DE3127639A1 - Cream for the treatment of skin disorders - Google Patents

Cream for the treatment of skin disorders

Info

Publication number
DE3127639A1
DE3127639A1 DE19813127639 DE3127639A DE3127639A1 DE 3127639 A1 DE3127639 A1 DE 3127639A1 DE 19813127639 DE19813127639 DE 19813127639 DE 3127639 A DE3127639 A DE 3127639A DE 3127639 A1 DE3127639 A1 DE 3127639A1
Authority
DE
Germany
Prior art keywords
cream
zinc oxide
bismuth
treatment
red mercury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19813127639
Other languages
German (de)
Inventor
Pavel 6000 Frankfurt Kozak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kozak Pavel 6050 Offenbach De
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19813127639 priority Critical patent/DE3127639A1/en
Publication of DE3127639A1 publication Critical patent/DE3127639A1/en
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23Sulfur; Selenium; Tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27Zinc; Compounds thereof

Abstract

The invention relates to a cream for the treatment of skin disorders which contains as active ingredient a combination of red mercury sulphide, zinc oxide and bismuth nitrate in which the individual components are present in the following ratios by weight 0.1-3 g of red mercury sulphide, 0.1-15 g of zinc oxide and 0.5-15 g of bismuth subnitrate or bismuth nitrate in a conventional cream base. The cream of the invention is prepared by initially processing the zinc oxide and the bismuth subnitrate or the bismuth nitrate with part of the vehicle to give a homogeneous mixture which is then mixed with the red mercury sulphide which has been incorporated into the remaining part of the vehicle to form a homogeneous mixture. The cream of the invention is particularly suitable for the treatment of all types of infectious dermatitis superinfected with various types of Staphylococci, mycotic dermatitis, acne papulosa, acne pustulosa and acne vulgaris.

Description

Creme fUr die Behandlung von Hautkrankheiten0Cream for the treatment of skin diseases0

Die Erfindung betrifft eine Creme fUr die Behandlung von Hautkrankheiten, insbesondere fUr die Behandlung von allen Formen von infektiösen Ekzemen, superinfiziert mit verschiedenen Typen von Staphyloccccen, mykotischem Exzem, Acne palpulosa-~Acne pustnlosa und Acne vulgaris.The invention relates to a cream for the treatment of skin diseases, especially for the treatment of all forms of infectious eczema, superinfected with different types of staphylococcus, mycotic eczema, acne palpulosa- ~ acne pustnlosa and acne vulgaris.

Die vorbekannte Behandlung dieser Hautkrankheiten bestand gewöhnlich darin, intern Antibiotica zu geben und extern die erkrankte Hautoberfläche mit Zinkoxyd, Talcum und Antibiotica enthaltenden Cremes zu behandeln. Der Erfolg dieser Behandlungsweise war gering. Die Behandlung selbst brachte nur teilweise eine Linderung der Beschwerden. Außerdem war die Behandlungsdauer beschränkt, da eine Antibiotica-Behandlung Aber eine längere Dauer bekanntlich zur Resistenz gegenüber den angewandten Antibiotica fUhrt, was mit einem sehr starken Absinken der therapeutischen Wirksamkeit verbunden ist. Außerdem kann sich eine verlängerte Antibiotica-Behandlung ungünstig auf die inneren Organe des Patienten auswirken.The prior art treatment for these skin diseases usually existed in giving antibiotics internally and externally applying zinc oxide to the diseased skin surface, Treat creams containing talc and antibiotics. The success of this treatment was low. The treatment itself only partially alleviated the symptoms. In addition, the duration of treatment was limited because antibiotic treatment but a longer duration is known to result in resistance to the antibiotics used leads, which is associated with a very strong decrease in therapeutic effectiveness is. In addition, prolonged antibiotic treatment can adversely affect the patient affect the patient's internal organs.

Die Erfindung betrifft eine Creme, die sich insbesondere zur Behandlung der weiter oben genannten Hautkrankheiten eignet, die die Anwendung von Antibiotica UberflUssig,macht, infolgedessen die mit der Antibiotica-Anwendung verbundenen Nebenwirkungen nicht aufweist und mit der bereits nach kurzer Behandlungsdauer eine lang anhaltende Besserung bzw. eine Heilung erzielt wird.The invention relates to a cream that is particularly useful for treatment of the skin diseases mentioned above that makes the use of antibiotics suitable As a result, the side effects associated with the use of antibiotics are superfluous does not have and with which a long-lasting one after a short period of treatment Improvement or a cure is achieved.

