CN1314392C - Local anesthesia fusion spray cloth for human body local anesthesia and preparing method - Google Patents
Local anesthesia fusion spray cloth for human body local anesthesia and preparing method Download PDFInfo
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- CN1314392C CN1314392C CNB2004100527798A CN200410052779A CN1314392C CN 1314392 C CN1314392 C CN 1314392C CN B2004100527798 A CNB2004100527798 A CN B2004100527798A CN 200410052779 A CN200410052779 A CN 200410052779A CN 1314392 C CN1314392 C CN 1314392C
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- fusion
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- local anesthesia
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- spray cloth
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Abstract
The present invention belongs to the technical field of medical materials. The present invention provides a local anesthesia fusion and spraying product for human body local anesthesia. The product comprises local anesthesia medicine and a fusion and spraying carrier of a non-poisonous polymer. The product of the present invention has the characteristics that the local anesthesia medicine is continuously and uniformly released; the fusion and the spraying are thin, and the hand feelings are soft. The present invention is favorable to reduce the pain feelings of wounds, and the present invention is suitable for clinical usage. The present invention adopts fusion and spraying fiber nets of physical adhesion; the time of high-temperature operation is short, and the decomposition is hard to occur. The method of the present invention is favorable for the scale commercial production.
Description
Technical field:
The invention belongs to medical material tech field.Be specifically related to a kind of local anesthesia (local anaesthesia) fusion spray cloth product that is used for human body local anesthesia and preparation method thereof.
Background technology:
Clinically, operate on, burn because of operation or the pain of scald etc., and avoid the untoward reaction that causes because of pain for alleviating human body, adopt usually human body among a small circle in the medical procedure of enforcement local anesthesia (local anaesthesia).At present the local anaesthesia method that adopts has: for example inject or quiet notes local anesthetic, but the method is often because of the disposable high toxic and side effects of concentration that enters human body is bigger, and lacks with medical treatment cost height, curative effect; Another kind method is that local anesthesia fiber (local anaesthesia fiber) is made the dressing wrapping or sticked on human body wound mouth, play local anesthetic action, but wherein the preparation of local anaesthesia fiber is to adopt the chemical graft method, this method production cost height, technological process are long, and by the local anaesthesia dressing of local anaesthesia fiber production when being used for human body local anesthesia, often exist medicament to discharge uneven defective.The inventor has designed a kind of employing physical blending method through research, and the local anaesthesia medicament is become the technology of fiber with nontoxic macromolecule melt co-blended spinning, sees Chinese patent application numbers 200410024984.3.But this medical dressing also is a process makes medical cloth with fiber, and then makes medical dressing, and therefore above-mentioned process route is still long.
Summary of the invention:
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and the research design flow process is shorter, the technology of the preparation local anaesthesia fusion spray cloth that operation is easy.
The invention provides a kind of local anaesthesia fusion spray cloth product that is used for human body local anesthesia, this local anaesthesia fusion spray cloth product comprises active component local anesthetic and nontoxic level polymer fusion spray cloth carrier composition, and wherein the addition of local anesthetic in local anaesthesia fusion spray cloth product is in weight % 8.0～25.0%.
The local anesthetic that the present invention selects for use is tetracaine, bupivacaine, procaine or lignocaine; The polymer support that fusion spray cloth is selected for use is polyethylene or polypropylene.
Another object of the present invention provides a kind of manufacture method that is used for the local anaesthesia fusion spray cloth of human body local anesthesia.
Technology path of the present invention is:
Polymer support (polyethylene or polyacrylic section) → screw rod fusion → dosing pump → melt and spray template → hot-air stretching → fleece to accept tube → local anesthesia fusion spray cloth injection local anaesthesia medicament → shaping reel → packing.
