CN1507340A - 用于使牙齿表面变白的条 - Google Patents
用于使牙齿表面变白的条 Download PDFInfo
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- CN1507340A CN1507340A CNA028095774A CN02809577A CN1507340A CN 1507340 A CN1507340 A CN 1507340A CN A028095774 A CNA028095774 A CN A028095774A CN 02809577 A CN02809577 A CN 02809577A CN 1507340 A CN1507340 A CN 1507340A
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 34
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 20
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920000642 polymer Polymers 0.000 claims abstract description 14
- 239000011159 matrix material Substances 0.000 claims abstract description 10
- 150000002978 peroxides Chemical class 0.000 claims abstract description 9
- 210000003296 saliva Anatomy 0.000 claims abstract description 7
- 239000007787 solid Substances 0.000 claims abstract description 7
- 210000000214 mouth Anatomy 0.000 claims abstract description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 239000004014 plasticizer Substances 0.000 claims description 9
- 230000036571 hydration Effects 0.000 claims description 6
- 238000006703 hydration reaction Methods 0.000 claims description 6
- 239000007844 bleaching agent Substances 0.000 claims description 5
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 4
- 229940045872 sodium percarbonate Drugs 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 239000010408 film Substances 0.000 description 39
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 12
- 239000010410 layer Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 10
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- 229910001573 adamantine Inorganic materials 0.000 description 8
- 239000000463 material Substances 0.000 description 8
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- 239000001913 cellulose Substances 0.000 description 4
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 229910001919 chlorite Inorganic materials 0.000 description 3
- 229910052619 chlorite group Inorganic materials 0.000 description 3
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 3