Die Creme der Erfindung ist dadurch gekennzeichnet, daß sie als aktiven Wirkstoff eine aus rotem Quecksilbersulfid, Zinkoxyd und Wismutsubnitrat oder'Wismutnitrat bestehende Eombination, in der die Einzelkomponenten im Gewichtsverhältnis von 0,1 - 3 g, vorzugsweise 0t25 - 0,5 g rotes Quecksilbersulfid, 0,1 - 15 g, vorzugsweises'5 - 10 g Zinkoxyd und 0,5 - 15 g, vorzugsweise 5 - 10 g Wismutsubnitrat oder Wistnutnitrat untereinander vorliegen, in einer üblichen Cremegrundlage enthält.The cream of the invention is characterized in that it is active Active ingredient one made from red mercury sulfide, zinc oxide and bismuth subnitrate or bismuth nitrate existing combination in which the individual components in a weight ratio of 0.1 - 3 g, preferably 0t25 - 0.5 g red mercury sulfide, 0.1-15 g, preferably'5 - 10 g of zinc oxide and 0.5 - 15 g, preferably 5 - 10 g of bismuth subnitrate or Wistnut nitrate among themselves present, contains in a conventional cream base.

Als besonders zweckmäßig hat sich eine Wirkstoffkombination erwiesen, in der die Einzelkomponenten im Gewichtsvexhiltni8 von 0,4 g rotes Quecksilbersulfid, 7,5 g Zinkoxyd und-7,5 g Wismutsubnitrat oder Wismutnitrat untereinander vorliegen.A combination of active ingredients has proven to be particularly useful, in which the individual components in the weight ratio of 0.4 g red mercury sulfide, 7.5 g of zinc oxide and 7.5 g of bismuth subnitrate or bismuth nitrate are present among one another.

Die Creme der Erfindung zeichnet sich dadurch aus, daß sie gut verträglich ist und keine Nebenwirkungen zeigt, den Metabolismus der wpidermiazellen normalisiert und die Hautstruktur regeneriert, die normale Reaktionsfähigkeit der Haut gegenüber den Ublichen Belastungen, wie Sonnenbestrahlung, Temperaturschwankungen, Berührung mit Seifen, Waschmitteln, Alkohol, wiederhorstellt und daß ihre therapeutische Wirkung auch bei Anwendung Uber einen längeren Zeitraum nicht absinkt.The cream of the invention is distinguished by the fact that it is well tolerated and shows no side effects, normalizes the metabolism of the epidermal cells and the skin structure regenerates, the normal responsiveness of the skin to it the usual stresses, such as exposure to the sun, temperature fluctuations, contact with soaps, detergents, alcohol, and that their therapeutic effects does not decrease even when used over a long period of time.

Die Erfindung betrifft auch ein Verfahren zur Herstellung einer Creme fUr die Behandlung von Hautkrankheiten, wonach zunächst das Zinkoxyd und das Wismutsubnitrat oder das Wismutnitrat mit einem Teil des Trägermaterials für die Creme zu einer homogenen Mischung verarbeitet und danach mit dem in dem restlichen Teil des Trägermaterials unter Bildung einer honogenen Mischung eingearbeiteten roten Quecksilbersulfid in eine homogene Mischung Ebergeführt wird.The invention also relates to a method for producing a cream for the treatment of skin diseases, according to which zinc oxide and bismuth subnitrate first or the bismuth nitrate with part of the carrier material for the cream to one processed homogeneous mixture and then with that in the remaining part of the carrier material red mercury sulfide incorporated into the formation of a homogeneous mixture a homogeneous mixture of boars is carried.

Als Urägermaterialien können alle ftir Cremes geeigneten Cremegrundlagen auf der Basis von Glycerin, Paraffin, Lanolin, Vaselinse, Eucerin etc. verwendet werden.All cream bases suitable for creams can be used as primary carrier materials on the basis of glycerine, paraffin, lanolin, petroleum jelly, eucerin etc. used will.

