CN1356883A - 具有药剂导入构造的真空辅助闭合系统 - Google Patents

具有药剂导入构造的真空辅助闭合系统 Download PDF

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CN1356883A
CN1356883A CN00805800A CN00805800A CN1356883A CN 1356883 A CN1356883 A CN 1356883A CN 00805800 A CN00805800 A CN 00805800A CN 00805800 A CN00805800 A CN 00805800A CN 1356883 A CN1356883 A CN 1356883A
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R·W·约翰森
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Abstract

一种方法和装置,用于向处于真空辅助闭合(VAC)治疗下的伤口引入伤口治疗药剂,通常包括泡沫垫(11),用于基本上插入到伤口部位(12)中,和伤口消毒盖布(13),用于将泡沫垫11封闭在伤口部位12处。泡沫垫处于与真空源流体连接中用于促进流体的排放。另外,通过现有技术中已知的移植或其他技术,利用对于现有技术来讲同样已知的碱性成纤维细胞(bFGF)生长因子、抗菌剂或其它因子对泡沫垫进行预先处理,用于促进伤口治疗的加快。

Description

具有药剂导入构造的真空辅助闭合系统
相关的申请
本申请要求系列号为No.60/127,595的美国临时专利申请的优先权，其名称为“具有药剂导入构造的真空辅助闭合系统”申请日为1999年4月2日。通过该引用，在这里引入包括其附图的美国临时专利申请No.60/127,595的全部内容。
技术领域
本发明涉及伤口的治疗。更具体地，本发明涉及伤口的真空辅助闭合，其中为了促进伤口的治疗，通过移植VAC垫向伤口位置导入生长因子或其它药剂。
背景技术
伤口闭合包括伤口附近的上皮和皮下组织的向内的移行。该移行通常是通过发炎过程实现的，从而血液流量增大并且激活各种功能性细胞。在发炎过程中，通过毛细管一级的闭塞停止穿过受伤或破裂血管的血液流动，在此之后开始清理和重建过程。不好的是，当伤口很大或者已经感染时该过程受到阻碍。在这种伤口中，郁积部分(即，其中具有阻碍血液流动到组织中的膨胀组织部分)接近伤口表面形成。
没有足够的血液流动，围绕伤口的上皮和皮下组织不仅接受减少了的氧气和营养物质，而且还几乎不能成功地对付细菌的感染，并且因此很少能够自然地闭合伤口。直到最近，仅仅通过使用缝合线或纤维处理这种困难的伤口。尽管仍然广泛地实践并且通常是有效的，这种机械闭合技术导致的主要缺陷在于，它们在伤口附近的皮肤组织上产生张力。具体地，为了实现闭合采用缝合线或纤维所需要的拉伸力在缝合线或纤维插入的位置引起非常高的局部应力。这些应力常引起插入位置的组织破裂，这可能甚至引起伤口的裂开和附带的组织损伤。
另外，有些伤口由于感染而变硬和发炎到一定程度，以至于不可能通过纤维或缝合线来闭合。不能通过纤维或缝合线治疗的伤口通常需要更长时间的住院治疗，伴有额外的高成本，和较大的外科处理，例如周围组织的皮肤移植。不能通过纤维或缝合线简单地治疗的伤口例子包括大、深、有开口的伤口，褥疮，慢性骨髓炎导致的溃疡，和基本上发展到整个烧伤深度的局部重度烧伤。
作为机械闭合装置的这些和其它缺点的结果，已经提出了通过作用连续的负压力来吸收伤口的方法和装置。当在伤口的足够大的面积上作用时，已经发现这种负压力加速朝向伤口的上皮和皮下组织的移行。在实践中，向伤口使用负压力，通常称为真空辅助闭合(VAC)疗法，通常包括伤口的机械类型的收缩和同时清除多余的液体。在这种方式中，VAC疗法增大人体的自然发炎过程同时减轻任何已知的固有的副作用，例如由于缺少正常的静脉血回流所需要的血管组织而导致血流量增大引起浮肿的产生。
虽然VAC疗法已经在促进伤口闭合中取得很大的成功，治疗了很多以前认为很难处理的伤口，但仍然存在一些困难。由于发炎过程对于每个个体病人都非常不同，甚至VAC疗法的加入不会导致足够快的反应，特别是在闭合、初步清除和重建过程中为了适当地处理一些伤口。因此本发明的一个基本目的在于提供一种方法和装置，通过引入加快伤口治疗的生长因子和/或其它药剂从而改进已知的VAC疗法特征。
发明内容
