DE19882037T1 - Hartgelatinekapsel, die im wesentlichen ölfreie pharmazeutische Zusammensetzungen enthält - Google Patents

Hartgelatinekapsel, die im wesentlichen ölfreie pharmazeutische Zusammensetzungen enthält

Info

Publication number
DE19882037T1
DE19882037T1 DE19882037T DE19882037T DE19882037T1 DE 19882037 T1 DE19882037 T1 DE 19882037T1 DE 19882037 T DE19882037 T DE 19882037T DE 19882037 T DE19882037 T DE 19882037T DE 19882037 T1 DE19882037 T1 DE 19882037T1
Authority
DE
Germany
Prior art keywords
capsule containing
pharmaceutical compositions
hard gelatin
gelatin capsule
containing essentially
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19882037T
Other languages
English (en)
Inventor
Armin Meinzer
Barbara Haeberlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26310891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19882037(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9701881.6A external-priority patent/GB9701881D0/en
Priority claimed from GBGB9702594.4A external-priority patent/GB9702594D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE19882037T1 publication Critical patent/DE19882037T1/de
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
DE19882037T 1997-01-30 1998-01-28 Hartgelatinekapsel, die im wesentlichen ölfreie pharmazeutische Zusammensetzungen enthält Ceased DE19882037T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9701881.6A GB9701881D0 (en) 1997-01-30 1997-01-30 Organic compounds
GBGB9702594.4A GB9702594D0 (en) 1997-02-07 1997-02-07 Organic compounds
PCT/EP1998/000453 WO1998033512A1 (en) 1997-01-30 1998-01-28 Oil-free pharmaceutical compositions containing cyclosporin a

Publications (1)

Publication Number Publication Date
DE19882037T1 true DE19882037T1 (de) 1999-12-16

Family

ID=26310891

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69826272T Revoked DE69826272T2 (de) 1997-01-30 1998-01-28 Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält
DE19882037T Ceased DE19882037T1 (de) 1997-01-30 1998-01-28 Hartgelatinekapsel, die im wesentlichen ölfreie pharmazeutische Zusammensetzungen enthält
DE29824679U Expired - Lifetime DE29824679U1 (de) 1997-01-30 1998-01-28 Pharmazeutische Zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69826272T Revoked DE69826272T2 (de) 1997-01-30 1998-01-28 Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE29824679U Expired - Lifetime DE29824679U1 (de) 1997-01-30 1998-01-28 Pharmazeutische Zusammensetzungen

Country Status (26)

Country Link
US (3) US6475519B1 (de)
EP (2) EP1331002A3 (de)
JP (2) JP2000516256A (de)
KR (3) KR20040004416A (de)
CN (2) CN1246058A (de)
AT (1) ATE275963T1 (de)
AU (1) AU737053B2 (de)
BR (1) BR9807528A (de)
CA (1) CA2278675A1 (de)
CY (1) CY2548B1 (de)
CZ (1) CZ295207B6 (de)
DE (3) DE69826272T2 (de)
ES (1) ES2229473T3 (de)
GB (2) GB2335854B (de)
HK (1) HK1027745A1 (de)
HU (1) HUP0001013A3 (de)
ID (1) ID26696A (de)
IL (2) IL130797A0 (de)
NZ (1) NZ336900A (de)
PL (1) PL190420B1 (de)
PT (1) PT988046E (de)
RU (1) RU2211047C2 (de)
SG (1) SG115386A1 (de)
SK (1) SK285019B6 (de)
TR (1) TR199901686T2 (de)
WO (1) WO1998033512A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
CN1246058A (zh) * 1997-01-30 2000-03-01 诺瓦提斯公司 包含环孢菌素a的无油药物组合物
CN1309414C (zh) * 1997-03-12 2007-04-11 艾博特公司 用于给予环孢菌素的亲水二元体系
GB2326337A (en) 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
EP0982035B1 (de) * 1998-08-18 2004-03-31 Panacea Biotec Limited Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger
GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
GB9912476D0 (en) 1999-05-28 1999-07-28 Novartis Ag Organic compounds
US7919113B2 (en) 1999-12-30 2011-04-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dispersible concentrate lipospheres for delivery of active agents
AR033711A1 (es) * 2001-05-09 2004-01-07 Novartis Ag Composiciones farmaceuticas
HU229505B1 (hu) * 2001-09-10 2014-01-28 Tibotec Pharm Ltd Eljárás hexahidrofuro [2,3-b]furán-3-ol elõállítására
AR038681A1 (es) * 2002-02-14 2005-01-26 Solvay Pharm Bv Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
US7101566B2 (en) * 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
GB2391471B (en) * 2002-08-02 2005-05-04 Satishchandra Punambhai Patel Pharmaceutical compositions
EP1603512A2 (de) * 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Neue cyclosporine
AU2004264958B2 (en) 2003-08-13 2010-04-15 Biocon, Ltd Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
WO2005053727A2 (en) * 2003-11-29 2005-06-16 Sangstat Medical Corporation Pharmaceutical compositions for bioactive peptide agents
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
EP1809656A4 (de) * 2004-09-29 2009-03-25 Amr Technology Inc Cyclosporinalkinanaloga und deren pharmazeutische anwendungen
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
JP2008515886A (ja) * 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
KR20080007580A (ko) 2005-04-12 2008-01-22 엘란 파마 인터내셔널 리미티드 사이클로스포린을 함유하는 나노입자형 조절 방출 조성물
US20060240051A1 (en) * 2005-04-26 2006-10-26 Singleton Andy H Eutectic blends containing a water soluble vitamin derivative
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008103712A2 (en) * 2007-02-20 2008-08-28 Bisco, Inc. Polymerizable dental pulp healing, capping, and lining material and method for use
EP2164466A1 (de) * 2007-06-01 2010-03-24 Novo Nordisk A/S Spontan dispergierbare vorkonzentrate mit einem peptidwirkstoff in einem festen oder halbfesten träger
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
RU2571857C2 (ru) 2008-03-18 2015-12-20 Ново Нордиск А/С Стабилизированные по отношению к протеазам ацилированные аналоги инсулина
SA109300195B1 (ar) 2008-03-28 2013-04-20 Astrazeneca Ab تركيبة صيدلانية جديدة مضادة للسرطان
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2018098501A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
HRP20221324T1 (hr) 2016-12-16 2022-12-23 Novo Nordisk A/S Farmaceutski pripravci koji sadrže inzulin

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE738604C (de) 1935-07-09 1943-08-23 Rudolf Degkwitz Dr Verfahren zur Herstellung von Hydrosolen mit waehlbarer Gestalt und waehlbarer Groesse der kolloiden Teilchen
CH240789A (de) 1942-01-28 1946-01-31 Reichstein Tadeus Dr Professor Verfahren zur Herstellung einer neuen Verbindung der Cyclopentanopolyhydrophenanthren-Reihe.
GB616190A (en) 1945-11-06 1949-01-18 Procter & Gamble Improvements in application of low temperature inter-esterification or alcoholysis to glycerides
FR1274354A (fr) 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1171125A (en) 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
US3813345A (en) 1971-08-05 1974-05-28 Vanguard Chem Co Inc Method of producing microcolloidal aqueous emulsions of unsaturated organic compounds
US3954967A (en) 1971-08-05 1976-05-04 Vanguard Chemical Company, Inc. Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds
US4073943A (en) 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
CH614931A5 (de) 1975-11-04 1979-12-28 Sandoz Ag
US4210581A (en) 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
US4146499A (en) 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
JPS53107408A (en) 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
DE2907460A1 (de) 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
CH641356A5 (en) 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
US4571926A (en) 1979-06-22 1986-02-25 Pneumatic Scale Corporation Apparatus for forming, filling and depositing filled bags into cartons
JPS6033429B2 (ja) 1980-04-28 1985-08-02 小野薬品工業株式会社 プロスタグランジン類似化合物
NZ199915A (en) 1981-03-11 1985-07-12 Unilever Plc Treating edible oils to raise melting point thereof
FR2502951B1 (fr) 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
BE895724A (fr) 1982-02-01 1983-07-28 Sandoz Sa Nouvelle utilisation therapeutique de la dihydrocyclosporine d
JPS58208215A (ja) 1982-05-31 1983-12-03 Sato Seiyaku Kk 脂溶性ビタミン配合油溶組成物
DE3225706C2 (de) 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3235612A1 (de) 1982-09-25 1984-03-29 Bayer Ag, 5090 Leverkusen Mikroemulsionen
DE3237814A1 (de) 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3315805A1 (de) 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
JPS6061535A (ja) 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
FR2553661B1 (fr) 1983-10-19 1985-12-20 Rhone Poulenc Sante Nouvelles microemulsions pharmaceutiquement acceptables
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4794000A (en) 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
EP0365044A3 (de) 1984-08-02 1990-08-22 Sandoz Ag Pharmazeutische Verwendung von (NVA)2-Cyclosporin
CH662944A5 (it) 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
DE3444893A1 (de) 1984-12-08 1986-06-12 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von fettsaeuremethylestern
JPS61280435A (ja) 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
JPS61249918A (ja) 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
JPS6224776A (ja) 1985-07-25 1987-02-02 Matsushita Electric Works Ltd 画像デ−タの圧縮方式
IL78929A0 (en) 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US5023271A (en) 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4797272A (en) 1985-11-15 1989-01-10 Eli Lilly And Company Water-in-oil microemulsions for cosmetic uses
SE8601624D0 (sv) 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
SE457693B (sv) 1986-07-01 1989-01-23 Drilletten Ab Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
CA1318589C (en) 1986-08-14 1993-06-01 Bernard Ecanow Drug delivery system
DE3629386A1 (de) 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
DE3707711A1 (de) 1987-03-11 1988-09-22 Hoechst Ag Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung
CA1301642C (en) 1987-03-30 1992-05-26 Howard Bernard Dawson Chemical formulations
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
JP2577049B2 (ja) 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
ES2059558T3 (es) 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
GB2206119B (en) 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US4835002A (en) 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
HU205010B (en) 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
US5756450A (en) 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
IL88076A (en) 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US4914188A (en) 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
EP0327280B1 (de) 1988-01-29 1992-03-18 Sankyo Company Limited Cyclosporin-Zusammensetzungen
CH679119A5 (de) 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US6007840A (en) 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
ES2052016T3 (es) 1988-09-29 1994-07-01 Shiseido Co Ltd Composicion emulsionada.
BE1003578A4 (fr) 1988-10-26 1992-04-28 Sandoz Sa Nouvelles compositions ophtalmiques a base d'une cyclosporine.
JPH0738771B2 (ja) 1989-01-17 1995-05-01 花王株式会社 液状食用油組成物
WO1990008537A1 (en) 1989-02-06 1990-08-09 Abbott Laboratories Pharmaceutical compositions for oral administration
CH679277A5 (de) 1989-02-09 1992-01-31 Sandoz Ag
US4996193A (en) 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
DD298351A5 (de) 1989-11-06 1992-02-20 Jenapharm Gmbh,De Verfahren zur herstellung einer carrierabhaengigen arzneiform
AU6785490A (en) 1989-12-18 1991-06-20 Kraft General Foods, Inc. Low-saturate edible oils and transesterification methods for production thereof
HU208491B (en) 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
FR2683225B1 (fr) 1991-10-31 1993-12-31 Gattefosse Sa Procede pour ameliorer une huile glycerolysee.
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
DE69307505T2 (de) 1992-05-13 1997-07-24 Sandoz Ag Opthalmische zusammensetzungen enthaltend ein cyclosporin
EP0589843B1 (de) * 1992-09-25 2001-11-28 Novartis AG Cyclosporin enthaltende pharmazeutische Zusammensetzungen
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
CZ291237B6 (cs) * 1993-04-20 2003-01-15 Novartis Ag Farmaceutický přípravek pro orální podání obsahující cyklosporin A
SI1033128T2 (sl) 1993-09-28 2012-02-29 Scherer Gmbh R P Izdelava mehke Ĺľelatinaste kapsule
DE4340781C3 (de) 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
EP0697214A1 (de) * 1994-07-19 1996-02-21 Vestar, Inc. Pharmazeutische Formulierungen mit liposomalem Cyclosporin
CN1121238C (zh) * 1994-11-03 2003-09-17 诺瓦蒂斯有限公司 口服施用的具有简单组成和高生物利用度的环孢菌素新制剂形式及其制造方法
KR0167613B1 (ko) * 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
EP0825849A1 (de) * 1995-05-19 1998-03-04 Abbott Laboratories Selbstemulgierbare arzneiformulierungen für lipophile arzneimittel
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5962019A (en) 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
CN1246058A (zh) * 1997-01-30 2000-03-01 诺瓦提斯公司 包含环孢菌素a的无油药物组合物
CN1309414C (zh) 1997-03-12 2007-04-11 艾博特公司 用于给予环孢菌素的亲水二元体系
US6008191A (en) 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
SG115386A1 (en) 2005-10-28
GB2335854B (en) 2001-04-25
JP2005225897A (ja) 2005-08-25
GB2335854A (en) 1999-10-06
GB2355195A (en) 2001-04-18
US20020119190A1 (en) 2002-08-29
TR199901686T2 (xx) 1999-09-21
US20040161458A1 (en) 2004-08-19
ID26696A (id) 2001-02-01
WO1998033512A1 (en) 1998-08-06
IL130797A0 (en) 2001-01-28
GB9917521D0 (en) 1999-09-29
RU2211047C2 (ru) 2003-08-27
PL334850A1 (en) 2000-03-27
PL190420B1 (pl) 2005-12-30
CN1679917A (zh) 2005-10-12
CZ295207B6 (cs) 2005-06-15
AU6214198A (en) 1998-08-25
JP2000516256A (ja) 2000-12-05
KR20050084502A (ko) 2005-08-26
CN1246058A (zh) 2000-03-01
HK1027745A1 (en) 2001-01-23
BR9807528A (pt) 2000-03-14
HUP0001013A2 (hu) 2000-10-28
GB2355195B (en) 2001-09-12
PT988046E (pt) 2004-12-31
NZ336900A (en) 2001-06-29
KR20040004416A (ko) 2004-01-13
DE29824679U1 (de) 2002-03-28
SK285019B6 (sk) 2006-04-06
US6723339B2 (en) 2004-04-20
CY2548B1 (en) 2008-07-02
ES2229473T3 (es) 2005-04-16
ATE275963T1 (de) 2004-10-15
US6475519B1 (en) 2002-11-05
EP0988046A1 (de) 2000-03-29
EP1331002A3 (de) 2004-01-14
AU737053B2 (en) 2001-08-09
DE69826272T2 (de) 2005-11-17
GB0024188D0 (en) 2000-11-15
HUP0001013A3 (en) 2004-10-28
GB2355195A8 (en) 2002-03-28
KR20000069900A (ko) 2000-11-25
IL130797A (en) 2006-08-01
DE69826272D1 (de) 2004-10-21
CA2278675A1 (en) 1998-08-06
SK102099A3 (en) 2000-01-18
EP1331002A2 (de) 2003-07-30
EP0988046B1 (de) 2004-09-15
CZ266399A3 (cs) 1999-10-13

Similar Documents

Publication Publication Date Title
DE19882037T1 (de) Hartgelatinekapsel, die im wesentlichen ölfreie pharmazeutische Zusammensetzungen enthält
PT712631E (pt) Emulsoes multiplas contendo ciclosporina
DE69403057T2 (de) Zusammensetzung, die bei peroraler verabreichung eine mikroemulsion bildet
DE69926862D1 (de) Kosmetische oder dermo-pharmazeutische zusammensetzung in form von hydrophoben perlen und herstellungsverfahren
ATE236628T1 (de) Fenofibrathaltige neue galenische arzneizusammensetzungen und ihre verwendung
CA2072509A1 (en) Cyclosporin emulsion compositions for oral administration
CA2106827A1 (en) Pharmaceutical compositions containing cyclosporins
MY117765A (en) Cyclosporin-containing soft capsule preparations.
EP0895808A3 (de) Lösungsvermittler und daraus hergestellte Hydrosolzusammensetzung
JPS56127308A (en) Blood-coagulation factor 8 pharmaceutical
MY118614A (en) Cyclosporin-containing pharmaceutical compositions

Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: BREUER, M., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80

8110 Request for examination paragraph 44
8131 Rejection