DE141967C - - Google Patents
Info
- Publication number
- DE141967C DE141967C DENDAT141967D DE141967DA DE141967C DE 141967 C DE141967 C DE 141967C DE NDAT141967 D DENDAT141967 D DE NDAT141967D DE 141967D A DE141967D A DE 141967DA DE 141967 C DE141967 C DE 141967C
- Authority
- DE
- Germany
- Prior art keywords
- silver
- compounds
- water
- gelatoses
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- SQGYOTSLMSWVJD-UHFFFAOYSA-N Silver nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 10
- 229940027985 antiseptics and disinfectants Silver compounds Drugs 0.000 claims description 8
- 150000003379 silver compounds Chemical class 0.000 claims description 8
- 229940100890 silver compounds Drugs 0.000 claims description 8
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000003472 neutralizing Effects 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 21
- 229910052709 silver Inorganic materials 0.000 description 21
- 239000004332 silver Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 230000001264 neutralization Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 238000009835 boiling Methods 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 230000002378 acidificating Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000010956 nickel silver Substances 0.000 description 2
- 150000003378 silver Chemical class 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 108010021588 strong silver protein Proteins 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- FYEHYMARPSSOBO-UHFFFAOYSA-N Aurin Chemical compound C1=CC(O)=CC=C1C(C=1C=CC(O)=CC=1)=C1C=CC(=O)C=C1 FYEHYMARPSSOBO-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 229940084947 Glutose Drugs 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- KJFMBFZCATUALV-UHFFFAOYSA-N Phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 1
- -1 Protargol Chemical compound 0.000 description 1
- 108010082714 Silver Proteins Proteins 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-M Sodium 2-anthraquinonesulfonate Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)[O-])=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000005591 charge neutralization Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229910000464 lead oxide Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- YEXPOXQUZXUXJW-UHFFFAOYSA-N oxolead Chemical compound [Pb]=O YEXPOXQUZXUXJW-UHFFFAOYSA-N 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
Es wurde die Beobachtung gemacht, daß man aus Gelatosen neutrale wasserlösliche hochprozentige Silberverbindungen gewinnen kann, in welchen das Silber maskiert fest gebunden ist und die vermöge dieser Eigenschaft therapeutisch wertvoll sind ; sie enthalten bis 20 Prozent und mehr Silber.The observation was made that neutral, water-soluble high-proofs can be obtained from gelatoses Silver compounds can win, in which the silver is masked and firmly bound and which because of this property are therapeutically valuable; they contain up to 20 percent and more silver.
Unter Gelatosen sind zu verstehen: Spaltungsprodukte des Glutins und Aldehydglutins, die daraus durch Säuren oder Alkalien, durch Kochen mit Wasser bei gewöhnlichem oder erhöhtem Druck, in saurer, alkalischer oder Salzlösung, durch Fäulnis oder auch durch Verdauung entstehen und die in der Literatur unter den Namen Glutosen (Proto-, Deuterousw. Glutose), Leimpepton, Leimalbumose, Semiglutin usw. bekannt sind.Gelatoses are understood to mean: cleavage products of glutin and aldehyde glutin, obtained therefrom by acids or alkalis, by boiling with water at ordinary or increased pressure, in acidic, alkaline or saline solution, through rotting or even through Digestion and which in the literature under the name glutoses (Proto-, Deuterousw. Glutose), glue pepton, glue albumose, semiglutin etc. are known.
Zur Gewinnung der neuen Silberverbindungen wird in der Weise verfahren, daß man die wässerige Lösung der Gelatosen neutralisiert, mit Silbernitratlösung versetzt und sodann eindampft oder die Silberverbindungen durch Alkohol oder Aceton fällt.To obtain the new silver compounds, the procedure is that the aqueous solution of the gelatoses neutralized, mixed with silver nitrate solution and then evaporated or the silver compounds are precipitated by alcohol or acetone.
Beim Verarbeiten größerer Mengen ist es nötig, in sehr schwach alkalischer Lösung einzudampfen, um zu einem völlig neutralen Endprodukt zu gelangen.When processing larger quantities, it is necessary to evaporate in a very weakly alkaline solution, in order to arrive at a completely neutral end product.
Die Gelatosen, wie sie z. B. Hofmeister beschreibt, sind mehr oder weniger sauer reagierende Verbindungen. Für die Gewinnung der Silberverbindungen der Gelatose ist es notwendig, dieselben unter Zugabe eines Neutralisationsmittels zu verwenden. Als solche kommen z. B. in Betracht: Alkalien, alkalisch reagierende Salze, organische Basen usw. Dieselben werden, um Neutralisation zu erreichen, unter Zuhülfenahme eines Indikators, z. B. Lakmus, Phenolphtalein, Rosolsäure, der GeIatoselösung zugesetzt.The gelatoses, as they are z. B. Hofmeister describes are more or less acidic reacting compounds. For the extraction of the silver compounds of gelatose it is necessary to add a neutralizing agent to the same to use. As such come z. B. into consideration: alkalis, alkaline reacting salts, organic bases, etc. The same in order to achieve neutralization, with the aid of an indicator, e.g. B. Lakmus, phenolphthalein, rosolic acid, the gelatose solution added.
4040
I. 100 g Gelatose, aus gereinigtem Leim durch Erhitzen mit gespanntem Wasserdampf von ι 500 erhalten, werden in 40 g Wasser auf dem Wasserbad gelöst und durch 1,1 g Natronhydrat in 3 ecm Wasser schwach alkalisch gemacht, so daß Lakmuspapier schwach, aber deutlich blau gefärbt wird. Dann vermischt man mit 45 g Silbernitrat in 25 ecm Wasser. Die Mischung wird im Vakuum zur Trockne gebracht und enthalt 19,5 Prozent Silber.I. 100 g of gelatose, obtained from purified glue by heating with pressurized steam of ι 50 0 , are dissolved in 40 g of water on a water bath and made weakly alkaline by 1.1 g of sodium hydrate in 3 ecm of water, so that liquor paper weak, but becomes distinctly blue in color. Then mix with 45 g of silver nitrate in 25 ecm of water. The mixture is brought to dryness in vacuo and contains 19.5 percent silver.
II. 100 g Semiglutin werden in 50 g Wasser auf dem Wasserbad gelöst und nach dem Neutralisieren durch 0,75 g Natronhydrat in Wasser mit 15 g Silbernitrat in ι ο ecm Wasser vermischt. Die im Vakuum zur Trockne gebrachte Mischung stellt ein Pulver dar mit einem Silbergehalt von 8,5 Prozent.II. 100 g of semiglutin are in 50 g of water dissolved on the water bath and after neutralizing with 0.75 g of sodium hydrate in water mixed with 15 g of silver nitrate in ι ο ecm water. The mixture, brought to dryness in a vacuum, is a powder with a silver content of 8.5 percent.
III. Gelatine wird in der üblichen Weise mit Pepsin-Salzsäure verdaut, dann wird das Produkt mit frisch gefälltem Bleioxyd gekocht, entbleit und nach dem Dialysieren eingedampft. 100 g dieses Produkts, nach Beispiel III weiter verarbeitet, geben ein Silbersalz mit 8,5 Prozent Silber.III. Gelatin is digested in the usual way with pepsin hydrochloric acid, then that becomes Product boiled with freshly precipitated lead oxide, unleaded and evaporated after dialysis. 100 g of this product, further processed according to Example III, give a silver salt with 8.5 percent Silver.
IV. Formaldehydgelatine wird durch Kochen mit Sodalösung (1 : 10000) in Gelatose übergeführt. 100 g dieses Produkts werden in 40 ecm Wasser gelöst, durch 0,12 g Natronhydrat neutralisiert und mit einer konzentriertenIV. Formaldehyde gelatine is converted into gelatose by boiling with soda solution (1: 10000). 100 g of this product are dissolved in 40 ecm of water with 0.12 g of sodium hydroxide neutralized and with a concentrated
Lösung von 25 g Silbernitrat vermischt. Das zur Trockne gebrachte Gemisch enthält 12 Prozent Silber.Mixed solution of 25 g of silver nitrate. The mixture brought to dryness contains 12 percent Silver.
Die nach diesem Verfahren hergestellten Silbersalze bilden gelbweiße Pulver, die sich in Wasser mit neutraler Reaktion lösen. 50 prozentige wässerige Lösungen sind noch leicht herstellbar. Spezifische Silberreagentien, wie verdünnte Salzsäure, Kochsalzlösung, Schwefel-Wasserstoff, geben mit den Lösungen der neuen Silbersalze keine Niederschläge. Hexamethylentetrarninlösung gibt einen Niederschlag, der sich im Überschuß des Fällungsmittels leicht löst. Die Lösung läßt sich zu einem leicht löslichen Pulver eindampfen. Auch mit Harnstoff, Piperazin und dergl. lassen sich durch Eindampfen der Lösungen der beiden Bestandteile leicht lösliche Doppelverbindungen herstellen.The silver salts produced by this process form yellow-white powders, which are dissolve in water with a neutral reaction. 50 percent aqueous solutions are still easy manufacturable. Specific silver reagents, such as dilute hydrochloric acid, saline solution, sulfur-hydrogen, do not give any precipitates with the solutions of the new silver salts. Hexamethylenetetrarnine solution gives a precipitate which dissolves easily in excess of the precipitant. The solution can be easily soluble Evaporate the powder. Urea, piperazine and the like can also be used by evaporation the solutions of the two components produce easily soluble double compounds.
Silberverbindungen, in denen das Silber ähnlieh gebunden ist, wie im Glutinsilber, sind bereits bekannt und finden therapeutische Verwendung. Die bisher bekannten Produkte dieser Art sind entweder Verbindungen von nativem Eiweiß und Silber wie das lösliche Cascinsilber (Argonin) oder Verbindungen von Albumosen mit Silber, wie Protargol, und haben einen Silbergehalt von 4,2 bezw. 7,8 Prozent. Gibt man zu Lösungen von Argonin oder Protargol Silberlösung, so entstehen unlösliche Verbindüngen. Es lassen sich deshalb aus den betreffenden Eiweißstoffen lösliche Silberverbindungen, die den angegebenen Silbergehalt wesentlich überschreiten, nicht herstellen. Ähnlich verhalten sich die neutralen Lösungen sämtlicher Proteinkörper.Silver compounds in which the silver is bound in a similar way as in glutinic silver already known and used therapeutically. The previously known products of this Art are either compounds of native protein and silver such as the soluble cascine silver (Argonin) or compounds of albumoses with silver, such as Protargol, and have one Silver content of 4.2 and 7.8 percent. Are added to solutions of argonin or protargol Silver solution, this creates insoluble compounds. It can therefore be derived from the relevant Do not produce silver compounds soluble in protein substances that significantly exceed the specified silver content. Similar the neutral solutions of all protein bodies behave.
Im Gegensatz hierzu geben neutrale Lösungen der Gelatosen mit Silberlösungen keine Niederschläge, so daß sich mit großer Leichtigkeit und nach weit einfacherem Verfahren als bei den Proteinen aus den Gelatosen sehr hochprozentige Silberverbindungen herstellen lassen. Da bei der Herstellung von Albumosesilber der höhere Silbergehalt dieses Produkts gegenüber dem Caseinsilber als ein großer Fortschritt erkannt worden ist, so wird die Überlegenheit des weit höherprozentigen Gelatosesilbers über die bisherigen Silbereiweißverbindungen ohne weiteres einleuchten.In contrast to this, neutral solutions of the gelatoses with silver solutions do not give any precipitates, so that very high percentage can be obtained with great ease and by a much simpler process than with the proteins from the gelatoses Have silver connections made. As in the production of albumose silver the higher silver content of this product compared to the casein silver as a big step forward has been recognized, the superiority of the much higher percentage gelatin silver over the previous silver-protein compounds.
Claims (1)
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DE141967C true DE141967C (en) |
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Family Applications (1)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5285845A (en) * | 1991-01-15 | 1994-02-15 | Nordinvent S.A. | Heat exchanger element |
US5438477A (en) * | 1993-08-12 | 1995-08-01 | Lsi Logic Corporation | Die-attach technique for flip-chip style mounting of semiconductor dies |
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0
- DE DENDAT141967D patent/DE141967C/de active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5285845A (en) * | 1991-01-15 | 1994-02-15 | Nordinvent S.A. | Heat exchanger element |
US5438477A (en) * | 1993-08-12 | 1995-08-01 | Lsi Logic Corporation | Die-attach technique for flip-chip style mounting of semiconductor dies |
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