CN1092314A - Treatment diarrheal Chinese medicine for outer use - Google Patents

Abstract

A kind of treatment diarrheal Chinese medicine for outer use---diarrhoea one is pasted spirit, is to select compatibility from Poria 5～25%, Cortex Cinnamomi 5～25%, Fructus Evodiae 5～20%, Flos Caryophylli 5～25%, Fructus Foeniculi 5～25%, Radix orixae japonicae 5～15%, Rhizoma Atractylodis 5～25%, Fructus Amomi 5～15%, Pericarpium Citri Reticulatae 5～15%, the Radix Aucklandiae 5～20%, Radix codonopsis pilosulae 5～20%, Rhizoma Coptidis 5～25%, the Rhizoma Atractylodis Macrocephalae 5～20% and Radix Sophorae Flavescentis 10～20%.Dosage form can be rubber-emplastrum or powder.Stick in SHENQUE acupoint.Treat all kinds of diarrhoea, enterospasm and dysentery, antidiarrheal, pain relieving fast, convenient, safe, inexpensive.

Description

Treatment diarrheal Chinese medicine for outer use

The present invention relates to a kind of new treatment diarrheal pharmaceutical preparation, the novel therapeutic diarrheal Chinese medicine for outer use that particularly a kind of pure drug matching, prescription form-diarrhoea one is pasted spirit.

The diarrheal cause of disease, doctor trained in Western medicine are divided into infectious or non-infectious, and its treatment means is antibiotic to use, the antibiotic of antiinflammatory, or oral or muscle or intravenously administrable, and certain curative effect is arranged, but its deficiency is not only or high price or the course of treatment are long; And studies show that in recent years, the abuse of broad ectrum antibiotic has produced Drug resistance, toxic and side effects, even causes drug-induced disease.

Chinese traditional treatment diarrheal method, be to the patient take Chinese herbs decoction or Chinese patent medicine ball, to loose be main, its defective is the time-consuming bitter in the mouth of decoct, and Chinese patent medicine ball, the produce effects of loosing are slower.

Especially infant patient is oral or drug administration by injection difficulty relatively all, and the infantile diarrhea rotavirus cause account for 80%, doctor trained in Western medicine does not have the specially good effect safe drugs.

Purpose of the present invention, be exactly according to traditional Chinese medical theory and experience, excavate the natural resources of Chinese medicinal materials of motherland's preciousness, develop a kind of inner disease outer treat means that combine together with meridians effect and drug influence, be various acute and chronic diarrhoea, especially the Chinese medicine reasonable compatibility prescription that the infant patient is suitable for, inexpensive, no pain, produce effects is fast, curative effect is high, the novel formulation that has no side effect.

Task of the present invention is implemented with following technical scheme:

A kind of treatment diarrheal of development and design Chinese medicine for outer use is characterized in that:

1. be pure Chinese medicinal preparation,

2. used medical material is selected compatibility, prescription from comprise flavors such as Poria, Cortex Cinnamomi, Fructus Evodiae, Flos Caryophylli, Fructus Foeniculi, BAIHU Fructus Foeniculi, Radix orixae japonicae, Rhizoma Atractylodis, Fructus Amomi, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Radix codonopsis pilosulae, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae and Radix Sophorae Flavescentis.

Above-mentioned diarrhoea one is pasted spirit, and when described compatibility, prescription, the part by weight of each medical material can be:

Poria 5～25%, Cortex Cinnamomi 5～25%, Fructus Evodiae 5～20%, Flos Caryophylli 5～25%, Fructus Foeniculi 5～25%, Radix orixae japonicae 5～15%, Rhizoma Atractylodis 5～25%, Fructus Amomi 5～15%, Pericarpium Citri Reticulatae 5～15%, the Radix Aucklandiae 5～20%, Radix codonopsis pilosulae 5～20%, Rhizoma Coptidis 5～25%, the Rhizoma Atractylodis Macrocephalae 5～20% and Radix Sophorae Flavescentis 10～20%.

Above-mentioned diarrhoea one is pasted spirit, and its dosage form can be rubber-emplastrum or powder.

Above-mentioned diarrhoea one is pasted spirit, and sticking the position is SHENQUE acupoint.

After the preliminary election routinely respectively of above-mentioned each Chinese crude drug, roguing, former medicated powder is broken, sieve or through extract, remove slag, concentrate, behind the precipitate with ethanol, compatibility is pressed the powder of Chinese Pharmacopoeia rules of preparations regulation respectively by a certain percentage, and the process of preparing Chinese medicine of dosage forms such as plaster or rubber-emplastrum requires to concoct.

