DE102007032664A1 - Cosmetic or dermatological preparations for skin care, protection and cleaning, containing apiogalacturonan compounds or extracts thereof from seaweed, together with molecular oxygen - Google Patents

Abstract

Preparations containing one or more apiogalacturonans (I) or extract(s) of (I) from Zostera marina and also containing molecular oxygen.

Description

The The present invention relates to a cosmetic or dermatological Preparations containing apiogalacturonans or a Apiogalacturonane extract from Zostera marina.

The The present invention relates in particular to cosmetic or dermatological Preparations containing active ingredients for care and protection the skin, especially the sensitive skin as well as very special in the foreground by intrinsic and / or extrinsic. Factors of aging or aging skin and the use of such Active substances and combinations of such active substances in the field of cosmetic and dermatological skin care.

Under Cosmetic skin care is to be understood in the first place that the natural function of the skin as a barrier against environmental influences (eg dirt, chemicals, microorganisms) and against the loss of endogenous substances (eg water, natural Fats, electrolytes) is strengthened or restored.

Becomes Disturbed by this feature, it can become overstressed Absorption of toxic or allergenic substances or infestation of Microorganisms and as a result to toxic or allergic skin reactions come.

at old skin, for example, the regenerative renewal slows down, in particular, the water-binding capacity of the horny layer subsides. It therefore becomes inflexible, dry and cracked ("physiologically" dry skin). A barrier damage is the consequence. The skin becomes susceptible to negative Environmental influences such as the invasion of microorganisms, Toxins and allergens. As a result, it can even become toxic or allergic skin reactions come.

at Pathologically dry and sensitive skin is a barrier damage a priori. Epidermal intercellular lipids become defective or formed in insufficient quantity or composition. The Consequence is an increased permeability of the Horny layer and inadequate protection of the skin from loss hygroscopic substances and water.

The Barrier action of the skin may be beyond the determination of transepidermal Water loss (TEWL - transepidermal water loss) become. This is the evaporation of water from the Interior of the body without the involvement of water loss Sweat. The determination of the TEWL value has proven to be extraordinary has proved informative and may be more chapped or crippled for diagnosis Skin, for the determination of compatibility chemically diverse built-up surfactants and the like can be used more.

For the beauty and care of the skin is the water content in the uppermost skin layer of paramount importance. It can be cheap to a limited extent by introducing moisture regulators influence.

anionic Surfactants, which are generally components of cleaning preparations are, the pH in the horny layer can be long lasting increase what regenerative processes that restore and renewal of the barrier function of the skin, severely hampered. In this case, in the horny layer arises between regeneration and the loss of essential substances through regular Extraction a new, often very unfavorable Equilibrium state, the external appearance the skin and the physiological functioning of the horny layer crucial impaired.

Nice in a simple water bath without the addition of surfactants it comes initially to a swelling of the horny layer of the skin, wherein the degree of this swelling, for example, on the duration of the bath and its temperature depends. At the same time become water-soluble Fabrics, e.g. B. water-soluble soil constituents, but also skin-own substances, which are responsible for the water-binding capacity the horny layer are responsible, or washed off. By skin's own surface-active substances also become skin fats to a certain extent solved and washed out. This conditionally after initial swelling a subsequent significant dehydration the skin, which is reinforced by detergent additives can be.

In healthy skin, these processes are generally irrelevant, as the protective mechanisms of the skin can readily compensate for such minor disorders of the upper layers of the skin. But even in the case of non-pathological deviations from the normal status, eg. B. by environmental wear damage or irritation, photodamage, aging skin, etc., the protective mechanism of the skin surface is disturbed. Under certain circumstances, he is then unable by his own power to fulfill his task and must by external measures are regenerated.

About that In addition, it is known that lipid composition and amount the horny layer of the pathologically altered, dry and the dry but not diseased skin younger and older people deviates from the normal state in healthy, normal-hydrated skin of the same age group is found. At the same time represent changes in a lipid pattern very dry, non-eczematous skin of patients with atopic eczema an extreme case for the deviations found in the dry skin of healthy people become.

