CN1551729A - 除污渍口香糖和糖果组合物及其制造和使用方法 - Google Patents
除污渍口香糖和糖果组合物及其制造和使用方法 Download PDFInfo
- Publication number
- CN1551729A CN1551729A CNA028173686A CN02817368A CN1551729A CN 1551729 A CN1551729 A CN 1551729A CN A028173686 A CNA028173686 A CN A028173686A CN 02817368 A CN02817368 A CN 02817368A CN 1551729 A CN1551729 A CN 1551729A
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- Prior art keywords
- spot
- chewing gum
- agent
- remove
- composition
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- Granted
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- 238000000034 method Methods 0.000 title claims abstract description 23
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Classifications
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- A—HUMAN NECESSITIES
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- A23G3/362—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing inorganic compounds
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- A—HUMAN NECESSITIES
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- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23G4/00—Chewing gum
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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Abstract
一种包含选自阴离子和非离子表面活性剂的除污渍剂的口香糖组合物或糖果组合物形式的组合物及其制备和使用方法，以去除包括牙齿在内的牙齿材料上的污渍。
Description
相关申请
本申请要求了2000年12月20日提交的美国专利申请No.09/741,523的优选权，该专利申请要求了2000年3月10日提交的美国临时专利申请No.60/188,554的优选权利益。
发明领域
本发明总体上涉及包含有效量的选自阴离子或非离子表面活性剂的除污渍组分的口香糖和糖果组合物，并涉及以一种有利于除污渍组分释放的方式制备该组合物的方法。
发明背景
牙齿增白或除污渍组分已知被添加到洁齿组合物如牙膏、漱口液等中。这类组合物包括如在美国专利No.5,256,402和No.5,824,291中公开的磷酸二钙、过氧化物和过碳酸盐等。
已知在衣物洗涤剂组合物中采用包括非离子表面活性剂在内的表面活性剂。例如，此类表面活性剂在国际公布No.WO92/06160和No.WO95/33034中公开。已知在衣物洗涤剂组合物中使用非离子表面活性剂以提高此类组合物去除脂类/油类污渍的效力。
美国专利No.5,645,821公开了一种用以清洁和增白牙齿的口腔卫生组合物，它包括水、胶凝剂、阴离子表面活性剂以及碱土金属氢氧化物和碳酸盐的混合物。WO88/00463公开了一种用于去除和/或防止牙斑并去除污渍的口腔用组合物，它包括油相容的表面活性剂和至少百分之一重量的苯甲酸盐。另外据称该组合物包含杀生物剂，如氯已啶(chlorhexidine)或其衍生物。示例的表面活性剂是十二烷基硫酸钠，而且据称该组合物包含增塑剂，包括聚乙二醇、甘油等。该文献声称该组合物能够以洁齿剂、糖锭或口香糖的形式使用。
其中公开了其它口香糖组合物和用于除污渍的活性成分的文献包括WO99/43294(亚氯酸根离子)；WO99/27798(包括碳酸氢钠和囊封的天冬甜素的水溶性产品)；中国专利文献No.1196235(过氧化氢)；美国专利No.5,824,291(碱金属碳酸盐过氧水合物)；WO98/29088(半胱氨酸蛋白酶)；WO98/18339(骨盐、三磷酸钙和/或羟基磷灰石)；以及美国专利No.5,629,035(碱金属碳酸氢盐)。
美国专利No.4,952,407公开了一种含甘油单月桂酸酯形式的牙斑去除剂的口香糖组合物。该组合物一般含有高的填料含量，其中该填料是无机材料，如碳酸钙、滑石、碳酸氢钠、磷酸二钙和它们的混合物。
对于涂覆的口香糖组合物来说，如在WO00/35296和WO00/35298中所公开的，已知在口香糖涂层或任选的芯中提供活性剂，如药剂。
