CN104814818A - Intravascular stent - Google Patents
Intravascular stent Download PDFInfo
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- CN104814818A CN104814818A CN201510197858.6A CN201510197858A CN104814818A CN 104814818 A CN104814818 A CN 104814818A CN 201510197858 A CN201510197858 A CN 201510197858A CN 104814818 A CN104814818 A CN 104814818A
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- intravascular stent
- support part
- flexible support
- support member
- stent according
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Abstract
The invention provides an intravascular stent. The intravascular stent is in tubular shape and comprises a plurality of support units uniformly distributed in the axial direction, and a connector connecting the plurality of support units into a whole. Every support unit is composed of a flexible support part and a rigid support part connected inside the flexible support part, and the flexible support part and/or the rigid support part is a hollow tube with a plurality of pores formed in the surface; medicine carrier balloons are arranged inside the inner cavities of the hollow tubes and at the pores. The intravascular stent is characterized by avoiding injury to vascular walls and obtaining high mechanical properties and meanwhile has the advantages of being capable of carrying medicines, high in carrying capacity and convenient to medicine-release.
Description
Technical field
The present invention relates to a kind of intravascular stent, belong to technical field of medical instruments.
Background technology
1977 in the world first case percutaneous coronary intervene operation (PCI) complete in Switzerland, this example operation expands by the left anterior descending branch stenosis of sacculus to patient, and achieves successfully.But after balloon expandable, the restenosis rate of blood vessel is very high, more than 50%.Main cause is, after blood vessel is expanded and removed external force, blood vessel can elastical retraction.In the eighties in last century, invent and be widely used in intravascular stent coronarius, mainly contain the metallic blood vessel bracket that rustless steel, cochrome or Nitinol are made, after in these stent implant, a lasting mechanical support can be provided to blood vessel, avoid the elastical retraction of blood vessel, reduce the restenosis rate of lesion vessels.But because the Permanent implantation of support, support can cause neointimal hyperplasia as foreign body, and the restenosis ratio of blood vessel is also very high.Since 2003, the application of drug stent makes the restenosis rate of blood vessel drop to about 10%.But drug stent is still forever present in body, in mechanical property, very big-difference is there is as between the support of foreign body and vascular tissue, the chronic injury of blood vessel can be caused, later stage can cause media atrophy, neointimal hyperplasia, the final restenosis that also can cause blood vessel, thus limit the further reduction of vascular restenosis rate.For child patient, implant the increase gradually of the intravascular stent meeting line artery of fixed dimension, the needs of its growth promoter can not be adapted to.
Above-mentioned two kinds of interventional therapeutic techniques for angiostenosis have shortcoming: adopt balloon expandable blood vessel, although short run effect is better, because the elastical retraction of blood vessel, the restenosis rate in later stage is very high; At Ink vessel transfusing implanted metal support, comprise bare bracket and drug stent, narrow blood vessel can be expanded, and a lasting mechanical support is provided, but can blood vessel internal membrane damage be caused in metal rack process of expansion, bring out vascellum endometrial hyperplasia and cause restenosis.Metal rack also exists thrombosis, goes out blood coagulation complication, flexibility does not mate, metal object forever retains in body can increase the defects such as restenosis incidence rate at a specified future date.
Therefore, the mechanical property that has of the success or failure of Stent and support itself is closely bound up.The shortening of support its axial direction when expanding can cause support to cause damage at the two ends of blood vessel wall, thus brings out the generation of vascular lesion position restenosis further.Therefore axial shortening is the very important mechanical property of intravascular stent, and conventional axial shortening rate represents the excellent of this index; Axial shortening rate reflects the change of stent expansion anterior-posterior length, and it is related to the degree of accuracy selected and locate of stent length.Therefore, the success of axial shortening performance to stenting of support plays vital effect.But existing supporting structure is all difficult to avoid it axially shortening after support is expanded completely.
Medicine carrying on intravascular stent, can treat vascular restenosis in the mode of topical, so create coating stent of medicine.But the drug release rate of medication coat is uncontrollable, and drug loading is limited, and therapeutic effect is not obvious.
Summary of the invention
The present invention, in order to solve the above-mentioned defect and deficiency that exist in prior art, provides a kind of intravascular stent, not only has and prevents from causing damage, feature that mechanical property is good to blood vessel wall, and have can large, the drug release advantage easily of medicine carrying, drug loading.
For solving the problems of the technologies described above, the invention provides a kind of intravascular stent, described intravascular stent is tubulose, the connector comprise several support units equally distributed vertically, connecting support unit described in several, described support unit comprise flexible support part and in be connected on rigid support member in described flexible support part, described flexible support part and/or rigid support member are that surface uniform distributes the hollow pipe of several micropores, in described hollow pipe, intracavity is provided with drug holding theca, and described drug holding theca is placed in described micropore place.
Preferably, described flexible support part is oval, and described rigid support member is rhombus.
Preferably, the ratio of the long and short diameter of described flexible support part is 3:2.
Preferably, the material of described flexible support part is magnesium alloy.
Preferably, the material of described rigid support member is medical stainless steel or cochrome.
Preferably, described connector is straight line connecting rod.
Preferably, the length of described intravascular stent is 2-30cm.
The Advantageous Effects that the present invention reaches:
Support unit of the present invention is made up of flexible support part and rigid support member, and be connected in rigid support member in flexible support part, in use, flexible support part is only had to contact blood vessel wall, can not cause damage to blood vessel wall, and simultaneously, rigid support member is used to provide mechanical support, the restenosis of anti-hemostatic tube, effectively reduces the restenosis rate of blood vessel; In addition, described flexible support part and/or rigid support member are designed to hollow pipe, and arrange drug holding theca in hollow pipe, can be used for medicine carrying, and drug loading is comparatively large, the micropore of release medicine is set at drug holding theca place, be conducive to discharging fast and uniformly of medicine, effectively improve therapeutic effect.In order to better ensure that flexible support part does not cause damage to blood vessel wall, flexible support part is designed to ellipse, and adopts magnesium alloy material.In order to better ensure the mechanical property of rigid support member, rigid support member is designed to rhombus, and material adopts medical stainless steel or cochrome; Straight line connecting rod is adopted between support unit, make the radial support power that intravascular stent can keep higher after expansion, there is again axially zero shortening, be conducive to the positioning precision after improving intravascular stent implantation and further reduce the loss rate of support injection to blood vessel wall.
Accompanying drawing explanation
Fig. 1 structure of the present invention launches schematic diagram;
Fig. 2 hollow tubular structure schematic diagram of the present invention.
Detailed description of the invention
In order to the technique effect that auditor can better understand technical characteristic of the present invention, technology contents and reach, now accompanying drawing of the present invention is described in detail in conjunction with the embodiments.But shown accompanying drawing, just in order to technical scheme of the present invention is better described, is not actual proportions of the present invention and best allocation, so, ask auditor not with regard to ratio and the configuration of accompanying drawing, limit claims of the present invention.
Below in conjunction with drawings and Examples, patent of the present invention is further illustrated.
As shown in Figure 1-2, the invention provides a kind of intravascular stent, described intravascular stent is tubulose, the connector 2 comprise several support units 1 equally distributed vertically, connecting support unit described in several 1, described support unit 1 comprise flexible support part 11 and in be connected on rigid support member 12 in described flexible support part 11, described flexible support part 11 and/or rigid support member 12 to distribute the hollow pipe of several micropores 3 for surface uniform, in described hollow pipe, intracavity is provided with drug holding theca 4, and described drug holding theca 4 is placed in described micropore 3 place.
Support unit 1 of the present invention is made up of flexible support part 11 and rigid support member 12, and be connected in rigid support member 12 in flexible support part 11, in use, flexible support part 11 is only had to contact blood vessel wall, can not cause damage to blood vessel wall, and simultaneously, rigid support member 12 is used to provide mechanical support, the restenosis of anti-hemostatic tube, effectively reduces the restenosis rate of blood vessel; In addition, described flexible support part 11 and/or rigid support member 12 are designed to hollow pipe, and drug holding theca 4 is set in hollow pipe, can be used for medicine carrying, and drug loading is larger, the micropore 3 of release medicine is set at drug holding theca 4 place, is conducive to discharging fast and uniformly of medicine, effectively improves therapeutic effect.
In order to better ensure that flexible support part 11 pairs of blood vessel wall do not cause damage, flexible support part 11 is designed to ellipse, and adopts magnesium alloy material.In order to better ensure the mechanical property of rigid support member 12, rigid support member 12 is designed to rhombus, and material adopts medical stainless steel or cochrome;
Described connector 2 is straight line connecting rod, straight line connecting rod is adopted between support unit 1, make the radial support power that intravascular stent can keep higher after expansion, there is again axially zero shortening, be conducive to the positioning precision after improving intravascular stent implantation and further reduce the loss rate of support injection to blood vessel wall.
Preferably, the ratio of the long and short diameter of described flexible support part 11 is 3:2.
Preferably, the length of described intravascular stent is 2-30cm.
Below disclose the present invention with preferably embodiment, so it is not intended to limiting the invention, allly takes equivalent replacement or technical scheme that the scheme of equivalent transformation obtains, all drops in protection scope of the present invention.
Claims (7)
1. an intravascular stent, it is characterized in that: described intravascular stent is tubulose, the connector comprise several support units equally distributed vertically, connecting support unit described in several, described support unit comprise flexible support part and in be connected on rigid support member in described flexible support part, described flexible support part and/or rigid support member are that surface uniform distributes the hollow pipe of several micropores, in described hollow pipe, intracavity is provided with drug holding theca, and described drug holding theca is placed in described micropore place.
