CN105326651A - Mouthwash and preparation method thereof - Google Patents
Mouthwash and preparation method thereof Download PDFInfo
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- CN105326651A CN105326651A CN201510815638.5A CN201510815638A CN105326651A CN 105326651 A CN105326651 A CN 105326651A CN 201510815638 A CN201510815638 A CN 201510815638A CN 105326651 A CN105326651 A CN 105326651A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Abstract
The invention discloses mouthwash. The mouthwash comprises components in parts by weight as follows: 0.01-10 parts of WS-23 by weight, 0.01-50 parts of menthol by weight, 1-300 parts of a dispersing agent by weight, 0.01-10 parts of a surfactant by weight, 0.01-300 parts of a sweetening agent by weight, 0.5-1 part of a preservative by weight, 0.5-1 part of essence by weight and 800-1000 parts of purified water by weight. A preparation method of the mouthwash comprises steps as follows: the menthol is crushed at the low temperature, and the particle size D90 value is smaller than 380 mu m; menthol powder, WS-23 and polysorbate are added to glycerin, and an oil-phase solution is prepared through stirring; the sweetening agent, the preservative and the essence are added to water and stirred, and an aqueous-phase solution is prepared; the oil-phase solution is added to the aqueous-phase solution, and the mouthwash is obtained through stirring. The mouthwash has the advantages that the cooling feeling can last for a long time and is rich; a fresher and more lasting aroma can be produced; the mouthwash is edible.
Description
[technical field]
The present invention relates to food household chemicals field, specifically relate to a kind of collutory and preparation method thereof.
[background technology]
It is believed that brushes teeth in the past sooner or later just can reach sanitary standard, but can be nowhere near with regard to oral hygiene new concept.Expert proposes: cleaning oral cavity is required as washing one's hands.Gargling is the easy method of oral cavity health most convenient, and it can remove intraoral food debris and the soft dirt of part, temporarily can also reduce the quantity of oral cavity bacterium.Along with the enhancing of people's oral cavity health consciousness, the favor of more and more people can be subject to by the collutory that takes care of one's teeth of fresh breath.Collutory is divided into health and the large class of therapeutic two.The general mouthfeel of health collutory is relatively better, and main component is oral cleansing lotion, for removing halitosis, therefore without the need to special guidance, uses crowd also unrestricted.But therapeutic collutory contains the ingredient of the antiinflammatory such as hibitane, compound iodine preparation, sterilization, cannot at will use.Such collutory can prevention and corntrol periodontal tissue inflammation, so be used in the auxiliary therapy of periodontal disease, oral mucosal disease.
No matter be health or therapeutic type collutory, mouthfeel is all extremely important.Health collutory, mainly plays the effect of fresh breath, higher to the requirement of mouthfeel; If therapeutic collutory mouthfeel is bad, the use of user can be caused to conflict, and then repel use.And the complicated component of the existing collutory commercially sold, general just suggestion spues after gargling, and does not advise eating; In order to reach the effect of the fresh implication of collutory, that compositions by adding multiple freshener increases refrigerant sense, have water miscible in freshener, also have fat-soluble, generally for and better add freshener, add into ethanol in collutory, but the collutory containing ethanol is not suitable for child and driver uses.When not using ethanol in collutory, ensure the stability of the compositions of multiple freshener in collutory, and freshener is a new problem in persistency.
[summary of the invention]
For ensureing the stability of the compositions of multiple freshener in collutory, and freshener is in persistency, the invention provides a kind of collutory, this collutory can significantly improve refrigerant mouthfeel, make oral cavity have lasting salubrious sense, and this collutory all have good stability in a variety of contexts.