与牙膏、漱口液和其它洁齿组合物不同，口香糖组合物在递送试剂的方面遇到了特殊问题。口香糖组合物通常包括非水溶性胶基，它构成口香糖组合物的主体，但却常常捕获与该胶基相容的试剂。而添加额外量的试剂也成问题，因为其会对口香糖组合物的完整性、感觉和/或味道性能产生不利影响。
因而，如果一种除污渍剂可被有效地加入口香糖组合物中并在咀嚼时以提供有效量除污渍剂的方式从其中释放，那么将会在提供用于包括牙齿在内的牙齿材料的清洁的除污渍剂领域中取得显著进展。该口香糖组合物因而不仅为用户提供咀嚼乐趣，而且还提供有益的洁齿作用。
糖果组合物在本领域中是众所周知的。举例来说，此类组合物包括硬质糖果、牛轧糖、包糖衣食品(panning goods)、凝胶糖果、夹心糖果、软糖等。与经常在口中停留几分钟甚至更长时间的口香糖组合物不同，糖果组合物由于它们经咀嚼较快地溶解而往往在口中的时间较短。尽管如此，向糖果组合物中提供有效量除污渍剂以使它们能够提供有益的洁齿效果是非常有益的。
发明概述
本发明一般涉及在其中已有效地加入除污渍材料以获得实现除污渍效果的足量除污渍材料的除污渍口香糖和糖果组合物。
在本发明的一个特定方面中，提供一种选自口香糖组合物和糖果组合物的除污渍组合物，它包括有效除污渍量的选自阴离子表面活性剂或非离子表面活性剂的至少一种除污渍剂，所述除污渍剂以能够从该组合物中释放有效量的除污渍剂的方式提供。
根据本发明的一个方面，提供一种除污渍口香糖组合物，该组合物包括芯和由至少一层构成的涂层，其中芯和涂层当中的至少一种包含除污渍有效量的选自阴离子或非离子表面活性剂或其混合物当中的至少一种除污渍剂。另外还公开了一种用本发明口香糖组合物去除污渍的方法。
在本发明的另一方面中，提供一种口香糖组合物，其中在制备它的过程中同时(at atime)添加除污渍剂，这促进了在咀嚼运动中除污渍剂的释放。
在本发明的又一方面中，提供一种除污渍糖果组合物，它包括有效除污渍量的选自阴离子或非离子表面活性剂或其混合物当中的至少一种除污渍剂。另外还公开了一种采用本发明糖果组合物去除污渍的方法。
在本发明的一种优选形式中，无论是口香糖还是糖果组合物的表面活性剂均选自中和长链脂肪酸酯类和盐类，最优选含14-20个碳原子，并且尤其是硬脂酸钠和棕榈酸钠及其混合物，以及柠檬酸单甘油酯和二甘油酯的混合物。
本发明的详细描述
申请人已经确定，通过适当选择除污渍剂和口香糖及糖果组合物配方以及把除污渍剂加入组合物中的方式可以制备有效除污渍的口香糖和糖果组合物，其中该加入方式可释放有效量的除污渍剂，使其与包括牙齿表面在内的牙齿材料的表面接触，同时保持了通常与这些产品相关的感官特性。
本发明的口香糖组合物可以涂覆或未涂覆，并且可以是块状、棒状、颗粒状或球状等的形式。不同形式的口香糖组合物的组成是类似的，但各组分的比例有所不同。例如，涂覆的口香糖组合物可含有低百分比的软化剂。颗粒状和球状则具有小的口香糖芯，其随后用糖溶液或无糖溶液涂覆，形成硬壳。块状和棒状通常所配制的质地比口香糖芯要软。但对于本发明的实施来说，为了克服活性表面活性剂对胶基的任何不利的软化作用，优选配制质地较硬(即比一般使用的更软)的块状或棒状口香糖。
夹心口香糖是另一种常见口香糖形式。其胶质部分具有与上述类似的组成和生产方式。但是，夹心一般是水溶液或凝胶，它在生产过程中被注入胶质的中心。除污渍剂可任选地在生产夹心时加入该夹心中，或者加入到胶质中。夹心口香糖也可任选地被涂布，并以各种形式制备，如棒糖的形式。
为了实施本发明，优选使用其中除污渍剂在芯和涂层至少之一中涂覆的口香糖。为了去除污渍，最优选的是其中除污渍剂至少在涂层中的涂覆的口香糖。
本发明口香糖组合物包括胶基和其它典型口香糖组合物中的大部分组分，如甜味剂、软化剂和风味剂等。本发明采用选自阴离子表面活性剂和非离子表面活性剂的至少一种除污渍剂。该口香糖组合物可包含减量的软化剂，如卵磷脂或甘油，或者可以省去软化剂。另外，该口香糖组合物含有比传统口香糖组合物更大量的糖醇，有利于把本发明所采用的除污渍剂递送到牙齿表面。
根据本发明口香糖组合物的一个方面，除污渍剂在生产口香糖组合物的过程中添加，也就是说，与甜味剂、风味剂等一起添加。在本发明的另一方面中，除污渍剂在最后步骤之一中添加，优选在配制口香糖组合物的最后一步添加。申请人已经确定，这种方法的改进将除污渍剂加入口香糖组合物中，而不会出现当除污渍剂与胶基混合时可能会发生的除污渍剂大量地结合于其中的情况。因此，当除污渍剂仅松散地包含在口香糖组合物中时，其在典型咀嚼运动中可以更有效地从口香糖组合物中释放。因此，除污渍剂的材料部分不含胶基。
在本发明的另一方面中，不溶性的胶基通常包括弹性体、弹性体增塑剂、蜡、脂肪、油、乳化剂、填料、组织改进剂，并可包括需要的下述除污渍剂。
弹性体构成胶基的约5-95wt％，优选10-70wt％且最优选15-45wt％。弹性体的例子包括合成弹性体，如聚异丁烯、聚丁烯、异丁烯-异戊二烯共聚物、苯乙烯-丁二烯共聚物、聚乙酸乙烯酯等。弹性体也可包括天然弹性体如天然橡胶以及天然树胶如节路顿胶、lechicaspi、perillo、massaranduba balata、糖胶树胶、gutta hang kang或其混合物。其它弹性体对于本领域普通技术人员来说是已知的。
弹性体增塑剂在其被用于胶基中时改善了成品口香糖的硬度。高弹体增塑剂通常的量约占胶基的0-75wt％，优选约5-45wt％，最优选约10-30wt％。高弹体增塑剂的例子包括天然松香酯，如部分氢化松香的甘油酯、浮油松香甘油酯、部分氢化的松香的季戊四醇酯、松香的甲酯和部分氢化的甲酯等。也可在胶基组合物中采用合成高弹体增塑剂，如萜烯树脂。
蜡包括合成和天然存在的蜡，如聚乙烯、蜂蜡、巴西棕榈蜡等。也可使用石油蜡，如石蜡。蜡在胶基中所占的量约为0-30wt％。蜡有助于成品口香糖的固化，并有助于促进风味的释放，同时可延长产品的保存期限。
