CN1377260A - 抑制淀粉样蛋白沉积的方法和化合物 - Google Patents
抑制淀粉样蛋白沉积的方法和化合物 Download PDFInfo
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- CN1377260A CN1377260A CN00810720A CN00810720A CN1377260A CN 1377260 A CN1377260 A CN 1377260A CN 00810720 A CN00810720 A CN 00810720A CN 00810720 A CN00810720 A CN 00810720A CN 1377260 A CN1377260 A CN 1377260A
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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Abstract
Description
化合物 | 活性 |
3-(3-羟基-1-丙基)氨基-1-丙磺酸 | 有活性 |
DL-2-氨基-5-磷酸戊酸 | 有活性 |
1,2,3,4-四氢异喹啉盐酸盐 | 有活性 |
环己基氨基磺酸钠盐 | 有活性 |
O-磷酸-L-丝氨酸 | 有活性 |
六氟戊二酸 | 有活性 |
8-甲氧基-5-喹啉磺酸钠盐 | 有活性 |
4-苯基-1-(3’-磺基丙基)-1,2,3,6-四氢吡啶钠盐 | 有活性 |
3-氨基-2-羟基-1-丙磺酸 | 有活性 |
3-二甲基氨基-1-丙磺酸 | 有活性 |
Claims (31)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13554599P | 1999-05-24 | 1999-05-24 | |
US60/135,545 | 1999-05-24 | ||
US14312399P | 1999-07-09 | 1999-07-09 | |
US60/143,123 | 1999-07-09 | ||
US09/576,677 US6562836B1 (en) | 1999-05-24 | 2000-05-23 | Methods and compounds for inhibiting amyloid deposits |
US09/576,677 | 2000-05-23 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2008101498521A Division CN101396352A (zh) | 1999-05-24 | 2000-05-24 | 抑制淀粉样蛋白沉积的方法和化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1377260A true CN1377260A (zh) | 2002-10-30 |
CN100435785C CN100435785C (zh) | 2008-11-26 |
Family
ID=27384726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008107203A Expired - Fee Related CN100435785C (zh) | 1999-05-24 | 2000-05-24 | 抑制iapp的化合物或其可药用酯或其可药用盐的制药应用 |
Country Status (13)
Country | Link |
---|---|
US (3) | US6562836B1 (zh) |
EP (1) | EP1227803B1 (zh) |
JP (1) | JP2003500350A (zh) |
CN (1) | CN100435785C (zh) |
AT (1) | ATE466571T1 (zh) |
AU (1) | AU4905000A (zh) |
CA (2) | CA2684016A1 (zh) |
DE (1) | DE60044365D1 (zh) |
HK (1) | HK1050133A1 (zh) |
IL (3) | IL146681A0 (zh) |
MX (1) | MXPA01011989A (zh) |
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WO (1) | WO2000071101A2 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101597196A (zh) * | 2003-06-23 | 2009-12-09 | 贝卢斯健康(国际)有限公司 | 改进的候选药物及其制备方法 |
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Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
KR20070094996A (ko) * | 1999-04-28 | 2007-09-27 | 뉴로겜 인터내셔널 리미티드 | 아밀로이드증 치료용 조성물 및 방법 |
US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
EP1237547A2 (en) * | 1999-07-09 | 2002-09-11 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
WO2003029169A2 (en) | 2001-10-04 | 2003-04-10 | Elan Pharmaceuticals, Inc. | Hydroxypropylamines |
CN1293042C (zh) * | 2002-02-07 | 2007-01-03 | 远藤仁 | 芳香族氨基酸衍生物及其药物组合物 |
AU2003303141A1 (en) | 2002-04-30 | 2004-07-22 | Elan Pharmaceuticals, Inc. | Hydroxypropyl amides for the treatment of alzheimer's disease |
DK1511710T3 (en) * | 2002-05-31 | 2014-02-24 | Proteotech Inc | RELATIONSHIPS, PREPARATIONS AND METHODS FOR TREATING AMYLOID DISEASES AND SYNUCLEINOPATHES, SUCH AS ALZHEIMER'S DISEASE, TYPE 2-DIABETES AND PARKINSON'S DISEASE |
US20040167183A1 (en) * | 2003-02-20 | 2004-08-26 | The Procter & Gamble Company | Phenethylamino sulfamic acids |
US20040204383A1 (en) * | 2003-04-11 | 2004-10-14 | Gabor Tigyi | Lysophosphatidic acid analogs and inhibition of neointima formation |
WO2004113275A2 (en) * | 2003-06-23 | 2004-12-29 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
US7253306B2 (en) * | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
