascular morbidity mechanism - Google Patents
Experimental apparatus for studying cardiovascular morbidity mechanism Download PDFInfo
- Publication number
- CN104605960A CN104605960A CN201510087570.3A CN201510087570A CN104605960A CN 104605960 A CN104605960 A CN 104605960A CN 201510087570 A CN201510087570 A CN 201510087570A CN 104605960 A CN104605960 A CN 104605960A
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- smoke
- box
- shaped
- cage
- fume extracting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
Abstract
The invention discloses an experimental apparatus for studying a cardiovascular morbidity mechanism which is used for establishing a model of an ordinary cigarette induced cardiovascular disease of mice and forces the mice to move properly in the apparatus to inhale smoke adequately. The experimental apparatus comprises a lower smoke chamber, a smoke inlet pipe, an air inlet pipe, a diffuser plate, a smoke suction box, a rotating drum and a smoke pumping hood. The smoke inlet pipe penetrates the middle portion of the lower smoke chamber, the air inlet pipe is disposed under the smoke inlet pipe, the diffuser plate is disposed above the lower smoke chamber, the smoke suction box is disposed above the diffuser plate, the rotating drum capable of rotating freely is disposed in the middle of the smoke suction box, an exhaust hood is disposed at the top of the smoke suction box, and a speed-adjustable exhaust fan is disposed at the top of the exhaust hood. The experimental apparatus has the advantages that convenience in use is achieved, smoke concentration is adjustable and uniform in distribution, the mice inhale the smoke adequately, the situation that the mice are crowded to avoid smoking during smoke suction is avoided, excreta produced fall in sand padding at the bottom of the lower smoke chamber, and cleaning of the lower smoke chamber is facilitated.
Description
Technical field
The present invention relates to a kind of medical experiment utensil, particularly a kind of experimental provision studying cardiopulmonary vascular event mechanism, it is mainly used in setting up when common cigarette brings out mouse core pulmonary vascular disease model and uses.
Background technology
Containing a large amount of nicotine, tar, carbon monoxide and soot particulates etc. in the smog that human body sucks, larger toxic action is had to the breathing of human body, circulation and nervous system, the rising of palpitating speed, blood pressure, decreased respiratory function, infringement nervous function can be made, seriously affect health.
Smoking is one of lethal most important risk factor of acute pulmonary embolism, and acute pulmonary embolism is that height is disabled fatal disease, and it and Aortic Plaque break, platelet activation, Coagulation Fibrinolysis functional imbalance cause artery thrombosis closely related.
Smoking is also one of chief reason of pulmonary hypertension formation, and the harmful substance that smoking produces can cause the inflammatory reaction of air flue and pulmonary vasculature.On the one hand, the impaired obstruction of air flue even subsides, and ventilation is obstructed, and blood oxygen pressure declines; On the other hand, harmful substance stimulates inflammatory cell at Pulmonary Vascular surrounding wetting, impaired vascular function, and diastolic function is disorderly.Research shows, reduce at pulmonary function, before hypoxemia is formed just there is reconstruct in the Pulmonary Vascular of smoking patients, the pulmonary artery remodeling of this caused by smoking is holostrome reconstruct, it is different from the pulmonary artery remodeling that simple hypoxia causes, in the patients with pulmonary hypertension of caused by smoking, the pulmonary hypertension that mortality rate causes far above other reason.
The clinical person that sees healthy smoking is a large amount of smoking burst pulmonary hypertension, Case report that acute pulmonary embolism is lethal in a short time.Cause pulmonary hypertension and acute pulmonary embolism to there is no effective preventive measure to smoking at present, but essential measure is smoking cessation.Scientific research shows, and smoking can make non-lethality pulmonary hypertension and the lethal risk of pulmonary infarction increase by 3 times, and its pathophysiological mechanism and smoking cause tremulous pulse Acute thrombosis closely related.Smoking causes thrombotic mechanism probably to comprise: smoking causes platelet activation, and mechanism generates NO with endothelial injury and reduces relevant; Endotheliocyte plasminogen activating factors (tPA) generates minimizing and Plasminogen Activator Inhibitor (PAI-I) generation increase promotes that blood is in hypercoagulability; Atherosclerotic plaque place tissue factor, VCAM-1 generate increase, and mononuclear phagocyte assembles increase; The thromboxane A2 that smoking causes intra platelet free calcium a large amount of, makes platelet adhesion aggregation rate increase; Smoking causes speckle unstable.
