CN106510896A - Artificial cerebral dura mater - Google Patents
Artificial cerebral dura mater Download PDFInfo
- Publication number
- CN106510896A CN106510896A CN201611109096.0A CN201611109096A CN106510896A CN 106510896 A CN106510896 A CN 106510896A CN 201611109096 A CN201611109096 A CN 201611109096A CN 106510896 A CN106510896 A CN 106510896A
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- CN
- China
- Prior art keywords
- dura mater
- artificial dura
- artificial
- lasso trick
- diaphragm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
Abstract
The invention discloses an artificial cerebral dura mater for tightly mending intraoperative dural injury; the inner surface of the artificial cerebral dura mater is in contact with cerebral tissues, is smooth and is not in adhesion with arachnoid and cerebral tissues; the outer surface of the artificial cerebral dura mater is provided with a plurality of loops (1) for surgical sewing. It is very convenient to perform sewing during surgery, sewing is easy, post-sewing watertightness is good, the artificial cerebral dura mater is simple to operate and is smooth after being fixed, and the watertightness problem of existing artificial cerebral dura mater in use is solved.
Description
Technical field
The present invention relates to medical operating technical field；More particularly to used in a kind of neurosurgery or department of cerebral surgery prosthesis
Artificial dura mater.
Background technology
Easily there is dura defect or situation about tightly cannot repair in many operation, " cerebrospinal leak " just occur,
Even cause " intracranial infection ", consequence is very serious.So the operation of brain and spinal cord requires tightly suture dura mater, rebuild
Its watertightness performance.
Artificial dura mater (Artificial Dura Mater) is exactly autologous for repairing with good organization's compatibility
Dura defect, an artificial substitution material for recovering its watertightness." artificial dura mater " is with artificial material or biomaterial system
The substitute of adult body meninges, for the cerebral dura mater that causes because of the damage of cranium brain or spinal cord, tumor and other Cerebral Injuries or ridge
The repairing of film defect, prevents the severe complications such as cerebrospinal fluid leakage, intracranial infection, Naoning tablet, brain adhesion, to recover its integrity
And watertightness.
But current artificial dura mater has many kinds, but all has identical shortcoming --- -- only as one " rubberized fabric ".
Need to be sewn onto on the edge of dura defect with one pin of surgical thread, one pin as suturing " hole of cloth curtain " in operation process,
As dural defect margin is usually irregular, and artificial dura mater is often tougher, penetrated with pin it is relatively difficult, so suture
Difficulty is very big, and cannot " average suture ", i.e., using sealers such as medical adhesives, accomplish " watertightness " suture or it is highly difficult
Something.This is one of difficult problem of maximum of the clinical neurosurgeon of puzzlement at present.
The content of the invention
It is an object of the invention to provide a kind of artificial dura mater, can very easily suture in operation, suture is easy, seam
After conjunction, " watertightness " is good, and after simple to operate, fixation, artificial hard dura mater is smooth, while solving in current artificial dura mater use
Water tightness problems.
The purpose of the present invention is achieved through the following technical solutions：
A kind of artificial dura mater, for the tight repairing of dura defect in operation, described artificial dura mater includes diaphragm
2, the inner surface of diaphragm 2 is contacted with cerebral tissue, and described inner surface is smooth with arachnoidea and cerebral tissue adhesion；Outside diaphragm 2
Surface is provided with multiple lasso tricks 1 for operation stitching.
Described lasso trick 1 is clouded in the outer surface of artificial dura mater.
Described 1 criss-cross arrangement of lasso trick.
Described 1 array of lasso trick is uniformly arranged.
1 ± the 0.5mm of thickness of described diaphragm 2.
1 ± the 0.5mm of height of described lasso trick 1.
