CN1902475A - 荧光计 - Google Patents

荧光计 Download PDF

Info

Publication number
CN1902475A
CN1902475A CNA200480038756XA CN200480038756A CN1902475A CN 1902475 A CN1902475 A CN 1902475A CN A200480038756X A CNA200480038756X A CN A200480038756XA CN 200480038756 A CN200480038756 A CN 200480038756A CN 1902475 A CN1902475 A CN 1902475A
Authority
CN
China
Prior art keywords
light
equipment
reverberator
fluorescence
detecting device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA200480038756XA
Other languages
English (en)
Other versions
CN1902475B (zh
Inventor
索伦·阿斯马尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precisense AS
Original Assignee
Precisense AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Precisense AS filed Critical Precisense AS
Publication of CN1902475A publication Critical patent/CN1902475A/zh
Application granted granted Critical
Publication of CN1902475B publication Critical patent/CN1902475B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G01J1/0407—Optical elements not provided otherwise, e.g. manifolds, windows, holograms, gratings
    • G01J1/0422—Optical elements not provided otherwise, e.g. manifolds, windows, holograms, gratings using light concentrators, collectors or condensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0636—Reflectors

Abstract

在用于在样品表面处产生和检测荧光的设备中，该设备高于该样品表面的高度减小，并且由于反射损耗和光散射而导致的所发射的荧光的损耗被最小化。该设备包括三维弯曲的光反射表面(40)，其横向于来自光源(32)的光的原始路径而引导该光，并且将该光聚焦到该样品表面处或该样品表面下的照明区(30)。该反射表面(40)还横向于所发射的荧光的原始路径并朝向检测器(46)收集、引导并至少部分地准直该荧光。