Method of the present invention comprises the following steps:
Choosing of polymer support in conjunction with the characteristics that melt and spray spinning, selected the section of the nontoxic polymer support of high fusion index for use, and polypropylene or poly melt index are: 30～500;
Screw rod fusion: polyethylene or the section of polypropylene high fusion index are entered extruder type spinning machine fusion metering extruding, when extruding, pass through preheating zone, a district, two districts, three districts and bend pipe flange district respectively;
Injection is drawn into cloth: after the macromolecule melt after the uniform temperature fusion forms certain pressure, by template injection thread, stick to rustless steel after the air high-speed stretch by heating and accept tube, when melting and spraying thread near softening point, evenly be sprayed on local anaesthetics in the fusion spray cloth, thereby among the fusion spray cloth that the powdery local anaesthetics is sticked to equably batch, form and melt and spray local anaesthesia cloth by the fleece lay-up.
The screw spinning that melts and sprays the molten polymer section in the inventive method is respectively distinguished temperature and is respectively: 90～95 ℃ of preheating zones; One district: 100～150 ℃; Two districts: 160～205 ℃; Three districts: 170～280 ℃; Bend pipe flange district: 160～260 ℃.
The melt blown die plate temperature is 220～350 ℃ in the inventive method; Hot blast temperature is 280～320 ℃; Blast is 1.2～8.0kg/cm
2It is 110～150 ℃ that meltblown fiber web is accepted the tube temperature; Fusion spray cloth coiling speed: 20～100m/min, local anaesthetics expulsion pressure: 0.1～1.2kg/cm
2
Principle of the present invention is that local anaesthetics is distributed in the polyethylene of high fusion index or the fusion spray cloth that the polypropylene injection forms equably, makes the biological activity fusion spray cloth that human body is had anesthetic action.Wherein active component is a local anaesthetics, by local anaesthetics being sprayed being bonded in the screen cloth in the fusion spray cloth thread, when this fusion spray cloth dressing that contains local anaesthetics touches the skin trauma mouth of human body mucosa or breakage, local anaesthetics wherein is discharged in the microcirculation in human body by people's body fluid lentamente, thereby alleviate human body pain, reach the effect of human body local anesthesia.
It is as follows that the every after tested gram of local anaesthesia fusion spray cloth product of the present invention melts and sprays in the local anaesthesia cloth seven days burst size:
Time local anaesthetics burst size (mg)
First day 5.8
Second day 4.2
The 3rd day 3.1
The 4th day 1.12
The 5th day 0.90
The 6th day 0.51
The 7th day 0.31
This melts and sprays local anaesthesia cloth sample polymer support: polypropylene, the local anaesthetics of interpolation: tetracaine, addition: 16%.
Product of the present invention has following characteristics:
1. melt and spray local anaesthesia cloth and have the advantages that to continue evenly to discharge local anaesthetics, therefore can avoid adopting the excessive toxic and side effects that causes of injection local anaesthetics concentration, very convenient simple when the patient uses.
2. the present invention adopts the physical adherence meltblown fiber web, and the high-temperature operation time is short, and the local anaesthesia medicament is difficult for decomposing.
3. the fusion spray cloth fiber finer is soft, helps reducing the pain of wound.
The specific embodiment:
Embodiment 1
Raw material: polypropylene chip (nontoxic high fusion index)
Melt index: 100
Local anaesthetics composition: tetracaine (addition 16%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
92 165 198 205 210
Melt blown die plate temperature: 289 ℃
Hot blast temperature: 310 ℃
Hot-blast pressure: 3.5kg/cm
2
Melt and spray and accept net tube temperature: 130 ℃
Local anaesthetics expulsion pressure: 0.2kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 8 days.
Embodiment 2
Raw material: polypropylene chip (nontoxic fibre-grade)
Melt index: 48
Local anaesthetics composition: bupivacaine (addition 15%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
90 135 170 180 185
Melt blown die plate temperature: 272 ℃
Hot blast temperature: 285 ℃
Hot-blast pressure: 2.8kg/cm
2
Melt and spray and accept net tube temperature: 115 ℃
Local anaesthetics expulsion pressure: 0.18kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 9 days.
Embodiment 3
Raw material: polypropylene chip (nontoxic fibre-grade)
Melt index: 150
Local anaesthetics composition: procaine (addition 20%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
90 150 189 195 205
Melt blown die plate temperature: 278 ℃
Hot blast temperature: 300 ℃
Hot-blast pressure: 3.2kg/cm
2
Melt and spray and accept net tube temperature: 120 ℃
Local anaesthetics expulsion pressure: 0.32kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 13 days.
Embodiment 4
Raw material: polypropylene chip (nontoxic high fusion index)
Melt index: 55
Local anaesthetics composition: lignocaine (addition 25%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
90 125 155 178 170
Melt blown die plate temperature: 268 ℃
Hot blast temperature: 278 ℃
Hot-blast pressure: 2.6kg/cm
2
Melt and spray and accept net tube temperature: 105 ℃
Local anaesthetics expulsion pressure: 0.35kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 16 days.
Claims (3)
1, a kind of local anesthesia fusion spray cloth product that is used for human body local anesthesia, it is characterized in that this product is by forming as the local anesthetic of active ingredient and nontoxic level polymer fusion spray cloth carrier, wherein the addition of local anesthetic in local anesthesia fusion spray cloth product is that this product makes by following method in weight % 8.0～25.0%:
(1) choosing of polymer support: selecting the spinning melt index for use is the section of the nontoxic level polymer support of 30-500;
(2) screw rod fusion: the polymer chips that step (1) is selected for use enters extruder type spinning machine fusion metering extruding, passes through 90～95 ℃ of preheating zones when extruding respectively; One district: 100～150 ℃; Two districts: 160～205 ℃; Three districts: 170～280 ℃; Bend pipe flange district: 160～260 ℃;
(3) injection is drawn into cloth: the macromolecule melt after step (2) fusion is under following condition:
The melt blown die plate temperature is 220～350 ℃; Hot blast temperature is 280～320 ℃; Blast is 1.2～8.0kg/cm
2It is 110～150 ℃ that meltblown fiber web is accepted the tube temperature; Fusion spray cloth coiling speed: 20～100m/min, local anaesthetics expulsion pressure: 0.1～1.2kg/cm
2By template injection thread, stick to rustless steel after the air high-speed stretch by heating and accept tube, when melting and spraying thread near softening point, evenly be sprayed on local anesthetic in the fusion spray cloth, thereby among the fusion spray cloth that the powdery local anesthetic is sticked to equably batch, form and melt and spray local anesthesia cloth by the fleece lay-up.
2, a kind of preparation method that is used for the local anesthesia fusion spray cloth product of human body local anesthesia is characterized in that this method comprises the following steps:
(1) choosing of polymer support: selecting the spinning melt index for use is the section of the nontoxic level polymer support of 30-500;
(2) screw rod fusion: the polymer chips that step (1) is selected for use enters extruder type spinning machine fusion metering extruding, passes through 90～95 ℃ of preheating zones when extruding respectively; One district: 100～150 ℃; Two districts: 160～205 ℃; Three districts: 170～280 ℃; Bend pipe flange district: 160～260 ℃;
(3) injection is drawn into cloth: the macromolecule melt after step (2) fusion is under following condition:
The melt blown die plate temperature is 220～350 ℃; Hot blast temperature is 280～320 ℃; Blast is 1.2～8.0kg/cm
2It is 110～150 ℃ that meltblown fiber web is accepted the tube temperature; Fusion spray cloth coiling speed: 20～100m/min, local anaesthetics expulsion pressure: 0.1～1.2kg/cm
2By template injection thread, stick to rustless steel after the air high-speed stretch by heating and accept tube, when melting and spraying thread near softening point, evenly be sprayed on local anesthetic in the fusion spray cloth, thereby among the fusion spray cloth that the powdery local anesthetic is sticked to equably batch, form and melt and spray local anesthesia cloth by the fleece lay-up; Wherein the addition of local anesthetic in local anesthesia fusion spray cloth product is in weight % 8.0～25.0%.
