CN104645408A - Method for preparing gradient beta phase tricalcium phosphate bone substitute material - Google Patents
Method for preparing gradient beta phase tricalcium phosphate bone substitute material Download PDFInfo
- Publication number
- CN104645408A CN104645408A CN201510101803.0A CN201510101803A CN104645408A CN 104645408 A CN104645408 A CN 104645408A CN 201510101803 A CN201510101803 A CN 201510101803A CN 104645408 A CN104645408 A CN 104645408A
- Authority
- CN
- China
- Prior art keywords
- blank
- gradient
- tricalcium phosphate
- sintering
- successively
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a method for preparing a gradient beta phase tricalcium phosphate bone substitute material. The method comprises the following steps: pressing beta phase tricalcium phosphate, an adhesive, a pore-forming-gas producing agent and a surfactant blank layer by layer; performing surface activation treatment by adopting a surfactant, and performing layer-by-layer assembling and compound sintering, thereby obtaining the gradient beta phase tricalcium phosphate bone substitute material, wherein the adhesive refers to polyvinyl alcohol powder with the granularity of 120-200 meshes; the pore-forming-gas producing agent refers to stearic acid; and the surfactant refers to titanium dioxide suspension. The bone substitute material prepared by the method disclosed by the invention has high biocompatibility and interfacial biological activity and can be applied to research and application of bionic bone materials. According to the structural design of the bone substitute material, the outer dense and inner sparse structure of the human skeleton, namely a gradient distribution structure of which the porosity is increased from interior to interior layer to layer, is imitated according to the bionics principle, the channel and space are provided for growth of fibrocyte and bone cells in the material, the bonding area of new bones and the material is increased, and the mechanical property of the material is good and is close to that of human bones.
Description
Technical field
The present invention relates to a kind of preparation method of gradient β phase tricalcium phosphate bone alternate material.
Background technology
The ingredient that skeleton is wanted as body weight for humans, it plays irreplaceable protection and supporting function to each internal organs of human body, and be also responsible for functions such as supporting trunk, hemopoietic, storage calcium, metabolism, be the basis of human life simultaneously.Skeletal injury can cause great infringement to human body, and most of Cranial defect can not spontaneous recovery, needs to carry out bone alternate material transplantation treatment.The bone alternate material that can be used for bone collection treatment is varied, generally comprises metal material, nonmetallic materials and macromolecular material etc., and often kind of material can also continue classification according to its character and feature.β phase tricalcium phosphate-based its composition of bioceramic material in current nonmetallic materials and the inorganic phase composition in sclerotin quite similar, its degradability, the compatibility and in induction of bone growth, have special advantage, the application therefore in bone alternate material is very extensive.
Nature bone is made up of the hone lamella of concentric arrays and havers' system, outer fine and close, hard, thick, is cortical bone, and internal layer arrangement is loosened, and in cellular, is spongy bone.According to biological nature requirement, gradient β phase tricalcium phosphate bone alternate material should have controllable heterogeneous body many microporous connectivity structure and structure gradient and distribution of material gradient.Porous gradient-structure increases the contact area between material and tissue fluid, accelerates course of dissolution, and the depressed area of stomatal limiting value is conducive to Local C a
2+, PO
4 -3ion supersaturation, thus the deposition accelerating β phase tricalcium phosphate, be conducive to synostosis.In addition, porous gradient-structure is fibrocyte, osteocyte grows and provides channel and space in material, adds the bonded area of new bone and material.Current porous gradient bioceramic material preparation method mainly adopts slip casting method and Polymeric sponge method.Slip casting method adopts Gypsum Fibrosum as slip casting mould usually, and gypsum mold very easily damages in dry and slip casting process, thus enters blank and cause pollution, has an impact to material porosity and performance; Polymeric sponge method foam impregnation ceramic size, burns organic foam after drying, and this method causes material hole wall defect more, and stress is concentrated comparatively serious, thus causes mechanical property poor.The present invention puts the surperficial crushing resistance being both to ensure that Archaeological iron unlike the prior art, in turn ensure that the Biofunctional of Archaeological iron, is a kind of high efficiency method prepared compared with long bone substitution material.