In order to study the impact of smoking on human lung, usual is by setting up smoking mice pulmonary hypertension and acute pulmonary embolism model mostly, and change and the vascular endothelial function of inquiring into blood coagulation in blood, fibrinolytic factor before and after smoking mice smoking change, blood vessel change.Want to set up smoking mice pulmonary hypertension and acute pulmonary embolism model, just must use mouse tobacco smoke experimental provision.
The current smoking mice smoking experimental provision used that causes a disease is static smoking apparatus, and in this device, people allow certain density smoke from cigarette by being equipped with the experimental provision of mice, and this device once puts into 6 to 12 mices, the every day of smoking 2 to 4 times at regular time and quantity.After 15 days, dissect mice, carry out the analysis of cardiopulmonary vascular pathological pathological changes.But in this mouse tobacco smoke experimental provision generally used at present, mices are in order to hide sootiness and crowded transfixion together, slow down breathing, Mus hair each other has just become the mask of mices, this directly will affect experimental result, thus strengthen the test period, and the test data diversity of experimental group and matched group is not remarkable, affects result of the test.
Summary of the invention
In order to make up the defect of prior art and diversity that is not enough and raising result of the test, the invention provides a kind of experimental provision studying cardiopulmonary vascular event mechanism.This device forces mices at experimental provision ceaselessly autonomous travel, fully sucks smog, to increase the test data diversity of experimental group and matched group.This device is easy to use, and smokescope is adjustable, and smog is evenly distributed, and mice can be forced in ceaselessly moving to suck smog.
For achieving the above object, the technical solution used in the present invention is as follows: a kind of experimental provision studying cardiopulmonary vascular event mechanism, comprises lower smoke box, smoke-intake pipe, blast pipe, diffuser plate, fume extracting box, rotating cage, the smoking cover be made up of transparent organic glass; Wherein lower smoke box is the rectangular box of a upper opening, through at the middle part of lower smoke box 1 to 5 smoke-intake pipe is housed, same in the below of smoke-intake pipe 1 to 5 blast pipe is housed, one piece of diffuser plate is equipped with in the top of lower smoke box, a fume extracting box is housed above diffuser plate, fume extracting box is the rectangular box of a bottom opening, fume extracting box top is arc, one exhaust opening is shaped with at fume extracting box top, be shaped with a hole of coming in and going out for mice at fume extracting box left lower, hole place is covered with a rubber stopper; A rotating cage that can freely rotate is housed in the middle part of fume extracting box, this rotating cage is made up of major axis and the circular end plate being arranged on major axis two ends and the tubbiness cage net that is contained in periphery, cage net is made up of wire netting, being shaped with one below end plate on the left of rotating cage for what pass in and out mice enters cage mouth, it is corresponding with the position at above-mentioned hole that this enters cage mouth, an enclosure is housed at the top of fume extracting box, the air exhauster of an adjustable speed is housed at the top of enclosure.
Be shaped with a tobacco insert hole for plug-in mounting medicated cigarette at the two ends of smoke-intake pipe respectively, be shaped with 1 to 10 smog spout at the middle part of smoke-intake pipe.
Be shaped with the through fresh air inlet of a radial direction at the two ends of blast pipe respectively, be shaped with 1 to 10 air port at the middle part of blast pipe.
Respectively be equipped with one at the two ends of blast pipe and on adjustable cap, be shaped with for regulating the adjustable cap of intake the wind adjusting hole that a radial direction is through, the position of this wind adjusting hole is corresponding with the fresh air inlet on blast pipe.
The middle part of diffuser plate is shaped with many foursquare apertures, and the effect of diffuser plate is by smog uniformly from lower smoke box diffusing in fume extracting box,
In order to allow mices orderly scattering in rotating cage, in the middle part of cage net, 5 to 11 bulge loops to cage net inner projection are made.
One is equipped with for rotating the circular handwheel of rotating cage at the right-hand member of major axis.
Using method of the present invention is: before using first, first bottom lower smoke box, put one deck for absorbing the excremental sandy soil of mice, the medicated cigarette of lighting is inserted in tobacco insert hole, rotate adjustable cap fresh air inlet to be overlapped with wind adjusting hole make air intake unobstructed, start air exhauster, detect the concentration of air exhauster vapour discharge, if concentration is improper, can by the concentration of the method adjustment smog such as the rotating speed of the quantity of plus-minus medicated cigarette, rotation adjustable cap adjustment intake, adjustment air exhauster, after smokescope is adjusted, make a record, to continue from now on to use.Then one group of mice is put into rotating cage from hole through entering cage mouth, block hole with rubber stopper, with hand propelled handwheel, rotating cage is slowly rotated, at this moment mices are naturally separated by bulge loop, and then mices are just along with the rotation of rotating cage is run in rotating cage.So just can reach and allow mice spread out the object of abundant smoking.