填料改进胶基的质地并有利于加工。这类填料的例子包括硅酸镁和硅酸铝、粘土、矾土、滑石、二氧化钛、纤维素聚合物等。填料一般的量是1-60wt％。
胶基中使用的软化剂的例子包括氢化和部分氢化的植物油、可可油、甘油单硬脂酸酯、甘油三乙酸酯、二和三甘油酯、脂肪酸，如硬脂酸、棕榈酸、油酸、亚油酸、亚麻酸等。
胶基构成口香糖组合物的5-95wt％，更典型是10-50wt％，最优选占口香糖的25-35wt％。较大量的胶基是优选的。
口香糖组合物中使用的其它组分包括甜味剂，天然或人工合成以及含糖或无糖均可。甜味剂在口香糖中所占的量一般约为20-80wt％，优选约30-60wt％。无糖甜味剂包括但不限于糖醇，如山梨糖醇、甘露糖醇、木糖醇、氢化淀粉水解产物、麦芽糖醇等。也可含有高效力甜味剂，如三氯半乳庶糖、天冬甜素、双氧噁噻嗪等。高效力甜味剂的量一般约为0-1.0wt％。
用量范围宽的风味剂可在约0.1-10.0wt％之间选择，优选约为0.5-5.0wt％。香料用于口香糖组合物中是众所周知的，包括柑桔油、椒样薄菏油、留兰香油、冬青油、薄菏醇等。
使用软化剂可改进口香糖组合物的质地。与传统口香糖组合物不同，本发明组合物中的软化剂通常以少量存在，约占口香糖总重的0.5-10wt％。
可存在于本发明口香糖组合物中的其它物质包括抗氧化剂(如丁基化羟基茴香醚、丁基化羟基甲苯、β-胡萝卜素、生育酚、着色剂、风味剂等。
把涂层涂布于口香糖组合物上的涂布技术是众所周知的，如盘式(pan)涂布和喷涂。在实施本发明时优选的是使用适合形成硬糖果层的溶液进行涂布。无论是糖还是糖醇均可与高效力甜味剂、着色剂、风味剂和粘结剂一起用于此目的。当在口香糖组合物的涂层中提供除污渍剂时，该除污渍剂溶液优选地与风味剂交替使用。
甜味剂可占涂覆糖浆重量的大约30wt％-80wt％。粘结剂可占涂覆糖浆重量的约1wt％-15wt％。也可以存在少量任选的添加剂。适于在涂覆糖浆中使用的甜味剂包括无糖甜味剂，如多元醇类，如木糖醇、山梨糖醇、甘露糖醇及其混合物；以及麦芽糖醇、异麦芽糖醇、氢化淀粉水解产物和氢化葡萄糖浆。也可包括单糖、二糖和多糖。糖类如蔗糖、果糖、葡萄糖、galatose和麦芽糖也可被用作甜味剂。适用于该涂覆糖浆中的其它甜味剂包括但不限于游离糖精酸、糖精的水溶性盐、环己基氨基磺酸盐、palatinit二氢查耳酮、甘草甜、L-天冬氨酰-L-苯丙氨酸甲酯、氨基酸类甜味剂、沙马汀、甜菊苷、二氢查耳酮化合物、双氧噁噻嗪盐及其混合物。
在涂覆糖浆中可添加少量的其它成分，包括吸湿化合物、防粘化合物、分散剂和成膜剂。适用于涂覆糖浆中的吸湿化合物包括甘露糖醇或磷酸二钙。也可起到填料作用的有用的防粘化合物的例子包括滑石、三硅酸镁和碳酸钙。这些成分可占糖浆重量的约0.5wt％-5wt％。可用在涂覆糖浆中的分散剂的例子包括二氧化钛、滑石或上述的其它防粘化合物。
该涂覆糖浆通常被加热并且其一部分沉积在芯上。通常，涂覆糖浆的一次沉积并不足以提供所需量或厚度的涂层，通常需要用涂覆糖浆涂布第二、第三或更多层，以使涂层的重量和厚度达到所希望的程度，并使各层在每次涂布之间干燥。
口香糖组合物发明的一个优选方面把除污渍剂添加到涂层中。除污渍剂优选在糖浆涂覆之后添加。优选随后在用除污渍剂涂布之前施涂高效力甜味剂涂层。优选除污渍剂的施涂与风味剂溶液的施涂交替进行。在本发明的实施中，除污渍剂可以以溶液，也可以以干料涂布，如果适合的话，熔融并施涂。对于脂肪酸盐来说，可优选干料。在涂布口香糖组合物时，涂覆糖浆的涂布是连续的，直到口香糖单体的平均重量达到所需的涂层重量，优选达到涂层占成品球团重量的20-30wt％为止。
本发明也包括含有适当选择的除污渍剂的糖果组合物。这类糖果组合物包括压制片剂，如薄荷糖、硬质糖果、牛轧糖、凝胶、夹心糖果、软糖、包糖衣食品以及符合普遍接受的关于糖果组合物的定义的其它组合物。
如薄荷糖的压制片形式的糖果组合物一般可通过把精细筛选的糖或糖代用品、风味剂(如椒样薄荷风味剂)、如阿拉伯树胶的填充剂以及任选的着色剂混合在一起而制成。把风味剂、填充剂混合在一起并在随后逐渐加入糖或糖代用品，如果需要，一起添加着色剂。
随后使该产物通过具有所需筛目尺寸(如12目)的筛子来成粒，随即通常在55-60EC下干燥。所获得的粉末被送入装有大尺寸冲压机的压片机中，所形成的球团被破碎成颗粒，然后压制。
高度熬制的糖果通常含有糖或糖代用品、葡萄糖、水、风味剂和任选的着色剂。把糖溶解在水中，随后添加葡萄糖。使该混合物至沸腾。所获得的可能事先已添加了着色剂的液体被倒入涂油的块上并冷却。随后加入香料并捏合成冷却了的物料。所获得的混合物随后送入现有技术已知的糖果轧块机装置中，形成最终的硬糖果形状。
牛轧糖组合物通常包括两种主要成分：高度熬制的糖果和弗拉贝。例如，把蛋清或其代用品与水混合并搅拌形成轻微的泡沫。把糖和葡萄糖加入水中并且通常在大约130-140EC下煮沸，把所获得的熬煮产物倒入混合机中并搅打至乳状为止。
把搅打的蛋清和风味剂与乳状产物掺混，之后彻底混合该掺混物。
有关糖果组合物制备的其它细节可见Skuse的CompleteConfectioner(第13版)(1957)，包括pp.41-71，133-144和255-262；以及Sugar Confectionery Manufacture(第2版)(1995)，E.B.Jackson，Editor，PP.129-168，169-188，189-216，218-234和236-258，它们均被引入本文以供参考。
