CN104610149A - 一种茚并吡唑类小分子微管蛋白抑制剂及其制备方法与应用 - Google Patents

一种茚并吡唑类小分子微管蛋白抑制剂及其制备方法与应用 Download PDF

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Publication number
CN104610149A
CN104610149A CN201510070144.9A CN201510070144A CN104610149A CN 104610149 A CN104610149 A CN 104610149A CN 201510070144 A CN201510070144 A CN 201510070144A CN 104610149 A CN104610149 A CN 104610149A
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China
Prior art keywords
oxyethyl group
pyrazoles
indeno
methyl
ethoxyl phenenyl
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CN201510070144.9A
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Chinese (zh)
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CN104610149B (zh
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刘兆鹏
刘晏娜
史艳秋
张成梅
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Ji'nan Makall Biological Medicine Technology Co Ltd
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Shandong University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
CN201510070144.9A 2015-02-10 2015-02-10 一种茚并吡唑类小分子微管蛋白抑制剂及其制备方法与应用 Active CN104610149B (zh)

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CN201510070144.9A CN104610149B (zh) 2015-02-10 2015-02-10 一种茚并吡唑类小分子微管蛋白抑制剂及其制备方法与应用

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CN104610149A true CN104610149A (zh) 2015-05-13
CN104610149B CN104610149B (zh) 2017-04-05

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111393368A (zh) * 2020-05-19 2020-07-10 山东大学 一种茚并吡唑盐酸盐类衍生物及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1368970A (zh) * 1999-04-06 2002-09-11 克诺尔股份有限公司 作为酪氨酸激酶抑制剂的取代的1,4－二氢茚并[1,2－c]吡唑
CN1914179A (zh) * 2003-11-13 2007-02-14 詹森药业有限公司 用于生物分子靶标识别的固定的n－取代的三环3－氨基吡唑类
WO2008094896A1 (en) * 2007-01-31 2008-08-07 Janssen Pharmaceutica, N.V. N-substituted tricyclic 3-aminopyrazoles as anti-mitotic tubulin polymerization inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1368970A (zh) * 1999-04-06 2002-09-11 克诺尔股份有限公司 作为酪氨酸激酶抑制剂的取代的1,4－二氢茚并[1,2－c]吡唑
CN1914179A (zh) * 2003-11-13 2007-02-14 詹森药业有限公司 用于生物分子靶标识别的固定的n－取代的三环3－氨基吡唑类
WO2008094896A1 (en) * 2007-01-31 2008-08-07 Janssen Pharmaceutica, N.V. N-substituted tricyclic 3-aminopyrazoles as anti-mitotic tubulin polymerization inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHIH Y. HO等: "(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
HIDEMITSU MINEGISHI等: "Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)‑1 Inhibitors", 《ACS MEDICINAL CHEMISTRY LETTERS》 *
刘翎，等: "作用于秋水仙碱结合位点的微管蛋白抑制剂药效团的构建", 《中国新药杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111393368A (zh) * 2020-05-19 2020-07-10 山东大学 一种茚并吡唑盐酸盐类衍生物及其制备方法与应用

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Address after: 250000 the southern section of Shun Hing Road, Ji'nan chemical industry park, north of 308 National Road, Tianqiao District, Ji'nan, Shandong.

Patentee after: Ji'nan makall Biological Medicine Technology Co Ltd

Address before: 250061 culture West Road, Lishi District, Ji'nan, Shandong Province, No. 44

Patentee before: Shandong University