The source of the material of described artificial dura mater includes native gold, native silver, stainless steel substrates, rubber membrane, plug road fine jade film, Buddhist nun
Imperial film, poly tetrafluoroethylene, terylene silicone rubber membrane, fibroin protein film, biological collagen substrate glued membrane or bacteria cellulose film；
The source of the material of described artificial dura mater such as includes at the biomaterial such as various artificial materials or bovine pericardium.
As seen from the above technical solution provided by the invention, the artificial dura mater after present invention design, can be in handss
Very easily suture in art, suture is easy, and after suture, " watertightness " is good, it is simple to operate, fixed after artificial hard dura mater it is smooth, solve
The problems such as water tightness problems and big suture difficulty in current artificial dura mater use.
Description of the drawings
In order to be illustrated more clearly that the technical scheme of the embodiment of the present invention, below will be to using needed for embodiment description
Accompanying drawing be briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for this
For the those of ordinary skill in field, on the premise of not paying creative work, can be obtaining other according to these accompanying drawings
Accompanying drawing.
Fig. 1 is the main structure diagram of artificial dura mater provided in an embodiment of the present invention；
Fig. 2 is the left view cross section structure diagram of artificial dura mater provided in an embodiment of the present invention；
Fig. 3 is the A portions mplifying structure schematic diagram with regard to Fig. 1 of artificial dura mater provided in an embodiment of the present invention；
Fig. 4 is the B portions mplifying structure schematic diagram with regard to Fig. 2 of artificial dura mater provided in an embodiment of the present invention.
Specific embodiment
With reference to the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Ground description, it is clear that described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based on this
Inventive embodiment, the every other enforcement obtained under the premise of creative work is not made by those of ordinary skill in the art
Example, belongs to protection scope of the present invention.
The embodiment of the present invention is described in further detail below in conjunction with accompanying drawing.
As best shown in figs. 1 and 4, a kind of artificial dura mater, for the tight repairing of dura defect in operation, described is artificial
Cerebral dura mater includes diaphragm 2, and the inner surface of diaphragm 2 is contacted with cerebral tissue, described inner surface it is smooth with arachnoidea and cerebral tissue not
Adhesion；The outer surface of diaphragm 2 is provided with multiple lasso tricks 1 for operation stitching.Described lasso trick 1 can be clouded in artificial hard brain
The outer surface of film.Edge can also be distributed across, only needing to be sewed with region area's setting to be stapled, this mode is especially suitable
In by " " technology is come the artificial dura mater realized for 3D printing.1 criss-cross arrangement of lasso trick that can be as described in Figure, it is specific vertical
The set annular distance of the lasso trick 1 of row 11, in arranged in parallel, is also arranged in parallel between each row, and the set annular distance of the lasso trick 1 of row 12 is in always
Line word order, it is each arrange between be also arranged in parallel, and each row are respectively separated located between the lasso trick 1 of each file, or, being across lasso trick
Form lasso trick to intersect on 1, in figure, do not represent this scheme.Interval between row minimum is accomplished as far as possible according to the situation of technique.Between lasso trick 1
Interval be less than 1mm, 0.2 to 0.5mm can be accomplished in some cases, it is even more little.
The arrangement of lasso trick 1 can be uniformly arranged with described 1 array of lasso trick.Can be horizontal array can also be circular array.
It can certainly be irregular arrangement.The crisscross distribution of 1 one-tenth of lasso trick, is clouded on artificial dura mater outer surface.For conjunction
Suitable material can be with " " technology is realizing for 3D printing.
In addition, 1 ± the 0.5mm of thickness of described diaphragm 2.1 ± the 0.5mm of height of described lasso trick 1.It is suitable for different years
The different situations of the individual variations such as age, sex, body weight.
The clinical requirement to artificial dura mater is：
1st, it is nontoxic, body and cerebral tissue are had no adverse reaction；
2nd, surface is smooth, with arachnoidea and cerebral tissue adhesion；
3rd, with certain intensity, elasticity and extensibility；
4th, it is easy to sterilize and preserve.
5th, absorbable material can be used.
