CN202105047U - 小外形经导管的心瓣膜 - Google Patents

小外形经导管的心瓣膜 Download PDF

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CN202105047U
CN202105047U CN2009901003692U CN200990100369U CN202105047U CN 202105047 U CN202105047 U CN 202105047U CN 2009901003692 U CN2009901003692 U CN 2009901003692U CN 200990100369 U CN200990100369 U CN 200990100369U CN 202105047 U CN202105047 U CN 202105047U
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framework
pole
valve
artificial valve
lobule
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I·哈里顿
N·本尼楚
Y·尼赞
B·费尔森
D·源-天-纳
R·康纳
S·源
T·莱威
I·派利德
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Abstract

根据一个实施例，一种可植入的人工瓣膜(10)包括框架(12)、小叶结构(14)和裙部部件(16)。该框架可以具有由多个圆周支杆(22，24)相互连接的多个轴向支杆(20)。该小叶结构包括多个小叶(例如，布置三个小叶以形成三尖瓣)。该小叶结构具有固定于该框架的扇贝形下边缘部分。该裙部部件可以设置在小叶结构和框架之间。

Description

小外形经导管的心瓣膜
技术领域
本实用新型涉及可植入的装置，更具体地说，涉及用于植入诸如自体心瓣膜环的身体导管中的瓣膜假体。 
背景技术
人的心脏遭受各种瓣膜疾病。这些瓣膜疾病可以导致心脏重大功能障碍并且最终需要用人工瓣膜替换自体瓣膜。有许多种已知的人工瓣膜和将这些人工瓣膜植入人体中的许多种已知的方法。 
各种外科技术可以用于修复患病的或损坏的瓣膜。在瓣膜置换手术中，损坏的小叶被切去并且环被修整成接纳替换瓣膜。由于主动脉狭窄和其他心瓣膜疾病，每年有成千上万的病人进行外科手术，其中有缺陷的自体心脏瓣膜用人工瓣膜(生物假体瓣膜或机械瓣膜)替换。另一种用于治疗有缺陷的瓣膜的不太剧烈的方法是通过修复或重新构造，这种方法通常用于极小的钙化的瓣膜。外科治疗的问题是由于与外科修复相关的高发病率和死亡率对这些慢性病人产生重大的损害。 
当置换瓣膜时，人造瓣膜的外科植入通常需要开胸外科手术，在此期间心脏停止并且病人被放置在心肺旁路(所谓的“心肺机”)上。在一种通常的外科手术过程中，患病的自体瓣膜小叶被切去并且人造瓣膜被缝合在瓣膜环的周围组织上。由于与手术过程以及体外血液循环的护理期间相关的创伤，一些病人不能在外科手术过程中活下来或者在手术后短时间死亡。众所周知，病人的风险随着体外循环所需要的时间量而增加。由于这些风险，相当数目的瓣膜有缺陷的病人由于其身体状况太虚弱不能经受外科手术过程而被认为是不宜手术的。一些估计认为，50％以上的80岁以上患有主动脉狭窄的受治疗者不能进行主动脉瓣膜置换手术。 
由于与常规的开放心脏外科手术相关的缺点，经皮的和微创式外科方法受到高度关注。在一种技术中，人工瓣膜被配置为在很小的侵 入手术过程中通过导管插入的方式被植入。例如，美国专利第5,411,522和6,730,118号公开了一种可收缩的经导管的心瓣膜，该心瓣膜能够以在导管上的压缩状态而被经皮地引入并且通过气囊膨胀或者通过利用自扩展框架或支架在希望的位置扩张，这些专利作为参考合并到本文。 
经导管的心瓣膜的一个重要设计参数是折叠的或卷曲外形的直径。卷曲外形的直径是很重要的，因为它直接影响外科医生将瓣膜推进通过股动脉或静脉的能力。更具体地说，较小的外形能够用于治疗更多的病人，且具有增加的安全性。 
发明内容
本公开涉及与诸如心瓣膜的人造瓣膜相关的新的、非显而易见的方法和设备。 
在一个代表性的实施例中，可植入的人工瓣膜包括径向可收缩的并且可扩张的框架或支架，以及包括多个小叶的小叶结构。该小叶结构具有位于该框架的里面并且固定于该框架的扇贝形下边缘部分。该瓣膜还可以包括环状的裙部部件，该裙部部件能够设置在框架和小叶结构之间，使得扇贝形下边缘部分能够连接于裙部部件的内表面。每个小叶可以具有上边缘、弯曲的下边缘和在上边缘和下边缘的相应端之间延伸的两个侧面片状物，其中每个侧面片状物固定于另一个小叶的相邻的侧面片状物，以形成小叶结构的接缝。每个接缝可以连接于其中一个接缝连接柱，并且加强杆可以设置为紧靠(against)每个侧面片状物，用于加强接缝和接缝连接柱之间的连接。 
框架可以包括多个成角度地间隔开的轴向支杆，该轴向支杆由多行圆周支杆相互连接。希望每行圆周支杆包括被布置为围绕框架的圆周以Z字形(zig-zag)或锯齿形图形延伸的支杆。 
在一些实施例中，至少一行(优选所有行)圆周支杆包括在两个轴向支杆之间延伸的圆周支杆对。该对支杆的每个支杆的一端连接于相应的轴向支杆，而另一端通过隆起部分相互连接于同一对的另一个支杆的相邻端，使得在支杆的相邻端之间存在间隙。希望每对支杆之间的角度在90度和110度之间，其中大约100度是特殊的例子。希望框架用镍钴基的合金制造，例如镍钴铬钼合金(例如，MP35NTM)。 
在另一个代表性的实施例中，可植入的人工瓣膜包括径向可收缩并且可扩张的环形框架和由该框架支撑的小叶结构。该框架可以包括在框架中限定多个开口网眼(cell)的多个相互连接的支杆。该瓣膜还包括设置在框架的至少一部分上并覆盖框架的至少一部分网眼的环形外罩部件。希望该外罩部件包括诸如硅的弹性体，当瓣膜从卷曲状态扩张到扩张的状态时该外罩部件能够扩张并拉伸。 
外罩部件可以是围绕框架的至少一部分的由硅制成的薄套筒。可替换地，外罩部件可以通过将框架的至少一部分浸渍在液态形式的硅或其他合适的弹性体中形成。 
在另一个代表性的实施例中，公开一种用于卷曲具有框架和由框架支撑的小叶的可植入人工瓣膜的方法。该方法包括将瓣膜放置在卷曲装置的卷曲小孔中，使得可压缩的材料设置在该卷曲装置的卷曲爪和瓣膜的框架之间。用卷曲爪将压力施加在可压缩的材料和瓣膜上，以径向卷曲该瓣膜成较小的外形，并且将可压缩材料向瓣膜压紧以使得可压缩材料延伸到框架的开口网眼中，并且将小叶推离框架的内侧。 
根据本实用新型，提供一种可植入的人工瓣膜，其包括：径向可收缩并且可扩张的环形框架，该框架具有三个接缝连接柱和在所述接缝连接柱之间延伸的三行圆周支杆，第一行圆周支杆限定所述框架的流入端，而与所述第一行间隔开的第二圆周支杆和第三行圆周支杆邻近所述框架的流出端，所述第一行通过多个轴向支杆连接于所述第二行和所述第三行，每行圆周支杆包括成角度的支杆，该成角度的支杆布置成Z字形图形并且通过大致U形的隆起结构相互连接以便改进可收缩性；包括由心包组织形成的三个小叶的小叶结构，每个小叶具有上边缘、弯曲的下边缘和两个侧面片状物，其中每个侧面片状物固定于另一个小叶的相邻的侧面片状物，以形成所述小叶结构的接缝，每个接缝连接于所述接缝连接柱中的一个；设置在所述环形框架和所述小叶结构之间的环形的裙部部件，每个小叶的所述弯曲的下边缘沿着扇贝形路线缝合于所述裙部部件的内表面；以及邻近每个接缝连接柱设置的成对加强杆，每个加强杆包括多个孔，其中每个侧面片状物围绕一个加强杆延伸，并且每个加强杆缝合于一个接缝连接柱，用于加强所述小叶结构和所述接缝连接柱之间的连接。 
根据本实用新型的另一个实施例，所述第一行和所述第二行圆周支杆具有平行的Z字形图形。 
本实用新型的前述和其他特征和优点从下面参考附图进行的详细描述中将变得更加明白。 
附图说明
图1是人工心瓣膜的代表性实施例的透视图。 
图2是图1的人工瓣膜的另一个透视图。 
图3是图1的人工瓣膜的另一个透视图。 
图4是图3所示的瓣膜的一部分的放大图。 
图5是图1的人工瓣膜的底视透视图，示出该瓣膜的里面。 
图6是图1的人工瓣膜的顶视平面图。 
图6A是图1的瓣膜的放大的局部顶视图，示出相对于框架的接缝连接柱的加强杆的设置。 
图7是图1的人工瓣膜的框架的透视图。 
图8是能够用在图1的人工瓣膜中的框架的可替换实施例的透视图。 
图9是图7所示的框架的120度分割部分的展开图。 
图10是图8所示的框架的120度分割部分的展开图。 
图11是加强杆的正视图，该加强杆能够用来加强将瓣膜小叶连接于诸如图1所示的人工瓣膜中的框架的连接。 
图12是图11的加强杆和能够用于覆盖该杆的PET套筒的透视图。 
图13是图1所示瓣膜的小叶的展开图。 
图14是小叶的相对侧的展开图，示出靠近小叶的底边缘而固定的加强带。 
图15是图1的瓣膜小叶结构在连接于框架之前的顶视平面图。 
图16是在图1的瓣膜中所用的裙部的展开图。 
图17是图16所示的裙部在相对端部互相连接以形成环形形状之后的侧视图。 
图18是连接于裙部以便形成小叶组件的小叶结构的底视透视图。 
图19是气囊导管和卷曲在该气囊导管的气囊上的人工瓣膜的侧视 图。 
图20是卷曲装置的正视图，示出设置在卷曲装置的卷曲小孔中的人工瓣膜，其中保护套筒设置在瓣膜和卷曲爪之间。 
图21是示出卷曲爪被向内施力以压紧瓣膜和保护套筒之后的卷曲装置的正视图。 
图22是从卷曲装置取出之后的瓣膜和保护套筒的侧视图。 
图23是卷曲在气囊导管的气囊上没有保护套筒的人工瓣膜的侧视图。 
图24是以图20-21的所示方式利用保护套筒卷曲在气囊导管的气囊上的人工瓣膜的侧视图。 
图25是用于人工瓣膜的框架侧视图，该框架具有设置在该框架外面的硅裙部或套筒。 
图26是用于人工瓣膜的框架的侧视图，该框架具有覆盖该框架里面和外面的硅密封层。 
图27是包括具有硅密封层的框架的人工瓣膜的透视图。 
图28是图27的瓣膜被卷曲成较小直径之后的透视图。 
图29是图27的瓣膜被气囊导管扩张之后的侧视图。 
图30A-30C是示出在相应的硅测试带上进行的相应的单轴测试的结果的曲线图。 
图31A-31F是示出在相应的硅测试带上进行的相应的单轴测试的结果的曲线图，该硅测试带具有故意引进的裂纹。 
具体实施方式
图1和图2示出根据一个实施例的可植入人工心瓣膜10。所示的实施例中的瓣膜10通常包括框架或支架12、由该框架支撑的小叶结构14以及固定于小叶结构的外表面的裙部16。瓣膜10通常被植入自体主动脉瓣膜的环中，但是也能够适于植入心脏的其他自体瓣膜或身体的各种其他管道或小孔中。瓣膜10具有“下”端80和“上”端82。在本申请的上下文中，术语“下”和“上”与术语“流入”和“流出”可分别互换使用。因此，例如，瓣膜的下端80是其流入端，瓣膜的上端82是其流出端。 
瓣膜10和框架12被配置为快速地收缩成收缩的或卷曲的状态，用以在输送导管上引进身体中，并且被配置为可快速地扩张成扩张的状态用以将瓣膜植入身体中希望的部位(例如自体主动脉瓣膜)。框架12可以用使瓣膜能够卷曲成较小的外形的可塑性扩张的材料制造，以便通过使用诸如气囊导管的气囊的扩张装置输送并扩张瓣膜。能够用来形成框架的示范性的可塑性扩张的材料在下面描述。可替换地，瓣膜10可以是所谓的自扩张瓣膜，其中框架用诸如镍钛诺(Nitinol)的自扩张材料制造。自扩张瓣膜能够卷曲成较小的外形并且用诸如覆盖瓣膜的护套的约束装置保持在卷曲的状态。当瓣膜位于或接近目标部位处时，约束装置被去掉以使瓣膜能够自扩张到其扩张的功能尺寸。 
也参考图7(为了示意的目的，图7只示出框架)，框架12是环形的支架状结构，具有多个成角度地间隔开的、竖直延伸的接缝连接柱或支杆18。柱18经由圆周延伸的支杆20的下行36a和分别圆周延伸的支杆22和24的分别的第一和第二上行36b、36c相互连接。希望每行中的支杆设置成如图所示的沿着框架的圆周方向延伸的Z字形，或大体的锯齿状图形。同一行中相邻的支杆可以彼此相互连接，如图1和图5所示，以形成角度A，希望该角度A在大约90和110度之间，其中大约100度是特殊的例子。对90和110度之间的角度A的选择使框架12在扩张时的径向强度最优化，且仍然允许框架12以下面描述的方式均匀地卷曲。 
在所示的实施例中，在同一行中相邻的圆周支杆对通过相应的大体U形形状的隆起结构或隆起部分26彼此连接。每个隆起结构26包括在支杆的相邻端之间延伸并连接支杆的相邻端的水平部分，因此在相邻端之间形成间隙28，并且该隆起结构在偏离该支杆的正常交点的位置连接该相邻端。在框架12以下面所述的方式卷曲和扩张期间，隆起结构26明显减少框架12上在支杆20、22、24的位置处的残余应力。连接在共用隆起结构26处的每对支杆22与上面一行中的相邻的一对支杆24形成网眼。每个网眼在节点32能够连接于相邻的网眼。每个节点32通过相应的竖直(轴向)支杆30能够与下一行的支杆相互连接，该竖直(轴向)支杆30连接于相应的节点32和下面一行支杆20上的位置并在其之间延伸，在该位置两个支杆在其与隆起结构26相对 的端部被连接。 
在一些实施例中，下支杆20具有大于上支杆22、24的厚度或直径。在一个实施例中，例如，下支杆20具有大约0.42mm的厚度T(图9)，而上支杆22、24具有大约0.38mm的厚度T。由于在所示的结构中仅有一行下支杆20和两行上支杆22、24，所以下支杆20相对于上支杆22、24的增大在框架的下部区域增加框架的径向强度并且允许框架更加均匀的扩张。 
图9示出图7所示的框架12的120度分割部分的展开图，该分割部分包括在两个连接柱18之间延伸的框架的部分。如图所示，每个框架分割部分具有支杆的三个列34和三个行36a、36b、36c。每个列34由在两个轴向延伸的支杆18、30之间延伸的邻接的支杆对20、22、24形成。希望框架12包括三个120度分割部分，其中每个分割部分由两个连接柱18定边界。因此，在所示实施例中每个框架12包括总共包括9个列。 
希望列和行的数目最小化，以减小瓣膜的总的卷曲外形，如下面进一步讨论的。图7和图9的设置通常用于直径小于大约29mm的瓣膜，并且最适合于直径为约20-26mm的瓣膜。在包括框架12的瓣膜的工作例子中，20mm的瓣膜能够卷曲成约17Fr的直径，23mm的瓣膜能够卷曲成约18Fr的直径，而26mm的瓣膜能够卷曲成约19Fr的直径。对于约29mm或更大直径的瓣膜，可以希望增加支杆另外的行和列。 
例如，图8和图10示出可替换框架40，该框架40类似于框架12，除了框架40具有四个支杆行(最下的、支杆42的第一行52a，支杆44的第二行52b、支杆46的第三行52c和支杆48的最上行52d)而不是三个支杆行，以及用于每个120度的框架分割部分有四个支杆列50而不是三个支杆列之外。图10示出图8所示的框架40的120度分割部分的展开图。在所示实施例中框架40包括三个这种120度的分割部分，提供用于框架的总共12个支杆列50。 
希望第三行的支杆46与第四行的支杆48面向相反的方向(即顶点或隆起部分面向相反的方向)，以在瓣膜的卷曲和扩张期间帮助避免框架的竖直柱的弯曲。可以设置第二行支杆44以便如图所示与第一 行的支杆42面向相同的方向(即，顶点或隆起部分面向相同的方向)。可替换地，第二行支杆44可以与第一行的支杆42面向相反的方向，以便分别像由第三和第四行的支杆46、48形成的网眼一样，形成方形网眼。框架40也可以包括轴向延伸的支杆54，支杆54连接于每个支杆42、44、46、48的端部并在其间延伸，支杆42、44、46、48在不连接于连接柱18的列50中对齐。正如上面所指出的，框架40最适合于直径为29mm或更大的瓣膜(当扩张到其功能尺寸时)。在包括框架40的瓣膜的工作例子中，29mm的瓣膜能够卷曲成约21Fr的直径。 
能够用于形成框架的合适的可塑性扩张的材料包括但不限于，不锈钢、镍基合金(例如，镍钴铬合金)、聚合物或其组合。在具体的实施例中，框架20用诸如MP35NTM(SPS Technologies的商标名称)的镍钴铬钼合金制造，MP35NTM相当于UNS R30035(被ASTM F562-02涵盖)。MP35NTM/UNS R30035按照重量包括35％的镍、35％的钴、20％的铬和10％的钼。已经发现，利用MP35N形成框架20提供优于不锈钢的高级结构效果。具体说，当MP35N用作框架材料时，实现相同的或更好的径向性能和抗压扁力性、抗疲劳性和耐腐蚀性需要较少的材料。而且，由于需要较少的材料，框架的卷曲外形可以减小，因而，提供用于经皮输送到身体中的治疗部位的较小外形瓣膜组件。 
再参考图1，例如，裙部16可以用聚对苯二甲酸乙二醇酯(PET)带状物(ribbon)形成。裙部的厚度可以变化，但是希望小于6密耳(mil)，而且希望小于4密耳，甚至更希望小于约2密耳。裙部16可以通过Lenzing缝合线56固定于框架12的里面，如图1所示。小叶结构14可以通过下面讨论的薄PET加强带68(或套筒)连接于裙部，薄PET加强带68能够固定缝合并且保护小叶结构的周围组织不受撕裂。如图所示，小叶结构14可以夹在裙部16和薄PET带68之间。将PET带和小叶结构14固定于裙部16的缝合线58可以是任何合适的缝合线，例如Ethibone缝合线。正如在下面更加详细地描述的，希望缝合线58沿着小叶结构14的底边缘的曲线就位。小叶结构14可以用本领域已知的公开在美国专利6,730,118中的牛心包组织、可生物相容的合成材料或各种其他合适的天然或合成材料，该美国专利结合于此供参考。 
小叶结构14可以包括三个小叶60，小叶60能够设置成以三尖瓣 结构收缩，如最佳示出在图2和图6。希望小叶结构14的下边缘具有波浪形的、弯曲的扇贝形形状(图1所示的缝合线路58沿着小叶结构的扇贝形形状就位)。通过用这种扇贝形的几何形状形成小叶，小叶上的应力减小，这进而又改善瓣膜的耐久性。而且，借助于扇贝形的形状，能够消除或至少最小化在每个小叶的凸部(belly)(每个小叶的中间区域)处的折叠和皱褶(ripple)，这些折叠和皱褶能够引起这些区域中的早期钙化。该扇贝形几何形状还减少用于形成小叶结构的组织材料的量，因而允许在瓣膜的流入端较小的更加均匀的卷曲外形。 
