CN1950049A - 液体药物医疗装置 - Google Patents

液体药物医疗装置 Download PDF

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CN1950049A
CN1950049A CNA2005800136458A CN200580013645A CN1950049A CN 1950049 A CN1950049 A CN 1950049A CN A2005800136458 A CNA2005800136458 A CN A2005800136458A CN 200580013645 A CN200580013645 A CN 200580013645A CN 1950049 A CN1950049 A CN 1950049A
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syringe
adapter
needle shield
needle
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CN100560046C (zh
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佛莱迪·辛格
伊高·丹那贝尔格
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Medimop Medical Projects Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A61J1/2062—Connecting means having multiple connecting ports with directional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
    • A61M2005/3215—Tools enabling the cap placement

Abstract

本发明涉及液体药物医疗装置，用以液体药物的给药，以及安全移除针头套的针头套移除装置。

Description

液体药物医疗装置
发明领域
本发明涉及液体药物医疗装置，以及针头套移除装置。
发明背景
共同拥有的PCT国际申请No.PCT/US96/03732在PCT国际公布No.WO96/29113中公布，图解并描述了用于液体药物给药的流体控制装置。该流体控制装置尤其包括现在可以从麦迪麦珀医疗工程有限公司，让纳纳，以色列(Medimop Medical Projects Ltd，Ra′anana，Israel)(www.medimop.com)处购买的流体控制器，注册商标是MIXJECT。MIXJECT流体控制装置具有一个纵轴，并且包括一个带有用来接受注射器的注射器仓的基本部件，以及塑料套管形式的配药口，一根注射针等等。该基本部件旋转支撑一其上耦合有可手动旋转的小瓶转接器的流量调节部件，以使它在用于连接注射器仓与置于小瓶转接器内的小瓶内的第一流量调节位置和用于连接注射器仓与配药口的第二流量调节位置之间旋转(见WO96/29113的图1-19)。小瓶转接器(vial adapter)优选地通过旋转螺纹，可在第二流量调节位置上，沿着横向指向流体控制装置的纵轴的拆卸线从基本部件上拆卸下来(见WO96/29113的图11-16)。
常规的注射针头具有母螺旋接头(female Luer connector)用以严密地安装在具有公螺旋接头(male Luer connector)的常规注射器上。一些注射器配有注射器尖端，其尖端的远端有突出的缘，以防止常规的注射针头正向安装在其上。但是，这类的注射器不合宜地排除了与其它具有母螺旋接头的转移装置，例如，可以从麦迪麦珀医疗工程有限公司，让纳纳，以色列(Medimop Medical Projects Ltd，Ra′anana，Israel)处购买到的小瓶转接器，联合使用的可能。而且，常规的注射针头常常配备有针头套以防针刺伤事故。针头套依靠摩擦力安装在注射针头上，经常难于去除，部分原因归咎于它们的小尺寸而使其难以抓握。针头套移除装置的例子在专利EP 0 518 397发明名称“Device for the removal and replacement ofa needle shield”，WO02/09797发明名称“Pen Needle and Safety Shield System”，和WO2003/051423发明名称“Needle Closure System Removal Device”中有图解和描述。