The material selection of the artificial dura mater of this patent need to meet the requirement of the above with inner surface smooth degree.
Therefore, the artificial dura mater of present patent application possesses following characteristics：
1st, material source is sufficient, and preparation technology is easy；
, there is no meninges-brain adhesion in the 2nd, stable chemical nature, NAI reaction；
3rd, histocompatibility is good, has no toxic side effect, and does not produce immunoreation；
4th, safety is good, non-carcinogenesis material, not transmitted virus disease；
5th, good toughness；
6th, compactness is good, ne-leakage.
So the material for meeting requirements above is protection scope of the present invention, the material of described artificial dura mater can be with
Choose in following material：Including native gold, native silver, stainless steel substrates, rubber membrane, plug road fine jade film, nylon membrane, poly tetrafluoroethylene,
Terylene silicone rubber membrane, fibroin protein film, biological collagen substrate glued membrane or bacteria cellulose film, these artificial materials can pass through 3D
Printing or machining or the technique similar to injection carry out complete design purpose.
The material of described artificial dura mater can be with the selection in following material：Animal fascia or pericardium (such as bovine pericardium)
Deng biomaterial, biomaterial can realize surface treatment by mechanically or physically processing mode.
During use, a piece of artificial dura mater is taken, be cut into suitable shape as needed, or pass through " 3D printing " technology
Print suitable shape.It is laid in below dural defect margin, have lasso trick 1 one faces out, and is passed through with suturess
Knot after the lasso trick 1 of brain dura mater edge and artificial dura mater can it is smooth, easily and efficiently fix artificial dura mater, have
The characteristics of dura mater is smooth after simple to operate, fixed, solves the difficulty of the maximum in current artificial dura mater use.
Above,
Fibroin protein film, fibroin albumen (silk fibroin) is a kind of fibroin.Knot is belonged to together with skin collagen
Structure albumen, its material source enrich, it is easy to process.Kim etc. carries out hard brain to dura defect rat model using fibroin protein film
Film is repaired, and has carried out a series of researchs with regard to its cytotoxicity and antiinflammatory action.As a result show：Fibroin protein film no cytotoxicity,
And the expression of epoxidation synthase -2 (COX-2) and nitric oxide synthase type (iNOS) can be effectively reduced, while reducing scorching
The expression of sexual cell factor IL-1 β, IL-6 and tumor necrosis factor-alpha (TNF-α), without cerebrospinal leak after Rat Dura Mater reparation
Occur.There is scholar that fibroin albumen has been made Static Spinning nanometer fibroin fiber, and to its physicochemical property, the form (fineness of fiber
And porosity), compare and study in terms of structural stability and biocompatibility, it is believed which can be used for tissue repair and again
The biomedical engineering such as raw.Used as a kind of new material, its long-term impact also needs to further verify fibroin protein film, in addition such as
What better controls over its biomechanical property, aperture and porosity, degradation rate etc. is organized what itself repaired to adapt to cerebral dura mater
Require, need more extensively and in depth to probe into.
It is postoperative in reduction vertebrae plate resection that Tao etc. compares lyophilizing amniotic membrane, glutamine crosslinking amniotic membrane and autologous free-fat
Effect in terms of Peridural Adhesion.As a result show：Glutamine crosslinking amniotic membrane can effectively reduce epidural scarring fibrosiss,
Cicatricial adhesion quantity and intensity are reduced, mitigates post-operative complication.Hao etc. is wrapped in amniotic membrane by around cross-section nerve, finds
Which can efficiently reduce the adhesion and the formation of cicatrix of nerve and surrounding tissue, so as to retaining the animal migration of neurocyte and preventing
Only stretch injury and ischemia.Amniotic membrane meets the advantage that dural repairment material should possess at many aspects, is expected to become a kind of
More satisfactory dural repairment material.