Diarrheal mechanism is mainly blamed in taste, and weakness of the spleen and stomach further develops and can cause hypoactivity of spleen-YANG, the defeated cloth of fortuneization precise and tiny, and it is few to decline day by day, and kidney yang vital essence source lacks, insufficiency of kidney-YANG, decline of the fire from the gate of life, and yang-energy made us watery diarrhea and forms diarrhoea incessantly in the highest.

SHENQUE acupoint is important acupuncture point on the conception vessel, and is corresponding with governor vessel, the gate of vitality, appoints to superintend and direct through gas phase logically, and coordination of YIN and YANG plays the physiological function of regulating internal organs, and umbilicus is the congenital root base of a fruit that invests life, is arranged in Jiao, the acquired disease of supervising the cooking.

The herbal application umbilical part, but all thick Chinese medicine of nationality abnormal smells from the patient excites the acupuncture points on the human body function, so easily produce drug effect, forms higher drug level and defeated cloth whole body at abdominal part, adjusts internal organs disease of ZANG-organs reason state, and plays whole therapeutical effect.

Use " diarrhoea one is pasted spirit ", sticking in SHENQUE acupoint is the unique therapy of inner disease outer treat that meridians effect and drug influence combine together, to the many types of acute and chronic diarrhoea of the traditional Chinese medical science, quick anti-diarrhea effect is arranged all.

Toxicity, sensitization test (STT) have been done via Qingdao Medical College, skin injury and bacteriostatic test.

Toxicological test shows, program is according to the rules carried out, and diarrhoea one is pasted the principal agent of spirit, and is up to specification to the acute toxicity test of white mice, the subacute toxicity result of study, diarrhoea one is pasted clever principal agent does not have obvious harmful effect to rat routine blood test, liver function, kidney merit and main organs.

The toxicity that diarrhoea one subsides spirit is described is low, safety is big.

Sensitization test (STT) and skin injury result of the test, it is non-stimulated to skin that diarrhoea one is pasted spirit, not damaged.

Bacteriostatic test result, diarrhoea one paste spirit staphylococcus aureus, Escherichia coli, Candida albicans etc. are caused the common flora of diarrheal, and stronger inhibitory action is all arranged.

Medicine of the present invention not only has the function of function of spleen and stomach regulating, relieving spasm to stop pain, also has antiviral and stronger bacteriostasis.

Clinically be used for the treatment of example surplus the infantile viral enteritis 2000, total effective rate 97%, some cases add pipemidic acid with virazole and compare medication, and the result is as follows:

Diarrhoea one is pasted clever papova azoles and is added the pipemidic acid group

Effective 2% 20%

Produce effects 95% 30%

Total effective 97% 50%

Invalid 3% 50%

The Western medicine virazole that " diarrhoea one is pasted spirit " group obviously is better than contrasting adds the pipemidic acid group.

Facts have proved that the one subsides spirit of treatment diarrheal pharmaceutical preparation diarrhoea has following advantage:

1. quick-acting, acute diarrhea is cured with back 6～12h produce effects, general 24h; The chronic diarrhea curative effect also be better than existing in, the western drug preparation; The clinical verification cure rate reaches 97%.

2. convenient, inner disease outer treat sticks " diarrhoea one is pasted spirit " in SHENQUE acupoint to be umbilicus, to need not to have an injection and take medicine that no pain gets final product produce effects.

3. safety, toxicity, sensitization, skin and bacteriostatic test through system prove safe without toxic side effect.

4. inexpensive, mean treatment one routine diarrhea patient only needs medication 1～2 time, and 5～10 yuan of expenses than the doctor trained in Western medicine antibiotherapy of routine, save 80～90%.

Market prospect is wide, and according to the retrieval at present both at home and abroad to treating acute and chronic enteritis, Shang Weijian is so quick-acting, medicine easily.

Be not only applicable to various acute and chronic diarrhoea, infantile viral enteritis also can be used for illness such as enterospasm, dysentery, and quick antidiarrheal, analgesic effect are arranged.

Being specially adapted to the inconvenient occasion of having an injection, take medicine, is traveller, sea and field work personnel, frontier defense soldier's etc. indispensable good medicine.

Social benefit and remarkable in economical benefits have reached intended purposes of the present invention preferably.

The present invention is further elaborated below in conjunction with embodiment:

[embodiment one] preparation " diarrhoea one paste spirit " powder, in following ratio compatibility:

Poria 25%, Radix orixae japonicae 5%, Rhizoma Atractylodis 20%, Pericarpium Citri Reticulatae 5%, the Radix Aucklandiae 20%, Rhizoma Coptidis 5% and Radix Sophorae Flavescentis 20%.

Technical process:

The above-mentioned batch of all medical material of dosage, conventional drying are to moisture content≤5%, and fusion also is crushed to fine powder, cross 100 mesh sieves, low temperature sterilization, and packing is divided two kinds, and it is a bag that children's packs every 0.1g; The every 0.3g of adult's packing is a bag.