根据上面所述目的，本发明是一种方法和装置，用于向接受真空辅助闭合(VAC)治疗的伤口引入伤口治疗药剂，通常包括泡沫垫，基本上插入到伤口部位中；和伤口消毒盖布，用于将泡沫垫封闭在伤口部位中。根据本发明，泡沫垫处于与真空源流体连接中用于促进流体的排放。另外，通过现有技术中已知的移植或其他技术，利用对于现有技术来讲同样已知的碱性成纤维细胞(bFGF)生长因子、抗菌剂或其它因子对泡沫垫进行预先处理，用于促进伤口治疗的加快。
根据本发明的优选方法，通过改善VAC系统所必需的泡沫垫，预先向已知的VAC疗法中添加生长因子或其它伤口治疗药剂。已经知道这些生长因子例如碱性成纤维细胞生长因子(bFGF)基于自身有力的血管生成和肉芽组织形成活性来加速伤口的治疗。如已经证明的即使对于很难治疗的伤口，例如受到感染的伤口、烧伤伤口和糖尿病伤口，作为结果而发生的活性引起伤口的快速的上皮重新覆盖和收缩。通过对泡沫垫的改进和利用bFGF对其进行的预处理，因此VAC疗法与生长因子导入的结合被认为是对伤口治疗领域的重要贡献。
最后，本发明的许多其它特征、目的和优点对于相关领域的普通技术人员都是很清楚的，特别是根据前面的讨论、以下的附图和示例性的详细说明和所附权利要求。
附图的简要说明
尽管本发明的范围远远宽于任何一个具体的实施例，下面是结合示例性附图对优选实施例的详细说明，其中相同的附图标记表示相同的部件，并且其中：
具体地以局部剖视图形式，该图表示作用到哺乳动物伤口部位的本发明优选实施例。
实施发明的最佳实施方式
尽管本领域的技术人员已经承认许多变形的实施例，特别是根据这里给出的结合附图的解释，该详细说明是本发明优选实施方案的一个示例，即一种真空辅助闭合系统具有导入药剂的构造，它的范围仅仅受到所附权利要求书的限定。
现在参照图，表示本发明10通常包括泡沫垫11，用于基本上插入到伤口部位12中，和伤口消毒盖布13，用于将泡沫垫11封闭在伤口部位12处。根据本发明，泡沫垫11处于与真空源流体连接中用于促进流体的排放。另外，通过现有技术中已知的移植或其他技术，利用对于现有技术来讲同样已知的碱性成纤维细胞(bFGF)生长因子、抗菌剂或其它因子对泡沫垫进行预先处理，用于促进伤口治疗的加快。
根据本发明的优选实施方案，如现有技术中已知的那样使用泡沫垫11、伤口消毒盖布13和真空源，在1995年8月22日递交的系列号为No.08/517901的美国专利申请中有相应的描述。这里将包括权利要求和附图的系列号为No.08/517901的美国专利申请(‘901申请)的全部内容完全作为参考。另外，通过美国德克萨斯州圣安东尼奥的Kinetic Concepts，Inc.公司和/或它的子公司可以很容易地购买到这种VAC系统。
如在‘901申请中详细描述的，泡沫垫11优选地包括网状的、带有开口网格的聚氨酯或聚醚泡沫，用于在吸收的过程中为伤口流体提供良好的透过性，但在本发明中由于需要导入所需的药剂，可以包括传统的海绵纤维绷带。如已经在‘901申请中描述的，通过塑料或类似材料的软管14，泡沫垫11优选处于与真空源流体连接中，通过插入其中的疏水薄膜过滤器，真空源优选包括确实处于与真空泵流体连接的真空中的滤毒器。最后，‘901申请还描述了伤口消毒盖布13，优选包括弹性材料，至少其周围覆盖有对压力敏感的丙烯酸粘合剂，用于在伤口部位12上起密封作用。
根据本发明的优选方法，在‘901申请中描述的这些部件通常如现有技术中已知的那样使用，除了由于需要引入生长因子而对本发明的泡沫垫11做了改进以外。已知例如碱性成纤维细胞生长因子(bFGF)等生长因子基于自身有力的血管生成和肉芽组织形成活性来加速伤口的治疗。如已经证明的即使对于很难治疗的伤口，例如受到感染的伤口、烧伤伤口和糖尿病伤口，作为结果而发生的活性引起伤口的快速的上皮重新覆盖和收缩。通过对泡沫垫的改进和利用bFGF对其进行的预处理，因此VAC疗法与生长因子导入的结合被认为是对伤口治疗领域的重要贡献。同样地，本方法提出向伤口部位12引入抗菌剂的最好时机，无论单独地还是与bFGF或其它药剂相结合。
虽然前面的描述是本发明优选实施方案的示例，相关技术领域的技术人员将承认已经可能的许多改变、变形、改进、替代等等，特别是根据这里的说明书、所附附图和权利要求书。例如，本领域的普通技术人员会了解，虽然本发明的优选实施方案包括将所需药剂移植到VAC系统的泡沫垫11中，利用该示例性说明的启示，本领域普通技术人员将很容易地得到用于导入所需药剂的任何基本上等效的方式。例如，在泡沫垫11没有利用药剂预先处理或者已经利用药剂预先处理但经过一段时间药剂基本上已经融合到伤口部位12中的情况下，所需药剂可以利用针剂或注射器等穿过伤口消毒盖布13注射到泡沫垫11中。在任何一种情况中，由于本发明的范围远远宽于任何一个具体的实施例，前面详细的说明将不能看作是对本发明的限制，仅仅通过所附权利要求进行限定。
工业应用性
本发明适用于伤口治疗领域。

Claims (10)

1.一种组合治疗方法，用于促进哺乳动物的伤口治疗，所述组合治疗方法包括：
多孔垫，流体能够渗透并且适合于放置在由伤口表面的部分限定的可封闭的空间内；
导管，具有与所述多孔垫流体连接的第一端，和与真空源流体连接的第二端，所述真空源用来通过所述导管向所述多孔垫施加负压力；和
利用伤口治疗因子对所述多孔垫进行预处理。
2.如权利要求1所述的组合治疗方法，其中所述伤口治疗因子包括碱性成纤维细胞生长因子。
3.如权利要求2所述的组合治疗方法，其中所述碱性成纤维细胞生长因子移植到所述多孔垫中。
4.如权利要求1所述的组合治疗方法，其中所述伤口治疗因子包括抗菌剂。
5.如权利要求4所述的组合治疗方法，其中所述抗菌剂包括抗生素。
6.如前述任何一个权利要求所述的组合治疗方法，其中所述多孔垫由多种伤口治疗因子预先进行处理。
7.如前述任何一个权利要求所述的组合治疗方法，其中所述组合治疗方法还包括伤口消毒盖布，用于将所述多孔垫封闭在所述可封闭的空间内。
8.如权利要求7所述的组合治疗方法，其中通过注射穿过所述伤口消毒盖布向所述多孔垫引入一定剂量的伤口治疗因子。
9.如权利要求8所述的组合治疗方法，其中所述一定剂量的伤口治疗因子添加到用所述伤口治疗因子预先处理的所述多孔垫上。
10.如权利要求9所述的组合治疗方法，其中所述一定剂量的伤口治疗因子包括与预先处理在所述多孔垫上的所述伤口治疗因子相同类型的因子。
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CN1732028B (zh) * 2002-10-28 2010-04-21 史密夫及内修公开有限公司 抽吸、冲洗和净化创伤用装置
CN101257876B (zh) * 2005-09-07 2012-07-04 泰科保健集团有限合伙公司 整装的伤口敷料装置
CN101454043B (zh) * 2006-06-02 2012-07-11 凯希特许有限公司 伤口抽吸钉装置
CN102046219A (zh) * 2008-05-30 2011-05-04 凯希特许有限公司 用于在关节上使用的减压压缩系统和装置
CN102046219B (zh) * 2008-05-30 2013-08-21 凯希特许有限公司 用于在关节上使用的减压压缩系统和装置
CN102724945A (zh) * 2010-01-29 2012-10-10 凯希特许有限公司 用于定位流体供应系统的系统和方法
CN102724945B (zh) * 2010-01-29 2015-03-11 凯希特许有限公司 用于定位流体供应系统的系统和方法
CN110612076A (zh) * 2016-12-22 2019-12-24 应用纸巾技术有限公司 用于伤口处理的装置和方法
CN106963555A (zh) * 2017-05-10 2017-07-21 马世香 一种创伤护理装置

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