小叶60能够在其相邻的边被相互固定以形成小叶结构的接缝84(小叶合在一起的边缘)。可以用合适技术和机构将小叶结构14固定于框架12。例如，如图6最好地所示，希望小叶结构的接缝84与支撑柱18对齐并且利用缝合线将小叶结构的接缝84固定至支撑柱18。小叶连接于柱18的连接点可以用杆62(图11)加强，希望该杆用相对刚性的(与小叶相比)材料制造，例如不锈钢。 
图13示出单个的小叶60，小叶60具有弯曲的下边缘64和在小叶上边缘和下边缘之间延伸的两个片状物66。弯曲的下边缘64形成单个的扇贝形。当固定于两个其他的小叶以形成小叶结构14时，小叶的弯曲下边缘形成小叶结构的扇贝形下边缘部分(如图18最好地所示)。正如图13进一步示出的，两个加强杆62可以邻近片状物66固定于小叶(例如用缝合线)。然后片状物能够折叠在杆62上，并且用缝合线固定在折叠位置。如果希望，如图12所示，每个杆62可以在连接于小叶之前放置在保护套筒68(例如PET套筒)中。 
如图14所示，小叶的弯曲下边缘64为了后来固定于裙部16可以被加强，例如可以通过将加强带68沿着小叶的弯曲下边缘固定于在小叶相对杆62旁边的片状物66之间。三个这样的小叶60可以用相同的方式制造，并且然后以三尖瓣结构在片状物66处相互连接，以形成小叶结构14，如图15所示。小叶上的加强带68共同形成沿着小叶结构的内表面的下边缘部分延伸的带状物或套筒。 
正如上面所指出的，小叶结构14可以用裙部16固定于框架12。希望裙部16包括诸如PET的韧性的、抗裂纹的材料，尽管可以用各种其他天然或合成材料。裙部16可以比传统的裙部薄很多。例如，在一 个实施例中，裙部16是PET裙部，在其边缘处具有约0.07mm的厚度，并且在其中间处具有约0.06mm的厚度。比较薄的裙部能够提供更好的卷曲性能同时仍然具有良好的瓣膜周边的密封。 
图16示出在相对两端相互连接形成图17所示的环形形状之前裙部的展开图。如图所示，希望裙部16的上边缘具有波浪形的形状，该波浪形的形状大致遵循框架的第二行支杆22的形状。以这种方式，裙部16的上边缘能够用缝线56紧固地固定于支杆22(如图1所示)。裙部16也可以形成有狭槽70，以便于将裙部连接于框架。当裙部固定于框架时狭槽70与支杆22的隆起结构26对齐。狭槽70的尺寸做成以便使裙部的上边缘部分能够围绕支杆22部分地被包裹，并且在连接过程中减少裙部中的应力。例如，在所示的实施例中，裙部16放置在框架12的里面并且裙部的上边缘部分围绕支杆22的上表面被包裹，并且用缝合线56固定在位。以这种方式围绕支杆22包裹裙部的上边缘部分提供裙部与框架的更强的和更耐久的连接。尽管没有示出，但是裙部的下边缘也能够做成与最下一行支杆22的外形大致相符的形状，以改善通过瓣膜的流入端的血液的流动。 
如图17进一步所示，各种缝合线路能够添加于裙部，以方便将裙部连接于小叶结构和框架。例如，扇贝形缝合线路72可以用作导向装置，以在适当的位置用缝合线59将小叶结构的下边缘缝合在裙部的内表面上(如图5最好地所示)。另一个扇贝形缝合线路74(图17)可以用作导向装置，以用缝合线58将小叶结构缝合于裙部(图1)。固定于小叶的下边缘的加强带68沿着缝合线路58加强小叶并且保护小叶不受撕裂。图18示出由裙部16和固定于裙部16的小叶结构14构成的小叶组件。然后该小叶组件能够以下面所述的方式固定于框架12。在可替换实施例中，没有小叶结构的裙部可以首先连接于框架，并且然后小叶结构可以连接于该裙部。 
图6示出连接于框架12的瓣膜组件的顶视图。小叶60在大致闭合的位置被示出。如图所示，小叶的接缝与框架的柱18对齐。利用延伸通过小叶的片状物66、加强杆62的开口76以及柱18的开口78的缝合线，有效地将片状物66固定于柱18，小叶能够固定于框架。正如上面所指出的，杆62在与柱的连接区域加强片状物，并且防止小叶撕 裂。 
如图6A所示，希望加强杆62垂直对齐，并且相对于框架的柱18尽可能直，使得杆62和在每个接缝处的柱18形成T形形状。杆62的宽度和通过杆的接缝的连接在小叶60的可偏转的部分(没有用缝合线缝合于框架的部分)和框架之间提供间隙，同时杆62的边缘半径(厚度)在瓣膜打开和关闭过程中用作小叶60的柔性铰链，因而增加小叶和框架之间的空间。通过增加小叶的运动部分和框架之间的空间，并且通过使小叶弯曲向杆62的边缘半径，在工作循环期间能够避免小叶的运动部分(具体说小叶的流出边缘)和框架之间的接触，这进而又改善瓣膜组件的耐久性。这种结构还增强通过冠状窦的灌注。 
图19示出卷曲在气囊输送导管100上的瓣膜10的侧视图。该瓣膜卷曲在气囊导管100的气囊110上。希望在卷曲期间保护瓣膜的小叶结构14不受损坏，以确保小叶结构的耐久性，同时希望尽可能减少瓣膜的卷曲的外形尺寸。在卷曲过程期间，小叶结构的组织(例如，牛心包组织或其他合适的组织)压向金属框架的内表面，并且该组织的(多个)部分能够挤进支杆之间的框架的开口网眼中，并且由于框架支杆的剪刀状的运动而能被夹紧。如果瓣膜被严密卷曲以实现小卷曲尺寸，那么这种剪刀状的运动能够导致该组织小叶的切割和破裂。 
上面所述的裙部16在卷曲成某种程度期间能够防止损坏小叶结构。但是，裙部的主要目的是结构性的，并且在一些实施例中不覆盖整个框架。因此，在这样的实施例中，在卷曲期间裙部可能不完全保护小叶结构，并且因此，框架仍然能够引起对小叶结构的损坏。 
图20和图21示出用于以进一步保护小叶不受损坏的方式将瓣膜无损伤卷曲在气囊上的卷曲装置的实施例。该卷曲装置(也叫做卷曲器)总的用附图标记200表示，具有尺寸做成接纳扩张状态的瓣膜的小孔202。图20示出完全打开或扩张状态的小孔202，其中瓣膜10设置在小孔202的里面。卷曲装置200具有多个卷曲爪206(在所示的实施例中为12个)，卷曲爪206被配置成径向向里运动，以围绕气囊导管的气囊将瓣膜径向压缩(卷曲)成较小的外形。 
可变形的材料设置在框架外侧和卷曲爪206之间。在所示的实施例中，可变形的材料包括围绕瓣膜设置的保护套筒或覆盖物204，以便 覆盖瓣膜的框架的外表面并且防止卷曲爪的硬表面直接接触瓣膜的框架。希望套筒204尺寸做成完全覆盖框架的外表面。希望套筒204用柔软的可弯曲并可压缩的材料制造。套筒可以用通常可得到的材料形成，包括但不限于天然的或合成的海绵(例如聚氨酯海绵)、由诸如聚氨酯或聚乙烯的合适的聚合物制成的泡沫材料，或任何各种合适的弹性体材料，例如聚氨酯、硅、聚烯烃或各种水凝胶等，仅作为几种示例。 
使用前希望将套筒存放在潮湿的环境中(例如浸没在盐水中)。在围绕瓣膜放置套筒204之后，瓣膜和套筒被放进卷曲装置200中，如图20所示。然后气囊导管的气囊110可以设置在瓣膜的小叶60内(图21)。图21示出围绕套筒204的卷曲爪206，套筒204又进而围绕瓣膜10的框架12和小叶结构14。气囊110通常放置在瓣膜的中心以便在瓣膜被植入体内期间瓣膜能够均匀地扩张。 
正如从图21所见，在卷曲期间，保护套筒204的海绵状材料伸进框架12的开口网眼中并占据这个空间，因而防止小叶结构14进入这个空间并且被夹紧或损坏。在卷曲完成之后，具有保护套筒的瓣膜从卷曲装置取出。然后套筒204能够轻轻地从框架剥离。由于在卷曲期间保护套筒向里压紧小叶结构并离开框架，瓣膜能够卷曲成小外形而不损坏小叶结构。 
图23和24示出通过利用保护套筒204得到的优点。图23示出不用保护套筒卷曲的人工瓣膜。虚线300表示小叶结构302已经被压紧在如上所述能够损坏小叶结构的框架304的支杆之间。 
相反，图24示出用保护套筒204而卷曲的人工瓣膜。在这个例子中，小叶结构302被向里压紧并离开框架304的内侧，因此，小叶结构不被夹紧或挤压在框架的支杆之间。 
因此，当使用保护套筒时由于小叶结构被推离框架，因此在卷曲过程中小叶结构不太可能被夹紧或切割。而且，当利用保护套筒时，能够实现非常有序的气囊-小叶-框架结构(从里向外)。当没有这种套筒时，气囊、小叶和框架的一些部分在卷曲过程之后很可能重叠并且结果得到的结构是较不可预知和较不均匀的。 
除了上面所述的泡沫和海绵型保护套筒之外，也可以用由其他类 型的可变形材料制成的套筒或保护层，以在瓣膜卷曲期间保护小叶不受损坏。在一个实施例中，例如，可变形材料(例如海绵、橡胶、硅、聚氨酯等)的层(例如矩形片)可以设置在每个卷曲爪206上，以便在卷曲时形成围绕瓣膜的套筒。可替换地，用诸如凝胶或气体的可流动、可变形材料填充的可变形包可以设置在每个卷曲爪上，用于卷曲时与瓣膜接触。此外，在许多其他织物材料或其他合适的材料中，可变形材料(例如套筒204)可以用薄PET布覆盖，以防止在卷曲期间可变形材料的颗粒物进入瓣膜中。 
人造瓣膜的裙部用于多种功能。在具体实施例中，例如，裙部起密封作用以密封并防止(减少)瓣膜周边泄漏，以将小叶结构固定到框架，并且保护小叶在卷曲期间和在瓣膜工作循环期间不受由接触框架所引起的损坏。上面所述的与人工瓣膜一起使用的裙部被描述为诸如PET布的织物。PET或其他织物基本上是无弹性的(即，基本上是不可拉伸的或不可压缩的)。这样，在某些实施例中的裙部限制瓣膜的最小可实现的卷曲直径并且在从卷曲直径扩张之后能够起皱。 
在例如下面讨论的可替换实施例中，人工瓣膜可以具有用可拉伸和/或可压缩材料(例如硅)制造的裙部。由于这种裙部的可压缩性，与具有不可压缩的裙部的瓣膜相比，该瓣膜能够卷曲成相对小的直径。而且，从卷曲状态扩张之后这种裙部可以恢复到其原来很少有或没有皱褶的平滑表面。 
图25示出框架12的实施例，框架12具有围绕框架外面完全延伸并覆盖框架外面的至少一部分的弹性的“外管”(over-tube)裙部或套筒340。在具体的实施例中，裙部340用硅制造，该裙部能够经受大变形同时保持其弹性。这种硅裙部可以是从外面覆盖框架12一部分的薄套筒。在所示实施例中，裙部的高度小于框架12的总高度，但是，裙部的高度可以变化并且不必是图25所示的高度。例如，裙部的高度与框架的高度相同或大于框架的高度，以便完全覆盖框架的外面。在可替换实施例中，裙部340可以用例如缝合线或粘结剂安装在框架的里面。当安装在框架的里面时，裙部可以保护小叶不受框架里面擦伤。可以用来形成裙部或套筒的其他材料包括但不限于，PTFE(聚四氟乙烯)、ePTFE(膨体聚四氟乙烯)、聚氨酯、聚烯烃、水凝胶、生物材 料(例如心包，或诸如胶原、明胶或透明质酸衍生物的生物聚合物)或其组合。 
在另一个实施例中，整个框架或其一部分可以浸渍在液化材料(例如、液态硅或上面描述的用于形成套筒340的任何材料，这些材料可以液化用于浸渍涂覆框架)中，以便将整个框架(或至少被浸没的部分)密封在硅中。图26是框架12的侧视图，该框架浸渍在硅中以形成密封框架的支杆并且填充支杆之间的空间的连续的圆柱形硅覆盖层342。图26示出在覆盖层被修整以除去延伸超过框架端部的多余的材料之前的覆盖层342。尽管不太希望，但是可以浸渍框架使得硅密封框架的支杆，但是不填充框架支杆之间的开口空间。 
图27示出包括框架402和安装在该框架里面(例如，如图所示用缝合线)的小叶结构404的人工瓣膜400的实施例。框架402具有呈硅覆盖层406形式的裙部，该裙部例如通过将框架浸渍在液体硅中形成。图27示出在其扩张状态的人工瓣膜400。在图28中，瓣膜400已经被卷曲成较小的外形。在卷曲期间，延伸过并且填充框架支杆之间的开口网眼的涂层406有效地向里推小叶结构404并且推离该框架，因而，保护小叶结构不被夹紧或撕裂。图29示出被气囊导管的气囊扩张之后的瓣膜400。 
为了测试所用硅的耐久性和抗拉性，进行若干个单轴测试。具体说，大约5×50mm的硅带(其厚度约为0.85mm)在单轴测试机中测试。图30A-30C示出硅带的单轴测试的结果的曲线图。此外，在带的中间位置和带的边缘有意地将裂纹引进硅带中，同时在单轴测试机上拉伸该带。裂纹通过在硅带中用针形成孔而被引进。图31A-31F示出具有故意引进的裂纹的硅带的单轴测试结果的曲线图。 
已发现，硅薄层的最终张力拉伸在500％以上并且具有有意引进的裂纹的试验样品同样表现出很好的强度。因此，硅的弹性允许硅浸渍过的框架被卷曲成很小的外形并且扩张回较大的外形而不明显损坏硅层。此外，硅材料能够增加框架和人工瓣膜被植入其中的自体环之间的摩擦，结果得到较好的固定并且防止/减少瓣膜周边泄漏。 
硅裙部可以通过各种手段安装在框架上，包括利用心轴。而且，可以希望以与布裙部或织物裙部组合的方式利用硅裙部。例如，可以 希望将硅裙部放置在至少围绕框架一部分的布裙部或织物裙部的外面。 
可替换地或附加地，硅裙部也可以放置在框架里面并且连接于框架，以便在工作循环期间它为小叶提供改进的保护。可替换地，作为硅的替代，裙部可以用增大的和/或膨胀的材料，例如合成的或天然的水凝胶。增大的材料是一种横向扩张同时纵向拉伸的材料，这意味着这种材料具有负泊松比。如果框架用增大的材料覆盖，当瓣膜从其卷曲状态扩张时，它能够径向地扩张同时被圆周地拉伸。这种扩张能够改善瓣膜在自体瓣膜环处的配合，因而防止或减少瓣膜周边的泄漏。 
鉴于本实用新型的原理能够应用于其中的许多可能的实施例，应当认识到，举例说明的实施例仅仅是本实用新型优选的例子，并且不应当限制本实用新型的范围。而是本实用新型的范围由所附权利要求限定。因此请求保护的实用新型在这些权利要求的范围和精神内。 

Claims (13)

1.一种可植入的人工瓣膜(10)，其特征在于包括：
径向可收缩并且可扩张的环形框架(12)，该框架具有三个接缝连接柱(18)和在所述接缝连接柱之间延伸的三行圆周支杆，第一行圆周支杆(20)限定所述框架的流入端，而与所述第一行间隔开的第二圆周支杆和第三行圆周支杆(22，24)邻近所述框架的流出端，所述第一行通过多个轴向支杆(30)连接于所述第二行和所述第三行，每行圆周支杆包括成角度的支杆，该成角度的支杆布置成Z字形图形并且通过大致U形的隆起结构(26)相互连接以便改进可收缩性；
包括由心包组织形成的三个小叶(60)的小叶结构(14)，每个小叶具有上边缘、弯曲的下边缘(64)和两个侧面片状物(66)，其中每个侧面片状物固定于另一个小叶的相邻的侧面片状物，以形成所述小叶结构的接缝(84)，每个接缝连接于所述接缝连接柱中的一个；
设置在所述环形框架和所述小叶结构之间的环形的裙部部件(16)，每个小叶的所述弯曲的下边缘沿着扇贝形路线(58)缝合于所述裙部部件的内表面；以及
邻近每个接缝连接柱设置的成对加强杆(62)，每个加强杆包括多个孔，其中每个侧面片状物围绕一个加强杆延伸，并且每个加强杆缝合于一个接缝连接柱，用于加强所述小叶结构和所述接缝连接柱之间的连接。
2.根据权利要求1所述的人工瓣膜，其特征在于其中所述小叶结构的所述接缝用延伸通过所述侧面片状物、所述加强杆和所述接缝连接柱的缝合线连接于所述接缝连接柱。
3.根据权利要求1所述的人工瓣膜，其特征在于其中每个加强杆被保护套筒覆盖。
4.根据权利要求1所述的人工瓣膜，其特征在于还包括密封所述框架的至少一部分的环形弹性层(340)。 
5.根据权利要求1所述的人工瓣膜，其特征在于其中当所述环形框架处于扩张状态时所述成角度的支杆以大约90度和110度之间的角度A连接。
6.根据权利要求1所述的人工瓣膜，其特征在于其中所述框架包括镍钴铬合金。
7.根据权利要求6所述的人工瓣膜，其特征在于其中所述镍钴铬合金包括MP35N。
8.根据权利要求1所述的人工瓣膜，其特征在于还包括固定于小叶的所述下边缘部分的内表面的加强带(68)，使得所述小叶被夹在所述环形裙部部件和所述加强带之间。
9.根据权利要求1所述的人工瓣膜，其特征在于其中所述第一行的支杆比所述第二行和所述第三行的支杆厚。
10.根据权利要求1所述的人工瓣膜，其特征在于其中所述环形框架是可塑性扩张的。
11.根据权利要求1所述的人工瓣膜，其特征在于其中每个加强杆具有四个孔，这四个孔对应于形成在每个接缝连接柱中的四个孔。
12.根据权利要求1所述的人工瓣膜，其特征在于其中所述第一行和所述第二行圆周支杆具有平行的Z字形图形。
13.根据权利要求12所述的人工瓣膜，其特征在于其中所述第三行圆周支杆的所述Z字形图形与所述第一行和所述第二行圆周支杆的Z字形图形相反。 
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104661618A (zh) * 2012-04-23 2015-05-27 奥泰克国际有限公司 瓣膜
CN105431109A (zh) * 2013-12-17 2016-03-23 爱德华兹生命科学公司 反向小叶人工瓣膜
CN105979911A (zh) * 2013-12-05 2016-09-28 爱德华兹生命科学公司 人工心脏瓣膜和递送装置
CN106102658A (zh) * 2014-03-14 2016-11-09 杭州启明医疗器械有限公司 包括与瓣叶、顶部封套和底部封套互连的冠形件的心脏瓣膜；及医学植入物
CN106999282A (zh) * 2014-12-14 2017-08-01 特瑞森医疗有限公司 假体瓣膜和展开系统
CN109414322A (zh) * 2017-04-07 2019-03-01 上海甲悦医疗器械有限公司 一种人工瓣膜
CN109952077A (zh) * 2016-12-06 2019-06-28 爱德华兹生命科学公司 可机械扩张的心脏瓣膜和其递送设备
CN111685915A (zh) * 2013-03-13 2020-09-22 爱德华兹生命科学卡迪尔克有限责任公司 铰接式连合瓣膜支架和方法

Families Citing this family (667)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
US9579194B2 (en) * 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
NL1026076C2 (nl) 2004-04-29 2005-11-01 Univ Eindhoven Tech Vormdeel vervaardigd door middel van elektro-spinnen en een werkwijze voor de vervaardiging daarvan evenals de toepassing van een dergelijk vormdeel.