发明内容
根据本发明的第一方面，提供了一种液体药物医疗装置，用于与生理溶液源及药物容器联用，用于液体药物的给药，该装置具有一纵轴，并包含：
(a)一主体部件，具有与生理溶液源流体连接的第一开口；
(b)一流量调节部件，围绕与纵轴同方向的旋转轴可转动地安装在所述的主体部件上，并具有第一主导流管和第二导流管，其基本平行于但非同轴于所述的旋转轴，并且分别终止于第二开口，还有液体药物给药的第三开口；及
(c)一手动可旋转转接器，具有流体导管部件，该部件具有一近端与所述的第二开口流体连接，还有一远端延伸到附着于所述转接器的药物容器内，该手动可旋转转接器固定于所述的流量调节部件，以使它在用于连接所述第一开口与所述第二开口的第一流量调节位置，和用于连接所述第一开口与所述第三开口的第二流量调节位置之间旋转。
本发明的液体药物医疗装置优选地包含一转接器，该转接器沿着与药物医疗装置的纵轴同方向的拆卸线(line of detachment)是可拆卸的，因此提供了比迄今上述具有横向拆卸线的MIXJECT流体控制器更方便的线上分离。这些具有可拆卸转接器的液体药物医疗装置结构更紧凑，且改善了操作性能，优选地，还包括药物分配器，例如，内置式的针头，雾化器等，与它们的第三开口流体连接，以适于液体药物的自身给药。可设计不同的转接器来适配使用不同的药物容器，尤其包括小瓶、安瓿等等。
据本发明的第二方面，提供了一种与注射器联用的液体药物医疗装置，该注射器具有注射器末端，其远端具有突出的缘，还有一有橡皮塞子的小药瓶，该装置包括一转接器用于卡接(snap fitting)到该小瓶上，还包括一个中空的穿刺部件，用于刺穿卡接到转换器上的小瓶的橡皮塞子，还有一个弹性管与所述的穿刺部件流体连接并具有能严密覆盖注射器的突出的缘，可使在注射器和小药瓶之间形成流体连接的远端。因此，该液体药物移送装置适于与注射器方便地联用，避免了滑动地安装在其上的具有母螺旋接头的常规针头。
据本发明的第三方面，提供了一种针头套移除装置，与注射针被针头套保护着的液体药物医疗装置联用，该注射针包括一个具有凸缘的针座，和一根针杆，该针头套移除装置包括：
(a)基本部件，包括至少两个间隔分开的终止于末端底面(end face)的支持腿；及
(b)一针头套释放部件，包括一对反向的把手，和至少两个间隔分开的紧固腿，从所述的至少两个间隔分开的支撑腿中间插入，并且终止于针头套的夹爪(grip)，使其支撑靠在注射针的凸缘，用以将针头套从注射针头上滑动地取下来，
所述的针头套释放部件，从初始的向外偏移位置(outwardly biased position)(其中所述的针头套夹爪基本上平齐于所述的末端底面)和缩进位置(其中所述的针头套夹爪相对于所述的末端底面向内排列)沿着所述的基本部件滑行移动，
所述的针头套移除装置滑动地安装在液体药物医疗装置上以将针头套包封在其内，因此，针头套释放部件正向地推进所述的缩进位置，抽出针头套，于是就安全地露出针杆来。
附图的简要说明
为了理解本发明，并理解它是如何在实践中实施的，下面将描述优选的实施例，本发明的实施例不仅限与此，参考附图，图中相同的部件相同编号，其中：
图1是据本发明的第一方面的液体药物医疗装置的视图，一个预先充满的注射器，一个盛有药物浓缩剂的小瓶，和一个原来包装液体药物医疗装置的空的外壳；
图2是在取出液体药物医疗装置之前，图1中的包装打开时的俯视图；
图3是图1的液体药物医疗装置的部件分解图，其具有一内置式的注射针用于将液体药物给病人用药；
图4A和4B是图1中的液体药物医疗装置在图2中的设定位置，分别沿着A-A和B-B线的的横截面图；
图5A-5F显示了使用图1中的液体药物医疗装置来准备液体药物为给病人用药；