The present invention achieves the goal by the following technical programs:
A kind of collutory, is made up of following composition: WS-23:0.01 ~ 10 weight portion, Mentholum: 0.01 ~ 50 weight portion, dispersant: 1 ~ 300 weight portion, surfactant: 0.01 ~ 10 weight portion, sweeting agent: 0.01 ~ 300 weight portion, antiseptic: 0.5 ~ 1 weight portion, essence: 0.5 ~ 1 weight portion, pure water: 800 ~ 1000 weight portions by weight
Preferably, a kind of collutory, is made up of following composition: WS-23:0.1 ~ 10 weight portion, Mentholum: 0.1 ~ 20 weight portion, glycerol: 10 ~ 100 weight portions, Polysorbate: 0.1 ~ 10 weight portion, sweeting agent: 0.1 ~ 50 weight portion, antiseptic: 0.5 ~ 1 weight portion, essence: 0.5 ~ 1 weight portion, pure water: 800 ~ 1000 weight portions by weight.
Described collutory is also containing following parts by weight ingredient: chitosan 10 ~ 40 weight portion.
WS-23 and WS-23 are the good coolant agents of a kind of quality, have higher cool taste activity and do not have the side effect such as calcination, numbness and stimulation, being put in Food Additives Used in China standard GB-2760, can having used safely.
Preferably, described collutory is made up of by weight following composition: WS-23:5 weight portion, Mentholum: 10 weight portions, glycerol: 50 weight portions, Polysorbate: 8 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 850 weight portions.
Preferably, in described collutory composition, dispersant is Oleum Vitis viniferae.
Preferably, also following parts by weight ingredient is contained in described collutory composition: chitosan 10 weight portion.
Preferably, the Polysorbate in described collutory composition can also be any one of sucrose monolaurate, sorbitan ester, polyglycerol stearate, polyoxyethylene sorbitan fatty acid ester, apricot glue or Myrij.
Preferably, the chitosan in described collutory composition can also be hypromellose.
A preparation method for collutory, comprises the steps:
Step 1: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um;
Step 2: Mentholum powder step 1 prepared, adds in glycerol under the condition that WS-23, Polysorbate stir, and fully stirs obtained oil-phase solution;
Step 3: sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
Step 4: join in aqueous phase solution with the linear velocity of 0.4 ~ 1.0m/s by the oil-phase solution prepared, stirs 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtains collutory.
Preferably, described step 3: pure water is heated to 50 ~ 60 DEG C, adds chitosan, be stirred to and dissolve completely, be cooled to room temperature, adds sweeting agent, antiseptic, essence dissolving in pure water and stirs, obtained aqueous phase solution.
Advantage of the present invention is:
(1) collutory of the present invention, use WS-23 and Mentholum combination as freshener, refrigerant sense is sustainable longer, and cool feeling is enriched; Act on whole oral mucosa and throat can produce more pure and fresh, lasting fragrance;
(2) collutory of the present invention, Mentholum powder, WS-23, Polysorbate, add in glycerol and stir, and makes oil phase, then join in aqueous phase, stirring can obtain the collutory of stiff stability, and can the soft zest of refrigerant sense of freshener of enable Mentholum and WS-23 little, effectively prevent the volatilization of WS-23 and Mentholum, be more suitable for popular mouthfeel, be particularly applicable to child and use.
(3) raw material of collutory of the present invention is food stage, and consumer is edible in using when recommended amounts, is safe from harm to health.
(4) in collutory of the present invention, in composition, add chitosan, not only can strengthen the stability of collutory further, the effect of freshener slow release can also be reached, extend the collutory refrigerant sense time in the oral cavity.
(5), in collutory of the present invention, use Oleum Vitis viniferae as dispersant in composition, Oleum Vitis viniferae contains abundant unsaturated fatty acid, mainly oleic acid and linoleic acid, and wherein linoleic content is up to 72% ~ 76%.Oleum Vitis viniferae rich in vitamin E, has stronger non-oxidizability, can effectively extend the shelf shelf-life, not easily causes due to illumination, heat radiation and the oxidative rancidity phenomenon that contacts with air and produce; Penetration is strong, and salubrious non-greasy, very easily by buccal absorption.
[detailed description of the invention]
Below in conjunction with specific embodiment, the invention will be further described:
The investigation of Polysorbate, glycerine input in collutory:
WS-23:5 weight portion, Mentholum: 10 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 1000 weight portions;
By Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, sweeting agent, antiseptic, essence add dissolving in pure water and stir, and stir 30 ~ 50min, obtain base mouthrinse with the speed of 600 ~ 800 turns/min.