Description

荧光计
技术领域
本发明涉及荧光计，其是用于产生荧光并使用强度或时间分辨测量来测量荧光的设备。
背景技术
落射荧光显微镜(epifluorescence microscope)传统上具有线性光学装置，其中样品位置、分束器和检测器例如垂直地沿第一方向上的公共轴间隔地设置，且激发光源离置在一侧。此装置规定最小的高度约束，以提供空间使得从样品位置发射的荧光由透镜系统准直、通过分束器、滤波以移除不同于该荧光波长的波长，并最终聚焦到检测器上。这样的传统装置在图1中示出，如下面更详细地讨论的。在荧光应用中，所发射的荧光的强度通常是弱的。另外，如果荧光体位于光散射介质如皮肤，则荧光各向同性地或根据Lambert辐射图案来发射。在这两种情形中，所检测的荧光随光学系统的数值孔径而增大。在通常的落射荧光建立中，大数值孔径通常通过使用许多透镜而获得，该使用即使对涂覆的透镜也引入反射损耗和光散射。
值得期望的是，开发一种具有减小的复杂性的可替换通用光学装置，其可用于减小从样品位置测量的设备的必要高度。
发明内容
因此，本发明现在在第一方面中提供用于在一表面处或下产生和检测荧光的设备，所述设备包括：
光源，用于沿在所述表面上延伸的光路引导荧光激发光；
反射器，具有三维弯曲的、类似壳形的光反射界面，其被定位以接收从光源沿所述光路的一部分在所述表面上通过的光，并且相对于光路的所述部分横向地反射所述光，以便将所述光聚焦在所述表面处或下的照明区上用于在所述区激励荧光，并且用于收集在所述区发射的荧光，并且反射并至少部分地准直所述光以沿光路的所述部分返回；以及
检测器，用于接收在所述界面反射之后的以荧光发射的所述光。
上面所说的‘表面’可以是由两种不同材料之间的界面限定的物理表面，或者可以是相对于该设备可限定的虚拟表面。
该设备可以进一步包括分束器，其反射由所述光源发射的光以将其传到所述反射器，并且从所述反射器接收荧光，并且将所述荧光传到所述检测器。
所述反射器、光源和检测器优选地以一般是共面的方式设置，并且所述分束器优选地具有处于与反射器、光源和检测器的共面正交的平面上的平的反射表面。
该设备可以进一步包括激发滤光器，其从由光源发射的光选择激发波长以传到所述反射器。
该设备可以进一步包括发射滤光器，选择所发射的荧光波长以传到所述检测器。
该设备可以包括一透镜，其将荧光聚焦在所述检测器上。可替换地，可以使用又一个聚焦反射界面。
该或每个所述反射器界面可以基本上具有部分抛物面、非球形、环形或双锥形表面的形式。这样的反射器界面可以是抛物面、非球形、环形或双锥形表面。球形表面和非球形表面如双曲面、抛物面、椭球和扁椭球反射器界面可以由一等式限定：
z = cr 2 1 + 1 - ( 1 + k ) c 2 r 2
其中：
c从0.07到0.5并且k从-1.5到-0.7，其中z是沿旋转轴的z坐标的“垂度(sag)”，c是曲率(半径R的倒数)，k是圆锥常数且r是径向坐标。其它表面可以通过包括增加的Taylor展开的类似等式来描述。类似地，也可以得到用于环形和双锥形表面的等式，该环形例如有小面的环形，或分段的线性环形。
引导光到照明区的反射器的反射器界面可以包括抛物面、非球形、环形或双锥形表面的部分，其通过由竖立在该照明区中央的直圆柱体切割抛物面、非球形、环形或双锥形表面而产生。
所述反射器界面可以优选地基本上具有半抛物面的一部分的形式。
该设备还可以进一步包括容纳光源、反射器和检测器并且具有基座表面的机壳，该基座表面包含一窗口，用于将激发光传出机壳并且将荧光接收到机壳中，并且用于在使用中与在其处或其下发生所述荧光的所述表面接合。
优选地，所述光路与由所述基座表面限定的平面成不大于10度的角。
附图说明
将参考附图进一步描述和说明本发明，在附图中：
图1是传统落射荧光测量设备的示意性的侧面正视图；
图2是根据本发明的设备的第一实施例的透视图；
图3是示出当从其上置有镜的表面发射光时，其中收集了大多数能量的抛物面镜的区的图示；
图4是根据本发明的第二实施例的俯视图；
图5是图4的设备的透视图；
图6是图4中标记的线VI-VI′上的横截面；
图7示出图4的设备的修改；
图8示出根据本发明的第三实施例的俯视图；
图9是抛物面镜的形状随着圆锥常数变化的曲线图；以及
图10是示出检测的光功率与照明功率的比随着改变圆锥常数而变化的曲线图。
具体实施方式
用于落射荧光测量的一通常的建立在图1中示出。其设计用于在样品位置10产生和检测荧光，样品位置10可能例如是在例如显微镜载片上的体或物品的表面处或下。典型地，这样的表面将是水平的，并且为了方便，这在该设备的后面描述中被假定。激发光源12如LED定位为离置到样品位置10的一侧并且处于高于样品位置的高度h处。LED发射激发光16，其通过激发滤光器14以选择所需的激发波长。激发光落在成角度的分束器18、如侧面平行的二向色分束器18上。激发光的一部分以直角向下向样品位置反射，并通过聚焦透镜系统20，该透镜系统包括一个或多个简单或复合透镜。
从样品位置发出的荧光和反射的激发光由透镜系统20捕获，并且被准直成平行束，该平行束通过分束器18到理想地移除荧光波长之外所有波长的发射滤光器22，并且从那里到将荧光聚焦到检测器26上的第二透镜系统24。类似透镜系统20，透镜系统24可以包括一个或多个简单或复合透镜。
整个装置具有高于样品的总高度h′，其大约是3×h。
已经提出通过基于荧光的技术监视人或动物体中的化学物质的浓度。这些将涉及将激发光引导到皮肤上并且检测来自皮肤的荧光发射。相关的教示包括WO00/02048和WO02/30275。
我们注意到在这样的环境和其它环境中减小所使用的荧光检测设备的尺度h′是所需要的。
图2示出了根据本发明的设备的一实施例。这里，该设备被描绘为放置在皮肤的表面上或要在其上检测荧光的类似表面上。为了后面描述的方便，皮肤的平面将被视为水平。光源32沿平行于皮肤表面的路径发射光，并且确定近似地等于该装置的总高度h′的用于该设备的高度h。
光通过激发滤光器34到设置在竖直平面上的二向色分束器38，并且被转向朝向取代了传统设备的透镜系统20的半抛物面形镜反射器40。该反射器将光向下聚焦到皮肤表面上的照明区30上或朝向恰好在皮肤表面下的一照明区。该反射器收集并准直来自照明区的荧光发射，并且将发射的光引导回分束器，发射的光通过分束器到达发射滤光器42。从那里，该光由与透镜系统24相同类型的透镜系统44聚焦并且在检测器46被检测。
可以看到，该设备的竖直高度已经从图1中的近似3×h减小到图2中的仅h。
通常，干涉滤光器在荧光计中用作激发和发射滤光器。这些要求：如果要得到预期的波长通过特性，则入射光应该与滤光器的平面正交，因为使用倾斜的入射光，滤光器通带将移向较短的波长。因此要求对入射到这些滤光器上光束进行准直。
可以以许多方式构造抛物面反射器40以产生所需形状的反射界面。例如，该界面可以是在抛物面内部的空气与一体的反射凹内部表面之间。可替换地，该界面可以形成在立体半抛物面元件的凸外部表面处，例如玻璃或塑料的半抛物面块的镀银的外部。
整个所示出的设备将受机壳或壳体(如图6中所示)的限制，该机壳或壳体具有底表面，该底表面包含孔，该孔可被填充以一透明窗口(适当地是玻璃、石英(silica)或者在一些应用中是塑料)，用于保护光学元件不受灰尘和湿气影响，并且用于允许将激发光和荧光传到和传自照明区中的样品。所述设备因此可以是壳体中的简单开口或者光学窗口。
来自检测器的信号可以被馈送到适当的电子线路，用于以已知方式分析。LED可以如已知的由适当的电子线路来供给功率，并且LED供给线路和检测信号处理线路一般将形成一集成线路的一部分，该集成线路用于例如在基于FRET(荧光谐振能量转移)的化验中产生荧光的基于强度的或时间分辨(频域)的测量。
所示出的设备提供了用于捕获来自照明区的荧光的高的数值孔径，同时实现紧凑的光学几何，适合用于空间极其宝贵的地方，例如在将穿在体上的装置中。
不需要所有示出的抛物面表面以获得良好的结果。抛物面不需要如所示地设置为其轴与其上待使用该装置的表面一致，而是可以向上成角度以得到用于检测器光学元件的表面上的某个附加高度。荧光束可不被反射器完全准直，但是可由辅助的透镜系统部分地准直。该设备的物理照明区不需要位于反射器的焦点处。反射器界面不需要是真正抛物面的形式。这些概念在后续的图中进一步示出。
如图3中所示，将接收从照明区发射的荧光的大部分并且将其准直输出到检测器的抛物面表面M的区域，将是由位于照明区中央上的直圆柱体C与抛物面表面自身的相交所限定的区域。抛物面表面的剩余部分因此不需要存在。清楚地，圆柱体越小，捕获的光就越少，所以优选地至少存在与由与半径r的圆柱体的相交所限定的一样多的抛物面，其中该半径r不少于从抛物面的原点到焦点的标记为f的距离的50％、优选地不少于f的75％、更优选地不少于f的90％。圆柱体的半径r不需要小于抛物面镜的焦距，如图3中所示的情形，但是可以更大。
同时在图2中，示出透镜系统将光聚焦到检测器上，应当理解，这也可以替代为反射器系统，其可适当地相似于用于将激发光聚焦在照明区上的系统。这种系统在图4到6中示出。
在所示设备中，除了透镜系统44被相似于镜40但被设置成将荧光聚焦到现在定位了检测器46的侧的部分抛物面镜45所取代之外，所示出的部件与图2中的相同。如图6中所示，该设备包括机壳50，其具有位于皮肤上的基座板52并且包含如前面描述的限定照明区30的窗口54。机壳包括上和下半壳，其具有内部构成(formation)以包容(cradle)并支持光学部件，壳如所示地由螺钉固定在一起。
如图7中所示，机壳的基座表面可以与抛物面表面的轴成角α，其优选地不超过10°，更优选地不超过5°。这将给予一些附加的用于光学和电子部件的空间，但是也将导致设备的检测器端的某个附加的高度。此修改可以相关于如所示的在每个端使用镜的实施例并相关于图2的实施例而采用。另外，镜40的焦点可以与样品的位置不同，如图7上由距离δ所示出的，以补偿如检测皮肤下的荧光的情形中的样品或周围介质的辐射模式和散射特性。
如图8上所示，定位在镜40前方的包括一个或多个简单或复合透镜41的辅助透镜系统可以用于产生进一步的准直。
类似地，反射器的形状可以偏离抛物面的形状，以适应于如检测皮肤下的荧光的情形中的样品或周围介质的辐射模式和散射特性。如果这导致荧光发射的不完全准直，可以使用如所示的辅助透镜系统41执行进一步的准直。
可以使用的可替换的弯曲表面包括环形、非球形和双锥形表面。
对于由下面的等式限定的非球形表面
z = cr 2 1 + 1 - ( 1 + k ) c 2 r 2
c优选地在0.07到0.5的范围内，且k优选地在-1.5到-0.7的范围内，其中z是沿旋转轴的z坐标的“垂度(sag)”，c是曲率(半径R的倒数)，且k是圆锥常数，r是径向坐标。图9中示出对于圆锥常数的各个值的镜的形状。
图10中示出圆锥常数对所检测的光功率的影响。
照明区不需要是一个点或一个圆形区域，但是通过非抛物面反射器形状的使用的效果，可以横向于或纵向于反射器的轴延长照明区。
在此说明书中，除非明确地另外指示，词‘或(or)’以算符的意义使用，该算符在所陈述的条件的任一个或两个都满足时返回真值，与需要仅条件之一满足的算符‘异或(exclusive or)’相对。词‘包括(comprising)’以‘包括(including)’的意义使用，而不是意指‘由…构成(consisting of)’。

