CN1112438A

CN1112438A - Chinese medicine compound hematic tonic liniment and its preparing method

Info

Publication number: CN1112438A
Application number: CN 95103710
Authority: CN
Inventors: 胡英姿; 曾永保
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-04-12
Filing date: 1995-04-12
Publication date: 1995-11-29

Abstract

The medicinal liquid for external use is prepared from a small amount of arsenide and Chinese angelica, stem of spatholobus, codonopsis pilosula, root of astragalus membranaceus, pseudo-ginseng, soap vitriol, blue vitriol, antioxidizing agent, preservative and skin osmosis promoter, and is spread on the skin and capable of preventing and treating anemia and diseases caused by deficiency of the vital energy and the blood.

Description

Chinese medicine compound hematic tonic liniment and its preparing method

The present invention relates to a kind of prevention and treatment human body or the Chinese medicine preparation of diseases such as mammal anemia, deficiency of both QI and blood and production method of this preparation that absorbs through skin.

Anemia is the commonly encountered diseases of human body and animal, and its symptom is weak, and resistance is poor, if infant or children mammal in age, health was poor when getting anemia, hypoevolutism, mental retardation, very easy other disease that causes, treat this disease and mainly be at present the injection of oral medicine and injection, and inject pretty troublesomely, oral medicine is to some people curative effect and not obvious, particularly some child is reluctant to take medicine and have an injection.For children mammal in age, because the foodstuff beyond the breast milk of still can oneself not looking for food generally also is difficult to irritate feed.Relevant by retrieval data and document also can not made in vigorous health dose open report again about utilizing the Chinese medicine compound liniment to do prevention and treatment human body or animal anemia agent medicine at present.

The purpose of this invention is to provide and a kind ofly utilize some Chinese medicine, mineral and other to promote additive combination after be coated with and put the medicinal liquid that just can reach prophylactic treatment anemia and the said deficiency of both QI and blood of theory of Chinese medical science on human body or mammal skin surface on the skin.

Medicinal liquid of the present invention mainly comprises a spot of arsenic compound, have the synthesis material copper sulfate of some Chinese medicine of blood yiqi effect, hemoglobin and ferrous sulfate and antioxidant, the material of complexing of metal ion agent, anticorrosion system, surfactant, also should add dermal osmosis accelerator, cooperatively interact by these materials, it is reached is easily absorbed by skin surface, stimulate the effect of human body or mammal hematopoietic function, strengthening body, below introduce composition, content and the compound method of medicinal liquid respectively:

One, arsenic compound

The present invention is chosen at the arsenic compound of Chinese medicine safe level as main liquid (I), and the material of being got can be chosen any one kind of them in following compounds: (1) arsenic sulfide AsS, (2) arsenic trioxide As ₂O ₃, (3) arsenite (KAsO, NaAsO), (4) atoxylic acid (arsanilic acid) and salt thereof, (5) contain the chemical compound (as ferric methylarsonate, sodium methylarsonate, sodium dimethyl arsine etc.) of methanearsonic acid.

Above-mentioned inorganic arsenic needs it is dissolved in small amounts of sodium hydroxide or the potassium hydroxide solution before use, and organo-arsenic is dissolved in polar organic solvent such as dimethyl sulfoxide, N, and dinethylformamide etc. add a small amount of distilled water diluting again, and are standby.Its concentration is the 0.01-2% of total dose, the weight (gram) in promptly per 100 milliliters of total medicinal liquids, and preferred concentration 0.3-0.5%, this solution are main liquid (I).

Two, Chinese medicine part (pressing the title of Chinese medicine handbook):

(1) optional 1-3 kind or whole in Radix Angelicae Sinensis, Caulis Spatholobi, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, the Radix Paeoniae Alba.

(2) optional 1-3 kind or all in the middle of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Radix Notoginseng, Radix Glycyrrhizae, its content contains crude drug weight and accounts for medicinal liquid gross weight (100 milliliters) to amount to, and every kind of Chinese medicine that is selected into is generally 10-80%.

Above-mentioned Chinese medicine generally need extract its active ingredient with separating out alcohol method, decocting method or the way of distillation, and is standby, and this solution is main liquid (II).

Three, Melanteritum and Chalcanthitum, Melanteritum are FeSO ₄7H ₂O, Chalcanthitum are CuSO ₄5H ₂O, the use amount of Melanteritum is the 20-45% of total amount of liquid medicine, (the total amount of liquid medicine of g/100ml), the optimum consumption is 30-40%, the consumption of Chalcanthitum is 2-20%, and the optimum consumption is 5-10%, and Melanteritum and Chalcanthitum add the mode of medicinal liquid for being dissolved in an amount of distilled water, filter the back and merge with the main liquid that above-mentioned Chinese medicine makes, standby.

Four, antioxidant, complexing of metal ion agent, antiseptic, surfactant, selected antioxidant is ascorbic acid or thiourea, sodium pyrosulfite, sodium sulfite etc., it is with being 0.05-4%, disodiumedetate is selected in the complexing of metal ion agent for use, its consumption is 0.01-0.5%, and it is 0.01-0.5% that antiseptic adopts its consumptions such as Nipagin ester, sodium benzoate, and surfactant adopts Tweens, consumption is 0.01-0.5%, is added in the medicinal liquid behind all available dissolved in distilled water of these additives.