Biological collagen substrate glued membrane, collagen (Collagen) belong to fibrous proteins family, are zooblast epimatrixs
With the main component of connective tissue.The type of collagen is a lot, wherein I type is most commonly seen, is present in the portions such as skin, skeleton, tendon
Position, molecule are elongated, have rigidity, by 3 collagen polypeptide chain formation triple-helix structures.TissuDura is a kind of from the extraction of horse heel string
Collagen protein colloid, Jing sodium hydroxide and concentrated hydrochloric acid inactivation treatment, the incidence rate without whole body and local toxicity, adhesion and infection
It is extremely low.Pettorini etc. applies TissuDura as dura mater substitution material in 47 pediatric neurosurgery operations, as a result shows
Show which can effectively prevent and treat cerebrospinal leak and NIP reaction and postoperative infection.Ciro etc. is being used for the one of cerebral dura mater reparation to which
The long-term iconography of item and neuro pathology are thought in evaluating:TissuDura high resiliences, chemical inertness are strong, and adaptability is good, together
When it is simple, convenient and rapid in using method.With without the need for suturess, also not observing during this Fibrin Glue Hard meninges in reconstruction
The generation of the complication such as cerebrospinal leak, adhesion and infection.Additionally, because Fibrin Glue soverlay technique is simple, can be effective
Shorten the time of operation, while with certain transparency, be conducive to the inspection in operation technique region, so as to reduce operation wind
Danger.
Bacteria cellulose film, Bacterial cellulose (Bacterial cellulose, BC) are in acetobacter fermentation culture mistake
The cellulose synthesized by acetobacter in journey, with the netted structure of exquisite natural fiber being made up of ultra-microfibers, BC diameters are only
For 10nm～80nm, belong to nano-scale fiber, be natural fiber most thin at present.Bacterial cellulose has the property of many uniquenesses,
Such as high-crystallinity and high chemical purity, high-tensile and elastic modelling quantity, very strong water associativity, splendid shape maintain ability
With anti-tear power, higher biocompatibility and good biological degradability, and, Bacterial cellulose its performance in biosynthesiss
There is Modulatory character with shape, i.e., by adjusting condition of culture, the discrepant Bacterial cellulose of physics, chemical property is obtained
Film.These features make Bacterial cellulose be widely used at aspects such as food, medicine, chemical industry.It is made up of Bacterial cellulose
Dressing such as Biofil and Bioprocess etc. have good therapeutical effect to skin burn, in Countries commercialization.
Bacteria cellulose film is with many potential excellent condition as artificial dura mater.Sanchez e Oliveira
Rde etc. is compared to the repairing treatment that BC is applied to fetal lamb Myelomeningocele disease with people's acellular dermal matrix, as a result
Show:BC can more fully cover damaged nerve tissue, not depend on surface and the deep layer of nervous tissue, so as to reduce to spinal cord
Machinery and chemical damage.BC also has more advantage in cardia and in terms of avoiding nervous tissue's adhesion.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, the change or replacement that can be readily occurred in,
Should all be included within the scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Enclose and be defined.
Claims (8)
1. a kind of artificial dura mater, for the tight repairing of dura defect in operation, it is characterised in that described artificial dura mater
Including diaphragm (2), the inner surface of diaphragm (2) is contacted with cerebral tissue, and described inner surface is smooth not to be glued with arachnoidea and cerebral tissue
Even；The outer surface of diaphragm (2) is provided with multiple lasso tricks (1) for operation stitching.
2. artificial dura mater according to claim 1, it is characterised in that described lasso trick (1) is clouded in artificial dura mater
Outer surface, or, lasso trick (1) is distributed in the area to be stapled at artificial dura mater edge.
3. artificial dura mater according to claim 2, it is characterised in that described lasso trick (1) criss-cross arrangement.
4. artificial dura mater according to claim 2, it is characterised in that described lasso trick (1) array is uniformly arranged.
