CN1973812B - Method of powdering supercritical CO2 solid extract - Google Patents
Method of powdering supercritical CO2 solid extract Download PDFInfo
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- CN1973812B CN1973812B CN2006101232976A CN200610123297A CN1973812B CN 1973812 B CN1973812 B CN 1973812B CN 2006101232976 A CN2006101232976 A CN 2006101232976A CN 200610123297 A CN200610123297 A CN 200610123297A CN 1973812 B CN1973812 B CN 1973812B
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- carbon dioxide
- supercritical carbon
- dioxide extraction
- extraction thing
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Abstract
The present invention relates to medicine preparing technology, and is especially method of powdering supercritical CO2 extracted solid. For extract containing no crystal, the method includes adding fine silica gel powder via stirring, extruding the mixture through 100 mesh sieve and further mixing to obtain the extract powder. For extract containing crystal, the method includes dissolving the extract in solvent through stirring, adding fine silica gel powder via stirring, extruding the mixture through 100 mesh sieve, volatilizing solvent at 50 deg.c and further mixing to obtain the extract powder. The powdered extract thus obtained has high flowability, homogeneous content, less degeneration, easy mixing with other material, and other advantages.
Description
Technical field
The present invention relates to a kind of drug preparation technique, especially with the method for supercritical carbon dioxide extraction thing solid powdering.
Background technology
At present, supercritical carbon dioxide extraction method is widely used in Chinese medicine and natural drug extraction.Because the supercritical carbon dioxide extraction owner will contain low-polarity component, one or more mixed styles with fluid oil, semisolid oils and fats, solid state crystallization under the room temperature exist, extract is being made in the solid dosage forms processes such as tablet, capsule, granule, pill, have following problem: (1) extract contains certain moisture, and is apt to deteriorate in storage process; (2) method that sprays into of extract by adopting routine or the method for being blended into add fashionable being difficult to and the unclassified stores mix homogeneously.The present inventor has found a kind of method with supercritical carbon dioxide extraction thing solid powdering through years of researches, the pressed powder good fluidity of making, and uniform content, not perishable, store easily, transport.Particularly in the solid dosage form formulation process, be easy to adopt be blended into method and unclassified stores mix homogeneously.
Summary of the invention
The object of the present invention is to provide a kind of method with supercritical carbon dioxide extraction thing solid powdering, extract is added a small amount of adjuvant make good fluidity, not perishable, store easily, the solid state powder of convenient transportation, particularly in making the solid preparation process, make it easily and the unclassified stores uniform mixing.
The object of the present invention is achieved like this: a kind of method with supercritical carbon dioxide extraction thing solid powdering, it is for the supercritical carbon dioxide extraction thing that does not contain solid crystal, directly add micropowder silica gel, stir, pushed 100 orders with upper screen cloth, mix homogeneously promptly gets the extract pressed powder.For the supercritical carbon dioxide extraction thing that contains solid crystal, then add an amount of solvent earlier, stirring and dissolving adds micropowder silica gel again, stirs, and pushes 100 orders with upper screen cloth, and low temperature is flung to solvent below 50 ℃, and mix homogeneously promptly gets the extract pressed powder.
In above-mentioned a kind of method with supercritical carbon dioxide extraction thing solid powdering, for the supercritical carbon dioxide extraction thing that does not contain solid crystal, the adding weight of micropowder silica gel is for being no less than 0.3 times of extract weight;
In above-mentioned a kind of method with supercritical carbon dioxide extraction thing solid powdering, for the supercritical carbon dioxide extraction thing that contains solid crystal, the solvent that adds comprises: ethyl acetate, ether and petroleum ether, solvent adds 0.5 times of amount that weight is no less than extract weight, and the adding weight of micropowder silica gel is for being no less than 0.5 times of extract weight.
Method of the present invention compared with prior art has following advantage: 1. after extract is made pressed powder, and good fluidity, uniform content, not perishable, store easily, transport.2. in the solid dosage form formulation process, easily and the unclassified stores mix homogeneously.
The specific embodiment
Embodiment 1
Get 1 kilogram Radix Angelicae Sinensis supercritical carbon dioxide extraction thing (liquid state), add 0.4 kilogram of micropowder silica gel, mix, pushed 100 orders with upper screen cloth, mix homogeneously promptly gets Radix Angelicae Sinensis supercritical carbon dioxide extraction thing pressed powder.
Embodiment 2
Get 1 kilogram Flos Jasmini Sambac supercritical carbon dioxide extraction thing (semisolid oils and fats), add 0.5 kilogram of micropowder silica gel, mix, pushed 100 orders with upper screen cloth, mix homogeneously promptly gets Flos Jasmini Sambac supercritical carbon dioxide extraction thing pressed powder.
Embodiment 3
Get 1 kilogram Cortex Magnoliae Officinalis supercritical carbon dioxide extraction thing (containing crystallization in the semisolid oils and fats), add 0.5 kilogram of ethyl acetate, stirring and dissolving, add 0.5 kilogram of micropowder silica gel again, mix, pushed 100 orders with upper screen cloth, mix homogeneously, fling to ethyl acetate under 40 ℃, promptly get Cortex Magnoliae Officinalis supercritical carbon dioxide extraction thing pressed powder.