Five, dermal osmosis accelerator is selected for use in following material: azone 1-3%, propylene glycol 10-15%, nicotinate 1-2%, salicylic acid 3-4%, and ethyl acetate 5-10%, ethyl lactate 5-10%, dissolved in distilled water is used in also optional wherein two kinds of combinations.

Above-mentioned third and fourth, each compositions of 5 and medicinal liquid (I) and medicinal liquid (II) all mix after preparing, adding distil water is regulated pH value again, reach 100ml, promptly obtain Chinese medicine compound of the present invention and enrich blood and put on the skin, the liniment pH value that is made into is 4.0-7.0, and best PH is 5.0-6.0.

Liniment of the present invention belongs to a kind of exterior-applied formulation, can not be oral or make injection, during use medicinal liquid is coated on the surface skin around child's umbilicus or on the nascent mammiferous basal part of the ear skin of back, for iron Deficiency Anemia and weak, the patient who belongs to deficiency of both QI and blood is evident in efficacy, and is excellent for clinical application effects such as nascent mammal such as piglets, doggie, lambs.

The prevention of liniment of the present invention and treatment anemia mechanism are to embrocate medication by local skin, transdermal penetration absorbs and enters blood circulation, and the whole body pharmacological action takes place, and it and drug administration by injection have some similarity, can be blood absorption, institute's difference is that repeated transmission was delivered to blood, in general after the present invention passed through skin absorbs earlier, though Transdermal absorption is slow, repeatedly medication is not subjected to syringe needle to thrust suffering of flesh but evenly.

The Main Ingredients and Appearance arsenic of liniment of the present invention is a kind of poisonous chemical element, belong to cellular plasm slurry poisonous substance matter, but an amount of scope external that is limiting, significant stimulation bone marrow hematogenesis function is arranged, play strong blood tonification effect, removing toxic substances is sharp, some Saponins in some materials in the Chinese medicinal ingredients such as the milletol in the Caulis Spatholobi, the Radix Angelicae Sinensis oil in the Radix Angelicae Sinensis, Radix Codonopsis, Radix Notoginseng, the Radix Astragali, very easily transdermal penetration is that body absorbs and the strong effect of directly enriching blood under the skin penetrant effect, and is identical with herbal function for oral administration; Fe in Melanteritum and the Chalcanthitum ²⁺, Cn ²⁺Be the synthesis material of hemoglobin, work as Fe ²⁺During shortage, the human or animal very easily suffers from iron deficiency anemia, Cu ²⁺Coordination is arranged, promote Fe ²⁺Absorption, utilization effect, above-mentioned each active ingredient is mended mutually and is coordinated, and uses properly, can enhance metabolism human body immunity improving function, and play the effect of the strengthening body of enriching blood.

The present invention has the following advantages:

One, excavates and enriched chinese tradition medicine culture, filled up the blank of Chinese medicine on Transdermal absorption dosage form aspect enriching blood.

Two, easy to use, need not have an injection and take medicine, only need be coated with and put the same effect that on specific acupuncture point, can play and have an injection and take medicine on the skin with medicinal liquid, use for child or animal, more convenient.

Three, prescription is more flexible, owing to added arsenic compound, Fe ²⁺, Cu ²⁺And the combination of composition such as Chinese medicine, have integrate enrich blood, QI invigorating and strong etc. multi-functional, function is extensive.

Below be embodiments of the invention:

Embodiment one, 1 kilogram of Radix Angelicae Sinensis crude drug is added the method for an amount of distilled water by the water cooking liquid of distillation post processing earlier, collect Radix Angelicae Sinensis oil and water cooking liquid, again 0.8 kilogram of Radix Codonopsis is added an amount of distilled water and decoct, collect decocting liquid, merge above-mentioned two kinds of solution, add ethanol and make that to contain amount of alcohol be about 70%, low temperature is placed more than 8 hours and is filtered, obtain medicinal liquid (II), to take by weighing sodium arsenite or arsenic sulfide 80 grams again and add the dissolving of 10%NaOH solution, medicinal liquid (I), other gets FeSO ₄7H ₂The O600 gram, CuSO ₄5H ₂O100 gram disodiumedetate 10 grams, sodium pyrosulfite 20 grams, Tween 80,800 milliliters, be dissolved in a small amount of distilled water, merge, add azone 400ml with medicinal liquid (I) and medicinal liquid (II), antiseptic is an amount of, add water, regulating PH with HCl or NaOH is 5.8-6.5, and complementing to total liquid measure is 20,000 milliliters, filter, packing gets final product.

