CN1389722A - Spatial multichannel fiber coupler with laser induced synchronous fluorescence detection - Google Patents
Spatial multichannel fiber coupler with laser induced synchronous fluorescence detection Download PDFInfo
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- CN1389722A CN1389722A CN 02136100 CN02136100A CN1389722A CN 1389722 A CN1389722 A CN 1389722A CN 02136100 CN02136100 CN 02136100 CN 02136100 A CN02136100 A CN 02136100A CN 1389722 A CN1389722 A CN 1389722A
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Abstract
A fiber coupler for synchronous test of spatial multi-channel aser adjust fluorescence inclues a laser beam coupled into an exciting fiber with equal power via a beam split mirror and a focussing lens. The output terminal of the exciting fiber is surrounded by exciting collect probes grouped by equal quantity of fluorescent collect fibers and housed with positioning liners. The fluorescent collect fibers in linear array are put in the liner diaphragm and aligned with the slit of spectrometer with a photoelectric transducer on its exit focus surface. This invention can guarantee the same test conditions for laser adjust fluorescent test spots with different spaces including same density of exciting light energy of the test spots, same fluorescent collect spatial angles and same fluorescent spectrom density with same samples.
Description
Technical field:
The present invention relates to a kind of fiber coupling device, relate in particular to a kind of fiber coupling device of spatial multichannel laser-induced fluorescence (LIF) synchronous detection, be used for detecting simultaneously the laser-induced fluorescence spectroscopy of different samples, belong to optical technical field.
Background technology:
At present, the laser-Induced Fluorescence Detection technology detects at material, aspect the material component analysis, especially being widely used aspect biomedical diagnostic.Laser-Induced Fluorescence Detection is meant: with the laser radiation material sample of ultraviolet light wave band or visible light wave range, some material sample can send the fluorescent radiation of wavelength greater than incident laser, its fluorescence spectral characteristic reflects the level structure of material, therefore can be used as a kind of means of species analysis.Often run into the situation that once to gather the multiple spot fluorescence spectrum in actual applications.Biological example body different parts detects the absorbing state of injecting body fluorescence class medicine; In the middle of the clinical and fundamental research of early diagnosis of cancer and optical dynamic therapy, need detect the laser-induced fluorescence (LIF) spectrum of human body normal structure and abnormal structure simultaneously, so that compare differentiation.Existing laser-Induced Fluorescence Detection device is generally: the exciting light of laser instrument output shine a certain sample or sample by optical coupling system certain a bit, the fluorescence that sample sends is gathered optical fiber (one or a branch of) by fluorescence and is transmitted and be coupled into spectrometer, and incident beam is noted down fluorescence spectrum by photoelectric sensor (for example photodiode, photomultiplier, snowslide pipe or CCD etc.) after the beam split in spectrometer.Because this device can only detect the fluorescence Spectra of a point at synchronization, can not satisfy the actual needs that multiple spot is gathered, its application is restricted.
Summary of the invention:
The objective of the invention is at the deficiencies in the prior art, a kind of fiber coupling device of spatial multichannel laser-induced fluorescence (LIF) synchronous detection is provided, fluorescent material is synchronous with reference to the detection problem in the dynamic processes such as solution biology, medical science and chemical reaction, not only the fluorescence spectrum of test sample simultaneously can also improve accuracy of detection and efficient.
To achieve these goals, the fiber coupling device of the present invention's design has adopted the spatial multichannel laser-induced fluorescence (LIF) to gather optical fiber structure, with common non-imaging-type spectrometer, cooperate the measurement mechanism that composition can carry out fluoroscopic examination simultaneously to two or more different points with linear array or face array photoelectric sensor (for example CCD or ICCD) etc.The present invention is divided into three parts by function: exciting light coupling unit, probe segment and fluorescence are gathered coupling unit.
At the exciting light coupling unit, adopt light beam splitter and condenser lens, the excitation beam that laser instrument is exported is separated into the light beam that several Shu Guangqiang equate, and is coupled to the input end of many excitation fiber respectively.Exciting the acquisition probe part, evenly around the fluorescence collection optical fiber of quantity such as arrangement, end surface grinding is light smoothly around each root excitation fiber, and the outside is overlapped with abutment sleeve.Gather coupling unit at fluorescence, the output beam of respectively fluorescence being gathered optical fiber is arranged in linear array, is coupled into spectrograph slit, and each bundle optical fiber all adds the upper bush diaphragm and aims at spectrograph slit in coupled end.Adjust the axial location of optical fiber in the sleeve diaphragm, make fluorescence on the detection focal plane, longitudinally promptly separate fully, reach the purpose that space fluorescence separates with the slit parallel direction.Place the photoelectric sensor surveyed on the focal plane that the fluorescence spectrum of zones of different is detected implementation space multiple spot fluorescence synchronous detection.