Claims (12)

1.用于在一表面处或下产生和检测荧光的设备，所述设备包括：
光源，用于沿在所述表面上延伸的光路引导荧光激发光；
反射器，具有三维弯曲的、类似壳的光反射界面，其被定位以接收从该光源沿所述光路的一部分在所述表面上通过的光，并相对于该光路的所述部分横向地反射所述光，以便将所述光聚焦在所述表面处或下的照明区上用于在所述区激励荧光，并且用于收集在所述区发射的荧光，并且反射并至少部分地准直所述光以沿该光路的所述部分返回；以及
检测器，用于接收在所述界面反射之后的以荧光发射的所述光。
2.如权利要求1的设备，进一步包括分束器，其反射由所述光源发射的光以将其传到所述反射器，并且从所述反射器接收荧光，并且将所述荧光传到所述检测器。
3.如权利要求2的设备，其中所述反射器、光源和检测器以一般是共面的方式设置，并且所述分束器具有处于与该反射器、光源和检测器的所述共面正交的平面上的平的反射界面。
4.如前面任何一项权利要求的设备，进一步包括激发滤光器，其从由该光源发射的光选择激发波长以传到所述反射器。
5.如前面任何一项权利要求的设备，进一步包括发射滤光器，其选择所发射的荧光波长以传到所述检测器。
6.如前面任何一项权利要求的设备，包括透镜或第二反射器，其将荧光聚焦到所述检测器上。
7.如前面任何一项权利要求的设备，其中所述反射器界面基本上具有部分抛物面、非球形、环形或双锥形表面的形式。
8.如权利要求7的设备，其中所述反射器界面由等式
z = cr 2 1 + 1 - ( 1 + k ) c 2 r 2
所限定，其中
c从0.07到0.5且k从-1.5到-0.7，其中z是沿旋转轴的z坐标的“垂度”，c是曲率(半径R的倒数)，k是圆锥常数且r是径向坐标。
9.如权利要求7或8所述的设备，其中所述反射器界面包括抛物面、非球形、环形或双锥形表面的部分，其通过由竖立在该照明区中央的直圆柱体切割抛物面、非球形、环形或双锥形表面而产生。
10.如权利要求7或8所述的设备，其中所述反射器界面基本上具有半抛物面的一部分的形式。
11.如前面任何一项权利要求的设备，进一步包括容纳该光源、反射器和检测器并且具有基座表面的机壳，该基座表面包含一窗口，用于将激发光传出该机壳并且将荧光接收到该机壳中，并且用于在使用中与在其处或其下发生所述荧光的所述表面接合。
12.如前面任何一项权利要求的设备，其中所述光路与由所述基座表面限定的平面成不大于10度的角。
CN200480038756XA 2003-12-23 2004-12-20 荧光计 Active CN1902475B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0329849.4A GB0329849D0 (en) 2003-12-23 2003-12-23 Fluorometers
GB0329849.4 2003-12-23
PCT/EP2004/014484 WO2005064318A1 (en) 2003-12-23 2004-12-20 Fluorometers

Publications (2)

Publication Number Publication Date
CN1902475A true CN1902475A (zh) 2007-01-24
CN1902475B CN1902475B (zh) 2010-11-10

Family

ID=30776389

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480038756XA Active CN1902475B (zh) 2003-12-23 2004-12-20 荧光计

Country Status (11)

Country Link
US (3) US7567347B2 (zh)
EP (1) EP1700101B1 (zh)
JP (1) JP4771545B2 (zh)
CN (1) CN1902475B (zh)
AU (1) AU2004309490B2 (zh)
CA (1) CA2550335A1 (zh)
DK (1) DK1700101T3 (zh)
GB (1) GB0329849D0 (zh)
NO (1) NO338185B1 (zh)
NZ (1) NZ548042A (zh)
WO (1) WO2005064318A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112005100A (zh) * 2018-03-12 2020-11-27 查珀尔希尔北卡罗来纳大学 用于荧光显微镜的光盘显微术

