DE2329753A1 - PRODUCTS FOR ORAL AND DENTAL CARE - Google Patents

Description

Dipl.-In ₉ . H. MITSCHERLICH Ο - 8 MONKS 22

Dipl.-In ₉ . K. GUNSCHMANN St.ln.dorf.tr «B. 10

Dr. rr not. W. KÖRBER W (oeii) · »« «

Dipl.-In ₉ . J. SCHMIDT-EVERS

PATENT LAWYERS lo. September 197

Dr.Kö / ko

Patent application P 23 29 753.2

National Patent Development Corporation Oral and dental care preparations

The present invention relates to oral cleaning and dental care. An object of the invention is to provide

j of compositions for use as mouthwash or Mouth washes that can also remove plaque and tooth decay.

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Another goal * is to create a toothpaste from these Compositions »

The combination according to the invention is suitable for use with the removal of dental plaque and tooth decay use aqueous solutions that contain the following: as component (i) at least one oxidizing compound, which is a chlorite ion, a chlorate ion, a perchlorate ion, or persulfate ion or contains a peroxide, organic peracid, ozone or chlorine dioxide; (ii) a (nitrogen-containing) amine compound which Can chelate metal ions and a hydroxyl group, a carboxyl group, a sulfonic acid group or N-acyl group contains.

Suitable chlorite, chlorate and perchlorate compounds are, for example, alkali metal chlorites such as sodium chlorite, Potassium chlorite, lithium chlorite, rubidium chlorite and cesium perchlorate.

Suitable persulfates are, for example, ammonium persulfate, sodium persulfate, potassium persulfate, lithium persulfate, rubidium persulfate, Cesium persulfate, a suitable peroxide being, for example, hydrogen peroxide. Organic too Peroxides can be used, e.g. B. benzoyl peroxide acetyl peroxide, methyl ethyl ketone peroxide, cumene peroxide, cumene hydroperoxide. Peracetic acid, perpropionic acid, pervaleric acid, perisobutyric acid and perbutyric acid can be used as peracids be used.

To react with the oxidizing agent and to achieve a buffer effect, either inorganic compounds

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fertilize, like ζ. B. sulfamic acid, or organic compounds which contain two to 11 carbon atoms are used, z. B., glycine, sarcosine, alpha-aminisobutyric acid, taurine, 2-amine ethanol, N-acetylglycine, alanine, beta-alanine, serine, Phenylalanine, norvaline, leucine, isoleucine, proline, hydroxyproline, omega-aminoundecanoic acid, aspartic acid, glutamic acid, Glutamine, asparagine, valine, tyrosine, threonine, cysteine, cystine, methionine, glutamine, tryptophan, histidine, arginine, Lysine, alpha-amine butyric acid, gamma-amine butyric acid, alpha-epsilon-diaminopimelic acid, Ornithine, hydroxylysine, anthranilic acid, p-aminbenzoic acid, sulfanilic acid, orthanilic acid, phenylsulfamic acid, Amine propane sulfonic acid, 2-amine ethanol, 2-amine propanol, Diethanolamine, Ethylenediarainetraacetic acid (EDTA) and Mtriltriacetic acid.

The effect of these solutions on dental plaque and dental caries is based on the ability of the above-mentioned ions to interact with proteins to react.

Concentrations of the above-mentioned oxidizing agents within of the range from 0.001 to 0.050 moles. incl. are preferred, with such solutions being most effective seem.

Puncture solutions will work at any molar ratio of the nitrogen-containing compound to any of the above Oxidizing agents obtained, but the preferred range between 3 and 10 mol including the nitrogen-containing Compound per mole of one of the oxidizing agents

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lies. Such a small amount as B. one mole of the nitrogenous Compound per Hol oxidizer can be used.

The tooth decay can be eliminated even faster if the solution is in the form of a simple jet stream or as a pulsating jet stream is applied.

The solutions to be used for the treatment are preferably freshly prepared for each individual pail.

Such solutions can be used by simply removing the part of the mouth or teeth that are to be treated for example, like washing with mouthwash, whereby they are used for essentially immediate removal of the tooth ^ - covering are effective. Accordingly, is a daily mouthwashing routine effective for such treatment.