根据本发明，一种有效除污渍量的阴离子和/或非离子表面活性剂被用作口香糖和糖果组合物的除污渍剂。本发明可采用的除污渍剂的典型实例包括硫酸化油酸丁酯、中和长链脂肪酸酯和盐，尤其是硬脂酸和棕榈酸的钠盐和钾盐及其甲酯和乙酯、油酸钠、富马酸的盐、potassium glomate、有机酸单甘油酯和二甘油酯类，如硬脂基单甘油柠檬酸酯、琥珀硬脂精、磺基钠琥珀酸二辛酯、甘油三硬脂酸酯、卵磷脂、羟基化卵磷脂、十二烷基硫酸钠、乙酰化单甘油酯、琥珀酰化单甘油酯、柠檬酸单甘油酯、乙氧基化单和双甘油酯、单硬脂酸山梨糖醇酐酯、硬脂酰基-2-乳酸钙、硬脂酰基-乳酸钠、乳酸脂肪酸甘油和丙二醇(propylene glycerol)酯、C8-C24脂肪酸的甘油乳酸酯，优选C14-C20脂肪酸的甘油乳酸酯、C8-C24脂肪酸的聚甘油酯，优选C14-C20脂肪酸的聚甘油酯、藻酸丙二醇酯、蔗糖C8-C24脂肪酸酯，优选蔗糖C14-C20脂肪酸酯、二乙酰酒石酸或柠檬酸单和双甘油酯、三醋精和类似物及其混合物。
示例的优选除污渍剂选自硬脂酸钠或棕榈酸钠或其混合物、油酸钠、柠檬酸或乳酸单甘油酯和二甘油酯混合物、硬脂酸甘油酯和乳酸甘油酯及其混合物、蔗糖单硬脂酸酯、蔗糖二硬脂酸酯、蔗糖单月桂酸酯、蔗糖二月桂酸酯、单硬脂酸的聚甘油酯、单月桂酸的聚甘油酯及其混合物。
在本发明口香糖组合物中使用的优选表面活性剂是硬脂酸钠，通常作为与棕榈酸钠形成的50/50的混合物来提供，以及单甘油和/或二甘油酯的至少一种柠檬酸酯的混合物。后一种类型中市售的除污渍剂的适当例子是Condea Vista company销售的IMWITOR 370。另外优选的表面活性剂是乳酸单甘油酯和二甘油酯的混合物。
口香糖组合物中的除污渍剂的量所占口香糖组合物总重一般约为0.2-2.0wt％。除污渍剂的优选量是约0.4-1.2wt％。除污渍剂的量将根据所采用的除污渍剂的特定个体及其组合、口香糖组合物中其它成分的类型以及它们的相应的量而变化。例如，硬脂酸钠的优选量约为0.5wt％，乳酸单甘油酯和二甘油酯的混合物的优选量约为0.6wt％，而柠檬酸单甘油酯和二甘油酯的混合物(IMWITOR 370)的优选量约为0.6-1.0wt％。
在本发明糖果组合物中使用的优选除污渍剂是硬脂酸钠、棕榈酸钠及其混合物。正如针对口香糖组合物所指出的，硬脂酸钠一般通过与棕榈酸钠大致均分的混合物来提供。
可在本发明糖果组合物中使用的除污渍剂量的变化范围取决于糖果组合物的类型以及所采用的除污渍剂的特定个体或其组合。一般地，对于特定除污渍剂来说，在本发明糖果组合物中使用的除污渍剂的量将超过口香糖组合物所使用的除污渍剂量。
典型地，糖果组合物中的除污渍剂的量约占糖果组合物总重的0.2-20wt％。除污渍剂的优选量约为3-17wt％。
实施例
所提交的下述实施例仅仅是为了说明本发明，而非限制说明书和权利要求书所完全涵盖的本申请的范围。
实施例I： 口香糖产品的制备
A. 块状口香糖
表1
| 成分 | 样品1 | 样品2 |
| 胶基 | 29.75 | 29.75 |
| Atomite(填料) | 4.2500 | 4.2500 |
| 山梨糖醇 | 49.9868 | 49.4868 |
| 甘露糖醇 | 10.00 | 10.00 |
| 甘油 | 1.00 | 1.00 |
| 高效力甜味剂* | 1.3632 | 1.3632 |
| 风味剂 | 3.1500. | 3.1500 |
| 硬脂酸钠** | 0.500 | --- |
| IMWITOR370 | --- | 1.00 |
| 总量 | 100.00 | 100.00 |
*天冬甜素，Ace K混合物
**硬脂酸钠/棕榈酸钠@50/50
表1中所示的口香糖组合物的样品1和2用传统方法制备。把胶基加热至足以软化基料而不对基料的物理和化学构成产生不利影响。随后把熔化的胶基和填料加入混合锅中。混合加入糖醇、甘油、风味剂、高效力甜味剂和除污渍剂，以获得均匀混合物，其中除污渍剂最后加入。随后从混合锅中倒出该混合物并用传统技术将其辊压和修整至所需的单件尺寸。
表2所示口香糖组合物的样品3利用与样品1和2相同的方法制备，不同之处在于该混合物被辊压和修整至典型的棒状口香糖形式。样品4-6使用与样品3相同的方法制备。
表2
| 成分 | 样品3 | 样品4 | 样品5 | 样品6 |
| 胶基 | 36.600 | 36.600 | 36.600 | 36.600 |
| 山梨糖醇 | 38.773 | 38.773 | 38.773 | 38.773 |
| 甘露糖醇 | 11.000 | 11.000 | 11.000 | 11.000 |
| 木糖醇 | 2.500 | 2.500 | 2.500 | 2.500 |
| 氢化玉米糖浆 | 7.000 | 7.000 | 7.000 | 7.000 |
| 高效力甜味剂* | 0.264 | 0.264 | 0.264 | 0.264 |
| 风味剂 | 3.263 | 3.263 | 3.263 | 3.263 |
| 硬脂酸乳酸甘油酯 | 0.600 | ---------- | ---------- | ---------- |
| 糖酯** | ---------- | 0.600 | ---------- | ---------- |
| 聚甘油脂肪酸酯*** | ---------- | ---------- | 0.600 | ---------- |
| Imwitor370 | ---------- | ---------- | ---------- | 0.600 |
| 总量 | 100.000 | 100.000 | 100.000 | 100.000 |
*天冬甜素/Ace K混合物
