CN104605960B - A kind of experimental provision studying cardiopulmonary vascular event mechanism - Google Patents
A kind of experimental provision studying cardiopulmonary vascular event mechanism Download PDFInfo
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- CN104605960B CN104605960B CN201510087570.3A CN201510087570A CN104605960B CN 104605960 B CN104605960 B CN 104605960B CN 201510087570 A CN201510087570 A CN 201510087570A CN 104605960 B CN104605960 B CN 104605960B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
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Abstract
A kind of experimental provision studying cardiopulmonary vascular event mechanism, is used for when setting up common cigarette induction mouse core pulmonary vascular disease model using.This device can force mices autonomous travel in experimental provision, fully sucks smog.It includes lower smoke box, smoke-intake pipe, blast pipe, diffuser plate, fume extracting box, rotating cage, enclosure；Wherein through equipped with smoke-intake pipe at the middle part of lower smoke box, equipped with blast pipe under smoke-intake pipe, the top of lower smoke box is equipped with one piece of diffuser plate, equipped with a fume extracting box above diffuser plate, in the middle part of fume extracting box equipped with one can be freely rotatable rotating cage, at the top of fume extracting box equipped with an enclosure, at the top of enclosure equipped with the air exhauster of an adjustable speed.The invention has the beneficial effects as follows: easy to use, smokescope is adjustable, and smokescope is evenly distributed, mouse tobacco smoke is abundant, mice does not has the crowded situation hiding smoking during smoking, and produced Excreta falls in the sandy soil bedding and padding bottom lower smoke box, it is simple to cleaning lower smoke box.
Description
Technical field
The present invention relates to a kind of medical experiment utensil, particularly to a kind of experimental provision studying cardiopulmonary vascular event mechanism, it is mainly used in when setting up common cigarette induction mouse core pulmonary vascular disease model using.
Background technology
Containing a large amount of nicotine, tar, carbon monoxide and soot particulates etc. in the smog that human body sucks, breathing, circulation and the nervous system of human body there is bigger toxic action, the rising of palpitating speed, blood pressure, decreased respiratory function, infringement nervous function can be made, severely impact health.
Smoking is one of lethal most important risk factor of acute pulmonary embolism, and acute pulmonary embolism is that height is disabled fatal disease, and it ruptures with Aortic Plaque, platelet activation, Coagulation Fibrinolysis functional imbalance cause artery thrombosis closely related.
Smoking is also one of chief reason of pulmonary hypertension formation, and the harmful substance that smoking produces can cause the inflammatory reaction of air flue and pulmonary vasculature.On the one hand, the impaired obstruction of air flue even subsides, and ventilation is obstructed, and blood oxygen pressure declines；On the other hand, harmful substance stimulates inflammatory cell at Pulmonary Vascular surrounding wetting, impaired vascular function, and diastolic function is disorderly.Research shows, reduce at pulmonary function, before hypoxemia formation, the Pulmonary Vascular of smoking patients has occurred in that reconstruct, the pulmonary artery remodeling of this caused by smoking is holostrome reconstruct, the pulmonary artery remodeling that it causes from simple hypoxia is different, in the patients with pulmonary hypertension of caused by smoking, the pulmonary hypertension that mortality rate causes far above other reason.
Clinical visible healthy smoking person a large amount of smoking burst pulmonary hypertensions in a short time, the Case report that acute pulmonary embolism is lethal.Smoking causes pulmonary hypertension and acute pulmonary embolism there is no effective preventive measure at present, but essential measure is smoking cessation.Scientific research shows, smoking can make non-lethality pulmonary hypertension and the lethal risk of pulmonary infarction increase by 3 times, and its pathophysiological mechanism and smoking cause tremulous pulse Acute thrombosis closely related.Smoking causes thrombotic mechanism probably to include: smoking causes platelet activation, and it is relevant that mechanism generates NO minimizing with endothelial injury；Endotheliocyte plasminogen activating factors (tPA) generates to reduce to generate with Plasminogen Activator Inhibitor (PAI-I) to increase and promotes that blood is in hypercoagulability；At atherosclerotic plaque, tissue factor, VCAM-1 generate increase, and mononuclear phagocyte assembles increase；Smoking causes the substantial amounts of thromboxane A2 of intra platelet free calcium, makes platelet adhesion aggregation rate increase；Smoking causes speckle unstable.