Summary of the invention
The object of this invention is to provide a kind of preparation method of gradient β phase tricalcium phosphate bone alternate material, solve current material, the problem that comprcssive strength is little, Biofunctional is poor of gradient bone alternate material prepared by technology, efficiently can prepare the longer bone alternate material of longitudinal size.
The present invention is by β phase tricalcium phosphate, binding agent, pore-gas generating agent and surfactant blank through successively suppressing, and adopt surfactant to carry out surface activation process, successively assembling is with complex sintered, obtained gradient β phase tricalcium phosphate bone alternate material.
Described binding agent is 120 order ~ 200 object pva powders.
Described pore-gas generating agent is stearic acid.
Described surfactant is titanium dioxide suspension.
Concrete steps of the present invention are:
First the β phase tricalcium phosphate of mass percent 60% ~ 80% and the binding agent of mass percent 20% ~ 40% are mixed, add pore-gas generating agent wherein afterwards, in raw material, the content ecto-entad of pore-gas generating agent successively increases progressively, and pore-gas generating agent addition mark is m
n, n=1,2,3,4 ... .., 4≤n≤12, it is as follows that pore-gas generating agent addition increases progressively formula: m
n=m
1(1-5%)
n, the relation formula that increases progressively of number of apertures N and space average diameter γ is N=A γ
b, A is wherein proportionality coefficient, and B is the number of plies of distribution of pores; Roller batch mixer is adopted to mix afterwards, mixing rotating speed 30r/min≤v
1≤ 60r/min, incorporation time 20min≤t
1≤ 30min;
Prepare n group batch mixing altogether, 4≤n≤12, are labeled as T from inside to outside successively
1, T
2..., T
n-1, T
n;
The preparation method of gradient-structure comprises the steps:
1. successively blank is suppressed: adopt stainless steel mould, molding die mark is M
n, n=1,2,3,4 ... .., 4≤n≤12, wherein molding die M
nouter radius be greater than molding die M
n-1outer radius, raw material is successively inwardly suppressed from outermost layer according to correspondence order, compacting pressure be P
1, 60MPa≤P
1≤ 200MPa, compacting is divided into four-stage, and per dwell time in stage is respectively t
1, t
2, t
3, t
4, 15s≤t
1, t
2, t
3≤ 120s, 600s≤t
4≤ 800s, deflation time is respectively t
' 1, t
' 2, t
' 3, 15s≤t
' 1, t
' 2, t
' 3≤ 150s;
It is F that mold pressing obtains blank mark
n, n=1,2,3,4 ... .., 4≤n≤12, blank interface is semicircular arc, and external diameter is R
no, internal diameter is R
ni, n=2,3,4 ... .., 4≤n≤12, and adjacent two blank internal-and external diameters meet R
no=R
(n+1) i+ θ, 0.00mm≤θ≤0.02mm, core blank interface is semicircle, and radius is R
1, R
1=R
2i+ θ, above mold process repeats two cycles, and mold pressing second round obtains blank F'
n, n=1,2,3,4 ... .., 4≤n≤12, obtain blank F with period 1 mold pressing
nidentical;
2. surface activation process: adopt titanium dioxide suspension even application in blank inner surface, after dry, coating layer thickness is h
1, h
1=k θ, 0.6≤k≤1.2;
3. successively assemble: above-mentioned mold pressing is obtained blank F
nwith F'
nsuccessively outwards carry out splicing assembling according to correspondence order from innermost layer, the corner between adjacent two layers blank splicing seams is α, α=30 °, clockwise, obtains n layer blank F
nwith F'
nthe cylindrical coaxial complex blank F assembled, length is L
f, 5cm≤L
f≤ 60cm, radius is R
f, R
f=R
no+ (2n-2) θ, leaves standstill 30min; Insert in sintering mold S by cylindrical coaxial complex blank F, sintering mold S is the hollow cylinder that stainless steel material makes, and length is Ls, Ls>=L
f, inside radius is R
si, R
si=R
f+ k θ, 0.8≤k≤1.5;
4. complex sintered: to adopt gradient temperature repeatedly to sinter gradient porous coaxial complex blank F;
The sintering first stage, sintering temperature T
1, T
1be 1 ~ 200 DEG C, heat time heating time t
a1, t
a1for 63min, temperature retention time t
b1, t
b1for 30min;
Sintering second stage, sintering temperature T
2, T
2be 200 ~ 250 DEG C, heat time heating time t
a2, t
a2for 25min, temperature retention time t
b2, t
b2for 30min;
The sintering phase III, sintering temperature is T
3, T
3be 250 ~ 380 DEG C, heat time heating time t
a3, t
a3for 65min, temperature retention time t
b3, t
b3for 30min;
Sintering fourth stage, sintering temperature is T
4, T
4be 380 ~ 1000 DEG C, heat time heating time t
a4, t
a4for 207min, temperature retention time t
b4, t
b4for 5h, furnace cooling, obtains a kind of gradient β phase tricalcium phosphate bone alternate material.