The present invention compared with prior art beneficial effect is: easy to use, smokescope is adjustable, smokescope is evenly distributed, mouse tobacco smoke is abundant, mice does not have the crowded situation hiding smoking in the process of smoking, the Excreta produced drops in the sandy soil bedding and padding bottom lower smoke box, is convenient to clear up lower smoke box.
Accompanying drawing explanation
Fig. 1 is front view of the present invention.
Fig. 2 is left view of the present invention.
Fig. 3 is the axial section of smoke-intake pipe.
Fig. 4 is the axial section of blast pipe.
In figure, 1. lower smoke box, 2. smoke-intake pipe, 21. tobacco insert holes, 22. smog spout, 3. blast pipes, 31. fresh air inlets, 32. air ports, 4. adjustable cap, 41. wind adjusting holes, 5. diffuser plate, 6. fume extracting box, 61. holes, 62. rubber stoppers, 63. exhaust openings, 7. rotating cage, 71. major axis, 72. end plates, 73. cage nets, 74. bulge loops, 75. handwheels, 76. enter cage mouth, 8. enclosure, 9. air exhauster.
Detailed description of the invention
In figure, a kind of experimental provision studying cardiopulmonary vascular event mechanism, comprises lower smoke box 1, smoke-intake pipe 2, blast pipe 3, diffuser plate 5, fume extracting box 6, rotating cage 7, the enclosure 8 be made up of transparent organic glass; Wherein lower smoke box 1 is the rectangular box of a upper opening, through at the middle part of lower smoke box 1 to 5 smoke-intake pipe 2 is housed, same in the below of smoke-intake pipe 21 to 5 blast pipe 3 is housed, one piece of diffuser plate 5 is equipped with in the top of lower smoke box 1, a fume extracting box 6 is housed above diffuser plate 5, fume extracting box 6 is the rectangular box of a bottom opening, fume extracting box 6 top is arc, one exhaust opening 63 is shaped with at fume extracting box 6 top, be shaped with a hole 61 of coming in and going out for mice at fume extracting box 6 left lower, hole 61 place is covered with a rubber stopper 62; A rotating cage that can freely rotate 7 is housed in the middle part of fume extracting box 6, this rotating cage 7 is made up of major axis 71 and the circular end plate 72 being arranged on major axis 7 two ends and the tubbiness cage net 73 that is contained in periphery, cage net 73 is made up of wire netting, being shaped with one below end plate 72 on the left of rotating cage 7 for what pass in and out mice enters cage mouth 76, it is corresponding with the position at above-mentioned hole 61 that this enters cage mouth 76, an enclosure 8 is housed at the top of fume extracting box 6, the air exhauster 9 of an adjustable speed is housed at the top of smoking cover 8.
Be shaped with a tobacco insert hole 21 for plug-in mounting medicated cigarette at the two ends of smoke-intake pipe 2 respectively, be shaped with 1 to 10 smog spout 22 at the middle part of smoke-intake pipe 2.
Be shaped with the fresh air inlet 31 that a radial direction is through at the two ends of blast pipe 3 respectively, be shaped with 1 to 10 air port 32. at the middle part of blast pipe
Respectively be equipped with one at the two ends of blast pipe 3 and on adjustable cap 4, be shaped with for regulating the adjustable cap 4 of intake the wind adjusting hole 41 that a radial direction is through, the position of this wind adjusting hole 41 is corresponding with the fresh air inlet 31 on blast pipe 3.
The middle part of diffuser plate 5 is shaped with many foursquare apertures, and the effect of diffuser plate is uniformly from lower smoke box 1 diffusing in fume extracting box 6 by smog.
In order to allow mices orderly scattering in rotating cage, in the middle part of cage net 73,5 to 11 bulge loops 74 to cage net 73 inner projection are made.
One is equipped with for rotating the circular handwheel 75 of rotating cage 7 at the right-hand member of major axis 71.
Claims (7)
1. study an experimental provision for cardiopulmonary vascular event mechanism, it is characterized in that: comprise lower smoke box, smoke-intake pipe, blast pipe, diffuser plate, fume extracting box, rotating cage, smoking cover; Wherein lower smoke box is the rectangular box of a upper opening, through at the middle part of lower smoke box 1 to 5 smoke-intake pipe is housed, same in the below of smoke-intake pipe 1 to 5 blast pipe is housed, one piece of diffuser plate is equipped with in the top of lower smoke box, a fume extracting box is housed above diffuser plate, fume extracting box is the rectangular box of a bottom opening, fume extracting box top is arc, one exhaust opening is shaped with at fume extracting box top, be shaped with a hole of coming in and going out for mice at fume extracting box left lower, hole place is covered with a rubber stopper; A rotating cage that can freely rotate is housed in the middle part of fume extracting box, this rotating cage is made up of major axis and the circular end plate being arranged on major axis two ends and the tubbiness cage net that is contained in periphery, being shaped with one below end plate on the left of rotating cage for what pass in and out mice enters cage mouth, it is corresponding with the position at above-mentioned hole that this enters cage mouth, an enclosure is housed at the top of fume extracting box, the air exhauster of an adjustable speed is housed at the top of enclosure.
