DE2946723C2 - - Google Patents

Info

Publication number
DE2946723C2
DE2946723C2 DE2946723A DE2946723A DE2946723C2 DE 2946723 C2 DE2946723 C2 DE 2946723C2 DE 2946723 A DE2946723 A DE 2946723A DE 2946723 A DE2946723 A DE 2946723A DE 2946723 C2 DE2946723 C2 DE 2946723C2
Authority
DE
Germany
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2946723A
Other versions
DE2946723A1 (de
Inventor
Tomaso Lausanne Ch Sozzi
Alfred Orbe Ch Schrenk
Marcel Tolochenaz Ch Buehler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Original Assignee
Societe des Produits Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA filed Critical Societe des Produits Nestle SA
Publication of DE2946723A1 publication Critical patent/DE2946723A1/de
Application granted granted Critical
Publication of DE2946723C2 publication Critical patent/DE2946723C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
DE19792946723 1978-12-05 1979-11-20 Einen mikroorganismus enthaltende mikrokugel und verfahren zu ihrer herstellung Granted DE2946723A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1239278A CH637297A5 (fr) 1978-12-05 1978-12-05 Microbille comprenant un microorganisme et son procede de fabrication.

Publications (2)

Publication Number Publication Date
DE2946723A1 DE2946723A1 (de) 1980-06-19
DE2946723C2 true DE2946723C2 (de) 1987-04-09

Family

ID=4382571

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792946723 Granted DE2946723A1 (de) 1978-12-05 1979-11-20 Einen mikroorganismus enthaltende mikrokugel und verfahren zu ihrer herstellung

Country Status (10)

Country Link
US (1) US4332790A (de)
AU (1) AU526326B2 (de)
BE (1) BE880027A (de)
CH (1) CH637297A5 (de)
DE (1) DE2946723A1 (de)
ES (1) ES486575A1 (de)
FR (2) FR2443247A1 (de)
IT (1) IT1164075B (de)
MX (1) MX6497E (de)
SE (1) SE447540B (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004004030A1 (de) * 2004-01-27 2005-08-18 Mars Inc. Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung
DE102012008271A1 (de) 2012-04-23 2013-10-24 Human Nutrition Gmbh Kleingebäck zur Unterstützung der Gewichtsreduktion

