CN1190955A - 结晶[R-(R',R')]-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-[(苯氨基)羰基 - Google Patents
结晶[R-(R',R')]-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-[(苯氨基)羰基 Download PDFInfo
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- CN1190955A CN1190955A CN96195564A CN96195564A CN1190955A CN 1190955 A CN1190955 A CN 1190955A CN 96195564 A CN96195564 A CN 96195564A CN 96195564 A CN96195564 A CN 96195564A CN 1190955 A CN1190955 A CN 1190955A
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- Prior art keywords
- atorvastatin
- type crystallization
- wide
- crystallization atorvastatin
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims abstract description 122
- 159000000007 calcium salts Chemical class 0.000 title claims abstract description 10
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title claims description 122
- 229960005370 atorvastatin Drugs 0.000 title claims description 122
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title claims description 10
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- 238000002425 crystallisation Methods 0.000 claims description 80
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 57
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- 238000000227 grinding Methods 0.000 claims description 11
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- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- OUCSEDFVYPBLLF-KAYWLYCHSA-N 5-(4-fluorophenyl)-1-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-n,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H]2OC(=O)C[C@H](O)C2)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 OUCSEDFVYPBLLF-KAYWLYCHSA-N 0.000 description 1
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- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 1
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- 229910000077 silane Inorganic materials 0.000 description 1
- VVRPOCPLIUDBSA-CNZCJKERSA-M sodium;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate Chemical class [Na+].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 VVRPOCPLIUDBSA-CNZCJKERSA-M 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims (29)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US145295P | 1995-07-17 | 1995-07-17 | |
US60/001,452 | 1995-07-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1190955A true CN1190955A (zh) | 1998-08-19 |
CN1087288C CN1087288C (zh) | 2002-07-10 |
Family
ID=21696090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96195564A Expired - Lifetime CN1087288C (zh) | 1995-07-17 | 1996-07-08 | 结晶[R-(R*,R*)]-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-[(苯氨基)羰基]-1H-吡咯-1-庚酸半钙盐 |
Country Status (38)
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US (1) | US5969156A (zh) |
EP (2) | EP0848705B1 (zh) |
JP (4) | JP3296564B2 (zh) |
KR (2) | KR100431038B1 (zh) |
CN (1) | CN1087288C (zh) |
AR (2) | AR003458A1 (zh) |
AT (3) | ATE208375T1 (zh) |
AU (1) | AU725424B2 (zh) |
BG (1) | BG63630B1 (zh) |
BR (1) | BR9609872A (zh) |
CA (1) | CA2220018C (zh) |
CO (1) | CO4700443A1 (zh) |
CY (1) | CY2358B1 (zh) |
CZ (3) | CZ294695B6 (zh) |
DE (2) | DE69634054T2 (zh) |
DK (2) | DK1148049T3 (zh) |
EA (1) | EA000474B1 (zh) |
EE (1) | EE03606B1 (zh) |
ES (2) | ES2233526T3 (zh) |
GE (1) | GEP20002029B (zh) |
HK (1) | HK1018052A1 (zh) |
HR (1) | HRP960339B1 (zh) |
HU (1) | HU223599B1 (zh) |
IL (7) | IL122118A (zh) |
MX (1) | MX9709099A (zh) |
NO (1) | NO309898B1 (zh) |
NZ (1) | NZ312907A (zh) |
PE (1) | PE1898A1 (zh) |
PL (1) | PL193479B1 (zh) |
PT (2) | PT1148049E (zh) |
RO (1) | RO120070B1 (zh) |
SI (2) | SI1148049T1 (zh) |
SK (1) | SK284202B6 (zh) |
TW (1) | TW486467B (zh) |
UA (1) | UA51661C2 (zh) |
UY (2) | UY24285A1 (zh) |
WO (1) | WO1997003959A1 (zh) |
ZA (1) | ZA966044B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100471836C (zh) * | 2001-07-30 | 2009-03-25 | 雷迪实验室有限公司 | 托伐他汀钙晶型vi和vii |
CN103483238A (zh) * | 2013-08-20 | 2014-01-01 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钙三水合物的制备方法 |
CN103702982A (zh) * | 2011-07-01 | 2014-04-02 | 中化帝斯曼制药有限公司荷兰公司 | 阿托伐他汀半钙的超细晶体 |
CN104945300A (zh) * | 2015-06-17 | 2015-09-30 | 北京嘉林药业股份有限公司 | 一种ⅰ型阿托伐他汀钙的纯化方法 |
Families Citing this family (152)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100471836C (zh) * | 2001-07-30 | 2009-03-25 | 雷迪实验室有限公司 | 托伐他汀钙晶型vi和vii |
CN103702982A (zh) * | 2011-07-01 | 2014-04-02 | 中化帝斯曼制药有限公司荷兰公司 | 阿托伐他汀半钙的超细晶体 |
CN103483238A (zh) * | 2013-08-20 | 2014-01-01 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钙三水合物的制备方法 |
CN103483238B (zh) * | 2013-08-20 | 2014-12-31 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钙三水合物的制备方法 |
CN104945300A (zh) * | 2015-06-17 | 2015-09-30 | 北京嘉林药业股份有限公司 | 一种ⅰ型阿托伐他汀钙的纯化方法 |
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