2. a kind of experimental provision studying cardiopulmonary vascular event mechanism according to claim 1, is characterized in that: the two ends of described smoke-intake pipe are shaped with a tobacco insert hole for plug-in mounting medicated cigarette respectively, are shaped with 1 to 10 smog spout at the middle part of smoke-intake pipe.
3. a kind of experimental provision studying cardiopulmonary vascular event mechanism according to claim 1, is characterized in that: the two ends of described blast pipe are shaped with the through fresh air inlet of a radial direction respectively, are shaped with 1 to 10 air port at the middle part of blast pipe.
4. a kind of experimental provision studying cardiopulmonary vascular event mechanism according to claim 1, it is characterized in that: the two ends of described blast pipe are respectively equipped with one for regulating the adjustable cap of intake, adjustable cap is shaped with the wind adjusting hole that a radial direction is through, and the position of this wind adjusting hole is corresponding with the fresh air inlet on blast pipe.
5. a kind of experimental provision studying cardiopulmonary vascular event mechanism according to claim 1, is characterized in that: the middle part of described diffuser plate is shaped with many foursquare apertures.
6. a kind of experimental provision studying cardiopulmonary vascular event mechanism according to claim 1, is characterized in that: made 5 to 11 bulge loops to cage net inner projection in the middle part of described cage net.
7. a kind of experimental provision studying cardiopulmonary vascular event mechanism according to claim 1, is characterized in that: the right-hand member of described major axis is equipped with one for rotating the circular handwheel of rotating cage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510087570.3A CN104605960B (en) | 2015-02-26 | 2015-02-26 | A kind of experimental provision studying cardiopulmonary vascular event mechanism |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510087570.3A CN104605960B (en) | 2015-02-26 | 2015-02-26 | A kind of experimental provision studying cardiopulmonary vascular event mechanism |
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| CN104605960A true CN104605960A (en) | 2015-05-13 |
| CN104605960B CN104605960B (en) | 2016-08-17 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476728A (en) * | 2016-02-15 | 2016-04-13 | 赵菁 | Experiment device for inducing mouse cardiopulmonary vascular diseases |
| CN106725992A (en) * | 2016-12-27 | 2017-05-31 | 山西医科大学 | A kind of passive smoking device for preparing COPD animal model |
| CN107280804A (en) * | 2016-04-13 | 2017-10-24 | 北京元和基因科技有限公司 | It is a kind of to study the experimental rig that smoking influence on angiocardiopathy generation |
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| US4810510A (en) * | 1986-07-08 | 1989-03-07 | Agfa-Gevaert N.V. | Method of smoking food |
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| CN105476728A (en) * | 2016-02-15 | 2016-04-13 | 赵菁 | Experiment device for inducing mouse cardiopulmonary vascular diseases |
| CN107280804A (en) * | 2016-04-13 | 2017-10-24 | 北京元和基因科技有限公司 | It is a kind of to study the experimental rig that smoking influence on angiocardiopathy generation |
| CN106725992A (en) * | 2016-12-27 | 2017-05-31 | 山西医科大学 | A kind of passive smoking device for preparing COPD animal model |
| CN106725992B (en) * | 2016-12-27 | 2018-05-18 | 山西医科大学 | A kind of passive smoking device for being used to prepare Chronic Obstructive Pulmonary Disease animal model |
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| Publication number | Publication date |
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| CN104605960B (en) | 2016-08-17 |
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Inventor after: Zhao Jing Inventor after: Xie Wenbo Inventor after: Han Quancheng Inventor after: Cheng Jiayue Inventor after: Qiao Bo Inventor after: Xie Yingying Inventor after: Zhao Zuan Inventor after: Gou Jianjun Inventor after: Pei Pinheng Inventor after: Li Aijuan Inventor before: Zhao Jing |
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Effective date of registration: 20160622 Address after: 450052 Henan Province, Zhengzhou City, No. 27 East Road, building No. 1 Applicant after: The First Affiliated Hospital of Zhengzhou University Address before: 450052 Henan City, Zhengzhou province No. 27 Central Plains Road, building No. 78, building No. 18, No. 43 Applicant before: Zhao Jing |
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