**蔗糖硬脂酸酯或蔗糖月桂酸酯
***单硬脂酸酯或单月桂酸酯
表3所示口香糖组合物的样品7利用针对样品1和2所述的相同方式的传统方法制备。样品8和9利用与样品7相同的方法制备。
表3
| 成分 | 样品7 | 样品8 | 样品9 |
| 胶基 | 36.600 | 36.600 | 36.600 |
| 麦芽糖醇 | 25.273 | 25.273 | 25.273 |
| 木糖醇 | 29.000 | 29.000 | 29.000 |
| 氢化玉米糖浆 | 5.000 | 5.000 | 5.000 |
| 高效力甜味剂* | 0.264 | 0.264 | 0.264 |
| 风味剂 | 3.263 | 3.263 | 3.263 |
| 硬脂酸乳酸甘油酯 | 0.600 | ---------- | ---------- |
| 糖酯** | ---------- | 0.600 | ---------- |
| 聚甘油脂肪酸酯*** | ---------- | ---------- | 0.600 |
| 总量 | 100.000 | 100.000 | 100.000 |
高效力甜味剂*：天冬甜素/Ace K混合物
糖酯**：蔗糖硬脂酸酯或蔗糖月桂酸酯
聚甘油脂肪酸酯***：单硬脂酸酯或单月桂酸酯
B.涂覆的口香糖-涂层中含除污渍剂
表4
| 成分 | 样品10 | 样品11 | 样品12 |
| 口香糖芯 | |||
| 胶基 | 26.250 | 26.250 | 26.250 |
| Atomite(填料) | 3.750 | 3.750 | 3.750 |
| 山梨糖醇 | 33.525 | 33.525 | 33.5250 |
| 甘露糖醇 | 7.500 | 7.500 | 7.500 |
| 风味剂 | 2.8075 | 2.8075 | 2.8075 |
| 甘油 | 1.00 | 1.00 | 1.00 |
| 高效力甜味剂* | 0.7875 | 0.7875 | 0.7875 |
| 涂层 | |||
| 麦芽糖醇 | 22.1228 | 21.6228 | 22.1228 |
| Ace-K | 0.0350 | 0.0350 | 0.0350 |
| 风味剂 | 0.343 | 0.343 | 0.343 |
| 阿拉伯树胶 | 1.1678 | 1.1678 | 1.1678 |
| 二氧化钛 | 0.1780 | 0.1780 | 0.1780 |
| 小烛树蜡 | 0.0334 | 0.0334 | 0.0334 |
| 硬脂酸钠** | 0.500 | ---- | ---- |
| IMWITOR370 | ---- | 1.00 | ---- |
| 油酸钠 | ---- | ---- | 0.5000 |
| 总量 | 100.00 | 100.00 | 100.00 |
*天冬甜素/Ace K混合物
**硬脂酸钠/棕榈酸钠@50/50
口香糖芯利用与本文A部分中所述的相同方法制备。熔化的胶基和填料被加入混合锅中并开始混合。把混合的糖醇、甘油、风味剂、高效力甜味剂混合物分几份加入，获得均匀混合物。随后从混合锅中排出该混合物并用传统技术形成芯。
把芯置于涂布盘中，需要时破碎成单件。把含70wt％麦芽糖醇以及二氧化钛、阿拉伯树胶和水的无糖溶液加热到70℃-80℃之间。把该溶液分层喷涂到口香糖芯单件上，并在各次喷涂之间干燥，同时涂布盘连续旋转，确保获得口香糖芯的光滑均匀的涂层。
涂层累积成成品球团重的约8％。随后加入Ace-K并接着用上述涂覆溶液涂布另一层，接着使其干燥。
表2中示出的20％的除污渍剂溶液是通过把水加热到65℃-75℃之间并在随后缓慢加入除污渍剂来制备的。该溶液在低速搅拌下混合，避免形成泡沫，直至获得透明溶液为止。对于整个涂布过程来说，该溶液被保持在同一温度下。
在高效力甜味剂层被干燥之后，在交替的层中加入含除污渍剂和风味剂的溶液，直到所有各种材料被加入为止，其中要使每一层在施涂下一层之前得以干燥。涂布过程利用涂覆溶液连续进行，直到获得占成品球团重24wt％的涂层为止。
该涂层随后用传统未道溶液外涂至获得25wt％的壳重。该球团随后用小烛树蜡在抛光盘中以传统方法抛光。
表5所示的口香糖组合物的样品13利用针对样品10-12所示的相同方式的传统方法制备。样品14和15的制备方法与样品13的制备方法相同。
表5
| 成分 | 样品13 | 样品14 | 样品15 |
| 口香糖芯 | |||
| 胶基 | 31.100 | 31.100 | 31.100 |
| 山梨糖醇 | 27.074 | 27.074 | 27.074 |
| 甘露糖醇 | 7.700 | 7.700 | 7.700 |
| 木糖醇 | 2.500 | 2.500 | 2.500 |
| 氢化玉米糖浆 | 3.700 | 3.700 | 3.700 |
| 高效力甜味剂* | 0.272 | 0.272 | 0.272 |
| 香料 | 2.654 | 2.654 | 2.654 |
| 涂层 | |||
| 麦芽糖醇 | 21.974 | 21.974 | 21.974 |
| Ace-K | 0.035 | 0.035 | 0.035 |
| 风味剂 | 0.250 | 0.250 | 0.250 |
| 阿拉伯树胶 | 1.536 | 1.536 | 1.536 |
| 二氧化钛 | 0.178 | 0.178 | 0.178 |
| 小烛树蜡 | 0.054 | 0.054 | 0.054 |
| 硬脂酸乳酸甘油酯 | 1.000 | ---- | ---- |
| 糖酯** | ---- | 1.000 | ---- |