Beispiel Zur Herstellung einer Creme aus o,4 g rotem.Quecksilbersulfid, 7,5 g Zinkoxyd und 7,5 g Wismutsubnitrat als Wirkstoffkombination und 6,0 g Wollwachsalkohol 10,0 g gelbe Vaseline, 25,0 g Hartparaffin und 60,0 g dickflüssigem Paraffin als Cremegrundlage werden zunächst das Zinkoxyd und das Wismutsubnitrat zu einem homogenen Pulver verrieben, in einem Teil des lickfltlssigen Paraffins geldat und danach mit den restlichen Bestandteilen der Cremegrundlage in eine homogene Mischung übergeführt. (Produkt A) In dem restlichen Teil des dickflüssigen Paraffins wird das rote Quecksilbersulfid in Idaun6 gebracht. (Produkt B) Danach wird Produkt A in kleinen Anteilen dem Produkt B unter Homogenisieren einverleibt.Example For the production of a cream from 0.4 g of red mercury sulfide, 7.5 g zinc oxide and 7.5 g bismuth subnitrate as a combination of active ingredients and 6.0 g wool wax alcohol 10.0 g yellow vaseline, 25.0 g hard paraffin and 60.0 g thick Paraffin as a cream base is initially zinc oxide and bismuth subnitrate rubbed into a homogeneous powder, in part of the liquid paraffin geldat and then with the remaining components of the cream base into a homogeneous Mixture transferred. (Product A) In the remaining part of the thick paraffin the red mercury sulphide is brought to Idaun6. (Product B) Then becomes product A incorporated in small portions into product B with homogenization.

Die Behandlung erfolgt zweckmäßig in der Weise, daß die Creme auf die erkrankten Hautpartien in ausreichender Menge aufgetragen und mit saugfähigen Kompressen, vorzugsweise aus Baumwolle, die alle 3 Stunden zu erneuern sind, abgedeckt werden.The treatment is expediently carried out in such a way that the cream on the diseased areas of skin applied in sufficient quantities and with absorbent Compresses, preferably made of cotton, to be replaced every 3 hours, covered will.

Die statistische Auswertung von klinischen Versuchen, bei denen die Creme des Beispiels der Erfindung mit einer Neomycinsulfat, Zinkoxyd und Talcum enthaltenden Salbe bei Anwendung bei superinfizierter Dermatose in ihrer Wirkung verglichen worden sind, ergab die in der nachfolgenden Tabelle zusammengestellten Werte0: Creme der Antibioticum, Zinkoxyd Erfindung und album enthaltende Creme Heilung der entzilndeten Hautpartien 98 * 10,' Regenerierung der Hautoberfläche 98 * 10 % Verträglichkeit 100 * 85 % Rezidive 15 * 70 %The statistical evaluation of clinical trials in which the Cream of the example of the invention with a neomycin sulfate, zinc oxide and talc containing ointment when used in superinfected dermatosis in their effect have been compared, resulted in those compiled in the table below Values0: cream of antibiotic, zinc oxide invention and album containing cream healing of the inflamed skin areas 98 * 10, 'Regeneration of the skin surface 98 * 10 % Tolerance 100 * 85% recurrences 15 * 70%

Claims (4)

Patentansprüche 1) Creme für die Behandlung von Hautkrankheiten, dadurch gekennzeichnet, daß sie als aktiven. Wirkstoff eine aus rotem Quecksilbersulfid, Zinkoxyd und Wismutnitrat bestehende Kombination, in der die Einzelkomponenten im Gewichtsverhältnis von 0,1 bis 3 g rotes Quecksilbersulfid, 0,1 bis 15 g Zinkoxyd und 0,5 bis 15 g Wismutsubnitrat oder Wismutnitrat untereinander vorliegen, in einer Ublichen Cremegrundlage enthält.Claims 1) Cream for the treatment of skin diseases, thereby marked them as active. Active ingredient one made from red mercury sulphide, Zinc oxide and bismuth nitrate existing combination in which the individual components in Weight ratio of 0.1 to 3 g of red mercury sulfide, 0.1 to 15 g of zinc oxide and 0.5 to 15 g of bismuth subnitrate or bismuth nitrate are present in one Contains usual cream base. 2) Creme nach Anspruch 1, dadurch gekennzeichnet, daß sie als aktiven Wirkstoff eine Kombination enthaltç in der die Einzelkomponenten im Gewichtsverhältnis von 0,?5 bis 0,5 g rotes Quecksilbersulfid, 5 bis 10 g Zinkoxyd und 5 bis 10 g Wismutsubnitrat oder Wismutnitrat untereinander vorliegen.2) cream according to claim 1, characterized in that it is considered active Active ingredient contains a combination in which the individual components in weight ratio from 0.5 to 0.5 g of red mercury sulfide, 5 to 10 g of zinc oxide and 5 to 10 g of bismuth subnitrate or bismuth nitrate are present among one another. 3) Creme nach Anspruch 1, dadurch gekennzeichnet, daß sie als aktiven Wirkstoff eine Kombination enthalt, in der die Einzelkomponenten im Gewichtsverhältnis von 0,4 g rotes Quecksilbersulfid, 7,5 g Zinkoxyd und 7,5 g Wismutsubnitrat oder Wismutnitrat untereinander vorlieen.3) cream according to claim 1, characterized in that it is considered active Active ingredient contains a combination in which the individual components in weight ratio of 0.4 g of red mercury sulfide, 7.5 g of zinc oxide and 7.5 g of bismuth subnitrate or Bismuth nitrate are present among each other. 4) Verfahren zur Herstellung einer Creme gemäß Anspruch 1 bis 3, dadurch gekennzeichnet, daß man zunächst das Zinkoxyd und das Wismutsubnitrat oder das Wismutnitrat mit einem Teil des Grägermaterials zu einer homogenen Mischung verarbeitet, die danach mit dem in dem restlichen Teil des Trägermaterials unter Bildung $ ner homogenen Mischung eingearbeiteten roten Quecksilbersulfid vermischt wird.4) A method for producing a cream according to claim 1 to 3, characterized characterized in that the zinc oxide and bismuth subnitrate or bismuth nitrate are first used processed with part of the backing material to a homogeneous mixture, which then with that in the remaining part of the carrier material to form a homogeneous one Mixture incorporated red mercury sulfide is mixed.
DE19813127639 1980-07-12 1981-07-13 Cream for the treatment of skin disorders Ceased DE3127639A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19813127639 DE3127639A1 (en) 1980-07-12 1981-07-13 Cream for the treatment of skin disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3026505 1980-07-12
DE19813127639 DE3127639A1 (en) 1980-07-12 1981-07-13 Cream for the treatment of skin disorders