In order to study the smoking impact on human lung, it is generally by setting up smoking mice pulmonary hypertension and acute pulmonary embolism model mostly, blood coagulation in blood before and after discussion smoking mice smoking, the change of fibrinolytic factor and vascular endothelial function change, blood vessel change.Want to set up smoking mice pulmonary hypertension and acute pulmonary embolism model, be necessary for mouse tobacco smoke experimental provision to be used.
At present the smoking mice smoking experimental provision used that causes a disease is static smoking apparatus, and in this device, people allow certain density smoke from cigarette once put into 6 to 12 mices by the experimental provision equipped with mice, this device, the every day of smoking 2 to 4 times at regular time and quantity.After 15 days, dissect mice, carry out cardiopulmonary vascular pathological pathological changes analysis.But in this mouse tobacco smoke experimental provision commonly used at present, mices are in order to hide sootiness and crowded transfixion together, slow down breathing, Mus hair each other has just become the mask of mices, this will directly affect experimental result, thus strengthen the test period, and experimental group is not notable with the test data diversity of matched group, affects result of the test.
Summary of the invention
In order to make up the defect of prior art and the not enough and diversity of raising result of the test, the present invention provides a kind of experimental provision studying cardiopulmonary vascular event mechanism.This device forces mices at experimental provision ceaselessly autonomous travel, fully sucks smog, in order to increase the test data diversity of experimental group and matched group.This device is easy to use, and smokescope is adjustable, and smog is evenly distributed, and mice can be forced to suck smog in ceaselessly motion.
For achieving the above object, the technical solution used in the present invention is as follows: a kind of experimental provision studying cardiopulmonary vascular event mechanism, including the lower smoke box being made up of transparent organic glass, smoke-intake pipe, blast pipe, diffuser plate, fume extracting box, rotating cage, enclosure；Wherein lower smoke box is the rectangular box of a upper opening, through equipped with 1 to 5 smoke-intake pipe at the middle part of lower smoke box, same equipped with 1 to 5 blast pipe in the lower section of smoke-intake pipe, the top of lower smoke box is equipped with one piece of diffuser plate, equipped with a fume extracting box above diffuser plate, fume extracting box is the rectangular box of a bottom opening, fume extracting box top is arc, it is shaped with one exhaust opening at fume extracting box top, fume extracting box left lower be shaped with one for mice come in and go out hole, be covered with a rubber stopper at hole；In the middle part of fume extracting box equipped with one can be freely rotatable rotating cage, circular end plate that this rotating cage by major axis and is arranged on major axis two ends and be contained in the tubbiness cage net of periphery and constitute, cage net is made up of wire netting, it is shaped with one below end plate on the left of rotating cage and enters cage mouth for pass in and out mice, it is corresponding with the position at above-mentioned hole that this enters cage mouth, at the top of fume extracting box equipped with an enclosure, at the top of enclosure equipped with the air exhauster of an adjustable speed.
It is formed respectively with a tobacco insert hole for plug-in mounting medicated cigarette at the two ends of smoke-intake pipe, is shaped with 1 to 10 smog spout at the middle part of smoke-intake pipe.
It is formed respectively with a through fresh air inlet of radial direction at the two ends of blast pipe, is shaped with 1 to 10 air port at the middle part of blast pipe.
At the two ends of blast pipe respectively equipped with an adjustable cap being used for regulating intake, being shaped with a through wind adjusting hole of radial direction on adjustable cap, the position of this wind adjusting hole is corresponding with the fresh air inlet on blast pipe.
The middle part of diffuser plate is shaped with many foursquare apertures, the effect of diffuser plate be by smog uniformly from lower smoke box diffusing to fume extracting box in,
In order to allow mices orderly scattering in rotating cage, in the middle part of cage net, 5 to 11 bulge loops to cage net inner projection are made.
At the right-hand member of major axis equipped with one for rotating the circular handwheel of rotating cage.
The using method of the present invention is: before using first, first bottom lower smoke box, put one layer for absorbing the excremental sandy soil of mice, the medicated cigarette lighted is inserted in tobacco insert hole, rotate adjustable cap to make fresh air inlet overlap with wind adjusting hole to make air intake unobstructed, start air exhauster, the concentration of detection air exhauster vapour discharge, if concentration is improper, the concentration of smog can be adjusted by methods such as the quantity of plus-minus medicated cigarette, the rotating speeds rotating adjustable cap adjustment intake, adjustment air exhauster, after smokescope is adjusted, make a record, in order to be continuing with from now on.Then one group of mice being put into rotating cage from hole through entering cage mouth, block hole with rubber stopper, make rotating cage slowly rotate with hand propelled handwheel, at this moment mices are naturally separated by bulge loop, and then mices are just run in rotating cage along with the rotation of rotating cage.Thus can reach to allow mice spread out the purpose of abundant smoking.