US9526584B2 (en) * 2004-09-21 2016-12-27 Airxpanders, Inc. Tissue expanders, implants, and methods of use
AU2004324043A1 (en) 2004-10-02 2006-04-20 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8092520B2 (en) 2005-11-10 2012-01-10 CardiAQ Technologies, Inc. Vascular prosthesis connecting stent
US20080004696A1 (en) * 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
WO2008013915A2 (en) 2006-07-28 2008-01-31 Arshad Quadri Percutaneous valve prosthesis and system and method for implanting same
AU2007281553B2 (en) 2006-07-31 2013-09-19 Edwards Lifesciences Cardiaq Llc Sealable endovascular implants and methods for their use
US9408607B2 (en) 2009-07-02 2016-08-09 Edwards Lifesciences Cardiaq Llc Surgical implant devices and methods for their manufacture and use
US9585743B2 (en) 2006-07-31 2017-03-07 Edwards Lifesciences Cardiaq Llc Surgical implant devices and methods for their manufacture and use
US9867530B2 (en) 2006-08-14 2018-01-16 Volcano Corporation Telescopic side port catheter device with imaging system and method for accessing side branch occlusions
CA2764601A1 (en) * 2006-10-23 2008-05-02 Valvexchange Inc. Cardiovascular valve and assembly
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
US8105375B2 (en) * 2007-01-19 2012-01-31 The Cleveland Clinic Foundation Method for implanting a cardiovascular valve
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US7815677B2 (en) * 2007-07-09 2010-10-19 Leman Cardiovascular Sa Reinforcement device for a biological valve and reinforced biological valve
WO2009009802A1 (en) 2007-07-12 2009-01-15 Volcano Corporation Oct-ivus catheter for concurrent luminal imaging
WO2009009799A1 (en) 2007-07-12 2009-01-15 Volcano Corporation Catheter for in vivo imaging
US9596993B2 (en) 2007-07-12 2017-03-21 Volcano Corporation Automatic calibration systems and methods of use
DE102007034363A1 (de) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Endoprothese
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US8728154B2 (en) 2007-08-24 2014-05-20 St. Jude Medical, Inc. Prosthetic aortic heart valves
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
DE202008018589U1 (de) 2007-09-26 2016-03-14 St. Jude Medical, Inc. Zusammenfaltbare Herzklappenprothesen
WO2009045334A1 (en) 2007-09-28 2009-04-09 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
EP4079261A1 (en) 2007-12-14 2022-10-26 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
JP5687070B2 (ja) 2008-01-24 2015-03-18 メドトロニック，インコーポレイテッド 人工心臓弁用のステント
EP2254512B1 (en) 2008-01-24 2016-01-06 Medtronic, Inc. Markers for prosthetic heart valves
US8157852B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
WO2009094197A1 (en) * 2008-01-24 2009-07-30 Medtronic, Inc. Stents for prosthetic heart valves
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
CA2961051C (en) 2008-02-29 2020-01-14 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
US8696743B2 (en) * 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
WO2009149462A2 (en) 2008-06-06 2009-12-10 Edwards Lifesciences Corporation Low profile transcatheter heart valve
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2010008548A2 (en) 2008-07-15 2010-01-21 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
EP2331015A1 (en) * 2008-09-12 2011-06-15 ValveXchange Inc. Valve assembly with exchangeable valve member and a tool set for exchanging the valve member
EP2367505B1 (en) 2008-09-29 2020-08-12 Edwards Lifesciences CardiAQ LLC Heart valve
CA2739275C (en) 2008-10-01 2017-01-17 Impala, Inc. Delivery system for vascular implant
US8690936B2 (en) 2008-10-10 2014-04-08 Edwards Lifesciences Corporation Expandable sheath for introducing an endovascular delivery device into a body
US9402720B2 (en) 2009-01-12 2016-08-02 Valve Medical Ltd. Modular percutaneous valve structure and delivery method
WO2010098857A1 (en) 2009-02-27 2010-09-02 St. Jude Medical, Inc. Stent features for collapsible prosthetic heart valves
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
EP2421479A2 (en) * 2009-04-24 2012-02-29 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Stent for valve replacement
US8075611B2 (en) * 2009-06-02 2011-12-13 Medtronic, Inc. Stented prosthetic heart valves
US8475522B2 (en) 2009-07-14 2013-07-02 Edwards Lifesciences Corporation Transapical delivery system for heart valves
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US20110313515A1 (en) 2010-06-21 2011-12-22 Arshad Quadri Replacement heart valve
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
WO2011072084A2 (en) * 2009-12-08 2011-06-16 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
AU2015230879B2 (en) * 2009-12-08 2017-06-15 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
US8795354B2 (en) * 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
WO2011111047A2 (en) 2010-03-10 2011-09-15 Mitraltech Ltd. Prosthetic mitral valve with tissue anchors
NZ602066A (en) 2010-03-23 2013-09-27 Edwards Lifesciences Corp Methods of conditioning sheet bioprosthetic tissue
AU2014233651B2 (en) * 2010-03-23 2016-05-19 Edwards Lifesciences Corporation Methods of conditioning sheet bioprosthetic tissue
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CN102883684B (zh) 2010-05-10 2015-04-08 爱德华兹生命科学公司 人工心脏瓣膜
JP2013526388A (ja) 2010-05-25 2013-06-24 イエナバルブ テクノロジー インク 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ
US9795476B2 (en) 2010-06-17 2017-10-24 St. Jude Medical, Llc Collapsible heart valve with angled frame
AU2011276503B2 (en) 2010-06-28 2015-09-17 Colibri Heart Value LLC Method and apparatus for the endoluminal delivery of intravascular devices
JP5848345B2 (ja) 2010-07-09 2016-01-27 ハイライフ エスエーエス 経カテーテル式房室弁人工器官
US8657872B2 (en) 2010-07-19 2014-02-25 Jacques Seguin Cardiac valve repair system and methods of use
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
WO2012012761A2 (en) 2010-07-23 2012-01-26 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
WO2012021527A2 (en) * 2010-08-09 2012-02-16 Valvexchange, Inc. Temporary sub-valvular check valve
EP2605729A2 (en) * 2010-08-17 2013-06-26 St. Jude Medical, Cardiology Division, Inc. A device for collapsing and loading a heart valve into a minimally invasive delivery system
US9039759B2 (en) * 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
JP5891228B2 (ja) 2010-08-24 2016-03-22 セント・ジュード・メディカル，インコーポレイテッド 経カテーテル心臓弁送達システム用の段階的展開装置および方法
EP2608815B1 (en) * 2010-08-24 2018-03-21 Collagen Solutions NZ Limited Biomaterials with enhanced properties and devices made therefrom
AU2015202239B2 (en) * 2010-08-24 2016-11-17 Collagen Solutions Nz Limited Biomaterials with enhanced properties and devices made therefrom
CN106073946B (zh) * 2010-09-10 2022-01-04 西美蒂斯股份公司 瓣膜置换装置、用于瓣膜置换装置的递送装置以及瓣膜置换装置的生产方法
JP2013541366A (ja) 2010-09-17 2013-11-14 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 経カテーテル心臓弁送達用の段階的展開装置および方法
USD653341S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical stent
USD648854S1 (en) 2010-09-20 2011-11-15 St. Jude Medical, Inc. Commissure points
USD653342S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Stent connections
USD652926S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Forked end
USD684692S1 (en) 2010-09-20 2013-06-18 St. Jude Medical, Inc. Forked ends
WO2012039753A2 (en) 2010-09-20 2012-03-29 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
USD654169S1 (en) 2010-09-20 2012-02-14 St. Jude Medical Inc. Forked ends
USD653343S1 (en) 2010-09-20 2012-01-31 St. Jude Medical, Inc. Surgical cuff
USD660967S1 (en) 2010-09-20 2012-05-29 St. Jude Medical, Inc. Surgical stent
USD652927S1 (en) 2010-09-20 2012-01-24 St. Jude Medical, Inc. Surgical stent
USD654170S1 (en) 2010-09-20 2012-02-14 St. Jude Medical, Inc. Stent connections
USD660433S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Surgical stent assembly
USD660432S1 (en) 2010-09-20 2012-05-22 St. Jude Medical, Inc. Commissure point
WO2012040655A2 (en) 2010-09-23 2012-03-29 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
WO2012040643A2 (en) * 2010-09-23 2012-03-29 Colibri Heart Valve Llc Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane
CN103118630B (zh) 2010-09-24 2016-05-04 西美蒂斯股份公司 支架瓣膜、输送设备和输送方法
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
DE202011111128U1 (de) * 2010-10-05 2020-05-27 Edwards Lifesciences Corporation Prothetische Herzklappe
CN105380730B (zh) * 2010-10-05 2018-08-17 爱德华兹生命科学公司 人工心脏瓣膜
AU2015268755B2 (en) * 2010-10-05 2017-06-15 Edwards Lifesciences Corporation Prosthetic heart valve
US8562663B2 (en) 2010-10-26 2013-10-22 Medtronic Ventor Technologies Ltd. Devices and methods for loading a prosthesis onto a delivery system
SG10201601962WA (en) 2010-12-14 2016-04-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US11141063B2 (en) 2010-12-23 2021-10-12 Philips Image Guided Therapy Corporation Integrated system architectures and methods of use
US11040140B2 (en) 2010-12-31 2021-06-22 Philips Image Guided Therapy Corporation Deep vein thrombosis therapeutic methods
CA2822072A1 (en) * 2011-01-06 2012-07-12 Valvexchange Inc. Resizable valve base for cardiovascular valve assembly
US9717593B2 (en) 2011-02-01 2017-08-01 St. Jude Medical, Cardiology Division, Inc. Leaflet suturing to commissure points for prosthetic heart valve
US9155619B2 (en) * 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9554900B2 (en) 2011-04-01 2017-01-31 W. L. Gore & Associates, Inc. Durable high strength polymer composites suitable for implant and articles produced therefrom
US9801712B2 (en) 2011-04-01 2017-10-31 W. L. Gore & Associates, Inc. Coherent single layer high strength synthetic polymer composites for prosthetic valves
US8945212B2 (en) 2011-04-01 2015-02-03 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
US9744033B2 (en) 2011-04-01 2017-08-29 W.L. Gore & Associates, Inc. Elastomeric leaflet for prosthetic heart valves
US8961599B2 (en) 2011-04-01 2015-02-24 W. L. Gore & Associates, Inc. Durable high strength polymer composite suitable for implant and articles produced therefrom
US20130197631A1 (en) 2011-04-01 2013-08-01 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US8945209B2 (en) * 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
US8795357B2 (en) * 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP4289398A3 (en) 2011-08-11 2024-03-13 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US9060860B2 (en) 2011-08-18 2015-06-23 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
WO2013033489A1 (en) 2011-08-31 2013-03-07 Volcano Corporation Optical rotary joint and methods of use
US9554806B2 (en) 2011-09-16 2017-01-31 W. L. Gore & Associates, Inc. Occlusive devices
US9474598B2 (en) 2011-10-05 2016-10-25 Boston Scientific Scimed, Inc. Profile reduction seal
EP2768432A1 (en) 2011-10-21 2014-08-27 JenaValve Technology Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US9480558B2 (en) 2011-12-05 2016-11-01 Medtronic, Inc. Transcatheter valve having reduced seam exposure
CA3051684C (en) 2011-12-06 2020-06-16 Aortic Innovations Llc Device for endovascular aortic repair and method of using the same
CA3201836A1 (en) 2011-12-09 2013-06-13 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US8652145B2 (en) 2011-12-14 2014-02-18 Edwards Lifesciences Corporation System and method for crimping a prosthetic valve
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
EP2614794A1 (de) * 2012-01-11 2013-07-17 Biotronik AG Herzklappenprothese
JP6049761B2 (ja) 2012-01-31 2016-12-21 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 僧帽弁ドッキングデバイス、システム、および方法
CA2865013C (en) 2012-02-22 2020-12-15 Syntheon Cardiology, Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US9878127B2 (en) 2012-05-16 2018-01-30 Jenavalve Technology, Inc. Catheter delivery system for heart valve prosthesis
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9289292B2 (en) * 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9554902B2 (en) * 2012-06-28 2017-01-31 St. Jude Medical, Cardiology Division, Inc. Leaflet in configuration for function in various shapes and sizes
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9808342B2 (en) 2012-07-03 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Balloon sizing device and method of positioning a prosthetic heart valve
US10004597B2 (en) 2012-07-03 2018-06-26 St. Jude Medical, Cardiology Division, Inc. Stent and implantable valve incorporating same
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US9510946B2 (en) 2012-09-06 2016-12-06 Edwards Lifesciences Corporation Heart valve sealing devices
US9286673B2 (en) 2012-10-05 2016-03-15 Volcano Corporation Systems for correcting distortions in a medical image and methods of use thereof
US9324141B2 (en) 2012-10-05 2016-04-26 Volcano Corporation Removal of A-scan streaking artifact
US9367965B2 (en) 2012-10-05 2016-06-14 Volcano Corporation Systems and methods for generating images of tissue
US9858668B2 (en) 2012-10-05 2018-01-02 Volcano Corporation Guidewire artifact removal in images
US10568586B2 (en) 2012-10-05 2020-02-25 Volcano Corporation Systems for indicating parameters in an imaging data set and methods of use
JP2015532536A (ja) 2012-10-05 2015-11-09 デイビッド ウェルフォード， 光を増幅するためのシステムおよび方法
US10070827B2 (en) 2012-10-05 2018-09-11 Volcano Corporation Automatic image playback
US11272845B2 (en) 2012-10-05 2022-03-15 Philips Image Guided Therapy Corporation System and method for instant and automatic border detection
US9292918B2 (en) 2012-10-05 2016-03-22 Volcano Corporation Methods and systems for transforming luminal images
US9307926B2 (en) 2012-10-05 2016-04-12 Volcano Corporation Automatic stent detection
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
US10524909B2 (en) 2012-10-12 2020-01-07 St. Jude Medical, Cardiology Division, Inc. Retaining cage to permit resheathing of a tavi aortic-first transapical system
US9840734B2 (en) 2012-10-22 2017-12-12 Raindance Technologies, Inc. Methods for analyzing DNA
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
ES2931210T3 (es) 2012-11-21 2022-12-27 Edwards Lifesciences Corp Mecanismos de retención para válvulas cardiacas protésicas
EP2931132B1 (en) 2012-12-13 2023-07-05 Philips Image Guided Therapy Corporation System for targeted cannulation
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US9398952B2 (en) 2012-12-19 2016-07-26 W. L. Gore & Associates, Inc. Planar zone in prosthetic heart valve leaflet
US10321986B2 (en) 2012-12-19 2019-06-18 W. L. Gore & Associates, Inc. Multi-frame prosthetic heart valve
US10966820B2 (en) 2012-12-19 2021-04-06 W. L. Gore & Associates, Inc. Geometric control of bending character in prosthetic heart valve leaflets
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US10942022B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Manual calibration of imaging system
US11406498B2 (en) 2012-12-20 2022-08-09 Philips Image Guided Therapy Corporation Implant delivery system and implants
WO2014099899A1 (en) 2012-12-20 2014-06-26 Jeremy Stigall Smooth transition catheters
US10939826B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Aspirating and removing biological material
JP2016506276A (ja) 2012-12-20 2016-03-03 ジェレミー スティガール， 血管内画像の位置の特定
US9709379B2 (en) 2012-12-20 2017-07-18 Volcano Corporation Optical coherence tomography system that is reconfigurable between different imaging modes
US10993694B2 (en) 2012-12-21 2021-05-04 Philips Image Guided Therapy Corporation Rotational ultrasound imaging catheter with extended catheter body telescope
US9612105B2 (en) 2012-12-21 2017-04-04 Volcano Corporation Polarization sensitive optical coherence tomography system
WO2014099672A1 (en) 2012-12-21 2014-06-26 Andrew Hancock System and method for multipath processing of image signals
CA2895993A1 (en) 2012-12-21 2014-06-26 Jason Spencer System and method for graphical processing of medical data
US10058284B2 (en) 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
US10191220B2 (en) 2012-12-21 2019-01-29 Volcano Corporation Power-efficient optical circuit
US10413317B2 (en) 2012-12-21 2019-09-17 Volcano Corporation System and method for catheter steering and operation
US9383263B2 (en) 2012-12-21 2016-07-05 Volcano Corporation Systems and methods for narrowing a wavelength emission of light
US10166003B2 (en) 2012-12-21 2019-01-01 Volcano Corporation Ultrasound imaging with variable line density
US9486143B2 (en) 2012-12-21 2016-11-08 Volcano Corporation Intravascular forward imaging device
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
US9314163B2 (en) 2013-01-29 2016-04-19 St. Jude Medical, Cardiology Division, Inc. Tissue sensing device for sutureless valve selection
US9655719B2 (en) 2013-01-29 2017-05-23 St. Jude Medical, Cardiology Division, Inc. Surgical heart valve flexible stent frame stiffener
US9186238B2 (en) 2013-01-29 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Aortic great vessel protection
US9308346B2 (en) 2013-02-01 2016-04-12 Medtronic, Inc. Devices and methods for crimping and loading a collapsible device into a delivery system
US9308569B2 (en) 2013-02-01 2016-04-12 Medtronic, Inc. Devices and methods for crimping and loading a medical device into a delivery system
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
AU2014214700B2 (en) * 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
CN104000672B (zh) 2013-02-25 2016-06-15 上海微创心通医疗科技有限公司 心脏瓣膜假体
US9901470B2 (en) 2013-03-01 2018-02-27 St. Jude Medical, Cardiology Division, Inc. Methods of repositioning a transcatheter heart valve after full deployment
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
JP6243453B2 (ja) 2013-03-07 2017-12-06 ボルケーノ コーポレイション 血管内画像におけるマルチモーダルセグメンテーション
US10226597B2 (en) 2013-03-07 2019-03-12 Volcano Corporation Guidewire with centering mechanism
US9480563B2 (en) 2013-03-08 2016-11-01 St. Jude Medical, Cardiology Division, Inc. Valve holder with leaflet protection
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US10271949B2 (en) 2013-03-12 2019-04-30 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