5. the artificial dura mater according to claim 1,2,3 or 4, it is characterised in that the thickness 1 of described diaphragm (2) ±
0.5mm。
6. artificial dura mater according to claim 5, it is characterised in that the 1 ± 0.5mm of height of described lasso trick (1).
7. the artificial dura mater according to claim 1,2,3 or 4, it is characterised in that the material of described artificial dura mater
Including native gold, native silver, stainless steel substrates, rubber membrane, plug road fine jade film, nylon membrane, poly tetrafluoroethylene, terylene silicone rubber membrane, fibroin
Albuminous coat, biological collagen substrate glued membrane or bacteria cellulose film.
8. the artificial dura mater according to claim 1,2,3 or 4, it is characterised in that the material of described artificial dura mater
Including animal fascia or pericardium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611109096.0A CN106510896A (en) | 2016-12-06 | 2016-12-06 | Artificial cerebral dura mater |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611109096.0A CN106510896A (en) | 2016-12-06 | 2016-12-06 | Artificial cerebral dura mater |
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| CN106510896A true CN106510896A (en) | 2017-03-22 |
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| CN201611109096.0A Pending CN106510896A (en) | 2016-12-06 | 2016-12-06 | Artificial cerebral dura mater |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972060A (en) * | 2021-02-04 | 2021-06-18 | 华东医院 | Device for preventing tissue adhesion in operation area after craniotomy in neurosurgery |
| CN113805294A (en) * | 2021-08-30 | 2021-12-17 | 富通集团（嘉善）通信技术有限公司 | Resistance to compression optical cable |
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| CN101507661A (en) * | 2009-03-10 | 2009-08-19 | 广州迈普再生医学科技有限公司 | Nano artificial dura mater with multi functional-layers and preparation method thereof |
| CN202568329U (en) * | 2012-08-10 | 2012-12-05 | 王铭 | Repairing device for cerebrospinal rhinorrhea with transnasal approach |
| CN103220998A (en) * | 2010-10-06 | 2013-07-24 | Ams研究公司 | Implants with absorbable and non-bsorbable features for the treatment of female pelvic conditions |
| CN103800097A (en) * | 2012-11-14 | 2014-05-21 | 深圳迈普再生医学科技有限公司 | Fibrous membrane for tissue repair and manufacturing method and application thereof |
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5634944A (en) * | 1995-02-23 | 1997-06-03 | The Nemours Foundation | Body membrane prosthesis |
| US20030204270A1 (en) * | 2002-04-25 | 2003-10-30 | Berman Andrew B. | Membrane for use in sutured or sutureless surgical procedures |
| CN1972644A (en) * | 2003-11-21 | 2007-05-30 | 骨棚国际私人有限公司 | Bioabsorbable plug implants and method for bone tissue regeneration |
| US20050124990A1 (en) * | 2003-12-09 | 2005-06-09 | Michael Teague | Bone plate holder and screw guide |
| CN101507661A (en) * | 2009-03-10 | 2009-08-19 | 广州迈普再生医学科技有限公司 | Nano artificial dura mater with multi functional-layers and preparation method thereof |
| CN103220998A (en) * | 2010-10-06 | 2013-07-24 | Ams研究公司 | Implants with absorbable and non-bsorbable features for the treatment of female pelvic conditions |
| CN202568329U (en) * | 2012-08-10 | 2012-12-05 | 王铭 | Repairing device for cerebrospinal rhinorrhea with transnasal approach |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972060A (en) * | 2021-02-04 | 2021-06-18 | 华东医院 | Device for preventing tissue adhesion in operation area after craniotomy in neurosurgery |
| CN112972060B (en) * | 2021-02-04 | 2023-07-14 | 华东医院 | Device for preventing operation area from blocking after craniotomy in neurosurgery |
| CN113805294A (en) * | 2021-08-30 | 2021-12-17 | 富通集团（嘉善）通信技术有限公司 | Resistance to compression optical cable |
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Application publication date: 20170322 |