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- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 2
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- 229960002218 sodium chlorite Drugs 0.000 description 2
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 239000004343 Calcium peroxide Substances 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241001354782 Nitor Species 0.000 description 1
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- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- WOHVONCNVLIHKY-UHFFFAOYSA-L [Ba+2].[O-]Cl=O.[O-]Cl=O Chemical compound [Ba+2].[O-]Cl=O.[O-]Cl=O WOHVONCNVLIHKY-UHFFFAOYSA-L 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- QXIKMJLSPJFYOI-UHFFFAOYSA-L calcium;dichlorite Chemical compound [Ca+2].[O-]Cl=O.[O-]Cl=O QXIKMJLSPJFYOI-UHFFFAOYSA-L 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- KAGBQTDQNWOCND-UHFFFAOYSA-M lithium;chlorite Chemical compound [Li+].[O-]Cl=O KAGBQTDQNWOCND-UHFFFAOYSA-M 0.000 description 1
- NWAPVVCSZCCZCU-UHFFFAOYSA-L magnesium;dichlorite Chemical compound [Mg+2].[O-]Cl=O.[O-]Cl=O NWAPVVCSZCCZCU-UHFFFAOYSA-L 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
Abstract
一种薄而柔软的膜，当被施加到染污的牙齿上时，该膜由唾液水合并以这样的形式有效地使牙齿变白，该膜包括无水的、可水合的环氧乙烷聚合物基体，该基体包含固体过氧化物变白剂，由此一旦被施加到染污的牙齿表面，当在牙齿上布置和放置膜时，过氧化物变白剂就由口腔中存在的唾液溶解成为活性的变白活度。
Description
发明领域
本发明一般涉及用于使人类牙齿变白的体系，更具体地涉及用于向牙齿施加变白剂，从其表面除去染污的条。
发明背景
现有技术
牙齿由内部牙本质层和外部硬的牙釉质层组成，牙釉质层是牙齿的保护层。牙齿的牙釉质层天然地是不透明白色或略微黄白色。正是此牙釉质层可被染污或变色。牙齿的牙釉质层由羟磷灰石无机晶体组成，该晶体一定程度上产生多孔表面。相信牙釉质层的此多孔性是使染污和变色物质渗透牙釉质层和使牙齿变色的原因。
人们在日常生活中面对或与之接触的许多物质可“染污”人们的牙齿或降低人们牙齿的“白度”。特别地，人们消费的食品、烟草产品和流体如茶和咖啡倾向于染污人们的牙齿。这些产品或物质容易聚积在牙釉质上，在牙齿上形成一层膜这些染污和变色物质则可渗透牙釉质层。此问题在许多年内逐渐发生，但会使人们的牙齿牙釉质发生显著变色。
本领域已知使牙齿变白的措施包括通过刷牙，向牙齿施涂US5,256,402和US5,814,309中公开的含过氧化物的牙膏组合物。
近来人们可以购到各种非处方的牙齿变白体系，包括由塑料膜的薄条组成的变白体系，该塑料膜含有施加到其表面上的如US5,894,017、US5,891,453和6,045,811中描述的牙齿变白组合物。尽管当被施加到被染污的牙齿上时，这些体系产生变白效果，但本领域仍然在寻找新体系以改进和提高牙齿变白度。
发明概述
本发明提供一种用于施加含药剂的组合物以使牙齿的染污表面变白的体系，其中提供了一种能够粘合到潮湿牙齿表面的薄膜，该薄膜包括干燥的、由一种或多种环氧乙烷聚合物组成的可水合基体，和水溶性增塑剂，基体其中含有以有效用量引入的固体水溶性变白剂，该变白剂当由口腔中的唾液溶解而从膜中释放时，可以使施加膜的牙齿变白。
优选实施方案的描述
本发明的可水合聚环氧乙烷可以制成约20-约1500微米(μm)，优选约50-约1000μm的厚度。干燥膜包含非活性状态的固体过氧化物变白剂。由口腔中唾液的膜水合溶解环氧乙烷聚合物基体中引入的水溶性固体变白剂，由此将变白剂活化和释放到施加膜的牙齿上。