3, a kind of local anesthesia fusion spray cloth product that is used for human body local anesthesia according to claim 1 is characterized in that wherein said local anesthetic is selected from tetracaine, bupivacaine, procaine or lignocaine; Polymer is selected from polyethylene or polypropylene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100527798A CN1314392C (en) | 2004-07-13 | 2004-07-13 | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100527798A CN1314392C (en) | 2004-07-13 | 2004-07-13 | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method |
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| Publication Number | Publication Date |
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| CN1586461A CN1586461A (en) | 2005-03-02 |
| CN1314392C true CN1314392C (en) | 2007-05-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100527798A Expired - Fee Related CN1314392C (en) | 2004-07-13 | 2004-07-13 | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588917A (en) * | 2020-05-15 | 2020-08-28 | 广东顺事德智能科技有限公司 | Melt-blown cloth for local anesthesia of human body and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US398185A (en) * | 1889-02-19 | Mail-bag | ||
| US5503908A (en) * | 1992-12-22 | 1996-04-02 | Kimberly-Clark Corporation | Self-adhesive nonwoven elastic compressible composite material |
| CN1362601A (en) * | 2000-12-28 | 2002-08-07 | 诺德森公司 | Air-flow control system for producing non-woven fabric and multi-layer boned fabric |
| CN1386147A (en) * | 2000-08-04 | 2002-12-18 | 纳幕尔杜邦公司 | Meltblown nonwoven fabric |
| CN1420730A (en) * | 2000-04-06 | 2003-05-28 | 金伯利-克拉克环球有限公司 | Disposable finger sleeve for appendages |
-
2004
- 2004-07-13 CN CNB2004100527798A patent/CN1314392C/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US398185A (en) * | 1889-02-19 | Mail-bag | ||
| US5503908A (en) * | 1992-12-22 | 1996-04-02 | Kimberly-Clark Corporation | Self-adhesive nonwoven elastic compressible composite material |
| CN1420730A (en) * | 2000-04-06 | 2003-05-28 | 金伯利-克拉克环球有限公司 | Disposable finger sleeve for appendages |
| CN1386147A (en) * | 2000-08-04 | 2002-12-18 | 纳幕尔杜邦公司 | Meltblown nonwoven fabric |
| CN1362601A (en) * | 2000-12-28 | 2002-08-07 | 诺德森公司 | Air-flow control system for producing non-woven fabric and multi-layer boned fabric |
Non-Patent Citations (6)
| Title |
|---|
| 国外低纤度短纤丙纶的生产设备及生产技术 端木媚莉，西北纺织工业学院学报，第11卷第3期 1997 * |
| 提高熔喷产品档次和质量的探讨 谢祖谕，非织造布，第3期 1995 * |
| 氮纶熔融纺织生产工艺的探讨 周建平，江苏纺织，第10期 2002 * |
| 氮纶熔融纺织生产工艺的探讨 周建平，江苏纺织，第10期 2002;国外低纤度短纤丙纶的生产设备及生产技术 端木媚莉，西北纺织工业学院学报，第11卷第3期 1997;耐热纤维的开发及应用 杜选，吴明丽，杨哲，刘金凤，北京纺织，第3期 2002;熔喷法聚丙烯非织造布滤材 石波、安树林，天津纺织科技，第41卷第1期 2003;提高熔喷产品档次和质量的探讨 谢祖谕，非织造布，第3期 1995 * |
| 熔喷法聚丙烯非织造布滤材 石波、安树林，天津纺织科技，第41卷第1期 2003 * |
| 耐热纤维的开发及应用 杜选，吴明丽，杨哲，刘金凤，北京纺织，第3期 2002 * |
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