These Deviations particularly concern the ceramides which in their amount greatly reduced and additionally composed differently are. A striking feature is the deficit of the Ceramides 1 and 3, wherein in particular for the ceramide 1 It is known that the order of the Lipids in the intercellular membrane systems increases.

Adverse Changes in the lipid membranes of the previously described Species may be due to aberrant lipid biosynthesis and also, in effect, increase transepidermal Water loss. A long-standing barrier barrier again makes the skin, which is healthy in itself, more sensitive and can in a single case to the emergence of eczematous processes in the sick Contribute to the skin.

The Effect of ointments and creams on barrier function and hydration The horny layer is usually not in a recovery or strengthening the physico-chemical properties of lamellae from intercellular lipids. An essential partial effect is based on the mere coverage of the treated skin areas and the resulting water retention in the underlying Stratum corneum. Co-applied hygroscopic substances bind this Water, causing a measurable increase in water content comes in the horny layer. This purely physical barrier can however, be relatively easily removed. After weaning of the product, the skin then returns very quickly to the condition back before treatment. In addition, can the skin care effect with regular treatment subside, so eventually even during the treatment of the status quo is achieved again. For certain Products, the condition of the skin worsens after weaning may be temporary. A sustainable one Product effect is usually not or only in a limited Dimensions achieved.

Around the deficient skin in its natural regeneration to support and strengthen their physiological function, In recent years, topical preparations are increasingly becoming intercellular lipid mixtures added by the skin to rebuild the natural Barrier should be used. However, it is these lipids, but especially the ceramides, very expensive raw materials. In addition, their effect is usually much less than hoped.

aim Thus, it has been the object of the present invention to find ways to overcome the disadvantages of the prior art. In particular, the effect should be the skin care products are physiological, fast and sustainable.

Under Skin care in the sense of the present invention is primarily to understand that the natural function of Skin as a barrier against environmental influences (eg dirt, Chemicals, microorganisms) and against the loss of the body's own Strengthened substances (eg water, lipids, electrolytes) or is restored.

Products for the care, treatment and cleaning of dry and stressed Skin is known. However, their contribution to regeneration a physiologically intact, hydrated and smooth horny layer extensive and limited in time.

The Effect of ointments and creams on barrier function and hydration the horny layer is based essentially on the cover (occlusion) of the treated dermal districts. The ointment or cream poses, so to speak a (second) artificial barrier that reduces water loss to prevent the skin. Accordingly, this physical Barrier - for example with cleaning agents - again be removed, causing the original, impaired State is reached again. In addition, the skin care effect relax with regular treatment. After this Discontinuing the product application, the skin returns very quickly back to the state before treatment. For certain Products may deteriorate the condition of the skin under certain circumstances even temporarily. A sustainable product effect becomes usually not or only in a limited Dimensions achieved.

The Effect of some pharmaceutical preparations on the barrier function the skin is even in a selective barrier damage, which should allow the active ingredients in or through the skin can invade the body. One Disturbed appearance of the skin is thereby as a side effect partially accepted.

The Effect of nourishing cleaning products consists essentially in an efficient refatting with sebum lipid-like Substances. By the simultaneous reduction of the surfactant content Such preparations can damage the horny layer barrier further limit.

the The prior art, however, lacks preparations which the barrier function and the hydration of the horny layer are positive affect and the physicochemical properties of the horny layer and in particular strengthen the lamellae from intercellular lipids or even restore.

gassy Cosmetic preparations are known per se and already in numerous Patents have been described. As gases, for example, oxygen, fluorinated gases, carbon dioxide, air, nitrogen and the like used.

One way to stabilize gases in cosmetic or dermatological preparations is z. Example, in making an O / W emulsion, which is then acted upon with gas. Such formulations are also known as mousses (for example WO 2002-074258-A1 ). A disadvantage of these preparations of the prior art is that the gas can be stabilized only by the use of emulsifiers. Another disadvantage is that the gas in the topical application or even when stored at 40 ° C or more (for example, in the car or on the beach) can escape into the atmosphere. Furthermore, the loading capacity of such preparations is usually rather low, so that physiological effects do not appear after the application.