CN105228518B (zh) 2013-03-12 2018-10-09 火山公司 用于诊断冠状微脉管疾病的系统和方法
US20140276923A1 (en) 2013-03-12 2014-09-18 Volcano Corporation Vibrating catheter and methods of use
US9398951B2 (en) 2013-03-12 2016-07-26 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US10314698B2 (en) 2013-03-12 2019-06-11 St. Jude Medical, Cardiology Division, Inc. Thermally-activated biocompatible foam occlusion device for self-expanding heart valves
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9301687B2 (en) 2013-03-13 2016-04-05 Volcano Corporation System and method for OCT depth calibration
US10758207B2 (en) 2013-03-13 2020-09-01 Philips Image Guided Therapy Corporation Systems and methods for producing an image from a rotational intravascular ultrasound device
US11026591B2 (en) 2013-03-13 2021-06-08 Philips Image Guided Therapy Corporation Intravascular pressure sensor calibration
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US10219887B2 (en) 2013-03-14 2019-03-05 Volcano Corporation Filters with echogenic characteristics
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US10292677B2 (en) 2013-03-14 2019-05-21 Volcano Corporation Endoluminal filter having enhanced echogenic properties
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
US20160030151A1 (en) 2013-03-14 2016-02-04 Volcano Corporation Filters with echogenic characteristics
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US11224510B2 (en) 2013-04-02 2022-01-18 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
CA2908342C (en) 2013-05-20 2021-11-30 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
EP3010446B2 (en) 2013-06-19 2024-03-20 AGA Medical Corporation Collapsible valve having paravalvular leak protection
WO2014203106A1 (en) * 2013-06-21 2014-12-24 Jenavalve Technology Gmbh Collapsible prosthetic heart valve
JP6461122B2 (ja) 2013-06-25 2019-01-30 テンダイン ホールディングス，インコーポレイテッド 人工心臓弁の血栓管理及び構造コンプライアンス特徴
US9668856B2 (en) 2013-06-26 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Puckering seal for reduced paravalvular leakage
US11911258B2 (en) 2013-06-26 2024-02-27 W. L. Gore & Associates, Inc. Space filling devices
EP3016595B1 (en) 2013-07-26 2018-12-19 Edwards Lifesciences CardiAQ LLC Systems for sealing openings in an anatomical wall
EP3027144B1 (en) 2013-08-01 2017-11-08 Tendyne Holdings, Inc. Epicardial anchor devices
SG10202103500PA (en) 2013-08-12 2021-05-28 Mitral Valve Tech Sarl Apparatus and methods for implanting a replacement heart valve
JP6328242B2 (ja) 2013-08-14 2018-05-23 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 心臓弁置換のためのシステム
US10052198B2 (en) 2013-08-14 2018-08-21 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
CN105491978A (zh) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 用于假体瓣膜的径向可折叠框架及其制造方法
USD730521S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
USD730520S1 (en) 2013-09-04 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Stent with commissure attachments
US9867611B2 (en) 2013-09-05 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Anchoring studs for transcatheter valve implantation
WO2015038458A1 (en) * 2013-09-12 2015-03-19 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
DE102013220584A1 (de) * 2013-10-11 2015-04-16 Robert Bosch Gmbh Steuerventil
WO2015058039A1 (en) 2013-10-17 2015-04-23 Robert Vidlund Apparatus and methods for alignment and deployment of intracardiac devices
EP3656353A1 (en) 2013-10-28 2020-05-27 Tendyne Holdings, Inc. Prosthetic heart valve and systems for delivering the same
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
CN103550015B (zh) * 2013-11-01 2015-07-01 金仕生物科技（常熟）有限公司 一种人工心脏瓣膜瓣架和采用此瓣架的介入人工心脏瓣膜
US9700409B2 (en) 2013-11-06 2017-07-11 St. Jude Medical, Cardiology Division, Inc. Reduced profile prosthetic heart valve
EP2870946B1 (en) 2013-11-06 2018-10-31 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
US9913715B2 (en) 2013-11-06 2018-03-13 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
CR20160240A (es) 2013-11-11 2016-08-04 Edwards Lifesciences Cardiaq Llc Sistemas y métodos para la manufactura del marco de una cánula
EP3068344A1 (en) 2013-11-12 2016-09-21 St. Jude Medical, Cardiology Division, Inc. Pneumatically power-assisted tavi delivery system
WO2015077274A1 (en) 2013-11-19 2015-05-28 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10314693B2 (en) 2013-11-27 2019-06-11 St. Jude Medical, Cardiology Division, Inc. Cuff stitching reinforcement
US9597185B2 (en) 2013-12-19 2017-03-21 St. Jude Medical, Cardiology Division, Inc. Leaflet-cuff attachments for prosthetic heart valve
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US20150209141A1 (en) 2014-01-24 2015-07-30 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (pvl) reduction-passive channel filling cuff designs
WO2015120122A2 (en) 2014-02-05 2015-08-13 Robert Vidlund Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US10292711B2 (en) 2014-02-07 2019-05-21 St. Jude Medical, Cardiology Division, Inc. Mitral valve treatment device having left atrial appendage closure
EP2904967A1 (en) 2014-02-07 2015-08-12 St. Jude Medical, Cardiology Division, Inc. System and method for assessing dimensions and eccentricity of valve annulus for trans-catheter valve implantation
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
EP3107496B1 (en) 2014-02-18 2018-07-04 St. Jude Medical, Cardiology Division, Inc. Bowed runners for paravalvular leak protection
PT3107500T (pt) * 2014-02-18 2021-12-24 Edwards Lifesciences Corp Estrutura de comissura flexível
WO2015127283A1 (en) 2014-02-21 2015-08-27 Cardiaq Valve Technologies, Inc. Delivery device for controlled deployement of a replacement valve
EP3107498B1 (en) 2014-02-21 2020-09-30 Mitral Valve Technologies Sàrl Prosthetic mitral valve with anchoring device
US10130457B2 (en) * 2014-03-05 2018-11-20 Tela Bio, Inc. Surgical attachment device
AU2015229708B2 (en) 2014-03-10 2019-08-15 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
EP2921140A1 (en) 2014-03-18 2015-09-23 St. Jude Medical, Cardiology Division, Inc. Percutaneous valve anchoring for a prosthetic aortic valve
WO2015142648A1 (en) 2014-03-18 2015-09-24 St. Jude Medical, Cardiology Division, Inc. Mitral valve replacement toggle cell securement
EP3119352B1 (en) 2014-03-21 2023-12-20 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation
US20150272737A1 (en) 2014-03-26 2015-10-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve stent frames
WO2015152980A1 (en) 2014-03-31 2015-10-08 St. Jude Medical, Cardiology Division, Inc. Paravalvular sealing via extended cuff mechanisms
EP3131504B1 (en) 2014-04-14 2023-03-15 St. Jude Medical, Cardiology Division, Inc. Leaflet abrasion mitigation in prosthetic heart valves
US10195025B2 (en) * 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
EP3142604B1 (en) 2014-05-16 2024-01-10 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with paravalvular leak sealing ring
WO2015175524A1 (en) 2014-05-16 2015-11-19 St. Jude Medical, Cardiology Division, Inc. Subannular sealing for paravalvular leak protection
EP3142605A1 (en) 2014-05-16 2017-03-22 St. Jude Medical, Cardiology Division, Inc. Stent assembly for use in prosthetic heart valves
WO2015179423A1 (en) 2014-05-19 2015-11-26 Cardiaq Valve Technologies, Inc. Replacement mitral valve with annular flap
US10500042B2 (en) 2014-05-22 2019-12-10 St. Jude Medical, Cardiology Division, Inc. Stents with anchoring sections
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9855140B2 (en) 2014-06-10 2018-01-02 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
EP4066786A1 (en) 2014-07-30 2022-10-05 Cardiovalve Ltd. Articulatable prosthetic valve
EP3182932B1 (en) 2014-08-18 2019-05-15 St. Jude Medical, Cardiology Division, Inc. Annuloplasty ring with sensor
WO2016028581A1 (en) 2014-08-18 2016-02-25 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart devices having diagnostic capabilities
EP3182930B1 (en) 2014-08-18 2020-09-23 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
EP3182929B1 (en) 2014-08-18 2023-08-09 Edwards Lifesciences Corporation Frame with integral sewing cuff for prosthetic valves
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
CR20170245A (es) 2014-12-05 2017-09-14 Edwards Lifesciences Corp Cateter dirigible con cable de tracción
CA2971281C (en) * 2014-12-19 2023-02-21 Venus Medtech (Hangzhou), Inc. Minimally invasive mitral valve replacement with brim
EP3242630A2 (en) 2015-01-07 2017-11-15 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
CA2975294A1 (en) 2015-02-05 2016-08-11 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
EP3253333B1 (en) 2015-02-05 2024-04-03 Cardiovalve Ltd Prosthetic valve with axially-sliding frames
US10231834B2 (en) 2015-02-09 2019-03-19 Edwards Lifesciences Corporation Low profile transseptal catheter and implant system for minimally invasive valve procedure
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
WO2016138423A1 (en) 2015-02-27 2016-09-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis
JP6974916B2 (ja) 2015-02-27 2021-12-01 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 多弁尖の弁の電気紡績ステントレス製作のための二重構成要素マンドレル
US10314699B2 (en) 2015-03-13 2019-06-11 St. Jude Medical, Cardiology Division, Inc. Recapturable valve-graft combination and related methods
EP3273912A1 (en) 2015-03-23 2018-01-31 St. Jude Medical, Cardiology Division, Inc. Heart valve repair
EP3273911A1 (en) 2015-03-24 2018-01-31 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
EP3273910A2 (en) 2015-03-24 2018-01-31 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
EP3280359A1 (en) 2015-04-07 2018-02-14 St. Jude Medical, Cardiology Division, Inc. System and method for intraprocedural assessment of geometry and compliance of valve annulus for trans-catheter valve implantation
US10792471B2 (en) 2015-04-10 2020-10-06 Edwards Lifesciences Corporation Expandable sheath
US10327896B2 (en) 2015-04-10 2019-06-25 Edwards Lifesciences Corporation Expandable sheath with elastomeric cross sectional portions
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
CA2983002C (en) 2015-04-16 2023-07-04 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10232564B2 (en) * 2015-04-29 2019-03-19 Edwards Lifesciences Corporation Laminated sealing member for prosthetic heart valve
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
CN114652385A (zh) 2015-05-14 2022-06-24 W.L.戈尔及同仁股份有限公司 用于闭塞心耳的装置
EP3307207A1 (en) 2015-06-12 2018-04-18 St. Jude Medical, Cardiology Division, Inc. Heart valve repair and replacement
CA2990872C (en) * 2015-06-22 2022-03-22 Edwards Lifescience Cardiaq Llc Actively controllable heart valve implant and methods of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
EP3317448B1 (en) 2015-06-30 2021-09-08 Tela Bio, Inc. Corner-lock stitch patterns
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US10639149B2 (en) 2015-07-16 2020-05-05 St. Jude Medical, Cardiology Division, Inc. Sutureless prosthetic heart valve
US10327892B2 (en) 2015-08-11 2019-06-25 Boston Scientific Scimed Inc. Integrated adaptive seal for prosthetic heart valves
EP3334380B1 (en) 2015-08-12 2022-03-16 St. Jude Medical, Cardiology Division, Inc. Collapsible heart valve including stents with tapered struts
US10631977B2 (en) 2015-08-24 2020-04-28 Edwards Lifesciences Corporation Covering and assembly method for transcatheter valve
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US10350047B2 (en) 2015-09-02 2019-07-16 Edwards Lifesciences Corporation Method and system for packaging and preparing a prosthetic heart valve and associated delivery system
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US10314703B2 (en) 2015-09-21 2019-06-11 Edwards Lifesciences Corporation Cylindrical implant and balloon
US10470876B2 (en) 2015-11-10 2019-11-12 Edwards Lifesciences Corporation Transcatheter heart valve for replacing natural mitral valve
US10376364B2 (en) 2015-11-10 2019-08-13 Edwards Lifesciences Corporation Implant delivery capsule
US10321996B2 (en) 2015-11-11 2019-06-18 Edwards Lifesciences Corporation Prosthetic valve delivery apparatus having clutch mechanism
US11033387B2 (en) 2015-11-23 2021-06-15 Edwards Lifesciences Corporation Methods for controlled heart valve delivery
US10265169B2 (en) 2015-11-23 2019-04-23 Edwards Lifesciences Corporation Apparatus for controlled heart valve delivery
US10583007B2 (en) 2015-12-02 2020-03-10 Edwards Lifesciences Corporation Suture deployment of prosthetic heart valve
ES2777609T3 (es) 2015-12-03 2020-08-05 Tendyne Holdings Inc Características del marco para válvulas mitrales protésicas
US10357351B2 (en) 2015-12-04 2019-07-23 Edwards Lifesciences Corporation Storage assembly for prosthetic valve
US9931204B2 (en) 2015-12-10 2018-04-03 Medtronic, Inc. Transcatheter heart valve replacement systems, heart valve prostheses, and methods for percutaneous heart valve replacement
WO2017103830A1 (en) * 2015-12-15 2017-06-22 Meril Life Sciences Pvt Ltd Single tissue leaflets of a prosthetic valve
US10987216B2 (en) 2015-12-15 2021-04-27 Meril Life Sciences Pvt Ltd Prosthetic valve
CN108366859B (zh) 2015-12-28 2021-02-05 坦迪尼控股股份有限公司 用于假体心脏瓣膜的心房囊袋闭合件
US10433952B2 (en) 2016-01-29 2019-10-08 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
US10179043B2 (en) 2016-02-12 2019-01-15 Edwards Lifesciences Corporation Prosthetic heart valve having multi-level sealing member
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10779941B2 (en) 2016-03-08 2020-09-22 Edwards Lifesciences Corporation Delivery cylinder for prosthetic implant
US10398549B2 (en) 2016-03-15 2019-09-03 Abbott Cardiovascular Systems Inc. System and method for transcatheter heart valve platform
CA3216740A1 (en) 2016-03-24 2017-09-28 Edwards Lifesciences Corporation Delivery system for prosthetic heart valve
WO2017189772A1 (en) 2016-04-26 2017-11-02 Tela Bio, Inc. Hernia repair grafts having anti-adhesion barriers
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
EP3454795B1 (en) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system
USD802766S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
US10321994B2 (en) 2016-05-13 2019-06-18 St. Jude Medical, Cardiology Division, Inc. Heart valve with stent having varying cell densities
USD802765S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
USD802764S1 (en) 2016-05-13 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Surgical stent
EP3468480B1 (en) 2016-06-13 2023-01-11 Tendyne Holdings, Inc. Sequential delivery of two-part prosthetic mitral valve
WO2018005779A1 (en) 2016-06-30 2018-01-04 Tegels Zachary J Prosthetic heart valves and apparatus and methods for delivery of same
US11065116B2 (en) 2016-07-12 2021-07-20 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
US10350062B2 (en) * 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
RU2634418C1 (ru) * 2016-07-21 2017-10-26 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Протез аортального клапана сердца для транскатетерной имплантации
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
CN114587712A (zh) 2016-08-10 2022-06-07 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
EP3496606A1 (en) 2016-08-11 2019-06-19 Foundry Innovation & Research 1, Ltd. Systems and methods for patient fluid management
US11701018B2 (en) * 2016-08-11 2023-07-18 Foundry Innovation & Research 1, Ltd. Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore
WO2018035375A1 (en) 2016-08-19 2018-02-22 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve and methods of use
US10722359B2 (en) 2016-08-26 2020-07-28 Edwards Lifesciences Corporation Heart valve docking devices and systems
CR20190069A (es) 2016-08-26 2019-05-14 Edwards Lifesciences Corp Valvulas y sistemas de acoplamiento de valvulas corazon
DK3503848T3 (da) 2016-08-26 2021-11-15 Edwards Lifesciences Corp Erstatningshjerteklapprotese i flere dele
ES2902516T3 (es) 2016-08-26 2022-03-28 St Jude Medical Cardiology Div Inc Válvula cardiaca protésica con características de mitigación de fuga paravalvular
WO2018052927A1 (en) 2016-09-15 2018-03-22 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
US10575944B2 (en) 2016-09-22 2020-03-03 Edwards Lifesciences Corporation Prosthetic heart valve with reduced stitching
US10441421B2 (en) 2016-10-28 2019-10-15 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
FR3058631B1 (fr) * 2016-11-14 2019-01-25 Laboratoires Invalv Implant de traitement d'une valve biologique
US10973631B2 (en) 2016-11-17 2021-04-13 Edwards Lifesciences Corporation Crimping accessory device for a prosthetic valve
US10463484B2 (en) 2016-11-17 2019-11-05 Edwards Lifesciences Corporation Prosthetic heart valve having leaflet inflow below frame
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
WO2018102520A1 (en) 2016-12-02 2018-06-07 St. Jude Medical, Cardiology Division, Inc. Transcatheter delivery system with transverse wheel actuation
EP3547965A1 (en) 2016-12-02 2019-10-09 St. Jude Medical, Cardiology Division, Inc. Transcatheter delivery system with two modes of actuation
CN108245281A (zh) * 2016-12-28 2018-07-06 上海微创心通医疗科技有限公司 瓣膜假体
CN108261255B (zh) * 2016-12-30 2020-12-25 先健科技(深圳)有限公司 人工心脏瓣膜装置及其瓣叶和支架主体
US11185406B2 (en) * 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11013600B2 (en) 2017-01-23 2021-05-25 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11654023B2 (en) 2017-01-23 2023-05-23 Edwards Lifesciences Corporation Covered prosthetic heart valve
US10561495B2 (en) 2017-01-24 2020-02-18 4C Medical Technologies, Inc. Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve
CN110392557A (zh) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 心脏瓣膜模拟
USD867595S1 (en) 2017-02-01 2019-11-19 Edwards Lifesciences Corporation Stent
WO2018160790A1 (en) 2017-03-03 2018-09-07 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve design
WO2018170149A1 (en) * 2017-03-14 2018-09-20 Shape Memory Medical, Inc. Shape memory polymer foams to seal space around valves
WO2018184226A1 (zh) * 2017-04-07 2018-10-11 上海甲悦医疗器械有限公司 一种人工瓣膜及人工瓣膜植入方法