The present invention compared with prior art provides the benefit that: easy to use, smokescope is adjustable, smokescope is evenly distributed, mouse tobacco smoke is abundant, mice does not has the crowded situation hiding smoking during smoking, produced Excreta falls in the sandy soil bedding and padding bottom lower smoke box, it is simple to cleaning lower smoke box.
Accompanying drawing explanation
Fig. 1 is the front view of the present invention.
Fig. 2 is the left view of the present invention.
Fig. 3 is the axial section of smoke-intake pipe.
Fig. 4 is the axial section of blast pipe.
In figure, 1. lower smoke box, 2. smoke-intake pipe, 21. tobacco insert holes, 22. smog spout, 3. blast pipes, 31. fresh air inlets, 32. air ports, 4. adjustable cap, 41. wind adjusting holes, 5. diffuser plate, 6. fume extracting box, 61. holes, 62. rubber stoppers, 63. exhaust openings, 7. rotating cage, 71. major axis, 72. end plates, 73. cage nets, 74. bulge loops, 75. handwheels, 76. enter cage mouth, 8. enclosure, 9. air exhauster.
Detailed description of the invention
In figure, a kind of experimental provision studying cardiopulmonary vascular event mechanism, including the lower smoke box 1 being made up of transparent organic glass, smoke-intake pipe 2, blast pipe 3, diffuser plate 5, fume extracting box 6, rotating cage 7, enclosure 8；Wherein lower smoke box 1 is the rectangular box of a upper opening, through equipped with 1 to 5 smoke-intake pipe 2 at the middle part of lower smoke box, same equipped with 1 to 5 blast pipe 3 in the lower section of smoke-intake pipe 2, the top of lower smoke box 1 is equipped with one piece of diffuser plate 5, equipped with a fume extracting box 6 above diffuser plate 5, fume extracting box 6 is the rectangular box of a bottom opening, fume extracting box 6 top is arc, it is shaped with one exhaust opening 63 at fume extracting box 6 top, fume extracting box 6 left lower be shaped with one for mice come in and go out hole 61, be covered with a rubber stopper 62 at hole 61；In the middle part of fume extracting box 6 equipped with one can be freely rotatable rotating cage 7, circular end plate 72 that this rotating cage 7 by major axis 71 and is arranged on major axis 7 two ends and the tubbiness cage net 73 being contained in periphery are constituted, cage net 73 is made up of wire netting, it is shaped with one below end plate 72 on the left of rotating cage 7 and enters cage mouth 76 for pass in and out mice, it is corresponding with the position at above-mentioned hole 61 that this enters cage mouth 76, at the top of fume extracting box 6 equipped with an enclosure 8, at the top of enclosure 8 equipped with the air exhauster 9 of an adjustable speed.
It is formed respectively with a tobacco insert hole 21 for plug-in mounting medicated cigarette at the two ends of smoke-intake pipe 2, is shaped with 1 to 10 smog spout 22 at the middle part of smoke-intake pipe 2.
It is formed respectively with a through fresh air inlet of radial direction 31 at the two ends of blast pipe 3, is shaped with 1 to 10 air port 32. at the middle part of blast pipe
At the two ends of blast pipe 3 respectively equipped with an adjustable cap 4 being used for regulating intake, being shaped with a through wind adjusting hole of radial direction 41 on adjustable cap 4, the position of this wind adjusting hole 41 is corresponding with the fresh air inlet 31 on blast pipe 3.
The middle part of diffuser plate 5 is shaped with many foursquare apertures, the effect of diffuser plate be by smog uniformly in lower smoke box 1 diffusing to fume extracting box 6.
In order to allow mices orderly scattering in rotating cage, in the middle part of cage net 73,5 to 11 bulge loops 74 to cage net 73 inner projection are made.
At the right-hand member of major axis 71 equipped with one for rotating the circular handwheel 75 of rotating cage 7.
