DE03251884T1 - Zusammensetzungen gegen Krebs zur topischen Anwendung - Google Patents

Zusammensetzungen gegen Krebs zur topischen Anwendung Download PDF

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Publication number
DE03251884T1
DE03251884T1 DE03251884T DE03251884T DE03251884T1 DE 03251884 T1 DE03251884 T1 DE 03251884T1 DE 03251884 T DE03251884 T DE 03251884T DE 03251884 T DE03251884 T DE 03251884T DE 03251884 T1 DE03251884 T1 DE 03251884T1
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Prior art keywords
composition
composition according
approximately
soybean trypsin
undenatured
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Pending
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DE03251884T
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English (en)
Inventor
Stanley S. Shapiro
Miri Seiberg
Christine Paine
Allan H. Conney
Mou-Tuan Huang
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Rutgers State University of New Jersey
Johnson and Johnson Consumer Inc
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Rutgers State University of New Jersey
Johnson and Johnson Consumer Companies LLC
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Publication of DE03251884T1 publication Critical patent/DE03251884T1/de
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51Chelating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

Zusammensetzung zur Inhibierung des Fortschreitens eines kutanen Tumors oder zur Verhinderung oder Reduzierung des Hautkrebsrisikos, umfassend ein nicht-denaturiertes Sojaprodukt in einer Menge von ungefähr 0,01–99 Gewichtsprozent in einem topisch akzeptablen Träger.

Claims (19)