Beneficial effect of the present invention:
Obtained gradient β phase tricalcium phosphate bone alternate material is a kind of bioactive β phase tricalcium phosphate-based bioceramic material, and it is having good application in the Orthopedic Clinical treatments such as osseous tissue disappearance reparation, tissue reconstruction, bone disease treatment.And simulate porous " the interior thin outer close " gradient-structure of nature bone concentric arrays hone lamella structure and imitated osseous tissue, internal structure hole rate is high, be conducive to obtaining skeletal growth factor such as absorption bone morphogenetic protein(BMP) or marrow stromal cell etc., and reasonably mate the concentration of skeletal growth factor in complex; Layer structure porosity is low, and mechanical property is good, and compressive property is high; Efficiently can prepare the longer bone alternate material of longitudinal size by this method, avoid blank in pressing process to be stressed uneven impact; Adopt surface activation process every layer blank inner surface, strengthen the associativity between every layer of blank; Adopt successively corner splicing assembling blank method, effectively avoid the problems such as splicing seams place stress is concentrated, mechanical property is unstable; Finally, the present invention adopts repeatedly gradient temperature to sinter, and makes blank produce granule under suitable temperature environment and coheres, and produces intensity and causes densification and recrystallize, becoming a kind of gradient β phase tricalcium phosphate bone alternate material of high-quality.
Accompanying drawing explanation
Fig. 1 is flow chart of the present invention.
Fig. 2 is the cross section sectional view of four layers of gradient β phase tricalcium phosphate bone alternate material that the present invention obtains.
Detailed description of the invention
The present invention is by β phase tricalcium phosphate, binding agent, pore-gas generating agent and surfactant blank through successively suppressing, and adopt surfactant to carry out surface activation process, successively assembling is with complex sintered, obtained gradient β phase tricalcium phosphate bone alternate material.
