DE2755751A1 - IMPLANT FOR BONES, JOINTS OR TOOTH ROOTS - Google Patents
IMPLANT FOR BONES, JOINTS OR TOOTH ROOTSInfo
- Publication number
- DE2755751A1 DE2755751A1 DE19772755751 DE2755751A DE2755751A1 DE 2755751 A1 DE2755751 A1 DE 2755751A1 DE 19772755751 DE19772755751 DE 19772755751 DE 2755751 A DE2755751 A DE 2755751A DE 2755751 A1 DE2755751 A1 DE 2755751A1
- Authority
- DE
- Germany
- Prior art keywords
- implant
- hydroxyapatite
- bones
- mixture
- joints
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
Description
u.Z.: M 480
Case : 5594-6uZ: M 480
Case: 5594-6
SUMITOMO CHEMICAL COMPANY, LTD.
Osaka, JapanSUMITOMO CHEMICAL COMPANY, LTD.
Osaka, Japan
"Implantat für Knochen, Gelenke oder Zahnwurzeln""Implant for bones, joints or tooth roots"
Es ist bekannt, daß in der Prothetik verwendete Teile, insbesondere solche, die als künstliche Knochen, Gelenke oder Zahnwurzeln eingesetzt werden, ausreichende mechanische Festigkeit, Stoßfestigkeit und Lebensdauer aufweisen müssen. Außerdem müssen sie für das lebende Gewebe verträglich sein und dürfen keinen schädlichen Einfluß auf den lebenden Körper ausüben. Es wurden bereits verschiedene Stoffe zur Herstellung von Implantaten für Knochen, Gelenke oder Zahnwurzeln verwendet, jedoch wurde bisher noch kein Material gefunden, das allen Anforderungen an derartige Implantate genügt.It is known that parts used in prosthetics, in particular those used as artificial bones, joints or tooth roots, sufficient mechanical strength, Must have shock resistance and durability. In addition, they must be compatible with the living tissue and must not have any harmful influence on the living body exercise. Various substances have already been used to manufacture implants for bones, joints or tooth roots used, but so far no material has been found that meets all the requirements for such implants.
Infolgedessen werden viele Implantate durch Verbindung von zwei oder mehr Stoffen hergestellt. Solche kombinierte Implantate sind beispielsweise in der DT-OS 20 08 010 beschrieben. Danach werden Implantate für Knochen- oder Zahnteile durch Plasma-Aufdampfen eines eutektischen Gemisches von Tricalciumphosphat und Tetracalciumphosphat auf einen Formkern hergestellt, der ausreichende mechanische Festigkeit aufweist. Der Kern kann aus Metali, keramischem Material oder Kunststoff bestehen. Nach dem Aufdampfen wird die erhaltene Schicht aus dem eutektischen Gemisch in feuchter Atmosphäre auf 10000C erhitzt, wobei sich das eutektische Gemisch inAs a result, many implants are made by combining two or more substances. Such combined implants are described in DT-OS 20 08 010 , for example. Then implants for bone or tooth parts are produced by plasma vapor deposition of a eutectic mixture of tricalcium phosphate and tetracalcium phosphate on a mandrel which has sufficient mechanical strength. The core can consist of metal, ceramic material or plastic. After the vapor deposition, the layer obtained from the eutectic mixture is heated to 1000 ° C. in a moist atmosphere, the eutectic mixture in
809825/08 5809825/08 5
Hydroxyapatit umwandelt, der eine ausgezeichnete Verträglichkeit mit lebendem Gewebe aufweist.Hydroxyapatite converts, which has an excellent tolerance with living tissue.
Der Erfindung liegt die Aufgabe zugrunde, Implantate für Knochen, Gelenke oder Zahnwurzeln mit ausreichender mechanischer Festigkeit und hervorragender Verträglichkeit mit lebenden Geweben sowie ein verbessertes Verfahren zu ihrer Herstellung zu schaffen. Diese Aufgabe wird durch die Erfindung gelöst. Die Erfindung betrifft somit den in den Ansprüchen gekennzeichneten Gegenstand.The invention is based on the object of providing implants for bones, joints or tooth roots with sufficient mechanical Strength and excellent compatibility with living tissues, as well as an improved method for their manufacture to accomplish. This object is achieved by the invention. The invention thus relates to that characterized in the claims Object.