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6564105B2 (en) 2000-01-21 2003-05-13 Medtronic Minimed, Inc. Method and apparatus for communicating between an ambulatory medical device and a control device via telemetry using randomized data
US8152789B2 (en) 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US10080529B2 (en) 2001-12-27 2018-09-25 Medtronic Minimed, Inc. System for monitoring physiological characteristics
GB0329849D0 (en) * 2003-12-23 2004-01-28 Precisense As Fluorometers
GB0426823D0 (en) * 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
US9056165B2 (en) 2006-09-06 2015-06-16 Medtronic Minimed, Inc. Intelligent therapy recommendation algorithm and method of using the same
JP2010517693A (ja) 2007-02-06 2010-05-27 グルメトリクス， インコーポレイテッド 血中グルコース濃度のレシオメトリック測定のための光学系及び方法
JP5517919B2 (ja) 2007-05-10 2014-06-11 グルメトリクス、 インク． 即時血管内グルコース測定のための平衡非消費蛍光センサー
US8700114B2 (en) 2008-07-31 2014-04-15 Medtronic Minmed, Inc. Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
FR2936252B1 (fr) 2008-09-23 2010-11-05 Millipore Corp Dispositif pour l'analyse microbiologique.
FR2936251B1 (fr) 2008-09-23 2010-11-05 Millipore Corp Dispositif pour l'analyse microbiologique.
US8448322B2 (en) * 2009-01-24 2013-05-28 Thomas Leen Method and system for replacing the water cooled laser in a microplate reader
US8070723B2 (en) 2009-12-31 2011-12-06 Medtronic Minimed, Inc. Activity guard
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US9215995B2 (en) 2010-06-23 2015-12-22 Medtronic Minimed, Inc. Sensor systems having multiple probes and electrode arrays
KR101690535B1 (ko) 2010-10-06 2017-01-09 프로퓨사 인코퍼레이티드 조직-일체화 센서
WO2012074472A1 (en) * 2010-11-30 2012-06-07 Ge Healthcare Bio-Sciences Ab A luminescence detection scanner and a method for detecting luminescence
US8628510B2 (en) 2010-12-22 2014-01-14 Medtronic Minimed, Inc. Monitoring the operating health of a force sensor in a fluid infusion device
US11266823B2 (en) 2011-02-22 2022-03-08 Medtronic Minimed, Inc. Retractable sealing assembly for a fluid reservoir of a fluid infusion device
US8900206B2 (en) 2011-02-22 2014-12-02 Medtronic Minimed, Inc. Pressure vented fluid reservoir for a fluid infusion device
US9008744B2 (en) 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
US8795231B2 (en) 2011-05-10 2014-08-05 Medtronic Minimed, Inc. Automated reservoir fill system
US9013116B2 (en) 2011-05-12 2015-04-21 Excelitas Canada, Inc. Light source, pulse controller and method for programmabale pulse generation and synchronization of light emitting devices
US9642568B2 (en) 2011-09-06 2017-05-09 Medtronic Minimed, Inc. Orthogonally redundant sensor systems and methods
EP2760432B1 (en) 2011-09-27 2019-03-20 Medtronic Minimed, Inc. Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrombogenic agent
US9989522B2 (en) 2011-11-01 2018-06-05 Medtronic Minimed, Inc. Methods and materials for modulating start-up time and air removal in dry sensors
US8999720B2 (en) 2011-11-17 2015-04-07 Medtronic Minimed, Inc. Aqueous radiation protecting formulations and methods for making and using them
US9610401B2 (en) 2012-01-13 2017-04-04 Medtronic Minimed, Inc. Infusion set component with modular fluid channel element
CN104471379A (zh) * 2012-05-09 2015-03-25 生命技术公司 荧光成像的系统和方法
US9493807B2 (en) 2012-05-25 2016-11-15 Medtronic Minimed, Inc. Foldover sensors and methods for making and using them
US9357958B2 (en) 2012-06-08 2016-06-07 Medtronic Minimed, Inc. Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods
US9682188B2 (en) 2012-08-21 2017-06-20 Medtronic Minimed, Inc. Reservoir fluid volume estimator and medical device incorporating same
US9662445B2 (en) 2012-08-30 2017-05-30 Medtronic Minimed, Inc. Regulating entry into a closed-loop operating mode of an insulin infusion system
US10130767B2 (en) 2012-08-30 2018-11-20 Medtronic Minimed, Inc. Sensor model supervisor for a closed-loop insulin infusion system
WO2014074621A1 (en) 2012-11-07 2014-05-15 Glumetrics, Inc. Dry insertion and one-point in vivo calibration of an optical analyte sensor
US9265455B2 (en) 2012-11-13 2016-02-23 Medtronic Minimed, Inc. Methods and systems for optimizing sensor function by the application of voltage
US10194840B2 (en) 2012-12-06 2019-02-05 Medtronic Minimed, Inc. Microarray electrodes useful with analyte sensors and methods for making and using them
US10426383B2 (en) 2013-01-22 2019-10-01 Medtronic Minimed, Inc. Muting glucose sensor oxygen response and reducing electrode edge growth with pulsed current plating
US9140648B2 (en) 2013-03-12 2015-09-22 Ecolab Usa Inc. Fluorometer with multiple detection channels
JP6457998B2 (ja) 2013-03-14 2019-01-23 プロフサ，インコーポレイテッド 光信号を補正するための方法およびデバイス
US20140273181A1 (en) * 2013-03-15 2014-09-18 Biofire Diagnostics, Inc. Compact optical system for substantially simultaneous monitoring of samples in a sample array
US8984800B2 (en) * 2013-03-15 2015-03-24 Technology Sg, L.P. Radiating systems for affecting insect behavior
US9338819B2 (en) 2013-05-29 2016-05-10 Medtronic Minimed, Inc. Variable data usage personal medical system and method
JP2016523608A (ja) 2013-06-06 2016-08-12 プロフサ，インコーポレイテッド 埋込センサからの光信号を検出する装置及び方法
US10194864B2 (en) 2013-06-21 2019-02-05 Medtronic Minimed, Inc. Anchoring apparatus and method for attaching device on body
US9880528B2 (en) 2013-08-21 2018-01-30 Medtronic Minimed, Inc. Medical devices and related updating methods and systems
US9265881B2 (en) 2013-10-14 2016-02-23 Medtronic Minimed, Inc. Therapeutic agent injection device
US9375537B2 (en) 2013-10-14 2016-06-28 Medtronic Minimed, Inc. Therapeutic agent injection device
US8979808B1 (en) 2013-10-14 2015-03-17 Medtronic Minimed, Inc. On-body injector and method of use
US8979799B1 (en) 2013-10-14 2015-03-17 Medtronic Minimed, Inc. Electronic injector
US9936905B2 (en) 2013-10-25 2018-04-10 Medtronic Minimed, Inc. Sensor with optical interface
US9226709B2 (en) 2013-11-04 2016-01-05 Medtronic Minimed, Inc. ICE message system and method
US9267875B2 (en) 2013-11-21 2016-02-23 Medtronic Minimed, Inc. Accelerated life testing device and method
US9750877B2 (en) 2013-12-11 2017-09-05 Medtronic Minimed, Inc. Predicted time to assess and/or control a glycemic state
US9849240B2 (en) 2013-12-12 2017-12-26 Medtronic Minimed, Inc. Data modification for predictive operations and devices incorporating same
US10105488B2 (en) 2013-12-12 2018-10-23 Medtronic Minimed, Inc. Predictive infusion device operations and related methods and systems
US9649059B2 (en) 2013-12-16 2017-05-16 Medtronic Minimed, Inc. Methods and systems for improving the reliability of orthogonally redundant sensors
US10945630B2 (en) 2013-12-16 2021-03-16 Medtronic Minimed, Inc. Use of Electrochemical Impedance Spectroscopy (EIS) in gross failure analysis
US9143941B2 (en) 2013-12-18 2015-09-22 Medtronic Minimed, Inc. Secure communication by user selectable communication range
US9779226B2 (en) 2013-12-18 2017-10-03 Medtronic Minimed, Inc. Fingerprint enhanced authentication for medical devices in wireless networks
US9694132B2 (en) 2013-12-19 2017-07-04 Medtronic Minimed, Inc. Insertion device for insertion set
US9861748B2 (en) 2014-02-06 2018-01-09 Medtronic Minimed, Inc. User-configurable closed-loop notifications and infusion systems incorporating same
US9388805B2 (en) 2014-03-24 2016-07-12 Medtronic Minimed, Inc. Medication pump test device and method of use
US9689830B2 (en) 2014-04-03 2017-06-27 Medtronic Minimed, Inc. Sensor detection pads with integrated fuse
US9707336B2 (en) 2014-04-07 2017-07-18 Medtronic Minimed, Inc. Priming detection system and method of using the same
US10232113B2 (en) 2014-04-24 2019-03-19 Medtronic Minimed, Inc. Infusion devices and related methods and systems for regulating insulin on board
US9681828B2 (en) 2014-05-01 2017-06-20 Medtronic Minimed, Inc. Physiological characteristic sensors and methods for forming such sensors
US9901305B2 (en) 2014-06-13 2018-02-27 Medtronic Minimed, Inc. Physiological sensor history backfill system and method
US11185627B2 (en) 2014-07-21 2021-11-30 Medtronic Minimed, Inc. Smart connection interface
US9717845B2 (en) 2014-08-19 2017-08-01 Medtronic Minimed, Inc. Geofencing for medical devices
US20160051755A1 (en) 2014-08-25 2016-02-25 Medtronic Minimed, Inc. Low cost fluid delivery device
US9839753B2 (en) 2014-09-26 2017-12-12 Medtronic Minimed, Inc. Systems for managing reservoir chamber pressure
US10279126B2 (en) 2014-10-07 2019-05-07 Medtronic Minimed, Inc. Fluid conduit assembly with gas trapping filter in the fluid flow path
US9592335B2 (en) 2014-10-20 2017-03-14 Medtronic Minimed, Inc. Insulin pump data acquisition device
US9841014B2 (en) 2014-10-20 2017-12-12 Medtronic Minimed, Inc. Insulin pump data acquisition device and system
US9645408B2 (en) * 2014-10-31 2017-05-09 Everready Precision Ind. Corp. Surface mount device type laser module
US9731067B2 (en) 2014-11-25 2017-08-15 Medtronic Minimed, Inc. Mechanical injection pump and method of use
US9901675B2 (en) 2014-11-25 2018-02-27 Medtronic Minimed, Inc. Infusion set insertion device and method of use
US9943645B2 (en) 2014-12-04 2018-04-17 Medtronic Minimed, Inc. Methods for operating mode transitions and related infusion devices and systems
US9636453B2 (en) 2014-12-04 2017-05-02 Medtronic Minimed, Inc. Advance diagnosis of infusion device operating mode viability
US10307535B2 (en) 2014-12-19 2019-06-04 Medtronic Minimed, Inc. Infusion devices and related methods and systems for preemptive alerting