  1. Zusammensetzung zur Inhibierung des Fortschreitens eines kutanen Tumors oder zur Verhinderung oder Reduzierung des Hautkrebsrisikos, umfassend ein nicht-denaturiertes Sojaprodukt in einer Menge von ungefähr 0,01–99 Gewichtsprozent in einem topisch akzeptablen Träger.
  2. Zusammensetzung zur Inhibierung des Fortschreitens eines kutanen Tumors oder zur Verhinderung oder Reduzierung des Hautkrebsrisikos, umfassend einen nicht-denaturierten Sojabohnen-Trypsin-Inhibitor in einer Menge von ungefähr 0,01–99 Gewichtsprozent.
  3. Zusammensetzung gemäß Anspruch 1, umfassend von ungefähr 1 bis ungefähr 99% Sojabohnenmilch, von ungefähr 0,1 bis ungefähr 20% Emulgator und ein Konservierungsmittel in einer effektiven Menge.
  4. Zusammensetzung gemäß Anspruch 1, umfassend von ungefähr 0,1 bis ungefähr 20% Sojabohnenpulver oder Sojamilchpulver, von ungefähr 0,1 bis ungefähr 20% Emulgator und ein Konservierungsmittel in einer effektiven Menge.
  5. Zusammensetzung gemäß Anspruch 2, wobei besagte Zusammensetzung von ungefähr 0,01 bis ungefähr 99% Sojabohnen-Trypsin-Inhibitor, von ungefähr 0,1 bis ungefähr 20% Emulgator und ein Konservierungsmittel in einer effektiven Menge umfaßt.
  6. Zusammensetzung gemäß einem der vorangegangenen Ansprüche, umfassend ein kosmetisch akzeptables Vehikel.
  7. Zusammensetzung gemäß Anspruch 2, wobei besagter nicht-denaturierter Sojabohnen-Trypsin-Inhibitor in Liposomen, suspendiert in einem kosmetisch akzeptablen Träger, enthalten ist.
  8. Zusammensetzung gemäß einem der vorangegangenen Ansprüche, weiterhin umfassend mindestens ein Mittel ausgewählt aus der Gruppe bestehend aus Antioxidantien, Sonnenschutzmitteln, Feuchtigkeitscremes, Bleichmitteln, Depigmentierungsmitteln, Bräunigungsmitteln, oberflächenaktiven Stoffen, Schaumbildnern, Haarspülungen, Befeuchtungsmitteln, Duftstoffen, Anti-Alterungsmitteln, anti-inflammatorischen Mitteln und Anti-Krebsmitteln.
  9. Zusammensetzung gemäß einem der Ansprüche 1 bis 7, weiterhin mindestens ein anti-inflammatorisches Mittel umfassend.
  10. Zusammensetzung gemäß einem der Ansprüche 1 bis 7, weiterhin mindestens ein Anti-Krebsmittel umfassend.
  11. Zusammensetzung gemäß einem der Ansprüche 1 bis 7, weiterhin mindestens ein Antioxidans umfassend.
  12. Zusammensetzung gemäß einem der Ansprüche 1 bis 7, weiterhin mindestens ein Sonnenschutzmittel umfassend.
  13. Verwendung eines nicht-denaturierten Sojaproduktes zur Herstellung einer topischen pharmazeutischen Zusammensetzung zur Inhibierung des Fortschreitens eines kutanen Tumors oder zur Verhinderung oder Reduzierung des Hautkrebsrisikos.
  14. Verwendung eines nicht-denaturierten Sojabohnen-Trypsin-Inhibitors zur Herstellung einer topischen pharmazeutischen Zusammensetzung zur Inhibierung des Fortschreitens eines kutanen Tumors oder zur Verhinderung oder Reduzierung des Hautkrebsrisikos.
  15. Verwendung gemäß der Ansprüche 13 oder 14, wobei besagte Zusammensetzung für die Applikation mindestens einmal täglich auf einer dauerhaften Basis vorgesehen ist.
  16. Verwendung gemäß Anspruch 13 oder Anspruch 14, wobei besagte Zusammensetzung für die Applikation mindestens zweimal täglich für mindestens acht Wochen und danach mindestens einmal täglich auf einer dauerhaften Basis vorgesehen ist.
  17. Verwendung gemäß Anspruch 13, wobei besagte Zusammensetzung 0,05–80 Gewichtsprozent des besagten Sojaproduktes umfaßt und für mindestens ungefähr vier bis ungefähr zehn Wochen angewendet wird, gefolgt danach von topischer Applikation einer Zusammensetzung umfassend 0,01–20 Gewichtsprozent des besagten Sojaproduktes auf einer täglichen Basis.
  18. Verwendung gemäß Anspruch 14, wobei besagte Zusammensetzung 0,1–10 Gewichtsprozent des besagten nicht-denaturierten Sojabohnen-Trypsin-Inhibitors umfaßt und für mindestens ungefähr vier bis ungefähr zehn Wochen angewendet wird, gefolgt danach von topischer Applikation einer Zusammensetzung umfassend 0,01–10 Gewichtsprozent des besagten Sojabohnen-Trypsin-Inhibitors auf einer täglichen Basis.
  19. Verwendung gemäß der Ansprüche 13 bis 18, wobei besagte Zusammensetzung wie definiert in einem der Ansprüche 6 bis 12 vorliegt.
DE03251884T 2002-03-27 2003-03-26 Zusammensetzungen gegen Krebs zur topischen Anwendung Pending DE03251884T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US108248 1998-06-30
US10/108,248 US7309688B2 (en) 2000-10-27 2002-03-27 Topical anti-cancer compositions and methods of use thereof

Publications (1)

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DE03251884T1 true DE03251884T1 (de) 2004-09-30

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DE60306565T Expired - Lifetime DE60306565T2 (de) 2002-03-27 2003-03-26 Zusammensetzungen gegen Krebs zur topischen Anwendung
DE03251884T Pending DE03251884T1 (de) 2002-03-27 2003-03-26 Zusammensetzungen gegen Krebs zur topischen Anwendung

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US (3) US7309688B2 (de)
EP (1) EP1348441B1 (de)
BR (1) BR0300830A (de)
CA (1) CA2423524C (de)
DE (2) DE60306565T2 (de)

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US7309688B2 (en) 2007-12-18
CA2423524C (en) 2011-05-10
DE60306565T2 (de) 2007-07-05
US20030064049A1 (en) 2003-04-03
EP1348441A1 (de) 2003-10-01
DE60306565D1 (de) 2006-08-17
BR0300830A (pt) 2004-08-17
CA2423524A1 (en) 2003-09-27
EP1348441B1 (de) 2006-07-05
US20040247713A1 (en) 2004-12-09
US20050244523A1 (en) 2005-11-03

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