| 聚甘油脂肪酸酯*** | ---- | ---- | 1.000 |
| 总量 | 100.000 | 100.000 | 100.000 |
*天冬甜素/Ace K混合物
**蔗糖硬脂酸酯或蔗糖月桂酸酯
***单硬脂酸酯或单月桂酸酯
涂覆的口香糖-在芯中含有除污渍剂
表6
| 成分 | 样品16 |
| 口香糖芯 | |
| 胶基 | 26.250 |
| Atomite(填料) | 3.750 |
| 山梨糖醇 | 32.962 |
| 甘露糖醇 | 7.500 |
| 甘油 | 1.00 |
| 风味剂 | 2.8075 |
| 高效力甜味剂* | 0.7875 |
| 硬脂酸钠** | 0.563 |
| 涂层 | |
| 香料 | 0.343 |
| Ace-K | 0.0350 |
| 麦芽糖醇 | 22.6228 |
| 阿拉伯树胶 | 1.1678 |
| 二氧化钛 | 0.1780 |
| 小烛树蜡 | 0.0334 |
| 总量 | 100.00 |
*天冬甜素/Ace K混合物
**硬脂酸钠/棕榈酸钠@50/50
口香糖芯利用与部分A中所述相同的传统方法制备，其中除污渍剂最后加入。随后从混合锅中排出该混合物并用传统技术形成芯。
将芯置于涂布盘中并按本文部分B所示的方法涂布，不同的是省去该方法中施涂含除污渍剂的层的操作。
实施例2：口香糖产品的功效试验
A.机械咀嚼试验
按上述方法制备的口香糖的样品16在活体外机械咀嚼模型中进行试验。含碳酸氢钠的市售增白球团类口香糖被用作对照物。该口香糖样品用咀嚼机咀嚼，其中在咀嚼表面上有带污渍的牛齿，模拟人的上下齿。样品被咀嚼五分钟。在将牛齿样本置于咀嚼机之前和在一星期的模拟咀嚼之后(28个剂量)利用Chrom-A-Meter读数。随后通过计算DE值测定色变。然后将牛齿样品上的所有污渍除去，再次利用Chrom-A-Meter读数。随后计算污渍减少的百分比。其结果列于表7中。
表7-污渍减少
| 对照 | 样品16 | |
| ％污渍减少 | 11.9％ | 34.1％ |
试验表明：与市售牙齿增白口香糖相比，样品16在试验周期之后污渍减少。
B.临床试验
试验I：将六十个体分成4组，每组15个体。I组未进行处理。II组使用样品10的口香糖组合物，III组使用样品12的口香糖组合物，而IV组作为对照组使用上述含碳酸氢钠的市售球团型牙齿增白口香糖。
每一个体在饭后使用口香糖并在2周和4周的时间过后观察去除污渍的效果。结果在表8中示出。
表8-污渍评分 *
| 污渍评分 | 未处理 | 样品10 | 样品12 | 对照 |
| 基线 | 1.04 | 1.04 | 1.04 | 1.04 |
| 2周 | 1.09 | 0.93 | 1.02 | 1.06 |
| 4周 | 1.43 | 1.30 | 1.24 | 1.38 |
*Lobene污渍指数的McPhearson改进
如表8所示，与未处理组和上述含碳酸氢钠的市售球团型牙齿增白口香糖相比，样品10和12在4周的试验周期之后出现污渍的情况减少。
试验II：两百个体被分成4组，每组50个体。I组未进行处理。II组使用样品10的口香糖组合物，III组使用样品11的口香糖组合物，而IV组使用样品16的口香糖组合物。
每一个体在饭后使用口香糖并在4-8周的时间过后观察除污渍效果。结果在表9中示出。
表9-污渍减少
| 4周 | 未处理 | 样品10 | 样品11 | 样品16 |
| p-值()基线) | 0.904 | ＜0.001 | 0.002 | ＜0.001 |
| ％变化率 | 0.40 | 13.68 | 8.30 | 7.35 |
| 8周 | 未处理 | 样品10 | 样品11 | 样品16 |
| p-值()基线) | 0.056 | ＜0.001 | 0.002 | ＜0.001 |
| ％变化率 | -5.67 | 20.17 | 10.04 | 14.29 |
表10-成对比较
| 4周 | 样品10 | 样品11 | 样品16 |
| 无口香糖 | ＜0.001 | 0.010 | 0.018 |
| 样品10 | --- | 0.133 | 0.062 |
| 样品11 | --- | --- | 0.755 |
| 8周 | 样品10 | 样品11 | 样品16 |
| 无口香糖 | ＜0.001 | ＜0.001 | ＜0.001 |
| 样品10 | --- | 0.044 | 0.258 |
| 样品11 | --- | --- | 0.319 |
如表9和10所示，与未处理组相比，样品10、11和16的口香糖组合物呈现显著的除污渍效果。
实施例3：压制薄荷产品的制备
样品17
按下述方法制备2000批用于形成本发明的压制薄荷产品的组合物。
把98.0wt％的山梨糖醇、0.5wt％的二氧化硅、0.3wt％的风味剂和0.7wt％的天冬甜素在混合机中混合两分钟，直到获得均匀混合物为止。把0.1wt％的硬脂酸钠加入该混合物，然后共混四分钟。按传统方法将所形成的混合物制成单个的压制片剂。
样品18和19
重复样品17所用方法，不同的是硬脂酸钠的量分别增加到0.5％(样品18)和3.0％(样品19)，并相应地减少山梨糖醇的量。
样品20和对照物
重复样品17的方法，形成含有在表11中所示各种成分的压制片剂组合物。
表11
| 成分 | 样品20 | 对照物 |
| 山梨糖醇粉末天冬甜素双氧噁噻嗪钾风味剂硬脂酸钠 | 96.6220.1000.0500.2283.000 | 99.6220.1000.0500.228-.---- |
实施例4：压制薄荷产品的功效试验