As shown in Figure 1, concrete steps of the present invention are:
First the β phase tricalcium phosphate of mass percent 60% ~ 80% and the binding agent of mass percent 20% ~ 40% are mixed, add pore-gas generating agent wherein afterwards, in raw material, the content ecto-entad of pore-gas generating agent successively increases progressively, and pore-gas generating agent addition mark is m
n, n=1,2,3,4 ... .., 4≤n≤12, it is as follows that pore-gas generating agent addition increases progressively formula: m
n=m
1(1-5%)
n, the relation formula that increases progressively of number of apertures N and space average diameter γ is N=A γ
b, A is wherein proportionality coefficient, and B is the number of plies of distribution of pores; Roller batch mixer is adopted to mix afterwards, mixing rotating speed 30r/min≤v
1≤ 60r/min, incorporation time 20min≤t
1≤ 30min;
Prepare n group batch mixing altogether, 4≤n≤12, are labeled as T from inside to outside successively
1, T
2..., T
n-1, T
n;
The preparation method of gradient-structure comprises the steps:
1. successively blank is suppressed: adopt stainless steel mould, molding die mark is M
n, n=1,2,3,4 ... .., 4≤n≤12, wherein molding die M
nouter radius be greater than molding die M
n-1outer radius, raw material is successively inwardly suppressed from outermost layer according to correspondence order, compacting pressure be P
1, 60MPa≤P
1≤ 200MPa, compacting is divided into four-stage, and per dwell time in stage is respectively t
1, t
2, t
3, t
4, 15s≤t
1, t
2, t
3≤ 120s, 600s≤t
4≤ 800s, deflation time is respectively t
' 1, t
' 2, t
' 3, 15s≤t
' 1, t
' 2, t
' 3≤ 150s;
It is F that mold pressing obtains blank mark
n, n=1,2,3,4 ... .., 4≤n≤12, blank interface is semicircular arc, and external diameter is R
no, internal diameter is R
ni, n=2,3,4 ... .., 4≤n≤12, and adjacent two blank internal-and external diameters meet R
no=R
(n+1) i+ θ, 0.00mm≤θ≤0.02mm, core blank interface is semicircle, and radius is R
1, R
1=R
2i+ θ, above mold process repeats two cycles, and mold pressing second round obtains blank F'
n, n=1,2,3,4 ... .., 4≤n≤12, obtain blank F with period 1 mold pressing
nidentical;
2. surface activation process: adopt titanium dioxide suspension even application in blank inner surface, after dry, coating layer thickness is h
1, h
1=k θ, 0.6≤k≤1.2;
3. successively assemble: above-mentioned mold pressing is obtained blank F
nwith F'
nsuccessively outwards carry out splicing assembling according to correspondence order from innermost layer, the corner between adjacent two layers blank splicing seams is α, α=30 °, clockwise, obtains n layer blank F
nwith F'
nthe cylindrical coaxial complex blank F assembled, length is L
f, 5cm≤L
f≤ 60cm, radius is R
f, R
f=R
no+ (2n-2) θ, leaves standstill 30min; Insert in sintering mold S by cylindrical coaxial complex blank F, sintering mold S is the hollow cylinder that stainless steel material makes, and length is Ls, Ls>=L
f, inside radius is R
si, R
si=R
f+ k θ, 0.8≤k≤1.5;
4. complex sintered: to adopt gradient temperature repeatedly to sinter gradient porous coaxial complex blank F;
The sintering first stage, sintering temperature T
1, T
1be 1 ~ 200 DEG C, heat time heating time t
a1, t
a1for 63min, temperature retention time t
b1, t
b1for 30min;
Sintering second stage, sintering temperature T
2, T
2be 200 ~ 250 DEG C, heat time heating time t
a2, t
a2for 25min, temperature retention time t
b2, t
b2for 30min;
The sintering phase III, sintering temperature is T
3, T
3be 250 ~ 380 DEG C, heat time heating time t
a3, t
a3for 65min, temperature retention time t
b3, t
b3for 30min;
Sintering fourth stage, sintering temperature is T
4, T
4be 380 ~ 1000 DEG C, heat time heating time t
a4, t
a4for 207min, temperature retention time t
b4, t
b4for 5h, furnace cooling, obtains a kind of gradient β phase tricalcium phosphate bone alternate material.