US9717848B2 (en) 2015-01-22 2017-08-01 Medtronic Minimed, Inc. Data derived pre-bolus delivery
US9872954B2 (en) 2015-03-02 2018-01-23 Medtronic Minimed, Inc. Belt clip
US10307528B2 (en) 2015-03-09 2019-06-04 Medtronic Minimed, Inc. Extensible infusion devices and related methods
US10449298B2 (en) 2015-03-26 2019-10-22 Medtronic Minimed, Inc. Fluid injection devices and related methods
US10130757B2 (en) 2015-05-01 2018-11-20 Medtronic Minimed, Inc. Method and system for leakage detection in portable medical devices
US9999721B2 (en) 2015-05-26 2018-06-19 Medtronic Minimed, Inc. Error handling in infusion devices with distributed motor control and related operating methods
US10197545B2 (en) * 2015-07-29 2019-02-05 Advanced Sensors Limited Method and apparatus for measurement of a material in a liquid through absorption of light
US10543314B2 (en) 2015-08-21 2020-01-28 Medtronic Minimed, Inc. Personalized parameter modeling with signal calibration based on historical data
US10201657B2 (en) 2015-08-21 2019-02-12 Medtronic Minimed, Inc. Methods for providing sensor site rotation feedback and related infusion devices and systems
US10293108B2 (en) 2015-08-21 2019-05-21 Medtronic Minimed, Inc. Infusion devices and related patient ratio adjustment methods
US10117992B2 (en) 2015-09-29 2018-11-06 Medtronic Minimed, Inc. Infusion devices and related rescue detection methods
US9992818B2 (en) 2015-10-06 2018-06-05 Medtronic Minimed, Inc. Protocol translation device
US9757511B2 (en) 2015-10-19 2017-09-12 Medtronic Minimed, Inc. Personal medical device and method of use with restricted mode challenge
US11501867B2 (en) 2015-10-19 2022-11-15 Medtronic Minimed, Inc. Medical devices and related event pattern presentation methods
US11666702B2 (en) 2015-10-19 2023-06-06 Medtronic Minimed, Inc. Medical devices and related event pattern treatment recommendation methods
US10146911B2 (en) 2015-10-23 2018-12-04 Medtronic Minimed, Inc. Medical devices and related methods and systems for data transfer
US10037722B2 (en) 2015-11-03 2018-07-31 Medtronic Minimed, Inc. Detecting breakage in a display element
US10827959B2 (en) 2015-11-11 2020-11-10 Medtronic Minimed, Inc. Sensor set
US9848805B2 (en) 2015-12-18 2017-12-26 Medtronic Minimed, Inc. Biostable glucose permeable polymer
US10349872B2 (en) 2015-12-28 2019-07-16 Medtronic Minimed, Inc. Methods, systems, and devices for sensor fusion
US10327686B2 (en) 2015-12-28 2019-06-25 Medtronic Minimed, Inc. Sensor systems, devices, and methods for continuous glucose monitoring
US10327680B2 (en) 2015-12-28 2019-06-25 Medtronic Minimed, Inc. Sensor systems, devices, and methods for continuous glucose monitoring
US20170181672A1 (en) 2015-12-28 2017-06-29 Medtronic Minimed, Inc. Sensor systems, devices, and methods for continuous glucose monitoring
US10790054B1 (en) 2016-12-07 2020-09-29 Medtronic Minimed, Inc. Method and apparatus for tracking of food intake and other behaviors and providing relevant feedback
WO2017132690A1 (en) 2016-01-28 2017-08-03 Savor Labs, Inc. Method and apparatus for tracking of food intake and other behaviors and providing relevant feedback
US10413183B2 (en) 2016-04-08 2019-09-17 Medtronic Minimed, Inc. Insertion device
US10765348B2 (en) 2016-04-08 2020-09-08 Medtronic Minimed, Inc. Sensor and transmitter product
US10765369B2 (en) 2016-04-08 2020-09-08 Medtronic Minimed, Inc. Analyte sensor
US10589038B2 (en) 2016-04-27 2020-03-17 Medtronic Minimed, Inc. Set connector systems for venting a fluid reservoir
US9970893B2 (en) 2016-04-28 2018-05-15 Medtronic Minimed, Inc. Methods, systems, and devices for electrode capacitance calculation and application
US10426389B2 (en) 2016-04-28 2019-10-01 Medtronic Minimed, Inc. Methods, systems, and devices for electrode capacitance calculation and application
US10324058B2 (en) 2016-04-28 2019-06-18 Medtronic Minimed, Inc. In-situ chemistry stack for continuous glucose sensors
US10086133B2 (en) 2016-05-26 2018-10-02 Medtronic Minimed, Inc. Systems for set connector assembly with lock
US9968737B2 (en) 2016-05-26 2018-05-15 Medtronic Minimed, Inc. Systems for set connector assembly with lock
US10086134B2 (en) 2016-05-26 2018-10-02 Medtronic Minimed, Inc. Systems for set connector assembly with lock
US11179078B2 (en) 2016-06-06 2021-11-23 Medtronic Minimed, Inc. Polycarbonate urea/urethane polymers for use with analyte sensors
US11134872B2 (en) 2016-06-06 2021-10-05 Medtronic Minimed, Inc. Thermally stable glucose limiting membrane for glucose sensors
US10485924B2 (en) 2016-09-06 2019-11-26 Medtronic Minimed, Inc. Pump clip for a fluid infusion device
US10709834B2 (en) 2016-12-21 2020-07-14 Medtronic Minimed, Inc. Medication fluid infusion set component with integrated physiological analyte sensor, and corresponding fluid infusion device
US10854324B2 (en) 2016-12-21 2020-12-01 Medtronic Minimed, Inc. Infusion systems and methods for prospective closed-loop adjustments
US10272201B2 (en) 2016-12-22 2019-04-30 Medtronic Minimed, Inc. Insertion site monitoring methods and related infusion devices and systems
WO2018119400A1 (en) 2016-12-22 2018-06-28 Profusa, Inc. System and single-channel luminescent sensor for and method of determining analyte value
US11197949B2 (en) 2017-01-19 2021-12-14 Medtronic Minimed, Inc. Medication infusion components and systems
US10821225B2 (en) 2017-01-20 2020-11-03 Medtronic Minimed, Inc. Cannulas for drug delivery devices
US10552580B2 (en) 2017-02-07 2020-02-04 Medtronic Minimed, Inc. Infusion system consumables and related calibration methods
US10646649B2 (en) 2017-02-21 2020-05-12 Medtronic Minimed, Inc. Infusion devices and fluid identification apparatuses and methods
US11134868B2 (en) 2017-03-17 2021-10-05 Medtronic Minimed, Inc. Metal pillar device structures and methods for making and using them in electrochemical and/or electrocatalytic applications
US11229406B2 (en) 2017-03-24 2022-01-25 Medtronic Minimed, Inc. Patient-specific glucose prediction systems and methods
US10792378B2 (en) 2017-04-28 2020-10-06 Medtronics Minimed, Inc. Using a blue-shifted reference dye in an optical glucose assay
US10543288B2 (en) 2017-04-28 2020-01-28 Medtronic Minimed, Inc. Modified-dextrans for use in optical glucose assays
US11512384B2 (en) 2017-05-11 2022-11-29 Medtronic Minimed, Inc. Analyte sensors and methods for fabricating analyte sensors
US10856784B2 (en) 2017-06-30 2020-12-08 Medtronic Minimed, Inc. Sensor initialization methods for faster body sensor response
US10596295B2 (en) 2017-08-28 2020-03-24 Medtronic Minimed, Inc. Adhesive patch arrangement for a physiological characteristic sensor, and related sensor assembly
US11412960B2 (en) 2017-08-28 2022-08-16 Medtronic Minimed, Inc. Pedestal for sensor assembly packaging and sensor introducer removal
US11344235B2 (en) 2017-09-13 2022-05-31 Medtronic Minimed, Inc. Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output
US10874300B2 (en) 2017-09-26 2020-12-29 Medtronic Minimed, Inc. Waferscale physiological characteristic sensor package with integrated wireless transmitter
US10525244B2 (en) 2017-09-28 2020-01-07 Medtronic Minimed, Inc. Microneedle arrays and methods for fabricating microneedle arrays
US10524730B2 (en) 2017-09-28 2020-01-07 Medtronic Minimed, Inc. Medical devices with microneedle arrays and methods for operating such medical devices
US11676734B2 (en) 2017-11-15 2023-06-13 Medtronic Minimed, Inc. Patient therapy management system that leverages aggregated patient population data
US11213230B2 (en) 2017-12-13 2022-01-04 Medtronic Minimed, Inc. Optional sensor calibration in continuous glucose monitoring
US11471082B2 (en) 2017-12-13 2022-10-18 Medtronic Minimed, Inc. Complex redundancy in continuous glucose monitoring
US11439352B2 (en) 2018-01-17 2022-09-13 Medtronic Minimed, Inc. Medical device with adhesive patch longevity
US11186859B2 (en) 2018-02-07 2021-11-30 Medtronic Minimed, Inc. Multilayer electrochemical analyte sensors and methods for making and using them
US11220735B2 (en) 2018-02-08 2022-01-11 Medtronic Minimed, Inc. Methods for controlling physical vapor deposition metal film adhesion to substrates and surfaces
US11583213B2 (en) 2018-02-08 2023-02-21 Medtronic Minimed, Inc. Glucose sensor electrode design
CN108414487B (zh) * 2018-03-08 2021-02-12 北京航空航天大学 一种针对固体出射荧光的光学收集方法及系统
US11672446B2 (en) 2018-03-23 2023-06-13 Medtronic Minimed, Inc. Insulin delivery recommendations based on nutritional information
US11147919B2 (en) 2018-04-23 2021-10-19 Medtronic Minimed, Inc. Methodology to recommend and implement adjustments to a fluid infusion device of a medication delivery system
US11158413B2 (en) 2018-04-23 2021-10-26 Medtronic Minimed, Inc. Personalized closed loop medication delivery system that utilizes a digital twin of the patient
US11367526B2 (en) 2018-05-07 2022-06-21 Medtronic Minimed, Inc. Proactive patient guidance using augmented reality
US11761077B2 (en) 2018-08-01 2023-09-19 Medtronic Minimed, Inc. Sputtering techniques for biosensors
US11122697B2 (en) 2018-08-07 2021-09-14 Medtronic Minimed, Inc. Method of fabricating an electronic medical device, including overmolding an assembly with thermoplastic material
US11021731B2 (en) 2018-08-23 2021-06-01 Medtronic Minimed, Inc. Analyte sensing layers, analyte sensors and methods for fabricating the same
US10828419B2 (en) 2018-09-04 2020-11-10 Medtronic Minimed, Inc. Infusion set with pivoting metal cannula and strain relief