Claims (7)
1. study an experimental provision for cardiopulmonary vascular event mechanism, it is characterized in that: include lower smoke box, smoke-intake pipe, blast pipe, diffuser plate, fume extracting box, rotating cage, enclosure；Wherein lower smoke box is the rectangular box of a upper opening, through equipped with 1 to 5 smoke-intake pipe at the middle part of lower smoke box, same equipped with 1 to 5 blast pipe in the lower section of smoke-intake pipe, the top of lower smoke box is equipped with one piece of diffuser plate, equipped with a fume extracting box above diffuser plate, fume extracting box is the rectangular box of a bottom opening, fume extracting box top is arc, it is shaped with one exhaust opening at fume extracting box top, fume extracting box left lower be shaped with one for mice come in and go out hole, be covered with a rubber stopper at hole；In the middle part of fume extracting box equipped with one can be freely rotatable rotating cage, circular end plate that this rotating cage by major axis and is arranged on major axis two ends and be contained in the tubbiness cage net of periphery and constitute, it is shaped with one below end plate on the left of rotating cage and enters cage mouth for pass in and out mice, it is corresponding with the position at above-mentioned hole that this enters cage mouth, at the top of fume extracting box equipped with an enclosure, at the top of enclosure equipped with the air exhauster of an adjustable speed.
A kind of experimental provision studying cardiopulmonary vascular event mechanism the most according to claim 1, is characterized in that: the two ends of described smoke-intake pipe are formed respectively with a tobacco insert hole for plug-in mounting medicated cigarette, is shaped with 1 to 10 smog spout at the middle part of smoke-intake pipe.
A kind of experimental provision studying cardiopulmonary vascular event mechanism the most according to claim 1, is characterized in that: the two ends of described blast pipe are formed respectively with a through fresh air inlet of radial direction, are shaped with 1 to 10 air port at the middle part of blast pipe.
A kind of experimental provision studying cardiopulmonary vascular event mechanism the most according to claim 1, it is characterized in that: the two ends of described blast pipe are respectively equipped with an adjustable cap being used for regulating intake, being shaped with a through wind adjusting hole of radial direction on adjustable cap, the position of this wind adjusting hole is corresponding with the fresh air inlet on blast pipe.
A kind of experimental provision studying cardiopulmonary vascular event mechanism the most according to claim 1, is characterized in that: the middle part of described diffuser plate is shaped with many foursquare apertures.
A kind of experimental provision studying cardiopulmonary vascular event mechanism the most according to claim 1, is characterized in that: made 5 to 11 bulge loops to cage net inner projection in the middle part of described cage net.
A kind of experimental provision studying cardiopulmonary vascular event mechanism the most according to claim 1, is characterized in that: the right-hand member of described major axis is equipped with a circular handwheel being used for rotating rotating cage.
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| CN201510087570.3A CN104605960B (en) | 2015-02-26 | 2015-02-26 | A kind of experimental provision studying cardiopulmonary vascular event mechanism |
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| CN201510087570.3A CN104605960B (en) | 2015-02-26 | 2015-02-26 | A kind of experimental provision studying cardiopulmonary vascular event mechanism |
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| CN104605960B true CN104605960B (en) | 2016-08-17 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476728A (en) * | 2016-02-15 | 2016-04-13 | 赵菁 | Experiment device for inducing mouse cardiopulmonary vascular diseases |
| CN107280804A (en) * | 2016-04-13 | 2017-10-24 | 北京元和基因科技有限公司 | It is a kind of to study the experimental rig that smoking influence on angiocardiopathy generation |
| CN106725992B (en) * | 2016-12-27 | 2018-05-18 | 山西医科大学 | A kind of passive smoking device for being used to prepare Chronic Obstructive Pulmonary Disease animal model |
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| US4216741A (en) * | 1979-03-05 | 1980-08-12 | Hazleton Systems, Inc. | Exposure chamber |
| US4810510A (en) * | 1986-07-08 | 1989-03-07 | Agfa-Gevaert N.V. | Method of smoking food |
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Inventor after: Zhao Jing Inventor after: Xie Wenbo Inventor after: Han Quancheng Inventor after: Cheng Jiayue Inventor after: Qiao Bo Inventor after: Xie Yingying Inventor after: Zhao Zuan Inventor after: Gou Jianjun Inventor after: Pei Pinheng Inventor after: Li Aijuan Inventor before: Zhao Jing |
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