four layers of gradient β phase tricalcium phosphate bone alternate material prepare example:
First 80g β phase tricalcium phosphate and the mixing of 20g polyvinyl alcohol is taken, add stearic acid wherein afterwards, in raw material, stearic addition successively successively decreases from inside to outside, is respectively 50.00g, 45.13g, 42.87g, 40.73g, adopt roller batch mixer to mix, mixing rotating speed 50r/min, incorporation time 30min, prepares 4 groups of batch mixings altogether, is labeled as T successively from inside to outside
1, T
2, T
3, T
4;
1. successively blank is suppressed: adopt stainless steel mould, molding die mark is M
n, n=1,2,3,4, wherein molding die M
nouter radius be greater than molding die M
n-1outer radius, by raw material T
nsuccessively inwardly suppress from outermost layer according to correspondence order, compacting pressure is P
1, P
1=100MPa, compacting is divided into four-stage, and per dwell time in stage is respectively t
1, t
2, t
3, t
4, 15s≤t
1, t
2, t
3≤ 120s, 600s≤t
4≤ 800s, deflation time is respectively t
' 1, t
' 2, t
' 3, 15s≤t
' 1, t
' 2, t
' 3≤ 150s; Blank mark is F
n, n=1,2,3,4, blank interface is semicircular arc, and external diameter is R
no, internal diameter is R
ni, n=2,3,4, and adjacent two blank internal-and external diameters meet R
no=R
(n+1) i+ θ, 0.00mm≤θ≤0.02mm, core blank interface is semicircle, and radius is R
1, R
1=R
2i+ θ, above mold process repeats two cycles, and mold pressing second round obtains blank F'
n, n=1,2,3,4, obtain blank F with period 1 mold pressing
nidentical;
2. surface activation process: configuration titanium dioxide suspension, concentration is 10g/l, and after suspension has configured, even application is in blank inner surface at once, and after dry, coating layer thickness is h
1, h
1=k θ, 0.6≤k≤1.2;
3. successively assemble: above-mentioned mold pressing is obtained blank F
nwith F'
n, n=1,2,3,4, successively outwards carry out splicing assembling according to correspondence order from innermost layer, the corner between adjacent two layers blank splicing seams is α, α=30 °, clockwise, obtains 4 layers of blank F
nwith F'
nthe cylindrical coaxial complex blank F assembled, length is L
f, 5cm≤L
f≤ 60cm, radius is R
f, R
f=R
no+ 6 θ, leave standstill 30min; Insert in sintering mold S by cylindrical coaxial complex blank F, sintering mold S is the hollow cylinder that stainless steel material makes, and length is Ls, Ls>=L
f, inside radius is R
si, R
si=R
f+ k θ, 0.8≤k≤1.5;
4. complex sintered: to adopt gradient temperature repeatedly to sinter gradient porous coaxial complex blank F;
The sintering first stage, sintering temperature T
1, T
1be 1 ~ 200 DEG C, heat time heating time t
a1, t
a1=63min, temperature retention time t
b1, t
b1=30min;
Sintering second stage, sintering temperature T
2, T
2be 200 ~ 250 DEG C, heat time heating time t
a2, t
a2=25min, temperature retention time t
b2, t
b2=30min;
The sintering phase III, sintering temperature is T
3, T
3be 250 ~ 380 DEG C, heat time heating time t
a3, t
a3=65min, temperature retention time t
b3, t
b3=30min;
Sintering fourth stage, sintering temperature is T
4, T
4be 380 ~ 1000 DEG C, heat time heating time t
a4, t
a4=207min, temperature retention time t
b4, t
b4=5h, furnace cooling, i.e. obtained four layers of gradient β phase tricalcium phosphate bone alternate material.The internal structure of four layers of gradient β phase tricalcium phosphate bone alternate material as shown in Figure 2, assembled by F1 and F'1 and obtain by ground floor blank 1 wherein.Second layer blank 2 is assembled by F2 and F'2 and is obtained.Third layer blank 3 is assembled by F3 and F'3 and is obtained.4th layer of blank 4 is assembled by F4 and F'4 and is obtained.
Claims (3)
1. the preparation method of a gradient β phase tricalcium phosphate bone alternate material, the method is through successively suppressing by β phase tricalcium phosphate, binding agent, pore-gas generating agent and surfactant blank, surfactant is adopted to carry out surface activation process, successively assembling is with complex sintered, obtained gradient β phase tricalcium phosphate bone alternate material.
2. the preparation method of a kind of gradient β phase tricalcium phosphate bone alternate material according to claim 1, is characterized in that:
Described binding agent is 120 order ~ 200 object pva powders;
Described pore-gas generating agent is stearic acid;
Described surfactant is titanium dioxide suspension.