The invention has the beneficial effects as follows, the test condition that can guarantee the laser-induced fluorescence (LIF) measurement point that the space is different simultaneously is identical, comprises that the exciting light energy density of measurement point is identical, fluorescence collection space multistory angle fluorescence spectrum intensity identical and under the same sample condition is identical.Thus can be under the shooting conditions of sample and fluorescence acquisition condition and the identical situation of detection system the fluorescence spectrum of test sample simultaneously, by the different fluorescence spectrum information of the sample that obtains, reflect the property difference of sample itself.The present invention has effectively improved the degree of accuracy and the accuracy of testing result, improves detection efficiency, reduces sample size, reduces cost, and can realize that the characteristic parameter of single sample is measured.
The present invention can solve the synchronous with reference to the detection problem of fluorescent material in the dynamic processes such as biology, medical science and chemical reaction.For example, device of the present invention can detect the fluorescence Spectra at normal position of same patient skin and unusual position simultaneously in the early diagnosis of cutaneum carcinoma laser-induced fluorescence (LIF) is used, by the reference comparative analysis, obtain diagnostic result.The Error Diagnostics of having avoided the specificity of Different Individual to bring, thus also avoided traditional single sense channel probe timesharing to measure the stochastic error that bring the test condition change to cause.
Description of drawings:
Fig. 1 is the one-piece construction synoptic diagram of fiber coupling device of the present invention (triple channel).
As shown in Figure 1, apparatus of the present invention are made up of three parts, comprise the exciting light coupling unit, excite acquisition probe part and fluorescence to gather coupling unit.Wherein, the different light beam splitter 2,3 of 1, two optical maser wavelength transmitance of laser instrument, condenser lens 4, excitation fiber 5 excites acquisition probe 6, abutment sleeve 7, detect sample 8, gather fibre bundle 9, sleeve diaphragm 10, gather optical fiber and adjust sleeve 11, spectrograph slit 12, photoelectric sensor 13, exposure pixel area 14.
Fig. 2 excites the acquisition probe structural representation in apparatus of the present invention.
Fig. 3 is that the fluorescence in apparatus of the present invention is gathered the coupling unit structural representation.
Embodiment:
Below in conjunction with the drawings and specific embodiments technical scheme of the present invention is described further.
As shown in Figure 1, apparatus of the present invention comprise the exciting light coupling unit, excite acquisition probe part and fluorescence to gather coupling unit.The function of exciting light coupling unit is the laser that produces luminous powers such as three beams, and is coupled in the excitation fiber respectively.The laser beam luminous power of laser instrument 1 output is P
0, at beam splitter 2 (T
2=33.3%) punishment is two bundles, and beam splitter plane and laser beam angle are 45 °, and the luminous power of transmission is P
0/ 3, folded light beam is at beam splitter 3 (T
3=50%) punishment is two bundles.The luminous power of the three-beam that process beam splitter 2 and beam splitter 3 beam splitting obtain equates, is P
0/ 3.Three-beam is coupled into quartzy excitation fiber 5 with condenser lens 4 respectively.
Among the present invention, the transmitance T of light beam splitter and reflectivity R sum are 1.
For different numbers of channels, the transmitance of light beam splitter can be calculated according to following formula
T
i+2＝1/(n-i) i＝0，1…n-2
Wherein n is a number of channels, and light beam splitter label is right among the following footnote sequence number of transmitance T and Fig. 1
Should.
The function that excites the acquisition probe part is the laser excitation sample with excitation fiber output, and the phosphor collection of sample generation is got up, and gathers Optical Fiber Transmission by fluorescence and gathers coupling unit to fluorescence.Its structure as shown in Figure 2.Uniform ring sticks with glue knot and fixes around gathering optical fiber 9 around the excitation fiber 5, and end surface grinding is light smoothly, forms to excite acquisition probe 6.Pop one's head in 6 overcoats with abutment sleeve 7, play adjustment and excite the end face of gathering optical fiber 9 to sample 8 distances.The fluorescence that the ultraviolet light that excitation fiber 5 transmits produces after sample 8 place's excite tissue is coupled into spectrometer through gathering optical fiber 9 transmission.
The function that fluorescence is gathered coupling unit is that fluorescent is carried out space and spectrum bidimensional spectroscopy, and structure as shown in Figure 3.Gather optical fiber 9 for every group and line up linear array, insert collection optical fiber adjustment sleeve 11 and bonding wherein, gather optical fiber adjustment sleeve 11 outsides and overlap, make the optical fiber align spectrograph slit 12 that is arranged in linear array with sleeve diaphragm 10.Along the distance that is parallel between the slit direction adjustment sleeve diaphragm 10, and along the sleeve axis direction, adjustment is gathered optical fiber and is adjusted the position of sleeve 11 in sleeve diaphragm 10, and three groups of exposure pixel areas 14 strictnesses that are positioned on the focal plane photoelectric sensor 13 are separated.
