CN1980948B - 治疗由增强磷酸化介导的疾病和病况 - Google Patents
治疗由增强磷酸化介导的疾病和病况 Download PDFInfo
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- CN1980948B CN1980948B CN2003801093164A CN200380109316A CN1980948B CN 1980948 B CN1980948 B CN 1980948B CN 2003801093164 A CN2003801093164 A CN 2003801093164A CN 200380109316 A CN200380109316 A CN 200380109316A CN 1980948 B CN1980948 B CN 1980948B
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- phosvitin
- fragment
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- dephosphorylation
- cancer
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K38/38—Albumins
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Abstract
Description
组分 | 浓度 |
甘露醇 | 60mmol |
乳糖酸 | 80mmol |
谷氨酸 | 20mmol |
组胺酸 | 30mmol |
氯化钙 | 0.25mmol |
氯化钾 | 15mmol |
氯化镁 | 13mmol |
氢氧化钠 | 100mmol |
还原的谷胱苷肽 | 3mmol |
注射用水 | 加至1升 |
样品 | IL-8(pg/ml) | IL-8释放的抑制百分比 |
阴性对照(无PMA,无伊屋诺霉素,无BSA,无卵黄高磷蛋白) | 0.0 | --- |
阳性对照(PMA和伊屋诺霉素;无BSA或卵黄高磷蛋白) | 1119.2 | --- |
0.1mg/ml鸡蛋黄卵黄高磷蛋白(脱磷酸化的)和PMA和伊屋诺霉素 | 1024.7 | 6.4% |
0.5mg/ml鸡蛋黄卵黄高磷蛋白(脱磷酸化的)和PMA和伊屋诺霉素 | 830.4 | 25.8% |
1.0mg/ml鸡蛋黄卵黄高磷蛋白(脱磷酸化的)和PMA和伊屋诺霉素 | 686.9 | 38.6% |
1.0mg/ml Sigma卵黄高磷蛋白(未处理的)和PMA和伊屋诺霉素 | 1153.6 | 0% |
1.0mg/ml Sigma BSA(未处理的)和PMA和伊屋诺霉素 | 1048.1 | 6.3% |
Claims (56)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42992402P | 2002-11-27 | 2002-11-27 | |
US60/429,924 | 2002-11-27 | ||
PCT/US2003/037901 WO2004050023A2 (en) | 2002-11-27 | 2003-11-25 | Treatment of diseases and conditions mediated by increased phosphorylation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110158436XA Division CN102266272B (zh) | 2002-11-27 | 2003-11-25 | 一种个人护理组合物及其产品 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1980948A CN1980948A (zh) | 2007-06-13 |
CN1980948B true CN1980948B (zh) | 2011-08-10 |
Family
ID=32469391
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110158436XA Expired - Fee Related CN102266272B (zh) | 2002-11-27 | 2003-11-25 | 一种个人护理组合物及其产品 |
CN2003801093164A Expired - Fee Related CN1980948B (zh) | 2002-11-27 | 2003-11-25 | 治疗由增强磷酸化介导的疾病和病况 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110158436XA Expired - Fee Related CN102266272B (zh) | 2002-11-27 | 2003-11-25 | 一种个人护理组合物及其产品 |
Country Status (13)
Country | Link |
---|---|
US (3) | US7982008B2 (zh) |
EP (1) | EP1572115B1 (zh) |
JP (1) | JP5204947B2 (zh) |
KR (1) | KR101188292B1 (zh) |
CN (2) | CN102266272B (zh) |
AU (3) | AU2003299568B2 (zh) |
BR (1) | BR0315942A (zh) |
CA (1) | CA2507051C (zh) |
HK (2) | HK1083062A1 (zh) |
IL (4) | IL168775A (zh) |
NZ (2) | NZ540767A (zh) |
WO (1) | WO2004050023A2 (zh) |
ZA (1) | ZA200505113B (zh) |
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WO2004050023A2 (en) | 2002-11-27 | 2004-06-17 | Dmi Biosciences, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
EP2112920B1 (en) | 2003-06-26 | 2018-07-25 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
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KR102203626B1 (ko) * | 2018-03-22 | 2021-01-15 | 건국대학교 산학협력단 | 포스비틴 및 리소자임을 포함하는 면역증강용 약학적 조성물 및 건강기능식품 |
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US8507651B2 (en) | 2013-08-13 |
JP5204947B2 (ja) | 2013-06-05 |
IL205850A (en) | 2016-04-21 |
EP1572115B1 (en) | 2015-01-21 |
US7982008B2 (en) | 2011-07-19 |
AU2003299568A1 (en) | 2004-06-23 |
CA2507051A1 (en) | 2004-06-17 |
CN102266272B (zh) | 2012-12-26 |
AU2010235897A1 (en) | 2010-11-11 |
US20040220087A1 (en) | 2004-11-04 |
NZ574520A (en) | 2011-02-25 |
IL205852A (en) | 2016-08-31 |
CN102266272A (zh) | 2011-12-07 |
ZA200505113B (en) | 2006-12-27 |
AU2013205973A1 (en) | 2013-06-06 |
EP1572115A2 (en) | 2005-09-14 |
BR0315942A (pt) | 2005-10-04 |
KR20050094398A (ko) | 2005-09-27 |
IL205851A (en) | 2015-06-30 |
CA2507051C (en) | 2015-04-07 |
US20110237492A1 (en) | 2011-09-29 |
US20110230417A1 (en) | 2011-09-22 |
WO2004050023A2 (en) | 2004-06-17 |
WO2004050023A3 (en) | 2007-02-15 |
EP1572115A4 (en) | 2009-11-25 |
HK1083062A1 (zh) | 2006-06-23 |
HK1164694A1 (en) | 2012-09-28 |
CN1980948A (zh) | 2007-06-13 |
AU2003299568B2 (en) | 2010-07-22 |
KR101188292B1 (ko) | 2012-10-09 |
IL168775A (en) | 2015-02-26 |
NZ540767A (en) | 2009-03-31 |
JP2007521223A (ja) | 2007-08-02 |
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