3. the preparation method of a kind of gradient β phase tricalcium phosphate bone alternate material according to claim 1, the concrete steps of the method are: first the β phase tricalcium phosphate of mass percent 60% ~ 80% and the binding agent of mass percent 20% ~ 40% are mixed, add pore-gas generating agent wherein afterwards, in raw material, the content ecto-entad of pore-gas generating agent successively increases progressively, and pore-gas generating agent addition mark is m
n, n=1,2,3,4 ... .., 4≤n≤12, it is as follows that pore-gas generating agent addition increases progressively formula: m
n=m
1(1-5%)
n, the relation formula that increases progressively of number of apertures N and space average diameter γ is N=A γ
b, A is wherein proportionality coefficient, and B is the number of plies of distribution of pores; Roller batch mixer is adopted to mix afterwards, mixing rotating speed 30r/min≤v
1≤ 60r/min, incorporation time 20min≤t
1≤ 30min;
Prepare n group batch mixing altogether, 4≤n≤12, are labeled as T from inside to outside successively
1, T
2..., T
n-1, T
n;
The preparation method of gradient-structure comprises the steps:
1. successively blank is suppressed: adopt stainless steel mould, molding die mark is M
n, n=1,2,3,4 ... .., 4≤n≤12, wherein molding die M
nouter radius be greater than molding die M
n-1outer radius, raw material is successively inwardly suppressed from outermost layer according to correspondence order, compacting pressure be P
1, 60MPa≤P
1≤ 200MPa, compacting is divided into four-stage, and per dwell time in stage is respectively t
1, t
2, t
3, t
4, 15s≤t
1, t
2, t
3≤ 120s, 600s≤t
4≤ 800s, deflation time is respectively t
' 1, t
' 2, t
' 3, 15s≤t
' 1, t
' 2, t
' 3≤ 150s;
It is F that mold pressing obtains blank mark
n, n=1,2,3,4 ... .., 4≤n≤12, blank interface is semicircular arc, and external diameter is R
no, internal diameter is R
ni, n=2,3,4 ... .., 4≤n≤12, and adjacent two blank internal-and external diameters meet R
no=R
(n+1) i+ θ, 0.00mm≤θ≤0.02mm, core blank interface is semicircle, and radius is R
1, R
1=R
2i+ θ, above mold process repeats two cycles, and mold pressing second round obtains blank F'
n, n=1,2,3,4 ... .., 4≤n≤12, obtain blank F with period 1 mold pressing
nidentical;
2. surface activation process: adopt titanium dioxide suspension even application in blank inner surface, after dry, coating layer thickness is h
1, h
1=k θ, 0.6≤k≤1.2;
3. successively assemble: above-mentioned mold pressing is obtained blank F
nwith F'
nsuccessively outwards carry out splicing assembling according to correspondence order from innermost layer, the corner between adjacent two layers blank splicing seams is α, α=30 °, clockwise, obtains n layer blank F
nwith F'
nthe cylindrical coaxial complex blank F assembled, length is L
f, 5cm≤L
f≤ 60cm, radius is R
f, R
f=R
no+ (2n-2) θ, leaves standstill 30min; Insert in sintering mold S by cylindrical coaxial complex blank F, sintering mold S is the hollow cylinder that stainless steel material makes, and length is Ls, Ls>=L
f, inside radius is R
si, R
si=R
f+ k θ, 0.8≤k≤1.5;
4. complex sintered: to adopt gradient temperature repeatedly to sinter gradient porous coaxial complex blank F;
The sintering first stage, sintering temperature T
1, T
1be 1 ~ 200 DEG C, heat time heating time t
a1, t
a1for 63min, temperature retention time t
b1, t
b1for 30min;
Sintering second stage, sintering temperature T
2, T
2be 200 ~ 250 DEG C, heat time heating time t
a2, t
a2for 25min, temperature retention time t
b2, t
b2for 30min;
The sintering phase III, sintering temperature is T
3, T
3be 250 ~ 380 DEG C, heat time heating time t
a3, t
a3for 65min, temperature retention time t
b3, t
b3for 30min;
Sintering fourth stage, sintering temperature is T
4, T
4be 380 ~ 1000 DEG C, heat time heating time t
a4, t
a4for 207min, temperature retention time t
b4, t