Publications (1)

Publication Number Publication Date
DE3127639A1 true DE3127639A1 (en) 1982-08-19

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DE19813127639 Ceased DE3127639A1 (en) 1980-07-12 1981-07-13 Cream for the treatment of skin disorders

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DE (1) DE3127639A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007509A1 (en) * 1992-09-25 1994-04-14 Lange Claus E Topical treatment agent or medicament containing finely divided transparent zinc oxide
DE4329379C1 (en) * 1993-09-01 1995-02-16 Beiersdorf Ag Against blemished skin and mild forms of acne effective preparations containing wool wax acids
EP0879035A1 (en) * 1995-08-24 1998-11-25 Josman Laboratories, Inc. Bismuth-containing compounds in topical dosage forms
US6426085B1 (en) 1994-05-02 2002-07-30 Josman Laboratories Inc. Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis
US6616938B2 (en) 1994-05-02 2003-09-09 Josman Laboratories, Inc. Method of making chewing gum containing colloidal bismuth subcitrate
US6902738B2 (en) 1994-05-02 2005-06-07 Josman Laboratories, Inc. Topical oral dosage forms containing bismuth compounds
ES2292346A1 (en) * 2006-05-23 2008-03-01 Monica Martinez Beltran Method for producing balsam cream used cosmetically against skin irritations, involves heating oily vaseline and anhydrous lanolin to sixty five degree celsius, where homogenization of vaseline and lanolin is carried out followed by cooling

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hager: Handbuch der pharmazeutischen Praxis, 4. Ausg., Bd. 3, 1972, S. 470-471, Bd. 5, 1976, S. 141-142 u. Bd. 6, Teil C, 1979, S. 561-562 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007509A1 (en) * 1992-09-25 1994-04-14 Lange Claus E Topical treatment agent or medicament containing finely divided transparent zinc oxide
DE4329379C1 (en) * 1993-09-01 1995-02-16 Beiersdorf Ag Against blemished skin and mild forms of acne effective preparations containing wool wax acids
US6426085B1 (en) 1994-05-02 2002-07-30 Josman Laboratories Inc. Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis
US6616938B2 (en) 1994-05-02 2003-09-09 Josman Laboratories, Inc. Method of making chewing gum containing colloidal bismuth subcitrate
US6902738B2 (en) 1994-05-02 2005-06-07 Josman Laboratories, Inc. Topical oral dosage forms containing bismuth compounds
EP0879035A1 (en) * 1995-08-24 1998-11-25 Josman Laboratories, Inc. Bismuth-containing compounds in topical dosage forms
EP0879035A4 (en) * 1995-08-24 2001-10-31 Josman Lab Inc Bismuth-containing compounds in topical dosage forms
ES2292346A1 (en) * 2006-05-23 2008-03-01 Monica Martinez Beltran Method for producing balsam cream used cosmetically against skin irritations, involves heating oily vaseline and anhydrous lanolin to sixty five degree celsius, where homogenization of vaseline and lanolin is carried out followed by cooling

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: KOZAK, PAVEL, 6050 OFFENBACH, DE

8131 Rejection