Out the prior art are cosmetic preparations based on O / W emulsions containing oxygen are known.

The WO 02/05754 describes externally administrable preparations which contain an oxygen carrier which is molecularly incorporated into a lipid emulsion and their use for the external treatment / prevention of oxygen deficiency states of the skin.

The WO 02/05754 discloses O / W emulsions which are said to adequately provide oxygen transport through the lipid layer of the skin.

In the US 5851544 It is described that skin care formulations which increase the skin oxygen level are desirable because the oxygen content in the skin is lower than in other body regions and, in addition, decreases with increasing age. Task of US 5851544 It is, therefore, to increase the oxygen content of the skin in the long term or to remedy oxygen deficiency conditions in the skin.

In the DE 10333710 are cosmetic, dermatological or pharmaceutical preparations based on lipids and / or lipid / wax mixtures containing a gas or a gas mixture described.

The DE 10342449 . DE 10 2005 011 498 . DE 10 2005 011 457 and DE 10 2206 011 459 disclose cosmetic preparations containing molecular oxygen. Also herein preferred O / W emulsions are described. The oxygen-containing O / W emulsions are prepared by predispersing the inorganic gelling agent and swelling the hydrocolloid with stirring in the water phase. A combination of heated to 75 ° C fatty phase with the heated to 70 ° C water phase and adding the particulate hydrophobic, hydrophobized solid substances with stirring. It is then homogenized at 65 ° C and 45 min stirring under vacuum and cooling. The addition of the additives takes place at 30 ° C, the homogenization at 27 ° C. Subsequently, the gassing of the emulsion is carried out at 7-8 bar with oxygen.

The Production of oxygen-containing cosmetic preparations and in particular The step of oxygenation is listed in all Prior art documents under cooling, at room temperature or at a maximum of 30 ° C.

A disadvantage of the known preparations is that after incorporation of the molecular oxygen, the preparations are not stable storable, have a low oxygen loading capacity and have only low oxygen availability.

task It was therefore the object of the present invention to overcome the disadvantages of the prior art therefore, it is desirable to eliminate one's technique cosmetic preparation to provide the molecular oxygen contains and the one for cosmetics sufficient Shelf life. It is also desirable a process for the preparation of oxygen-containing emulsions To have available with a cosmetically applicable and storable preparation can be produced.

Especially should be skin care preparations and preparations for cleaning the skin are provided which the barrier properties maintain or restore the skin, especially if the natural Regeneration of the skin is not enough. They should also be used for treatment and prophylaxis of sequelae of skin dehydration, for example Fissures or inflammatory or allergic processes or also the eczema, be suitable. Task of the present It was also invention stable, skin-care cosmetic and / or to provide dermatological means which protect the skin from environmental influences such as sun and wind. In particular, the effect of the preparations should be physiological, be fast and sustainable.

The Plant genus Zostera belongs to the family of seagrass plants (Zosteraceae) and includes several submerged living species of the Sea grass in the seas. You can up to one Depth of 15m grow and include some of the few submerged ones Flowering plants.

Of the Name Zostera is the Greek "zoster" (Zωστἡρ) ajar, which means "belt" and to the should remember flat ribbon-shaped leaves. Worldwide There are twelve recognized species, all of them only in the Oceans occur and grow mostly in seagrass meadows.

The Common seagrass (Zostera marina) grows submerged (submers) on the sea shores and form there together with other marine angiosperms flowering plants undersea Seagrass beds.

From Zostera marina, the polysaccharide zosteran extractable, a apio-rich polysaccharide consisting of an α-1,4-D-galactopyranosyluronan backbone substituted with 1,2-linked apiofuranose oligosaccharides and single apioseric residues, is extractable using standard extraction techniques.

According to the invention Preparations containing apiogalacturonans or a Apiogalacturonane extract containing Zostera marina as well proposed a content of molecular oxygen. They are in in every respect extremely satisfactory preparations.

• – besser die Barriereeigenschaften der Haut erhalten oder wiederherstellen,
• – besser der Hautaustrocknung entgegenwirken,
• – besser gegen Pigmentstörungen wirken,
• – besser gegen entzündliche Hautzustände wirken
• – besser gegen die Hautalterung wirken und
• – die Haut besser vor Umwelteinflüssen schützen

als die Zubereitungen des Standes der Technik.It was not foreseeable for the skilled person that such preparations

• - better maintain or restore the barrier properties of the skin,
• - better counteract skin dehydration,
• - better against pigment disorders,
• - work better against inflammatory skin conditions
• - Act better against aging skin and
• - Protect the skin better from environmental influences

as the preparations of the prior art.

• – von defizitären, sensitiven oder hypoaktiven Hautzuständen oder defizitären, sensitiven oder hypoaktiven Zustände von Hautanhangsgebilden
• – von Erscheinungen vorzeitiger Alterung der Haut (z. B. Falten, Altersflecken, Teleangiektasien) und/oder der Hautanhangsgebilde,
• – von umweltbedingten (Rauchen, Smog, reaktive Sauerstoffspecies, freie Radikale) und insbesondere lichtbedingten negativen Veränderungen der Haut und der Hautanhangsgebilde.
• – von lichtbedingten Hautschäden
• – von Pigmentierungsstörungen,
• – von empfindlicher, gereizter und juckender Haut,
• – von trockenen Hautzuständen und Hornschichtbarrierestörungen,
• – von Haarausfall und für verbessertes Haarwachstum
• – von entzündlichen Hautzuständen sowie atopischem Ekzem, seborrhoischem Ekzem, polymorpher Lichtdermatose, Psoriasis, Vitiligo

möglich. Der erfindungsgemäße Wirkstoffes bzw. kosmetischer oder topischer dermatologischer Zubereitungen mit einem wirksamen Gehalt an erfindungsgemäßem Wirkstoff dient aber auch in überraschender Weise

• – zur Beruhigung von empfindlicher oder gereizter Haut
• – zur Stimulation der Kollagen-, Hyaluronsäure-, Elastinsynthese
• – zur Stimulation der Ceramidsynthese der Haut
• – zur Stimulation der intrazellulären DNA-Synthese, insbesondere bei defizitären oder hypoaktiven Hautzuständen.
• – zur Steigerung der Zellerneuerung und Regeneration der Haut
• – zur Steigerung der hauteigenen Schutz- und Reparaturmechanismen (beispielsweise für dysfunktionelle Enzyme, DNA, Lipide, Proteine)
• – zur Vor- und Nachbehandlung bei topischer Anwendung von Laser- und Abschleifbehandlungen, die z. B. der Reduzierung von Hautfalten und Narben dienen, um den resultierenden Hautreizungen entgegenzuwirken und die Regenerationsprozesse in der verletzten Haut zu fördern.

The use of cosmetic od containing apiogalacturonans or Apiogalactu ronane-containing extract of zostera marina surprisingly provides an effective treatment, but also prophylaxis

• - of deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive states of skin appendages
• - signs of premature aging of the skin (eg wrinkles, age spots, telangiectasias) and / or the appendages of the skin,
• - of environmental factors (smoking, smog, reactive oxygen species, free radicals) and in particular light-induced negative changes in the skin and the appendages.
• - of light-induced skin damage
• - pigmentation disorders,
• - of sensitive, irritated and itchy skin,
• Dry skin conditions and corneal barrier disorders,
• - from hair loss and for improved hair growth
• - of inflammatory skin conditions as well as atopic eczema, seborrheic eczema, polymorphic photodermatosis, psoriasis, vitiligo

possible. The active ingredient according to the invention or cosmetic or topical dermatological preparations with an effective content of the active ingredient according to the invention, however, also serves in a surprising manner

• - to soothe sensitive or irritated skin
• - To stimulate collagen, hyaluronic acid, elastin synthesis
• - to stimulate the ceramide synthesis of the skin
• - To stimulate intracellular DNA synthesis, especially in deficient or hypoactive skin conditions.
• - to increase the cell renewal and regeneration of the skin
• - to increase the skin's own protective and repair mechanisms (eg for dysfunctional enzymes, DNA, lipids, proteins)
• - For pre- and post-treatment in topical application of laser and Abschleifbehandlungen z. As the reduction of skin wrinkles and scars serve to counteract the resulting skin irritation and promote the regeneration processes in the injured skin.

Advantageous is in particular a use according to the invention, characterized in that the preparations are 0.0001 to 10% by weight, in particular 0.001 to 5% by weight, very particularly 0.01 to 4% by weight of apiogalacturonans or an apiogalacturonane contained extract of Zostera marina, based on the Total weight of the preparation.

Advantageous contain the preparations according to the invention 5-50% by volume of oxygen, preferably 10-20 % By volume, more preferably 12-17% by volume.

The cosmetic or dermatological according to the invention Preparation, advantageously based on an emulsion, in particular an O / W emulsion comprising molecular oxygen and an or several apiogalacturonans or an apiogalacturonan or apiogalacturonans containing Zostera marina extract is characterized by that it is obtainable by usual mixing and preparing an emulsion and then gassing the preparation with gaseous oxygen and / or oxygen-containing Gases. The preparation is at room temperature (about 20 to 25 ° C) fed into the mixer and then fumigated.

invention Cosmetic and dermatological preparations can be used in different forms exist. So they can z. Legs Solution, an anhydrous preparation, an emulsion or Micro-emulsion of the water-in-oil (W / O) or oil-in-water type (O / W), a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W), a gel, a solid stick, an ointment or even an aerosol represent. It is also advantageous in accordance with the invention To present folic acid and / or its derivatives in encapsulated form, z. In collagen matrices and other common encapsulation materials, z. As cellulose encapsulates, in gelatin, wax matrices or encapsulated liposomally.

In particular wax matrices like those in the DE-OS 43 08 282 have been described, have turned out to be favorable.

The cosmetic and dermatological preparations according to the invention may contain cosmetic adjuvants such as are conventionally used in such preparations, eg. As preservatives, bactericides, perfumes, substances for preventing foaming, dyes, pigments, a fär have thickening agents, surface-active substances, emulsifiers, softening, moistening and / or moisturizing substances, fats, oils, waxes or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

• – Mineralöle, Mineralwachse
• – Öle, wie Triglyceride der Caprin- oder der Caprylsäure, ferner natürliche Öle wie z. B. Rizinusöl;
• – Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z. B. mit Isopropanol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C-Zahl oder mit Fettsäuren;
• – Alkylbenzoate;
• – Siliconöle wie Dimethylpolysiloxane, Diethylpolysiloxane, Diphenylpolysiloxane sowie Mischformen daraus.

The lipid phase can advantageously be selected from the following substance group:

• - mineral oils, mineral waxes
• - Oils such as triglycerides of capric or caprylic, further natural oils such. Castor oil;
• Fats, waxes and other natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, e.g. With isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
• - alkyl benzoates;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously chosen from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a Chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched Alcohols of a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then are advantageously selected from the group isopropyl myristate, Isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, Oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, z. B. jojoba oil.

The aqueous phase of the invention Preparations optionally contains advantageous alcohols, Diols or polyols of low C number, and their ethers, preferably Ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or -monobutyl ether, propylene glycol monomethyl, -monoethyl- or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore lower C number alcohols, e.g. Ethanol, Isopropanol, 1,2-propanediol, glycerol and in particular one or more Thickener, which or which are chosen advantageous can be selected from the group silicon dioxide, aluminum silicates, Polysaccharides or their derivatives, for. Hyaluronic acid, Xanthan gum, hydroxypropyl methylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the Group of so-called carbopols, for example carbopols of the types 980, 981, 1382, 2984, 5984, each alone or in combination.

