CN104971377A - Liquid wound glue and preparation method - Google Patents
Liquid wound glue and preparation method Download PDFInfo
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- CN104971377A CN104971377A CN201510355198.XA CN201510355198A CN104971377A CN 104971377 A CN104971377 A CN 104971377A CN 201510355198 A CN201510355198 A CN 201510355198A CN 104971377 A CN104971377 A CN 104971377A
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Abstract
The invention discloses liquid wound glue and a preparation method. The liquid wound glue comprises the following crude drugs in weight proportion: 10-50 parts of polyurethane, 20-60 parts of a highly volatile mixed solvent, 2-6 parts of a thickening agent, 0.5-1.5 parts of a bactericide, 20-60 parts of isopropanol, 15-30 parts of glycerin, 2-6 parts of chitin, 2.5-5 parts of an aroma enhancement agent, 3-10 parts of chitosan and 5-30 parts of purified water; the liquid wound glue is prepared through the following steps: mixing the polyurethane, glycerin, ethyl acetate and methylcellulose so as to prepare into a mixed solution A; mixing the bactericide, isopropanol, chitin and purified water, adding chitosan, clove oil and tea tree oil and mixing so as to prepare into a mixed solution B; mixing the mixed solution A and the mixed solution B and adjusting Ph. The liquid wound glue provided by the invention forms an elastic, soft, air-permeable, waterproof and antibacterial glue film, has a good bleeding stopping effect, can prevent wound infection, accelerates healing, restrains wound suppuration, does not adhere newly formed tissue, and is fragrant in smell and non-irritant after being applied.
Description
[technical field]
The present invention relates to the technical field of medical supplies, particularly a kind of technical field of liquid wound glue.
[background technology]
In daily life and work, the body surface wound caused by a variety of causes is very common, as scratch, scald etc.Still traditional adhesive bandage occupies staple market in the market, and traditional adhesive bandage is by a microscler adhesive plaster, and the sliver that centre is accompanied by the dipped medicine of a fritter is formed, i.e. plain cloth adhesive plaster and adsorptive pads composition.Due to its structure and the restriction of size, adhesive bandage can only be used for the wound emergence therapeutic of fritter, thus plays temporary transient hemostasis, the effect of protection wound surface.But it should be noted that the time used is unsuitable long, may not exceed 24 hours.If after using it for a long time, the outer field adhesive plaster of adhesive bandage is airtight, the skin whitening deliquescing of wound and wound circumference will be made to cause the infection of the secondary of antibacterial, wound will be made so more to worsen.Be not employ waterproof band-aid just can contact with water for a long time.If the skin of adhesive bandage and wound circumference sticks to obtain imprecision, especially privileged sites, as finger tip, knee and ancon etc., waterproof effect is also bad, and affects attractive in appearance.Traditional wound care product has ointments preparation etc., and the easy pollution clothes of ointments preparation, also easily causes the pollution again of wound, is therefore necessary to be improved prior art.
Liquid bandage is a kind of novel Wound dressing, and primarily of filmogen and solvent composition, and most of product also added and has curative functional mass.Liquid in the market protects wound product mostly containing alcohol component, can cause than stronger sensation of pricking in use, affect its result of use; In addition, there is larger abnormal flavour during use, and the functional materials added is mostly chemicals, has certain security risk, is not suitable for the use such as infant and anemia of pregnant woman.
[summary of the invention]
Object of the present invention solves the problems of the prior art exactly, a kind of liquid wound glue and preparation method are proposed, liquid-transparent product is made by using film forming component and evaporating solution, form elastomeric flexible, air permeable waterproof, antibacterial glued membrane, have good haemostatic effect, prevent wound infection, healing acceleration and suppress wound suppuration, the tissue that adhesion is newly formed, fragrant odour, coats stingless excitation.
For achieving the above object, the present invention proposes a kind of liquid wound glue, comprise the crude drug of following weight proportion:
Polyurethanes 10 ~ 50 parts, effumability mixed solvent 20 ~ 60 parts, thickening agent 2 ~ 6 parts, antibacterial 0.5 ~ 1.5 part, isopropyl alcohol 20 ~ 60 parts, glycerol 15 ~ 30 parts, chitin 2 ~ 6 parts, fumet 2.5 ~ 5 parts, chitosan 3 ~ 10 parts, purified water 5 ~ 30 parts;
Wherein, solid part unit is liquid part unit that g is corresponding is ml, or solid part unit be liquid part unit that Kg is corresponding is L.
