DE2551992A1 - DOSED INJECTION FROM RESERVOIRS - Google Patents

Description

Dr med, Wolfgang Wagner, 1 Berlin 27 (West), Klosterfelder Weg 29

Nationality: FRG

Title: Dosed Injection from Storage Containers. Introduction:

The invention relates to the field of medical technology, specifically to injection technology.

State of the motor-driven infusion pumps with automatic control

Technique: the infeed speed have been in the last few years Medicine has been introduced. A multiple spray gun for the Intracutaneous treatment is known: “A separation of medicine and Air in the medicine bottle already saw a German Reich patent Before, metering pumps are particularly related to the Drug nebulization commonly used. Intravenous tube injection should be used in conjunction with the ultrasonic Doppler plicator (P 2314367.1) find use.

Task: To be subcutaneous, intramuscular and intravenous injection by simplifying handling and reducing labor and material costs

Solution: The injection by sucking the skin into the cannula (suction injection, German P 2244758.1,1972, withdrawn by me) avoids the risk of reaching nerves or bones or injecting them into vessels during the subcutaneous injection The dosing device should make syringe manipulations superfluous, even in the clinical area, as only the cannulas have to be changed. ' The novelty consists in the connection of medicine storage containers with dosing devices for the mentioned areas of application in addition to the auxiliary devices. The Ai ^v zneibewbewegung from the storage container is expediently done by pressure, in particular pneumatically transmitted, with separation of the propellant gas from the medicine.

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Description of the first embodiment:

FIG. 1 shows a two-chamber metering device ring in connection with a medicine bottle with merabran-connected ventilation. The dosage is set using a spindle (l) with a right-hand and left-hand thread. The air above the drug, into which the filling tube (5) is immersed, is limited by the casing (6) and is connected to the ventilation space via the opening (9), the drug space via the filling tube with the dosing chamber (ll), which is closed by the non-return valve (lft) and the valve sleeve (l3) actuated by the pressure of the syringe / The prerequisite for the commissioning of the device is the release of the rigid connection between the various cylinder caps on the bolt (2) via fixed pistons and the actuation of the Air cylinder cap (3) as a pump up to the opening of the valve (4) under load in the filling tube. For start-up, the cylinder cap movements are coupled again via the spindle, so that the amount of air in the medicine bottle corresponding to the amount of medicine removed is inserted into the elastic casing of various wall thicknesses to facilitate the filling of the space - is pumped in from one end, while the non-return valve (7) prevents the air from escaping through the ventilation pipe (8 ) prevented. The pump function of the air cylinder cap is made possible by the check valve (to), the drug delivery from the Dosiorkdirnnci * through the check valve (12) after opening the valve sleeve (l3) by pressure on the syringe cone (l't) while lowering the dosing cylinder cap (l5) ~ · After the dosing chamber has been emptied, the dosing chamber cylinder is held in place by the toothed grid (l6). The dosing can be read off on a scale (l7).
Description of the second embodiment:

Figure 2 represents, for example, a single-chamber metering device before using already _Ga sdru.ck feestehender drug container. In FIG. 2a, the gas pressure is effective on the medication located inside through a sleeve (6) surrounding the wall of the bottle with compressed gas between the sleeve and the wall of the bottle. The gas envelope surrounds

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also the short filling tube attachment (5). In Figure 2b is by gas pressure In the case of a cylindrical medicine container, a piston (18) is driven forward against the medicine in the direction of the outflow tube.