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4919929A (en) * 1984-02-01 1990-04-24 Stolle Research & Development Corporation Mammal immunization
SE463598B (sv) * 1984-11-08 1990-12-17 Chemical Dynamics Sweden Ab Preparat, avsett att oeka vidhaeftningen av bakterier till mag-tarmkanalen hos maenniskor och djur, samt ett framstaellningsfoerfarande foer detta
US5597564A (en) * 1986-08-28 1997-01-28 Enzacor Properties Limited Method of administering a microgranular preparation to the intestinal region of animals
US5356625A (en) * 1986-08-28 1994-10-18 Enzacor Properties Limited Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
WO1990001335A1 (en) * 1988-08-02 1990-02-22 Borody Thomas J Treatment of gastro-intestinal disorders
AU640349B2 (en) * 1988-08-02 1993-08-26 Borody, Thomas J Dr Treatment of gastro-intestinal disorders
US5443826A (en) * 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
JP2571874B2 (ja) * 1989-11-06 1997-01-16 アルカーメス コントロールド セラピューティクス，インコーポレイテッド タンパク質マイクロスフェア組成物
US5213810A (en) * 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
ES2100951T3 (es) * 1990-12-31 1997-07-01 Pioneer Hi Bred Int Bacterias microencapsuladas en acido graso con disco giratorio, secadas.
US5292657A (en) * 1990-12-31 1994-03-08 Pioneer Hi-Bred International, Inc. Process for preparing rotary disc fatty acid microspheres of microorganisms
US5599556A (en) * 1991-12-31 1997-02-04 Abbott Laboratories Prolamine coatings for taste masking
ES2124060T5 (es) * 1992-07-06 2002-12-16 Nestle Sa Bacteria lactica.
EP0577903B1 (de) * 1992-07-06 1997-12-17 Societe Des Produits Nestle S.A. Lactobacillus Acidophilus enthaltende Antigastritis-Mittel
EP0654273A1 (de) * 1993-11-18 1995-05-24 Harry H. Leveen Pharmazeutisches Produkt und Behandlungsverfahren
US5733568A (en) * 1993-12-03 1998-03-31 Lafor Laboratories Limited Micro-encapsulated lactobacilli for medical applications
ZA942302B (en) * 1993-12-03 1995-09-29 Lafor Lab Ltd Viracidal bactericidal and spermicidal vaginal suppository
EP0858267A1 (de) * 1995-11-02 1998-08-19 Ed. Haas Nährmittel Gesellschaft m.b.H. Probiotisch wirksame formulierungen
ATE298363T1 (de) * 1996-07-09 2005-07-15 Nestle Sa Verfahren zur sprühtrocknung
US20060116330A1 (en) * 1997-07-08 2006-06-01 The Iams Company Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose
US8563522B2 (en) * 1997-07-08 2013-10-22 The Iams Company Method of maintaining and/or attenuating a decline in quality of life
US20020035071A1 (en) * 1997-07-08 2002-03-21 Josef Pitha Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites
CA2413109C (en) * 2000-06-26 2007-11-27 Martek Biosciences Boulder Corporation Improved methods of incorporating polyunsaturated fatty acids in milk
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US20050266069A1 (en) * 2002-09-06 2005-12-01 Simmons Donald L Stable probiotic microsphere compositions and their methods of preparation
US7517681B2 (en) * 2003-01-29 2009-04-14 Biogaia Ab Selection and use of lactic acid bacteria for reducing dental caries and bacteria causing dental caries
US20050100559A1 (en) * 2003-11-07 2005-05-12 The Procter & Gamble Company Stabilized compositions comprising a probiotic
US8894991B2 (en) * 2003-12-19 2014-11-25 The Iams Company Canine probiotic Lactobacilli
US7785635B1 (en) * 2003-12-19 2010-08-31 The Procter & Gamble Company Methods of use of probiotic lactobacilli for companion animals
US8877178B2 (en) * 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
US20050152884A1 (en) * 2003-12-19 2005-07-14 The Procter & Gamble Company Canine probiotic Bifidobacteria globosum
US20050158294A1 (en) * 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
WO2006130187A1 (en) * 2005-05-31 2006-12-07 The Iams Company Feline probiotic lactobacilli
PL1885383T3 (pl) * 2005-05-31 2017-06-30 Iams Europe B.V. Kocie probiotyczne bifidobakterie
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
BRPI0808391A2 (pt) 2007-02-01 2014-07-08 Lams Company Método para diminuir a inflamação e o estresse em um mamífero, mediante o uso de antimetabólitos de glicose, abacate ou extratos de abacate.
BE1018007A5 (fr) * 2008-02-21 2010-03-02 Van Lidth De Jeude Jehan Lienart Enrobage de microorganismes.
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
DK2381799T3 (en) * 2009-01-27 2018-10-22 Probiotical Spa PROBIOTIC SUPPLEMENT WITH CHOCOLATE TASTE