US10973634B2 (en) 2017-04-26 2021-04-13 Edwards Lifesciences Corporation Delivery apparatus for a prosthetic heart valve
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
US10842619B2 (en) 2017-05-12 2020-11-24 Edwards Lifesciences Corporation Prosthetic heart valve docking assembly
WO2018213091A1 (en) 2017-05-15 2018-11-22 St. Jude Medical, Cardiology Division, Inc. Transcatheter delivery system with wheel actuation
USD889653S1 (en) 2017-05-15 2020-07-07 St. Jude Medical, Cardiology Division, Inc. Stent having tapered struts
USD875250S1 (en) 2017-05-15 2020-02-11 St. Jude Medical, Cardiology Division, Inc. Stent having tapered aortic struts
USD875935S1 (en) 2017-05-15 2020-02-18 St. Jude Medical, Cardiology Division, Inc. Stent having tapered struts
US11135056B2 (en) 2017-05-15 2021-10-05 Edwards Lifesciences Corporation Devices and methods of commissure formation for prosthetic heart valve
EP3630013A4 (en) 2017-05-22 2020-06-17 Edwards Lifesciences Corporation VALVE ANCHORING DEVICE AND INSTALLATION METHOD
US11779238B2 (en) 2017-05-31 2023-10-10 Foundry Innovation & Research 1, Ltd. Implantable sensors for vascular monitoring
IL270865B1 (en) 2017-05-31 2024-01-01 Edwards Lifesciences Corp Sealing component for cardiac valve prosthesis
US11944495B2 (en) 2017-05-31 2024-04-02 Foundry Innovation & Research 1, Ltd. Implantable ultrasonic vascular sensor
US20210401571A9 (en) 2017-05-31 2021-12-30 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11026785B2 (en) 2017-06-05 2021-06-08 Edwards Lifesciences Corporation Mechanically expandable heart valve
US10869759B2 (en) 2017-06-05 2020-12-22 Edwards Lifesciences Corporation Mechanically expandable heart valve
CN107280806B (zh) * 2017-06-30 2023-06-23 中国人民解放军第二军医大学 一种尿道控尿器
CA3068313A1 (en) 2017-06-30 2019-01-03 Edwards Lifesciences Corporation Docking stations for transcatheter valves
JP7240338B2 (ja) * 2017-06-30 2023-03-15 オハイオ ステート イノベーション ファンデーション 経皮的弁置換手技で使用する３つの弁尖設計を有する人工心臓弁
CN110891526A (zh) 2017-06-30 2020-03-17 爱德华兹生命科学公司 用于经导管植入式设备的锁定和释放机构
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
WO2019014473A1 (en) 2017-07-13 2019-01-17 Tendyne Holdings, Inc. PROSTHETIC CARDIAC VALVES AND ASSOCIATED APPARATUS AND METHODS FOR IMPLEMENTING THE SAME
US10918473B2 (en) 2017-07-18 2021-02-16 Edwards Lifesciences Corporation Transcatheter heart valve storage container and crimping mechanism
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US11666444B2 (en) 2017-08-03 2023-06-06 The Regents Of The University Of California Atrial cage for placement, securing and anchoring of atrioventricular valves
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
KR102617878B1 (ko) 2017-08-11 2023-12-22 에드워즈 라이프사이언시스 코포레이션 인공 심장 판막용 밀봉 요소
US11083575B2 (en) 2017-08-14 2021-08-10 Edwards Lifesciences Corporation Heart valve frame design with non-uniform struts
US10932903B2 (en) 2017-08-15 2021-03-02 Edwards Lifesciences Corporation Skirt assembly for implantable prosthetic valve
US10898319B2 (en) 2017-08-17 2021-01-26 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10856971B2 (en) 2017-08-18 2020-12-08 Edwards Lifesciences Corporation Sealing members for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
USD890333S1 (en) 2017-08-21 2020-07-14 Edwards Lifesciences Corporation Heart valve docking coil
US10806573B2 (en) 2017-08-22 2020-10-20 Edwards Lifesciences Corporation Gear drive mechanism for heart valve delivery apparatus
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
JP7291124B2 (ja) 2017-08-28 2023-06-14 テンダイン ホールディングス，インコーポレイテッド テザー連結部を有する人工心臓弁
US10973629B2 (en) 2017-09-06 2021-04-13 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US20190069996A1 (en) 2017-09-07 2019-03-07 Edwards Lifesciences Corporation Integral flushing solution for blood stasis prevention in artificial heart valves
US11147667B2 (en) 2017-09-08 2021-10-19 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC SEALING DEVICE FOR USE AS A VASCULAR DUCT IMPLANT FOR REDUCING ENDOFUCTION
US10959842B2 (en) 2017-09-12 2021-03-30 W. L. Gore & Associates, Inc. Leaflet frame attachment for prosthetic valves
US10856972B2 (en) 2017-09-19 2020-12-08 Cardiovalve Ltd. Prosthetic valve with angularly offset atrial anchoring arms and ventricular anchoring legs
CA3155761A1 (en) 2017-09-27 2019-04-04 W.L. Gore & Associates, Inc. Prosthetic valves with mechanically coupled leaflets
CN111132636B (zh) 2017-09-27 2022-04-08 W.L.戈尔及同仁股份有限公司 带有可扩张框架的假体瓣膜以及相关系统和方法
CN116725739A (zh) 2017-10-13 2023-09-12 爱德华兹生命科学公司 叠套式假体瓣膜及递送系统
US11173023B2 (en) 2017-10-16 2021-11-16 W. L. Gore & Associates, Inc. Medical devices and anchors therefor
CN115177404A (zh) 2017-10-18 2022-10-14 爱德华兹生命科学公司 导管组合件
US11207499B2 (en) 2017-10-20 2021-12-28 Edwards Lifesciences Corporation Steerable catheter
CN111278387B (zh) 2017-10-23 2022-09-20 赛姆斯股份公司 人工瓣膜小叶
US11382751B2 (en) 2017-10-24 2022-07-12 St. Jude Medical, Cardiology Division, Inc. Self-expandable filler for mitigating paravalvular leak
CN116616959A (zh) 2017-10-31 2023-08-22 W.L.戈尔及同仁股份有限公司 经导管递送系统
CA3078608C (en) 2017-10-31 2023-03-28 W.L. Gore & Associates, Inc. Prosthetic heart valve
CA3205219A1 (en) 2017-10-31 2019-05-09 Edwards Lifesciences Corporation Medical valve and leaflet promoting tissue ingrowth
US11154397B2 (en) 2017-10-31 2021-10-26 W. L. Gore & Associates, Inc. Jacket for surgical heart valve
US10959843B2 (en) * 2017-11-12 2021-03-30 William Joseph Drasler Straddle annular mitral valve
CN109793596A (zh) 2017-11-17 2019-05-24 上海微创心通医疗科技有限公司 瓣膜支架、瓣膜假体和输送装置
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
CN109925094B (zh) * 2017-12-18 2021-06-25 先健科技(深圳)有限公司 人工心脏瓣膜
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
CR20200194A (es) 2018-01-23 2020-11-04 Edwards Lifesciences Corp Método para el estiramiento previo de materiales biocompatibles implantables y materiales y dispositivos producidos a medida
EP3720390A2 (en) 2018-01-25 2020-10-14 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
US11439732B2 (en) 2018-02-26 2022-09-13 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
CA3092153A1 (en) 2018-03-05 2019-09-12 Edwards Lifesciences Corporation Optical tissue measurement
US11590262B2 (en) 2018-03-09 2023-02-28 Tela Bio, Inc. Surgical repair graft
US11813413B2 (en) 2018-03-27 2023-11-14 St. Jude Medical, Cardiology Division, Inc. Radiopaque outer cuff for transcatheter valve
WO2019195860A2 (en) 2018-04-04 2019-10-10 Vdyne, Llc Devices and methods for anchoring transcatheter heart valve
EP3556323B1 (en) 2018-04-18 2023-07-19 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve
US11318011B2 (en) 2018-04-27 2022-05-03 Edwards Lifesciences Corporation Mechanically expandable heart valve with leaflet clamps
BR112020021003A2 (pt) 2018-04-30 2021-01-19 Edwards Lifesciences Corporation Dispositivos e métodos para frisar implantes protéticos
AU2018424859B2 (en) 2018-05-23 2024-04-04 Corcym S.R.L. A cardiac valve prosthesis
US11844914B2 (en) 2018-06-05 2023-12-19 Edwards Lifesciences Corporation Removable volume indicator for syringe
US10907123B2 (en) * 2018-07-10 2021-02-02 Trustees Of Boston University Sub-pascal unidirectional flow valves
RU187483U1 (ru) * 2018-07-12 2019-03-06 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний" (НИИ КПССЗ) Протез клапана сердца для малоинвазивной бесшовной имплантации
PL238191B1 (pl) * 2018-07-24 2021-07-19 American Heart Of Poland Spolka Akcyjna Niskoprofilowa, rozprężana na balonie sztuczna zastawka serca, zwłaszcza aortalna, implantowana przezskórnie
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
US11071627B2 (en) 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US11278437B2 (en) 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
WO2020060828A1 (en) 2018-09-20 2020-03-26 St. Jude Medical, Cardiology Division, Inc. Attachment of leaflets to prosthetic heart valve
US10595994B1 (en) 2018-09-20 2020-03-24 Vdyne, Llc Side-delivered transcatheter heart valve replacement
US11344413B2 (en) 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US10321995B1 (en) 2018-09-20 2019-06-18 Vdyne, Llc Orthogonally delivered transcatheter heart valve replacement
US11364117B2 (en) 2018-10-15 2022-06-21 St. Jude Medical, Cardiology Division, Inc. Braid connections for prosthetic heart valves
KR20210082188A (ko) 2018-10-19 2021-07-02 에드워즈 라이프사이언시스 코포레이션 비-원통형 프레임을 갖는 인공 심장 판막
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
KR20210086679A (ko) 2018-10-30 2021-07-08 에드워즈 라이프사이언시스 코포레이션 인공심장 판막의 판막 직경 및 힘 모니터링
JP2022509495A (ja) 2018-10-30 2022-01-20 エドワーズ ライフサイエンシーズ コーポレイション 人工弁送達アセンブリ
WO2020092205A1 (en) 2018-11-01 2020-05-07 Edwards Lifesciences Corporation Transcatheter pulmonic regenerative valve
USD926322S1 (en) 2018-11-07 2021-07-27 W. L. Gore & Associates, Inc. Heart valve cover
CA3118599A1 (en) 2018-11-08 2020-05-14 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CN113365578A (zh) 2018-12-06 2021-09-07 爱德华兹生命科学公司 可机械扩张的假体心脏瓣膜及递送装置
WO2020123267A1 (en) 2018-12-10 2020-06-18 St. Jude Medical, Cardiology Division, Inc. Prosthetic tricuspid valve replacement design
WO2020123230A1 (en) 2018-12-11 2020-06-18 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US10653522B1 (en) 2018-12-20 2020-05-19 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valve prosthesis
US11253359B2 (en) 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
US11273030B2 (en) 2018-12-26 2022-03-15 St. Jude Medical, Cardiology Division, Inc. Elevated outer cuff for reducing paravalvular leakage and increasing stent fatigue life
SG11202107448UA (en) 2019-01-16 2021-08-30 Edwards Lifesciences Corp Apparatus and method for monitoring valve expansion
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
US11185409B2 (en) 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
WO2020159783A1 (en) 2019-01-28 2020-08-06 Edwards Lifesciences Corporation Prosthetic valve
EP3920849A1 (en) 2019-02-04 2021-12-15 Medtronic, Inc. Balloon expandable frame for transcatheter implantation of a cardiac valve prosthesis
EP3923864A1 (en) 2019-02-13 2021-12-22 Edwards Lifesciences Corporation Heart valve frame design with non-uniform struts
US11497601B2 (en) 2019-03-01 2022-11-15 W. L. Gore & Associates, Inc. Telescoping prosthetic valve with retention element
WO2020181154A2 (en) 2019-03-05 2020-09-10 Vdyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
US10631983B1 (en) 2019-03-14 2020-04-28 Vdyne, Inc. Distal subannular anchoring tab for side-delivered transcatheter valve prosthesis
US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US10758346B1 (en) 2019-03-14 2020-09-01 Vdyne, Inc. A2 clip for side-delivered transcatheter mitral valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
AU2020240008A1 (en) 2019-03-18 2021-10-07 California Institute Of Technology Systems, devices, and methods relating to the manufacture of implantable prosthetic valves
CN113873973B (zh) 2019-03-26 2023-12-22 爱德华兹生命科学公司 假体心脏瓣膜
WO2020198283A1 (en) 2019-03-27 2020-10-01 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
WO2020198101A1 (en) 2019-03-27 2020-10-01 Edwards Lifesciences Corporation Delivery apparatus for a prosthetic valve
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CN110123490A (zh) * 2019-04-08 2019-08-16 北京佰仁医疗科技股份有限公司 一种支架和瓣叶的连接结构及应用该连接结构的介入肺动脉瓣和介入主动脉瓣
CN109984870A (zh) * 2019-04-08 2019-07-09 北京佰仁医疗科技股份有限公司 一种支架和瓣叶的连接结构及应用该连接结构的介入瓣中瓣和介入主动脉瓣
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
EP3952789A1 (en) 2019-04-11 2022-02-16 Edwards Lifesciences Corporation Method of assembling a prosthetic heart valve
JP2022530764A (ja) 2019-05-04 2022-07-01 ブイダイン，インコーポレイテッド 生来の弁輪での側方送達される人工心臓弁を展開するための締め付けデバイス及び方法
US11439504B2 (en) 2019-05-10 2022-09-13 Boston Scientific Scimed, Inc. Replacement heart valve with improved cusp washout and reduced loading
US11771554B2 (en) 2019-05-17 2023-10-03 Medtronic, Inc. Supra annular tapered balloon expandable stent for transcatheter implantation of a cardiac valve prosthesis
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
EP3975934A1 (en) 2019-05-29 2022-04-06 Edwards Lifesciences Corporation Prosthetic heart valve
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
WO2021003167A1 (en) 2019-07-02 2021-01-07 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus therefor
EP3993737A1 (en) 2019-07-03 2022-05-11 Edwards Lifesciences Corporation Force limiting mechanism for prosthetic heart valve delivery apparatus
EP4003230A1 (en) 2019-07-31 2022-06-01 St. Jude Medical, Cardiology Division, Inc. Alternate stent caf design for tavr
CN114222543A (zh) 2019-08-13 2022-03-22 爱德华兹生命科学公司 具有至少两种类型的支柱的假体心脏瓣膜
CA3152042A1 (en) 2019-08-20 2021-02-25 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
JP2022545728A (ja) 2019-08-26 2022-10-28 ブイダイン，インコーポレイテッド 側方送達可能な経カテーテル人工弁ならびにそれらを送達及び固定するための方法
CA3143293A1 (en) 2019-08-29 2021-03-04 Edwards Lifesciences Corporation Prosthetic heart valves
EP4034043A1 (en) 2019-09-27 2022-08-03 Edwards Lifesciences Corporation Modified prosthetic heart valve stent
WO2021086933A2 (en) 2019-10-30 2021-05-06 Edwards Lifesciences Corporation Prosthetic heart valve having locking feature
JP2023501846A (ja) 2019-10-30 2023-01-20 エドワーズ ライフサイエンシーズ コーポレイション 人工弁の直径推定のためのデバイスおよび方法
WO2021086611A1 (en) 2019-10-31 2021-05-06 Edwards Lifesciences Corporation Expandable transition element for a transcatheter delivery device
EP4051181A1 (en) 2019-10-31 2022-09-07 Edwards Lifesciences Corporation Real time measurements of physiological parameters associated with heart valve replacement
CN114430675A (zh) 2019-10-31 2022-05-03 爱德华兹生命科学公司 假体心脏瓣膜小叶组件和组装方法
EP4324428A3 (en) 2019-10-31 2024-04-17 Edwards Lifesciences Corporation Valves and delivery apparatuses equipped with optic fiber sensors
CA3143296A1 (en) 2019-11-06 2021-05-14 Edwards Lifesciences Corporation Skirt assembly for implantable prosthetic valve
EP3831343B1 (en) 2019-12-05 2024-01-31 Tendyne Holdings, Inc. Braided anchor for mitral valve
CN215914548U (zh) 2019-12-06 2022-03-01 爱德华兹生命科学公司 瓣膜监测组合件和瓣膜监测系统
AU2020396962A1 (en) 2019-12-06 2021-12-23 Edwards Lifesciences Corporation Flex sensors for measuring real-time valve diameter during procedure
WO2021113571A1 (en) 2019-12-06 2021-06-10 Edwards Lifesciences Corporation Prosthetic heart valve having non-linear struts
JP2023504327A (ja) 2019-12-06 2023-02-03 エドワーズ ライフサイエンシーズ コーポレイション 人工心臓弁用ベルト
JP2023504329A (ja) 2019-12-06 2023-02-03 エドワーズ ライフサイエンシーズ コーポレイション 交連部アセンブリ位置ロッキングのための交連部ポストの突出部を備えた人工心臓弁
CN114007548A (zh) 2019-12-06 2022-02-01 爱德华兹生命科学公司 用于植入假体心脏瓣膜的递送设备和方法
US11648114B2 (en) 2019-12-20 2023-05-16 Tendyne Holdings, Inc. Distally loaded sheath and loading funnel
US20230110800A1 (en) 2019-12-20 2023-04-13 W. L. Gore & Associates, Inc. Support structure for an implantable device with enhanced compressive stiffness region(s)
WO2021141888A1 (en) 2020-01-10 2021-07-15 Edwards Lifesciences Corporation Prosthetic heart valve leaflet assemblies and methods
CN115003255A (zh) 2020-01-10 2022-09-02 爱德华兹生命科学公司 假体心脏瓣膜小叶的组装方法
JP2023510856A (ja) 2020-01-13 2023-03-15 エドワーズ ライフサイエンシーズ コーポレイション 経カテーテル送達システムのためのハンドルロック機構
WO2021146111A1 (en) 2020-01-14 2021-07-22 Edwards Lifesciences Corporation Prosthetic heart valve leaflet assemblies and methods
EP4061284A1 (en) 2020-01-14 2022-09-28 Edwards Lifesciences Corporation Expansion and locking mechanism for mechanically expandable valves
US11234813B2 (en) 2020-01-17 2022-02-01 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery
US11931253B2 (en) 2020-01-31 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
WO2021158722A1 (en) 2020-02-06 2021-08-12 Edwards Lifesciences Corporation Prosthetic heart valve leaflet commissure assemblies and methods
AU2021224599A1 (en) 2020-02-18 2021-12-23 Edwards Lifesciences Corporation Apparatus for monitoring valve expansion
WO2021167819A1 (en) 2020-02-19 2021-08-26 Edwards Lifesciences Corporation Prosthetic heart valve
EP4084740A1 (en) 2020-02-24 2022-11-09 Edwards Lifesciences Corporation Hybrid frame for prosthetic heart valve
CN115426980A (zh) 2020-03-03 2022-12-02 爱德华兹生命科学公司 假体心脏瓣膜小叶连合部组合件和方法
US20210275298A1 (en) * 2020-03-04 2021-09-09 Medtronic, Inc. Balloon expandable stent with lengthened commissure posts for transcatheter implantation of a cardiac valve prosthesis
WO2021178276A1 (en) 2020-03-05 2021-09-10 Edwards Lifesciences Corporation Prosthetic heart valve leaflet assemblies and methods
KR20220150321A (ko) 2020-03-06 2022-11-10 에드워즈 라이프사이언시스 코포레이션 볼 조인트가 있는 노즈콘을 갖는 전달 장치
EP4103108A2 (en) 2020-03-17 2022-12-21 Edwards Lifesciences Corporation Modification of existing valvular structures for prosthetic heart valve implantation
CN115485426A (zh) 2020-03-18 2022-12-16 爱德华兹生命科学公司 纺织品、使用这种纺织品的可植入医疗设备以及制造这种纺织品的过程
EP4096579A1 (en) 2020-03-26 2022-12-07 Edwards Lifesciences Corporation Delivery apparatus for an implantable medical device
US11951002B2 (en) 2020-03-30 2024-04-09 Tendyne Holdings, Inc. Apparatus and methods for valve and tether fixation
CN115701954A (zh) 2020-04-01 2023-02-14 爱德华兹生命科学公司 用于可植入假体瓣膜的裙部组合件
WO2021216490A1 (en) 2020-04-21 2021-10-28 Edwards Lifesciences Corporation Loading apparatus for loading a prosthetic heart valve into a delivery apparatus
JP2023523998A (ja) 2020-04-28 2023-06-08 エドワーズ ライフサイエンシーズ コーポレイション 埋め込みシステムおよび埋め込みデバイスのための絹に基づいて静電紡糸された材料
WO2021225938A1 (en) 2020-05-04 2021-11-11 Edwards Lifesciences Corporation Leaflet attachment in prosthetic heart valves using buckle commissure clamps
CN218187031U (zh) 2020-05-14 2023-01-03 爱德华兹生命科学公司 假体心脏瓣膜
CN113662711A (zh) 2020-05-15 2021-11-19 爱德华兹生命科学公司 假体心脏瓣膜小叶连合部组件和方法
JP2023527402A (ja) 2020-05-28 2023-06-28 エドワーズ ライフサイエンシーズ コーポレイション 弁尖の折り畳みまたは捕獲のための方法およびデバイス
EP4157151A1 (en) 2020-05-29 2023-04-05 Edwards Lifesciences Corporation Delivery apparatus and methods for implanting prosthetic heart valves
JP2023529424A (ja) 2020-06-08 2023-07-10 エドワーズ ライフサイエンシーズ コーポレイション プロテーゼ医療デバイスのための送達装置のためのカプセル
CN113768661A (zh) 2020-06-10 2021-12-10 爱德华兹生命科学公司 用于植入式医疗装置的递送设备的释放机构
EP4161445A1 (en) 2020-07-09 2023-04-12 Edwards Lifesciences Corporation Mechanically expandable prosthetic device