The function of the metering device (Figure 2) sets a metering setting on the piston (19) by means of the edge I screw (20) ahead, Wbei a screw sleeve (2l) is displaceable just above the filling pipe (5). The upper edge of the knurled screw limits the upward movement of the dosing cylinder cap (15); each inner edge actuates a spring mechanism via a nose with a steep drop in connection with a metering scale to make the metering setting audible and palpable. The piston rotation during metering is prevented by a groove (22) between the piston tube (23) and the filling tube. The liquid filling the dosing chamber can only take place if the dosing cylinder cap the dosing piston rests and after through the closed check valve (25) and the stopper (26) the resilient and by means of Sheath protected needle (27) over the orifice of the syringe cone the slip valve (25) in the dosing piston has opened The friction delay caused by the guide ring (28) on the valve cone closes the valve is so late that the largest fill volume in the Dosing chamber may have flowed in. An intermediate ring (2'i) secures the Freedom of piston tube movement. The membrane (29) protects the dosing chamber from contamination,

In the example of Figure 2c, the skin is by means of a suction cylinder (35) pulled up in connection with a water jet pump (36). The injection bottle is sealed in a sliding inner cylinder (37) which, before the injection, engages with a groove in a spring catch (38). The suction bottle with dosing device is dispensed. and attached cannula towards the skin If the cannula is blocked by the stop (40), the dosing cylinder is finally lowered so that the drug flows out.

FIG. 2d shows a dosing device similar to the one just mentioned shown. The inflow from the filling pipe (5) through the piston (l9) is triggered via the valve (30) by lowering the slide sleeve (3l) the cylinder caps and downpipe over the fastening

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loosens the cylinder caps together with the filling pipe over the fastening clip (32) be held by the Ayznoi bottle. The height adjustment dosing of the piston takes place via the tendon thread (21) on the Cylinder cap (20) when the axles are attached by cutting blades on the Filling tube in the stopper and guide pin and guide channel between the worm thread and the piston tube (for dosing).

In Figure 2e, the valve (30) for the flow of medicament in. The metering chamber Lied inside the dosing flask. After setting the dosage (like above) is done by turning the oval dosing cylinder cap (l5) and thus the dosing piston with the valve plate fixed in the valve (30) an opening of the valve plate with such an im Valve seat brought to cover. After the medication has taken effect, the metering piston is returned to its starting position by the spring (33). Figure 2f shows a bracket labeled "Morning" on one end and "Evening" on the other. The difference between the two ends is even easier to determine that one end is round, the others have an angular shape. The clamp is used to hold two dosing devices or syringe barrels, their confusion is excluded. There is also a necessary pre-commitment between the dosing devices and the Dichtuiifisknppon for the Cannula adapter «

Figure 2g shows a detail of a modification of Example 2e. The valve seat of the valve (30) lies centrally on the surface of the metering piston (19) and is held by the tension spring (95). The eccentric The disc (96) facing the dosing piston has an oino notch for the passage of the valve cone (valve plate). After setting the dosage, the screw (97) is turned and with it the disk against the spring (33) via an angular pin in the angular central bore of the disc. After the valve cone due to the overpressure in The storage vessel is lifted into the notch of the disc, becomes its Rotation prevents until a pressure equalization between the pressure storage tank and dosing chamber is established (the valve cone is now pulled back into the seat by the spring, and the disc re-locks Rotation by the spring (33) the movement of the valve cone). The Dre-

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Rotation by the spring (33) the movement of the valve cone). The rotation of the disc can also take place via a serrated edge strip on the disc and a toothed edge within the dosing cylinder (15), s /

A,

Description of the third embodiment:

In Figure 3, an embodiment is shown in which the dosage takes place via a gear pump as a metering pump, the revolutions is limited via a liquid meter with adjustable speed limitation, as is known in the art. In the cannula hub a bore is provided, into which an air-free hollow body (42) is inserted in a sealed manner, which (via a manual valve) connects to the inside of the cannula contacts. The membrane (43) inside the cannula prevents backflow, but is activated when the Jland lever (44) destroyed via a wedge, which also closes the hollow body. A slide is then operated via the hand lever, which the flow rate from the dosing pump (4l) is adjustable and limited and metering pump are connected by means of a bayonet lock. The drug inflow takes place via a container (45), the membrane (46) of which via a The reducing valve is driven from the gas bottle (47). The detail A makes the suction function to the test Cannula position (in the vein) clearly, the magnification of Λ zo the Processes during the injection. The cut B-C orlüntavt the function of the slide. In the example in FIG. 3a, a piston is advanced in the medicine container by a spring (48).

Figure ya shows an example of the use of a dosing pump for administering several drugs. The Ayzncibehrilter (45) are housed in a Spoicher (50) which is equipped with a thomostat-controlled cooling device (98) in the lower part. In the upper part there is a distiller (55), the stopcocks are shown for \ ^r er§infachung as manual valves, but as elektroniechanische valves via a control unit automatically (electronically) usually actuated Vierdon. After two distillation of the water introduced via the filler neck at (54) via the condensation coils (55), it collects in the water container (56), the piston of which is from the motor-driven compressor

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in the water container (56), the piston of which is from the motor-operated compressor (57) is driven. The compressor also drives the medicine in the containers (4!>). Each medicine container has a unit (5l) with it two electromagnetic valves (Figure 3c). The water hose valve (53) regulates the further transport to the water supply hose (58), the drug supply valve (59) the drug delivery and the Venting the compressor pressure. Before changing the dispenser bottle the valve outlets are connected by a flushing pipe (60) and both valves via a circuit in the control unit in the reversed position as shown, so that after steam supply water pipes and valves are cleaned from the still. The storage tanks are either on a rail (99) Suspended, slidable and height-adjustable on the ceiling under weight ballaace for doctor's office use or for that Clinic on Wheels additionally with an accumulator device (100) for uninterrupted power supply and with a shelf (10l) for Accessories and single syringes are provided (3j) .The dosing pump (41) leading hose unit consists of two hoses (Figure 3d) Medicinal supply hose (6l), which is connected to the medicinal supply valve (39) Dosing pump and the water supply hose (5B), which is connected to the Water hose valve (53j3c) is filled. The dosing pump is on mechanical double check valve (62) upstream, here still upstream the bayonet lock with the metering pump assigned to the Zufulirschläuchcn. The predominance of pressure at one end of the hose leads to the actuation of the double piston (63) and thus to the opening of the respective opening to the dosing pump, while the other hose to the dosing pump is blocked will. The piston dimensions get an effective preponderance of the Water supply. The counting unit (64) on the metering pump is equipped with a wiping contact (65) which generates a control pulse for each gear wheel rotation to the control unit, so that the dosage can be adjusted there according to principles customary in the art. FIG. 3e shows the equipment of the piston in the medicine container (45) not an inner piston (66), which at the displacement by spring-loaded locking

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pins (67) is prevented. When the switch sleeve (68) hits open, follow up When the contents of the medicine container are consumed, the locking pins and thus the movement of the inner piston are released. About the plunger the plug (69), which sits loosely there, is inserted into the drug delivery tube introduced and from there by the gas pressure through the recess (70) driven further on the inner piston.

Figure 3f shows the union of two hose units with metering devices that lead to a common cannula hub (7l), so that any dose of two medicines can be injected at the same time. The grip sleeve (72) takes the dosing pump and hose ends

and relieves that from the slider

like a holding bridge

subsequently changed

According to FIG. 3g, the metering device can also be connected directly to the medicine bottle. After the medicine has been used up, a ball (74) embedded in a sleeve (73) can be pressed in via a hose opening in the storage vessel. After connecting the metering device to the water supply (78), the ball separates the drug and water. A drug supply tube can also be dosed towards the cannula without a storage vessel, which can be useful for smaller amounts of drugs. FIG. 3b illustrates an application in the case of intramuscular suction injection. A suction line from the compressor causes the downward movement of the Innon cylinder (37) and finally the vacuum above the skin is released by moving the air supply sleeve (75) in the interior of the outer fairy cylinder (35) after the cannula has penetrated the skin. The cannula device inside at blocking lateral rotation by guide pin and -rinne by the force of the downward movement of the Innencylinders in the influence of the Sogschlauches, so that the diaphragm is drawn (43) in place of the hollow body in Fig J. If there is no blood backflow, the valve slide sleeve {76) is moved on the outer cylinder via the manual switch (44) in such a way that the suction effect on the inside of the cannula is interrupted and the slide is actuated for dosing (injection). The support sleeve (77) can be adjusted in height via a thread on the outer cylinder (to regulate the penetration depth).

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retroactively changed

3k

In Figure-3ϊ * a detail of a cannula is shown, which by means of a lever can be raised and fixed in position in the selected position during the cannula insertion by pressing on the r ^ ster (lO2) will. In the example below, there is a hose-like connection to the joint on the cannula, which is made in the manner of modern fracture splinting or vacuum pack is fixed in position by suction on an elastic granule filling. drawings and descriptions serve only as examples of other solutions by means known in the art.

Description of the fourth example solution:

In the example of Figure 4, a disposable cannula is shown, which in the Holding cone (79) has an elastic sheath (80) which during a Negative pressure (before use) appears drawn inside the cannula. The tip of the cannula lies within an elastic stopper (8l). A sleeve between the cannula cone and the carrier piece of the Stopper ensures that the cannula shaft is clean (83) is removed before use. An elastic fiber ring (103) supports drug storage. When metering via one of the devices according to Examples 1 to 3, the pressure of the syringe cone on the stopper of the cannula shaft and the cannula tip breaks through the stopper membrane fills the sheath (80). After dosing, the cannula tip is back behind the cover of the stopper membrane. For injection If the cannula is lowered through the stopper, which rests on the skin, the sheath is emptied by pressing on it. FIG. 4a shows an application of the disposable cannula. The Agzneiweg overflows from the pressure accumulator supply bottle (45) the check valve (25) and support piece (82), wonn pressure on the Check valve is exerted from above, and further into the sheath (80). The cannula cone was previously over a (not shown in FIG ) Holding shell (84) in the outer cylinder (l5) of a syringe introduced, the piston (19) in the threaded sleeve (23) adjustable in depth is on the outer cylinder according to the dosing scale. The emptying takes place by the free movement of the syringe towards the syringe cone.

koibens. 609832/0584

kolbcns "

In Figure 4Ti a pressurized storage bottle (45) with a metering device via an adapter (85) with the cone of a commercially available one Syringe connected.

In FIG. 4c, the metering takes place inside canisellar around the spindle anchored in the base plate (86). formed by the lowering of the cover plate (87) against a spring and also ensure the sealing of the retaining cone. In Figure 4d, an example is given in which the valve plate of the non-return valve (30) before the drug escapes from a pressure storage bottle in a sleeve with openings in the beer cylinder wall or is attached centrally above the outlet opening of a pressure storage cylinder (+88) is sealed by an elastic plug (89) and carries the plate-like valve seat. The drug can only exit through the cannula tip if it has pierced the stopper and the Check valve has been opened by pressing the filler neck. The cannula cover (bag) has a non-return valve inside, the sicjj opens to the filling and wears out due to overpressure in the bull. During the injection, the slide, which can be moved on the cannula, causes the plate-like ring (90) by pressing against suction (9l) of the check valve s opening.

FIG. 4e shows a dosing cylinder, the interior of which is evacuated, while the cannula tip is sealed within a stopper. The piston downward movement is prevented by a pin (92) in the piston rod. A second locking pin (93) is inserted in a hole made in the piston rod in accordance with the various metering settings and in the one which corresponds to the selected metering. Now you can pull the first pin towards the first, the piston lowers until it locks on the second locking pin. With the support (105) removed, the bulb tip is inserted into a drug supply for filling or brought into a sealed connection with it. The second locking pin (93) is also sucked for the injection. _609832/0684

FIG. 4f shows a syringe cylinder as in example 4e with a filling nipple on the wall, which can be connected to a suction with a hose. After the cylinder has been evacuated, the piston with the piston rod is lowered to the metering setting via the lateral opening in the cylinder wall as in Example 4e.
Complement:

In Figure 3, the flutter valve (104) pre-secures the metering pump Reflux.

-free-

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Claims (1)

- 11 PATENT CLAIMS! / l, y facilities for pre-dosed injection from storage containers, characterized, that devices for variable pre-dosing by means of pumps of the piston-cylinder type (including bellows) with at least partially automatic (caused by pre-stored or electrically generated force) lifting or pushing movement or by means of rotary pumps or electronically controlled flow limitation immediately before a supply that exceeds the single dose or at least vcr the main supply or in connection with a drug supply stored in a movable cavity connection or in or in front of such, when the drive-generating or transmitting power source is separated from the drug within the drug storage container or in the movable cavity connection or from the power source in general and the intended temporary connection of the dosing device with the cannula or with a hollow space that is intended to be connected to a cannula, insofar as this is provided by pre-stored or hydraulic or pneumatic or electric The force generated is caused by the dosing device and limited by the dosing device when certain drugs are consumed too soon , or by external cavity delimitations, namely variably predeterminable, for subcutaneous or intravenous or intramuscular injection. 2 «devices according to claim 1, characterized in that where pressure storage cylinders are used. 3. Devices according to Claims 1 and 2 ', characterized in that that pressure storage bottles in connection with dosing devices 609832/0584 or with adapter devices that connect to a Allow dosing device. 4. Devices according to claim 1 and 2, characterized in that that the (pressure bottle has only one opening or openings only on one side. 5. Devices according to claim 1 and 2, characterized in that that the kill nozzle is firmly connected to the container or is part of it. 6. Devices according to claim 1 and 2, characterized in that dejß the single doses are prepared in containers with the cannula are in communication. 7. Devices according to claim 1 and 6, characterized in that that cylindrical containers are used. 8. devices according to claim 1 and 6, characterized thereby, that sack-shaped containers are used. 9. devices according to claim 1, 7, 8, characterized in that that the dosage by changing the size (limitation ") of the Container can be adjusted. + fixed 10. Devices according to claim 1.7 »8, characterized in that the dosage can be determined by varying the size of the container. g _Q g ₈ 3 ₂ / Q 5 8 4 11. devices according to claim 1, characterized in that that the cannula tip is protected in the rest position behind a membrane or a stopper in front of and. after use. + except for Gebr. 12. devices according to claim 1, characterized in that that the cannula shaft is protected by a membrane when not in use. 13. devices according to claim 1, characterized in that that an elastic ring acts as a kiagge in the sackcloth. + a + valve 14. devices according to claim 1,8,9 »10, characterized in that that lip-shaped seals or conical seals are effective against the cannula. 15. devices according to claim!, Characterized. that pistons or membranes serve to port movement of the drug. 16. devices according to claim 1, characterized in that that the volume replacement takes place through the stopper or an opening of the medicine container. 17. devices according to AÜsprucb 1 and 16, characterized in that that an air chamber is connected to the dosing chamber. 18. Devices according to claim 1 and 17, characterized in that that the volume replacement takes place within the envelope, which drug and air separates. 609832/0584 19 «Devices according to claim 1 and 18, characterized in that that the sheath for the volume replacement has different elasticity in different sections. 20. devices according to claim 1, 2, 3, characterized in that that the influence of the drug in the dosing chamber via a of externally controlled valve takes place. 21. Devices according to claim I, 2,3j4,5j, characterized in that that the influence of the drug into the metering chamber takes place through a valve which is actuated by turning the metering cylinder will. 22o devices according to claim 1, 2,3,4,5jdadurcb. marked, that the dosing cylinders are transparent. 23. facilities according to claim I, 2,3j4,5 »7jdadureh, that connecting devices are used with distinguishable Ends for two containers or containers with dosing devices. 24.Einrichtungen according to claim!, Characterized in that the drug supply consists of an at least partially movable Hohlraumve
is injected. chen cavity connection and a + a 25. Devices according to claims 1 and 24, characterized in that that hoses are used as cavity connections. 609832/0584 26. Devices according to claim 1, characterized in that that gear pumps are used. or rotary pumps. 27. Devices according to claim 1, characterized in that that electronic controls are used in particular for flow control (dosing). 28 Devices according to Claim 1, characterized in that that electromagnetic valves are used. 29. Devices according to claim 1, characterized in that that liquid-controlled valves are used. 30. devices according to claim 1, characterized in that in which a cooling device is provided or with a cooling device « 31. Devices according to claim 1, characterized in that that distillation devices are used. 32. devices according to claim 1, characterized in that that signaling devices are used to make the dosage audible and / or palpable 33 »Devices according to claims 1 and 32, characterized in that 'that unites; Spring snap device is used. 6 0 9832/0584 Jk. Devices according to claims 1 to 10 and 30, 32, 33}, characterized in that welehe by attaching or connecting with surface changes or designs the side orientation on palpable or visible Way to enable. 35. devices according to claim. 1 to 10 and 21 to 25, characterized in that that devices for connecting the same with sealing caps be used. 36. devices according to Ajjspruch 1, characterized in that that Heinigungshohlwege be used. 37. devices according to claim 1, characterized in that that dosing devices in connection with the main supply or in front of a hose or a cavity connection with the cannula or used as a cannula. 38. devices according to claim 1, characterized in that that dosing devices are used directly in front of the cannula attachment. 39 «Equipment according to claim 1, characterized in that that a separating device is provided between gas or liquid (water) and medicament flow from the medicament container or Water container or the cavity connection leads to the cannula, especially one that is after the main supply has been used up is operated. 609832/0584. _ 17 - 40 devices according to claim 1, characterized in that that the inflow velocity into the body can be regulated. 41. devices according to claim 1, characterized in that that a suction or a lean cavity inlet for testing the seat of the cannula tip in the body. 42. devices according to claim 1, characterized in that that devices exert suction on the skin, be it in a functional connection. 43 »Devices according to claim 1, characterized in that that protective devices against a backflow in particular from the area of the body can be used. 44.Einrichtungen according to claim 1, characterized in, and that the pressure is caused by a pressurized gas membrane. 45 «Devices according to claim 1 and 2, characterized in that that the pressure is created by a compressor. 46. devices according to claim 1 and 2, characterized in that that the metering device is connected to or into an injection device separately from the drug supply container built-in. 609832/0584 47e device according to claim 1, characterized in that that the combination of at least two metering devices allows independent metering even during the injection. 48. devices according to claim 1, characterized in that that devices on the cannula attachment cone or on the dosing device allow an upward movement (kink) of the cannula, at least Ms fixed for the puncture. 49. Devices according to claim 1, characterized in that that a suction can be interrupted by special devices. 50. devices according to claim 1, characterized in that that the filler neck via a check valve or a drug pressure vessel or a metering device through a sealing membrane or a plug is closed. 51. devices according to claim 1, characterized in that that the filler neck itself is moved to the check valve of a metering device or a pressure storage container actuate· Apparatus according to Claim 1, characterized in that B ^ rdßnßji · containers are used which make air-poor ^{+ that} and the volume of which can be subsequently adapted to the dosing volume. 609832/0584 53 «Devices according to claim 1 and 52, characterized in that that the change in the dosing volume by blocking a piston movement takes place. 54o devices according to claim 1, characterized in that that a valve sleeve in the filler neck is moved by the back- check valve to the pressure storage tank or to the dosing device to operate. 55 «devices according to claim 1, 52j53} dadurcl: · characterized in that the V
+ acting that the vacuum is generated through a temporary valve opening. 56. devices according to claim 1, characterized in that that valve devices are used inside or very close to the cannula. 57 «Devices according to claim 1, characterized in that that cannula necks are turned inside out when not in use 58, devices according to claim 1, characterized in that that a valve mechanism is located within the kaiiülsackes. 59 »Devices according to claim 1, characterized in that that parts of the pressure storage container or dosing devices are enclosed by protective membranes or connected to them are" 609832/0584