图6是本发明的包含雾化器的液体药物医疗装置的第二优选实施例的横截面图；
图7是本发明的包含药物分配器口的液体药物医疗装置的第三优选实施例的横截面图；
图8是据本发明的第二方面的液体药物医疗装置的透视图，注射器的注射器末端有一突出的缘，还有盛有药物浓缩剂的小瓶；
图9是图8的液体药物医疗装置沿着图8中的线C-C的第一实施例的纵向横截面图；
图10是图8的液体药物医疗装置沿着图8中的线C-C的第二实施例的纵向横截面图；
图11是图8的液体药物医疗装置沿着图8中的线C-C的第三实施例的纵向横截面图；
图12本发明的第三方面的一个具有防护的针头的注射器和一个针头套移除装置的透视图；
图13是图12的针头套移除装置的部件分解图；
图14是图12的针头套移除装置在其第一操作状态的纵向横截面图；
图15是图12的针头套移除装置在其第二操作状态的纵向横截面图；
图16显示了针头套移除装置放在具有防护针头的注射器上的纵向横截面图；
图17显示了将针头套从注射器上除去，露出其针头的纵向横截面图；及
图18显示了针头套移除装置与针头一起从注射器移除的纵向横截面图。
本发明优选的实施例的具体说明
图1显示了液体药物医疗装置10，用于与具有顺时针方向螺纹的公螺旋锁紧接头12的典型的预先充满的注射器11联用，及一有橡皮塞14的小瓶13，其内盛有干粉状的药物浓缩剂16，不过，同样也可以盛液体药物浓缩剂。液体药物医疗装置10被设计用于将小瓶13中的药物浓缩剂重新溶解，以便抽吸到注射器11中，用于通常的自身给药。液体药物医疗装置10通常包装于一个密封的灭菌无热源包装17中，其包括一个剥去盖19的透明的塑料包装壳18，其显示部分剥开，以便取出液体药物医疗装置10。包装壳18具有一个纵轴方向的制动器21，以使液体药物医疗装置10在将注射器11拧到液体药物医疗装置10上的设定位置停止旋转(见图2)。
图3和图4显示了液体药物医疗装置10有一纵轴22，还包括有第一开口24的基本部件23，具有第二开口27和带有一根针杆29的第三开口28的流量调节部件26，及与基本部件23可拆卸连接的小瓶转接器31(构成了一个转接器)。第一开口24具有顺时针方向螺纹的母螺旋接头32，用于以顺时针方向螺丝连接注射器的顺时针公螺旋接头12。基本部件23有一个带环形凹槽34的腔33，可与流量调节部件26上呈环状的凸缘36卡接，由此，流量调节部件26围绕与纵轴22同轴的旋转轴37可旋转地支撑在腔33内。第一开口24通过垂直于旋转轴37的径向的孔38和腔33流体连接。基本部件23在其近端，具有一对侧面突出的构件39A和39B用以抵住制动器21，还有一对半转(half turn)螺纹41A和41B用于将小瓶转接器31螺纹连接在其上。
小瓶转接器31具有一延伸的杆42，它包括具有一近端43A的流体导管部件43，在小瓶转接器31连接在基本部件23上时与第二开口27流体连接，还包括尖的远端43B，用于在其正插入时，刺穿小瓶的橡皮塞子14，插到小瓶转接器31中，并稍微延伸进去一些，使得当把小瓶倒置时，小瓶内的几乎所有内容物都能够被抽吸入其中(见图5E)。杆42包括一个平行于流体导管部件43的孔44，并且大体上与其共同延伸，在将小瓶转接器31连接在主体部件23上时，用来将针杆29容纳在其中。杆42有一近端42A，其上有一对侧面突出的臂46A和46B，用于螺丝安装到一对半转螺纹41A和41B上，并用来抵靠在制动器21上。螺纹41A和41B与公螺旋接头12和母螺旋接头32的螺纹是方向相反的，使得将注射器11螺丝安装到基本部件23时，就将小瓶转接器31完全旋接到基本部件23上，并且转动包装壳18中的液体药物医疗装置10，直到基本部件的构件39A和小瓶转接器的臂46A紧靠住制动器21，以此将液体药物医疗装置10保持在其设定位置。近端42A具有槽47，用来接受流体调节部件26底面的向下悬垂的键48，籍此将小瓶转接器31耦合到流量调节部件26上，因此，手动旋转小瓶转接器31就相应地旋转了流量调节装置26。
在液体药物医疗装置10的设定位置，第二开口27通过与旋转轴37平行但非同轴的第一主导流管48，及与流量调节部件26的第一流量调节位置的孔38对齐的第一次导流管49，和第一开口24流体连接(见图4)。当小瓶转接器31通过半转旋转，沿着与纵轴22同方向的拆卸线准备从基本部件23上轴向拆卸分离时，第三开口28，通过与旋转轴37平行但非同轴的第二主导流管51，及与流量调节部件26的第二流量调节位置的孔38对齐的第二次导流管52，和第一开口24流体连接(见图5E)。
参考图5A-5F，现在描述液体药物医疗装置10的使用：
将剥离盖19从包装壳18上去掉，将一个预先充满的注射器11顺时针方向旋到母螺旋接头32上(见图5A)。液体药物医疗装置10开始时据其初时位置，可以在包装壳18内旋转，但当进入到设定位置时，就停止旋转。将液体药物医疗装置10从包装壳18内抽出，将小瓶13正向地插入小瓶转接器31中，使得流体导管部件43刺穿小瓶的橡皮塞子14(见图5B)。注射器中的内容物被注射到小瓶13中(见图5C)，将整个组件(包括液体药物医疗装置10，现在已经空了的注射器11，和小瓶13)进行晃动，使得小瓶中的干粉药物浓缩剂重新溶解。整个组件都倒置过来，抽动注射器吸取其中的重新溶解的液体药物(见图5D)。小瓶转接器31通过半转反时针方向转动，将流量调节部件26旋转到第二流量调节位置，以连接注射器11和注射针杆29，同时，将小瓶转接器31和用完的小瓶13从基本部件23上轴向拆卸下来(见图5E)。现在，液体药物医疗装置10已准备好通过还是干的针杆29将重新溶解的液体药物给病人用药(见图5F)。
图6显示了液体药物医疗装置61，其流量调节部件62配有雾化器63。
图7显示了液体药物医疗装置61，其流量调节部件67配有药物分配器口68。
图8显示了与注射器101联用的液体药物输送装置100，注射器101具有的注射器顶端102的远端103具有突出的缘104，用以阻止带有母螺旋接头的常规针头在其上滑动安装，具有橡皮塞子107并盛有干粉末状药物浓缩剂108的小瓶106同样也可以盛液体药物浓缩剂。液体药物输送装置100包括具有顶壁112的小瓶转接器111，弹性可变形的有裂缝的环绕结构113，用以卡接到小瓶106上，中空的穿刺部件114(见图9-11)用以刺穿小瓶的橡皮塞子107，及弹性管116与穿刺部件114流体连接，弹性管116的远端117用以紧密地安装在注射器的突出的缘104上，使得在注射器101和小瓶106之间能够流体连接。通常，弹性管116的长度L＝10-20mm，公称内径D1＝3-4mm，其内径很容易扩大到至少6mm以严密地安装到突出的缘的直径外D2＞D1，而不会发生撕开，劈裂等情况。弹性管116优选地由选自下列的材料形成：PVC，聚硅氧烷，橡胶等。
图9显示了包含有一小瓶转接器111的液体药物输送装置100，其转接器的向上的短接管118有一压接或者粘接于其上的小管116。图10显示了液体药物输送装置100，具有在小管116周围上方塑模(或又称为插入式塑模)而成的小瓶转接器111。图11显示了液体药物输送装置100，用两种材料注塑成型而制成，也就是，小瓶转接器111和小管116在同一个模具中制成。
图13显示了针头套移除装置200，用于与液体药物医疗装置201联用，其上的针头202配备有针头套203保护。液体药物医疗装置201可以是注射器的形式，MIXJECT流体调节装置可从麦迪麦珀医疗工程有限公司，让纳纳，以色列(Medimop Medical Projects Ltd，Ra’anana，Israel)购买，等等。液体药物医疗装置201包括一个公螺旋接头204，其具有环形末梢的末端底面206。注射针202包含一具有棱纹表面208的针座207，一个突出的边缘209，用以螺旋插入到公螺旋锁紧接头204上，及一根针杆211。针头套203包含一个突出的边缘212，设计用于卡接到棱纹表面208来套住针杆211，因此突出的缘212和末端底面206隔开大约1-2mm的间隙。针头套移除装置200被设计成正向地滑动针头套203约1-2mm的动程，足以从液体药物医疗装置201上除去针头套203，于是就安全且便捷地露出了针杆211。