EP4161444A1 (en) 2020-07-10 2023-04-12 Edwards Lifesciences Corporation Prosthetic heart valves with expansion and locking assemblies
CN216570344U (zh) 2020-07-10 2022-05-24 爱德华兹生命科学公司 假体瓣膜
WO2022015683A1 (en) 2020-07-13 2022-01-20 Edwards Lifesciences Corporation Clamps for coupling expansion and locking assemblies to frames of prosthetic valves
CN113940788A (zh) 2020-07-15 2022-01-18 爱德华兹生命科学公司 用于调节安装在假体瓣膜内的小叶的张力的装置和方法
CN216652564U (zh) 2020-07-16 2022-06-03 爱德华兹生命科学公司 假体瓣膜和递送组件
EP4181829A1 (en) 2020-07-17 2023-05-24 Edwards Lifesciences Corporation Commissure assemblies formed from tabs of asymmetric leaflets
CN115989008A (zh) 2020-07-21 2023-04-18 爱德华兹生命科学公司 具有h形连合窗的假体心脏瓣膜及其组装方法
CN115916274A (zh) 2020-07-22 2023-04-04 爱德华兹生命科学公司 防污可植入材料及制作方法
US11730590B2 (en) * 2020-07-23 2023-08-22 St. Jude Medical, Cardiology Division, Inc. Low profile expandable heart valve
EP4178490A1 (en) 2020-08-12 2023-05-17 Edwards Lifesciences Corporation Prosthetic heart valve
EP4181831A1 (en) 2020-08-18 2023-05-24 Edwards Lifesciences Corporation Prosthetic heart valve including an expansion and locking mechanism transitionable between locked and unlocked states
WO2022039853A1 (en) 2020-08-19 2022-02-24 Tendyne Holdings, Inc. Fully-transseptal apical pad with pulley for tensioning
EP4204063A1 (en) 2020-08-25 2023-07-05 Edwards Lifesciences Corporation Medical balloon sensing assembly
CN111938872A (zh) * 2020-09-04 2020-11-17 上海纽脉医疗科技有限公司 介入式瓣架以及主动脉瓣膜
WO2022056048A1 (en) 2020-09-09 2022-03-17 Edwards Lifesciences Corporation Tapered prosthetic heart valves with valvular structures forming tapered flow channels
CN114305797A (zh) 2020-09-30 2022-04-12 爱德华兹生命科学公司 假体心脏瓣膜小叶组合件和方法
WO2022072564A1 (en) 2020-09-30 2022-04-07 Edwards Lifesciences Corporation Delivery apparatus for mechanically expandable valve
WO2022076508A1 (en) 2020-10-06 2022-04-14 Edwards Lifesciences Corporation Protective covers for prosthetic valves
EP4225212A1 (en) 2020-10-06 2023-08-16 Edwards Lifesciences Corporation Commissure locking member
WO2022086931A1 (en) 2020-10-20 2022-04-28 Edwards Lifesciences Corporation Sound and vibration sensors for estimating prosthetic valve diameter during expansion
CA3199434A1 (en) 2020-10-28 2022-05-05 Edwards Lifesciences Corporation Systems and methods for estimating outer diameters of prosthetic valves
WO2022094456A1 (en) 2020-11-02 2022-05-05 Edwards Lifesciences Corporation Delivery apparatus for prosthetic implants
WO2022103747A1 (en) 2020-11-10 2022-05-19 Edwards Lifesciences Corporation Prosthetic heart valves with hermetic layers or valvular structures to reduce thrombosis risk
WO2022103794A1 (en) 2020-11-11 2022-05-19 Edwards Lifesciences Corporation Transcatheter delivery apparatus
EP4243734A1 (en) 2020-11-12 2023-09-20 Edwards Lifesciences Corporation Prosthetic heart valve leaflet assemblies and methods
EP4277573A1 (en) 2021-01-14 2023-11-22 Edwards Lifesciences Corporation Implantable medical devices
CN217390969U (zh) 2021-01-20 2022-09-09 爱德华兹生命科学公司 可机械扩展的双腔静脉对接装置
WO2022159809A1 (en) 2021-01-25 2022-07-28 Edwards Lifesciences Corporation Mechanically expandable heart valves with several types of interconnected struts
EP4301278A1 (en) * 2021-03-01 2024-01-10 Medtronic, Inc. Implant tissue protection tool
CN220512957U (zh) 2021-04-07 2024-02-23 爱德华兹生命科学公司 可植入医疗装置
CN115227448A (zh) 2021-04-22 2022-10-25 爱德华兹生命科学公司 具有齿合锁定机构的假体心脏瓣膜及其制造和使用方法
WO2022251577A1 (en) 2021-05-28 2022-12-01 Edwards Lifesciences Corporation Mechanically-expandable prosthetic heart valves, delivery apparatus, and methods
EP4346701A1 (en) 2021-06-03 2024-04-10 Edwards Lifesciences Corporation Skirt for prosthetic heart valve
CA3220922A1 (en) 2021-06-07 2022-12-15 Edwards Lifesciences Corporation Leaflets and leaflet separators for prosthetic valves
EP4351478A1 (en) 2021-06-11 2024-04-17 Edwards Lifesciences Corporation Prosthetic heart valve
CN115475031A (zh) 2021-06-15 2022-12-16 爱德华兹生命科学公司 人工瓣膜组件
WO2022266119A1 (en) 2021-06-16 2022-12-22 Edwards Lifesciences Corporation Multifunctional sealing member for improved endothelialization and paravalvular leakage
WO2022266422A1 (en) 2021-06-18 2022-12-22 Edwards Lifesciences Corporation Hybrid frame for prosthetic heart valve
CN117858681A (zh) 2021-07-22 2024-04-09 爱德华兹生命科学公司 假体心脏瓣膜
WO2023014555A1 (en) 2021-08-03 2023-02-09 Edwards Lifesciences Corporation Prosthetic valves with mechanisms for controlled expansion
WO2023018521A1 (en) 2021-08-11 2023-02-16 Edwards Lifesciences Corporation Mechanically-expandable prosthetic heart valve
WO2023038879A1 (en) 2021-09-07 2023-03-16 Edwards Lifesciences Corporation Textiles, methods of making same and medical devices using the same
US11911274B2 (en) * 2021-10-27 2024-02-27 Joon Bu Park Artificial heart valves incorporating negative poisson's ratio materials
WO2023086650A1 (en) 2021-11-15 2023-05-19 Edwards Lifesciences Corporation Prosthetic valves with wider outflow cells
WO2023091419A1 (en) 2021-11-16 2023-05-25 Edwards Lifesciences Corporation Device for folding valve leaflets
WO2023091344A1 (en) 2021-11-16 2023-05-25 Edwards Lifesciences Corporation Prosthetic heart valve
WO2023091422A1 (en) 2021-11-17 2023-05-25 Edwards Lifesciences Corporation Prosthetic valve delivery apparatus with strain relief nosecone
WO2023137000A1 (en) 2022-01-11 2023-07-20 Edwards Lifesciences Corporation Prosthetic heart valve
WO2023137076A1 (en) 2022-01-11 2023-07-20 Edwards Lifesciences Corporation Mechanically-expandable prosthetic valve
WO2023150262A1 (en) 2022-02-03 2023-08-10 Edwards Lifesciences Corporation Prosthetic valve having laminated skirt assembly with reduced overall thickness and increased stretchability
WO2023158594A1 (en) 2022-02-15 2023-08-24 Edwards Lifesciences Corporation Locking mechanism for a mechanically expandable prosthetic valve
WO2023183441A1 (en) 2022-03-23 2023-09-28 Edwards Lifesciences Corporation Prosthetic valves with valvular structures retained between two frames
WO2023192411A1 (en) 2022-03-30 2023-10-05 Edwards Lifesciences Corporation Delivery apparatus for mechanically expandable valve
WO2023224897A1 (en) * 2022-05-16 2023-11-23 Edwards Lifesciences Corporation Outer skirt for an expandable prosthetic heart valve
US20230372084A1 (en) 2022-05-18 2023-11-23 St. Jude Medical, Cardiology Division, Inc. Active Edge Protection for Balloon Expandable Valve
US20230372097A1 (en) 2022-05-18 2023-11-23 St. Jude Medical, Cardiology Division, Inc. Automated Balloon Inflation Device for Transcatheter Heart Valve Implantation
US20230372096A1 (en) 2022-05-18 2023-11-23 St. Jude Medical, Cardiology Division, Inc. Paravalvular Leak Protection for Balloon Expandable Valves
WO2023225236A1 (en) * 2022-05-19 2023-11-23 Edwards Lifesciences Corporation Prosthetic valve with rungs of support members
US20230390056A1 (en) 2022-06-06 2023-12-07 St. Jude Medical, Cardiology Division, Inc. Balloon Expandable Valve Securement Aids
US20230390055A1 (en) 2022-06-06 2023-12-07 St. Jude Medical, Cardiology Division, Inc. Balloon Expandable Leaflet Protection During Crimping
WO2024006230A1 (en) 2022-06-27 2024-01-04 Edwards Lifesciences Corporation Leaflet perforation tools and associated methods
WO2024018335A1 (en) * 2022-07-19 2024-01-25 Medtronic, Inc. Prosthetic heart valves having leaflet protection
WO2024020181A1 (en) 2022-07-22 2024-01-25 Edwards Lifesciences Corporation Prosthetic heart valves and prosthetic heart valve delivery assemblies
US20240033078A1 (en) 2022-07-26 2024-02-01 St. Jude Medical, Cardiology Division, Inc. Stretchable Member Transcatheter Valve
WO2024025897A1 (en) 2022-07-27 2024-02-01 Edwards Lifesciences Corporation Balloon assemblies with inflatable toroid balloons
WO2024030290A1 (en) 2022-08-01 2024-02-08 Edwards Lifesciences Corporation Inflatable balloons with flow channels
WO2024044177A1 (en) 2022-08-23 2024-02-29 Edwards Lifesciences Corporation Prosthetic valve
WO2024050043A1 (en) 2022-09-02 2024-03-07 Edwards Lifesciences Corporation Prosthetic valves with non-uniform valvular structures
WO2024059281A1 (en) * 2022-09-15 2024-03-21 Vascudyne, Inc. Improved valve incorporating constructed tissue
WO2024059254A1 (en) 2022-09-16 2024-03-21 Edwards Lifesciences Corporation Capsule loading assist apparatuses and associated methods

Family Cites Families (459)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8000A (en) * 1851-03-25 Improvement in scythe-fastenings
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
US3587115A (en) 1966-05-04 1971-06-28 Donald P Shiley Prosthetic sutureless heart valves and implant tools therefor
US3548417A (en) 1967-09-05 1970-12-22 Ronnie G Kischer Heart valve having a flexible wall which rotates between open and closed positions
US3534411A (en) 1967-10-05 1970-10-20 Donald P Shiley Cloth covered heart valve
US3551913A (en) 1968-04-02 1971-01-05 Donald P Shiley Heart valve prosthesis with guard structure
GB1268484A (en) 1968-06-28 1972-03-29 Brian John Bellhouse Improvements relating to non-return valves particularly as prosthetics
USRE30912E (en) 1968-09-16 1982-04-27 Hancock Laboratories, Inc. Stent for heart valve
US3570014A (en) 1968-09-16 1971-03-16 Warren D Hancock Stent for heart valve
JPS4940999Y1 (zh) * 1969-05-31 1974-11-11
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3714671A (en) 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3848578A (en) 1971-01-04 1974-11-19 Investors In Ventures Inc Valve with means for promoting ingrowth of tissue
US3755823A (en) 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
GB1402255A (en) 1971-09-24 1975-08-06 Smiths Industries Ltd Medical or surgical devices of the kind having an inflatable balloon
US3818511A (en) 1972-11-17 1974-06-25 Medical Prod Corp Medical prosthesis for ducts or conduits
US3983581A (en) 1975-01-20 1976-10-05 William W. Angell Heart valve stent
US4192020A (en) 1975-05-07 1980-03-11 Washington University Heart valve prosthesis
US4173606A (en) 1975-07-14 1979-11-06 Ceskoslovenska Akademie Ved. Method of manufacturing shaped articles from crystalline acrylonitrile polymers and copolymers
US4035849A (en) 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
CA1069652A (en) 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4084268A (en) * 1976-04-22 1978-04-18 Shiley Laboratories, Incorporated Prosthetic tissue heart valve
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4297749A (en) 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4265694A (en) 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4222126A (en) 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4574803A (en) 1979-01-19 1986-03-11 Karl Storz Tissue cutter
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4373216A (en) 1980-10-27 1983-02-15 Hemex, Inc. Heart valves having edge-guided occluders
US4388735A (en) 1980-11-03 1983-06-21 Shiley Inc. Low profile prosthetic xenograft heart valve
US4339831A (en) 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4470157A (en) 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4345340A (en) 1981-05-07 1982-08-24 Vascor, Inc. Stent for mitral/tricuspid heart valve
US4501030A (en) 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4406022A (en) 1981-11-16 1983-09-27 Kathryn Roy Prosthetic valve means for cardiovascular surgery
SE445884B (sv) 1982-04-30 1986-07-28 Medinvent Sa Anordning for implantation av en rorformig protes
IT1212547B (it) 1982-08-09 1989-11-30 Iorio Domenico Strumento di impiego chirurgico destinato a rendere piu' facili e piu' sicuri gli interventi per l'impianto di bioprotesi in organi umani
US4477930A (en) 1982-09-28 1984-10-23 Mitral Medical International, Inc. Natural tissue heat valve and method of making same
GB8300636D0 (en) 1983-01-11 1983-02-09 Black M M Heart valve replacements
US4506394A (en) 1983-01-13 1985-03-26 Molrose Management, Ltd. Cardiac valve prosthesis holder
US4535483A (en) 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
US4612011A (en) 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
US4585705A (en) 1983-11-09 1986-04-29 Dow Corning Corporation Hard organopolysiloxane release coating
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4627436A (en) 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
US4592340A (en) 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US5007896A (en) 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
US4883458A (en) 1987-02-24 1989-11-28 Surgical Systems & Instruments, Inc. Atherectomy system and method of using the same
DE3426300A1 (de) 1984-07-17 1986-01-30 Doguhan Dr.med. 6000 Frankfurt Baykut Zweiwegeventil und seine verwendung als herzklappenprothese
US4662890A (en) 1984-10-09 1987-05-05 Waters Instruments, Inc. Tubular medical prosthesis
DE3442088A1 (de) 1984-11-17 1986-05-28 Beiersdorf Ag, 2000 Hamburg Herzklappenprothese
SU1271508A1 (ru) 1984-11-29 1986-11-23 Горьковский государственный медицинский институт им.С.М.Кирова Искусственный клапан сердца
US4759758A (en) 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
FR2587614B1 (fr) 1985-09-23 1988-01-15 Biomasys Sa Valve cardiaque prothetique
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
DE3640745A1 (de) 1985-11-30 1987-06-04 Ernst Peter Prof Dr M Strecker Katheter zum herstellen oder erweitern von verbindungen zu oder zwischen koerperhohlraeumen
CH672247A5 (zh) 1986-03-06 1989-11-15 Mo Vysshee Tekhnicheskoe Uchil
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US4762128A (en) 1986-12-09 1988-08-09 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US4796629A (en) 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4829990A (en) 1987-06-25 1989-05-16 Thueroff Joachim Implantable hydraulic penile erector
US4851001A (en) 1987-09-17 1989-07-25 Taheri Syde A Prosthetic valve for a blood vein and an associated method of implantation of the valve
US5266073A (en) 1987-12-08 1993-11-30 Wall W Henry Angioplasty stent
US5147399A (en) 1988-02-01 1992-09-15 Dellon Arnold L Method of treating nerve defects through use of a bioabsorbable surgical device
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
DE8815082U1 (zh) 1988-11-29 1989-05-18 Biotronik Mess- Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin, 1000 Berlin, De
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4966604A (en) 1989-01-23 1990-10-30 Interventional Technologies Inc. Expandable atherectomy cutter with flexibly bowed blades
US5425739A (en) 1989-03-09 1995-06-20 Avatar Design And Development, Inc. Anastomosis stent and stent selection system
US4994077A (en) 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
DK0474748T3 (da) 1989-05-31 1995-05-01 Baxter Int Biologisk klapprotese
US5609626A (en) 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5047041A (en) 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US4986830A (en) 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5089015A (en) 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5591185A (en) 1989-12-14 1997-01-07 Corneal Contouring Development L.L.C. Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping
US5037434A (en) 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5059177A (en) 1990-04-19 1991-10-22 Cordis Corporation Triple lumen balloon catheter
DK124690D0 (da) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
US5085635A (en) 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5139515A (en) 1990-08-15 1992-08-18 Francis Robicsek Ascending aortic prosthesis
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5755782A (en) * 1991-01-24 1998-05-26 Autogenics Stents for autologous tissue heart valve
US5282847A (en) 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
JPH05184611A (ja) 1991-03-19 1993-07-27 Kenji Kusuhara 弁輪支持器具及びその取り付け方法
US5295958A (en) 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5167628A (en) 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
PL167854B1 (en) * 1991-05-08 1995-11-30 Nika Health Products Ltd Method of covering valvule prosthesis base with textile material and apparatus therefor
US5397351A (en) 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
IT1245750B (it) 1991-05-24 1994-10-14 Sorin Biomedica Emodialisi S R Protesi valvolare cardiaca, particolarmente per sostituzione della valvola aortica
US5584803A (en) 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5558644A (en) 1991-07-16 1996-09-24 Heartport, Inc. Retrograde delivery catheter and method for inducing cardioplegic arrest
US5769812A (en) 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5192297A (en) 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US5756476A (en) 1992-01-14 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell proliferation using antisense oligonucleotides
US5489297A (en) 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5163953A (en) 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
US5258023A (en) 1992-02-12 1993-11-02 Reger Medical Development, Inc. Prosthetic heart valve
US5683448A (en) 1992-02-21 1997-11-04 Boston Scientific Technology, Inc. Intraluminal stent and graft
SE511582C2 (sv) * 1992-03-13 1999-10-25 Jcl Technic Ab Hjärtventil, s.k. hjärtklaff
US5628792A (en) 1992-03-13 1997-05-13 Jcl Technic Ab Cardiac valve with recessed valve flap hinges
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
DE4327825C2 (de) 1992-11-24 1996-10-02 Mannesmann Ag Drosselrückschlagelement
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
GB9312666D0 (en) 1993-06-18 1993-08-04 Vesely Ivan Bioprostetic heart valve
CA2125258C (en) 1993-08-05 1998-12-22 Dinah B Quiachon Multicapsule intraluminal grafting system and method
US5411522A (en) 1993-08-25 1995-05-02 Linvatec Corporation Unitary anchor for soft tissue fixation
US5545209A (en) 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US5480424A (en) 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
ES2157918T3 (es) * 1993-12-14 2001-09-01 Sante Camilli Una valvula percutanea implantable para su uso en vasos sanguineos.