2. intravascular stent according to claim 1, is characterized in that: described flexible support part is for oval, and described rigid support member is rhombus.
3. intravascular stent according to claim 2, is characterized in that: the ratio of the long and short diameter of described flexible support part is 3:2.
4. intravascular stent according to claim 1, is characterized in that: the material of described flexible support part is magnesium alloy.
5. intravascular stent according to claim 1, is characterized in that: the material of described rigid support member is medical stainless steel or cochrome.
6. intravascular stent according to claim 1, is characterized in that: described connector is straight line connecting rod.
7. the intravascular stent according to claim 1-6 any one, is characterized in that: the length of described intravascular stent is 2-30cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197858.6A CN104814818A (en) | 2015-04-24 | 2015-04-24 | Intravascular stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197858.6A CN104814818A (en) | 2015-04-24 | 2015-04-24 | Intravascular stent |
Publications (1)
| Publication Number | Publication Date |
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| CN104814818A true CN104814818A (en) | 2015-08-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510197858.6A Pending CN104814818A (en) | 2015-04-24 | 2015-04-24 | Intravascular stent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938158A (en) * | 2018-07-23 | 2018-12-07 | 上海市第人民医院 | A kind of load medicine intravascular stent based on nano-medicament carrier |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998007386A1 (en) * | 1996-08-22 | 1998-02-26 | Thomas Ischinger | Tubular stent |
| EP0873728A2 (en) * | 1997-04-25 | 1998-10-28 | W.C. Heraeus GmbH | Radial expandable support device (stent) II |
| US6200337B1 (en) * | 1996-03-10 | 2001-03-13 | Terumo Kabushiki Kaisha | Implanting stent |
| US20060265048A1 (en) * | 2005-05-18 | 2006-11-23 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
| CN101366667A (en) * | 2008-09-25 | 2009-02-18 | 中国科学院长春光学精密机械与物理研究所 | Ductwork type coronary stent self-carrying medicament sustained-release |
| CN101732114A (en) * | 2008-11-04 | 2010-06-16 | 微创医疗器械(上海)有限公司 | Coronary artery stent with medicine carrying grooves |
| CN103156708A (en) * | 2013-02-01 | 2013-06-19 | 浙江大学医学院附属第二医院 | Artificial lens with drug sustained release micro-capsules inlaid on loop and manufacturing method thereof |
| CN103315833A (en) * | 2013-06-17 | 2013-09-25 | 苏州爱瑞德医疗科技有限公司 | Targeted drug delivery tube woven intravascular stent |
| CN104127268A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent firm in supporting |
| CN104220030A (en) * | 2012-04-13 | 2014-12-17 | 美敦力瓦斯科尔勒公司 | Hollow drug-filled stent and method of forming hollow drug-filled stent |
| CN204698764U (en) * | 2015-04-24 | 2015-10-14 | 苏州固基电子科技有限公司 | A kind of intravascular stent |
-
2015
- 2015-04-24 CN CN201510197858.6A patent/CN104814818A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6200337B1 (en) * | 1996-03-10 | 2001-03-13 | Terumo Kabushiki Kaisha | Implanting stent |
| WO1998007386A1 (en) * | 1996-08-22 | 1998-02-26 | Thomas Ischinger | Tubular stent |
| EP0873728A2 (en) * | 1997-04-25 | 1998-10-28 | W.C. Heraeus GmbH | Radial expandable support device (stent) II |
| US20060265048A1 (en) * | 2005-05-18 | 2006-11-23 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
| CN101366667A (en) * | 2008-09-25 | 2009-02-18 | 中国科学院长春光学精密机械与物理研究所 | Ductwork type coronary stent self-carrying medicament sustained-release |
| CN101732114A (en) * | 2008-11-04 | 2010-06-16 | 微创医疗器械(上海)有限公司 | Coronary artery stent with medicine carrying grooves |
| CN104220030A (en) * | 2012-04-13 | 2014-12-17 | 美敦力瓦斯科尔勒公司 | Hollow drug-filled stent and method of forming hollow drug-filled stent |
| CN103156708A (en) * | 2013-02-01 | 2013-06-19 | 浙江大学医学院附属第二医院 | Artificial lens with drug sustained release micro-capsules inlaid on loop and manufacturing method thereof |
| CN103315833A (en) * | 2013-06-17 | 2013-09-25 | 苏州爱瑞德医疗科技有限公司 | Targeted drug delivery tube woven intravascular stent |
| CN104127268A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent firm in supporting |
| CN204698764U (en) * | 2015-04-24 | 2015-10-14 | 苏州固基电子科技有限公司 | A kind of intravascular stent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938158A (en) * | 2018-07-23 | 2018-12-07 | 上海市第人民医院 | A kind of load medicine intravascular stent based on nano-medicament carrier |
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Application publication date: 20150805 |