US11547799B2 (en) 2018-09-20 2023-01-10 Medtronic Minimed, Inc. Patient day planning systems and methods
US10894126B2 (en) 2018-09-28 2021-01-19 Medtronic Minimed, Inc. Fluid infusion system that automatically determines and delivers a correction bolus
US11097052B2 (en) 2018-09-28 2021-08-24 Medtronic Minimed, Inc. Insulin infusion device with configurable target blood glucose value for automatic basal insulin delivery operation
US11071821B2 (en) 2018-09-28 2021-07-27 Medtronic Minimed, Inc. Insulin infusion device with efficient confirmation routine for blood glucose measurements
US10980942B2 (en) 2018-09-28 2021-04-20 Medtronic Minimed, Inc. Infusion devices and related meal bolus adjustment methods
US20200116748A1 (en) 2018-10-11 2020-04-16 Medtronic Minimed, Inc. Systems and methods for measurement of fluid delivery
US10946140B2 (en) 2018-10-11 2021-03-16 Medtronic Minimed, Inc. Systems and methods for measurement of fluid delivery
US20200135320A1 (en) 2018-10-31 2020-04-30 Medtronic Minimed, Inc. Automated detection of a physical behavior event and corresponding adjustment of a medication dispensing system based on historical events
US20200289373A1 (en) 2018-10-31 2020-09-17 Medtronic Minimed, Inc. Automated detection of a physical behavior event and corresponding adjustment of a physiological characteristic sensor device
US11363986B2 (en) 2018-10-31 2022-06-21 Medtronic Minimed, Inc. Automated detection of a physical behavior event and corresponding adjustment of a medication dispensing system
US11367517B2 (en) 2018-10-31 2022-06-21 Medtronic Minimed, Inc. Gesture-based detection of a physical behavior event based on gesture sensor data and supplemental information from at least one external source
US11382541B2 (en) 2018-11-16 2022-07-12 Medtronic Minimed, Inc. Miniaturized analyte sensor
US11540750B2 (en) 2018-12-19 2023-01-03 Medtronic Minimed, Inc Systems and methods for physiological characteristic monitoring
US11439752B2 (en) 2019-02-01 2022-09-13 Medtronic Minimed, Inc. Methods and devices for occlusion detection using actuator sensors
US11389587B2 (en) 2019-02-06 2022-07-19 Medtronic Minimed, Inc. Patient monitoring systems and related presentation methods
US11191899B2 (en) 2019-02-12 2021-12-07 Medtronic Minimed, Inc. Infusion systems and related personalized bolusing methods
US11311215B2 (en) 2019-04-04 2022-04-26 Medtronic Minimed, Inc. Measurement of device materials using non-Faradaic electrochemical impedance spectroscopy
US11224361B2 (en) 2019-04-23 2022-01-18 Medtronic Minimed, Inc. Flexible physiological characteristic sensor assembly
US11317867B2 (en) 2019-04-23 2022-05-03 Medtronic Minimed, Inc. Flexible physiological characteristic sensor assembly
US10939488B2 (en) 2019-05-20 2021-03-02 Medtronic Minimed, Inc. Method and system for controlling communication between devices of a wireless body area network for an medical device system
US11642454B2 (en) 2019-06-06 2023-05-09 Medtronic Minimed, Inc. Fluid infusion systems
US11448611B2 (en) 2019-07-03 2022-09-20 Medtronic Minimed, Inc. Structurally reinforced sensor and method for manufacturing the same
US11617828B2 (en) 2019-07-17 2023-04-04 Medtronic Minimed, Inc. Reservoir connection interface with detectable signature
US11718865B2 (en) 2019-07-26 2023-08-08 Medtronic Minimed, Inc. Methods to improve oxygen delivery to implantable sensors
US11523757B2 (en) 2019-08-01 2022-12-13 Medtronic Minimed, Inc. Micro-pillar working electrodes design to reduce backflow of hydrogen peroxide in glucose sensor
US11883208B2 (en) 2019-08-06 2024-01-30 Medtronic Minimed, Inc. Machine learning-based system for estimating glucose values based on blood glucose measurements and contextual activity data
US11617522B2 (en) 2019-08-06 2023-04-04 Medtronic Minimed, Inc. Sensor inserter with disposal lockout state
US11724045B2 (en) 2019-08-21 2023-08-15 Medtronic Minimed, Inc. Connection of a stopper and piston in a fluid delivery device
US11571515B2 (en) 2019-08-29 2023-02-07 Medtronic Minimed, Inc. Controlling medical device operation and features based on detected patient sleeping status
US11565044B2 (en) 2019-09-12 2023-01-31 Medtronic Minimed, Inc. Manufacturing controls for sensor calibration using fabrication measurements
US11654235B2 (en) 2019-09-12 2023-05-23 Medtronic Minimed, Inc. Sensor calibration using fabrication measurements
US11241537B2 (en) 2019-09-20 2022-02-08 Medtronic Minimed, Inc. Contextual personalized closed-loop adjustment methods and systems
US11213623B2 (en) 2019-09-20 2022-01-04 Medtronic Minimed, Inc. Infusion systems and related personalized bolusing methods
US11511099B2 (en) 2019-10-08 2022-11-29 Medtronic Minimed, Inc. Apparatus for detecting mating of a cap with a fluid delivery device and method
US11638545B2 (en) 2019-10-16 2023-05-02 Medtronic Minimed, Inc. Reducing sensor foreign body response via high surface area metal structures
US11496083B2 (en) 2019-11-15 2022-11-08 Medtronic Minimed, Inc. Devices and methods for controlling electromechanical actuators
US11944784B2 (en) 2019-11-18 2024-04-02 Medtronic Minimed, Inc. Combined analyte sensor and infusion set
US11324881B2 (en) 2019-11-21 2022-05-10 Medtronic Minimed, Inc. Systems for wearable infusion port and associated pump
US11559624B2 (en) 2019-11-21 2023-01-24 Medtronic Minimed, Inc. Systems for wearable infusion port and associated pump
US20210170103A1 (en) 2019-12-09 2021-06-10 Medtronic Minimed, Inc. Methods and systems for real-time sensor measurement simulation
US11786655B2 (en) 2019-12-13 2023-10-17 Medtronic Minimed, Inc. Context-sensitive predictive operation of a medication delivery system in response to gesture-indicated activity changes
US11488700B2 (en) 2019-12-13 2022-11-01 Medtronic Minimed, Inc. Medical device configuration procedure guidance responsive to detected gestures
WO2021119549A1 (en) 2019-12-13 2021-06-17 Medtronic Minimed, Inc. Method and system for training a mathematical model of a user based on data received from a discrete insulin therapy system
US11938301B2 (en) 2019-12-13 2024-03-26 Medtronic Minimed, Inc. Controlling medication delivery system operation and features based on automatically detected muscular movements
US11690573B2 (en) 2019-12-18 2023-07-04 Medtronic Minimed, Inc. Systems for skin patch gravity resistance
US11375955B2 (en) 2019-12-18 2022-07-05 Medtronic Minimed, Inc. Systems for skin patch gravity resistance
US11821022B2 (en) 2019-12-23 2023-11-21 Medtronic Minimed, Inc. Ethylene oxide absorption layer for analyte sensing and method
US11244753B2 (en) 2020-01-30 2022-02-08 Medtronic Minimed, Inc. Activity monitoring systems and methods
US11957488B2 (en) 2020-02-07 2024-04-16 Medtronic Minimed, Inc. Systems for medical device breathability
US11833327B2 (en) 2020-03-06 2023-12-05 Medtronic Minimed, Inc. Analyte sensor configuration and calibration based on data collected from a previously used analyte sensor
USD958167S1 (en) 2020-03-23 2022-07-19 Companion Medical, Inc. Display screen with graphical user interface
USD958817S1 (en) 2020-03-31 2022-07-26 Medtronic Minimed, Inc. Display screen with graphical user interface
US11596359B2 (en) 2020-04-09 2023-03-07 Medtronic Minimed, Inc. Methods and systems for mitigating sensor error propagation
US11583631B2 (en) 2020-04-23 2023-02-21 Medtronic Minimed, Inc. Intuitive user interface features and related functionality for a therapy delivery system
US11690955B2 (en) 2020-04-23 2023-07-04 Medtronic Minimed, Inc. Continuous analyte sensor quality measures and related therapy actions for an automated therapy delivery system
US11272884B2 (en) 2020-06-04 2022-03-15 Medtronic Minimed, Inc. Liner for adhesive skin patch
US11650248B2 (en) 2020-07-28 2023-05-16 Medtronic Minimed, Inc. Electrical current measurement system
US11960311B2 (en) 2020-07-28 2024-04-16 Medtronic Minimed, Inc. Linear voltage regulator with isolated supply current
US11445807B2 (en) 2020-07-31 2022-09-20 Medtronic Minimed, Inc. Pump clip with tube clamp for a fluid infusion device
US11839743B2 (en) 2020-10-07 2023-12-12 Medtronic Minimed, Inc. Graphic user interface for automated infusate delivery
US11737783B2 (en) 2020-10-16 2023-08-29 Medtronic Minimed, Inc. Disposable medical device introduction system
US11844930B2 (en) 2020-10-29 2023-12-19 Medtronic Minimed, Inc. User-mountable electronic device with accelerometer-based activation feature
US11806503B2 (en) 2020-10-29 2023-11-07 Medtronic Minimed, Inc. Removable wearable device and related attachment methods
US11534086B2 (en) 2020-10-30 2022-12-27 Medtronic Minimed, Inc. Low-profile wearable medical device
US11951281B2 (en) 2020-11-11 2024-04-09 Medtronic Minimed, Inc. Fluid conduit insertion devices
CN116830208A (zh) 2021-02-02 2023-09-29 美敦力迷你迈德公司 生理数据的动态调整
US11904146B2 (en) 2021-06-08 2024-02-20 Medtronic Minimed, Inc. Medicine injection devices, systems, and methods for medicine administration and tracking
US11792714B2 (en) 2021-06-16 2023-10-17 Medtronic Minimed, Inc. Medicine administration in dynamic networks
US11817285B2 (en) 2021-09-02 2023-11-14 Medtronic Minimed, Inc. Ingress-tolerant input devices comprising sliders
US11587742B1 (en) 2021-09-02 2023-02-21 Medtronic Minimed, Inc. Ingress-tolerant input devices
US11896447B2 (en) 2022-03-14 2024-02-13 Medtronic Minimed, Inc. Safeguards against separation from portable medicine delivery devices