SI1646659T1 (sl) * | 2003-06-23 | 2014-07-31 | Kiacta Sarl | Postopek za pripravo spojin 1,3-propan disulfonske kisline |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20080004211A1 (en) * | 2004-02-23 | 2008-01-03 | Paul Fraser | Inhibitors of Amyloid Fibril Formation and Uses Thereof |
WO2006020049A2 (en) | 2004-07-15 | 2006-02-23 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
MX2007005507A (es) * | 2004-11-12 | 2008-03-13 | Neurochem Int Ltd | Metodos y composiciones fluoradas para el tratamiento de padecimientos relacionados con amiloides. |
WO2006059245A2 (en) * | 2004-11-16 | 2006-06-08 | Neurochem (International) Limited | Compounds for the treatment of cns and amyloid associated diseases |
CN101128421A (zh) * | 2004-12-22 | 2008-02-20 | 神经化学(国际)有限公司 | 治疗淀粉样相关疾病用的方法与组合物 |
WO2006110477A2 (en) * | 2005-04-07 | 2006-10-19 | Astrum Therapeutics Pty. Ltd. | Compounds to treat amyloidosis and prevent death of beta-cells in type 2 diabetes mellitus |
EP1874285B1 (en) * | 2005-04-07 | 2009-10-07 | Astrum Therapeutics Pty, Ltd. | Complementary compositions to reduce blood glucose levels and treat diabetes |
TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
JP2008545663A (ja) * | 2005-05-27 | 2008-12-18 | クイーンズ ユニバーシティ アット キングストン | タンパク質フォールディング障害の治療 |
WO2007023389A2 (en) * | 2005-07-21 | 2007-03-01 | Neurochem (International) Limited | Polymorphic forms of 3-amino-1-propanesulfonic acid |
WO2007125385A2 (en) * | 2005-12-22 | 2007-11-08 | Neurochem (International) Limited | Treatment of renal disorders, diabetic nephopathy and dyslipidemias |
US8748656B2 (en) | 2006-10-12 | 2014-06-10 | Bhi Limited Partnership | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
EP2101772B1 (en) * | 2006-12-06 | 2012-04-25 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
US20080262088A1 (en) * | 2006-12-22 | 2008-10-23 | Wendy Hauck | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
EP2349988A4 (en) * | 2008-11-14 | 2012-05-02 | Bellus Health Inc | ORGANIC NUTRIENT SALTS, PREPARATION METHODS AND USES THEREOF |
US8592451B2 (en) | 2009-03-17 | 2013-11-26 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
DK2429296T3 (en) * | 2009-05-12 | 2018-03-12 | Albany Molecular Res Inc | 7 - ([1,2,4,] TRIAZOLO [1,5, -A] PYRIDIN-6-YL) -4- (3,4-DICHLORPHENYL) -1,2,3,4- TETRAHYDROISOQUINOLINE AND USE thereof |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
KR20120034644A (ko) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
IN2012DN00352A (zh) * | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
EP2464626A4 (en) | 2009-08-10 | 2015-12-16 | Bhi Ltd Partnership | PROCESSES, COMPOUNDS AND COMPOSITIONS FOR THE EXPORTS OF 1,3-PROPANE-SULFONIC ACID |
CN102573794B (zh) | 2009-08-19 | 2017-03-15 | 康奈尔大学 | 供生理注射用的半胱氨酸 |
WO2011156389A2 (en) * | 2010-06-07 | 2011-12-15 | The Regents Of The University Of California | The islet amyloid polypeptide toxic oligomer is a biomarker of heart or kidney failure in type-2 diabetes mellitus |
EP2605694B1 (en) * | 2010-08-16 | 2021-10-27 | Cognoptix, Inc. | Method for detecting amyloid proteins |
EP2714682B1 (en) | 2011-05-24 | 2016-03-16 | Università degli Studi di Bari "Aldo Moro" | Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases |
EP2785346A4 (en) | 2011-11-30 | 2015-04-29 | Bikam Pharmaceuticals Inc | OPSINBINDING LIGANDS, COMPOSITIONS THEREOF, AND METHOD OF USE THEREOF |
CN105636586B (zh) * | 2013-10-03 | 2018-05-29 | 库拉肿瘤学公司 | Erk抑制剂及使用方法 |
WO2016196591A1 (en) * | 2015-06-01 | 2016-12-08 | Indiana University Research & Technology Corporation | Protein tyrosine phosphatases or shp2 inhibitors and uses thereof |