Check projects such as the uniformity, moisture content, content uniformity qualified by the pharmacopeia requirement after, warehouse-in.

Usage, consumption

Be used for the treatment of infantile diarrhea, once measure children's and pack 1～3 bag; Be used for the treatment of adult diarrhea, once amount adult packing 1～3 bag.All be to stick in SHENQUE acupoint with adhesive plaster, 24h changes dressings once.

[embodiment two] preparations " diarrhoea one paste spirit " rubber plaster, in following ratio compatibility:

Poria 5%, Cortex Cinnamomi 25%, Flos Caryophylli 5%, Radix orixae japonicae 15%, Pericarpium Citri Reticulatae 15%, Radix codonopsis pilosulae 20%, the Rhizoma Atractylodis Macrocephalae 5% and Radix Sophorae Flavescentis 10%.

Technical process:

1. Chinese crude drug is made fine powder or medicinal extractum with example one;

2. use substrate, softening agent, thickening agent and the filler of pharmacopeia regulation;

3. be coated with " mixing " operation adding drug extract of exhibition method, substrate, softening agent, thickening agent and the filler etc. of pharmacopeia regulation in hot pressing, by conventional method refine, the gluing of pharmacopeia regulation, section;

4. by projects such as pharmacopeia requirement check outward appearance, paste containing amount, heat resistant tests;

5. qualified back packing.

Usage, consumption

Be used for the treatment of infantile diarrhea, (be equivalent to principal agent 30～35mg), 12h changes dressings once once to pack 1 with children's; Be used for the treatment of adult diarrhea, (be equivalent to principal agent 35～40mg), 6h changes dressings once, all is to stick in SHENQUE acupoint once to pack 1 with the adult.

[embodiment three] preparations " diarrhoea one paste spirit " powder, in following ratio compatibility:

Poria 5%, Fructus Evodiae 20%, Fructus Foeniculi 25%, Rhizoma Atractylodis 5%, Pericarpium Citri Reticulatae 5%, the Radix Aucklandiae 20% and the Rhizoma Atractylodis Macrocephalae 20%.

Technology, condition, usage, consumption etc. are all with embodiment one.

[embodiment four] preparations " diarrhoea one paste spirit " rubber-emplastrum, in following ratio compatibility:

Cortex Cinnamomi 5%, Fructus Evodiae 5%, Flos Caryophylli 25%, Fructus Foeniculi 5%, Rhizoma Atractylodis 25%, Fructus Amomi 5%, Pericarpium Citri Reticulatae 5% and Rhizoma Coptidis 25%.

All the other are all with embodiment two.

[embodiment five] preparations " diarrhoea one paste spirit " rubber plaster, in following ratio compatibility:

Poria 25%, Fructus Evodiae 10%, Fructus Foeniculi 5%, Rhizoma Atractylodis 5%, Fructus Amomi 15%, Pericarpium Citri Reticulatae 5%, the Radix Aucklandiae 5%, Radix codonopsis pilosulae 5%, the Rhizoma Atractylodis Macrocephalae 20% and Cortex Cinnamomi 5%.

All the other are all with embodiment two.

Claims (4)

1, a kind of treatment diarrheal Chinese medicine for outer use, feature of the present invention is:

1.1 be pure Chinese medicinal preparation,

1.2 used medical material is selected compatibility, prescription from comprise flavors such as Poria, Cortex Cinnamomi, Fructus Evodiae, Flos Caryophylli, Fructus Foeniculi, Radix orixae japonicae, Rhizoma Atractylodis, Fructus Amomi, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Radix codonopsis pilosulae, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae and Radix Sophorae Flavescentis.

2, treatment diarrheal Chinese medicine for outer use according to claim 1, when it is characterized in that described compatibility, prescription, the part by weight of each medical material can be:

Poria 5～25%, Cortex Cinnamomi 5～25%, Fructus Evodiae 5～20%, Flos Caryophylli 5～25%, Fructus Foeniculi 5～25%, Radix orixae japonicae 5～15%, Rhizoma Atractylodis 5～25%, Fructus Amomi 5～15%, Pericarpium Citri Reticulatae 5～15%, the Radix Aucklandiae 5～20%, Radix codonopsis pilosulae 5～20%, Rhizoma Coptidis 5～25%, the Rhizoma Atractylodis Macrocephalae 5～20% and Radix Sophorae Flavescentis 10～20%.

3, treatment diarrheal Chinese medicine for outer use according to claim 1 is characterized in that its dosage form can be rubber-emplastrum or powder.

4, treatment diarrheal Chinese medicine for outer use according to claim 1 is characterized in that application site is a SHENQUE acupoint.