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4679562A (en) 1983-02-16 1987-07-14 Cardiac Pacemakers, Inc. Glucose sensor
US5431160A (en) 1989-07-19 1995-07-11 University Of New Mexico Miniature implantable refillable glucose sensor and material therefor
EP0429907B1 (de) 1989-11-21 1994-06-01 Bayer Ag Optischer Biosensor
US5342789A (en) 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
CA2053449A1 (en) 1990-10-16 1992-04-17 Henry K. Hui Optical fiber ph microsensor and method of manufacture
US6256522B1 (en) 1992-11-23 2001-07-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Sensors for continuous monitoring of biochemicals and related method
JP2915294B2 (ja) * 1993-10-27 1999-07-05 川崎製鉄株式会社 金属材料表面の塗油量測定方法および装置
EP0736767A1 (de) * 1995-04-07 1996-10-09 Ciba-Geigy Ag Optische Detektionsvorrichtung für analytische Messungen an chemischen Substanzen
US6002954A (en) 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
US5801828A (en) * 1996-11-14 1998-09-01 Detections Unlimited, Inc. Apparatus and method for fluorescence spectroscopy of remote sample
DE19704731B4 (de) * 1997-02-07 2006-07-27 Stratec Biomedical Systems Ag Meßgerät zur Durchführung von Lumineszenzmessungen
GB9814506D0 (en) 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
JP3405252B2 (ja) * 1999-02-16 2003-05-12 理化学研究所 生体試料観察装置
US6355934B1 (en) * 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
AU6075100A (en) * 1999-07-07 2001-01-30 Ljl Biosystems, Inc. Light detection device
JP2001074656A (ja) * 1999-09-03 2001-03-23 Fuji Photo Film Co Ltd 画像情報読取装置
DE69940787D1 (de) * 1999-09-30 2009-06-04 Diagnoptics Holding B V Verfahren und gerät zur bestimmung der autofluoreszenz von hautgewebe
GB0025147D0 (en) 2000-10-13 2000-11-29 Torsana Diabetes Diagnostics A Optical sensor for in situ measurement of analytes
AU2002251944A1 (en) 2001-02-15 2002-09-04 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
US6670617B2 (en) 2001-06-28 2003-12-30 Ondeo Nalco Company Mirror fluorometer
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
MXPA04008713A (es) * 2002-03-08 2006-02-24 Sensys Medical Inc Aparato compacto para la medicion no invasiva de glucosa a traves de espectroscopia del infrarrojo cercano.
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
US6809859B2 (en) * 2002-07-31 2004-10-26 Semrock, Inc. Optical filter and fluorescence spectroscopy system incorporating the same
JP2006507503A (ja) * 2002-11-21 2006-03-02 シーデックス， インコーポレイテッド 紫外蛍光を使用して、分子種を検出し、検査し、分類するための方法および装置
US7297548B2 (en) 2003-03-28 2007-11-20 Terumo Kabushiki Kaisha Solid-phase saccharide sensing compounds
GB0329849D0 (en) 2003-12-23 2004-01-28 Precisense As Fluorometers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112005100A (zh) * 2018-03-12 2020-11-27 查珀尔希尔北卡罗来纳大学 用于荧光显微镜的光盘显微术