IT1400821B1 (it) * 2009-03-09 2013-07-02 Probiotical Spa Sospensione oleosa contenente batteri probiotici per uso pediatrico
ATE546149T1 (de) 2009-05-11 2012-03-15 Nestec Sa Prävention und behandlung von allergischer diarrhöe
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
EP2289527B1 (de) 2009-08-25 2018-02-21 Nestec S.A. Bifidobacterium longum und funktionelle GI-Erkrankungen
IT1398648B1 (it) * 2010-03-09 2013-03-08 Probiotical Spa Prodotto alimentare comprendente batteri probiotici rivestiti con un rivestimento di origine vegetale.
EP3311825A1 (de) 2010-08-04 2018-04-25 Thomas Julius Borody Zusammensetzungen zur darmfloratransplantation und verfahren zur herstellung davon und verwendung davon
IT1403661B1 (it) 2011-01-28 2013-10-31 Probiotical Spa Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali.
WO2012122478A1 (en) 2011-03-09 2012-09-13 Regents Of The University Of Minnesota Compositions and methods for transplantation of colon microbiota
ES2561253T3 (es) * 2011-03-17 2016-02-25 Probiotical S.P.A. Bacterias probióticas que tienen actividad antioxidante y uso de las mismas
ITMI20110793A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati.
ITMI20110791A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri in grado di metabolizzare gli ossalati.
ITMI20110792A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia.
ITRM20110477A1 (it) 2011-09-09 2013-03-10 Giovanni Mogna Composizione comprendente n-acetilcisteina e/o lisozima microincapsulato gastroprotetto in associazione con batteri probiotici in grado di ripristinare l'effetto barriera proprio dello stomaco che viene perso durante il trattamento farmacologico dell
ITMI20111718A1 (it) 2011-09-23 2013-03-24 Probiotical Spa Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali.
WO2013176774A1 (en) 2012-05-25 2013-11-28 Arizona Board Of Regents Microbiome markers and therapies for autism spectrum disorders
CN103622917B (zh) * 2012-08-23 2017-12-29 尼奥克斯(文莱)控股有限公司 基于微囊化亚硝酸盐和酸化水凝胶的延时产生一氧化氮的系统和方法
ITMI20130793A1 (it) 2013-05-14 2014-11-15 Probiotical Spa Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti.
KR102561989B1 (ko) 2015-05-14 2023-07-31 핀치 테라퓨틱스 홀딩스 엘엘씨 대변 균무리 이식용 조성물, 및 이의 제조 및 사용 방법, 및 이의 전달을 위한 장치
HUE058209T2 (hu) 2015-05-22 2022-07-28 Univ Arizona State Módszerek az autizmus spektrum zavar és azzal összefüggõ tünetek kezelésére
US20170360848A1 (en) 2016-06-15 2017-12-21 Arizona Board Of Regents On Behalf Of Arizona State University Methods for treating autism spectrum disorder and associated symptoms
US10849936B2 (en) 2016-07-01 2020-12-01 Regents Of The University Of Minnesota Compositions and methods for C. difficile treatment
US20180036352A1 (en) 2016-08-03 2018-02-08 Crestovo Holdings Llc Methods for treating ulcerative colitis
US11026978B2 (en) 2016-10-11 2021-06-08 Finch Therapeutics Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
WO2018071536A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating primary sclerosing cholangitis and related disorders
US10092601B2 (en) 2016-10-11 2018-10-09 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
CA3058818A1 (en) 2017-04-05 2018-10-11 Crestovo Holdings Llc Compositions and methods for treating parkinson's disease (pd) and related disorders
US11040073B2 (en) 2017-04-05 2021-06-22 Finch Therapeutics Holdings Llc Compositions and methods for treating diverticulitis and related disorders
EP3630190B1 (de) 2017-05-26 2024-02-21 Finch Therapeutics Holdings LLC Lyophilisierte zusammensetzungen, die therapeutische mittel auf der basis von fäkalienmikroben enthalten, und verfahren zu ihrer herstellung und verwendung
AU2018313766A1 (en) 2017-08-07 2020-02-20 Finch Therapeutics, Inc. Compositions and methods for maintaining and restoring a healthy gut barrier
US11166990B2 (en) 2018-07-13 2021-11-09 Finch Therapeutics Holdings Llc Methods and compositions for treating ulcerative colitis
WO2020069280A1 (en) 2018-09-27 2020-04-02 Crestovo Holdings Llc Compositions and methods for treating epilepsy and related disorders
US20210330719A1 (en) 2018-10-02 2021-10-28 Société des Produits Nestlé S.A. Probiotic combination for treatment of inflammatory-related gastrointestinal disorders
CA3122937A1 (en) 2018-12-21 2020-06-25 Societe Des Produits Nestle S.A. Probiotic combination for treatment of allergic disorders