Die Erfindung wird nachstehend anhand der Zeichnung erläutert. Die Zeichnung zeigt schematisch teilweise im Aufriß eine Ausführungsform eines erfindungsgemäßen Kieferimplantats, wobei A) die Vorderansicht und B) die Seitenansicht darstellt.The invention is explained below with reference to the drawing. The drawing shows schematically, partially in elevation, an embodiment of a jaw implant according to the invention, wherein A) shows the front view and B) shows the side view.
1 bedeutet einen Keramikkern und 2 eine thermisch aufgedampfte Schicht aus einem Gemisch von keramischem Material und Hydroxyapatit. 1 denotes a ceramic core and 2 a thermally vapor-deposited layer made of a mixture of ceramic material and hydroxyapatite.
Als keramisches Material zur Verwendung in vorliegender Erfindung kommen alle bekannten, zum thermischen Aufdampfen geeigneten Stoffe in Frage, die üblicherweise zur Behandlung von Metalloberflächen nach einem thermischen Aufdampfverfahren zur Erzielung von Korrosionsbeständigkeit oder Verschleißfestigkeit verwendet werden. Spezielle Beispiele sind Metalloxide, wie Aluminiumoxid, Titandioxid, Zirkoniumdioxid, Siliciumdioxid, Zinndioxid, Phosphorpentoxid, Calciumoxid, Bortrioxid oder ihre Gemische. Vorzugsweise wird Aluminiumoxid verwendet.The ceramic material for use in the present invention is any of the known, suitable for thermal vapor deposition Substances in question, which are usually used for the treatment of metal surfaces by a thermal vapor deposition process be used to achieve corrosion resistance or wear resistance. Specific examples are metal oxides, such as aluminum oxide, titanium dioxide, zirconium dioxide, silicon dioxide, tin dioxide, phosphorus pentoxide, calcium oxide, boron trioxide or their mixtures. Alumina is preferably used.
Erfindungsgemäß kann sowohl synthetischer als auch aus dem lebenden Organismus gewonnener Hydroxyapatit (Bio-hydroxyapatit) verwendet werden. Synthetischer Hydroxyapatit kann beispielsweise durch Umsetzung von Ca-(PO^)p mit CaO im Überschuß bei hohen Temperaturen von 900 bis 13000C in Gegenwart von Wasserdampf (trockenes Herstellungsverfahren) oder durchAccording to the invention, both synthetic hydroxyapatite and hydroxyapatite (bio-hydroxyapatite) obtained from the living organism can be used. Synthetic hydroxyapatite can, for example, by reacting Ca- (PO ^) p with CaO in excess at high temperatures of 900 to 1300 0 C in the presence of steam (dry manufacturing process) or by
L 80982b/08b L 80982b / 08b
Γ ΠΓ Π
Umsetzung von Calcium (0,5 Mol/Liter) mit einer Lösung von Phosphorsäure in Wasser bei einer Temperatur von 37°C bis zu einem pH-Wert von 7i1 bis 7» ^- (nasses Herstellungsverfahren) hergestellt werden. Der Bio-hydroxyapatit kann aus den Knochen oder Zähnen verschiedener Tiere, wie Rinder, Pferde, Hunde, Hühner oder Kaninchen, gewonnen werden. Dazu wird beispielsweise das harte Gewebe von Knochen oder Zähnen an der Luft auf etwa 8000C erhitzt und danach in siedendes Äthylendiamin eingetaucht, wobei die darin enthaltenen organischen Bestandteile gelöst und entfernt werden. Die organischen Bestandteile werden danach mit Sauerstoff, der in einer Niedertemperatur-Veraschungsvorrichtung in ein Plasma umgewandelt wurde, verbrannt.Reaction of calcium (0.5 mol / liter) with a solution of phosphoric acid in water at a temperature of 37 ° C to a pH of 7i1 to 7 »^ - (wet manufacturing process). The bio-hydroxyapatite can be obtained from the bones or teeth of various animals such as cattle, horses, dogs, chickens or rabbits. For this purpose, the hard tissue of bone or teeth, for example, heated in air at about 800 0 C and then immersed in boiling ethylene diamine, wherein the organic components contained therein dissolved and removed. The organic components are then burned with oxygen that has been converted to plasma in a low temperature incinerator.
Der erfindungsgemäfi eingesetzte Keramikkern kann nach einem der bekannten Verfahren zur Herstellung von prothetischen keramischen Teilen hergestellt v/erden. Beispielsweise kann ein Keramikkern mit ausreichender mechanischer Festigkeit durch Schlickergießen oder Pressen eines keramischen Stoffes zu einer bestimmten Form, vorzugsweise mit einer kalten isostatischen Presse und anschließendes Erhitzen des geformten keramischen Gegenstandes für etwa 5 Stunden auf eine Temperatur von 1000 bis 20000C erhalten werden. Nach oder während des Erhitzens kann der Keramikkern mechanisch bearbeitet werden, beispielsweise durch Sandblasen, Schleifen, Einkerben oder Schneiden, wenn die endgültige Gestalt dps Keramikkerns kompliziert ist oder eine rauhe Oberfläche erforderlich ist. Der Keramikkern kann in verschiedener Form, beispielsweise als Stift, Schraube, Blatt, Anker, Platte oder Netz ausgebildet sein. Die besondere Form des Keramikkerns soll so festgelegt sein, daß er sich dem lebenden Gewebe des Wirtes anpaßt.The ceramic core used according to the invention can be produced by one of the known methods for producing prosthetic ceramic parts. For example, a ceramic core with sufficient mechanical strength can be obtained by slip casting or pressing a ceramic material into a specific shape, preferably with a cold isostatic press and then heating the shaped ceramic object for about 5 hours to a temperature of 1000 to 2000 ° C. After or during the heating, the ceramic core can be mechanically worked, for example by sandblowing, grinding, notching or cutting, if the final shape of the ceramic core is complicated or a rough surface is required. The ceramic core can be designed in various forms, for example as a pin, screw, blade, anchor, plate or mesh. The particular shape of the ceramic core should be determined so that it adapts to the living tissue of the host.
Die Schicht aus einem Gemisch von keramischem Material und Hydroxyapatit kann durch ein thermisches Aufdampfverfahren, d.h. Aufblasen und Laminieren eines durch Verbrennung oderThe layer of a mixture of ceramic material and hydroxyapatite can be produced by a thermal vapor deposition process, i.e. inflating and laminating one by incineration or
L 809825/0854 L 809825/0854
mit elektrischer Energie geschmolzenen oder nahezu geschmolzenen Gemisches, vorzugsweise durch ein Plasma-Aufdampf-Verfahren, d.h. durch Aufbringen des Gemisches in Form eines Plasmastrahls (elektromagnetischer Fluidzustand mit Über-Schallgeschwindigkeit) bei hoher Temperatur, die durch einenmixture melted or almost melted with electrical energy, preferably by a plasma vapor deposition process, i.e. by applying the mixture in the form of a plasma jet (electromagnetic fluid state with over-sonic speed) at high temperature caused by a
werften Lichtbogen erzeugt wird, hergestellte Das mit der Schicht aus dem Gemisch überzogene Erzeugnis kann als solches als Implantat verwendet werden oder vorher an der Luft oder im Vakuum auf eine Temperatur von 900 bis 13000C erhitzt werdon. Das Mischungsverhältnis von keramischem Material und Hydroxyapatit ist nicht kritisch. Gewöhnlich enthält das Gemisch jedoch 10 bis 90 Gewichtsprozent, vorzugsweise 30 bis 70 Gewichtsprozent Hydroxyapatit und als Rest keramisches Material. Die Schicht aus dem Gemisch wird gewöhnlich in einer Dicke von höchstens 1000 yu, vorzugsweise von 100 bis 300 ,u aufgebracht. Eine derart aufgedampfte Schicht hat ausreichende mechanische Festigkeit und außerdem hervorragende Affinität zu lebendem Gewebe und haftet fest an dem Keramikkern.shipyards arc is generated manufactured, The coated with the layer of the mixture product may be used as such as an implant or werdon previously heated in the air or under vacuum at a temperature from 900 to 1300 0 C. The mixing ratio of ceramic material and hydroxyapatite is not critical. Usually, however, the mixture contains 10 to 90 percent by weight, preferably 30 to 70 percent by weight of hydroxyapatite and the remainder ceramic material. The layer of the mixture is usually applied in a thickness of at most 1000 microns, preferably from 100 to 300 microns. Such a vapor-deposited layer has sufficient mechanical strength and also has an excellent affinity for living tissue and adheres firmly to the ceramic core.
Neben der hervorragenden Affinität zu lebendem Gewebe und der ausreichenden mechanischen Festigkeit besitzt das erfindungsgemäße Implantat folgende Vorteile: Das Implantat ist mit dem Wirtsgewebe ohne die Venvendung eines Bindemittels wie Knochenzement fest verbunden, da das V/irtsgewebe in die Mikroporen der thermisch aufgedampften Schicht und um die unebene Oberfläche des Implantats wächst, und Hydroxyapatit aus der Schicht in das Gewebe absorbiert und gleichzeitig durch neu gewachsenes Knochengewebe ersetzt wird. Dadurch wird das Implantat im Wirtsgeviebe noch stärker fixiert.In addition to the excellent affinity for living tissue and the adequate mechanical strength, the inventive The implant has the following advantages: The implant is connected to the host tissue without the use of a binding agent such as bone cement firmly connected because the host tissue enters the micropores the thermally vapor deposited layer and grows around the uneven surface of the implant, and hydroxyapatite from the Layer is absorbed into the tissue and at the same time replaced by newly grown bone tissue. This will make the implant more firmly fixed in host cattle.
Das erfindungsgemäße Implantat kann in verschiedenen Teilen des lebenden Körpers als künstlicher Knochen, Gelenk oder Zahnwurzel, beispielsweise in Zähnen, Knochen oder Schleimhäuten oder unter der Knochenhaut verwendet werden. 35The implant according to the invention can be used in various parts of the living body as an artificial bone, joint or Tooth roots, for example in teeth, bones or mucous membranes or under the periosteum. 35
Das Beispiel erläutert dip Erfindung.The example illustrates the invention.
809825/Q85A809825 / Q85A
-Ji.-Ji.
Ein Keramikkern wird nach folgendem Verfahren hergestellt : Aluminiumoxid mit einer Reinheit von 99*99% und einem Teilchendurchmesser von höchstens 10/u wird unter einem Druck vonA ceramic core is manufactured using the following process: Aluminum oxide with a purity of 99 * 99% and a particle diameter of at most 10 / u is under a pressure of
2
1000 kg/cm in einer kalten isostatischen Presse geformt.2
1000 kg / cm molded in a cold isostatic press.
Danach wird die Oberfläche mechanisch aufgerauht. Der geformte Kern wird sodann 5 Stunden auf eine Temperatur von 17000C erhitzt.The surface is then mechanically roughened. The shaped core is then heated to a temperature of 1700 ° C. for 5 hours.
Unter Verwendung einer Plasma-Aufdampf-Vorrichtung wird eine Argon-V/asserstoff-Plasmastrahlflamme erzeugt (Stromstärke des Lichtbogens: 500 A). Damit wird ein Gemisch von 7O/o H apatit (als farbloses Pulver hergestellt nach dem trockenenUsing a plasma vapor deposition apparatus, a Argon / hydrogen plasma jet flame generated (current intensity of Arc: 500 A). This gives a mixture of 7O / o H apatit (produced as a colorless powder after dry
2 Herstellungsverfahren, spezifisches Gewicht: 3*2 g/cm , Teilchengröße : höchstens 100,u) und J>0 Gewichtsprozent Aluminiumoxid (Metcopulver Hr. 105) in einer durchschnittlichen Dicke von etwa 200 ,u auf die äußere Oberfläche des KeramikkQrns thermisch aufgedampft.2 manufacturing process, specific gravity: 3 * 2 g / cm, particle size: not more than 100, u) and J> 0 weight percent alumina (Metcopulver Hr 105) in an average thickness of about 200, and on the outer surface of Keramikk Q rns thermally. vaporized.
Das erhaltene Implantat wird in das Schienbein eines Schweines eingepflanzt und 3 Monate röntgenfluoreskopisch untersucht. Hierbei zeigt sich, daß sich ein faseriges Knochengewebe um das Implantat gebildet hat. Außerdem werden bei der mikroskopischen Untersuchung keine abnormen Symptome festgestellt. The implant obtained is implanted in the shin of a pig and examined by X-ray fluorescopy for 3 months. This shows that fibrous bone tissue has formed around the implant. In addition, the microscopic examination found no abnormal symptoms.
8Ü0825/08548Ü0825 / 0854
Claims (5)
Case: 55946uZ: M 480 (Vo / Ra / H)
Case: 55946
Osaka, JapanSUMITOMO CHEMICAL COMPAiTY 1 LTD.
Osaka, Japan
*- 809825/0854 J he follows.
* - 809825/0854 J.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP51151725A JPS5946911B2 (en) | 1976-12-16 | 1976-12-16 | implant |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2755751A1 true DE2755751A1 (en) | 1978-06-22 |
Family
ID=15524911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19772755751 Ceased DE2755751A1 (en) | 1976-12-16 | 1977-12-14 | IMPLANT FOR BONES, JOINTS OR TOOTH ROOTS |
Country Status (5)
Country | Link |
---|---|
US (1) | US4223412A (en) |
JP (1) | JPS5946911B2 (en) |
DE (1) | DE2755751A1 (en) |
FR (1) | FR2374019A1 (en) |
GB (1) | GB1550575A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2840064A1 (en) * | 1978-09-14 | 1980-03-20 | Scheicher Hans | Prodn. of hydroxy:apatite contg. material - by calcining tooth or bone, useful for filling bones, insertion of implants etc. |
US4237559A (en) * | 1979-05-11 | 1980-12-09 | General Electric Company | Bone implant embodying a composite high and low density fired ceramic construction |
EP0082621A1 (en) * | 1981-12-18 | 1983-06-29 | COLLAGEN CORPORATION (a California corporation) | Implantable bone prosthesis |
DE3527136A1 (en) * | 1984-08-31 | 1986-03-13 | Bristol-Myers Co., New York, N.Y. | IMPLANT AND METHOD FOR PRODUCING THE SAME |
US4631031A (en) * | 1984-04-12 | 1986-12-23 | Richter Ernst Juergen | Artificial dental prosthesis |
US4880610A (en) * | 1988-04-20 | 1989-11-14 | Norian Corporation | In situ calcium phosphate minerals--method and composition |
US5047031A (en) * | 1988-04-20 | 1991-09-10 | Norian Corporation | In situ calcium phosphate minerals method |
US5053212A (en) * | 1988-04-20 | 1991-10-01 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
US5129905A (en) * | 1988-04-20 | 1992-07-14 | Norian Corporation | Methods for in situ prepared calcium phosphate minerals |
US5178845A (en) * | 1988-04-20 | 1993-01-12 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
US5330826A (en) * | 1990-08-13 | 1994-07-19 | Mcdonnell Douglas Corporation | Preparation of ceramic-metal coatings |
DE19901271A1 (en) * | 1999-01-15 | 2000-07-20 | Harald Erle | Implant for reconstruction of (especially cranial) bone defects comprises aluminum oxide and/or zirconium oxide ceramic coated with tricalcium phosphate or hydroxylapatite for good biocompatibility |
DE19945529A1 (en) * | 1999-09-23 | 2001-04-05 | Anton Bohmann | Implant for reconstructing bone defects, useful in e.g. cranial, especially facial, area, consists of highly pure alumina and/or zirconium oxide bioceramic with coating having bone affinity, e.g. tricalcium phosphate or hydroxyapatite |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5550349A (en) * | 1978-10-09 | 1980-04-12 | Kureha Chemical Ind Co Ltd | Dental compound material |
JPS608985B2 (en) * | 1979-08-10 | 1985-03-07 | 富士写真フイルム株式会社 | Crystallized glass and its manufacturing method |
FR2484246A1 (en) * | 1980-06-17 | 1981-12-18 | Europ Propulsion | PROCESS FOR PRODUCING BIOACTIVE COATINGS ON BONE PROSTHESES, AND PROSTHESES THUS OBTAINED |
CH640129A5 (en) * | 1980-10-20 | 1983-12-30 | Cbs Biotechnic Sa | ENDO-BONE IMPLANT IN BIOCERAMICS FOR DENTAL MEDICINE. |
JPS58118746A (en) * | 1982-01-07 | 1983-07-14 | 株式会社ニコン | Dental implant and production thereof |
US4673355A (en) * | 1982-10-25 | 1987-06-16 | Farris Edward T | Solid calcium phosphate materials |
CA1247960A (en) | 1983-03-24 | 1989-01-03 | Hideki Aoki | Transcutaneously implantable element |
DE3316801A1 (en) * | 1983-05-07 | 1984-11-08 | Friedrichsfeld Gmbh, Steinzeug- Und Kunststoffwerke, 6800 Mannheim | SEMI-IMPLANT |
CH665551A5 (en) * | 1984-03-06 | 1988-05-31 | Werner Hans Dr Med De Moermann | BLANK FOR THE MANUFACTURE OF DENTAL TECHNOLOGY MOLDED PARTS. |
JPS60256462A (en) * | 1984-05-31 | 1985-12-18 | 今西 久是律 | Production of artificial bone material such as implant material |
DE3421056A1 (en) * | 1984-06-06 | 1985-12-12 | Feldmühle AG, 4000 Düsseldorf | JAW IMPLANT FOR THE ADMISSION OF A DENTAL SPARE CARRIER |
JPS6131163A (en) * | 1984-07-23 | 1986-02-13 | 京セラ株式会社 | Ceramic living body prosthetic material and its production |
US4722870A (en) * | 1985-01-22 | 1988-02-02 | Interpore International | Metal-ceramic composite material useful for implant devices |
JPS61178356A (en) * | 1985-02-05 | 1986-08-11 | Toray Ind Inc | Stenter |
DE3676741D1 (en) * | 1985-05-20 | 1991-02-14 | Sumitomo Chemical Co | METHOD FOR PRODUCING ENDOSSAL IMPLANTS. |
US4818559A (en) * | 1985-08-08 | 1989-04-04 | Sumitomo Chemical Company, Limited | Method for producing endosseous implants |
JPH0669482B2 (en) * | 1985-08-08 | 1994-09-07 | 住友化学工業株式会社 | Intraosseous implant manufacturing method |
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-
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- 1976-12-16 JP JP51151725A patent/JPS5946911B2/en not_active Expired
-
1977
- 1977-12-14 DE DE19772755751 patent/DE2755751A1/en not_active Ceased
- 1977-12-15 FR FR7737855A patent/FR2374019A1/en active Granted
- 1977-12-15 US US05/860,958 patent/US4223412A/en not_active Expired - Lifetime
- 1977-12-15 GB GB52243/77A patent/GB1550575A/en not_active Expired
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2840064A1 (en) * | 1978-09-14 | 1980-03-20 | Scheicher Hans | Prodn. of hydroxy:apatite contg. material - by calcining tooth or bone, useful for filling bones, insertion of implants etc. |
US4237559A (en) * | 1979-05-11 | 1980-12-09 | General Electric Company | Bone implant embodying a composite high and low density fired ceramic construction |
EP0082621A1 (en) * | 1981-12-18 | 1983-06-29 | COLLAGEN CORPORATION (a California corporation) | Implantable bone prosthesis |
US4631031A (en) * | 1984-04-12 | 1986-12-23 | Richter Ernst Juergen | Artificial dental prosthesis |
DE3527136A1 (en) * | 1984-08-31 | 1986-03-13 | Bristol-Myers Co., New York, N.Y. | IMPLANT AND METHOD FOR PRODUCING THE SAME |
DE3527136C2 (en) * | 1984-08-31 | 1989-04-13 | Bristol-Myers Co., New York, N.Y., Us | |
US4880610A (en) * | 1988-04-20 | 1989-11-14 | Norian Corporation | In situ calcium phosphate minerals--method and composition |
US5047031A (en) * | 1988-04-20 | 1991-09-10 | Norian Corporation | In situ calcium phosphate minerals method |
US5053212A (en) * | 1988-04-20 | 1991-10-01 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
US5129905A (en) * | 1988-04-20 | 1992-07-14 | Norian Corporation | Methods for in situ prepared calcium phosphate minerals |
US5178845A (en) * | 1988-04-20 | 1993-01-12 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
US5330826A (en) * | 1990-08-13 | 1994-07-19 | Mcdonnell Douglas Corporation | Preparation of ceramic-metal coatings |
DE19901271A1 (en) * | 1999-01-15 | 2000-07-20 | Harald Erle | Implant for reconstruction of (especially cranial) bone defects comprises aluminum oxide and/or zirconium oxide ceramic coated with tricalcium phosphate or hydroxylapatite for good biocompatibility |
DE19945529A1 (en) * | 1999-09-23 | 2001-04-05 | Anton Bohmann | Implant for reconstructing bone defects, useful in e.g. cranial, especially facial, area, consists of highly pure alumina and/or zirconium oxide bioceramic with coating having bone affinity, e.g. tricalcium phosphate or hydroxyapatite |
Also Published As
Publication number | Publication date |
---|---|
JPS5946911B2 (en) | 1984-11-15 |
GB1550575A (en) | 1979-08-15 |
FR2374019B1 (en) | 1982-02-05 |
US4223412A (en) | 1980-09-23 |
JPS5375209A (en) | 1978-07-04 |
FR2374019A1 (en) | 1978-07-13 |
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