CN1617928A - 聚阳离子水溶性共聚物和将聚阴离子大分子跨生物屏障传递的方法 - Google Patents
聚阳离子水溶性共聚物和将聚阴离子大分子跨生物屏障传递的方法 Download PDFInfo
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- CN1617928A CN1617928A CNA02827640XA CN02827640A CN1617928A CN 1617928 A CN1617928 A CN 1617928A CN A02827640X A CNA02827640X A CN A02827640XA CN 02827640 A CN02827640 A CN 02827640A CN 1617928 A CN1617928 A CN 1617928A
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- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
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Abstract
Description
共聚物 | N(UFCG) | W(PEI) | Mw | DNA/寡聚物结合 | 转染psDNA | 转染寡聚物 |
PEG-15PA-PEI400 | 0.0 | 2,344(10%) | 23,444 | + | - | - |
PEG-15PA-PEI800 | 0.0 | 8,400(30%) | 28,400 | + | + | + |
PEG-8PA-PEI800 | 0.0 | 2,607(11.5%) | 22,607 | + | - | + |
PEG-10PA-PEI1200 | 0.0 | 4,963(20.0%) | 24,936 | + | + | + |
PEG-8PA-PEI2K | 0.0 | 7,490(27%) | 27,490 | + | + | + |
PEG-15PA-GFLG-PEI400 | 9.0 | 2,000(7.8%) | 25,400 | - | - | - |
PEG-15PA-GFLG-PEI800 | 9.0 | 4,400(15.8%) | 27,900 | + | + | + |
PEG-8PA-GFLG-PEI400 | 3.8 | 1,087(4.8%) | 22,577 | + | - | + |
PEG-8PA-GFLG-PEI800 | 3.8 | 2.207(9.3%) | 23,697 | + | + | + |
PEG-8PA-GFLG-PEI2K | 3.8 | 4,975(18,8%) | 26.465 | + | + | + |
对照: | ||||||
PEI-25K(购自Sigma) | 25,000 | + | + | + | ||
PEI-2K(购自Polysciences) | 1,800 | + | - | + | ||
PEI-400(购自Sigma) | 400 | - | - | - |
Claims (64)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/996,507 | 2001-11-28 | ||
US09/996,507 US7060498B1 (en) | 2001-11-28 | 2001-11-28 | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1617928A true CN1617928A (zh) | 2005-05-18 |
CN1330765C CN1330765C (zh) | 2007-08-08 |
Family
ID=25542997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB02827640XA Expired - Fee Related CN1330765C (zh) | 2001-11-28 | 2002-06-26 | 聚阳离子水溶性共聚物和将聚阴离子大分子跨生物屏障传递的方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7060498B1 (zh) |
EP (1) | EP1461436A4 (zh) |
JP (1) | JP2005510572A (zh) |
CN (1) | CN1330765C (zh) |
AU (1) | AU2002345981B2 (zh) |
CA (1) | CA2468548A1 (zh) |
HK (1) | HK1078103A1 (zh) |
MX (1) | MXPA04005194A (zh) |
WO (1) | WO2003046185A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102154349A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化的桑叶多糖纳米粒基因载体及其制法 |
CN102154350A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化枸杞多糖纳米粒基因传递系统及其制法 |
CN112135838A (zh) * | 2018-03-29 | 2020-12-25 | 日油株式会社 | 分解性聚乙二醇键合物 |
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---|---|---|---|---|
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US9180081B2 (en) * | 2005-03-03 | 2015-11-10 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
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US20100093639A1 (en) * | 2006-12-29 | 2010-04-15 | Revance Therapeutics, Inc. | Transport Molecules Using Reverse Sequence HIV-TAT Polypeptides |
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JP2012521762A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いた神経成長因子β鎖(NGFβ)遺伝子発現のRNA干渉媒介性阻害 |
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EP2411516A1 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
JP2012521765A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いた細胞内接着分子1(ICAM−1)遺伝子発現のRNA干渉媒介性阻害 |
JP2012521764A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いた胸腺間質性リンパ球新生因子(TSLP)遺伝子発現のRNA干渉媒介性阻害 |
TWI465238B (zh) | 2009-12-09 | 2014-12-21 | Nitto Denko Corp | Hsp47表現之調節 |
CN108404123A (zh) | 2010-01-15 | 2018-08-17 | 康奈尔大学 | 降低细胞内蛋白质水平的方法 |
WO2011094759A2 (en) | 2010-02-01 | 2011-08-04 | The Regents Of The University Of California | Novel diagnostic and therapeutic targets associated with or regulated by n-cadherin expression and/or epithelial to mesenchymal transition (emt) in prostate cancer and other malignancies |
CA2801928C (en) | 2010-06-24 | 2018-04-10 | Quark Pharmaceuticals, Inc. | Double stranded rna compounds to rhoa and use thereof |