对根据样品20和对照实施例生产的压制片剂进行测试，以测定它们从羟磷灰石圆盘上去除污渍的能力。
在以300rpm运转的搅拌棒的搅拌之下，把400ml去离子水加热并保持在37EC下。把两个有污渍的羟磷灰石圆盘悬在水中。把试验用薄荷产品浸入水中并使其溶解。一旦薄荷产品溶解就将圆盘从试验溶液中取出。针对不同薄荷产品重量/溶解时间重复此过程。在圆盘处理之前和之后利用Chrom-A-Meter读数，并计算差值。只使用去离子水重复这一过程并计算处理前后的差值。这些试样与对照样品和作为对照的水相比较，并计算污渍减少差值％。其结果在表12中示出。
表12
| 重量/溶解时间 | 水 | 对照 |
| 1.0g/3min | 84 | 52 |
| 1.5g/4min | 45 | 31 |
| 1.75g/4.5min | 101 | 26 |
| 2.0g/5min | 56 | 11 |
| 2.25g/5min | 81 | 22 |
表12所示结果给出了与只有水和没有除污渍剂的对照薄菏组合物进行对比的与样品20有关的污渍减少的百分比提高。
Claims (15)
1.除污渍口香糖组合物，包括芯和具有至少一层的任选涂层，所述芯和涂层当中的至少一种包含除污渍有效量的选自阴离子和非离子表面活性剂中的至少一种除污渍剂，所述除污渍剂以能够从该组合物中释放有效量的除污渍剂的方式存在。
2.权利要求1的除污渍口香糖组合物，其中除污渍剂选自硫酸化油酸丁酯、中和长链脂肪酸酯类及其盐类、油酸钠、富马酸的盐、potassium glomate、有机酸单甘油酯和二甘油酯类、琥珀硬脂精、磺基钠琥珀酸二辛酯、甘油三硬脂酸酯、卵磷脂、羟基化卵磷脂、十二烷基硫酸钠、乙酰化单甘油酯、琥珀酰化单甘油酯、柠檬酸单甘油酯、乙氧基化单和二甘油酯、单硬脂酸山梨糖醇酐酯、硬脂酰基-2-乳酸钙、硬脂酰基-乳酸钠、乳酸脂肪酸甘油和丙二醇酯、C8-C24脂肪酸的甘油-乳酸酯、C8-C24脂肪酸的聚甘油酯、藻酸丙二醇酯、蔗糖C8-C24脂肪酸酯、二乙酰酒石酸或柠檬酸或乳酸单和二甘油酯、三醋精及其混合物。
3.权利要求2的除污渍口香糖组合物，其中除污渍剂选自硬脂酸钠、棕榈酸钠及其混合物。
4.权利要求1的除污渍口香糖组合物，其中口香糖组合物是具有夹心和胶质部分的夹心口香糖组合物，所述除污渍剂存在于夹心，胶质部分或两者中。
5.权利要求1的除污渍口香糖组合物，其中除污渍剂的量占口香糖组合物总重的约0.2-2.0wt％。
6.权利要求5的除污渍口香糖组合物，其中除污渍剂是50/50的硬脂酸钠和棕榈酸钠的混合物，并且除污渍剂的量占口香糖组合物总重的约0.5wt％。
7.权利要求5的除污渍口香糖组合物，其中除污渍剂是有机酸单甘油酯和二甘油酯类，并且除污渍剂的量占口香糖组合物总重的约0.6-1.0wt％。
8.去除牙齿上的污渍的方法，包括咀嚼有效量的权利要求1的除污渍口香糖组合物。
9.生产权利要求1的除污渍口香糖组合物的方法，包括：在形成口香糖组合物的最后步骤之一中添加除污渍剂，使该除污渍剂可松散地包含在口香糖组合物之中，从而通过咀嚼可以有效地释放除污渍剂。
10.除污渍糖果组合物，包括除污渍有效量的选自阴离子或非离子表面活性剂中的至少一种除污渍剂，所述除污渍剂以能够从该组合物中释放有效量的除污渍剂的方式存在。
11.权利要求10的除污渍糖果组合物，其中除污渍剂选自硫酸化油酸丁酯、中和长链脂肪酸酯类及其盐类、油酸钠、富马酸的盐、potassium glomate、有机酸单甘油酯和二甘油酯类、琥珀硬脂精、磺基钠琥珀酸二辛酯、甘油三硬脂酸酯、卵磷脂、羟基化卵磷脂、十二烷基硫酸钠、乙酰化单甘油酯、琥珀酰化单甘油酯、柠檬酸单甘油酯、乙氧基化单和二甘油酯、单硬脂酸山梨糖醇酐酯、硬脂酰基-2-乳酸钙、硬脂酰基-乳酸钠、乳酸化脂肪酸甘油和丙二醇酯、C8-C24脂肪酸的甘油-乳酸酯、C8-C24脂肪酸的聚甘油酯、藻酸丙二醇酯、蔗糖C8-C24脂肪酸酯、二乙酰酒石酸或柠檬酸或乳酸单和二甘油酯、三醋精及其混合物。
12.权利要求11的除污渍糖果组合物，其中除污渍剂选自硬脂酸钠、棕榈酸钠及其混合物。
13.权利要求10的除污渍糖果组合物，其中除污渍剂的量占糖果组合物总重的约0.2-20wt％。
14.权利要求10的除污渍糖果组合物，其中糖果组合物选自硬质糖果、牛轧糖、凝胶糖果、夹心糖果、包糖衣食品和软糖。
15.去除牙齿上的污渍的方法，包括把有效量的权利要求10的除污渍组合物置于口腔中，直到该组合物溶解为止。
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-
2001
- 2001-09-06 US US09/947,876 patent/US6485739B2/en not_active Expired - Lifetime
-
2002
- 2002-08-02 DE DE2002751521 patent/DE02751521T1/de active Pending
- 2002-08-02 WO PCT/IB2002/003085 patent/WO2003020047A1/en active IP Right Grant
- 2002-08-02 CA CA2459487A patent/CA2459487C/en not_active Expired - Fee Related
- 2002-08-02 MX MXPA04002193A patent/MXPA04002193A/es active IP Right Grant
- 2002-08-02 KR KR10-2004-7003307A patent/KR20040044545A/ko not_active Application Discontinuation