b4for 5h, furnace cooling, obtains a kind of gradient β phase tricalcium phosphate bone alternate material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510101803.0A CN104645408B (en) | 2015-03-09 | 2015-03-09 | A kind of preparation method of gradient β phase tricalcium phosphate bone alternate material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510101803.0A CN104645408B (en) | 2015-03-09 | 2015-03-09 | A kind of preparation method of gradient β phase tricalcium phosphate bone alternate material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104645408A true CN104645408A (en) | 2015-05-27 |
| CN104645408B CN104645408B (en) | 2016-08-31 |
Family
ID=53237369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510101803.0A Expired - Fee Related CN104645408B (en) | 2015-03-09 | 2015-03-09 | A kind of preparation method of gradient β phase tricalcium phosphate bone alternate material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104645408B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833341A (en) * | 2016-06-06 | 2016-08-10 | 西安博恩生物科技有限公司 | Method for preparing artificial bone scaffolds with transverse mechanical structures |
| CN107376007A (en) * | 2017-06-15 | 2017-11-24 | 华南理工大学 | A kind of bionical non-homogeneous structural bio-vitric support and preparation method thereof |
| CN108480624A (en) * | 2018-04-13 | 2018-09-04 | 昆明理工大学 | A kind of powder is incremented by pressure setting and drawing method |
| CN108514655A (en) * | 2018-03-20 | 2018-09-11 | 山东大学 | A kind of preparation method of the decrystallized gradient porous calcium polyphosphate ceramic material in surface |
| CN108546107A (en) * | 2018-03-21 | 2018-09-18 | 山东大学深圳研究院 | A kind of gradient porous calcium polyphosphate ceramic material and preparation method thereof |
| CN110721010A (en) * | 2019-10-24 | 2020-01-24 | 重庆大学 | Radial gradient implant lattice structure and design method thereof |
| CN113041396A (en) * | 2021-03-08 | 2021-06-29 | 四川大学 | Preparation method of bracket material with gap gradient structure |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090222090A1 (en) * | 2005-05-11 | 2009-09-03 | Herman Mayr | System and implant for ligament reconstruction or bone or bone reconstruction |
| CN101690828A (en) * | 2009-09-29 | 2010-04-07 | 西北工业大学 | Preparation method of gradient porous bioceramic scaffold |
| US20100291178A1 (en) * | 2004-03-05 | 2010-11-18 | The Trustees Of Columbia University | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of bone |
| CN103896624A (en) * | 2014-03-20 | 2014-07-02 | 西安理工大学 | Method for preparing gradient porous ceramic by using centrifugal freeze drying technology |
-
2015
- 2015-03-09 CN CN201510101803.0A patent/CN104645408B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100291178A1 (en) * | 2004-03-05 | 2010-11-18 | The Trustees Of Columbia University | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of bone |
| US20090222090A1 (en) * | 2005-05-11 | 2009-09-03 | Herman Mayr | System and implant for ligament reconstruction or bone or bone reconstruction |
| CN101690828A (en) * | 2009-09-29 | 2010-04-07 | 西北工业大学 | Preparation method of gradient porous bioceramic scaffold |
| CN103896624A (en) * | 2014-03-20 | 2014-07-02 | 西安理工大学 | Method for preparing gradient porous ceramic by using centrifugal freeze drying technology |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833341A (en) * | 2016-06-06 | 2016-08-10 | 西安博恩生物科技有限公司 | Method for preparing artificial bone scaffolds with transverse mechanical structures |
| CN107376007A (en) * | 2017-06-15 | 2017-11-24 | 华南理工大学 | A kind of bionical non-homogeneous structural bio-vitric support and preparation method thereof |
| CN108514655A (en) * | 2018-03-20 | 2018-09-11 | 山东大学 | A kind of preparation method of the decrystallized gradient porous calcium polyphosphate ceramic material in surface |
| CN108514655B (en) * | 2018-03-20 | 2020-03-31 | 山东大学 | Preparation method of gradient porous calcium polyphosphate ceramic material with non-crystallized surface |