CA2805265A1 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
WO2012024170A2 (en) | 2010-08-17 | 2012-02-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP3372684B1 (en) | 2010-08-24 | 2020-10-07 | Sirna Therapeutics, Inc. | Single-stranded rnai agents containing an internal, non-nucleic acid spacer |
EP2609106A4 (en) | 2010-08-26 | 2014-03-19 | Merck Sharp & Dohme | RNA INTERFERENCE-MEDIATED INHIBITION OF EXPRESSION OF PHD2 GENE (PROLYL HYDROXYLASE DOMAIN 2) USING SMALL INTERFERING NUCLEIC ACID (PANI) |
WO2012047631A2 (en) | 2010-09-27 | 2012-04-12 | The Children's Hospital Of Philadelphia | Compositions and methods useful for the treatment and diagnosis of inflammatory bowel disease |
WO2012044979A2 (en) | 2010-10-01 | 2012-04-05 | The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Manipulation of stem cell function by p53 isoforms |
US20140134231A1 (en) | 2010-10-11 | 2014-05-15 | Sanford-Burnham Medical Research Institute | Mir-211 expression and related pathways in human melanoma |
WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
JP2014510721A (ja) | 2011-02-15 | 2014-05-01 | イミューン デザイン コーポレイション | ベクターワクチンによる免疫原特異的免疫応答を強化するための方法 |
EP2681314B1 (en) | 2011-03-03 | 2017-11-01 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating lung disease and injury |
NZ616304A (en) | 2011-04-08 | 2016-01-29 | Immune Design Corp | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
EP2557089A2 (en) | 2011-07-15 | 2013-02-13 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Compositions and methods for immunomodulation |
CN103827178B (zh) | 2011-07-26 | 2016-10-05 | 剑桥实业有限公司 | 超分子胶囊 |
BR112014011417B1 (pt) | 2011-11-11 | 2021-10-13 | Fred Hutchinson Cancer Research Center | Polipeptídeo isolado capaz de elicitar uma resposta de célula t antígeno-específica para ciclina a1 humana, composição imunogênica compreendendo o referido polipeptídeo, bem como método para preparar células apresentadoras de antígeno, antígeno-pulsadas,e uso destas para superexpressão de ccna1 |
CA2858630A1 (en) | 2012-01-12 | 2013-07-18 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
EP2617434A1 (en) | 2012-01-20 | 2013-07-24 | Laboratorios Del. Dr. Esteve, S.A. | HIV-1 integrase deficient immunogens and methods for loading dendritic cells with said immunogens |
GB201301648D0 (en) | 2013-01-30 | 2013-03-13 | Cambridge Entpr Ltd | Nested supramolecular capsules |
US11491227B2 (en) | 2012-02-20 | 2022-11-08 | Cambridge Enterprise Limited | Cucurbituril-based hydrogels |
BR112015004747A2 (pt) | 2012-09-12 | 2017-11-21 | Quark Pharmaceuticals Inc | moléculas oligonucleotídicas de fita dupla para p53 e métodos de uso das mesmas |
DK2895608T3 (en) | 2012-09-12 | 2019-01-21 | Quark Pharmaceuticals Inc | DOUBLE-STRENGTHED OIGONUCLEOTIDE MOLECULES FOR P53 AND PROCEDURES FOR USING IT |
MX370929B (es) | 2012-10-28 | 2020-01-08 | Revance Therapeutics Inc | Composiciones y usos de las mismas para el tratamiento seguro de la rinitis. |
UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
WO2015020960A1 (en) | 2013-08-09 | 2015-02-12 | Novartis Ag | Novel lncrna polynucleotides |
EP3542816A1 (en) | 2014-02-14 | 2019-09-25 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
CN106459076B (zh) | 2014-05-13 | 2019-01-04 | 诺华股份有限公司 | 用于诱导软骨发生的化合物和组合物 |
JP6753843B2 (ja) | 2014-05-14 | 2020-09-16 | タルグルムーネ セラピウティクス エージー | 改善されたポリエチレンイミンポリエチレングリコールベクター |
MX2017000630A (es) | 2014-07-15 | 2017-04-27 | Immune Design Corp | Regimenes de sensibilización-refuerzo con un adyuvante de agonista tlr4 y un vector lentiviral. |
US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
US10232050B1 (en) | 2014-12-12 | 2019-03-19 | Clemson University | Multi-functional particles and methods of using the same |