Get obtained base mouthrinse, 6 parts of point equivalent, add respectively glycerol to concentration be 0,5,10,20,50,100mg/100ml, test and record the coolant agent persistent period;
Glycerol consumption and coolant agent persistent period relation list
Get obtained base mouthrinse, 7 parts of point equivalent, add respectively Polysorbate to concentration be 0,0.1,5,10,50,100,150mg/100ml, test and record the coolant agent persistent period;
Polysorbate consumption and coolant agent persistent period relation list
The research of mouthwash formula
Take WS-23, Mentholum, Polysorbate, glycerol, sweeting agent, antiseptic, essence, pure water; Prepare by the following method: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add under the condition of WS-23, Polysorbate, stirring in glycerol, fully stir obtained oil-phase solution;
Sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
By the concentration of adjustment WS-23, Polysorbate, glycerol, carry out orthogonal design, investigate the coolant agent persistent period:
The orthogonal of three kinds of components influence factors and experimental result
From experimental result, each factor primary and secondary is arranged as, and glycerol > Polysorbate >WS-23, the optimal level of test is combined as glycerol: 50, Polysorbate: 10, WS-23:6.
Embodiment one:
Take WS-23:0.1 weight portion, Mentholum: 0.1 weight portion, Polysorbate: 0.1 weight portion, glycerol: 10 weight portions, sweeting agent: 100 weight portions, antiseptic: 0.5 weight portion, essence: 1 weight portion, pure water: 800 weight portions;
Preparation: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add in glycerol under the condition that WS-23, Polysorbate stir, fully stir obtained oil-phase solution;
Sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
Embodiment two:
Take WS-23:1 weight portion, Mentholum: 1 weight portion, Polysorbate: 1 weight portion, glycerol: 10 weight portions, sweeting agent: 100 weight portions, antiseptic: 0.5 weight portion, essence: 1 weight portion, pure water: 800 weight portions;
Preparation: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add in glycerol under the condition that WS-23, Polysorbate stir, fully stir obtained oil-phase solution;
Sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
Embodiment three:
WS-23:5 weight portion, Mentholum: 10 weight portions, Polysorbate: 8 weight portions, glycerol: 50 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 850 weight portions;
Preparation: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add in glycerol under the condition that WS-23, Polysorbate stir, fully stir obtained oil-phase solution;
Sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
Embodiment four:
Take WS-23:10 weight portion, Mentholum: 20 weight portions, Polysorbate: 10 weight portions, glycerol: 100 weight portions, sweeting agent: 300 weight portions, antiseptic: 1 weight portion, essence: 0.5 weight portion, pure water: 1000 weight portions;
Preparation: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add in glycerol under the condition that WS-23, Polysorbate stir, fully stir obtained oil-phase solution;
Sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
Embodiment five:
WS-23:5 weight portion, Mentholum: 10 weight portions, Polysorbate: 8 weight portions, glycerol: 50 weight portions, chitosan: 15 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 850 weight portions;
Preparation: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add in glycerol under the condition that WS-23, Polysorbate stir, fully stir obtained oil-phase solution;
Pure water is heated to 50 ~ 60 DEG C, adds chitosan, be stirred to and dissolve completely, be cooled to room temperature, sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
Embodiment six:
WS-23:5 weight portion, Mentholum: 10 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 850 weight portions;
WS-23, Mentholum, fructose, antiseptic, essence are joined in pure water, stirs.
Embodiment seven:
WS-23:5 weight portion, Mentholum: 10 weight portions, Polysorbate: 8 weight portions, Oleum Vitis viniferae: 50 weight portions, chitosan: 15 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 850 weight portions;
Preparation: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um; By the Mentholum powder of preparation, add in Oleum Vitis viniferae under the condition that WS-23, Polysorbate stir, fully stir obtained oil-phase solution;
Pure water is heated to 50 ~ 60 DEG C, adds chitosan, be stirred to and dissolve completely, be cooled to room temperature, sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
The oil-phase solution prepared slowly is added in the aqueous phase solution in stirring, control line speed 0.4 ~ 1.0m/s, stir 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtain collutory.