WO2018009854A1 (en) * | 2016-07-08 | 2018-01-11 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Indoline derivatives and method for using and producing the same |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3872125A (en) | 1973-03-03 | 1975-03-18 | Sandoz Ag | 3-substituted-4-aryl isoquinolines |
FR2384751A1 (fr) | 1977-03-23 | 1978-10-20 | Francaise Coop Pharma | Nouveaux derives de la taurine a activite neuro-musculaire renforcee |
CA1140049A (en) | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
FR2457281A1 (fr) | 1979-05-23 | 1980-12-19 | Meram Lab | Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee |
US4540564A (en) | 1982-05-18 | 1985-09-10 | University Of Florida | Brain-specific drug delivery |
US5087618A (en) | 1982-05-18 | 1992-02-11 | University Of Florida | Redox carriers for brain-specific drug delivery |
FR2529546A1 (fr) | 1982-07-05 | 1984-01-06 | Meram Lab | Nouveaux sels d'amino-(et imino-)acides a, o-sulfoniques n-substitues, vecteurs cationiques de haute penetration cellulaire |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
IT1193590B (it) | 1983-01-07 | 1988-07-08 | Loris Jacopo Bononi | Derivati amino-alchil-solfonici,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
FR2595356B1 (fr) | 1986-03-05 | 1991-05-24 | Pasteur Strasbourg Universite | Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications |
SE454299B (sv) * | 1986-10-08 | 1988-04-18 | Westermark P | Sats innehallande polypeptid som finns i pankreasoamyloid och/eller antikroppar riktade mot polypeptiden |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
DE3940410A1 (de) | 1989-12-04 | 1991-06-06 | Schering Ag | Neue verwendung von nmda-rezeptor-antagonisten |
FR2657164B1 (fr) | 1990-01-16 | 1992-04-03 | Cit Alcatel | Installation de detection de fuite a pompe holweck a prise intermediaire. |
US5242932A (en) | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
US5385915A (en) | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
DE4021066A1 (de) | 1990-07-03 | 1992-01-09 | Hoechst Ag | Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden |
JPH06502184A (ja) | 1991-02-22 | 1994-03-10 | シャピロ,ハワード ケイ. | 神経性疾病の症候や原因上関係のある症候の治療のための薬用化合物の使用 |
US5164295A (en) | 1991-03-06 | 1992-11-17 | The Upjohn Company | Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds |
IT1245907B (it) * | 1991-05-17 | 1994-10-25 | Alfa Wassermann Spa | Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. |
US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
EP0611966A1 (en) * | 1993-02-19 | 1994-08-24 | Bayer Corporation | Method, composition and device for measuring the ionic strength or specific gravity of a test sample |
EP0691844A1 (en) | 1993-03-29 | 1996-01-17 | Queen's University At Kingston | Method for treating amyloidosis |
US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
US5840294A (en) | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
DE4313118A1 (de) | 1993-04-22 | 1994-10-27 | Hoechst Ag | Verwendung von 1,2,3,4-Tetrahydroisochinolin-Derivaten als Antimykotika |
AU6836394A (en) | 1993-06-01 | 1994-12-20 | Cortex Pharmaceuticals, Inc. | Use of metabotropic receptor agonists in progressive neurodegenerative deseases |
US5576419A (en) * | 1993-06-30 | 1996-11-19 | Regents Of The University Of Minnesota | Mild solid-phase synthesis of aligned branched triple-helical peptides |
WO1995006477A1 (en) | 1993-08-31 | 1995-03-09 | Gliatech, Inc. | Inhibition of beta amyloid binding to glycosaminoglycans for treatment of alzheimer's disease |