Also Published As

Publication number Publication date
GB0329849D0 (en) 2004-01-28
US7567347B2 (en) 2009-07-28
US8305580B2 (en) 2012-11-06
DK1700101T3 (en) 2015-07-20
AU2004309490A1 (en) 2005-07-14
CA2550335A1 (en) 2005-07-14
WO2005064318A1 (en) 2005-07-14
EP1700101A1 (en) 2006-09-13
NO20063289L (no) 2006-07-14
AU2004309490B2 (en) 2010-03-04
EP1700101B1 (en) 2015-07-01
NZ548042A (en) 2009-02-28
US20100090126A1 (en) 2010-04-15
US20110089341A1 (en) 2011-04-21
JP2007515645A (ja) 2007-06-14
CN1902475B (zh) 2010-11-10
JP4771545B2 (ja) 2011-09-14
US7869042B2 (en) 2011-01-11
US20070153279A1 (en) 2007-07-05
NO338185B1 (no) 2016-08-01

Similar Documents

Publication Publication Date Title
CN1902475A (zh) 荧光计
JP5705432B2 (ja) 光学アッセイシステム
ES2635094T3 (es) Procedimientos y aparatos para la formación confocal de imágenes
US7750316B2 (en) Polymer biochip for detecting fluorescence
US20060134775A1 (en) Systems, illumination subsystems, and methods for increasing fluorescence emitted by a fluorophore
RU2182328C2 (ru) Флуоресцентный микроскоп
JP4259762B2 (ja) 光を検出するための光学的構成
CN1541078A (zh) 天然皮肤的鉴别方法和装置
CN1821753A (zh) 荧光测定装置
US20100136709A1 (en) Receptacle and method for the detection of fluorescence
US7209237B2 (en) Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same
CN100338445C (zh) 光学部件、使用该部件的光检测装置和方法、及分析方法
CN1902663A (zh) 用于票据确认装置的反射式光传感器
WO2011062548A1 (en) System and method for increased fluorescence detection
KR20030037314A (ko) 바이오 칩 분석을 위한 형광 영상 분석장치
JP2009019961A (ja) 蛍光検出システム
CN1804581A (zh) 一种用于集成生化芯片的光谱微传感器
US11533392B1 (en) Solid-state illumination system for compact microscopy

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant