DE19775085I2 - N-Phosphonylmethoxyalkyl-Derivate von Pyrimidin- und Purinbasen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antiviraler Wirkung, die sie enthalten. - Google Patents
N-Phosphonylmethoxyalkyl-Derivate von Pyrimidin- und Purinbasen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antiviraler Wirkung, die sie enthalten.Info
- Publication number
- DE19775085I2 DE19775085I2 DE1997175085 DE19775085C DE19775085I2 DE 19775085 I2 DE19775085 I2 DE 19775085I2 DE 1997175085 DE1997175085 DE 1997175085 DE 19775085 C DE19775085 C DE 19775085C DE 19775085 I2 DE19775085 I2 DE 19775085I2
- Authority
- DE
- Germany
- Prior art keywords
- antiviral activity
- pyrimidine
- preparation
- pharmaceutical compositions
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS865469A CS264222B1 (en) | 1986-07-18 | 1986-07-18 | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19775085I2 true DE19775085I2 (de) | 2004-01-15 |
Family
ID=5399635
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787110399T Expired - Lifetime DE3765864D1 (de) | 1986-07-18 | 1987-07-17 | N-phosphonylmethoxyalkyl-derivate von pyrimidin- und purinbasen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen mit antiviraler wirkung, die sie enthalten. |
DE1997175085 Active DE19775085I2 (de) | 1986-07-18 | 1987-07-17 | N-Phosphonylmethoxyalkyl-Derivate von Pyrimidin- und Purinbasen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antiviraler Wirkung, die sie enthalten. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787110399T Expired - Lifetime DE3765864D1 (de) | 1986-07-18 | 1987-07-17 | N-phosphonylmethoxyalkyl-derivate von pyrimidin- und purinbasen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen mit antiviraler wirkung, die sie enthalten. |
Country Status (21)
Country | Link |
---|---|
US (3) | US5142051A (de) |
EP (1) | EP0253412B1 (de) |
JP (1) | JPH0822866B2 (de) |
KR (1) | KR950004179B1 (de) |
AT (1) | ATE57932T1 (de) |
AU (1) | AU600002B2 (de) |
CA (1) | CA1340856C (de) |
CS (1) | CS264222B1 (de) |
DE (2) | DE3765864D1 (de) |
DK (1) | DK170646B1 (de) |
EG (1) | EG18273A (de) |
ES (1) | ES2036194T3 (de) |
FI (1) | FI86856C (de) |
GR (1) | GR3002534T3 (de) |
IE (1) | IE60117B1 (de) |
IL (1) | IL83235A (de) |
LU (1) | LU90155I2 (de) |
NL (1) | NL970036I2 (de) |
NZ (1) | NZ221100A (de) |
PT (1) | PT85354B (de) |
ZA (1) | ZA875283B (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
NZ222553A (en) * | 1986-11-18 | 1991-07-26 | Bristol Myers Co | Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions |
US5650510A (en) * | 1986-11-18 | 1997-07-22 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives |
JPH0217199A (ja) * | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | 2’−デオキシ−β−アデノシンの製造方法 |
US5688778A (en) * | 1989-05-15 | 1997-11-18 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Nucleoside analogs |
EP0452935B1 (de) * | 1990-04-20 | 1995-06-21 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Chirale 2-(Phosphonomethoxy)propyl-Guanine als antivirale Agentien |
US5302585A (en) * | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
SK280313B6 (sk) * | 1990-04-24 | 1999-11-08 | �Stav Organick� Chemie A Biochemie Av �R | N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov |
CS276072B6 (en) * | 1990-08-06 | 1992-03-18 | Ustav Organicke Chemie A Bioch | (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF |
AU653552B2 (en) * | 1990-08-10 | 1994-10-06 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Novel process for the preparation of nucleotides |
EP0481214B1 (de) * | 1990-09-14 | 1998-06-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Wirkstoffvorläufer von Phosphonaten |
US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
KR0184530B1 (ko) * | 1991-10-11 | 1999-05-15 | 카렐 마르티넥 | 항비루스 비고리 포스포노메톡시알킬치환, 알켄일 및 알킨일 퓨린 및 피리미딘 유도체 |
US6057305A (en) * | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
US5817647A (en) * | 1993-04-01 | 1998-10-06 | Merrell Pharmaceuticals Inc. | Unsaturated acetylene phosphonate derivatives of purines |
US5514798A (en) * | 1993-06-02 | 1996-05-07 | Gilead Sciences, Inc. | Method and cyclic carbonates for nucleotide analogues |
US5656745A (en) * | 1993-09-17 | 1997-08-12 | Gilead Sciences, Inc. | Nucleotide analogs |
JPH09506333A (ja) * | 1993-09-17 | 1997-06-24 | ギリアード サイエンシーズ,インコーポレイテッド | 治療化合物の投薬方法 |
US5502177A (en) * | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US5468752A (en) * | 1994-04-04 | 1995-11-21 | Freeman; William R. | Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines |
JPH09511507A (ja) * | 1994-04-04 | 1997-11-18 | フリーマン,ウイリアム・アール | 上昇した眼圧を治療するためのホスホニルメトキシアルキルヌクレオシドの使用 |
US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
US5717095A (en) * | 1995-12-29 | 1998-02-10 | Gilead Sciences, Inc. | Nucleotide analogs |
US6093816A (en) | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
CN1763056B (zh) * | 1997-07-25 | 2013-01-16 | 吉尔利德科学股份有限公司 | 核苷酸类似物组合物 |
DK1382343T3 (da) * | 1998-11-02 | 2010-04-26 | Gilead Sciences Inc | Kombinationsterapi til behandling af hepatitis B-virus |
US6407077B1 (en) | 1998-11-05 | 2002-06-18 | Emory University | β-L nucleosides for the treatment of HIV infection |
US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
AU3540101A (en) * | 2000-01-07 | 2001-07-16 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
AUPQ806700A0 (en) * | 2000-06-08 | 2000-07-06 | Commonwealth Scientific And Industrial Research Organisation | Antiviral agents |
CZ304734B6 (cs) | 2000-07-21 | 2014-09-10 | Gilead Sciences, Inc. | Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu |
EP1903041B1 (de) | 2001-03-01 | 2015-02-18 | AbbVie Inc. | Polymorphe und andere kristalline Formen von Cis-FTC |
BRPI0210746B8 (pt) * | 2001-06-29 | 2021-05-25 | Inst Of Organic Chemistry And Biochemistry Ascr | derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação |
US7247621B2 (en) * | 2002-04-30 | 2007-07-24 | Valeant Research & Development | Antiviral phosphonate compounds and methods therefor |
US7214668B2 (en) * | 2002-05-13 | 2007-05-08 | Metabasis Therapeutics, Inc. | Phosphonic acid based prodrugs of PMEA and its analogues |
WO2003095665A2 (en) | 2002-05-13 | 2003-11-20 | Metabasis Therapeutics, Inc. | Pmea and pmpa cyclic producing synthesis |
EP1923063A3 (de) * | 2003-01-14 | 2009-04-08 | Gilead Sciences, Inc. | Zusammensetzungen und Verfahren für antivirale Kombinationstherapie |
ATE496056T1 (de) * | 2003-06-16 | 2011-02-15 | Acad Of Science Czech Republic | Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga |
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WO2005090370A1 (en) * | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
KR20070011451A (ko) | 2004-05-05 | 2007-01-24 | 예일 유니버시티 | 신규의 항바이러스 헬리오크산틴 유사체 |
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ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
US20090156545A1 (en) * | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
EP1868628B1 (de) * | 2005-04-08 | 2014-06-11 | Chimerix, Inc. | Verbindungen, zusammensetzungen und verfahren zur behandlung von pockenvirus-infektionen |
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US20140206678A1 (en) * | 2011-01-27 | 2014-07-24 | Kadmon Corporation, Llc | Inhibitors of mtor kinase as anti -viral agent |
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EP2794624B1 (de) | 2011-12-22 | 2019-05-15 | Geron Corporation | Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren |
WO2013167743A1 (en) | 2012-05-11 | 2013-11-14 | Akron Molecules Gmbh | Use of compounds for the treatment of pain |
WO2014068265A1 (en) | 2012-10-29 | 2014-05-08 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
WO2014143643A1 (en) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California, A California Corporation | Acyclic nucleoside phosphonate diesters |
US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
JP2017520545A (ja) | 2014-07-02 | 2017-07-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
KR102589658B1 (ko) | 2014-09-15 | 2023-10-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뉴클레오타이드 유사체 |
US10377782B2 (en) | 2015-09-15 | 2019-08-13 | The Regents Of The University Of California | Nucleotide analogs |
TWI740910B (zh) * | 2016-03-09 | 2021-10-01 | 美商艾洛斯生物製藥公司 | 非環抗病毒劑 |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU521577B2 (en) * | 1977-02-24 | 1982-04-22 | Wellcome Foundation Limited, The | 9-hydroxyethoxymethyl guanine phosphates |
US4287188A (en) * | 1977-02-24 | 1981-09-01 | Burroughs Wellcome Co. | Purine derivatives |
DE2909709A1 (de) * | 1979-03-12 | 1980-09-25 | Kailash Kumar Dr Gauri | Verfahren zur herstellung von nucleotidderivaten, neue nucleotidderivate und daraus hergestellte arzneimittel |
EP0105486A3 (de) * | 1982-09-30 | 1984-05-16 | Syntex (U.S.A.) Inc. | 1-Monophosphatester, 1,3-Bisphosphatester und cyklische Phosphatester von 9-(1,3-Dihydroxy-2-propoxymethyl)guanin als antivirale Mittel |
CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
IL72173A0 (en) * | 1983-06-24 | 1984-10-31 | Merck & Co Inc | Guanine derivatives,their preparation and pharmaceutical compositions containing them |
US4670424A (en) * | 1983-09-19 | 1987-06-02 | Merck & Co., Inc. | Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides |
US4590269A (en) * | 1984-03-29 | 1986-05-20 | Syntex (U.S.A.) Inc. | Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines |
US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
NZ222553A (en) * | 1986-11-18 | 1991-07-26 | Bristol Myers Co | Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions |
CA1330794C (en) * | 1987-03-27 | 1994-07-19 | Phillip Frost | Anti-viral compounds, dosage forms and methods |
-
1986
- 1986-07-18 CS CS865469A patent/CS264222B1/cs not_active IP Right Cessation
-
1987
- 1987-07-16 NZ NZ221100A patent/NZ221100A/xx unknown
- 1987-07-17 US US07/074,900 patent/US5142051A/en not_active Expired - Lifetime
- 1987-07-17 FI FI873165A patent/FI86856C/fi not_active IP Right Cessation
- 1987-07-17 AU AU75759/87A patent/AU600002B2/en not_active Expired
- 1987-07-17 DE DE8787110399T patent/DE3765864D1/de not_active Expired - Lifetime
- 1987-07-17 ES ES198787110399T patent/ES2036194T3/es not_active Expired - Lifetime
- 1987-07-17 DE DE1997175085 patent/DE19775085I2/de active Active
- 1987-07-17 DK DK373487A patent/DK170646B1/da not_active IP Right Cessation
- 1987-07-17 ZA ZA875283A patent/ZA875283B/xx unknown
- 1987-07-17 CA CA000542404A patent/CA1340856C/en not_active Expired - Lifetime
- 1987-07-17 AT AT87110399T patent/ATE57932T1/de active
- 1987-07-17 IE IE194487A patent/IE60117B1/en not_active IP Right Cessation
- 1987-07-17 EP EP87110399A patent/EP0253412B1/de not_active Expired - Lifetime
- 1987-07-17 IL IL83235A patent/IL83235A/xx not_active IP Right Cessation
- 1987-07-18 KR KR87007844A patent/KR950004179B1/ko not_active IP Right Cessation
- 1987-07-18 JP JP62179877A patent/JPH0822866B2/ja not_active Expired - Lifetime
- 1987-07-19 EG EG42/87A patent/EG18273A/xx active
- 1987-07-20 PT PT85354A patent/PT85354B/pt unknown
-
1990
- 1990-11-19 GR GR90400937T patent/GR3002534T3/el unknown
-
1994
- 1994-10-11 US US08/320,591 patent/US5641763A/en not_active Expired - Lifetime
-
1995
- 1995-03-28 US US08/412,398 patent/US5869467A/en not_active Expired - Lifetime
-
1997
- 1997-10-01 NL NL970036C patent/NL970036I2/nl unknown
- 1997-10-21 LU LU90155C patent/LU90155I2/fr unknown
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