Refrigerant mouthfeel persistent period test experiments:
Get seven kinds of collutorys in above-mentioned seven embodiments respectively, be numbered 1. number-7. number collutory respectively, 100 consumers are asked to try out four kinds of collutorys at random, according to the experience of consumer, record the persistent period of refrigerant mouthfeel, wherein 1. number average duration 3.1min, 2. number 3.5min, 3. number 27.3min, 4. number 28.5min, 5. number 29.6min, 6. number 3.1min, 7. number 29.1min; By contrasting the persistent period that three kinds of collutorys add glycerol, Polysorbate significantly can increase refrigerant mouthfeel that can draw in embodiment two, three, four; Embodiment five on the basis adding glycerol, Polysorbate, then adds the persistent period that chitosan can increase refrigerant mouthfeel further; Embodiment five is compared with embodiment seven, and use Oleum Vitis viniferae to replace glycerol, the persistent period of refrigerant mouthfeel is long, and the refrigerant sense that experimenter experiences is stronger.
Refrigerant sensory test experiment:
Get above-described embodiment one, two, three, four respectively, five kinds of collutorys in five, respectively 1. number, 2. number, 3. number, 4. number, 5. number reference numeral be, asks 100 consumers try out three kinds of collutorys at random, a kind of collutory that selection mouthfeel of voting is best; 3. number record mouthfeel evaluation, wherein 1. number 15 tickets, 2. number 21 tickets, 3. number 52 tickets, 4. number 27 tickets, 5. number 58 tickets, can obtain and the mouthfeel of 5. number collutory is that Geng Duo consumer is liked.
Stability experiment:
Get five kinds of collutorys in above-mentioned five embodiments respectively, be numbered 1. number-7. number collutory respectively, often kind of collutory samples five parts, four increment product sealings are placed on 4 DEG C, room temperature, keep sample 1 week under the temperature conditions of 40 DEG C, 60 DEG C, the uncovered placement of a sample keeps sample one week, at ambient temperature by observing the stability whether collutory is investigated in layering;
Outcome record is as follows:
It is to be noted all embodiments be all did repeatedly repeat experiment in, with the weight portion replacement Polysorbate such as carrying out by any one of sucrose monolaurate, sorbitan ester, polyglycerol stearate, polyoxyethylene sorbitan fatty acid ester, apricot glue or Myrij respectively in repeating to test, same method prepares collutory, the collutory of preparation uses the collutory of Polysorbate the same in persistent period of refrigerant mouthfeel, sensory test effects fundamental sum, and stability experiment does not all occur lamination.
Usually replace chitosan with hypromellose, prepare collutory by embodiment five, the collutory of preparation uses the collutory of chitosan the same in persistent period of refrigerant mouthfeel, sensory test effects fundamental sum, and stability experiment does not all occur lamination.
Claims (9)
1. a collutory, is characterized in that: described collutory is made up of by weight following composition: WS-23:0.01 ~ 10 weight portion, Mentholum: 0.01 ~ 50 weight portion, dispersant: 1 ~ 300 weight portion, surfactant: 0.01 ~ 10 weight portion, sweeting agent: 0.01 ~ 300 weight portion, antiseptic: 0.5 ~ 1 weight portion, essence: 0.5 ~ 1 weight portion, pure water: 800 ~ 1000 weight portions.
2. collutory as claimed in claim 1, it is characterized in that, described collutory is made up of by weight following composition: WS-23:0.1 ~ 10 weight portion, Mentholum: 0.1 ~ 20 weight portion, glycerol: 10 ~ 100 weight portions, Polysorbate: 0.1 ~ 10 weight portion, sweeting agent: 0.1 ~ 50 weight portion, antiseptic: 0.5 ~ 1 weight portion, essence: 0.5 ~ 1 weight portion, pure water: 800 ~ 1000 weight portions.
3. collutory as claimed in claim 2, is characterized in that: also containing following parts by weight ingredient in described collutory composition: chitosan 10 ~ 40 weight portion.