- 2002-08-02 ES ES02751521T patent/ES2224905T1/es active Pending
- 2002-08-02 TR TR2004/02190T patent/TR200402190T3/xx unknown
- 2002-08-02 PL PL02367344A patent/PL367344A1/xx not_active Application Discontinuation
- 2002-08-02 NZ NZ531449A patent/NZ531449A/en unknown
- 2002-08-02 JP JP2003524369A patent/JP4928062B2/ja not_active Expired - Fee Related
- 2002-08-02 BR BR0212633-8A patent/BR0212633A/pt not_active IP Right Cessation
- 2002-08-02 EP EP02751521A patent/EP1423017A1/en not_active Withdrawn
- 2002-08-02 CN CNB028173686A patent/CN1237889C/zh not_active Expired - Fee Related
- 2002-09-04 AR ARP020103338A patent/AR036427A1/es not_active Application Discontinuation
- 2002-09-04 PE PE2002000845A patent/PE20030318A1/es not_active Application Discontinuation
- 2002-09-27 US US10/256,912 patent/US6696044B2/en not_active Expired - Fee Related
-
2004
- 2004-03-04 NO NO20040956A patent/NO20040956L/no not_active Application Discontinuation
-
2008
- 2008-08-13 AU AU2008205415A patent/AU2008205415A1/en not_active Abandoned
-
2009
- 2009-03-16 JP JP2009063068A patent/JP4732529B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-07 AU AU2010227014A patent/AU2010227014B2/en not_active Ceased
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2011
- 2011-12-14 JP JP2011273909A patent/JP2012080898A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1423017A1 (en) | 2004-06-02 |
| CN1237889C (zh) | 2006-01-25 |
| US20030124064A1 (en) | 2003-07-03 |
| JP2012080898A (ja) | 2012-04-26 |
| CA2459487A1 (en) | 2003-03-13 |
| MXPA04002193A (es) | 2004-06-11 |
| JP2009171977A (ja) | 2009-08-06 |
| US6485739B2 (en) | 2002-11-26 |
| US6696044B2 (en) | 2004-02-24 |
| PL367344A1 (en) | 2005-02-21 |
| AU2008205415A1 (en) | 2008-09-04 |
| NO20040956L (no) | 2004-03-04 |
| PE20030318A1 (es) | 2003-04-03 |
| AU2010227014B2 (en) | 2012-01-19 |
| AR036427A1 (es) | 2004-09-08 |
| JP4928062B2 (ja) | 2012-05-09 |
| NZ531449A (en) | 2004-08-27 |
| TR200402190T3 (tr) | 2004-11-22 |
| BR0212633A (pt) | 2004-08-24 |
| DE02751521T1 (de) | 2005-01-13 |
| JP4732529B2 (ja) | 2011-07-27 |
| WO2003020047A1 (en) | 2003-03-13 |
| KR20040044545A (ko) | 2004-05-28 |
| ES2224905T1 (es) | 2005-03-16 |
| US20020159955A1 (en) | 2002-10-31 |
| JP2005520491A (ja) | 2005-07-14 |
| CA2459487C (en) | 2010-11-16 |
| AU2010227014A1 (en) | 2010-11-04 |
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