Embodiment two, and Caulis Spatholobi, Radix Angelicae Sinensis, Radix Polygoni Multiflori, the Radix Astragali, each 2kg of the Rhizoma Atractylodis Macrocephalae mix and pulverize, flood 3 times repeatedly to there not being the medicine color with 65-70% ethanol, concentrate the Chinese medicine transudate, reclaim ethanol, medicinal residues add an amount of distilled water and decoct, and filter, and filtrate recycling ethanol and leaching concentrated medicament are standby; Accurately take by weighing AS ₂O ₃15 grams, Caustic soda 120 grams add an amount of distilled water and are stirred to dissolving after the mixing, transfer PH near neutral with rare HCl, and standby, other gets an amount of dissolved in distilled water ascorbic acid 100g, EDTA80 gram, Tween 80,100ml, sodium benzoate 40 grams, FeSO ₄7H ₂The O800 gram, CuSO ₄5H ₂The O100 gram mixes above-mentioned various solution, adds azone 300ml, and ethyl acetate 500ml transfers PH to 6.5-7.0 with HCl and NaOH, and supplying distilled water to total amount is 30,000 milliliters, filters, and packing gets final product.

Embodiment three, change Chinese medicine into Radix Rehmanniae Preparata and Radix Notoginseng, and each 2 kilograms, extract medicinal liquid with decocting method, produce 20,000 milliliters of liniments by the method for embodiment one.

Embodiment four, change Chinese medicine into Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae respectively 1.5 kilograms, extract medicinal liquid with separating out alcohol method, and arsenic compound changes sodium methanearsonate 20 grams into, uses dmso solution, and all the other methods are pressed embodiment two, make 30,000 milliliters of liniments.

Use embodiment one,

Product of the present invention uses newborn piglet 1-2 age in days on pig farm, Guilin city, every is coated with and puts skin of back 1-2ml on the skin, only be coated with once, nonuser every of average specific increases weight productive rate more than 30% after 10 days, the no any discomfort in back of applying ointment, have no side effect, the 3rd day skin begins delicate glow under the normal condition, and animal is active, physically well develops, and with matched group relatively, piglet is difficult for taking place diseases such as Huang, Bai Ji.

Use embodiment two,

Product of the present invention in county township, Lipu, Guilin City to 4 years old Lee child * * use, originally Lee * * the thin Huang of face, appetite is few, verifies as iron deficiency anemia through blood drawing, after be coated with this product 3 times, is 2-3ml at every turn, face begins ruddyly after January, appetite is normal.

Claims

1, a kind of Chinese medicine compound hematic tonic liniment contains FeSO ₄And skin penetrant, it is characterized in that the composition of this liniment is:

(1) arsenic compound at arsenic sulfide, arsenic trioxide, potassium arsenite, sodium arsenite, p-aminophenyl arsine and salt thereof, ferric methylarsonate, is chosen any one kind of them in sodium methylarsonate, the swollen sour sodium of dimethyl;

(2) Chinese medicine, optional 1-3 kind or whole in Radix Angelicae Sinensis, Caulis Spatholobi, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, the Radix Paeoniae Alba; Optional 1-3 kind or whole in the middle of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Radix Notoginseng, Radix Glycyrrhizae.

(3) Melanteritum and Chalcanthitum;

(4) antioxidant, metal ion complex, antiseptic, surfactant and dermal osmosis accelerator.

2, Chinese medicine compound hematic tonic liniment according to claim 1, the content that it is characterized in that arsenic compound is the 0.01-2% of total dose, preferred 0.3-0.5%.

3, Chinese medicine compound hematic tonic liniment according to claim 1, the content that it is characterized in that Chinese medicine is the 10-80% of total dose.

4, Chinese medicine compound hematic tonic liniment according to claim 1, the content that it is characterized in that Melanteritum is 20-45%, optimum content is 30-40%; The consumption of Chalcanthitum is 2-20%, and the optimum consumption is 5-10%.

5, Chinese medicine compound hematic tonic liniment according to claim 1 is characterized in that antioxidant is ascorbic acid or thiourea, sodium pyrosulfite, sodium sulfite, and its content is 0.05-4%; Metal ion complex is a disodiumedetate, and its content is 0.01-0.5%; Antiseptic Nipagin ester, sodium benzoate, its content is 0.01-0.5%; Surfactant is a Tweens, and its content is 0.01-0.5%, and dermal osmosis accelerator is azone or propylene glycol, nicotinate, salicylic acid, ethyl acetate or ethyl lactate, and its content is respectively 1-3%, 10-15%, 1-2%, 3-4%, 5-10%, 5-10%.

6, a kind of production method of Chinese medicine compound hematic tonic liniment as claimed in claim 1, it is characterized in that earlier inorganic arsenic chemicals being dissolved in sodium hydroxide or the potassium hydroxide solution, organic arsine is dissolved in polar organic solvent such as dimethyl methyl inkstone, N, in the dinethylformamide, the amount of water distilled water diluting gets main liquid (I); Use separating out alcohol method after getting required Chinese medicine weighing, the decocting method or the way of distillation are extracted its active ingredient, get main liquid (II), then by measuring antioxidant, complexing of metal ion agent, antiseptic, surfactant, dermal osmosis accelerator, use dissolved in distilled water respectively, again and main liquid (I) and (II) merge, regulate PH, adding distil water to 100% promptly obtains compound hematic tonic liniment.