图14显示了针头套移除装置200，它包括一个三腿基本部件214，一个压缩弹簧216，一个三腿的针头套释放部件217。基本部件214有一帽体218，帽体有顶壁219，外壁221，外壁有内槽222，内壁223和外壁221形成了管状的腔224，用于容纳压缩弹簧216。内壁223带有相互等距离围绕在其上的三个支持腿226，每个支持腿以弧角约60°分布。支持腿226终止于平的末端底面227，当将针头套移除装置200滑动安装到其上有防护针头202的液体药物医疗装置201时，用以抵靠在末端底面206上。
针头套释放部件217有一环形的顶部228，其上有用来止抵内槽222的保持翼片229，用来使针头套释放部件217在将其顶部228插接到管状的腔226中时，保持在基本部件214内。顶部228有一对反向的从侧面延伸出来的把手231，用来使压力施加到压缩弹簧16上，使得针头套释放部件217从向外的弹力偏移位置(见图15)到向内的手施压的位置(见图16)正向推进入基本部件214中。顶部228有三个等距离围绕于其上的针头套紧固腿232，使得在针头套移除装置213中，夹紧腿232置于相邻的支持腿226中间。针头套释放腿232类似支持腿226，也是以弧角约60°分布，因此，当针头套移除装置213滑动安装到液体药物医疗装置201的有防护的注射针202上时，针头套移除装置213就包围着针头套203。针头套紧固腿232终止于向内方向的针头套夹爪233，和弹簧向外偏移位置的末端底面227相平齐(见图14)，并且在施加压缩力正向将针头套释放部件217拉进基本部件213时，针头套的突出边缘212抵向端面206。
针头套移除装置200的使用如下：
使用者一手握住有防护的针头202的液体药物医疗装置201，另一只手抓住针头套移除装置200。使用者将针头套移除装置200滑动地安装到液体药物医疗装置201上，直到针头套夹爪233卡接到突出的边缘212上，同时末端底面227与末端底面206相邻(见图16)。使用者将其拇指放在顶壁219上，他的食指和中指抵住把手231的下侧，以使得他能施用压缩力将针头套释放部件217推进到基本部件214中。针头套释放部件217借助于它的针头套夹爪233抵住针头套的突出缘212，和它一起抽出针头套203，因此，就安全且便捷地露出针杆以准备注射。使用者将用过的液体药物医疗装置200和露在外面的针杆211丢弃到尖锐物容器中。
尽管上述用有限的几个实施例描述了本发明，本发明不限于此，在不脱离本发明精神和范围的各种变化，改进和其它实施方式都落入要求保护的本发明范围内。

Claims (16)

1.一种液体药物医疗装置，用于与生理溶液源及一种药物容器联用，用于液体药物的给药，该装置具有一纵轴，并包括：
(a)主体部分，具有与生理溶液源流体连接的第一开口；
(b)流量调节部件，围绕与纵轴同方向的旋转轴可转动地安装在所述的主体部分中，上，并具有第一主导流管和第二主导流管，其基本平行于但非同轴于所述的旋转轴，并且分别终止于第二开口，还有用于液体药物给药的第三开口；及
(c)手动可旋转的转接器，具有一流体导管部件，该部件具有一近端与所述的第二开口流体连接，还有一远端，在它连接到所述的转接器时延伸到药物容器内，该手动旋转的转接器耦联到所述的流量调节部件上，以使它在第一流量控制位置(用于连接所述第一开口与所述第二开口)和第二流量控制位置(用于连接所述第一开口与所述第三开口)之间转动。
2.如权利要求1所述的装置，其中所述的转接器沿着与纵轴同方向的拆卸线，可从所述的主体部分在所述第二流量调节位置上拆卸下来。
3.如权利要求2所述的装置，其中所述的第一开口具有螺纹用于通过螺纹从一个方向接受生理溶液源，所述的转接器可从相反方向通过螺纹从所述主体部分上拆卸下来。
4.如权利要求3所述的装置，其中所述的装置包装于无菌包装壳内，并且所述的基本部件有至少一个侧面突出的构件用以当将生理溶液源螺纹旋接到所述的第一开口时，抵靠住无菌包装内部的内纵轴方向的制动器，这时，所述的流量调节部件就被推进入所述的第一流量调节位置。
5.如权利要求1-4的任一项所述的装置，其中所述的转接器具有一个杆，它包括所述的流量调节部件和一个与其平行且共延伸的孔，用于容纳与所述的第三开口耦联的药物分配器。
6.如权利要求1-5的任一项所述的装置，其中所述的第三开口安装有一根针杆。
7.如权利要求1-5的任一项所述的装置，其中所述的第三开口安装有雾化器。
8.一种液体药物医疗装置，用于与注射器联用，该注射器有注射器顶端，带有有突出的缘的远端，及有橡皮塞的药物小瓶，该装置包含用于卡接到小瓶上的转接器，还包括一中空的穿刺部件，在将所述的转接器卡接到所述的小瓶上时，刺穿小瓶的橡皮塞，还包括与所述的穿刺部件流体连接的短的弹性小管，其有一远端能密封地拉伸到注射器的突出的缘的上方，以使在注射器和药物小瓶之间进行流体连接。
9.如权利要求8所述的装置，其中所述的小管的长度L＝10-20mm。
10.如权利要求8或9所述的装置，其中所述的小瓶转接器具有向上的短接管，所述的小管安装于所述的短接管上。
11.如权利要求8或9所述的装置，其中所述的小瓶转接器重叠模塑于所述的小管之上。
12.如权利要求8或9所述的装置，其中所述的装置由两种材料注塑制造而成。
13.一种针头套移除装置，用于与注射针有针头套保护的液体药物装置联用，注射针包括有突出边缘的针座，一针杆，该针头套移除装置包括：
(a)一基本部件，包括至少两个间隔分开的终止于末端底面的支持腿；及
(b)一针头套释放部件，包含一对反向的把手，及至少两个间隔分开的紧固腿插入到所述的至少两个间隔分开的支持腿之间，并且终止于针头套夹爪，以抵靠住注射针的突出的缘，使针头套从针头上滑动抽出，
所述的针头套释放部件沿着所述的基本部件，从初始的向外偏移的位置(其中所述的针头套夹爪基本平齐于所述的末端底面)，和收缩位置(其中所述的针头套夹爪相对于所述的末端底面向内排列)是可滑行移动的，
针头套移除装置被滑动安装到液体药物医疗装置，以在其内包住针头套，此时，针头套释放部件正向地推进到所述的收缩位置来抽出针头套，从而安全、便捷地露出了注射针杆。
14.如权利要求13所述的装置，其中当将针头套移除装置滑动地安装到液体药物医疗装置时，所述的至少两个间隔分开的支持腿和所述的至少两个间隔分开的紧固腿完全包围住针头套。
15.如权利要求14所述的装置，其中所述的基本部件包括三个支持腿，以约60°弧角分布，所述的针头套释放部件包括三个紧固腿，以约60°弧角分布。
16.如权利要求13-15的任一项所述的装置，其中所述的基本部件，在所述的缩进位置滑动地接受所述的针头套释放部件。
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CN101623525A (zh) 2010-01-13
EP1755520A2 (en) 2007-02-28
MXPA06012520A (es) 2007-03-21
IL161660A0 (en) 2004-09-27
WO2005105014A3 (en) 2005-12-01
EP1755520B1 (en) 2012-01-11
CA2743238C (en) 2013-07-30
US20080009789A1 (en) 2008-01-10
JP2010179128A (ja) 2010-08-19
US20100228220A1 (en) 2010-09-09
IL178711A0 (en) 2007-02-11
IL178711A (en) 2012-03-29
US8021325B2 (en) 2011-09-20
CA2563643C (en) 2012-10-30
EP2133059A2 (en) 2009-12-16
CN101623525B (zh) 2012-07-04
US8066688B2 (en) 2011-11-29
CA2563643A1 (en) 2005-11-10
CA2743238A1 (en) 2005-11-10
WO2005105014A2 (en) 2005-11-10
ATE540661T1 (de) 2012-01-15
EP2133059A3 (en) 2012-05-30
DK2133059T3 (en) 2018-02-05
JP2007534424A (ja) 2007-11-29
JP5161259B2 (ja) 2013-03-13
EP2133059B1 (en) 2017-11-08
JP4637173B2 (ja) 2011-02-23
CN100560046C (zh) 2009-11-18

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