4. collutory as claimed in claim 2, is characterized in that: described collutory is made up of by weight following composition: WS-23:5 weight portion, Mentholum: 10 weight portions, glycerol: 50 weight portions, Polysorbate: 8 weight portions, sweeting agent: 30 weight portions, antiseptic: 0.6 weight portion, essence: 0.8 weight portion, pure water: 850 weight portions.
5. collutory as claimed in claim 4, is characterized in that: also containing following parts by weight ingredient in described collutory composition: chitosan 10 weight portion.
6. collutory as claimed in claim 1, is characterized in that: described surfactant is any one of sucrose monolaurate, sorbitan ester, polyglycerol stearate, polyoxyethylene sorbitan fatty acid ester, apricot glue or Myrij.
7. collutory as claimed in claim 3, is characterized in that: described chitosan can be hypromellose.
8. a preparation method for collutory, is characterized in that: comprise the steps:
Step 1: by Mentholum pulverize at low temperature, pulverize temperature not higher than 35 DEG C, Mentholum is crushed to particle diameter D90 value and is less than 380um;
Step 2: Mentholum powder step 1 prepared, adds in glycerol under the condition that WS-23, Polysorbate stir, and fully stirs obtained oil-phase solution;
Step 3: sweeting agent, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution;
Step 4: join in aqueous phase solution with the linear velocity of 0.4 ~ 1.0m/s by the oil-phase solution prepared, stirs 30 ~ 50min with the speed of 600 ~ 800 turns/min, obtains collutory.
9. preparation method as claimed in claim 7, is characterized in that: described step 3: pure water is heated to 50 ~ 60 DEG C, adds chitosan, be stirred to and dissolve completely, be cooled to room temperature, sweeting agent, dispersant, antiseptic, essence are added dissolving in pure water and stir, obtained aqueous phase solution.
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| CN201510815638.5A CN105326651B (en) | 2015-06-27 | 2015-11-20 | A kind of mouthwash and preparation method thereof |
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| CN201510367089.XA CN104983595A (en) | 2015-06-27 | 2015-06-27 | Mouth wash and preparation method thereof |
| CN201510367089X | 2015-06-27 | ||
| CN201510815638.5A CN105326651B (en) | 2015-06-27 | 2015-11-20 | A kind of mouthwash and preparation method thereof |
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| CN105326651B CN105326651B (en) | 2018-06-08 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN106726691A (en) * | 2016-12-30 | 2017-05-31 | 泉州亚林新材料科技有限公司 | A kind of shitosan mouthwash and preparation method thereof |
| CN110638672A (en) * | 2019-09-16 | 2020-01-03 | 陈秋迎 | Mouthwash for oral examination or treatment |
| CN111166711A (en) * | 2020-03-05 | 2020-05-19 | 珠海市尼诺生物科技有限公司 | Sterilizing mouthwash |
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| CN104983595A (en) * | 2015-06-27 | 2015-10-21 | 合肥九研医药科技开发有限公司 | Mouth wash and preparation method thereof |
| CN109310587A (en) * | 2016-04-28 | 2019-02-05 | 加利福尼亚大学董事会 | For controlling the composition of bacterial plaque formation |
| CN107449856A (en) * | 2017-09-12 | 2017-12-08 | 国网天津市电力公司电力科学研究院 | The titration method of dodecyl benzyl dimethyl ammonium chloride content in a kind of water |
| CN107648130A (en) * | 2017-11-17 | 2018-02-02 | 蚌埠崇迪生物科技有限公司 | A kind of anti-inflammation gargle water and preparation method thereof |
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| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN106726691A (en) * | 2016-12-30 | 2017-05-31 | 泉州亚林新材料科技有限公司 | A kind of shitosan mouthwash and preparation method thereof |
| CN110638672A (en) * | 2019-09-16 | 2020-01-03 | 陈秋迎 | Mouthwash for oral examination or treatment |
| CN111166711A (en) * | 2020-03-05 | 2020-05-19 | 珠海市尼诺生物科技有限公司 | Sterilizing mouthwash |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105326651B (en) | 2018-06-08 |
| CN104983595A (en) | 2015-10-21 |
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