Embodiment 4
Get 1 kilogram Fructus Schisandrae Chinensis supercritical carbon dioxide extraction thing (containing crystallization in the fluid oil), add 0.5 kilogram of ethyl acetate, stirring and dissolving, add 0.5 kilogram of micropowder silica gel again, mix, pushed 100 orders with upper screen cloth, mix homogeneously, fling to ethyl acetate under 40 ℃, promptly get Fructus Schisandrae Chinensis supercritical carbon dioxide extraction thing pressed powder.
Claims (2)
1. method with supercritical carbon dioxide extraction thing solid powdering, this supercritical carbon dioxide extraction thing is a Cortex Magnoliae Officinalis, it is characterized in that for containing crystalline semisolid oil smectic attitude:
Add an amount of solvent earlier, stirring and dissolving adds micropowder silica gel again, stirs, and pushes 100 orders with upper screen cloth, and low temperature below 40 ℃ is waved most solvent, and mix homogeneously promptly gets Cortex Magnoliae Officinalis supercritical carbon dioxide extraction thing pressed powder;
Wherein, the solvent of adding is: ethyl acetate, solvent add weight and are no less than 0.5 times of extract weight, and the adding weight of micropowder silica gel is to be no less than 0.5 times of extract weight.
2. method with supercritical carbon dioxide extraction thing solid powdering, this supercritical carbon dioxide extraction thing is a Fructus Schisandrae Chinensis, it is characterized in that for containing crystalline fluid oil state:
Add an amount of solvent earlier, stirring and dissolving adds micropowder silica gel again, stirs, and pushes 100 orders with upper screen cloth, and low temperature below 40 ℃ is waved most solvent, and mix homogeneously promptly gets Fructus Schisandrae Chinensis supercritical carbon dioxide extraction thing pressed powder;
Wherein, the solvent of adding is: ethyl acetate, solvent add weight and are no less than 0.5 times of extract weight, and the adding weight of micropowder silica gel is to be no less than 0.5 times of extract weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101232976A CN1973812B (en) | 2006-11-03 | 2006-11-03 | Method of powdering supercritical CO2 solid extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101232976A CN1973812B (en) | 2006-11-03 | 2006-11-03 | Method of powdering supercritical CO2 solid extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1973812A CN1973812A (en) | 2007-06-06 |
| CN1973812B true CN1973812B (en) | 2010-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006101232976A Active CN1973812B (en) | 2006-11-03 | 2006-11-03 | Method of powdering supercritical CO2 solid extract |
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| CN (1) | CN1973812B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870619A (en) * | 2020-09-09 | 2020-11-03 | 广东一方制药有限公司 | Radix angelicae pubescentis traditional Chinese medicine formula granules and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107696A (en) * | 1994-12-30 | 1995-09-06 | 李志宏 | Preparing technology for instant granules of single Chinese-medicinal herb |
| US5795594A (en) * | 1993-07-01 | 1998-08-18 | Glaxo Group Limited | Salmeterol xinafoate with controlled particle size |
| CN1397632A (en) * | 2001-07-19 | 2003-02-19 | 刘玉 | Process for extracting from flax seeds by supercritical CO2 |
| CN1778807A (en) * | 2004-11-26 | 2006-05-31 | 周亚伟 | Production of Rhizoma Picrorhizae glucoside II monomer and its drug form for treating hepatitis B |
-
2006
- 2006-11-03 CN CN2006101232976A patent/CN1973812B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795594A (en) * | 1993-07-01 | 1998-08-18 | Glaxo Group Limited | Salmeterol xinafoate with controlled particle size |
| CN1107696A (en) * | 1994-12-30 | 1995-09-06 | 李志宏 | Preparing technology for instant granules of single Chinese-medicinal herb |
| CN1397632A (en) * | 2001-07-19 | 2003-02-19 | 刘玉 | Process for extracting from flax seeds by supercritical CO2 |
| CN1778807A (en) * | 2004-11-26 | 2006-05-31 | 周亚伟 | Production of Rhizoma Picrorhizae glucoside II monomer and its drug form for treating hepatitis B |
Non-Patent Citations (4)
| Title |
|---|
| 刘兴文等.中药颗粒剂的工艺进展.时珍国药研究第8卷 第4期.1997,第8卷(第4期),378-379. |
| 刘兴文等.中药颗粒剂的工艺进展.时珍国药研究第8卷 第4期.1997,第8卷(第4期),378-379. * |
| 孙维广等.中药颗粒剂的发展与制备工艺的改进.中药研究与信息第3卷 第10期.2001,第3卷(第10期),21-23. |
| 孙维广等.中药颗粒剂的发展与制备工艺的改进.中药研究与信息第3卷 第10期.2001,第3卷(第10期),21-23. * |
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| CN1973812A (en) | 2007-06-06 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Guangdong E.Fong Pharmaceutical Co., Ltd. Assignor: Tan Dengping Contract record no.: 2011440000050 Denomination of invention: Method of powdering supercritical CO2 solid extract Granted publication date: 20101208 License type: Exclusive License Open date: 20070606 Record date: 20110211 |
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| ASS | Succession or assignment of patent right |
Owner name: GUANGDONG YIFANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: TAN DENGPING Effective date: 20111201 |
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Effective date of registration: 20111201 Address after: 528244, Guangdong Province, Foshan Province Nanhai Lishui banner Town Industrial Development Zone Guangdong one side Pharmaceutical Co., Ltd. Patentee after: Guangdong E.Fong Pharmaceutical Co., Ltd. Address before: 528244 Guangdong Province Nanhai District of Foshan City Industrial Development Zone Guangdong Qifeng town Party Pharmaceutical Co. Ltd. Patentee before: Tan Dengping |