According to a further feature of the present invention, however, the removal of dental plaque and tooth decay can be done even faster by using the solutions under attrition or abrading conditions, for example in the form of simple high-speed jet streams or by brushing or rubbing in the presence of abrasive particles.

Even better results are achieved when the solutions be used under erosion conditions, such as B. by the application of the solutions in the form of pulsating jets, so that the plaque and the tooth decay are stressed

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or is stressed and breaks as a result of mechanical fatigue.

The solutions of the present invention lead to the achievement of the following Goals:

1. They eliminate carious injuries

2. They dissolve and eraul the dental plaque

3. As a result of the dissolution of the dental plaque, they help to prevent the development or formation of lime or tartar and prevent tooth decay,

example 1

A bad tooth that is being prepared for sealing.

One of the solutions enumerated below is applied either in the form of a jet at 50-200 pounds / square inch or as a pulsating stream with a pressure range of 0 ^ 200 pounds / square inch and at a frequency of 100-1200 pulses / minute through a hypodermic needle Calibration size of 10-33 supplied in a carious area. The tooth is cleaned up within 2 to 10 minutes from the substantially caries. All data for the concentrations and solutions which are listed below relate to mol / liter. The teeth treated were extracted teeth. All solutions were freshly made up and used within an hour at approximately body temperature. Dental plaque is removed in a similar way.

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Example · I _t Part A

NaGlO,

NaOH

NaCl

Amine linkage

0.004 0.025 0.025 0.025 glycine 0.008 0.05 0.05 0.05 glycine 0.016 0.10 0.10 0.10 glycine 0.008 0.04 0.05 0.04 taurine 0.008 0.06 0.05 0.06 sarcosine 0.008 0.10 0.05 0.05 glutamic acid 0.008 0.04 0.05 0.04 lysine 0.008 0.05 0.05 0.05 urea 0.008 0.05 0.05 0.05 sulfamic acid LiClO ₀ LiOH LiCl Amine linkage 0.008 0.05 0.05 0.05 glycine KClO ₂ KOH KCl Amine linkage 0.008 0.05 0.05 0.05 glycine 0.008 0.05 0.05 0.05 2-amine ethanol RbClO ₂ RbOH RbCl Amine compound 0.008 0.05 0.05 0.05 glycine CsClO ₂ CsOH CsCl Amine linkage 0.008 0.05 0.05 0.05 glycine

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Example I, part B.

NaClO ^ NaOH NaCl Arain connection 0.004 0.025 0.025 0.025 glycine 0.008 0.05 0.05 0.05 glycine 0.016 0.10 0.10 0.10 glycine 0.008 0.05 0.05 0.05 taurine 0.008 0.04 0.05 0.04 sarcosine 0.008 0.12 0.05 0.06 glutamic acid 0.003 0.04 0.05 0.04 lysine 0.008 0.05 0.05 0.05 urea 0.008 0.05 0.05 0.05 sulfamic acid LiClO ^ LiOH LiCl Amine linkage 0.008 0.05 0.05 0.05 glycine KClO ^ KOH KCl Amine compound 0.008 0.05 0.05 0.05 glycine 0.008 0.05 0.05 0.05 2-amine ethanol RbCKK RbOH RbCl Amine compound 0.008 0.05 0.05 0.05 glycine CsCKK CsOH CsCl Amine compound 0.008 0.05 0.05 0.05 glycine

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Example I ₁ part C

NaClO, j NaOH NaGl Amine linkage 0.004 0.025 0.025 0.025 aiycin 0.008 0.05 0.05 0.05 glycine 0.016 0.10 0, 10 0.10 glycine 0.008 0.04 0.05 0.04 taurine 0.008 0.06 0.05 0.06 sarcosine 0.008 0.10 0.05 0.05 glutamic acid 0.008 0.04 0.05 0.04 lysine 0.008 0.06 0.05 0.06 urea 0.008 0.05 0.05 0.05 sulfamic acid LiClO ₇₁ LiOH LiCl Amine linkage - ι 4
0.008 0.05 0.05 Q05 glycine. KClO ₄ KOH KCl Amine linkage 0.008 0.05 0.05 0.05 glycine 0.008 0.05 0.05 0.05 2-amine ethanol RbClO ₁ RbOH RbCl .. Amine linkage 0.008 0.05 0.05 0.05 glycine CsClO ,, CsOH CsCl Amine compound -. ■ 4
0.008 0.05 0.05 0.05 glycine

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Example I, part D.

Na ₀ S ₂ O ₈ NaOH NaCl Amine linkage 0.004 0.025 0.025 0.025 clycine 0.008 0.05 0.05 0.05 glycine 0.016 0.10 0.10 0.10 glycine 0.008 0.05 0.05 0.05 taurine 0.008 0.04 0.05 0.04 sarcosine 0.003 0.12 0.05 0.06 glutamic acid 0.003 0.04 0.05 0.04 lysine 0.008 0.05 0.05 0.05 urea 0.008 0.04 0.05 0.04 sulfamic acid Li ₂ S ₂ O ₈ LiOH LiCl Am i n connection 0.008 0.05 0.05 0.05 glycine K ₂ S ₂ O ₈ KOH KCl Ami n connection 0.008 0.05 0.05 0.05 glycine 0.008 0.05 0.05 0.05 2-amine ethanol Hb ₂ S ₂ O ₈
0.008 RbOH
0.05 RbCl
0.05 Amine compound
0.05 glycine Cs S 0 CsOH CsCl Amine compound 0.008 0.05 0.05 0.05 glycine

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Example. I, part E.

H ₂ O ₂ NaOH NaCl Amine compound 0.008
CH-.G000H 0.05
NaOH 0.05
NaCl 0.05 glycine
Amine linkage 0.008
O ₃ 0.05
NaOH 0.05
NaCl 0.05 glycine
Amine compound 0.008
ClOo 0.05
NaOH 0.05
NaCl 0.05 glycine
Amine compound 0.008
Example 2 0.05 0.05 0.05 glycine Typical oral detergent composition

As one of the Mundwaschpreparat in Example 1 aufgefuhs ¹ · ten combinations can be used. By cleaning the mouth with these solutions for about 1 minute every day, plaque will be removed, which also promotes the elimination of the build-up of lime or tartar.

Example 3 Toothpaste combinations

One of the compositions listed in Example 1 is used as a toothpaste _{after production with SiO 2.}

Another toothpaste formulation can be seen below,

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Example 4

Glycerin 47 parts

Water 7.3 parts

Saccarin (sodium salt) 0.04 parts

extracted liters of lime 20.8 parts

Magnesium carbonate 13.3 parts Soap (powder, neutral, white) 0.85 parts

Gum tragacanth powder 0.76 parts

Glycine 5 parts

Chewing sulfate 3 parts

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Claims (7)

Claims 1. Agent for the treatment of the oral cavity and the teeth, characterized in that it consists of an aqueous solution with consists of the following components: (1) an oxidizing agent selected from the group consisting of a Chlorite ion, chlorate ion, perchlorate ion, persulfate ion, Peroxide, organic peracid, ozone and chlorine dioxide is made up, and (2) a nitrogen-containing compound. 2. Composition according to claim 1, characterized in that the nitrogen-containing compound is an amine which is derived from the Group selected from sulfamic acid and organic It is made up of nitrogen compounds that have 2 to 11 carbon atoms and have a hydroxyl group, a carboxylic acid group, a Contain sulfonic acid group or an N-acyl group. 3. Means according to claim 2, characterized in that the solution has a pH of 8 to 12. 4. Means according to claim 3, characterized in that the Oxidizing agent is present in a concentration of o.ool to o.o5 mol / liter and that the amine is present in an amount of 3 to Io moles per mole of oxidizing agent is present. 5. Agent according to claim 2, characterized in that the oxidizing agent is alkali metal chlorate, alkali metal perchlorate, Alkali metal chlorite, ammonium or alkali metal persulfate, Hydrogen superoxide, a peralkanoic acid with 2 to 5 carbon atoms, Ozone or chlorine dioxide. 309850/1232 6. Means according to claim 5, characterized in that 2 da amine glycine, N-acetylglycine, sarcosine, lysine, glutamine-0 acid, taurine, 2-amine ethanol, sulfamic acid, or ethylene-0 is dianine tetraacetic acid. I. 7. Means according to claim 2, characterized in that - 1 solid filler is present in an amount sufficient to make the solution paste-like. The patent attorney 309850/1232