The key condition that apparatus of the present invention are effectively implemented is: 1. the exciting light energy density of the different test points in space is identical; 2. it is identical with respect to the locus of test point to gather fiber end face; 3. satisfying 1. and 2. under the condition, for the different test points of same sample, the spectral signal intensity that photoelectric sensor is gathered is identical with shape.
For reaching condition requirement 1., can measure Output optical power with light power meter at the other end of excitation fiber 5 by adjusting 2,3 and three condenser lenses 4 of light beam splitter among Fig. 1, the luminous power of three output terminals is equated; In addition, adjust abutment sleeve 7, make three output terminals of excitation fiber equal to the distance of test sample face.Because the excitation fiber of using is identical, and same numerical aperture is arranged, therefore, the bright spot size of illumination that is excited on the sample is identical, and promptly the exciting light energy density of tested pilot is identical.
2. condition will lean on the optical cable crudy to guarantee, collection optical fiber 9 is arranged in around the excitation fiber 5 equably, and end face is all on same plane; Adjust abutment sleeve 7, make three output terminals of excitation fiber equal, guarantee that like this hot spot on the sample has identical three-dimensional subtended angle to gathering fiber end face to the distance of sample face.
Reaching 1. and 2. under the conditional request situation, with three three differences (fluorescence efficiency that requires the standard model difference to point out here is identical) that excite collection head to place same standard model, adjust and gather the axial location of optical fiber adjustment sleeve 11 in sleeve diaphragm 10, make three groups of exposure pixel areas 14 on the photoelectric sensor 13 separately strict, and keep spectral intensity to equate.
During spectral detection,, promptly obtain the intensity of three test points in respective wavelength respectively with the intensity addition of three vertical pixel detecting in zone on the photoelectric sensor 13.Because spectrometer has the branch light action in the horizontal direction, so the three-beam that space (vertically) separates also separates by wavelength in the horizontal direction.
Claims (3)
1, a kind of fiber coupling device of spatial multichannel laser-induced fluorescence (LIF) synchronous detection, it is characterized in that comprising the exciting light coupling, excite acquisition probe and fluorescence collection three parts that are coupled, the laser beam of laser instrument (1) output is through light beam splitter (2,3) obtain the light beam that luminous power equates after the beam splitting, line focus lens (4) are coupled into quartzy excitation fiber (5) respectively, uniform ring is gathered optical fiber (9) around fluorescence around excitation fiber (5) output terminal, form and excite acquisition probe (6), probe (6) overcoat is with abutment sleeve (7), gather optical fiber (9) for every group and line up linear array, insert and gather in the optical fiber adjustment sleeve (11), the outside cover makes with sleeve diaphragm (10) and gathers optical fiber (9) aligning spectrograph slit (12), places photoelectric sensor (13) on the spectrometer emergent light focal plane.
2,, it is characterized in that the transmitance of light beam splitter (2,3) is respectively T as the fiber coupling device of the said spatial multichannel laser-induced fluorescence (LIF) of claim 1 synchronous detection
2=33.3%, T
3=50%, its plane and laser beam angle are 45 °, and the laser beam luminous power of laser instrument (1) output is P
0, the luminous power that process light beam splitter (2) and light beam splitter (3) obtain is P
0/ 3.
3,, it is characterized in that the transmitance T of light beam splitter (2,3) and reflectivity R sum are 1 as the fiber coupling device of the said spatial multichannel laser-induced fluorescence (LIF) of claim 1 synchronous detection.
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| CN100343655C (en) * | 2004-06-18 | 2007-10-17 | 中国科学院上海有机化学研究所 | Online self-calibration laser induced fluorescence detection method based on electric charge coupling apparatus |
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| CN102539392A (en) * | 2011-12-21 | 2012-07-04 | 北京农业信息技术研究中心 | System and method for on-line detection of nitrogen in farmland soil |
| CN103338068A (en) * | 2013-06-28 | 2013-10-02 | 华中科技大学 | Light splitting monitoring device based on multi-channel parallel optical signals |
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| CN104614351A (en) * | 2015-01-21 | 2015-05-13 | 南京中科神光科技有限公司 | Rapid and multi-channel real-time fluorescence quantification detection device |
| CN105527263A (en) * | 2016-01-15 | 2016-04-27 | 公安部第一研究所 | Optical fiber beam splitting method and device for laser-induced fluorescent light path |
| CN105527274A (en) * | 2016-01-29 | 2016-04-27 | 华中科技大学 | Efficient multipath laser probe analysis system and method |
| CN106248639A (en) * | 2016-06-20 | 2016-12-21 | 环境保护部华南环境科学研究所 | Multichannel nitrogen oxides on-line monitoring system based on laser-induced fluorescence (LIF) |
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