通过改变膜厚度、聚合物性能以及变白剂浓度可控制变白剂溶解和其后释放出来与牙齿表面接触的速率，该浓度一般为膜的约0.1wt％-约30wt％和优选约0.5wt％-约25wt％。
适于本发明实施的固体变白剂包括过氧化物、金属亚氯酸盐、过硼酸盐、过碳酸盐、过氧酸、过硫酸盐及其组合。合适的过氧化物化合物包括过氧化氢、过氧化脲、过氧化钙及其混合物。合适的金属亚氯酸盐包括亚氯酸钙、亚氯酸钡、亚氯酸镁、亚氯酸锂、亚氯酸钠和亚氯酸钾。优选的亚氯酸盐是亚氯酸钠。优选的过碳酸盐是过碳酸钠。优选的过硫酸盐是过硫酸氢钾制剂。
用于本发明目的的环氧乙烷聚合物包括分子量可在约10,000-约10,000,000道尔顿的范围内变化，优选约100,000-约1,500,000道尔顿的环氧乙烷聚合物的均聚物或混合物。这样的环氧乙烷聚合物可从各种来源购得。分子量为10,000-1,000,000道尔顿的聚环氧乙烷以商品名“Polyox”购自Union Carbide Company和优选用于本发明的目的。环氧乙烷聚合物构成本发明膜的约50wt％-约95wt％和优选约60wt％-约85wt％。
用于本发明目的的增塑剂选自二醇如丙二醇、聚乙二醇，多元醇如甘油和山梨醇和甘油酯如三乙酸甘油酯。增塑剂构成本发明膜的约5-约30wt％和优选约10-约25wt％。
甘油是用于本发明的优选增塑剂，以及如以它们的Carbowaxes系列购自Union Carbide Company的丙二醇或聚乙二醇，它们的分子量为200-600道尔顿。
除引入过氧化物变白剂和增塑剂以外，在膜基体中也可以包括少量，如0.01-2wt％的组分如抗氧剂、防腐剂、香料和着色剂。
也可以采用如10纳米(nm)-500微米(μm)厚度的薄保护性涂料层来涂敷环氧乙烷聚合物膜的一侧，该涂料层用作防止溶解的变白剂从基体中释放到口腔粘膜的屏蔽，由此达到变白剂仅在牙齿表面上的单向释放。
以足够薄的层涂敷涂料材料，以不影响的柔韧性和使变白条适应于一排牙齿的排列。
涂料材料可以是高分子量物质(即分子量大于1,000,000道尔顿)的一种或其组合并且包括，乙基纤维素、丙基纤维素、异丙基纤维素、丁基纤维素、叔丁基纤维素、乙酸纤维素和聚乙烯醇的衍生物如聚乙酸乙烯酯和虫胶。
可以使用常规挤出或溶剂流延方法制备本发明的环氧乙烷聚合物膜。例如，为通过溶剂流延聚环氧乙烷以制备膜，将环氧乙烷聚合物或聚合物混合物溶于足够量与聚合物相容的溶剂中。合适溶剂的例子包括水、醇、丙酮、乙酸乙酯或其混合物。在形成溶液之后，采用搅拌加入增塑剂，如需要，施加热量以协助溶解，直到形成透明和均匀的溶液，随后加入变白剂和任何其它组分如香料。将溶液涂敷到合适的载体材料上和干燥以形成膜。载体材料必须具有表面张力，该表面张力允许聚合物溶液平坦地在所需的载体宽度上铺展而不浸入，在两种基材之间形成破坏性键。合适载体材料的例子包括玻璃、不锈钢、特氟隆、聚乙烯浸渍的牛皮纸。
可以在高温空气浴中使用干燥箱、烘道、真空干燥器或任何其它合适的干燥设备进行膜的干燥，该设备不会对膜的活性组分或香料产生不利影响。
为了容易使用，将干燥膜切割成合适尺寸和形状和装入合适的容器中。
为使用本发明的变白膜条，当被施加到牙齿表面上时，当由口腔中的唾液水合或在水中浸渍而预润湿时，膜会以适当的方式粘附到牙齿上。这样，变白条就会形成具有适于覆盖一排牙齿(上排或下排)的宽度尺寸。因此，可以将变白条单独施加到上组牙齿上，或施加到下组牙齿上，或者同时进行。变白条的长度尺寸由所需的覆盖用量确定。这样，需要变白的牙齿数目将决定变白条的尺寸。例如，可能仅需要变白前面的牙齿，这些牙齿最容易被他人看见。因此，与需要变白所有牙齿的情况相比，在此情况下可以减少变白条的长度。变白条对牙齿施加的持续时间将取决于变白剂和类型的浓度，以及染污的类型和强度。
由如下实施例说明本发明。
实施例1
在剧烈搅拌下，将10.0克(g)聚环氧乙烷(M.W.200,000，Aldrich)缓慢加入到约85.0g加热到约80℃的去离子水中，以形成半透明和粘性溶液。向此溶液中加入2.5g甘油和搅拌约30分钟。将混合物冷却到40℃以下和将2.4g过碳酸钠粉末加入和充分混合。将获得的白色混合物流延到玻璃板上和让其干燥过夜。形成白色干燥膜，该膜容易从玻璃板剥离。干燥膜的厚度为约160μm和包含膜重量的约3.4％当量的过氧化氢。
通过对染污的牛牙釉质板表面润湿和放置膜片(14mm×15mm，重23毫克(mg))而检验此膜(称为“膜A”)的变白效率，此牙釉质板如在“采用牙膏体外除去染污(In Vitro Removal of Satin withDentifrice)”，G.K.Stookey，T.A.Barkhard和B.R.Schemerhorn，J.Dental Res.61，1236-9(1982)中所述制备和从印地安那大学口腔卫生研究院获得。将一张湿纸巾放置在膜的上面以保持水分。在30分钟之后，将纸巾和残余膜两者除去和采用水洗涤牙齿。在处理之前和之后，采用Minolta型号CR321比色计测量和记录牙齿的暗度，其中“L”是眼睛对亮度和暗度感应的量度，L值越高，牙齿显得越白。