DE4401227C2 (de) 1994-01-18 1999-03-18 Ernst Peter Prof Dr M Strecker In den Körper eines Patienten perkutan implantierbare Endoprothese
US5476506A (en) 1994-02-08 1995-12-19 Ethicon, Inc. Bi-directional crimped graft
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5728068A (en) 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5522881A (en) 1994-06-28 1996-06-04 Meadox Medicals, Inc. Implantable tubular prosthesis having integral cuffs
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US6331188B1 (en) 1994-08-31 2001-12-18 Gore Enterprise Holdings, Inc. Exterior supported self-expanding stent-graft
US5562727A (en) 1994-10-07 1996-10-08 Aeroquip Corporation Intraluminal graft and method for insertion thereof
NL9500147A (nl) 1995-01-26 1996-09-02 Industrial Res Bv Werkwijze voor het uit foliemateriaal vervaardigen van een hulsvormige stent, en stent verkregen onder toepassing van deze werkwijze.
US5681345A (en) 1995-03-01 1997-10-28 Scimed Life Systems, Inc. Sleeve carrying stent
US5639274A (en) 1995-06-02 1997-06-17 Fischell; Robert E. Integrated catheter system for balloon angioplasty and stent delivery
US5716417A (en) 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
DE19532846A1 (de) 1995-09-06 1997-03-13 Georg Dr Berg Ventileinrichtung
US5769882A (en) 1995-09-08 1998-06-23 Medtronic, Inc. Methods and apparatus for conformably sealing prostheses within body lumens
US5591195A (en) 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
US5665117A (en) 1995-11-27 1997-09-09 Rhodes; Valentine J. Endovascular prosthesis with improved sealing means for aneurysmal arterial disease and method of use
DE19546692C2 (de) 1995-12-14 2002-11-07 Hans-Reiner Figulla Selbstexpandierende Herzklappenprothese zur Implantation im menschlichen Körper über ein Kathetersystem
FR2742994B1 (fr) 1995-12-28 1998-04-03 Sgro Jean-Claude Ensemble de traitement chirurgical d'une lumiere intracorporelle
US5855602A (en) 1996-09-09 1999-01-05 Shelhigh, Inc. Heart valve prosthesis
US5843158A (en) 1996-01-05 1998-12-01 Medtronic, Inc. Limited expansion endoluminal prostheses and methods for their use
US5804598A (en) 1996-03-21 1998-09-08 Rockhurst University Xylomollin derivatives for use as insect feeding deterrents
US5843160A (en) 1996-04-01 1998-12-01 Rhodes; Valentine J. Prostheses for aneurysmal and/or occlusive disease at a bifurcation in a vessel, duct, or lumen
DE69719237T2 (de) 1996-05-23 2003-11-27 Samsung Electronics Co Ltd Flexibler, selbstexpandierbarer Stent und Verfahren zu dessen Herstellung
US5891195A (en) 1996-05-24 1999-04-06 Sulzer Carbomedics Inc. Combined prosthetic aortic heart valve and vascular graft with sealed sewing ring
US5733326A (en) * 1996-05-28 1998-03-31 Cordis Corporation Composite material endoprosthesis
EP0909148A1 (en) 1996-05-31 1999-04-21 The University Of Western Ontario Expansible bioprosthetic valve stent
US6007544A (en) 1996-06-14 1999-12-28 Beth Israel Deaconess Medical Center Catheter apparatus having an improved shape-memory alloy cuff and inflatable on-demand balloon for creating a bypass graft in-vivo
US5855601A (en) 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5741326A (en) 1996-07-15 1998-04-21 Cordis Corporation Low profile thermally set wrapped cover for a percutaneously deployed stent
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US6217585B1 (en) 1996-08-16 2001-04-17 Converge Medical, Inc. Mechanical stent and graft delivery system
AU5355598A (en) 1996-11-07 1998-06-10 Medtronic Instent, Inc. Variable flexibility stent
US6010529A (en) 1996-12-03 2000-01-04 Atrium Medical Corporation Expandable shielded vessel support
US5749890A (en) 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
NL1004827C2 (nl) 1996-12-18 1998-06-19 Surgical Innovations Vof Inrichting voor het reguleren van de bloedsomloop.
US6015431A (en) 1996-12-23 2000-01-18 Prograft Medical, Inc. Endolumenal stent-graft with leak-resistant seal
US6551350B1 (en) 1996-12-23 2003-04-22 Gore Enterprise Holdings, Inc. Kink resistant bifurcated prosthesis
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
GB9701479D0 (en) 1997-01-24 1997-03-12 Aortech Europ Ltd Heart valve
US5853419A (en) * 1997-03-17 1998-12-29 Surface Genesis, Inc. Stent
US6096071A (en) 1998-03-26 2000-08-01 Yadav; Jay S. Ostial stent
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
US5855597A (en) 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US6258120B1 (en) 1997-12-23 2001-07-10 Embol-X, Inc. Implantable cerebral protection device and methods of use
US6056762A (en) 1997-05-22 2000-05-02 Kensey Nash Corporation Anastomosis system and method of use
US5944750A (en) 1997-06-30 1999-08-31 Eva Corporation Method and apparatus for the surgical repair of aneurysms
US6167605B1 (en) 1997-09-12 2001-01-02 Advanced Cardiovascular Systems, Inc. Collet type crimping tool
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6769161B2 (en) 1997-10-16 2004-08-03 Scimed Life Systems, Inc. Radial stent crimper
US5910170A (en) 1997-12-17 1999-06-08 St. Jude Medical, Inc. Prosthetic heart valve stent utilizing mounting clips
EP1049425B1 (en) 1997-12-29 2009-11-25 Cleveland Clinic Foundation The System for minimally invasive insertion of a bioprosthetic heart valve
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
US6395019B2 (en) 1998-02-09 2002-05-28 Trivascular, Inc. Endovascular graft
US6451396B1 (en) * 1998-02-13 2002-09-17 Gore Enterprise Holdings, Inc. Flexure endurant composite elastomer compositions
EP0935978A1 (en) 1998-02-16 1999-08-18 Medicorp S.A. Angioplasty and stent delivery catheter
US6174327B1 (en) 1998-02-27 2001-01-16 Scimed Life Systems, Inc. Stent deployment apparatus and method
US5938697A (en) 1998-03-04 1999-08-17 Scimed Life Systems, Inc. Stent having variable properties
EP0943300A1 (en) 1998-03-17 1999-09-22 Medicorp S.A. Reversible action endoprosthesis delivery device.
WO1999049927A1 (fr) 1998-03-27 1999-10-07 Kanji Inoue Dispositif pour transplantation
US7500988B1 (en) 2000-11-16 2009-03-10 Cordis Corporation Stent for use in a stent graft
US6254636B1 (en) 1998-06-26 2001-07-03 St. Jude Medical, Inc. Single suture biological tissue aortic stentless valve
US6159656A (en) 1998-06-26 2000-12-12 Fuji Photo Film Co., Ltd. Positive photosensitive resin
US6527979B2 (en) 1999-08-27 2003-03-04 Corazon Technologies, Inc. Catheter systems and methods for their use in the treatment of calcified vascular occlusions
US6306163B1 (en) 1998-08-04 2001-10-23 Advanced Cardiovascular Systems, Inc. Assembly for collecting emboli and method of use
US6334873B1 (en) * 1998-09-28 2002-01-01 Autogenics Heart valve having tissue retention with anchors and an outer sheath
US6368345B1 (en) 1998-09-30 2002-04-09 Edwards Lifesciences Corporation Methods and apparatus for intraluminal placement of a bifurcated intraluminal garafat
DE19857887B4 (de) 1998-12-15 2005-05-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerungsstütze für eine Herzklappenprothese
SG76636A1 (en) 1998-12-22 2000-11-21 Medinol Ltd Apparatus and method for securing a stent on a balloon
FR2788217A1 (fr) 1999-01-12 2000-07-13 Brice Letac Valvule prothetique implantable par catheterisme, ou chirurgicalement
US6350277B1 (en) 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
EP1143882B1 (en) * 1999-01-26 2007-12-05 Edwards Lifesciences Corporation Flexible heart valve
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
US6193727B1 (en) 1999-02-05 2001-02-27 Advanced Cardiovascular Systems, Inc. System for removably securing a stent on a catheter assembly and method of use
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
DE19907646A1 (de) 1999-02-23 2000-08-24 Georg Berg Ventileinrichtung zum Einsetzen in ein Hohlorgan
US6210408B1 (en) 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
US6287335B1 (en) 1999-04-26 2001-09-11 William J. Drasler Intravascular folded tubular endoprosthesis
BR0010096A (pt) * 1999-04-28 2002-02-19 St Jude Medical Prótese valvular cardìaca, kit, processo para ligar uma prótese valvular cardìaca em um paciente, e, aplicador prendedor para implantar uma prótese valvular cardìaca
DE69909331T2 (de) * 1999-05-10 2004-05-27 THE SECRETARY OF STATE FOR DEFENCE Whitehall Intelligenter poröser film oder intelligentes poröses material
US6309417B1 (en) 1999-05-12 2001-10-30 Paul A. Spence Heart valve and apparatus for replacement thereof
EP1057460A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Replacement valve assembly and method of implanting same
US7628803B2 (en) 2001-02-05 2009-12-08 Cook Incorporated Implantable vascular device
US6299638B1 (en) 1999-06-10 2001-10-09 Sulzer Carbomedics Inc. Method of attachment of large-bore aortic graft to an aortic valve
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US6352547B1 (en) 1999-09-22 2002-03-05 Scimed Life Systems, Inc. Stent crimping system
IT1307268B1 (it) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa Dispositivo per interventi di riparazione o sostituzione valvolarecardiaca.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
FR2815844B1 (fr) 2000-10-31 2003-01-17 Jacques Seguin Support tubulaire de mise en place, par voie percutanee, d'une valve cardiaque de remplacement
FR2800984B1 (fr) 1999-11-17 2001-12-14 Jacques Seguin Dispositif de remplacement d'une valve cardiaque par voie percutanee
US7018406B2 (en) * 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
DE19955490A1 (de) 1999-11-18 2001-06-13 Thermamed Gmbh Medizintechnische Wärmevorrichtung
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
NZ520462A (en) * 2000-01-27 2004-08-27 3F Therapeutics Inc Prosthetic heart valve
PL211860B1 (pl) 2000-01-31 2012-07-31 Cook Biotech Inc Zespół zastawki stentu
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
ATE255860T1 (de) 2000-03-03 2003-12-15 Cook Inc Endovaskuläre vorrichtung mit stent
ATE331487T1 (de) 2000-03-09 2006-07-15 Design & Performance Cyprus Lt Stent mit hüllenbefestigungen
US6695875B2 (en) 2000-03-14 2004-02-24 Cook Incorporated Endovascular stent graft
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
WO2001087575A2 (en) 2000-05-12 2001-11-22 The Regents Of The University Of Michigan Reverse fabrication of porous materials
US6773454B2 (en) 2000-08-02 2004-08-10 Michael H. Wholey Tapered endovascular stent graft and method of treating abdominal aortic aneurysms and distal iliac aneurysms
WO2002022054A1 (en) 2000-09-12 2002-03-21 Gabbay S Valvular prosthesis and method of using same
US7510572B2 (en) 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
DE10047614C2 (de) 2000-09-26 2003-03-27 Generis Gmbh Vorrichtung zum schichtweisen Aufbau von Modellen
DE10049813C1 (de) 2000-10-09 2002-04-18 Universitaetsklinikum Freiburg Vorrichtung zum lokalen Abtrag einer Aortenklappe am menschlichen oder tierischen Herz
DE10049814B4 (de) 2000-10-09 2006-10-19 Universitätsklinikum Freiburg Vorrichtung zur Unterstützung chirurgischer Maßnahmen innerhalb eines Gefäßes, insbesondere zur minimalinvasiven Explantation und Implantation von Herzklappen
DE10049812B4 (de) 2000-10-09 2004-06-03 Universitätsklinikum Freiburg Vorrichtung zum Ausfiltern makroskopischer Teilchen aus der Blutbahn beim lokalen Abtrag einer Aortenklappe am menschlichen oder tierischen Herz
DE10049815B4 (de) 2000-10-09 2005-10-13 Universitätsklinikum Freiburg Vorrichtung zum lokalen Abtrag einer Aortenklappe am menschlichen oder tierischen Herz
AU2001218090A1 (en) 2000-10-31 2002-05-21 East Carolina University Tissue lockable connecting structures
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US7267685B2 (en) 2000-11-16 2007-09-11 Cordis Corporation Bilateral extension prosthesis and method of delivery
ES2247198T3 (es) 2000-11-21 2006-03-01 Rex Medical, Lp Valvula aortica percutanea.
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
ES2253325T3 (es) 2000-12-15 2006-06-01 ANGIOMED GMBH & CO. MEDIZINTECHNIK KG Protesis endovascular con valvula.