US6187991B1 (en) | 1995-05-23 | 2001-02-13 | Pfizer Inc | Transgenic animal models for type II diabetes mellitus |
US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
WO1997007402A1 (en) | 1995-08-17 | 1997-02-27 | The Ontario Cancer Institute | Protein fibril assembly assay |
WO1997009976A2 (en) | 1995-09-01 | 1997-03-20 | Washington University | Method of reducing neurotoxic injury with zinc chelators |
JPH0995444A (ja) * | 1995-10-02 | 1997-04-08 | Teijin Ltd | アミロイド蛋白凝集阻害剤 |
AU7456396A (en) | 1995-11-02 | 1997-05-22 | Warner-Lambert Company | Inhibition of amyloidosis by 9-acridinones |
AU703540B2 (en) | 1996-03-26 | 1999-03-25 | Meddiss, Incorporated | Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general |
US6043283A (en) | 1996-09-20 | 2000-03-28 | Baylor College Of Medicine | Tyramine compounds and their neuronal effects |
US5927328A (en) * | 1996-09-26 | 1999-07-27 | Masco Corporation | Self closing faucet with timing mechanism |
PL332413A1 (en) | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
SE9604582D0 (sv) | 1996-12-13 | 1996-12-13 | Astra Ab | Novel compounds |
US5869469A (en) | 1997-08-18 | 1999-02-09 | Queen's University At Kingston | Phosphonocarboxylate compounds for treating amyloidosis |
EP1014994A1 (en) * | 1997-08-18 | 2000-07-05 | Queen's University At Kingston | Phosphono-carboxylate compounds for treating amyloidosis |
ES2200366T3 (es) * | 1997-08-28 | 2004-03-01 | University Of Washington | Composiciones de sacaridos para el tratamiento de la enfermedad de alzheimer y otras amiloidoisis. |
US5952389A (en) | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
US6166320A (en) * | 1998-03-19 | 2000-12-26 | Toyota Jidosha Kabushiki Kaisha | Tandem solar cell |
US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
WO2000057707A1 (en) | 1999-03-15 | 2000-10-05 | Proteotech, Inc. | Methods of treating alzheimer's disease and other amyloidoses using hypericum perforatum and derivatives thereof |
KR20070094996A (ko) | 1999-04-28 | 2007-09-27 | 뉴로겜 인터내셔널 리미티드 | 아밀로이드증 치료용 조성물 및 방법 |
US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
EP1237547A2 (en) | 1999-07-09 | 2002-09-11 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
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2000
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101597196A (zh) * | 2003-06-23 | 2009-12-09 | 贝卢斯健康(国际)有限公司 | 改进的候选药物及其制备方法 |
CN101597196B (zh) * | 2003-06-23 | 2016-05-04 | 基亚克塔有限公司 | 改进的候选药物及其制备方法 |
CN115361866A (zh) * | 2020-03-31 | 2022-11-18 | 株式会社Lg化学 | 用于保护胰岛移植的组合物 |
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NZ566739A (en) | 2009-10-30 |
CN100435785C (zh) | 2008-11-26 |
WO2000071101A3 (en) | 2001-12-06 |
JP2003500350A (ja) | 2003-01-07 |
EP1227803B1 (en) | 2010-05-05 |
NZ552354A (en) | 2008-04-30 |
CA2684016A1 (en) | 2000-11-30 |
ATE466571T1 (de) | 2010-05-15 |
EP1227803A2 (en) | 2002-08-07 |
US20080227767A1 (en) | 2008-09-18 |
US7393875B2 (en) | 2008-07-01 |
IL146681A0 (en) | 2002-07-25 |
US7786174B2 (en) | 2010-08-31 |
CA2373093C (en) | 2010-01-19 |
HK1050133A1 (zh) | 2003-06-13 |
DE60044365D1 (de) | 2010-06-17 |
IL146681A (en) | 2007-12-03 |
US20040248876A1 (en) | 2004-12-09 |
US6562836B1 (en) | 2003-05-13 |
NZ541238A (en) | 2007-02-23 |
AU4905000A (en) | 2000-12-12 |
WO2000071101A2 (en) | 2000-11-30 |
IL180523A0 (en) | 2009-02-11 |
CA2373093A1 (en) | 2000-11-30 |
MXPA01011989A (es) | 2002-05-06 |
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