As preferably, ethyl acetate selected by described effumability mixed solvent, and antibacterial selects chlorhexidine series bactericidal agent, and antibacterial specifically selects chlorhexidine gluconate, and thickening agent selects methylcellulose.
As preferably, described fumet selects Oleum Caryophylli and tea tree oil, Oleum Caryophylli 0.5 ~ 1 part, tea tree oil 2 ~ 4 parts.
As preferably, comprise the crude drug of following weight proportion: polyurethanes 40 parts, ethyl acetate 40 parts, methylcellulose 5 parts, chlorhexidine gluconate 1.2 parts, isopropyl alcohol 40 parts, glycerol 20 parts, chitin 5 parts, Oleum Caryophylli 0.8 part, tea tree oil 3 parts, chitosan 8 parts, purified water 30 parts.
As preferably, comprise the crude drug of following weight proportion: polyurethanes 35 parts, ethyl acetate 30 parts, methylcellulose 4 parts, chlorhexidine gluconate 0.8 part, isopropyl alcohol 35 parts, glycerol 20 parts, chitin 4 parts, Oleum Caryophylli 0.6 part, tea tree oil 3.5 parts, chitosan 6 parts, purified water 20 parts.
The present invention proposes a kind of preparation method of liquid wound glue, comprise concrete steps as follows:
A. by filmogen polyurethanes, glycerol, effumability mixed solvent ethyl acetate, thickening agent methylcellulose according to proportioning mix homogeneously, water bath with thermostatic control stir, make mixed solution A;
B. by antibacterial chlorhexidine gluconate, isopropyl alcohol, chitin, purified water mix homogeneously, stir and fully dissolve, then add chitosan, continue stirring and chitosan is dissolved completely, then add Oleum Caryophylli, tea tree oil mix homogeneously, make mixed solution B;
C. by mixed solution A and mixed solution B mix homogeneously, stir, regulate pH to 4.0 ~ 5.5, obtain liquid wound glue.
As preferably, described step a) in, bath temperature is 40 ~ 60 DEG C, and mixing speed is 500 ~ 800rpm.
As preferably, described step b) in, mixing speed is 500 ~ 800rpm, and mixing time is 40 ~ 60 minutes.
Beneficial effect of the present invention:
1, the present invention makes liquid-transparent product by using film forming component and evaporating solution; volatilize immediately after smearing; form elastomeric flexible, air permeable waterproof, antibacterial glued membrane; combine the advantage of adhesive bandage and the dressing of novel wound specialty; transparent adhesive film sustainable protection wound can also observe wound healing situation simultaneously; can play the effect preventing wound infection and protection, isolation waterproof, can prevent antibacterial intrusion.
2, good haemostatic effect is had, and suppress wound suppuration, there is the effects such as hemostasis, pain relieving, antiinflammatory, sterilization, under summary sour environment, maintain moist environment can make wound better heal, use the situation not having hydrocolloid seepage for many days, hydrogel covers can not injure granulation tissue, and when being attached to wound, surface is without incrustation, and wound healing effect is very good.
3, not by the restriction of shape of wound size, the tissue that adhesion is newly formed, superior absorbability and speed, can be used for wound in a big way; Fragrant odour, coats stingless excitation.
Feature of the present invention and advantage will be described in detail by embodiment.
[detailed description of the invention]
Medicament selection of the present invention:
1, polyurethanes
Polyurethane elastomer has the advantages such as good tensile strength, tearing toughness, resistance to impact, wearability, weatherability, hydrolytic resistance, oil resistivity.
Polyurethane has excellent biocompatible, is therefore widely used as bio-medical material gradually.Wound dressings polyurethane, can form glued membrane, and filminess also can maintain high strength, and flexibility is good.
2, chlorhexidine gluconate
Chlorhexidine is a kind of biguanide chlorobenzene, has quite wide antimicrobial acivity, Cidex-7, has great broad-spectrum antibacterial, bactericidal action, to gram positive bacteria and gram negative bacteria all effective.External hands, skin degerming, rinse wound, the effect of chlorhexidine starts slowly than alcohols, but it has suitable persistence (residue attachment) on skin, and skin has lasting chemical anti-microbial active matter.When Long-term clinical uses, cause that contact is responsive or light activated probability is all very little.