Especially Mixtures of the abovementioned solvents are used. For alcoholic solvents, water can be another Be part of it.

invention Emulsions are advantageous and contain z. As mentioned fats, oils, Waxes and other fatty substances, as well as water and an emulsifier, as he usually does for such a type of formulation is used.

gels according to the invention usually contain Low C-number alcohols, e.g. Ethanol, isopropanol, 1,2-propanediol, Glycerol and water or an aforementioned. Oil in Presence of a thickening agent that is oily-alcoholic Preferably, silica or an aluminosilicate is included aqueous-alcoholic or alcoholic gels preferably a polyacrylate.

When Blowing agent for the invention, from Aerosol containers are sprayable preparations the usual known volatile, liquefied Propellants, for example hydrocarbons (propane, butane, isobutane) suitable, which are used alone or in mixture with each other can. Also, compressed air is advantageous to use.

Advantageously, preparations according to the invention may also contain substances that absorb UV radiation in the UVB range, wherein the total amount of the filter substances z. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 10 wt .-%, in particular 1.0 to 6.0 wt .-%, based on the total weight of the preparations to cosmetic To provide preparations that protect the hair or the skin from the entire range of ultraviolet radiation. You can also use it as a sunscreen tel for hair or skin.

The following examples are intended to illustrate the present invention without limiting it. All amounts, proportions and percentages are, unless otherwise stated, percentages by weight, based on the weight and the total amount or on the total weight of the preparations. Mousse Foundation 1: Product name Amount [%] Aqua Ad 100.00 glycerin 5.00 Polyglyceryl-3 Methylglucose Distearate 4.00 Ethylhexyl methoxycinnamate + BHT 1.50 Cyclomethicone 4.00 Cetyl Alcohol 2.00 Myristyl myristate 2.00 oxygen 15.00 Tocopheryl acetate 1.50 Trisodium EDTA 1.00 Dimethicone 1.00 C12-15 alkyl benzoates 1.00 Dicaprylyl carbonates 1.00 Butyl methoxydibenzoylmethane 0.70 Zostera marina extract 3.00 phenoxyethanol 0.35 Xanthan gum 0.40 Perfume 0.20 Caprylyl glycol 0.25 methylparaben 0.10 Ethylparaben 0.10 Propylparaben 0.10 Citric Acid 0.06 BHT 0.05 Mousse Foundation 2: Product name Amount [%] Aqua Ad 100.00 Cyclomethicone 4.00 glycerin 6.00 Dicaprylyl ether 3.00 Cetyl Dimethicone 3.00 Caprylic / Capric Triglycerides 2.00 Hydrogenated Coco-Glycerides 2.00 Nylon-12 1.50 Glyceryl Stearate Citrate 2.00 Cetyl Alcohol 1.50 oxygen 20.00 Stearyl Alcohol 1.50 panthenol 1.50 Trisodium EDTA 1.00 Carbomer 0.7 Zostera marina extract 1.50 Tocopheryl acetate 1.50 phenoxyethanol 0.30 Perfume 0.30 Caprylyl glycol 0.20 methylparaben 0.20 Ethylparaben 0.20 Propylparaben 0.30 Aqua + Sodium Hydroxide 0.10 BHT 0.05

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - WO 2002-074258 A1 [0025]
• WO 02/05754 [0027, 0028]
• US 5851544 [0029, 0029]
• - DE 10333710 [0030]
• - DE 10342449 [0031]
• - DE 102005011498 [0031]
• - DE 102005011457 [0031]
• - DE 102206011459 [0031]
• - DE 4308282 A [0047]

Claims (3)

Preparations containing apiogalacturonanes or an extract of Zostera marina containing apiogalacturonan and a molecular oxygen content. Preparations according to claim 1, by a content from 0.0001 to 10% by weight of apiogalacturonans or an apiogalacturonane containing extract of Zostera marina, in particular 0.001 to 5 wt .-%, very particularly 0.01 to 4 wt .-%, based on the total weight of the preparation. Preparations according to claim 1, containing 5-50 % By volume of oxygen, preferably 10-20% by volume, in particular preferably 12-17 volumes -.%