为了进行比较起见，将在US5,894,017中公开的那种包含5.2wt％过氧化氢的市售牙齿变白条(称为“膜B”)，也切割成重40mg的相似尺寸，按照实施例1的程序用于处理相似染污的牛牙釉质板30分钟。在下表I中记录了被膜A和B处理的L值变化数据。
| 表I |
| 膜 重量(mg) H2O2 wt.％ 初始L 最终L dL |
| A 23 3.4 37.32 62.09 24.77B 40 5.2 37.43 44.67 7.24 |
表I中记录的结果显示，根据本发明制备的膜A的变白效率意外地比市售变白条(膜B)的变白效率高得多，尽管其过氧化物的含量明显降低。
实施例2
使用1.0克聚环氧乙烷(M.W.400,000道尔顿)制备一系列膜，在剧烈搅拌下将聚环氧乙烷缓慢加入到约80.0g加热到约80℃的热去离子水中。在保持相同温度的同时继续搅拌，将另10.0克聚环氧乙烷(M.W.200,000道尔顿)缓慢加入到溶液中。在聚环氧乙烷完全溶解之后，形成半透明和粘性溶液/悬浮液。在约80℃下加热和搅拌另两个小时使溶液浓缩。然后将溶液冷却到室温(23℃)。
向以上溶液中加入3.3g甘油和搅拌约30分钟，直到获得均相溶液。随后，将3.0g过碳酸钠粉末加入和与聚环氧乙烷充分混合以形成白色，稠凝胶状悬浮液。
将以上凝胶状悬浮液流延到玻璃板上和在室温(23℃)下干燥过夜制备独立的膜。在干燥之后，形成了膜并可以容易地从玻璃板上剥离。膜是柔软而结实的和可以弯曲或折叠而不会破裂。制备薄和厚两种薄膜。称为“C”的薄膜的厚度为约100μm，包含约2.9wt％过氧化氢。
称为“D”的厚膜的厚度为约500μm，包含约3.4wt％过氧化氢。
通过流延以上制备的聚环氧乙烷悬浮液到软质棉布上和在空气中干燥，制备第三块承载膜。获得的条(称为“膜E”)的过氧化氢含量为承载膜重量的1.5wt％。
使用染污的牛牙釉质板重复实施例I的变白测试程序，以确定膜C、D和E的牙齿变白效率。在处理之前和之后，皆使用Minolta型号CR321比色计来记录牙齿的暗度变化。作为对比，将一条市售变白条(实施例I的膜B)也切割成相似的尺寸和用于处理另一个牛牙齿30分钟。在表II中记录这些测试的结果。
| 表II | ||||
| 膜 | H2O2 wt.％ | 初始L | 最终L | dL |
| C | 2.9 | 28.98 | 47.56 | 18.58 |
| D | 3.4 | 38.28 | 65.21 | 26.93 |
| E | 3.0 | 40.07 | 61.82 | 21.75 |
| B | 4.6 | 33.33 | 41.54 | 8.21 |
与对比市售变白条膜B相比，染污牛牙釉质板与对本发明膜C，D和E接触30分钟之后的暗度显示出优异的变白效率。
Claims (10)
1.一种薄而柔软的膜，当施加到染污的牙齿上时，该膜由唾液水合并以这样的形式有效地使牙齿变白，该膜包括无水的、可水合的环氧乙烷聚合物基体，该基体包含固体过氧化物变白剂，由此一旦施加到染污的牙齿表面，当在牙齿上布置和放置膜时，过氧化物变白剂就由口腔中存在的唾液溶解成为活性的变白活度。
2.权利要求1的膜，其中环氧乙烷聚合物的分子量为约100,000-10,000,000道尔顿。
3.权利要求1的膜，其中环氧乙烷聚合物的分子量为约100,000-1,500,000道尔顿。
4.权利要求1的膜，其中环氧乙烷聚合物构成膜的约50wt％-约95wt％。
5.权利要求1的膜，其中膜包含约0.1wt％-约30wt％的固体变白剂。
6.权利要求1的膜，其中变白剂是过碳酸钠。
7.权利要求1的膜，其中在基体中引入增塑剂。
8.权利要求8的膜，其中增塑剂在基体中以约5.0wt％-约30.0wt％的浓度存在。
9.权利要求8的膜，其中增塑剂是甘油。
10.权利要求1的膜，膜的厚度为约20μm-约1500μm。
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-
2001
- 2001-03-12 US US09/804,530 patent/US6419906B1/en not_active Expired - Lifetime
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2002
- 2002-03-06 MY MYPI20020788A patent/MY128608A/en unknown
- 2002-03-11 DK DK02713806.4T patent/DK1372590T3/da active
- 2002-03-11 MX MXPA03008274A patent/MXPA03008274A/es active IP Right Grant