Chlorhexidine salt has Chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine gluconate at common disinfectants, domestic clinical conventional chlorhexidine acetate, the clinical main use chlorhexidine gluconate of European countries.There is certain zest and anaphylaxis in chlorhexidine acetate, untoward reaction is more.Chlorhexidine gluconate zest is little, and sensitization is little.
Chlorhexidine gluconate and alcohol solution interworking, disinfection effect is stronger, and Continuous sterilization is effective, but after using chlorhexidine gluconate, avoids alkaline matter to reduce its bactericidal activity.
3, chitosan
Containing amino in solution after chitosan dissolves, these amino are by carrying out anti-bacteria in conjunction with negatron.The Antibacterial activity of chitosan, makes it have a wide range of applications in fields such as medicine, weaving and food.
Chitosan has the effect promoting blood coagulation, can be used as hemorrhage.It also can be used for Wound filling material, has sterilizing, promotes wound healing, absorbs the effects such as Wound exudate, not easily syneresis.
Chitosan-phospholipid complex has good antibacterial activity, can suppress the growth and breeding of some funguses, antibacterial and virus.Due to the interaction of negative charge on the positive charge of chitosan molecule and bacterial cell membrane, intracellular protease and other compositions are leaked, thus reach antibacterial, bactericidal action.Research finds, consumption is that the breeding of chitosan lactate to colibacillus of 0.12mg/ml has good inhibitory action, and glutamate to yeast as the procreation of saccharomyces cerevisiae also has good inhibition, further, the chitosan lactate of 1mg/mL can make yeast lose activity completely in 17min.Due to chitosan can to infiltrate in the core of antibacterial and and DNA combine, the synthesis of suppression mRNA, thus hinder the synthesis of mRNA and protein, reaches antibacterial action.Chitosan gel rubber can be used as the carrier of antibiotics, has the function of hemostasis, antiinflammatory and wound healing.
4, Oleum Caryophylli, tea tree oil
Oleum Caryophylli has the effect of certain pain relieving, alleviates wound pain and Promotive union, fragrant odour.Flos Caryophylli can send a kind of fruit wine fragrance of the similar wild fruit fermented, and can be in harmonious proportion the abnormal smells from the patient of wound glue.
Tea tree oil can antimicrobial, has characteristic perfume and antibacterial, antiinflammatory, anthelmintic, kills effect of demodicid mite.Tea tree oil is a kind of natural disinfectant, has very great help for treatment numerous disease, wound.As incised wound, scratch, by insect bite, acne, burn, vaginal infection, tinea etc.Tea tree oil is widely used in cosmetics, toilet articles and veterinary product.When the concentration of tea tree oil is 15% about substantially, directly make disinfectant for consumer.Almost unmanned irritated lower than the tea tree oil of 25% for concentration, as a kind of safe disinfectant.The fragrance of tea tree oil is also for being in harmonious proportion the abnormal smells from the patient of wound glue.
5, ethyl acetate
Ethyl acetate is volatile, and drying and forming-film speed is fast, and volatile solvent soln coordinates with film forming component, and in addition, ethyl acetate also has fruital taste.
Erythema phase, chronic wounds, need skin-nourishing protective agent and ultra-thin hydrocolloid, improve skin microcirculation and nutrition, strengthens skin barrier and resistance.Mummification necrosis phase wound, needs mechanical debridement and hydrogel, accelerates the decomposition of slough.Inflammatory reaction phase, suppurative wound, need alginic acid salt and lipid glue, accelerates the decomposition of slough, absorbs sepage.Granulation trophophase wound, needs hydrocolloid and lipid glue, promotes the release of various somatomedin, stimulates angeogenesis.Epithelium Formation period wound, needs ultra-thin hydrocolloid and lipid glue, and epithelial cell is in wet environment, and speed of dividing a word with a hyphen at the end of a line is faster.Hydrogel has excellent biocompatibility, anticoagulant property, uses moisturizing wound glue, can accelerating wound healing and promotion tissue growth.
Below in conjunction with detailed description of the invention, the present invention is described in further detail.
Embodiment 1
Formula:
Polyurethanes 40 parts, ethyl acetate 40 parts, methylcellulose 5 parts, chlorhexidine gluconate 1.2 parts, isopropyl alcohol 40 parts, glycerol 20 parts, chitin 5 parts, Oleum Caryophylli 0.8 part, tea tree oil 3 parts, chitosan 8 parts, purified water 30 parts.
By filmogen polyurethanes, glycerol, effumability mixed solvent ethyl acetate, thickening agent methylcellulose according to proportioning mix homogeneously, water bath with thermostatic control is stirred, and bath temperature is 50 DEG C, and mixing speed is 500rpm, makes mixed solution A;
By antibacterial chlorhexidine gluconate, isopropyl alcohol, chitin, purified water mix homogeneously, stir and fully dissolve, add chitosan again, continuing stirring makes chitosan dissolve completely, add Oleum Caryophylli, tea tree oil mix homogeneously again, mixing speed is 500rpm, and mixing time is 40 minutes, makes mixed solution B;
By mixed solution A and mixed solution B mix homogeneously, stir, regulate pH to 5.0, obtain liquid wound glue.
Embodiment 2
Formula: polyurethanes 35 parts, ethyl acetate 30 parts, methylcellulose 4 parts, chlorhexidine gluconate 0.8 part, isopropyl alcohol 35 parts, glycerol 20 parts, chitin 4 parts, Oleum Caryophylli 0.6 part, tea tree oil 3.5 parts, chitosan 6 parts, purified water 20 parts.
Preparation method is identical with embodiment 1.
The said goods is poured in suitable packing container and can use, wound surface is smeared gently during use, make its uniform fold wound surface, after several minutes, smear medicinal liquid place and can form one deck film body, this film body can be combined closely with skin, wound face is closed rapidly, intercept antibacterial foreign body to invade, have easy to use, water proof, absorptive tissue liquid oozes out, ventilative, do not pollute clothes, without anaphylaxis and drug resistance, protection cambium, promote wound healing, be not subject to the restriction of shape of wound and residing position, the activity of dispensing area energy freely, effectively prevent the features such as wound infection.
The present invention makes liquid-transparent product by using film forming component and evaporating solution, volatilize immediately after smearing, form elastomeric flexible, air permeable waterproof, antibacterial glued membrane, combine the advantage of adhesive bandage and the dressing of novel wound specialty, transparent adhesive film sustainable protection wound can also observe wound healing situation simultaneously, the effect preventing wound infection and protection can be played, under summary sour environment, maintain moist environment can make wound better heal, use the situation not having hydrocolloid seepage for many days, isolation waterproof, there is good haemostatic effect, and suppress wound suppuration, hydrogel covers can not injure granulation tissue, antibacterial intrusion can be prevented, when being attached to wound, surface is without incrustation, wound healing effect is very good, the tissue that adhesion is newly formed, superior absorbability and speed, can be used for wound in a big way.Fragrant odour, coats stingless excitation.
Above-described embodiment is to explanation of the present invention, is not limitation of the invention, anyly all belongs to protection scope of the present invention to the scheme after simple transformation of the present invention.
Claims (8)
1. a liquid wound glue, is characterized in that: the crude drug comprising following weight proportion:
Polyurethanes
10 ~ 50 parts, effumability mixed solvent 20 ~ 60 parts, thickening agent 2 ~ 6 parts, antibacterial 0.5 ~ 1.5 part, isopropyl alcohol 20 ~ 60 parts, glycerol 15 ~ 30 parts, chitin 2 ~ 6 parts, fumet 2.5 ~ 5 parts, chitosan 3 ~ 10 parts, purified water 5 ~ 30 parts;
Wherein, solid part unit is liquid part unit that g is corresponding is ml, or solid part unit be liquid part unit that Kg is corresponding is L.
2. a kind of liquid wound glue as claimed in claim 1, is characterized in that: ethyl acetate selected by described effumability mixed solvent, and antibacterial selects chlorhexidine series bactericidal agent, and antibacterial specifically selects chlorhexidine gluconate, and thickening agent selects methylcellulose.
3. a kind of liquid wound glue as claimed in claim 1, is characterized in that: described fumet selects Oleum Caryophylli and tea tree oil, Oleum Caryophylli 0.5 ~ 1 part, tea tree oil 2 ~ 4 parts.
4. a kind of liquid wound glue as claimed in claim 1, is characterized in that: the crude drug comprising following weight proportion: polyurethanes 40 parts, ethyl acetate 40 parts, methylcellulose 5 parts, chlorhexidine gluconate 1.2 parts, isopropyl alcohol 40 parts, glycerol 20 parts, chitin 5 parts, Oleum Caryophylli 0.8 part, tea tree oil 3 parts, chitosan 8 parts, purified water 30 parts.
5. a kind of liquid wound glue as claimed in claim 1, is characterized in that: the crude drug comprising following weight proportion: polyurethanes 35 parts, ethyl acetate 30 parts, methylcellulose 4 parts, chlorhexidine gluconate 0.8 part, isopropyl alcohol 35 parts, glycerol 20 parts, chitin 4 parts, Oleum Caryophylli 0.6 part, tea tree oil 3.5 parts, chitosan 6 parts, purified water 20 parts.
6. the preparation method of a kind of liquid wound glue as claimed in claim 1, is characterized in that: comprise concrete steps as follows:
A. by filmogen polyurethanes, glycerol, effumability mixed solvent ethyl acetate, thickening agent methylcellulose according to proportioning mix homogeneously, water bath with thermostatic control stir, make mixed solution A;
B. by antibacterial chlorhexidine gluconate, isopropyl alcohol, chitin, purified water mix homogeneously, stir and fully dissolve, then add chitosan, continue stirring and chitosan is dissolved completely, then add Oleum Caryophylli, tea tree oil mix homogeneously, make mixed solution B;
C. by mixed solution A and mixed solution B mix homogeneously, stir, regulate pH to 4.0 ~ 5.5, obtain liquid wound glue.
7. the preparation method of a kind of liquid wound glue as claimed in claim 6, is characterized in that: described step a) in, bath temperature is 40 ~ 60 DEG C, and mixing speed is 500 ~ 800rpm.
8. the preparation method of a kind of liquid wound glue as claimed in claim 6, is characterized in that: described step b) in, mixing speed is 500 ~ 800rpm, and mixing time is 40 ~ 60 minutes.
Priority Applications (1)
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| CN201510355198.XA CN104971377A (en) | 2015-06-23 | 2015-06-23 | Liquid wound glue and preparation method |
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| CN201510355198.XA CN104971377A (en) | 2015-06-23 | 2015-06-23 | Liquid wound glue and preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
| CN106178096A (en) * | 2016-08-30 | 2016-12-07 | 张阳 | A kind of wound fluid film and preparation method thereof |
| CN108135745A (en) * | 2016-06-29 | 2018-06-08 | 艾威医药科技（芜湖）有限公司 | Composition is formed for effective novel fast deposition film for the treatment of of wounds |
| CN109224114A (en) * | 2018-10-10 | 2019-01-18 | 广州润虹医药科技股份有限公司 | A kind of foam dressing and its preparation method and application |
| CN115887747A (en) * | 2022-10-22 | 2023-04-04 | 湖南中腾湘岳生物科技有限公司 | Liquid wound protection material containing nano-pore flexible membrane and preparation method thereof |
| CN116531433A (en) * | 2023-05-09 | 2023-08-04 | 牡丹江医学院 | Liquid wound healing agent of garden burnet and application thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
| CN108135745A (en) * | 2016-06-29 | 2018-06-08 | 艾威医药科技（芜湖）有限公司 | Composition is formed for effective novel fast deposition film for the treatment of of wounds |
| CN106178096A (en) * | 2016-08-30 | 2016-12-07 | 张阳 | A kind of wound fluid film and preparation method thereof |
| CN109224114A (en) * | 2018-10-10 | 2019-01-18 | 广州润虹医药科技股份有限公司 | A kind of foam dressing and its preparation method and application |
| CN109224114B (en) * | 2018-10-10 | 2021-06-04 | 广州润虹医药科技股份有限公司 | Foam dressing and preparation method and application thereof |
| CN115887747A (en) * | 2022-10-22 | 2023-04-04 | 湖南中腾湘岳生物科技有限公司 | Liquid wound protection material containing nano-pore flexible membrane and preparation method thereof |
| CN115887747B (en) * | 2022-10-22 | 2024-02-20 | 湖南中腾湘岳生物科技有限公司 | Liquid wound protection material containing nano-pore flexible membrane and preparation method thereof |
| CN116531433A (en) * | 2023-05-09 | 2023-08-04 | 牡丹江医学院 | Liquid wound healing agent of garden burnet and application thereof |
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