| CN108546107A (en) * | 2018-03-21 | 2018-09-18 | 山东大学深圳研究院 | A kind of gradient porous calcium polyphosphate ceramic material and preparation method thereof |
| CN108546107B (en) * | 2018-03-21 | 2021-05-28 | 山东大学深圳研究院 | Gradient porous calcium polyphosphate ceramic material and preparation method thereof |
| CN108480624A (en) * | 2018-04-13 | 2018-09-04 | 昆明理工大学 | A kind of powder is incremented by pressure setting and drawing method |
| CN108480624B (en) * | 2018-04-13 | 2019-09-13 | 昆明理工大学 | A kind of powder is incremented by pressure setting and drawing method |
| CN110721010A (en) * | 2019-10-24 | 2020-01-24 | 重庆大学 | Radial gradient implant lattice structure and design method thereof |
| CN110721010B (en) * | 2019-10-24 | 2021-10-26 | 重庆大学 | Radial gradient implant lattice structure and design method thereof |
| CN113041396A (en) * | 2021-03-08 | 2021-06-29 | 四川大学 | Preparation method of bracket material with gap gradient structure |
| CN113041396B (en) * | 2021-03-08 | 2021-11-30 | 四川大学 | Preparation method of bracket material with gap gradient structure |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104645408B (en) | 2016-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104645408B (en) | A kind of preparation method of gradient β phase tricalcium phosphate bone alternate material | |
| Tang et al. | Two-step freeze casting fabrication of hydroxyapatite porous scaffolds with bionic bone graded structure | |
| KR101908287B1 (en) | Porous bone substitutes and method for producing thereof | |
| CN101146557A (en) | Osteogenesis preparation and associated production method | |
| JP2009516544A (en) | Porous load-bearing ceramic or metal implant | |
| CN102293692A (en) | Bionic bone-repairing stent body with laminated structure and preparation method thereof | |
| Lindner et al. | Calcium phosphate scaffolds mimicking the gradient architecture of native long bones | |
| EP2991695B1 (en) | Ceramic bone substitute material and method for the production thereof | |
| WO2007128192A1 (en) | A medical strengthened-type porous bioceramics, its preparation method and application | |
| CN108348637B (en) | Large 3D porous scaffold made from active hydroxyapatite obtained by biomorphic transformation of natural structure and process for obtaining same | |
| CN101716368A (en) | Porous titanium artificial bone for restoring bone tissue and preparation method thereof | |
| CN216764734U (en) | Gradient mould for preparing composite microporous multi-structure bionic artificial bone | |
| CN107790723A (en) | A kind of preparation method of gradient titanium porous material | |
| EP2289468B1 (en) | Implant body and method for manufacturing | |
| Foroughi et al. | Mechanical evaluation of nHAp scaffold coated with poly-3-hydroxybutyrate for bone tissue engineering | |
| DE102012211390B4 (en) | SYNTHETIC BONE REPLACEMENT MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | |
| DE102015208632A1 (en) | Shaped bodies, process for their preparation and use | |
| US20120136456A1 (en) | Ceramic foam artificial bone | |
| KR20110129007A (en) | Graular porous bone substitute and method for preparing the same | |
| JP2006198276A (en) | Biomedical ceramic member, and its manufacturing method | |
| KR102353476B1 (en) | Ceramic-based 3D extrusion technique for producing biomimetic gradient porous ceramics | |
| KR101219871B1 (en) | Method for preparing porous strut of biomaterials and porous strut of biomaterials prepared thereby | |
| KR101241642B1 (en) | Fabrication Method of a Novel Artificial Cortical Bone using a Multi-pass Extrusion Process | |
| Hsu et al. | Fabrication of porous calcium phosphate bioceramics as synthetic cortical bone graft | |
| JP6642896B2 (en) | Method for producing porous ceramic body for medical use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160831 Termination date: 20170309 |