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US952418A (en) * 1909-08-14 1910-03-15 Emil Collett Dietetic chocolate and cocoa.
US1758937A (en) * 1925-12-05 1930-05-20 George H Earp-Thomas Lactobacteria product
US1851165A (en) * 1927-05-16 1932-03-29 Stewart M Farr Lactobacillus acidophilus milk product and its method of manufacture
US1929085A (en) * 1932-12-01 1933-10-03 Erwin A A Suehs Method of preserving viable bacilli
US2369218A (en) * 1941-01-02 1945-02-13 George F Dick Preparations of scarlet fever toxin for administration by mouth
US2376333A (en) * 1941-02-03 1945-05-22 Univ California Method of preserving microorganisms
FR1128072A (fr) * 1955-06-22 1957-01-02 Biotic Procédé pour la préparation de cultures microbiennes destinées à être conservées
US2875130A (en) * 1956-11-20 1959-02-24 Smith Kline French Lab Method of preparing sustained release particles and the product of the method
GB825480A (en) * 1957-07-13 1959-12-16 Johann Carl Pflueger Improvements in or relating to ingestible dry micro-organism preparations and method for producing the same
US3265629A (en) * 1958-12-22 1966-08-09 Ncr Co Coating by phase separation
FR1290858A (fr) * 1961-02-08 1962-04-20 Franscoma Appareil destiné à la pulvérisation de produits ou de mélanges de produits solides
BE640616A (de) * 1962-12-19
FR2828M (fr) * 1963-03-01 1964-11-02 Lucien Nouvel Médicament renfermant des colibacilles antibiorésistants.
FR3626M (fr) * 1963-11-13 1965-10-18 Lucien Nouvel Médicament pour affections intestinales.
FR1398107A (fr) * 1964-03-26 1965-05-07 Produit auxiliaire pour la fabrication des pâtes
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
FR1514115A (fr) * 1966-08-19 1968-02-23 Procédé de conservation des bactéries et produits en résultant
FR1495040A (fr) * 1966-08-24 1967-12-18 Interfett Spezialfettprodukte Procédé et dispositifs pour transformer des graisses et des mélanges d'huiles et de graisses en une poudre fine à structure cristalline
FR1584757A (de) * 1967-06-01 1970-01-02
GB1271674A (en) 1968-07-09 1972-04-26 Nisshin Flour Milling Co Process and preparation for treating diarrhoea in pigs
FR1602543A (en) * 1968-10-28 1970-12-21 Therapeutic compns contng freeze dried bacteria
US3541204A (en) * 1968-12-02 1970-11-17 Ian Ramsay Sibbald Encapsulated biologically active materials for feeding to ruminants and process for the production thereof
US3856699A (en) * 1969-08-08 1974-12-24 Fuji Photo Film Co Ltd Process for producing capsules having walls of a waxy material
US3892880A (en) * 1969-08-19 1975-07-01 Erhard Grolitsch Method for the manufacture of crystalline, flowable, stable fat powders or mixtures of such fat powders with other powdery materials
JPS4910912B1 (de) * 1970-03-17 1974-03-13
JPS4945224B1 (de) * 1970-12-14 1974-12-03
US3959493A (en) * 1971-03-17 1976-05-25 Rumen Chemie, Ag Rumen bypass products comprising biologically active substances protected with aliphatic fatty acids
BE788554A (fr) * 1971-09-23 1973-01-02 Rech Applic Scient Sogeras S A Procede pour la fabrication de substances actives pulverisees protegeescontre un milieu biologique
US3823228A (en) * 1971-09-29 1974-07-09 Univ Illinois Tge virus vaccine
DE2209565A1 (de) * 1972-02-29 1973-09-13 Lothringer Muehlen Gmbh Verfahren und vorrichtung zur herstellung eines fettkonzentrates
FR2201837A1 (en) * 1972-07-31 1974-05-03 Petroles Cie Francaise Powdered milk substitutes - contg powdered protein-rich fermented micro-organism prod esp for animal feed
DE2253515C3 (de) * 1972-10-28 1978-07-06 Fa. E. Kampffmeyer, 2000 Hamburg Verfahren zur Überführung von geschmolzenen Substanzen, insbesondere von Fetten und Fettgemischen in pulverförmige Konzentrate durch Versprühen
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US3957974A (en) * 1974-11-05 1976-05-18 Seikenkai Method for deodorization of excrements
JPS5231981A (en) * 1975-08-18 1977-03-10 Takeda Chem Ind Ltd Microcapsule preparation method
US3973053A (en) * 1975-09-24 1976-08-03 Scm Corporation Process for tempering beaded fat quickly
SU598629A1 (ru) 1976-08-16 1978-03-25 Московский Ордена Ленина И Ордена Трудового Красного Знамени Государственный Университет Им. М.В.Ломоносова Способ получени микрокапсул
DE2645444A1 (de) 1976-10-08 1978-04-13 Karl Dr Med Theurer Verfahren zur gewinnung von oral wirksamen arzneimitteln und impfstoffen aus primaer nicht darmwirksamen praeparaten
US4147773A (en) * 1977-12-12 1979-04-03 Morinaga Milk Industry Co., Ltd. Powdery composition comprising viable Bifidobacteria cells and lactulose
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004004030A1 (de) * 2004-01-27 2005-08-18 Mars Inc. Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung
DE102012008271A1 (de) 2012-04-23 2013-10-24 Human Nutrition Gmbh Kleingebäck zur Unterstützung der Gewichtsreduktion

Also Published As

Publication number Publication date
SE7909492L (sv) 1980-06-06
FR2443247B1 (de) 1983-04-29
FR2443247A1 (fr) 1980-07-04
IT7950976A0 (it) 1979-12-03
CH637297A5 (fr) 1983-07-29
AU5329879A (en) 1980-07-10
DE2946723A1 (de) 1980-06-19
ES486575A1 (es) 1980-10-01
FR2443279A1 (fr) 1980-07-04
AU526326B2 (en) 1983-01-06
MX6497E (es) 1985-06-21
US4332790A (en) 1982-06-01
SE447540B (sv) 1986-11-24
IT1164075B (it) 1987-04-08
FR2443279B1 (de) 1984-04-06
BE880027A (fr) 1980-05-14

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Legal Events

Date Code Title Description
OB Request for examination as to novelty
OC Search report available
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: A61K 9/50

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee