DE3377127D1 - Process for the preparation of astaxanthine and intermediates in the astaxanthine synthesis - Google Patents

Process for the preparation of astaxanthine and intermediates in the astaxanthine synthesis

Info

Publication number
DE3377127D1
DE3377127D1 DE8383107909T DE3377127T DE3377127D1 DE 3377127 D1 DE3377127 D1 DE 3377127D1 DE 8383107909 T DE8383107909 T DE 8383107909T DE 3377127 T DE3377127 T DE 3377127T DE 3377127 D1 DE3377127 D1 DE 3377127D1
Authority
DE
Germany
Prior art keywords
astaxanthine
intermediates
synthesis
preparation
astaxanthine synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383107909T
Other languages
English (en)
Inventor
Kurt Dr Bernhard
Robert Karl Dr Muller
Robert Dr Spruijtenburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE3377127D1 publication Critical patent/DE3377127D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5435—Cycloaliphatic phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
DE8383107909T 1982-08-20 1983-08-10 Process for the preparation of astaxanthine and intermediates in the astaxanthine synthesis Expired DE3377127D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH498382 1982-08-20
CH339283 1983-06-21

Publications (1)

Publication Number Publication Date
DE3377127D1 true DE3377127D1 (en) 1988-07-28

Family

ID=25692900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383107909T Expired DE3377127D1 (en) 1982-08-20 1983-08-10 Process for the preparation of astaxanthine and intermediates in the astaxanthine synthesis

Country Status (5)

Country Link
US (1) US4585885A (de)
EP (1) EP0101597B1 (de)
JP (1) JPH0717661B2 (de)
DE (1) DE3377127D1 (de)
DK (1) DK381383A (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642362A (en) * 1984-01-30 1987-02-10 Loctite (Ireland) Limited Polymer bound calixarenes
US5225604A (en) * 1989-11-27 1993-07-06 Neurosearch A/S Hydroxycarbonyl derivatives and process for making the same
DK595489D0 (da) * 1989-11-27 1989-11-27 Neurosearch As Hydroxycarbonylderivater og fremgangsmaade til fremstilling af samme
IE69959B1 (en) * 1990-02-01 1996-10-16 Neurosearch As Hydroxycarbonyl derivatives and process for making the same
DE4014203A1 (de) * 1990-05-03 1991-11-07 Basf Ag Verfahren zur herstellung von canthaxanthin und astaxanthin
US5107010A (en) * 1990-12-12 1992-04-21 Neurosearch A/S Astaxanthin intermediates
US5175332A (en) * 1991-12-16 1992-12-29 Dow Corning Corporation Cycloalkoxysilanes
DE4322277A1 (de) * 1993-07-05 1995-01-12 Basf Ag Verbessertes Verfahren zur Herstellung von Astaxanthin, neue Zwischenprodukte hierfür sowie ein Verfahren zu deren Herstellung
CA2191351A1 (en) * 1994-05-31 1995-12-07 Alois Jungbauer Sterilization of liquid chromatography resins
DE19509955A1 (de) * 1995-03-18 1996-09-19 Basf Ag Verfahren zur Herstellung von Astaxanthin
EP1253131A1 (de) * 2001-04-24 2002-10-30 Aventis Animal Nutrition S.A. Verfahren zur Herstellung eines Xanthophylls
BRPI0313155B8 (pt) * 2002-07-29 2021-05-25 Cardax Pharmaceuticals Inc composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto
US7320997B2 (en) * 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US20060178538A1 (en) * 2004-10-01 2006-08-10 Lockwood Samuel F Methods for the synthesis of chiral dihydroxy intermediates useful for the chiral synthesis of carotenoids
US20080216756A1 (en) 2004-10-08 2008-09-11 Coho Hydroclean S.A. Method Of Cultivating Animals To Develop A Desired Color And To Increase Their Rate Of Growth
DE112007001144T5 (de) 2006-05-10 2009-04-16 Dsm Ip Assets B.V. Verfahren zur Herstellung von Astaxanthin
WO2008003737A1 (de) * 2006-07-07 2008-01-10 Basf Se Verfahren zur herstellung von 3,3'-dihydroxyisorenieratin sowie neue zwischenprodukte hierfür
MX2011005264A (es) * 2008-11-19 2011-08-03 Innova Andina S A Metodo para la preparacion de oxicarotenoides.
DK2776447T4 (da) 2011-11-09 2022-03-28 Basf Se Fremgangsmåde til fremstilling af oxovinylionol og dets o-beskyttede derivater
US9061982B2 (en) 2011-11-09 2015-06-23 Basf Se Process for the preparation of oxovinylionol and its O-protected derivatives
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH623304A5 (de) * 1975-11-30 1981-05-29 Hoffmann La Roche
EP0005749B1 (de) * 1978-06-02 1983-03-30 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cyclohexenderivate, Verfahren zu deren Herstellung, sowie deren Verwendung
US4238401A (en) * 1978-07-24 1980-12-09 General Electric Company Alkoxysilicon materials and method for making
US4210596A (en) * 1978-07-24 1980-07-01 General Electric Company Silyl ethers of 1,3-dicarbonyl cyclic compounds

Also Published As

Publication number Publication date
EP0101597A2 (de) 1984-02-29
JPH0717661B2 (ja) 1995-03-01
EP0101597A3 (en) 1985-11-27
DK381383D0 (da) 1983-08-19
EP0101597B1 (de) 1988-06-22
DK381383A (da) 1984-02-21
US4585885A (en) 1986-04-29
JPH0565290A (ja) 1993-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8339 Ceased/non-payment of the annual fee