US6716244B2 (en) * 2000-12-20 2004-04-06 Carbomedics, Inc. Sewing cuff assembly for heart valves
US6468660B2 (en) 2000-12-29 2002-10-22 St. Jude Medical, Inc. Biocompatible adhesives
US6783542B2 (en) 2001-02-22 2004-08-31 Scimed Life Systems, Inc Crimpable balloon/stent protector
US6585761B2 (en) 2001-03-01 2003-07-01 Syde A. Taheri Prosthetic vein valve and method
US6488704B1 (en) 2001-05-07 2002-12-03 Biomed Solutions, Llc Implantable particle measuring apparatus
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US6773456B1 (en) 2001-03-23 2004-08-10 Endovascular Technologies, Inc. Adjustable customized endovascular graft
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
DE60209583T2 (de) * 2001-03-30 2006-12-21 Terumo K.K. Stent
WO2002087474A1 (en) * 2001-05-01 2002-11-07 Imperial Medical Devices Limited Valve prosthesis
US6936067B2 (en) * 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent
KR100393548B1 (ko) * 2001-06-05 2003-08-02 주식회사 엠아이텍 의료용 스텐트
US7510571B2 (en) 2001-06-11 2009-03-31 Boston Scientific, Scimed, Inc. Pleated composite ePTFE/textile hybrid covering
US6994722B2 (en) 2001-07-03 2006-02-07 Scimed Life Systems, Inc. Implant having improved fixation to a body lumen and method for implanting the same
US6562069B2 (en) * 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
WO2003043676A2 (en) 2001-11-23 2003-05-30 Mindguard Ltd. Expandable delivery appliance particularly for delivering intravascular devices
US7182779B2 (en) 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US7090693B1 (en) 2001-12-20 2006-08-15 Boston Scientific Santa Rosa Corp. Endovascular graft joint and method for manufacture
CA2468951A1 (en) 2001-12-20 2003-07-03 Trivascular, Inc. Advanced endovascular graft
US7147661B2 (en) 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
US7201771B2 (en) * 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US20030130729A1 (en) 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
US20030199971A1 (en) 2002-04-23 2003-10-23 Numed, Inc. Biological replacement valve assembly
US6918926B2 (en) 2002-04-25 2005-07-19 Medtronic Vascular, Inc. System for transrenal/intraostial fixation of endovascular prosthesis
US7141064B2 (en) 2002-05-08 2006-11-28 Edwards Lifesciences Corporation Compressed tissue for heart valve leaflets
DE10221076A1 (de) 2002-05-11 2003-11-27 Ruesch Willy Gmbh Stent
US7044962B2 (en) 2002-06-25 2006-05-16 Scimed Life Systems, Inc. Implantable prosthesis with displaceable skirt
US20040024452A1 (en) * 2002-08-02 2004-02-05 Kruse Steven D. Valved prostheses with preformed tissue leaflets
AU2003272226A1 (en) 2002-08-20 2004-03-11 Cook Incorporated Stent graft with improved proximal end
US6878162B2 (en) 2002-08-30 2005-04-12 Edwards Lifesciences Ag Helical stent having improved flexibility and expandability
US7137184B2 (en) 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
US7316710B1 (en) * 2002-12-30 2008-01-08 Advanced Cardiovascular Systems, Inc. Flexible stent
US6918929B2 (en) * 2003-01-24 2005-07-19 Medtronic Vascular, Inc. Drug-polymer coated stent with pegylated styrenic block copolymers
US7399315B2 (en) * 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
US7220274B1 (en) 2003-03-21 2007-05-22 Quinn Stephen F Intravascular stent grafts and methods for deploying the same
US7096554B2 (en) 2003-04-04 2006-08-29 Boston Scientific Scimed, Inc. Protective loading of stents
EP1615595B1 (en) 2003-04-24 2009-10-21 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
US7041127B2 (en) 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
US20030216803A1 (en) 2003-05-28 2003-11-20 Ledergerber Walter J. Textured and drug eluting stent-grafts
JP2006526464A (ja) 2003-06-05 2006-11-24 フローメディカ，インコーポレイテッド 分枝した身体管腔において両側介入または診断を行うためのシステムおよび方法
US7201772B2 (en) * 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
US7959665B2 (en) * 2003-07-31 2011-06-14 Abbott Cardiovascular Systems Inc. Intravascular stent with inverted end rings
US8021421B2 (en) * 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
GB0321437D0 (en) * 2003-09-12 2003-10-15 Dystar Textilfarben Gmbh & Co High light fastness reactive red dyes
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
US20050075713A1 (en) * 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
WO2005034808A1 (en) 2003-10-10 2005-04-21 William A. Cook Australia Pty. Ltd. Fenestrated stent grafts
US7704740B2 (en) 2003-11-05 2010-04-27 Michigan State University Nanofibrillar structure and applications including cell and tissue culture
JP2007512919A (ja) 2003-12-04 2007-05-24 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 大動脈弁形成リング
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
CN100589779C (zh) 2003-12-23 2010-02-17 萨德拉医学公司 可再定位的心脏瓣膜
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US20110039690A1 (en) * 2004-02-02 2011-02-17 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US7470285B2 (en) 2004-02-05 2008-12-30 Children's Medical Center Corp. Transcatheter delivery of a replacement heart valve
US7225518B2 (en) 2004-02-23 2007-06-05 Boston Scientific Scimed, Inc. Apparatus for crimping a stent assembly
US7207204B2 (en) 2004-02-26 2007-04-24 Boston Scientific Scimed, Inc. Crimper
JP4975609B2 (ja) 2004-02-27 2012-07-11 エーオーテックス， インコーポレイテッド 補綴心臓弁送達システムおよびその方法
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
WO2005087140A1 (en) 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
CN101052359A (zh) * 2004-04-23 2007-10-10 3F医疗有限公司 可植入的人工瓣膜
NZ551646A (en) * 2004-06-09 2010-11-26 Pathogen Removal & Diagnostic Technologies Inc Particles embedded in a porous substrate for removing target analyte from a sample
EP1768630B1 (en) * 2004-06-16 2015-01-07 Machine Solutions, Inc. Stent crimping device
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
CN100352406C (zh) 2004-08-17 2007-12-05 微创医疗器械(上海)有限公司 组合式可任意方向弯曲的覆膜支架
US7919112B2 (en) 2004-08-26 2011-04-05 Pathak Holdings, Llc Implantable tissue compositions and method
US7704277B2 (en) 2004-09-14 2010-04-27 Edwards Lifesciences Ag Device and method for treatment of heart valve regurgitation
AU2004324043A1 (en) 2004-10-02 2006-04-20 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
PL2338440T3 (pl) 2004-11-02 2013-06-28 Machine Solutions Inc Technologia nakładania osłonki na stent
US7316148B2 (en) 2005-02-15 2008-01-08 Boston Scientific Scimed, Inc. Protective sheet loader
US8691543B2 (en) * 2009-11-25 2014-04-08 Worcester Polytechnic Institute Nanofibrous scaffold comprising immobilized cells
US8062359B2 (en) 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
EP1877012B1 (en) 2005-05-04 2017-04-26 Cook Medical Technologies LLC Expandable and retrievable stent
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
EP2901967B1 (en) * 2005-05-24 2019-10-02 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US7681430B2 (en) 2005-05-25 2010-03-23 Boston Scientific Scimed, Inc. Method and apparatus for reducing a stent
US7238200B2 (en) * 2005-06-03 2007-07-03 Arbor Surgical Technologies, Inc. Apparatus and methods for making leaflets and valve prostheses including such leaflets
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US20080058856A1 (en) 2005-06-28 2008-03-06 Venkatesh Ramaiah Non-occluding dilation device
US7670369B2 (en) 2005-10-13 2010-03-02 Cook Incorporated Endoluminal prosthesis
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US7563277B2 (en) 2005-10-24 2009-07-21 Cook Incorporated Removable covering for implantable frame projections
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
US8778017B2 (en) 2005-10-26 2014-07-15 Cardiosolutions, Inc. Safety for mitral valve implant
US7785366B2 (en) 2005-10-26 2010-08-31 Maurer Christopher W Mitral spacer
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
CA2631662C (en) * 2005-12-07 2014-08-05 Arbor Surgical Technologies, Inc. Connection systems for two piece prosthetic heart valve assemblies
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
EP1988851A2 (en) 2006-02-14 2008-11-12 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8219229B2 (en) * 2006-03-02 2012-07-10 Edwards Lifesciences Corporation Virtual heart valve
US8075615B2 (en) * 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
JP5016667B2 (ja) * 2006-04-29 2012-09-05 メドトロニック，インコーポレイテッド 複数部材の人工心臓弁アセンブリ並びにそれを用いた装置及びその使用方法
US20080021546A1 (en) 2006-07-18 2008-01-24 Tim Patz System for deploying balloon-expandable heart valves
WO2008015257A2 (en) 2006-08-02 2008-02-07 Syntach Ag Luminal implant with large expansion ratio
US8414643B2 (en) * 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
US20080220054A1 (en) * 2006-10-13 2008-09-11 Shastri V Prasad Modulation of drug release rate from electrospun fibers
US7655034B2 (en) 2006-11-14 2010-02-02 Medtronic Vascular, Inc. Stent-graft with anchoring pins
US7832251B2 (en) * 2006-11-15 2010-11-16 Abbott Laboratories Patterned mold for medical device
US9011754B2 (en) * 2006-12-05 2015-04-21 Nanyang Technological University Manufacturing three-dimensional scaffolds using electrospinning at low temperatures
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
EP2111190B1 (en) 2007-01-19 2013-10-09 Medtronic, Inc. Stented heart valve devices for atrioventricular valve replacement
CA2676588A1 (en) 2007-01-26 2008-07-31 3F Therapeutics, Inc. Methods and systems for reducing paravalvular leakage in heart valves
US20080183271A1 (en) 2007-01-31 2008-07-31 Abbott Laboratories Compliant crimping sheath
US20080208327A1 (en) 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US8002817B2 (en) * 2007-05-04 2011-08-23 Abbott Cardiovascular Systems Inc. Stents with high radial strength and methods of manufacturing same
US20080294248A1 (en) 2007-05-25 2008-11-27 Medical Entrepreneurs Ii, Inc. Prosthetic Heart Valve
BRPI0812372A2 (pt) 2007-06-04 2015-02-03 St Jude Medical Válvula cardíaca protética.
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US9814611B2 (en) 2007-07-31 2017-11-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US20090187197A1 (en) * 2007-08-03 2009-07-23 Roeber Peter J Knit PTFE Articles and Mesh
US8728154B2 (en) 2007-08-24 2014-05-20 St. Jude Medical, Inc. Prosthetic aortic heart valves
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
US20100249922A1 (en) 2007-09-19 2010-09-30 St Jude Medical Inc. Fiber-reinforced synthetic sheets for prosthetic heart valve leaflets
DE202008018589U1 (de) 2007-09-26 2016-03-14 St. Jude Medical, Inc. Zusammenfaltbare Herzklappenprothesen
US7803186B1 (en) * 2007-09-28 2010-09-28 St. Jude Medical, Inc. Prosthetic heart valves with flexible leaflets and leaflet edge clamping
US7981151B2 (en) * 2007-10-15 2011-07-19 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
EP3311779A1 (en) * 2007-10-25 2018-04-25 Symetis SA Stents, valved-stents and methods and systems for delivery thereof
US8597349B2 (en) 2007-11-05 2013-12-03 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with non-expanding stent posts and retrieval features
EP4079261A1 (en) * 2007-12-14 2022-10-26 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
JP5687070B2 (ja) 2008-01-24 2015-03-18 メドトロニック，インコーポレイテッド 人工心臓弁用のステント
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8034099B2 (en) * 2008-03-27 2011-10-11 Medtronic Vascular, Inc. Stent prosthesis having select flared crowns
EP2293745A1 (en) * 2008-04-18 2011-03-16 Cook Incorporated Branched vessel prosthesis
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US9061119B2 (en) * 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US9402724B2 (en) * 2008-05-12 2016-08-02 Mo-Sci Corporation Dynamic bioactive nanofiber scaffolding
EP2119417B2 (en) 2008-05-16 2020-04-29 Sorin Group Italia S.r.l. Atraumatic prosthetic heart valve prosthesis
US8291570B2 (en) * 2008-05-30 2012-10-23 Boston Scientific Scimed, Inc. Methods for abluminally coating medical devices
WO2009149462A2 (en) 2008-06-06 2009-12-10 Edwards Lifesciences Corporation Low profile transcatheter heart valve
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2010008548A2 (en) 2008-07-15 2010-01-21 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
CN102245129B (zh) 2008-07-21 2015-03-18 詹妮弗·K·怀特 可重新定位的腔内支撑结构及其应用
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
EP2367505B1 (en) 2008-09-29 2020-08-12 Edwards Lifesciences CardiAQ LLC Heart valve
NL1036038C (en) 2008-10-09 2010-04-14 Univ Eindhoven Tech Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof.
US20150265744A1 (en) * 2008-10-09 2015-09-24 Technische Universiteit Eindhoven Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof
CN102245256B (zh) 2008-10-10 2014-07-23 萨德拉医学公司 医疗装置以及用于输送医疗装置的输送系统
AU2009317876B2 (en) 2008-11-21 2014-01-16 Percutaneous Cardiovascular Solutions Pty Limited Heart valve prosthesis and method
US20160067374A1 (en) 2009-01-16 2016-03-10 Zeus Industrial Products, Inc. Composite prosthetic devices
JP5671004B2 (ja) 2009-04-13 2015-02-18 インテグリス・インコーポレーテッド 多孔性複合膜
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US8075611B2 (en) * 2009-06-02 2011-12-13 Medtronic, Inc. Stented prosthetic heart valves
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
US8475522B2 (en) 2009-07-14 2013-07-02 Edwards Lifesciences Corporation Transapical delivery system for heart valves
US10022222B2 (en) 2009-10-06 2018-07-17 Adam Groothuis Systems and methods for treating lumenal valves
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
WO2011109813A2 (en) 2010-03-05 2011-09-09 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
AU2011226695B2 (en) * 2010-03-11 2015-07-09 Board Of Regents Of The University Of Texas System Scaffold system to repair cardiovascular conditions
NZ602066A (en) * 2010-03-23 2013-09-27 Edwards Lifesciences Corp Methods of conditioning sheet bioprosthetic tissue
WO2011153340A2 (en) 2010-06-02 2011-12-08 The Regents Of The University Of Michigan Scaffolds and methods of forming the same
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
WO2012040655A2 (en) 2010-09-23 2012-03-29 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
CN105380730B (zh) * 2010-10-05 2018-08-17 爱德华兹生命科学公司 人工心脏瓣膜
DE202011111128U1 (de) 2010-10-05 2020-05-27 Edwards Lifesciences Corporation Prothetische Herzklappe
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US8945212B2 (en) 2011-04-01 2015-02-03 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
US9554900B2 (en) 2011-04-01 2017-01-31 W. L. Gore & Associates, Inc. Durable high strength polymer composites suitable for implant and articles produced therefrom
US8961599B2 (en) 2011-04-01 2015-02-24 W. L. Gore & Associates, Inc. Durable high strength polymer composite suitable for implant and articles produced therefrom
US9801712B2 (en) 2011-04-01 2017-10-31 W. L. Gore & Associates, Inc. Coherent single layer high strength synthetic polymer composites for prosthetic valves
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
EP2736456B1 (en) 2011-07-29 2018-06-13 Carnegie Mellon University Artificial valved conduits for cardiac reconstructive procedures and methods for their production
US20130331929A1 (en) 2011-09-09 2013-12-12 Endoluminal Sciences Pty Ltd. Means for Controlled Sealing of Endovascular Devices
US20130190857A1 (en) 2011-09-09 2013-07-25 Endoluminal Sciences Pty Ltd. Means for controlled sealing of endovascular devices
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
CA3201836A1 (en) 2011-12-09 2013-06-13 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
JP6250553B2 (ja) 2012-01-10 2017-12-20 エドワーズ ライフサイエンシーズ カーディアック エルエルシー 第２の支柱フィーチャを用いた連接型支持構造
US20130274873A1 (en) 2012-03-22 2013-10-17 Symetis Sa Transcatheter Stent-Valves and Methods, Systems and Devices for Addressing Para-Valve Leakage
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9132007B2 (en) 2013-01-10 2015-09-15 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage components for a transcatheter valve prosthesis
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
US8986375B2 (en) 2013-03-12 2015-03-24 Medtronic, Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
CN105517509B (zh) 2013-03-13 2017-08-08 爱德华兹生命科学卡迪尔克有限责任公司 铰接式连合瓣膜支架和方法
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
JP2016517748A (ja) 2013-05-03 2016-06-20 メドトロニック，インコーポレイテッド 弁に埋め込むための医療デバイス及び関連の方法
CA2908342C (en) 2013-05-20 2021-11-30 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
WO2015038458A1 (en) 2013-09-12 2015-03-19 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
CR20160240A (es) 2013-11-11 2016-08-04 Edwards Lifesciences Cardiaq Llc Sistemas y métodos para la manufactura del marco de una cánula
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
US9937037B2 (en) 2014-12-18 2018-04-10 W. L. Gore & Associates, Inc. Prosthetic valved conduits with mechanically coupled leaflets
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
US10603165B2 (en) 2016-12-06 2020-03-31 Edwards Lifesciences Corporation Mechanically expanding heart valve and delivery apparatus therefor
US11135056B2 (en) 2017-05-15 2021-10-05 Edwards Lifesciences Corporation Devices and methods of commissure formation for prosthetic heart valve
US10869759B2 (en) 2017-06-05 2020-12-22 Edwards Lifesciences Corporation Mechanically expandable heart valve

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104661618B (zh) * 2012-04-23 2016-10-26 奥泰克国际有限公司 瓣膜
CN104661618A (zh) * 2012-04-23 2015-05-27 奥泰克国际有限公司 瓣膜
CN111685915B (zh) * 2013-03-13 2024-01-09 爱德华兹生命科学卡迪尔克有限责任公司 铰接式连合瓣膜支架和方法
CN111685915A (zh) * 2013-03-13 2020-09-22 爱德华兹生命科学卡迪尔克有限责任公司 铰接式连合瓣膜支架和方法
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
CN105979911A (zh) * 2013-12-05 2016-09-28 爱德华兹生命科学公司 人工心脏瓣膜和递送装置
US10595993B2 (en) 2013-12-05 2020-03-24 Edwards Lifesciences Corporation Method of making an introducer sheath with an inner liner
US9901444B2 (en) 2013-12-17 2018-02-27 Edwards Lifesciences Corporation Inverted valve structure
CN105431109A (zh) * 2013-12-17 2016-03-23 爱德华兹生命科学公司 反向小叶人工瓣膜
CN106102658B (zh) * 2014-03-14 2018-06-15 杭州启明医疗器械有限公司 包括与瓣叶、顶部封套和底部封套互连的冠形件的心脏瓣膜；及医学植入物
CN106102658A (zh) * 2014-03-14 2016-11-09 杭州启明医疗器械有限公司 包括与瓣叶、顶部封套和底部封套互连的冠形件的心脏瓣膜；及医学植入物
CN106999282A (zh) * 2014-12-14 2017-08-01 特瑞森医疗有限公司 假体瓣膜和展开系统
US11045311B2 (en) 2014-12-14 2021-06-29 Trisol Medical Ltd. Prosthetic valve and deployment system
CN109952077A (zh) * 2016-12-06 2019-06-28 爱德华兹生命科学公司 可机械扩张的心脏瓣膜和其递送设备
CN109414322A (zh) * 2017-04-07 2019-03-01 上海甲悦医疗器械有限公司 一种人工瓣膜

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