DE3278165D1 - Nucleotide-based substrates - Google Patents

Nucleotide-based substrates

Info

Publication number
DE3278165D1
DE3278165D1 DE8282102643T DE3278165T DE3278165D1 DE 3278165 D1 DE3278165 D1 DE 3278165D1 DE 8282102643 T DE8282102643 T DE 8282102643T DE 3278165 T DE3278165 T DE 3278165T DE 3278165 D1 DE3278165 D1 DE 3278165D1
Authority
DE
Germany
Prior art keywords
nitrophenyl
substrates
group
umbelliferonyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282102643T
Other languages
English (en)
Inventor
James R Gohlke
Eddie Hedaya
Jemo Kang
Jeanette D Mier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Corp
Original Assignee
Biochem Immunosystems US Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochem Immunosystems US Inc filed Critical Biochem Immunosystems US Inc
Application granted granted Critical
Publication of DE3278165D1 publication Critical patent/DE3278165D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
DE8282102643T 1981-03-30 1982-03-29 Nucleotide-based substrates Expired DE3278165D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/248,672 US4378458A (en) 1981-03-30 1981-03-30 Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity

Publications (1)

Publication Number Publication Date
DE3278165D1 true DE3278165D1 (en) 1988-04-07

Family

ID=22940161

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282102643T Expired DE3278165D1 (en) 1981-03-30 1982-03-29 Nucleotide-based substrates

Country Status (7)

Country Link
US (1) US4378458A (de)
EP (1) EP0061762B1 (de)
JP (1) JPS57177697A (de)
AT (1) ATE32726T1 (de)
CA (1) CA1194861A (de)
DE (1) DE3278165D1 (de)
IE (1) IE53887B1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529796A (en) * 1981-03-30 1985-07-16 Baker Instruments Corporation Method for making chromogenic and/or fluorogenic substrates for use in monitoring catalytic or enzymatic activity
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides
US4482708A (en) * 1982-08-09 1984-11-13 Nguyen Nicolas C 3', 5'-Dinucleoside phosphates of 5,6-dichloro-1-β-D-ribofuranosyl-1-benzimidazole and methods of making and using the same
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
EP0406309A4 (en) * 1988-03-25 1992-08-19 The University Of Virginia Alumni Patents Foundation Oligonucleotide n-alkylphosphoramidates
US5362627A (en) * 1988-09-12 1994-11-08 E. I. Du Pont De Nemours And Company Stabilization and reduction of background fluorescence of hydroxy coumarin ester enzyme substrates
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
ES2169071T3 (es) * 1993-04-13 2002-07-01 Naxcor Derivados de cumarina no nucleosidicos como agentes de entrecruzamiento de polinucleotidos.
US6495676B1 (en) * 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905871A (en) * 1971-05-14 1975-09-16 Syva Co Lactam conjugates to enzymes
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
US4067774A (en) * 1971-05-14 1978-01-10 Syva Company Compounds for enzyme amplification assay
US4046636A (en) * 1974-06-20 1977-09-06 Syva Company Diazepam enzyme conjugates
US4191613A (en) * 1971-05-14 1980-03-04 Syva Company Malate dehydrogenase conjugates for enzyme immunoassays
PL81969B1 (de) 1971-06-30 1975-10-31
US4039385A (en) * 1972-05-08 1977-08-02 Syva Company Cardiac glycoside enzyme conjugates
US3875011A (en) * 1972-11-06 1975-04-01 Syva Co Enzyme immunoassays with glucose-6-phosphate dehydrogenase
US3966556A (en) * 1972-11-06 1976-06-29 Syva Company Compounds for enzyme amplification assay methadone analogs
US4161515A (en) * 1973-10-02 1979-07-17 Syva Company Double receptor fluorescent immunoassay
US3998943A (en) * 1973-10-02 1976-12-21 Syva Company Double receptor fluorescent immunoassay
US4040907A (en) * 1974-06-20 1977-08-09 Syva Company Iodothyronine enzyme conjugates
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4065354A (en) * 1974-10-10 1977-12-27 Syva Company Lysozyme conjugates for enzyme immunoassays
US4043872A (en) * 1975-02-20 1977-08-23 Syva Company Polyiodothyronine immunoassay
US4171244A (en) * 1975-02-20 1979-10-16 Syva Company Enzyme-bound-polyidothyronine
IN142734B (de) * 1975-04-28 1977-08-20 Miles Lab
US4174384A (en) * 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
IT1079045B (it) * 1977-05-16 1985-05-08 Syva Co Analisi imuunologica fluorescente a doppio ricettore
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays

Also Published As

Publication number Publication date
US4378458A (en) 1983-03-29
JPS57177697A (en) 1982-11-01
IE53887B1 (en) 1989-04-12
ATE32726T1 (de) 1988-03-15
CA1194861A (en) 1985-10-08
EP0061762A2 (de) 1982-10-06
EP0061762B1 (de) 1988-03-02
EP0061762A3 (en) 1983-03-16
JPH0138479B2 (de) 1989-08-14
IE820575L (en) 1982-09-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8327 Change in the person/name/address of the patent owner

Owner name: BIOPHARMA S.A., LUXEMBURG/LUXEMBOURG, LU

8328 Change in the person/name/address of the agent

Free format text: DAUM, M., DR.-ING., PAT.-ASS., 6800 MANNHEIM

8327 Change in the person/name/address of the patent owner

Owner name: GALENO B.V., AMSTERDAM, NL

8327 Change in the person/name/address of the patent owner

Owner name: PHARMINVEST S.A., LUXEMBOURG, LU

8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER MANNHEIM CORP., INDIANAPOLIS, IND., US

8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS CORP., INDIANAPOLIS, IND., US