US11633355B2 (en) | 2014-12-12 | 2023-04-25 | Clemson University Research Foundation | Multi-functional particles and methods of using the same |
CA2984512A1 (en) | 2015-05-06 | 2016-11-10 | Benitec Biopharma Limited | Reagents for treatment of hepatitis b virus (hbv) infection and use thereof |
WO2016196366A1 (en) | 2015-05-29 | 2016-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Extension of replicative lifespan in diseases of premature aging using p53 isoforms |
KR102353847B1 (ko) | 2016-04-14 | 2022-01-21 | 베니텍 바이오파마 리미티드 | 안구인두 근이영양증(opmd)의 치료용 시약 및 이의 용도 |
EP3269734A1 (en) | 2016-07-15 | 2018-01-17 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Methods and compositions for the treatment of cancer |
CN107432935A (zh) * | 2017-09-12 | 2017-12-05 | 四川大学 | 一种阳离子聚合物/TDNs载药复合物及其制备方法 |
CA3133155A1 (en) | 2019-03-19 | 2020-09-24 | Fundacio Privada Institut D'investigacio Oncologica De Vall Hebron | Combination therapy for the treatment for cancer |
EP3808763A1 (en) | 2019-10-17 | 2021-04-21 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Compounds for immunomodulation |
US20230277600A1 (en) | 2021-10-20 | 2023-09-07 | University Of Rochester | Treatment Of Age-Related White Matter Loss By Competitive Replacement Of Glial Cells |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256652A (en) | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
SI8810082A8 (en) | 1988-01-18 | 1995-12-31 | Lek Tovarna Farmacevtskih | Process for preparing new inclusion complex of nicardipine or its hydrochloride with beta-cyclodextrine |
IT1241417B (it) | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
US5380536A (en) | 1990-10-15 | 1995-01-10 | The Board Of Regents, The University Of Texas System | Biocompatible microcapsules |
US5681747A (en) * | 1992-03-16 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof |
EP1236473A3 (en) | 1992-04-03 | 2003-01-15 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system |
US6113946A (en) | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
US5298410A (en) | 1993-02-25 | 1994-03-29 | Sterling Winthrop Inc. | Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life |
US5777078A (en) * | 1993-04-28 | 1998-07-07 | Worcester Foundation For Experimental Biology | Triggered pore-forming agents |
ZA951877B (en) | 1994-03-07 | 1996-09-09 | Dow Chemical Co | Bioactive and/or targeted dendrimer conjugates |
US5567410A (en) | 1994-06-24 | 1996-10-22 | The General Hospital Corporation | Composotions and methods for radiographic imaging |
US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
US5656611A (en) | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
FR2739292B1 (fr) | 1995-09-28 | 1997-10-31 | Rhone Poulenc Rorer Sa | Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations |
GB9623051D0 (en) | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
DE19726186A1 (de) * | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
US6333051B1 (en) | 1998-09-03 | 2001-12-25 | Supratek Pharma, Inc. | Nanogel networks and biological agent compositions thereof |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102154349A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化的桑叶多糖纳米粒基因载体及其制法 |
CN102154350A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化枸杞多糖纳米粒基因传递系统及其制法 |
CN102154349B (zh) * | 2010-12-30 | 2014-08-06 | 江苏大学 | 阳离子化的桑叶多糖纳米粒基因载体及其制法 |
CN112135838A (zh) * | 2018-03-29 | 2020-12-25 | 日油株式会社 | 分解性聚乙二醇键合物 |
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MXPA04005194A (es) | 2005-06-20 |
CN1330765C (zh) | 2007-08-08 |
JP2005510572A (ja) | 2005-04-21 |
HK1078103A1 (en) | 2006-03-03 |
EP1461436A1 (en) | 2004-09-29 |
CA2468548A1 (en) | 2003-06-05 |
US7060498B1 (en) | 2006-06-13 |
WO2003046185A1 (en) | 2003-06-05 |
EP1461436A4 (en) | 2006-03-22 |
AU2002345981A1 (en) | 2003-06-10 |
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