- 2002-03-11 AR ARP020100868A patent/AR033028A1/es not_active Application Discontinuation
- 2002-03-11 ES ES02713806T patent/ES2333107T3/es not_active Expired - Lifetime
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- 2002-03-11 EP EP02713806A patent/EP1372590B1/en not_active Expired - Lifetime
- 2002-03-11 CN CN02809577.4A patent/CN1228038C/zh not_active Expired - Fee Related
- 2002-03-11 CA CA002440601A patent/CA2440601C/en not_active Expired - Fee Related
- 2002-03-11 BR BRPI0208037-0B1A patent/BR0208037B1/pt not_active IP Right Cessation
- 2002-03-11 TW TW091104443A patent/TWI256895B/zh not_active IP Right Cessation
- 2002-03-11 DE DE60234086T patent/DE60234086D1/de not_active Expired - Lifetime
- 2002-03-11 WO PCT/US2002/007105 patent/WO2002072050A1/en active IP Right Grant
- 2002-03-11 AT AT02713806T patent/ATE446078T1/de not_active IP Right Cessation
- 2002-03-11 PL PL364562A patent/PL208885B1/pl unknown
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102711661A (zh) * | 2010-01-29 | 2012-10-03 | 高露洁-棕榄公司 | 用于口腔治疗给药的牙条 |
| CN105963279A (zh) * | 2010-01-29 | 2016-09-28 | 高露洁-棕榄公司 | 用于口腔治疗给药的牙条 |
| CN103826595A (zh) * | 2011-09-14 | 2014-05-28 | 高露洁-棕榄公司 | 增白牙贴 |
| CN103826595B (zh) * | 2011-09-14 | 2016-11-09 | 高露洁-棕榄公司 | 增白牙贴 |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI256895B (en) | 2006-06-21 |
| CA2440601A1 (en) | 2002-09-19 |
| ATE446078T1 (de) | 2009-11-15 |
| CN1228038C (zh) | 2005-11-23 |
| HK1061800A1 (en) | 2004-10-08 |
| NZ528196A (en) | 2005-02-25 |
| MY128608A (en) | 2007-02-28 |
| DE60234086D1 (de) | 2009-12-03 |
| EP1372590A1 (en) | 2004-01-02 |
| BR0208037B1 (pt) | 2013-11-12 |
| BR0208037A (pt) | 2004-02-25 |
| PL208885B1 (pl) | 2011-06-30 |
| MXPA03008274A (es) | 2003-12-12 |
| CA2440601C (en) | 2009-12-29 |
| US6419906B1 (en) | 2002-07-16 |
| ES2333107T3 (es) | 2010-02-17 |
| PL364562A1 (en) | 2004-12-13 |
| EP1372590B1 (en) | 2009-10-21 |
| DK1372590T3 (da) | 2010-02-15 |
| AR033028A1 (es) | 2003-12-03 |
| WO2002072050A1 (en) | 2002-09-19 |
| ZA200307244B (en) | 2004-09-16 |
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