CN1323527A - Inorganic copper and silver antiseptic - Google Patents
Inorganic copper and silver antiseptic Download PDFInfo
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- CN1323527A CN1323527A CN 00112290 CN00112290A CN1323527A CN 1323527 A CN1323527 A CN 1323527A CN 00112290 CN00112290 CN 00112290 CN 00112290 A CN00112290 A CN 00112290A CN 1323527 A CN1323527 A CN 1323527A
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- silver
- copper
- durability
- antimicrobial
- oxalate
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention velates to an inorganic antimicrobial adopting hard soluble compound that contains elements of silver or copper such as silver tungstate, silver oxalate, silver thiocyanate, silver bromide, silver iodide, cupric wolframate, copper oxalate. This antimicrobial has high safety, durability, not easy to produce drug resistance etc. In particular, this invention does not adopt carrier to obtain slow release feature and durability, so it is easy to produce, and can be used directly or mixed with other material. This antimicrobial can be applied to cosmetics, plastic, building materials, fiber, glass, ceramics, environmental water treatment agent etc.
Description
The present invention relates to inorganic antiseptic, especially the inorganic antiseptic of silver, copper compounds.
In recent years, because people's living standard improves, health level is had higher requirement, and inorganic antiseptic has the organic antibacterial agent of being better than part, inorganic antiseptic has obtained extensive studies and application, inorganic antiseptic is containing the antibacterial agent of antibiotic property metal ion in the compound, and as metal ions such as silver, copper, that wherein antibiotic property is the strongest is silver ion (Ag
+), next copper ion (Cu
++), be that antibiotic ion is micro-but high security is arranged as its advantage of inorganic antiseptic efficiently.Quick released ion concentration height, poor stability; Durability requires the antibiotic property metal ion slowly to discharge or slow stripping metal ion, for the purpose that reaches slow release be with antibiotic property ion appendix on carrier.So, present carrier has main carrier such as phosphate carrier, silicate carrier and activated carbon, slow release is to be interacted by carrier and antibiotic property metal ion to decide, active force is too strong, and not stripping of metal ion does not have antibiotic property, active force too a little less than, the direct stripping of metal ion, antibiotic property is strong, but has durability and safety issue.At present, can't freely control, select different inorganic compound carriers to obtain different results the load force of antibiotic property metal ion, so, utilize carrier to make its manufacturing process complexity of inorganic antiseptic, technological requirement height with safety, durability.
Purpose of the present invention provides the silver, the inorganic copper antibacterial agent that have slow release, durability without carrier.
The method that realizes the object of the invention is to be inorganic antiseptic with insoluble compound silver-colored, copper, and the compound with this performance is wolframic acid silver, silver oxalate, silver thiocyanate, silver bromide, silver iodide, copper tungstate, cupric oxalate.
Because its solvability of insoluble compound of silver, copper is very little, the concentration of metal ions of its saturated solution is sufficient to play bactericidal action, and, in very long period, antibacterial effect is arranged, so have slow release and persistence, in addition, with silver, the copper insoluble compound is as antibacterial agent, it does not need owing to the sustained release performance that produces with carrier interactions, so, easy to make, easily processing can directly be used or mixes with other object or make the masterbatch use.
The present invention is further illustrated below in conjunction with embodiment;
Embodiment:
The preparation of a bacteria suspension: bacterial classification inoculation in the liquid shaking bottle medium of 50ml, was cultivated 18～24 hours, with bacterium liquid 1ml (about 10
8Cell/ml) join in the phosphate buffer (PBS) of 100ml, make bacteria suspension.B makes saturated solution with various antibacterial agents, and the concentration of metal ions in its saturated solution is:
Wolframic acid silver～500mg/l
Silver oxalate～40mg/l
Silver thiocyanate～0.2mg/l
Silver bromide～0.1mg/l
Silver iodide～0.03mg/l
Copper tungstate～100mg/l
Cupric oxalate～30mg/l
C gets the saturated solution 4.5ml of above-mentioned silver, copper compound respectively, is added to respectively among the 4mlPBS, adds the 0.5ml bacteria suspension after the sterilization respectively, vibrates 1～2 minute, is incubated 90 minutes down at 37 ℃, sample is taken out dilution 10～10
5Doubly count with rubbing method the back, and the sterilizing rate that calculates above-mentioned each silver, copper insoluble compound reaches more than 99.9%.
Advantage of the present invention 1 is safe, particularly in vivo difficult accumulation and having seldom in water of silver ion Solubility; 2 durability are long, and the compound that silver, copper can be made indissoluble water has slow release and durability, In for a long time, has antibacterial effect; 3. broad spectrum antibacterial: silver ion to bacterium have very strong antibiotic, kill The bacterium ability ranks the first, and copper ion has very strong antibiotic, sterilizing ability to come second to bacterium; 4 are not Easily develop immunity to drugs; 5. has higher durability than general organic antibacterial agent; 6. workability can be direct Use or mixes with other object or make the masterbatch use, so can be applied to cosmetics, plastic products, build Material (coating), fibre, glass, pottery, paper, water treatment agent etc.
Claims (2)
1. a silver, inorganic copper antibacterial agent is characterized in that: the insoluble compound that adopts silver, copper.
2. silver according to claim 1, inorganic copper antibacterial agent is characterized in that: the insoluble compound of silver, copper is wolframic acid silver, silver oxalate, silver thiocyanate, silver bromide, silver iodide, copper tungstate, cupric oxalate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112290 CN1323527A (en) | 2000-05-16 | 2000-05-16 | Inorganic copper and silver antiseptic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112290 CN1323527A (en) | 2000-05-16 | 2000-05-16 | Inorganic copper and silver antiseptic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1323527A true CN1323527A (en) | 2001-11-28 |
Family
ID=4582160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00112290 Pending CN1323527A (en) | 2000-05-16 | 2000-05-16 | Inorganic copper and silver antiseptic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1323527A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003018498A1 (en) * | 2001-08-22 | 2003-03-06 | Schott Glas | Antimicrobial, anti-inflammatory, wound-healing and disinfecting glass and use thereof |
| EP1449816A1 (en) * | 2003-02-20 | 2004-08-25 | Gemtron Corporation | Antimicrobial glass and glass-like products and method of preparing same |
| US7192602B2 (en) | 2001-08-22 | 2007-03-20 | Schott Ag | Water-insoluble, antimicrobial silicate glass and use thereof |
| CN1307120C (en) * | 2002-11-29 | 2007-03-28 | 株式会社品燃洁而美客 | Antibacterial agent for concrete, concrete compositions and concrete products |
| US7709027B2 (en) | 2001-08-22 | 2010-05-04 | Schott Ag | Antimicrobial, anti-inflammatory, wound-healing glass powder and use thereof |
| CN1889829B (en) * | 2003-12-04 | 2011-05-04 | 巴斯福股份公司 | Antimicrobial compositions comprising polymeric stabilizers |
| US8080490B2 (en) | 2003-02-25 | 2011-12-20 | Schott Ag | Antimicrobial phosphate glass |
| CN104445414A (en) * | 2014-11-02 | 2015-03-25 | 河北联合大学 | Two novel preparation methods for antibacterial cupric tungstate nanopowder |
| CN104430529A (en) * | 2014-11-02 | 2015-03-25 | 河北联合大学 | Method for synthesizing tungstate antibacterial composition through microwave heating/microwave-molten salt method |
| CN107953433A (en) * | 2017-12-21 | 2018-04-24 | 安徽明豪实木家俱有限公司 | A kind of method of Calophyllum preservative treatment |
| CN109169706A (en) * | 2018-07-19 | 2019-01-11 | 大美泰康（天津）生态科技有限公司 | Complex antimicrobials and antibacterial bacteriostatic type multifunctional inorganic ecologic coating obtained |
-
2000
- 2000-05-16 CN CN 00112290 patent/CN1323527A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7166549B2 (en) | 2001-08-22 | 2007-01-23 | Schott Ag | Antimicrobial, anti-inflammatory, wound-healing and disinfecting glass and use thereof |
| US7192602B2 (en) | 2001-08-22 | 2007-03-20 | Schott Ag | Water-insoluble, antimicrobial silicate glass and use thereof |
| US7709027B2 (en) | 2001-08-22 | 2010-05-04 | Schott Ag | Antimicrobial, anti-inflammatory, wound-healing glass powder and use thereof |
| WO2003018498A1 (en) * | 2001-08-22 | 2003-03-06 | Schott Glas | Antimicrobial, anti-inflammatory, wound-healing and disinfecting glass and use thereof |
| CN1307120C (en) * | 2002-11-29 | 2007-03-28 | 株式会社品燃洁而美客 | Antibacterial agent for concrete, concrete compositions and concrete products |
| EP1449816A1 (en) * | 2003-02-20 | 2004-08-25 | Gemtron Corporation | Antimicrobial glass and glass-like products and method of preparing same |
| US8080490B2 (en) | 2003-02-25 | 2011-12-20 | Schott Ag | Antimicrobial phosphate glass |
| CN1889829B (en) * | 2003-12-04 | 2011-05-04 | 巴斯福股份公司 | Antimicrobial compositions comprising polymeric stabilizers |
| CN104445414A (en) * | 2014-11-02 | 2015-03-25 | 河北联合大学 | Two novel preparation methods for antibacterial cupric tungstate nanopowder |
| CN104430529A (en) * | 2014-11-02 | 2015-03-25 | 河北联合大学 | Method for synthesizing tungstate antibacterial composition through microwave heating/microwave-molten salt method |
| CN104430529B (en) * | 2014-11-02 | 2018-07-17 | 华北理工大学 | The method of microwave heating/microwave-molten-salt growth method synthesis tungstates bactericidal composition |
| CN107953433A (en) * | 2017-12-21 | 2018-04-24 | 安徽明豪实木家俱有限公司 | A kind of method of Calophyllum preservative treatment |
| CN109169706A (en) * | 2018-07-19 | 2019-01-11 | 大美泰康（天津）生态科技有限公司 | Complex antimicrobials and antibacterial bacteriostatic type multifunctional inorganic ecologic coating obtained |
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